PGK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)6.06289748
2glucose 6-phosphate metabolic process (GO:0051156)5.69753931
3positive regulation of mitochondrial fission (GO:0090141)5.43999854
4folic acid-containing compound biosynthetic process (GO:0009396)5.33444028
5IMP biosynthetic process (GO:0006188)5.14007729
6nuclear pore organization (GO:0006999)5.06031527
7protein localization to kinetochore (GO:0034501)4.86330620
8regulation of translational fidelity (GO:0006450)4.77710204
9IMP metabolic process (GO:0046040)4.75519868
10* glycolytic process (GO:0006096)4.70263869
11establishment of viral latency (GO:0019043)4.66452508
12nuclear pore complex assembly (GO:0051292)4.58590023
13mitochondrial fragmentation involved in apoptotic process (GO:0043653)4.58277972
14mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.46695250
15positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.46695250
16regulation of translational termination (GO:0006449)4.32765775
17regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.32630042
18heterochromatin organization (GO:0070828)4.28052019
19formation of translation preinitiation complex (GO:0001731)4.23135881
204-hydroxyproline metabolic process (GO:0019471)4.20949840
21protein maturation by protein folding (GO:0022417)4.17120545
22mitotic nuclear envelope disassembly (GO:0007077)4.14277080
23pentose-phosphate shunt (GO:0006098)4.13686976
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.05154411
25mitotic chromosome condensation (GO:0007076)4.02698315
26sister chromatid segregation (GO:0000819)3.93245717
27nuclear envelope disassembly (GO:0051081)3.92887877
28membrane disassembly (GO:0030397)3.92887877
29retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.91338588
30peptidyl-arginine omega-N-methylation (GO:0035247)3.90739198
31protein retention in ER lumen (GO:0006621)3.90669431
32nucleobase biosynthetic process (GO:0046112)3.90152496
33mitotic sister chromatid segregation (GO:0000070)3.84838533
34cholesterol biosynthetic process (GO:0006695)3.83128011
35protein hydroxylation (GO:0018126)3.78291779
36peptidyl-proline hydroxylation (GO:0019511)3.72388942
37NADPH regeneration (GO:0006740)3.70962811
38DNA replication initiation (GO:0006270)3.70924709
39regulation of mitochondrial fission (GO:0090140)3.64215968
40regulation of posttranscriptional gene silencing (GO:0060147)3.62688363
41regulation of gene silencing by miRNA (GO:0060964)3.62688363
42regulation of gene silencing by RNA (GO:0060966)3.62688363
43protein localization to chromosome, centromeric region (GO:0071459)3.59701574
44tricarboxylic acid cycle (GO:0006099)3.57719735
45purine nucleobase biosynthetic process (GO:0009113)3.56002515
46regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.55663132
47peptidyl-lysine dimethylation (GO:0018027)3.54759803
48DNA strand elongation involved in DNA replication (GO:0006271)3.52196285
49nuclear envelope reassembly (GO:0031468)3.50926543
50mitotic nuclear envelope reassembly (GO:0007084)3.50926543
51DNA geometric change (GO:0032392)3.50828149
52regulation of cofactor metabolic process (GO:0051193)3.50756061
53regulation of coenzyme metabolic process (GO:0051196)3.50756061
54DNA duplex unwinding (GO:0032508)3.50435312
55de novo posttranslational protein folding (GO:0051084)3.48045696
56L-serine metabolic process (GO:0006563)3.45950100
57DNA replication-dependent nucleosome organization (GO:0034723)3.45485535
58DNA replication-dependent nucleosome assembly (GO:0006335)3.45485535
59de novo protein folding (GO:0006458)3.42257203
60pre-miRNA processing (GO:0031054)3.40649819
61peptidyl-arginine methylation (GO:0018216)3.40230906
62peptidyl-arginine N-methylation (GO:0035246)3.40230906
63chaperone-mediated protein complex assembly (GO:0051131)3.40212258
64* pyruvate metabolic process (GO:0006090)3.39258063
65mitochondrial fission (GO:0000266)3.34297456
66regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.32479141
67sterol biosynthetic process (GO:0016126)3.31507938
68histone arginine methylation (GO:0034969)3.28781972
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.28239578
70DNA strand elongation (GO:0022616)3.26000437
71pore complex assembly (GO:0046931)3.24828141
72fructose metabolic process (GO:0006000)3.24788216
73mitotic metaphase plate congression (GO:0007080)3.23200970
74proline biosynthetic process (GO:0006561)3.20266423
75spliceosomal tri-snRNP complex assembly (GO:0000244)3.18485540
76tRNA aminoacylation for protein translation (GO:0006418)3.15211875
77tetrahydrofolate metabolic process (GO:0046653)3.11007767
78oxaloacetate metabolic process (GO:0006107)3.10950719
79postreplication repair (GO:0006301)3.10894553
80* single-organism carbohydrate catabolic process (GO:0044724)3.10438520
81* gluconeogenesis (GO:0006094)3.08674946
82nuclear envelope organization (GO:0006998)3.07877060
83chromatin assembly (GO:0031497)3.07651250
84negative regulation of histone methylation (GO:0031061)3.06404116
85regulation of protein heterodimerization activity (GO:0043497)3.04509329
86positive regulation of SMAD protein import into nucleus (GO:0060391)3.02976592
87positive regulation of receptor biosynthetic process (GO:0010870)3.01960492
88tRNA aminoacylation (GO:0043039)3.01131811
89amino acid activation (GO:0043038)3.01131811
90regulation of spindle organization (GO:0090224)3.00901438
91regulation of histone H3-K9 methylation (GO:0051570)3.00404805
92dosage compensation (GO:0007549)2.98385382
93cullin deneddylation (GO:0010388)2.96483262
94paraxial mesoderm development (GO:0048339)2.96151750
95regulation of sister chromatid cohesion (GO:0007063)2.95124620
96regulation of mitotic spindle organization (GO:0060236)2.95046034
97mitochondrial fusion (GO:0008053)2.93734290
98DNA ligation (GO:0006266)2.92810171
99glucose catabolic process (GO:0006007)2.92274538
100ribosome assembly (GO:0042255)2.90736223
101histone-serine phosphorylation (GO:0035404)2.89508855
102actin-myosin filament sliding (GO:0033275)2.87693775
103muscle filament sliding (GO:0030049)2.87693775
104* carbohydrate catabolic process (GO:0016052)2.86731646
105deoxyribonucleotide biosynthetic process (GO:0009263)2.85407459
106aldehyde catabolic process (GO:0046185)2.84605354
107positive regulation of chromosome segregation (GO:0051984)2.84136706
108establishment of integrated proviral latency (GO:0075713)2.81710001
109carbohydrate phosphorylation (GO:0046835)2.81543105
110positive regulation of mitochondrial membrane permeability (GO:0035794)2.81495594
111vesicle coating (GO:0006901)2.81000177
112NLS-bearing protein import into nucleus (GO:0006607)2.80492178
113ribonucleoprotein complex disassembly (GO:0032988)2.80069012
114mitotic sister chromatid cohesion (GO:0007064)2.79751139
115sequestering of actin monomers (GO:0042989)2.79750518
116oxidative phosphorylation (GO:0006119)2.78349957
117negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77988875
118T cell apoptotic process (GO:0070231)2.77683270
119COPI coating of Golgi vesicle (GO:0048205)2.77476043
120Golgi transport vesicle coating (GO:0048200)2.77476043
121chromosome condensation (GO:0030261)2.76886282
122protein deneddylation (GO:0000338)2.74938327
123regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.74820373
124nucleobase-containing small molecule interconversion (GO:0015949)2.74024379
125ribosomal small subunit assembly (GO:0000028)2.73399790
126metaphase plate congression (GO:0051310)2.72227283
127regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.70883239
128regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70376303
129negative regulation of DNA repair (GO:0045738)2.69585946
130DNA damage response, detection of DNA damage (GO:0042769)2.69535861
131regulation of oxidative stress-induced neuron death (GO:1903203)2.69484884
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.68525283
133establishment of chromosome localization (GO:0051303)2.68405657
134melanin biosynthetic process (GO:0042438)2.68329220
135regulation of centrosome cycle (GO:0046605)2.68254496
136layer formation in cerebral cortex (GO:0021819)2.68065136
137galactose catabolic process (GO:0019388)2.66463070
138mRNA stabilization (GO:0048255)2.66309118
139RNA stabilization (GO:0043489)2.66309118
140maternal placenta development (GO:0001893)2.65984947
141telomere maintenance via semi-conservative replication (GO:0032201)2.65677428
142* hexose biosynthetic process (GO:0019319)2.64215884
143regulation of centriole replication (GO:0046599)2.63546141
144regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.62559847
145* monosaccharide biosynthetic process (GO:0046364)2.62452157
146negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.58915784
147negative regulation of ligase activity (GO:0051352)2.58915784
148spliceosomal snRNP assembly (GO:0000387)2.57726141
149regulation of translational elongation (GO:0006448)2.56796238
150base-excision repair (GO:0006284)2.56779816
151positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.55694444
152double-strand break repair via nonhomologous end joining (GO:0006303)2.55277735
153non-recombinational repair (GO:0000726)2.55277735
154COPII vesicle coating (GO:0048208)2.53884967
155nucleoside diphosphate biosynthetic process (GO:0009133)2.53858457

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.85752908
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.80148248
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.09063668
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.96084049
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.50033595
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.24488790
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.96109384
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.84986979
9HIF1A_21447827_ChIP-Seq_MCF-7_Human2.70477457
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.61553619
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60626403
12AR_21909140_ChIP-Seq_LNCAP_Human2.55698232
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51750831
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42460057
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.21721307
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.20509590
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20094639
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18034972
19ESR1_15608294_ChIP-ChIP_MCF-7_Human2.15677418
20* XRN2_22483619_ChIP-Seq_HELA_Human2.14617685
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03738440
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.00313923
23MYC_22102868_ChIP-Seq_BL_Human1.99971455
24E2F1_21310950_ChIP-Seq_MCF-7_Human1.98055697
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81337898
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79712072
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.78386302
28ZFX_18555785_ChIP-Seq_MESCs_Mouse1.75595287
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71755534
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69133867
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.68006183
32CLOCK_20551151_ChIP-Seq_293T_Human1.67642955
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.65080574
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64820481
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.63600336
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60888059
37DCP1A_22483619_ChIP-Seq_HELA_Human1.59603634
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59547826
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59243710
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57399476
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56762517
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56106027
43TTF2_22483619_ChIP-Seq_HELA_Human1.56015324
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.54573542
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54323787
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.50509336
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48730941
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.48405217
49TFEB_21752829_ChIP-Seq_HELA_Human1.48210169
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48146094
51ELK1_19687146_ChIP-ChIP_HELA_Human1.45165720
52* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43429960
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41251463
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.40563648
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38598832
56SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.37770930
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36059147
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35135918
59TP63_17297297_ChIP-ChIP_HaCaT_Human1.34674915
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34275322
61CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.34016330
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33798366
63KDM5A_27292631_Chip-Seq_BREAST_Human1.29454868
64GABP_19822575_ChIP-Seq_HepG2_Human1.29140332
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28708906
66CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26734809
67GABP_17652178_ChIP-ChIP_JURKAT_Human1.26273179
68ATF3_27146783_Chip-Seq_COLON_Human1.25223323
69* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24833894
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23620827
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23216178
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22159039
73SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20847109
74* VDR_23849224_ChIP-Seq_CD4+_Human1.20402568
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18865877
76FOXP3_21729870_ChIP-Seq_TREG_Human1.18355619
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17945530
78NANOG_21062744_ChIP-ChIP_HESCs_Human1.17028980
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.16106623
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15085017
81TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.14929173
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14577779
83IRF1_19129219_ChIP-ChIP_H3396_Human1.14442715
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14326575
85* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13563803
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13532728
87ZNF263_19887448_ChIP-Seq_K562_Human1.12886233
88VDR_21846776_ChIP-Seq_THP-1_Human1.12364253
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11013154
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10359085
91SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10146163
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08624029
93JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.07633335
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07298146
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.06616626
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06007462
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05828155
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05336678
99OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05198984
100SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.04743594
101CHD1_26751641_Chip-Seq_LNCaP_Human1.02768616
102E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02260960
103CIITA_25753668_ChIP-Seq_RAJI_Human1.01904495
104ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01811604
105TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.01682114
106SALL1_21062744_ChIP-ChIP_HESCs_Human1.01093432
107POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99833533
108KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98724841
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98675858
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98118003
111HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97175509
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96961626
113PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96311962
114RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96205574
115PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96037696
116SOX2_16153702_ChIP-ChIP_HESCs_Human0.95119035
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94677737
118SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94498135
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92628862
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91193796
121SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88622998
122EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87520010
123SOX17_20123909_ChIP-Seq_XEN_Mouse0.83444220

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.97279293
2MP0004084_abnormal_cardiac_muscle3.31466591
3MP0003123_paternal_imprinting3.29103211
4MP0010352_gastrointestinal_tract_polyps3.08071028
5MP0001529_abnormal_vocalization2.98565686
6MP0004957_abnormal_blastocyst_morpholog2.92131060
7MP0010094_abnormal_chromosome_stability2.76401627
8MP0010307_abnormal_tumor_latency2.64794933
9MP0003111_abnormal_nucleus_morphology2.55750044
10MP0003077_abnormal_cell_cycle2.50393911
11MP0001730_embryonic_growth_arrest2.47910194
12MP0005394_taste/olfaction_phenotype2.47731730
13MP0005499_abnormal_olfactory_system2.47731730
14MP0010234_abnormal_vibrissa_follicle2.45669141
15MP0004233_abnormal_muscle_weight2.38112694
16MP0008260_abnormal_autophagy2.28109488
17MP0003567_abnormal_fetal_cardiomyocyte2.25917375
18MP0003221_abnormal_cardiomyocyte_apopto2.25898147
19MP0002877_abnormal_melanocyte_morpholog2.09178859
20MP0010030_abnormal_orbit_morphology2.07378270
21MP0003121_genomic_imprinting2.05871803
22MP0000537_abnormal_urethra_morphology2.05246539
23MP0004197_abnormal_fetal_growth/weight/2.02758418
24MP0003693_abnormal_embryo_hatching2.02652001
25MP0003566_abnormal_cell_adhesion1.98994698
26MP0000372_irregular_coat_pigmentation1.92106611
27MP0005076_abnormal_cell_differentiation1.88657691
28MP0001697_abnormal_embryo_size1.87234233
29MP0003984_embryonic_growth_retardation1.84777266
30MP0005623_abnormal_meninges_morphology1.84674719
31MP0002088_abnormal_embryonic_growth/wei1.83672872
32MP0000350_abnormal_cell_proliferation1.81199243
33MP0001672_abnormal_embryogenesis/_devel1.80032889
34MP0005380_embryogenesis_phenotype1.80032889
35MP0008058_abnormal_DNA_repair1.79749940
36MP0009697_abnormal_copulation1.78205239
37MP0003122_maternal_imprinting1.73232466
38MP0002084_abnormal_developmental_patter1.66333403
39MP0004036_abnormal_muscle_relaxation1.65222953
40MP0003315_abnormal_perineum_morphology1.63610834
41MP0008932_abnormal_embryonic_tissue1.62205260
42MP0002080_prenatal_lethality1.59903598
43MP0002086_abnormal_extraembryonic_tissu1.59838869
44MP0006035_abnormal_mitochondrial_morpho1.57286544
45MP0000778_abnormal_nervous_system1.56493034
46MP0008775_abnormal_heart_ventricle1.56130669
47MP0003880_abnormal_central_pattern1.55207174
48MP0008007_abnormal_cellular_replicative1.54027702
49MP0004859_abnormal_synaptic_plasticity1.53700200
50MP0004087_abnormal_muscle_fiber1.53508931
51MP0000733_abnormal_muscle_development1.51742081
52MP0010630_abnormal_cardiac_muscle1.48786989
53MP0000749_muscle_degeneration1.46271422
54MP0003806_abnormal_nucleotide_metabolis1.45941479
55MP0000750_abnormal_muscle_regeneration1.43690447
56MP0009053_abnormal_anal_canal1.43066618
57MP0008789_abnormal_olfactory_epithelium1.42444866
58MP0002269_muscular_atrophy1.42076056
59MP0002085_abnormal_embryonic_tissue1.41411291
60MP0003950_abnormal_plasma_membrane1.37522989
61MP0001849_ear_inflammation1.36289673
62MP0002653_abnormal_ependyma_morphology1.35597146
63MP0005023_abnormal_wound_healing1.32689375
64MP0000747_muscle_weakness1.32079977
65MP0000751_myopathy1.31015907
66MP0003329_amyloid_beta_deposits1.30901382
67MP0008438_abnormal_cutaneous_collagen1.30148244
68MP0003186_abnormal_redox_activity1.30132498
69MP0006072_abnormal_retinal_apoptosis1.28309072
70MP0001727_abnormal_embryo_implantation1.26116012
71MP0004272_abnormal_basement_membrane1.25811301
72MP0002972_abnormal_cardiac_muscle1.22910560
73MP0003890_abnormal_embryonic-extraembry1.22259752
74MP0000647_abnormal_sebaceous_gland1.18510331
75MP0004808_abnormal_hematopoietic_stem1.17751463
76MP0005330_cardiomyopathy1.17449629
77MP0001544_abnormal_cardiovascular_syste1.15514190
78MP0005385_cardiovascular_system_phenoty1.15514190
79MP0001299_abnormal_eye_distance/1.14496389
80MP0001293_anophthalmia1.14141934
81MP0003937_abnormal_limbs/digits/tail_de1.12853751
82MP0004811_abnormal_neuron_physiology1.12303828
83MP0009672_abnormal_birth_weight1.05855624
84MP0001915_intracranial_hemorrhage1.05656061
85MP0001984_abnormal_olfaction1.05423786
86MP0002106_abnormal_muscle_physiology1.05133281
87MP0003283_abnormal_digestive_organ1.04678415
88MP0000371_diluted_coat_color1.04358528
89MP0000358_abnormal_cell_content/1.04209333
90MP0002233_abnormal_nose_morphology1.02620276
91MP0005248_abnormal_Harderian_gland1.02589456
92MP0002089_abnormal_postnatal_growth/wei1.02155465
93MP0003385_abnormal_body_wall0.99348840
94MP0005408_hypopigmentation0.95933669
95MP0002282_abnormal_trachea_morphology0.94929260
96MP0000266_abnormal_heart_morphology0.94845593
97MP0006138_congestive_heart_failure0.94023565
98MP0008770_decreased_survivor_rate0.94002070
99MP0004484_altered_response_of0.93151232
100MP0002925_abnormal_cardiovascular_devel0.90875620
101MP0002111_abnormal_tail_morphology0.90528356
102MP0004215_abnormal_myocardial_fiber0.89636650
103MP0005171_absent_coat_pigmentation0.89553750
104MP0002751_abnormal_autonomic_nervous0.88875583
105MP0003861_abnormal_nervous_system0.88836767
106MP0003115_abnormal_respiratory_system0.88691870
107MP0002184_abnormal_innervation0.88047408
108MP0004270_analgesia0.87050712
109MP0005620_abnormal_muscle_contractility0.86390876
110MP0000759_abnormal_skeletal_muscle0.86236167
111MP0002090_abnormal_vision0.85867176
112MP0008057_abnormal_DNA_replication0.85817241
113MP0000428_abnormal_craniofacial_morphol0.85033407
114MP0004858_abnormal_nervous_system0.85004712
115MP0000313_abnormal_cell_death0.84898037
116MP0002092_abnormal_eye_morphology0.84314945
117MP0003786_premature_aging0.83877927
118MP0002938_white_spotting0.83280397
119MP0002697_abnormal_eye_size0.83141122
120MP0003646_muscle_fatigue0.83082443
121MP0001286_abnormal_eye_development0.82477386
122MP0006292_abnormal_olfactory_placode0.82334670
123MP0003942_abnormal_urinary_system0.82257805
124MP0003119_abnormal_digestive_system0.82098685
125MP0003091_abnormal_cell_migration0.81032804
126MP0005197_abnormal_uvea_morphology0.80770473
127MP0000003_abnormal_adipose_tissue0.79858591
128MP0005257_abnormal_intraocular_pressure0.79685617
129MP0005384_cellular_phenotype0.78831127
130MP0005584_abnormal_enzyme/coenzyme_acti0.78629308
131MP0000534_abnormal_ureter_morphology0.78461267
132MP0000579_abnormal_nail_morphology0.78203085
133MP0006054_spinal_hemorrhage0.78114801
134MP0005501_abnormal_skin_physiology0.77332158
135MP0001340_abnormal_eyelid_morphology0.75046384
136MP0004264_abnormal_extraembryonic_tissu0.74840462
137MP0005621_abnormal_cell_physiology0.73879819
138MP0002009_preneoplasia0.73246775
139MP0005369_muscle_phenotype0.73216605
140MP0003172_abnormal_lysosome_physiology0.72967543
141MP0009703_decreased_birth_body0.72756025
142MP0002152_abnormal_brain_morphology0.71560441
143MP0002332_abnormal_exercise_endurance0.69544581
144MP0002019_abnormal_tumor_incidence0.68786907
145MP0005187_abnormal_penis_morphology0.67017065
146MP0000490_abnormal_crypts_of0.66039605

Predicted human phenotypes

RankGene SetZ-score
1Increased serum pyruvate (HP:0003542)4.54052547
2Abnormality of glycolysis (HP:0004366)4.54052547
3Cholecystitis (HP:0001082)4.46613477
4Abnormal gallbladder physiology (HP:0012438)4.46613477
5Ependymoma (HP:0002888)3.70176568
6Abnormal gallbladder morphology (HP:0012437)3.53776244
7Subacute progressive viral hepatitis (HP:0006572)3.47776867
8Cutaneous melanoma (HP:0012056)3.41269528
9* Exercise-induced muscle cramps (HP:0003710)3.38146669
10Adenoma sebaceum (HP:0009720)3.30582212
11Angiofibromas (HP:0010615)3.30582212
12Astrocytoma (HP:0009592)3.10598882
13Abnormality of the astrocytes (HP:0100707)3.10598882
14Spastic diplegia (HP:0001264)3.05814240
15Microvesicular hepatic steatosis (HP:0001414)3.00224761
16Postnatal microcephaly (HP:0005484)2.93751697
17Hypoplastic pelvis (HP:0008839)2.76063671
18Deviation of the thumb (HP:0009603)2.74001756
19Colon cancer (HP:0003003)2.72606805
20Selective tooth agenesis (HP:0001592)2.72188748
21Abnormality of the gallbladder (HP:0005264)2.70669211
22Increased density of long bones (HP:0006392)2.68204205
23Conjunctival hamartoma (HP:0100780)2.67833399
24Agnosia (HP:0010524)2.65956716
25Abnormality of the calcaneus (HP:0008364)2.65938173
26Premature rupture of membranes (HP:0001788)2.64472972
27Metaphyseal cupping (HP:0003021)2.64298323
28Missing ribs (HP:0000921)2.50072152
29Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.48325618
30Upper limb muscle weakness (HP:0003484)2.48176699
31Hypoplasia of the capital femoral epiphysis (HP:0003090)2.45075926
32Atrophy/Degeneration involving motor neurons (HP:0007373)2.43736520
33Proximal placement of thumb (HP:0009623)2.41669020
34Cervical subluxation (HP:0003308)2.40757335
35Neoplasm of the rectum (HP:0100743)2.31415588
36Resting tremor (HP:0002322)2.31405798
37Ovarian neoplasm (HP:0100615)2.31400492
38Centrally nucleated skeletal muscle fibers (HP:0003687)2.29994287
39Vertebral hypoplasia (HP:0008417)2.29978854
40Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.29978854
41Intestinal polyposis (HP:0200008)2.26663027
42Hand muscle atrophy (HP:0009130)2.26551578
43Biliary tract neoplasm (HP:0100574)2.26090356
44Fibroma (HP:0010614)2.25737419
45Pelvic girdle muscle weakness (HP:0003749)2.25224274
46Ulnar deviation of the wrist (HP:0003049)2.25008481
47Freckling (HP:0001480)2.24221138
48Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.22629135
49Absent epiphyses (HP:0010577)2.22629135
50Protrusio acetabuli (HP:0003179)2.22057757
51Upper limb amyotrophy (HP:0009129)2.21904586
52Distal upper limb amyotrophy (HP:0007149)2.21904586
53Insomnia (HP:0100785)2.21438885
54Insidious onset (HP:0003587)2.20343549
55Termporal pattern (HP:0011008)2.20343549
56High anterior hairline (HP:0009890)2.20295867
57* Myoglobinuria (HP:0002913)2.19083572
58* Reticulocytosis (HP:0001923)2.19031652
59Intestinal polyp (HP:0005266)2.19000095
60Fibrous tissue neoplasm (HP:0012316)2.17952024
61Multiple enchondromatosis (HP:0005701)2.17836280
62Shoulder girdle muscle weakness (HP:0003547)2.17086724
63Scapular winging (HP:0003691)2.14846323
64Abnormal neuron morphology (HP:0012757)2.08441676
65Abnormality of the motor neurons (HP:0002450)2.08441676
66Increased nuchal translucency (HP:0010880)2.08372276
67* Rhabdomyolysis (HP:0003201)2.08135682
68Hypopigmentation of the fundus (HP:0007894)2.07871837
69Rhabdomyosarcoma (HP:0002859)2.06585626
70Gout (HP:0001997)2.06479227
71Abnormality of dentin (HP:0010299)2.05975446
72Breech presentation (HP:0001623)2.05220665
73Abnormality of the labia minora (HP:0012880)2.04253699
74Glioma (HP:0009733)2.02260213
75Hyperglycinemia (HP:0002154)2.01562637
76Hamartoma of the eye (HP:0010568)2.00390265
77Type I transferrin isoform profile (HP:0003642)1.99708804
78Limb-girdle muscle atrophy (HP:0003797)1.99258029
79Renal duplication (HP:0000075)1.97644781
80Type 1 muscle fiber predominance (HP:0003803)1.97191781
81Uterine neoplasm (HP:0010784)1.96222894
82Abnormality of the hip-girdle musculature (HP:0001445)1.94316493
83Abnormality of the musculature of the pelvis (HP:0001469)1.94316493
84Hammertoe (HP:0001765)1.92614320
85Entropion (HP:0000621)1.89682593
86Long palpebral fissure (HP:0000637)1.88794136
87Muscle stiffness (HP:0003552)1.87956604
88Neoplasm of the adrenal gland (HP:0100631)1.87368842
89Aplasia/Hypoplasia of the breasts (HP:0010311)1.87201134
90Dysmetric saccades (HP:0000641)1.87061820
91Overlapping toe (HP:0001845)1.86695816
92Increased connective tissue (HP:0009025)1.86243645
93Hyperacusis (HP:0010780)1.85100490
94Ankle contracture (HP:0006466)1.84876353
95Back pain (HP:0003418)1.84824633
96Peripheral hypomyelination (HP:0007182)1.83966688
97Generalized hypotonia (HP:0001290)1.83563353
98Neoplasm of the small intestine (HP:0100833)1.82671167
99Abnormality of the lower motor neuron (HP:0002366)1.82651874
100Melanoma (HP:0002861)1.81977711
101Cortical dysplasia (HP:0002539)1.81710652
102Ragged-red muscle fibers (HP:0003200)1.80305365
103Reduced antithrombin III activity (HP:0001976)1.80045906
104* Abnormality of reticulocytes (HP:0004312)1.79621180
105Exostoses (HP:0100777)1.78162359
106Posterior subcapsular cataract (HP:0007787)1.77040716
107Congenital primary aphakia (HP:0007707)1.76631024
108Abnormal mitochondria in muscle tissue (HP:0008316)1.76447923
109High pitched voice (HP:0001620)1.76045709
110Pseudobulbar signs (HP:0002200)1.75309436
111Broad foot (HP:0001769)1.74339954
112Neoplasm of the colon (HP:0100273)1.74025877
113Exercise-induced myalgia (HP:0003738)1.73839881
114Short humerus (HP:0005792)1.73830534
115Pheochromocytoma (HP:0002666)1.73751995
116Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.72469279
117Decreased activity of mitochondrial respiratory chain (HP:0008972)1.72469279
118Medulloblastoma (HP:0002885)1.72405517
119Orthostatic hypotension (HP:0001278)1.72110249
120Broad alveolar ridges (HP:0000187)1.70912414
121Breast aplasia (HP:0100783)1.70879240
122Nephrogenic diabetes insipidus (HP:0009806)1.70351134
123Delayed puberty (HP:0000823)1.69585807
124Radial bowing (HP:0002986)1.68315373
125CNS hypomyelination (HP:0003429)1.68174072
126Gastrointestinal carcinoma (HP:0002672)1.67733565
127Malignant gastrointestinal tract tumors (HP:0006749)1.67733565
128Gait imbalance (HP:0002141)1.67608303
129Subaortic stenosis (HP:0001682)1.66265625
130Abnormality of the left ventricular outflow tract (HP:0011103)1.66265625
131* Exercise intolerance (HP:0003546)1.65615098
132Broad thumb (HP:0011304)1.65476560
133EMG: myopathic abnormalities (HP:0003458)1.65320426
134Cholelithiasis (HP:0001081)1.65009477
135Basal cell carcinoma (HP:0002671)1.64230438
136Cafe-au-lait spot (HP:0000957)1.63722222
137Trigonocephaly (HP:0000243)1.63152412
138Degeneration of anterior horn cells (HP:0002398)1.63050182
139Abnormality of the anterior horn cell (HP:0006802)1.63050182
140Bilateral sensorineural hearing impairment (HP:0008619)1.62743638
141Micronodular cirrhosis (HP:0001413)1.60837434
142Microglossia (HP:0000171)1.60832289
143Aplasia/hypoplasia of the humerus (HP:0006507)1.60605391
144Abnormality of pain sensation (HP:0010832)1.60508486
145Impaired pain sensation (HP:0007328)1.60508486
146Glossoptosis (HP:0000162)1.59813180
147Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.59680477
148Abnormal protein N-linked glycosylation (HP:0012347)1.59680477
149Abnormal protein glycosylation (HP:0012346)1.59680477
150Abnormal glycosylation (HP:0012345)1.59680477
151Increased serum lactate (HP:0002151)1.58409597
152Ulnar bowing (HP:0003031)1.58408371
153Tetraparesis (HP:0002273)1.57707972
154Cerebral aneurysm (HP:0004944)1.57562463
155Neuroblastic tumors (HP:0004376)1.57427739
156Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.57427739
157Primitive neuroectodermal tumor (HP:0030065)1.57427739
158Dental crowding (HP:0000678)1.56762577
159Irregular epiphyses (HP:0010582)1.55498018
160Impaired proprioception (HP:0010831)1.54576886
161Pterygium (HP:0001059)1.54474932
162Hepatic necrosis (HP:0002605)1.54093240
163Decreased testicular size (HP:0008734)1.53505301
164Cerebral edema (HP:0002181)1.50948402
165Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.50110145
166Facial cleft (HP:0002006)1.49511666
167Prominent metopic ridge (HP:0005487)1.49242081
168Neuroendocrine neoplasm (HP:0100634)1.48783879
169Hepatocellular necrosis (HP:0001404)1.48690840
170Hyperammonemia (HP:0001987)1.48470427
171Pointed chin (HP:0000307)1.47801144
172Poikiloderma (HP:0001029)1.47623399
173Erectile abnormalities (HP:0100639)1.47333027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN26.47593301
2NEK14.40939082
3BCKDK3.45621723
4SRPK13.43296402
5BCR3.09493527
6CDC72.97751839
7EEF2K2.95401559
8TRIB32.95007413
9FLT32.51716045
10WEE12.46568418
11TRIM282.39599686
12SCYL22.27512600
13TTN2.18166480
14CDK192.16869974
15TSSK62.07382489
16NEK22.04417567
17PASK1.77076943
18SIK31.70228193
19VRK21.67329213
20FGFR11.64058994
21OBSCN1.63986492
22LRRK21.62876369
23BMX1.62182945
24MAP2K71.58475701
25TTK1.53319713
26RPS6KB21.48796422
27PAK41.44823574
28BUB11.42277306
29CSNK1G31.39933737
30MAP3K81.38130117
31CSNK1A1L1.38085085
32ERBB31.38044763
33ALK1.36361748
34PLK31.33680029
35CDK121.32536879
36TESK11.30020428
37MAP4K21.29163881
38KSR21.26476577
39MAP3K101.24100121
40LIMK11.23022792
41EPHA21.19701817
42LMTK21.18799947
43CSNK1G21.16520757
44CDK41.11104664
45BRSK21.06986509
46STK101.06745377
47VRK11.06480647
48PTK61.06100174
49TGFBR11.04327037
50CDK61.03681820
51DYRK31.03176909
52PDK31.02816984
53PDK41.02816984
54MST1R0.97164150
55NME20.97117571
56ICK0.96867128
57MET0.96297933
58ILK0.94843002
59EIF2AK10.94210683
60KSR10.94160980
61PLK10.93956233
62AURKB0.93489019
63MAP2K30.91136035
64MAP3K90.87797390
65NTRK10.85029161
66CSNK1G10.84251460
67NEK90.84228960
68PAK20.83960290
69PIM20.83771068
70ATR0.82857942
71PLK20.82008035
72STK30.80355124
73MKNK10.80206891
74PDGFRA0.79008967
75AKT20.77545880
76BRSK10.77500939
77MAP3K40.74388977
78CHEK10.73795823
79MARK10.72294553
80STK38L0.71781089
81DYRK20.70605252
82TESK20.70021890
83LATS20.67835783
84SMG10.65385269
85EPHA30.64491617
86BRAF0.63518133
87DYRK1B0.62854815
88CCNB10.62381638
89PAK10.61914975
90MINK10.61839554
91DAPK10.61788267
92RPS6KA40.61715875
93RIPK10.61221697
94CDK80.61043696
95STK160.60789955
96STK40.60535592
97DDR20.60476095
98RET0.60318605
99FGFR40.59656243
100LATS10.58932039
101RPS6KA50.58036569
102DAPK30.56767815
103EPHA40.56255122
104EPHB10.55601562
105MOS0.54804942
106RAF10.54480094
107SIK20.53505942
108CDK70.52438327
109STK240.52178844
110AURKA0.51749047
111EPHB20.50777136
112PAK60.50190880
113ROCK20.48763778
114CDK20.48514603
115CDK140.47407080
116ARAF0.46515635
117BRD40.46117781
118MELK0.45899729
119CDK150.44988191
120MTOR0.44600033
121GRK60.44513475
122TRPM70.43637088
123CDK180.43305768
124ATM0.42734705
125MARK30.42393623
126FER0.41262605
127NME10.40178897
128PBK0.39743685
129UHMK10.39669451
130CHEK20.39208762
131MAP3K50.38889225
132CDK11A0.36131500
133PTK20.35739916
134MAPKAPK50.35724362
135CDK90.35721764
136PDK20.35604436
137PIM10.35424584
138CDK10.33610281
139CSNK2A20.30035073
140EGFR0.29944708
141CSNK1D0.29527306
142ERBB40.27908871
143EIF2AK30.27569615

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.81155522
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.25454484
3DNA replication_Homo sapiens_hsa030303.12875331
4* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.12083890
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.06317736
6* Biosynthesis of amino acids_Homo sapiens_hsa012303.05953041
7One carbon pool by folate_Homo sapiens_hsa006702.90201253
8* Carbon metabolism_Homo sapiens_hsa012002.76231225
9Central carbon metabolism in cancer_Homo sapiens_hsa052302.68260087
10Mismatch repair_Homo sapiens_hsa034302.63424676
11Steroid biosynthesis_Homo sapiens_hsa001002.50915708
12RNA transport_Homo sapiens_hsa030132.33174611
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.21735158
14Cell cycle_Homo sapiens_hsa041102.02042932
15Fructose and mannose metabolism_Homo sapiens_hsa000511.99602957
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.95046012
17Protein export_Homo sapiens_hsa030601.92992213
18Fatty acid elongation_Homo sapiens_hsa000621.92974128
19Pentose phosphate pathway_Homo sapiens_hsa000301.80992630
20* HIF-1 signaling pathway_Homo sapiens_hsa040661.80963702
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.79828458
22Proteasome_Homo sapiens_hsa030501.74149161
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73655230
24Pyruvate metabolism_Homo sapiens_hsa006201.72220811
25Galactose metabolism_Homo sapiens_hsa000521.66379041
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66304836
27Spliceosome_Homo sapiens_hsa030401.63818551
28Nucleotide excision repair_Homo sapiens_hsa034201.59846883
29Base excision repair_Homo sapiens_hsa034101.39308816
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36673580
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.27350184
32mRNA surveillance pathway_Homo sapiens_hsa030151.22303544
33Ribosome_Homo sapiens_hsa030101.20842592
34Bladder cancer_Homo sapiens_hsa052191.17041147
35Viral carcinogenesis_Homo sapiens_hsa052031.14006440
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11960179
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10309887
38RNA degradation_Homo sapiens_hsa030181.09969439
39mTOR signaling pathway_Homo sapiens_hsa041501.07890976
40Legionellosis_Homo sapiens_hsa051341.02295692
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02118708
42N-Glycan biosynthesis_Homo sapiens_hsa005101.02095484
43Oocyte meiosis_Homo sapiens_hsa041141.02061027
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01082501
45Proteoglycans in cancer_Homo sapiens_hsa052050.98857131
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.96558406
47Fatty acid metabolism_Homo sapiens_hsa012120.95418560
48Arginine and proline metabolism_Homo sapiens_hsa003300.94043172
49p53 signaling pathway_Homo sapiens_hsa041150.92827903
50Cardiac muscle contraction_Homo sapiens_hsa042600.92598545
51MicroRNAs in cancer_Homo sapiens_hsa052060.91560753
52Thyroid cancer_Homo sapiens_hsa052160.91380788
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89559991
54Dilated cardiomyopathy_Homo sapiens_hsa054140.88140781
55Glucagon signaling pathway_Homo sapiens_hsa049220.88095823
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86258587
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84982104
58Small cell lung cancer_Homo sapiens_hsa052220.83453591
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83383404
60Chronic myeloid leukemia_Homo sapiens_hsa052200.83058057
61Vitamin B6 metabolism_Homo sapiens_hsa007500.83000026
62Adherens junction_Homo sapiens_hsa045200.82069804
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81626978
64Focal adhesion_Homo sapiens_hsa045100.77202462
65Viral myocarditis_Homo sapiens_hsa054160.76058412
66Systemic lupus erythematosus_Homo sapiens_hsa053220.75718496
67Hippo signaling pathway_Homo sapiens_hsa043900.74998853
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.74828714
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71844642
70Folate biosynthesis_Homo sapiens_hsa007900.70977726
71HTLV-I infection_Homo sapiens_hsa051660.69056954
72Parkinsons disease_Homo sapiens_hsa050120.69035276
73Tight junction_Homo sapiens_hsa045300.67776456
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66741389
75Colorectal cancer_Homo sapiens_hsa052100.66366329
76Non-homologous end-joining_Homo sapiens_hsa034500.64888014
77Fanconi anemia pathway_Homo sapiens_hsa034600.64667750
78Homologous recombination_Homo sapiens_hsa034400.64176990
79Melanoma_Homo sapiens_hsa052180.63646454
80Epstein-Barr virus infection_Homo sapiens_hsa051690.63640688
81Non-small cell lung cancer_Homo sapiens_hsa052230.62711272
82Glutathione metabolism_Homo sapiens_hsa004800.61600764
83Purine metabolism_Homo sapiens_hsa002300.61459552
84Glioma_Homo sapiens_hsa052140.60386658
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58471076
86Renal cell carcinoma_Homo sapiens_hsa052110.58136213
87Vibrio cholerae infection_Homo sapiens_hsa051100.57689574
88Tyrosine metabolism_Homo sapiens_hsa003500.56990870
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56870466
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56253157
91Alzheimers disease_Homo sapiens_hsa050100.55914810
92Sulfur relay system_Homo sapiens_hsa041220.54053287
93Antigen processing and presentation_Homo sapiens_hsa046120.53240276
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51072002
95* Metabolic pathways_Homo sapiens_hsa011000.50368302
96RNA polymerase_Homo sapiens_hsa030200.48264633
97Endometrial cancer_Homo sapiens_hsa052130.46672086
98Pyrimidine metabolism_Homo sapiens_hsa002400.45681078
99TGF-beta signaling pathway_Homo sapiens_hsa043500.44885149
100Insulin signaling pathway_Homo sapiens_hsa049100.44693009
101Arginine biosynthesis_Homo sapiens_hsa002200.41579343
102Propanoate metabolism_Homo sapiens_hsa006400.41171763
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40970413
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.40464121
105Shigellosis_Homo sapiens_hsa051310.40439510
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39653217
107Phenylalanine metabolism_Homo sapiens_hsa003600.39305965
108Huntingtons disease_Homo sapiens_hsa050160.38803993
109Pancreatic cancer_Homo sapiens_hsa052120.38563107
110Starch and sucrose metabolism_Homo sapiens_hsa005000.38188524
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37963721
112Selenocompound metabolism_Homo sapiens_hsa004500.37123042
113Oxidative phosphorylation_Homo sapiens_hsa001900.37002011
114VEGF signaling pathway_Homo sapiens_hsa043700.36799194
115Alcoholism_Homo sapiens_hsa050340.35328716
116ECM-receptor interaction_Homo sapiens_hsa045120.33116016
117Hepatitis B_Homo sapiens_hsa051610.33022108
118AMPK signaling pathway_Homo sapiens_hsa041520.32316149
119Apoptosis_Homo sapiens_hsa042100.32290485
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32069173
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.31357242
122Axon guidance_Homo sapiens_hsa043600.31134591
123Synaptic vesicle cycle_Homo sapiens_hsa047210.31035935
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29437941
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29207566
126Phagosome_Homo sapiens_hsa041450.27888204
127Salmonella infection_Homo sapiens_hsa051320.27177614
128Peroxisome_Homo sapiens_hsa041460.26675280
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24952000
130Basal transcription factors_Homo sapiens_hsa030220.24679557
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20836761
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.19738810
133Lysine degradation_Homo sapiens_hsa003100.18312424

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