PGK1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.98057152
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.03413978
3proteasome assembly (GO:0043248)5.43893376
4cytidine metabolic process (GO:0046087)5.29037768
5cytidine catabolic process (GO:0006216)5.29037768
6cytidine deamination (GO:0009972)5.29037768
7sequestering of actin monomers (GO:0042989)5.27274561
8regulation of activation of Janus kinase activity (GO:0010533)4.75480355
9pyrimidine ribonucleoside catabolic process (GO:0046133)4.65881877
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.45033813
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.31517587
12ATP synthesis coupled proton transport (GO:0015986)4.31517587
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.18036107
14regulation of cellular amino acid metabolic process (GO:0006521)4.02614640
15protein neddylation (GO:0045116)3.96443628
16protein deneddylation (GO:0000338)3.95470548
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.93329205
18positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.86401051
19DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.84079463
20cornea development in camera-type eye (GO:0061303)3.82395910
21negative regulation of T cell apoptotic process (GO:0070233)3.81964706
22signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.73009270
23signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.73009270
24signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.73009270
25intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.71920892
26signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.71920892
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.70478781
28negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.68822714
29negative regulation of ligase activity (GO:0051352)3.68822714
30positive regulation of defense response to virus by host (GO:0002230)3.64565692
31protein complex biogenesis (GO:0070271)3.59149144
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.58712338
33negative regulation of thymocyte apoptotic process (GO:0070244)3.57961920
34signal transduction involved in cell cycle checkpoint (GO:0072395)3.55482917
35signal transduction involved in DNA damage checkpoint (GO:0072422)3.54038415
36signal transduction involved in DNA integrity checkpoint (GO:0072401)3.54038415
37anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.42648648
38cullin deneddylation (GO:0010388)3.40702177
39respiratory electron transport chain (GO:0022904)3.38124548
40cellular response to interleukin-15 (GO:0071350)3.34725084
41electron transport chain (GO:0022900)3.33088077
42positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.32233301
43negative regulation of telomere maintenance (GO:0032205)3.30899886
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.29263316
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.28036119
46tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.28036119
47Arp2/3 complex-mediated actin nucleation (GO:0034314)3.27019920
48positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.23445713
49negative regulation by host of viral transcription (GO:0043922)3.21768111
50NADH dehydrogenase complex assembly (GO:0010257)3.21484400
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21484400
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.21484400
53chaperone-mediated protein transport (GO:0072321)3.19164762
54nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15264562
55mitochondrial respiratory chain complex assembly (GO:0033108)3.13664527
56protein-cofactor linkage (GO:0018065)3.11920748
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11200104
58platelet dense granule organization (GO:0060155)3.11056067
59positive regulation of ligase activity (GO:0051351)3.10977837
60antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.05984026
61negative regulation of lymphocyte apoptotic process (GO:0070229)3.05777925
62DNA damage response, detection of DNA damage (GO:0042769)3.01401878
63regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.97338213
64mannosylation (GO:0097502)2.93045102
65DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.90819899
66regulation of defense response to virus by host (GO:0050691)2.86768809
67regulation of cellular amine metabolic process (GO:0033238)2.85973434
68positive regulation of cell cycle arrest (GO:0071158)2.85587481
69actin nucleation (GO:0045010)2.84881766
70GPI anchor metabolic process (GO:0006505)2.83618775
71GPI anchor biosynthetic process (GO:0006506)2.82295687
72activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.81530841
73L-fucose catabolic process (GO:0042355)2.76830840
74fucose catabolic process (GO:0019317)2.76830840
75L-fucose metabolic process (GO:0042354)2.76830840
76positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.76723837
77ribosomal small subunit assembly (GO:0000028)2.75853309
78aldehyde catabolic process (GO:0046185)2.74050348
79regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.73145781
80signal peptide processing (GO:0006465)2.71563805
81T cell migration (GO:0072678)2.67470861
82regulation of ubiquitin-protein transferase activity (GO:0051438)2.66480361
83regulation of T cell receptor signaling pathway (GO:0050856)2.65799226
84rRNA modification (GO:0000154)2.63733077
85metallo-sulfur cluster assembly (GO:0031163)2.63609739
86iron-sulfur cluster assembly (GO:0016226)2.63609739
87regulation of ligase activity (GO:0051340)2.58538773
88antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.58034292
89positive regulation of mitochondrial fission (GO:0090141)2.57584679
90regulation of timing of cell differentiation (GO:0048505)2.57518127
91regulation of development, heterochronic (GO:0040034)2.57490020
92response to interleukin-15 (GO:0070672)2.55724299
93GTP biosynthetic process (GO:0006183)2.54235533
94tryptophan metabolic process (GO:0006568)2.50789669
95regulation of regulatory T cell differentiation (GO:0045589)2.50709479
96nucleotide transmembrane transport (GO:1901679)2.50249225
97pyrimidine ribonucleoside metabolic process (GO:0046131)2.48383190
98protein peptidyl-prolyl isomerization (GO:0000413)2.47553218
99positive regulation of alpha-beta T cell proliferation (GO:0046641)2.47307004
100hydrogen ion transmembrane transport (GO:1902600)2.45827227

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.29163333
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.28003341
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.99640739
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.89331107
5VDR_22108803_ChIP-Seq_LS180_Human3.70862729
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.57884311
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.23807665
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.98170480
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90465283
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.89047856
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.83840665
12VDR_23849224_ChIP-Seq_CD4+_Human2.65747071
13ZNF274_21170338_ChIP-Seq_K562_Hela2.48044199
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.38087201
15ELK1_19687146_ChIP-ChIP_HELA_Human2.29465151
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.27625265
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.24635826
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.24436365
19FOXP3_21729870_ChIP-Seq_TREG_Human2.15937988
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.14840099
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.12536820
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11793024
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.07774319
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97933961
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.96172338
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.88570664
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.85054952
28MYC_18940864_ChIP-ChIP_HL60_Human1.73478070
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69384954
30IRF1_19129219_ChIP-ChIP_H3396_Human1.68924031
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61786632
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60143993
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58591307
34TAF15_26573619_Chip-Seq_HEK293_Human1.55058299
35TP53_22573176_ChIP-Seq_HFKS_Human1.51891850
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48585357
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.47183193
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46956123
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45757008
40AR_20517297_ChIP-Seq_VCAP_Human1.43659712
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.42018366
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39957231
43EWS_26573619_Chip-Seq_HEK293_Human1.39647038
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.38937189
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37066753
46DCP1A_22483619_ChIP-Seq_HELA_Human1.32768690
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30183947
48FUS_26573619_Chip-Seq_HEK293_Human1.29291533
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28766271
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25992666
51MYB_26560356_Chip-Seq_TH2_Human1.24099288
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.24055017
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24055017
54IGF1R_20145208_ChIP-Seq_DFB_Human1.23984758
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22339869
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20953928
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20736708
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19702037
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18722985
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18244672
61PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.17119215
62MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16736814
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13970865
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13157513
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12902714
66P300_19829295_ChIP-Seq_ESCs_Human1.12380401
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09098654
68SOX2_16153702_ChIP-ChIP_HESCs_Human1.08573305
69AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08296733
70EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07577761
71GATA3_26560356_Chip-Seq_TH2_Human1.06523147
72GABP_19822575_ChIP-Seq_HepG2_Human1.06329337
73CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06014286
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05365464
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05015418
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.04379177
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03605483
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.03017459
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02083475
80NCOR_22424771_ChIP-Seq_293T_Human1.01766486
81SOX2_19829295_ChIP-Seq_ESCs_Human1.01452973
82NANOG_19829295_ChIP-Seq_ESCs_Human1.01452973
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00688641
84TTF2_22483619_ChIP-Seq_HELA_Human0.99993286
85CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98628680
86RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97121387
87NANOG_20526341_ChIP-Seq_ESCs_Human0.96948051
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.92755197
89HTT_18923047_ChIP-ChIP_STHdh_Human0.92646789
90ERG_20517297_ChIP-Seq_VCAP_Human0.92368743
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92149141
92EZH2_27294783_Chip-Seq_NPCs_Mouse0.91997160
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91885696
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88660159
95MYC_19829295_ChIP-Seq_ESCs_Human0.88628827
96TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87837529
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87647233
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.87062301
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86714243
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86321917

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.12739235
2MP0005671_abnormal_response_to4.12802289
3MP0008789_abnormal_olfactory_epithelium3.49435853
4MP0002638_abnormal_pupillary_reflex2.79603251
5MP0005499_abnormal_olfactory_system2.76457455
6MP0005394_taste/olfaction_phenotype2.76457455
7MP0009785_altered_susceptibility_to2.73052537
8MP0006072_abnormal_retinal_apoptosis2.64779365
9MP0001835_abnormal_antigen_presentation2.57922891
10MP0005257_abnormal_intraocular_pressure2.49130832
11MP0002102_abnormal_ear_morphology2.26013779
12MP0002822_catalepsy2.13228226
13MP0001529_abnormal_vocalization2.12249315
14MP0001905_abnormal_dopamine_level2.01165500
15MP0000372_irregular_coat_pigmentation1.99465224
16MP0002148_abnormal_hypersensitivity_rea1.85485499
17MP0003880_abnormal_central_pattern1.78308401
18MP0004145_abnormal_muscle_electrophysio1.78280794
19MP0005084_abnormal_gallbladder_morpholo1.74508143
20MP0009333_abnormal_splenocyte_physiolog1.72846473
21MP0008877_abnormal_DNA_methylation1.71785845
22MP0005000_abnormal_immune_tolerance1.63423281
23MP0001790_abnormal_immune_system1.62349906
24MP0005387_immune_system_phenotype1.62349906
25MP0005253_abnormal_eye_physiology1.61844701
26MP0004147_increased_porphyrin_level1.61742842
27MP0002938_white_spotting1.61620143
28MP0002736_abnormal_nociception_after1.59382600
29MP0008872_abnormal_physiological_respon1.58044348
30MP0005551_abnormal_eye_electrophysiolog1.54290239
31MP0008875_abnormal_xenobiotic_pharmacok1.48902566
32MP0002653_abnormal_ependyma_morphology1.46973726
33MP0002166_altered_tumor_susceptibility1.46839880
34MP0001800_abnormal_humoral_immune1.46652946
35MP0001968_abnormal_touch/_nociception1.41302579
36MP0003786_premature_aging1.40787194
37MP0008058_abnormal_DNA_repair1.39866228
38MP0010386_abnormal_urinary_bladder1.39795228
39MP0003195_calcinosis1.38064948
40MP0005645_abnormal_hypothalamus_physiol1.34947930
41MP0002723_abnormal_immune_serum1.34745506
42MP0002277_abnormal_respiratory_mucosa1.34327141
43MP0003866_abnormal_defecation1.29284101
44MP0002933_joint_inflammation1.27884880
45MP0003763_abnormal_thymus_physiology1.24441551
46MP0002006_tumorigenesis1.24282800
47MP0001919_abnormal_reproductive_system1.23319494
48MP0002420_abnormal_adaptive_immunity1.23024262
49MP0001819_abnormal_immune_cell1.19827559
50MP0000613_abnormal_salivary_gland1.19472999
51MP0002234_abnormal_pharynx_morphology1.17479907
52MP0002837_dystrophic_cardiac_calcinosis1.15204157
53MP0010155_abnormal_intestine_physiology1.13910427
54MP0005025_abnormal_response_to1.13543698
55MP0000538_abnormal_urinary_bladder1.11143430
56MP0001984_abnormal_olfaction1.10203361
57MP0006036_abnormal_mitochondrial_physio1.10000134
58MP0002452_abnormal_antigen_presenting1.01284758
59MP0004885_abnormal_endolymph1.00634767
60MP0002751_abnormal_autonomic_nervous0.98344530
61MP0005075_abnormal_melanosome_morpholog0.96395863
62MP0005389_reproductive_system_phenotype0.94693521
63MP0004133_heterotaxia0.93908393
64MP0005360_urolithiasis0.93146689
65MP0000689_abnormal_spleen_morphology0.90613933
66MP0002722_abnormal_immune_system0.90104051
67MP0002160_abnormal_reproductive_system0.89478681
68MP0008995_early_reproductive_senescence0.88535704
69MP0001845_abnormal_inflammatory_respons0.87913743
70MP0004142_abnormal_muscle_tone0.87015175
71MP0000716_abnormal_immune_system0.85856480
72MP0003724_increased_susceptibility_to0.85617629
73MP0002282_abnormal_trachea_morphology0.85408832
74MP0000049_abnormal_middle_ear0.84412801
75MP0005410_abnormal_fertilization0.81636116
76MP0002876_abnormal_thyroid_physiology0.80109669
77MP0002272_abnormal_nervous_system0.78575926
78MP0003045_fibrosis0.78229133
79MP0000703_abnormal_thymus_morphology0.75962267
80MP0003137_abnormal_impulse_conducting0.73443209
81MP0002398_abnormal_bone_marrow0.73412444
82MP0005377_hearing/vestibular/ear_phenot0.72995980
83MP0003878_abnormal_ear_physiology0.72995980
84MP0009046_muscle_twitch0.72568957
85MP0002405_respiratory_system_inflammati0.72474940
86MP0005391_vision/eye_phenotype0.72143546
87MP0003011_delayed_dark_adaptation0.70640565
88MP0006276_abnormal_autonomic_nervous0.69930266
89MP0003938_abnormal_ear_development0.69587477
90MP0000685_abnormal_immune_system0.68089922
91MP0004924_abnormal_behavior0.67288738
92MP0005386_behavior/neurological_phenoty0.67288738
93MP0005379_endocrine/exocrine_gland_phen0.66552050
94MP0009764_decreased_sensitivity_to0.66150318
95MP0000647_abnormal_sebaceous_gland0.64974917
96MP0001873_stomach_inflammation0.64475142
97MP0002693_abnormal_pancreas_physiology0.63949202
98MP0001293_anophthalmia0.62876723
99MP0002138_abnormal_hepatobiliary_system0.62781957
100MP0002429_abnormal_blood_cell0.62614571

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)4.33744087
2Acute necrotizing encephalopathy (HP:0006965)4.01452576
3IgG deficiency (HP:0004315)3.91227025
4Abnormal mitochondria in muscle tissue (HP:0008316)3.89049230
5Mitochondrial inheritance (HP:0001427)3.79104067
6Generalized aminoaciduria (HP:0002909)3.70151728
7Hypoplasia of the fovea (HP:0007750)3.67867562
8Aplasia/Hypoplasia of the fovea (HP:0008060)3.67867562
9T lymphocytopenia (HP:0005403)3.67055974
10Hypoproteinemia (HP:0003075)3.62169196
11Thyroiditis (HP:0100646)3.54071810
12Increased CSF lactate (HP:0002490)3.51938077
13Aplastic anemia (HP:0001915)3.50907930
14Hepatic necrosis (HP:0002605)3.50617791
15Renal cortical cysts (HP:0000803)3.48485972
16Hepatocellular necrosis (HP:0001404)3.45004468
17Combined immunodeficiency (HP:0005387)3.37830527
18Abnormality of the fovea (HP:0000493)3.32156783
193-Methylglutaconic aciduria (HP:0003535)3.28129205
20Progressive macrocephaly (HP:0004481)3.26474456
21Acute encephalopathy (HP:0006846)3.21713299
22Increased hepatocellular lipid droplets (HP:0006565)3.18040848
23Abnormality of T cell number (HP:0011839)3.15054900
24Lipid accumulation in hepatocytes (HP:0006561)3.09954210
25Abolished electroretinogram (ERG) (HP:0000550)3.09781251
26Increased intramyocellular lipid droplets (HP:0012240)2.99479788
27Abnormality of eosinophils (HP:0001879)2.88369096
28Renal Fanconi syndrome (HP:0001994)2.87725786
29Cerebral edema (HP:0002181)2.87725418
30Congenital stationary night blindness (HP:0007642)2.87543662
31B lymphocytopenia (HP:0010976)2.80669533
32Stomatitis (HP:0010280)2.74475386
33Type I transferrin isoform profile (HP:0003642)2.70731599
34Increased serum lactate (HP:0002151)2.62151162
35Abnormality of the renal cortex (HP:0011035)2.57388375
36Panhypogammaglobulinemia (HP:0003139)2.56386487
37Increased muscle lipid content (HP:0009058)2.55340806
38Abnormality of B cell number (HP:0010975)2.54867164
39Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51695764
40Abnormal protein N-linked glycosylation (HP:0012347)2.51695764
41Abnormal protein glycosylation (HP:0012346)2.51695764
42Abnormal glycosylation (HP:0012345)2.51695764
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.51643174
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.51643174
45Pancreatic cysts (HP:0001737)2.51180516
46Lactic acidosis (HP:0003128)2.49122592
47Abnormality of T cells (HP:0002843)2.46863838
48Elevated erythrocyte sedimentation rate (HP:0003565)2.45637338
49Optic disc pallor (HP:0000543)2.38578828
50Hypothermia (HP:0002045)2.36451974
51Aplasia/hypoplasia of the uterus (HP:0008684)2.36243706
52Oral leukoplakia (HP:0002745)2.35150322
53Increased IgM level (HP:0003496)2.31695533
54IgM deficiency (HP:0002850)2.31188613
55Eosinophilia (HP:0001880)2.29494557
56Molar tooth sign on MRI (HP:0002419)2.28218077
57Abnormality of midbrain morphology (HP:0002418)2.28218077
58Optic nerve hypoplasia (HP:0000609)2.21757940
59Reduced antithrombin III activity (HP:0001976)2.20868748
60Exertional dyspnea (HP:0002875)2.19099170
61Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.18827618
62Abnormality of the prostate (HP:0008775)2.18559988
63Exercise-induced muscle cramps (HP:0003710)2.14012124
64Exercise intolerance (HP:0003546)2.12181284
65True hermaphroditism (HP:0010459)2.06463272
66Respiratory failure (HP:0002878)2.05368138
67Aplasia/Hypoplasia of the macula (HP:0008059)2.03606947
68Hypoplasia of the thymus (HP:0000778)2.02958009
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99147925
70Abnormality of alanine metabolism (HP:0010916)1.99147925
71Hyperalaninemia (HP:0003348)1.99147925
72Glycosuria (HP:0003076)1.98510192
73Abnormality of urine glucose concentration (HP:0011016)1.98510192
74Nephronophthisis (HP:0000090)1.97412077
75Tongue fasciculations (HP:0001308)1.95573018
76Methylmalonic acidemia (HP:0002912)1.95253003
77Aplasia/Hypoplasia affecting the retina (HP:0008061)1.93535827
78Medial flaring of the eyebrow (HP:0010747)1.93053356
79Absent rod-and cone-mediated responses on ERG (HP:0007688)1.89245862
80Pancytopenia (HP:0001876)1.88243674
81Attenuation of retinal blood vessels (HP:0007843)1.87110153
82Cellular immunodeficiency (HP:0005374)1.86533049
83Lethargy (HP:0001254)1.85333678
84Abnormal rod and cone electroretinograms (HP:0008323)1.84444335
85Dicarboxylic aciduria (HP:0003215)1.83401300
86Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83401300
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.81689655
88Pancreatic fibrosis (HP:0100732)1.78891860
89Septo-optic dysplasia (HP:0100842)1.77796333
90Abnormality of renal resorption (HP:0011038)1.77364851
91Encephalitis (HP:0002383)1.76809085
92Parakeratosis (HP:0001036)1.75160525
93Pendular nystagmus (HP:0012043)1.75106627
94Abnormality of the renal medulla (HP:0100957)1.73579110
95Abnormality of macular pigmentation (HP:0008002)1.72978655
96Decreased electroretinogram (ERG) amplitude (HP:0000654)1.72393610
97CNS hypomyelination (HP:0003429)1.71849325
98Leukocytosis (HP:0001974)1.71784743
99Hyperglycinuria (HP:0003108)1.68496846
100Fibular aplasia (HP:0002990)1.67899790

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.56247493
2BCKDK3.44197150
3TESK23.42316792
4VRK23.12975601
5BUB13.03892870
6KDR2.75203405
7TLK12.65635107
8STK162.54178314
9TAOK32.43326574
10MAP4K22.39207862
11ZAK2.07896619
12NUAK12.00919124
13ADRBK21.89867315
14MAP3K121.88183505
15MAPK131.86476933
16MAP4K11.75678348
17SRPK11.73543762
18WNK31.72697813
19VRK11.70935936
20TESK11.70081934
21LIMK11.68095393
22ITK1.61646153
23NME11.48757753
24CDK191.45544683
25GRK11.42534444
26WNK41.40806015
27TIE11.30207241
28FES1.27889597
29PHKG21.21196814
30PHKG11.21196814
31DAPK11.20070600
32CSNK1G31.17663986
33PTK2B1.15299142
34TEC1.12201519
35EIF2AK31.08279162
36GRK61.08174157
37MAPKAPK31.04556999
38TRIM281.04036596
39MST41.01923589
40BMPR1B0.98020069
41PINK10.97727369
42DYRK20.94912396
43CSNK1G20.94443913
44CSNK1G10.92054451
45FRK0.86408732
46PRKCQ0.83950522
47CSNK1A1L0.83497638
48ERBB30.82209806
49SYK0.78124839
50MAP2K70.76066251
51OXSR10.75634222
52FLT30.71906595
53CCNB10.70183471
54PLK20.68349949
55KIT0.67267271
56IKBKB0.67131037
57IKBKE0.67122974
58RPS6KA50.67017627
59INSRR0.66905377
60MUSK0.64594486
61EIF2AK20.64227842
62PLK30.64161345
63LCK0.63738577
64TBK10.62734753
65MYLK0.59451430
66HIPK20.59232639
67LMTK20.57641620
68MAP2K60.54833849
69TSSK60.53697791
70MAPKAPK50.48786703
71OBSCN0.48241435
72JAK30.48200933
73LYN0.45426463
74CSK0.45347551
75MATK0.44324865
76CAMKK20.43977333
77AURKA0.43728831
78MAP3K110.43375029
79FER0.42572432
80BCR0.41697047
81ILK0.41112731
82PIK3CG0.40956573
83CSNK1A10.40474622
84GRK70.37984974
85CSNK2A10.37878352
86MKNK10.37538982
87PRKCE0.36510998
88CDK80.35364972
89MAP2K20.34898906
90CSF1R0.33988889
91STK38L0.33553891
92IGF1R0.32821855
93BTK0.32363223
94GRK50.27456590
95PLK40.27319969
96PAK10.25990319
97CAMK2A0.25961460
98PRKACA0.25018806
99EIF2AK10.24917969
100NEK10.24821428

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.37569786
2Primary immunodeficiency_Homo sapiens_hsa053403.66869254
3Oxidative phosphorylation_Homo sapiens_hsa001903.57117841
4Parkinsons disease_Homo sapiens_hsa050123.20681771
5Protein export_Homo sapiens_hsa030602.82484028
6Graft-versus-host disease_Homo sapiens_hsa053322.00419906
7Allograft rejection_Homo sapiens_hsa053301.99788008
8RNA polymerase_Homo sapiens_hsa030201.95686218
9Autoimmune thyroid disease_Homo sapiens_hsa053201.90922915
10Alzheimers disease_Homo sapiens_hsa050101.89170638
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85772362
12Ribosome_Homo sapiens_hsa030101.82664516
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82653378
14Phototransduction_Homo sapiens_hsa047441.81485558
15Caffeine metabolism_Homo sapiens_hsa002321.79988971
16Antigen processing and presentation_Homo sapiens_hsa046121.79902450
17Fatty acid elongation_Homo sapiens_hsa000621.75521442
18Huntingtons disease_Homo sapiens_hsa050161.73177888
19Mismatch repair_Homo sapiens_hsa034301.70790199
20Type I diabetes mellitus_Homo sapiens_hsa049401.58906095
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.49855689
22Rheumatoid arthritis_Homo sapiens_hsa053231.41129395
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40872389
24DNA replication_Homo sapiens_hsa030301.38300248
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36679526
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35963155
27Asthma_Homo sapiens_hsa053101.31442252
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29339174
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.25531876
30Cardiac muscle contraction_Homo sapiens_hsa042601.25452004
31RNA degradation_Homo sapiens_hsa030181.19279463
32Propanoate metabolism_Homo sapiens_hsa006401.18916228
33Folate biosynthesis_Homo sapiens_hsa007901.17938696
34Homologous recombination_Homo sapiens_hsa034401.14339426
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13950586
36Systemic lupus erythematosus_Homo sapiens_hsa053221.10226184
37Hematopoietic cell lineage_Homo sapiens_hsa046401.07656293
38Spliceosome_Homo sapiens_hsa030401.06725557
39Nitrogen metabolism_Homo sapiens_hsa009101.05004739
40Sulfur metabolism_Homo sapiens_hsa009201.04144503
41Steroid biosynthesis_Homo sapiens_hsa001001.03141240
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03137379
43Nucleotide excision repair_Homo sapiens_hsa034201.00110228
44Pyrimidine metabolism_Homo sapiens_hsa002400.99378151
45Regulation of autophagy_Homo sapiens_hsa041400.99095036
46Basal transcription factors_Homo sapiens_hsa030220.95219685
47Tryptophan metabolism_Homo sapiens_hsa003800.93851595
48Collecting duct acid secretion_Homo sapiens_hsa049660.92080297
49Non-homologous end-joining_Homo sapiens_hsa034500.90780890
50Fanconi anemia pathway_Homo sapiens_hsa034600.90444354
51Purine metabolism_Homo sapiens_hsa002300.90079963
52T cell receptor signaling pathway_Homo sapiens_hsa046600.89956327
53Base excision repair_Homo sapiens_hsa034100.85038603
54Peroxisome_Homo sapiens_hsa041460.83839729
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77746611
56RNA transport_Homo sapiens_hsa030130.75749027
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72497345
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72166027
59Measles_Homo sapiens_hsa051620.70037105
60Glutathione metabolism_Homo sapiens_hsa004800.68761933
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68198691
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68120862
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66467254
64Linoleic acid metabolism_Homo sapiens_hsa005910.64299993
65Biosynthesis of amino acids_Homo sapiens_hsa012300.63475006
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63417007
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62522156
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61529903
69Chemical carcinogenesis_Homo sapiens_hsa052040.60632917
70Butanoate metabolism_Homo sapiens_hsa006500.58450099
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57116787
72Viral myocarditis_Homo sapiens_hsa054160.55031619
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.54133693
74Carbon metabolism_Homo sapiens_hsa012000.53762367
75Metabolic pathways_Homo sapiens_hsa011000.51252209
76Legionellosis_Homo sapiens_hsa051340.50455840
77Selenocompound metabolism_Homo sapiens_hsa004500.50117103
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49432416
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48968478
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48932665
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48635877
82Alcoholism_Homo sapiens_hsa050340.46307037
83Pyruvate metabolism_Homo sapiens_hsa006200.45838819
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45320216
85Shigellosis_Homo sapiens_hsa051310.43871539
86One carbon pool by folate_Homo sapiens_hsa006700.43689209
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42800997
88Pentose phosphate pathway_Homo sapiens_hsa000300.42749815
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42309665
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42190506
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40780370
92N-Glycan biosynthesis_Homo sapiens_hsa005100.39721644
93Retinol metabolism_Homo sapiens_hsa008300.39022389
94Arachidonic acid metabolism_Homo sapiens_hsa005900.38999534
95Sulfur relay system_Homo sapiens_hsa041220.38470057
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.38090739
97Epstein-Barr virus infection_Homo sapiens_hsa051690.37906900
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.37537296
99Fatty acid degradation_Homo sapiens_hsa000710.34425842
100Vibrio cholerae infection_Homo sapiens_hsa051100.31459976

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »