

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 6.98057152 |
| 2 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 6.03413978 |
| 3 | proteasome assembly (GO:0043248) | 5.43893376 |
| 4 | cytidine metabolic process (GO:0046087) | 5.29037768 |
| 5 | cytidine catabolic process (GO:0006216) | 5.29037768 |
| 6 | cytidine deamination (GO:0009972) | 5.29037768 |
| 7 | sequestering of actin monomers (GO:0042989) | 5.27274561 |
| 8 | regulation of activation of Janus kinase activity (GO:0010533) | 4.75480355 |
| 9 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 4.65881877 |
| 10 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.45033813 |
| 11 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.31517587 |
| 12 | ATP synthesis coupled proton transport (GO:0015986) | 4.31517587 |
| 13 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.18036107 |
| 14 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.02614640 |
| 15 | protein neddylation (GO:0045116) | 3.96443628 |
| 16 | protein deneddylation (GO:0000338) | 3.95470548 |
| 17 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.93329205 |
| 18 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.86401051 |
| 19 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.84079463 |
| 20 | cornea development in camera-type eye (GO:0061303) | 3.82395910 |
| 21 | negative regulation of T cell apoptotic process (GO:0070233) | 3.81964706 |
| 22 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.73009270 |
| 23 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.73009270 |
| 24 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.73009270 |
| 25 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.71920892 |
| 26 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.71920892 |
| 27 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.70478781 |
| 28 | negative regulation of ligase activity (GO:0051352) | 3.68822714 |
| 29 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.68822714 |
| 30 | positive regulation of defense response to virus by host (GO:0002230) | 3.64565692 |
| 31 | protein complex biogenesis (GO:0070271) | 3.59149144 |
| 32 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.58712338 |
| 33 | negative regulation of thymocyte apoptotic process (GO:0070244) | 3.57961920 |
| 34 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.55482917 |
| 35 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.54038415 |
| 36 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.54038415 |
| 37 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.42648648 |
| 38 | cullin deneddylation (GO:0010388) | 3.40702177 |
| 39 | respiratory electron transport chain (GO:0022904) | 3.38124548 |
| 40 | cellular response to interleukin-15 (GO:0071350) | 3.34725084 |
| 41 | electron transport chain (GO:0022900) | 3.33088077 |
| 42 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.32233301 |
| 43 | negative regulation of telomere maintenance (GO:0032205) | 3.30899886 |
| 44 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.29263316 |
| 45 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.28036119 |
| 46 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.28036119 |
| 47 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.27019920 |
| 48 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.23445713 |
| 49 | negative regulation by host of viral transcription (GO:0043922) | 3.21768111 |
| 50 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.21484400 |
| 51 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.21484400 |
| 52 | NADH dehydrogenase complex assembly (GO:0010257) | 3.21484400 |
| 53 | chaperone-mediated protein transport (GO:0072321) | 3.19164762 |
| 54 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.15264562 |
| 55 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.13664527 |
| 56 | protein-cofactor linkage (GO:0018065) | 3.11920748 |
| 57 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.11200104 |
| 58 | platelet dense granule organization (GO:0060155) | 3.11056067 |
| 59 | positive regulation of ligase activity (GO:0051351) | 3.10977837 |
| 60 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.05984026 |
| 61 | negative regulation of lymphocyte apoptotic process (GO:0070229) | 3.05777925 |
| 62 | DNA damage response, detection of DNA damage (GO:0042769) | 3.01401878 |
| 63 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 2.97338213 |
| 64 | mannosylation (GO:0097502) | 2.93045102 |
| 65 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.90819899 |
| 66 | regulation of defense response to virus by host (GO:0050691) | 2.86768809 |
| 67 | regulation of cellular amine metabolic process (GO:0033238) | 2.85973434 |
| 68 | positive regulation of cell cycle arrest (GO:0071158) | 2.85587481 |
| 69 | actin nucleation (GO:0045010) | 2.84881766 |
| 70 | GPI anchor metabolic process (GO:0006505) | 2.83618775 |
| 71 | GPI anchor biosynthetic process (GO:0006506) | 2.82295687 |
| 72 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO | 2.81530841 |
| 73 | L-fucose catabolic process (GO:0042355) | 2.76830840 |
| 74 | fucose catabolic process (GO:0019317) | 2.76830840 |
| 75 | L-fucose metabolic process (GO:0042354) | 2.76830840 |
| 76 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 2.76723837 |
| 77 | ribosomal small subunit assembly (GO:0000028) | 2.75853309 |
| 78 | aldehyde catabolic process (GO:0046185) | 2.74050348 |
| 79 | regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108) | 2.73145781 |
| 80 | signal peptide processing (GO:0006465) | 2.71563805 |
| 81 | T cell migration (GO:0072678) | 2.67470861 |
| 82 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.66480361 |
| 83 | regulation of T cell receptor signaling pathway (GO:0050856) | 2.65799226 |
| 84 | rRNA modification (GO:0000154) | 2.63733077 |
| 85 | metallo-sulfur cluster assembly (GO:0031163) | 2.63609739 |
| 86 | iron-sulfur cluster assembly (GO:0016226) | 2.63609739 |
| 87 | regulation of ligase activity (GO:0051340) | 2.58538773 |
| 88 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.58034292 |
| 89 | positive regulation of mitochondrial fission (GO:0090141) | 2.57584679 |
| 90 | regulation of timing of cell differentiation (GO:0048505) | 2.57518127 |
| 91 | regulation of development, heterochronic (GO:0040034) | 2.57490020 |
| 92 | response to interleukin-15 (GO:0070672) | 2.55724299 |
| 93 | GTP biosynthetic process (GO:0006183) | 2.54235533 |
| 94 | tryptophan metabolic process (GO:0006568) | 2.50789669 |
| 95 | regulation of regulatory T cell differentiation (GO:0045589) | 2.50709479 |
| 96 | nucleotide transmembrane transport (GO:1901679) | 2.50249225 |
| 97 | pyrimidine ribonucleoside metabolic process (GO:0046131) | 2.48383190 |
| 98 | protein peptidyl-prolyl isomerization (GO:0000413) | 2.47553218 |
| 99 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 2.47307004 |
| 100 | hydrogen ion transmembrane transport (GO:1902600) | 2.45827227 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.29163333 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.28003341 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.99640739 |
| 4 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 3.89331107 |
| 5 | VDR_22108803_ChIP-Seq_LS180_Human | 3.70862729 |
| 6 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.57884311 |
| 7 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.23807665 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.98170480 |
| 9 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.90465283 |
| 10 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.89047856 |
| 11 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.83840665 |
| 12 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.65747071 |
| 13 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.48044199 |
| 14 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.38087201 |
| 15 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.29465151 |
| 16 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.27625265 |
| 17 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.24635826 |
| 18 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.24436365 |
| 19 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.15937988 |
| 20 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.14840099 |
| 21 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.12536820 |
| 22 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.11793024 |
| 23 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.07774319 |
| 24 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.97933961 |
| 25 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.96172338 |
| 26 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.88570664 |
| 27 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.85054952 |
| 28 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.73478070 |
| 29 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.69384954 |
| 30 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.68924031 |
| 31 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.61786632 |
| 32 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.60143993 |
| 33 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.58591307 |
| 34 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.55058299 |
| 35 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.51891850 |
| 36 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.48585357 |
| 37 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.47183193 |
| 38 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.46956123 |
| 39 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.45757008 |
| 40 | AR_20517297_ChIP-Seq_VCAP_Human | 1.43659712 |
| 41 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.42018366 |
| 42 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.39957231 |
| 43 | EWS_26573619_Chip-Seq_HEK293_Human | 1.39647038 |
| 44 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.38937189 |
| 45 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.37066753 |
| 46 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.32768690 |
| 47 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.30183947 |
| 48 | FUS_26573619_Chip-Seq_HEK293_Human | 1.29291533 |
| 49 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.28766271 |
| 50 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.25992666 |
| 51 | MYB_26560356_Chip-Seq_TH2_Human | 1.24099288 |
| 52 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.24055017 |
| 53 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.24055017 |
| 54 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.23984758 |
| 55 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.22339869 |
| 56 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.20953928 |
| 57 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.20736708 |
| 58 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.19702037 |
| 59 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.18722985 |
| 60 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.18244672 |
| 61 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.17119215 |
| 62 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.16736814 |
| 63 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.13970865 |
| 64 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.13157513 |
| 65 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.12902714 |
| 66 | P300_19829295_ChIP-Seq_ESCs_Human | 1.12380401 |
| 67 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.09098654 |
| 68 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.08573305 |
| 69 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.08296733 |
| 70 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.07577761 |
| 71 | GATA3_26560356_Chip-Seq_TH2_Human | 1.06523147 |
| 72 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.06329337 |
| 73 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.06014286 |
| 74 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.05365464 |
| 75 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.05015418 |
| 76 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.04379177 |
| 77 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.03605483 |
| 78 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.03017459 |
| 79 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.02083475 |
| 80 | NCOR_22424771_ChIP-Seq_293T_Human | 1.01766486 |
| 81 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.01452973 |
| 82 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.01452973 |
| 83 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.00688641 |
| 84 | TTF2_22483619_ChIP-Seq_HELA_Human | 0.99993286 |
| 85 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.98628680 |
| 86 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.97121387 |
| 87 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.96948051 |
| 88 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.92755197 |
| 89 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.92646789 |
| 90 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.92368743 |
| 91 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92149141 |
| 92 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.91997160 |
| 93 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.91885696 |
| 94 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.88660159 |
| 95 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.88628827 |
| 96 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.87837529 |
| 97 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.87647233 |
| 98 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.87062301 |
| 99 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.86714243 |
| 100 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.86321917 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0006292_abnormal_olfactory_placode | 5.12739235 |
| 2 | MP0005671_abnormal_response_to | 4.12802289 |
| 3 | MP0008789_abnormal_olfactory_epithelium | 3.49435853 |
| 4 | MP0002638_abnormal_pupillary_reflex | 2.79603251 |
| 5 | MP0005394_taste/olfaction_phenotype | 2.76457455 |
| 6 | MP0005499_abnormal_olfactory_system | 2.76457455 |
| 7 | MP0009785_altered_susceptibility_to | 2.73052537 |
| 8 | MP0006072_abnormal_retinal_apoptosis | 2.64779365 |
| 9 | MP0001835_abnormal_antigen_presentation | 2.57922891 |
| 10 | MP0005257_abnormal_intraocular_pressure | 2.49130832 |
| 11 | MP0002102_abnormal_ear_morphology | 2.26013779 |
| 12 | MP0002822_catalepsy | 2.13228226 |
| 13 | MP0001529_abnormal_vocalization | 2.12249315 |
| 14 | MP0001905_abnormal_dopamine_level | 2.01165500 |
| 15 | MP0000372_irregular_coat_pigmentation | 1.99465224 |
| 16 | MP0002148_abnormal_hypersensitivity_rea | 1.85485499 |
| 17 | MP0003880_abnormal_central_pattern | 1.78308401 |
| 18 | MP0004145_abnormal_muscle_electrophysio | 1.78280794 |
| 19 | MP0005084_abnormal_gallbladder_morpholo | 1.74508143 |
| 20 | MP0009333_abnormal_splenocyte_physiolog | 1.72846473 |
| 21 | MP0008877_abnormal_DNA_methylation | 1.71785845 |
| 22 | MP0005000_abnormal_immune_tolerance | 1.63423281 |
| 23 | MP0005387_immune_system_phenotype | 1.62349906 |
| 24 | MP0001790_abnormal_immune_system | 1.62349906 |
| 25 | MP0005253_abnormal_eye_physiology | 1.61844701 |
| 26 | MP0004147_increased_porphyrin_level | 1.61742842 |
| 27 | MP0002938_white_spotting | 1.61620143 |
| 28 | MP0002736_abnormal_nociception_after | 1.59382600 |
| 29 | MP0008872_abnormal_physiological_respon | 1.58044348 |
| 30 | MP0005551_abnormal_eye_electrophysiolog | 1.54290239 |
| 31 | MP0008875_abnormal_xenobiotic_pharmacok | 1.48902566 |
| 32 | MP0002653_abnormal_ependyma_morphology | 1.46973726 |
| 33 | MP0002166_altered_tumor_susceptibility | 1.46839880 |
| 34 | MP0001800_abnormal_humoral_immune | 1.46652946 |
| 35 | MP0001968_abnormal_touch/_nociception | 1.41302579 |
| 36 | MP0003786_premature_aging | 1.40787194 |
| 37 | MP0008058_abnormal_DNA_repair | 1.39866228 |
| 38 | MP0010386_abnormal_urinary_bladder | 1.39795228 |
| 39 | MP0003195_calcinosis | 1.38064948 |
| 40 | MP0005645_abnormal_hypothalamus_physiol | 1.34947930 |
| 41 | MP0002723_abnormal_immune_serum | 1.34745506 |
| 42 | MP0002277_abnormal_respiratory_mucosa | 1.34327141 |
| 43 | MP0003866_abnormal_defecation | 1.29284101 |
| 44 | MP0002933_joint_inflammation | 1.27884880 |
| 45 | MP0003763_abnormal_thymus_physiology | 1.24441551 |
| 46 | MP0002006_tumorigenesis | 1.24282800 |
| 47 | MP0001919_abnormal_reproductive_system | 1.23319494 |
| 48 | MP0002420_abnormal_adaptive_immunity | 1.23024262 |
| 49 | MP0001819_abnormal_immune_cell | 1.19827559 |
| 50 | MP0000613_abnormal_salivary_gland | 1.19472999 |
| 51 | MP0002234_abnormal_pharynx_morphology | 1.17479907 |
| 52 | MP0002837_dystrophic_cardiac_calcinosis | 1.15204157 |
| 53 | MP0010155_abnormal_intestine_physiology | 1.13910427 |
| 54 | MP0005025_abnormal_response_to | 1.13543698 |
| 55 | MP0000538_abnormal_urinary_bladder | 1.11143430 |
| 56 | MP0001984_abnormal_olfaction | 1.10203361 |
| 57 | MP0006036_abnormal_mitochondrial_physio | 1.10000134 |
| 58 | MP0002452_abnormal_antigen_presenting | 1.01284758 |
| 59 | MP0004885_abnormal_endolymph | 1.00634767 |
| 60 | MP0002751_abnormal_autonomic_nervous | 0.98344530 |
| 61 | MP0005075_abnormal_melanosome_morpholog | 0.96395863 |
| 62 | MP0005389_reproductive_system_phenotype | 0.94693521 |
| 63 | MP0004133_heterotaxia | 0.93908393 |
| 64 | MP0005360_urolithiasis | 0.93146689 |
| 65 | MP0000689_abnormal_spleen_morphology | 0.90613933 |
| 66 | MP0002722_abnormal_immune_system | 0.90104051 |
| 67 | MP0002160_abnormal_reproductive_system | 0.89478681 |
| 68 | MP0008995_early_reproductive_senescence | 0.88535704 |
| 69 | MP0001845_abnormal_inflammatory_respons | 0.87913743 |
| 70 | MP0004142_abnormal_muscle_tone | 0.87015175 |
| 71 | MP0000716_abnormal_immune_system | 0.85856480 |
| 72 | MP0003724_increased_susceptibility_to | 0.85617629 |
| 73 | MP0002282_abnormal_trachea_morphology | 0.85408832 |
| 74 | MP0000049_abnormal_middle_ear | 0.84412801 |
| 75 | MP0005410_abnormal_fertilization | 0.81636116 |
| 76 | MP0002876_abnormal_thyroid_physiology | 0.80109669 |
| 77 | MP0002272_abnormal_nervous_system | 0.78575926 |
| 78 | MP0003045_fibrosis | 0.78229133 |
| 79 | MP0000703_abnormal_thymus_morphology | 0.75962267 |
| 80 | MP0003137_abnormal_impulse_conducting | 0.73443209 |
| 81 | MP0002398_abnormal_bone_marrow | 0.73412444 |
| 82 | MP0003878_abnormal_ear_physiology | 0.72995980 |
| 83 | MP0005377_hearing/vestibular/ear_phenot | 0.72995980 |
| 84 | MP0009046_muscle_twitch | 0.72568957 |
| 85 | MP0002405_respiratory_system_inflammati | 0.72474940 |
| 86 | MP0005391_vision/eye_phenotype | 0.72143546 |
| 87 | MP0003011_delayed_dark_adaptation | 0.70640565 |
| 88 | MP0006276_abnormal_autonomic_nervous | 0.69930266 |
| 89 | MP0003938_abnormal_ear_development | 0.69587477 |
| 90 | MP0000685_abnormal_immune_system | 0.68089922 |
| 91 | MP0005386_behavior/neurological_phenoty | 0.67288738 |
| 92 | MP0004924_abnormal_behavior | 0.67288738 |
| 93 | MP0005379_endocrine/exocrine_gland_phen | 0.66552050 |
| 94 | MP0009764_decreased_sensitivity_to | 0.66150318 |
| 95 | MP0000647_abnormal_sebaceous_gland | 0.64974917 |
| 96 | MP0001873_stomach_inflammation | 0.64475142 |
| 97 | MP0002693_abnormal_pancreas_physiology | 0.63949202 |
| 98 | MP0001293_anophthalmia | 0.62876723 |
| 99 | MP0002138_abnormal_hepatobiliary_system | 0.62781957 |
| 100 | MP0002429_abnormal_blood_cell | 0.62614571 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Severe combined immunodeficiency (HP:0004430) | 4.33744087 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 4.01452576 |
| 3 | IgG deficiency (HP:0004315) | 3.91227025 |
| 4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.89049230 |
| 5 | Mitochondrial inheritance (HP:0001427) | 3.79104067 |
| 6 | Generalized aminoaciduria (HP:0002909) | 3.70151728 |
| 7 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 3.67867562 |
| 8 | Hypoplasia of the fovea (HP:0007750) | 3.67867562 |
| 9 | T lymphocytopenia (HP:0005403) | 3.67055974 |
| 10 | Hypoproteinemia (HP:0003075) | 3.62169196 |
| 11 | Thyroiditis (HP:0100646) | 3.54071810 |
| 12 | Increased CSF lactate (HP:0002490) | 3.51938077 |
| 13 | Aplastic anemia (HP:0001915) | 3.50907930 |
| 14 | Hepatic necrosis (HP:0002605) | 3.50617791 |
| 15 | Renal cortical cysts (HP:0000803) | 3.48485972 |
| 16 | Hepatocellular necrosis (HP:0001404) | 3.45004468 |
| 17 | Combined immunodeficiency (HP:0005387) | 3.37830527 |
| 18 | Abnormality of the fovea (HP:0000493) | 3.32156783 |
| 19 | 3-Methylglutaconic aciduria (HP:0003535) | 3.28129205 |
| 20 | Progressive macrocephaly (HP:0004481) | 3.26474456 |
| 21 | Acute encephalopathy (HP:0006846) | 3.21713299 |
| 22 | Increased hepatocellular lipid droplets (HP:0006565) | 3.18040848 |
| 23 | Abnormality of T cell number (HP:0011839) | 3.15054900 |
| 24 | Lipid accumulation in hepatocytes (HP:0006561) | 3.09954210 |
| 25 | Abolished electroretinogram (ERG) (HP:0000550) | 3.09781251 |
| 26 | Increased intramyocellular lipid droplets (HP:0012240) | 2.99479788 |
| 27 | Abnormality of eosinophils (HP:0001879) | 2.88369096 |
| 28 | Renal Fanconi syndrome (HP:0001994) | 2.87725786 |
| 29 | Cerebral edema (HP:0002181) | 2.87725418 |
| 30 | Congenital stationary night blindness (HP:0007642) | 2.87543662 |
| 31 | B lymphocytopenia (HP:0010976) | 2.80669533 |
| 32 | Stomatitis (HP:0010280) | 2.74475386 |
| 33 | Type I transferrin isoform profile (HP:0003642) | 2.70731599 |
| 34 | Increased serum lactate (HP:0002151) | 2.62151162 |
| 35 | Abnormality of the renal cortex (HP:0011035) | 2.57388375 |
| 36 | Panhypogammaglobulinemia (HP:0003139) | 2.56386487 |
| 37 | Increased muscle lipid content (HP:0009058) | 2.55340806 |
| 38 | Abnormality of B cell number (HP:0010975) | 2.54867164 |
| 39 | Abnormal protein glycosylation (HP:0012346) | 2.51695764 |
| 40 | Abnormal glycosylation (HP:0012345) | 2.51695764 |
| 41 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.51695764 |
| 42 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.51695764 |
| 43 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.51643174 |
| 44 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.51643174 |
| 45 | Pancreatic cysts (HP:0001737) | 2.51180516 |
| 46 | Lactic acidosis (HP:0003128) | 2.49122592 |
| 47 | Abnormality of T cells (HP:0002843) | 2.46863838 |
| 48 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.45637338 |
| 49 | Optic disc pallor (HP:0000543) | 2.38578828 |
| 50 | Hypothermia (HP:0002045) | 2.36451974 |
| 51 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.36243706 |
| 52 | Oral leukoplakia (HP:0002745) | 2.35150322 |
| 53 | Increased IgM level (HP:0003496) | 2.31695533 |
| 54 | IgM deficiency (HP:0002850) | 2.31188613 |
| 55 | Eosinophilia (HP:0001880) | 2.29494557 |
| 56 | Abnormality of midbrain morphology (HP:0002418) | 2.28218077 |
| 57 | Molar tooth sign on MRI (HP:0002419) | 2.28218077 |
| 58 | Optic nerve hypoplasia (HP:0000609) | 2.21757940 |
| 59 | Reduced antithrombin III activity (HP:0001976) | 2.20868748 |
| 60 | Exertional dyspnea (HP:0002875) | 2.19099170 |
| 61 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.18827618 |
| 62 | Abnormality of the prostate (HP:0008775) | 2.18559988 |
| 63 | Exercise-induced muscle cramps (HP:0003710) | 2.14012124 |
| 64 | Exercise intolerance (HP:0003546) | 2.12181284 |
| 65 | True hermaphroditism (HP:0010459) | 2.06463272 |
| 66 | Respiratory failure (HP:0002878) | 2.05368138 |
| 67 | Aplasia/Hypoplasia of the macula (HP:0008059) | 2.03606947 |
| 68 | Hypoplasia of the thymus (HP:0000778) | 2.02958009 |
| 69 | Abnormality of alanine metabolism (HP:0010916) | 1.99147925 |
| 70 | Hyperalaninemia (HP:0003348) | 1.99147925 |
| 71 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.99147925 |
| 72 | Abnormality of urine glucose concentration (HP:0011016) | 1.98510192 |
| 73 | Glycosuria (HP:0003076) | 1.98510192 |
| 74 | Nephronophthisis (HP:0000090) | 1.97412077 |
| 75 | Tongue fasciculations (HP:0001308) | 1.95573018 |
| 76 | Methylmalonic acidemia (HP:0002912) | 1.95253003 |
| 77 | Aplasia/Hypoplasia affecting the retina (HP:0008061) | 1.93535827 |
| 78 | Medial flaring of the eyebrow (HP:0010747) | 1.93053356 |
| 79 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.89245862 |
| 80 | Pancytopenia (HP:0001876) | 1.88243674 |
| 81 | Attenuation of retinal blood vessels (HP:0007843) | 1.87110153 |
| 82 | Cellular immunodeficiency (HP:0005374) | 1.86533049 |
| 83 | Lethargy (HP:0001254) | 1.85333678 |
| 84 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.84444335 |
| 85 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.83401300 |
| 86 | Dicarboxylic aciduria (HP:0003215) | 1.83401300 |
| 87 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.81689655 |
| 88 | Pancreatic fibrosis (HP:0100732) | 1.78891860 |
| 89 | Septo-optic dysplasia (HP:0100842) | 1.77796333 |
| 90 | Abnormality of renal resorption (HP:0011038) | 1.77364851 |
| 91 | Encephalitis (HP:0002383) | 1.76809085 |
| 92 | Parakeratosis (HP:0001036) | 1.75160525 |
| 93 | Pendular nystagmus (HP:0012043) | 1.75106627 |
| 94 | Abnormality of the renal medulla (HP:0100957) | 1.73579110 |
| 95 | Abnormality of macular pigmentation (HP:0008002) | 1.72978655 |
| 96 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.72393610 |
| 97 | CNS hypomyelination (HP:0003429) | 1.71849325 |
| 98 | Leukocytosis (HP:0001974) | 1.71784743 |
| 99 | Hyperglycinuria (HP:0003108) | 1.68496846 |
| 100 | Fibular aplasia (HP:0002990) | 1.67899790 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 3.56247493 |
| 2 | BCKDK | 3.44197150 |
| 3 | TESK2 | 3.42316792 |
| 4 | VRK2 | 3.12975601 |
| 5 | BUB1 | 3.03892870 |
| 6 | KDR | 2.75203405 |
| 7 | TLK1 | 2.65635107 |
| 8 | STK16 | 2.54178314 |
| 9 | TAOK3 | 2.43326574 |
| 10 | MAP4K2 | 2.39207862 |
| 11 | ZAK | 2.07896619 |
| 12 | NUAK1 | 2.00919124 |
| 13 | ADRBK2 | 1.89867315 |
| 14 | MAP3K12 | 1.88183505 |
| 15 | MAPK13 | 1.86476933 |
| 16 | MAP4K1 | 1.75678348 |
| 17 | SRPK1 | 1.73543762 |
| 18 | WNK3 | 1.72697813 |
| 19 | VRK1 | 1.70935936 |
| 20 | TESK1 | 1.70081934 |
| 21 | LIMK1 | 1.68095393 |
| 22 | ITK | 1.61646153 |
| 23 | NME1 | 1.48757753 |
| 24 | CDK19 | 1.45544683 |
| 25 | GRK1 | 1.42534444 |
| 26 | WNK4 | 1.40806015 |
| 27 | TIE1 | 1.30207241 |
| 28 | FES | 1.27889597 |
| 29 | PHKG1 | 1.21196814 |
| 30 | PHKG2 | 1.21196814 |
| 31 | DAPK1 | 1.20070600 |
| 32 | CSNK1G3 | 1.17663986 |
| 33 | PTK2B | 1.15299142 |
| 34 | TEC | 1.12201519 |
| 35 | EIF2AK3 | 1.08279162 |
| 36 | GRK6 | 1.08174157 |
| 37 | MAPKAPK3 | 1.04556999 |
| 38 | TRIM28 | 1.04036596 |
| 39 | MST4 | 1.01923589 |
| 40 | BMPR1B | 0.98020069 |
| 41 | PINK1 | 0.97727369 |
| 42 | DYRK2 | 0.94912396 |
| 43 | CSNK1G2 | 0.94443913 |
| 44 | CSNK1G1 | 0.92054451 |
| 45 | FRK | 0.86408732 |
| 46 | PRKCQ | 0.83950522 |
| 47 | CSNK1A1L | 0.83497638 |
| 48 | ERBB3 | 0.82209806 |
| 49 | SYK | 0.78124839 |
| 50 | MAP2K7 | 0.76066251 |
| 51 | OXSR1 | 0.75634222 |
| 52 | FLT3 | 0.71906595 |
| 53 | CCNB1 | 0.70183471 |
| 54 | PLK2 | 0.68349949 |
| 55 | KIT | 0.67267271 |
| 56 | IKBKB | 0.67131037 |
| 57 | IKBKE | 0.67122974 |
| 58 | RPS6KA5 | 0.67017627 |
| 59 | INSRR | 0.66905377 |
| 60 | MUSK | 0.64594486 |
| 61 | EIF2AK2 | 0.64227842 |
| 62 | PLK3 | 0.64161345 |
| 63 | LCK | 0.63738577 |
| 64 | TBK1 | 0.62734753 |
| 65 | MYLK | 0.59451430 |
| 66 | HIPK2 | 0.59232639 |
| 67 | LMTK2 | 0.57641620 |
| 68 | MAP2K6 | 0.54833849 |
| 69 | TSSK6 | 0.53697791 |
| 70 | MAPKAPK5 | 0.48786703 |
| 71 | OBSCN | 0.48241435 |
| 72 | JAK3 | 0.48200933 |
| 73 | LYN | 0.45426463 |
| 74 | CSK | 0.45347551 |
| 75 | MATK | 0.44324865 |
| 76 | CAMKK2 | 0.43977333 |
| 77 | AURKA | 0.43728831 |
| 78 | MAP3K11 | 0.43375029 |
| 79 | FER | 0.42572432 |
| 80 | BCR | 0.41697047 |
| 81 | ILK | 0.41112731 |
| 82 | PIK3CG | 0.40956573 |
| 83 | CSNK1A1 | 0.40474622 |
| 84 | GRK7 | 0.37984974 |
| 85 | CSNK2A1 | 0.37878352 |
| 86 | MKNK1 | 0.37538982 |
| 87 | PRKCE | 0.36510998 |
| 88 | CDK8 | 0.35364972 |
| 89 | MAP2K2 | 0.34898906 |
| 90 | CSF1R | 0.33988889 |
| 91 | STK38L | 0.33553891 |
| 92 | IGF1R | 0.32821855 |
| 93 | BTK | 0.32363223 |
| 94 | GRK5 | 0.27456590 |
| 95 | PLK4 | 0.27319969 |
| 96 | PAK1 | 0.25990319 |
| 97 | CAMK2A | 0.25961460 |
| 98 | PRKACA | 0.25018806 |
| 99 | EIF2AK1 | 0.24917969 |
| 100 | NEK1 | 0.24821428 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.37569786 |
| 2 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.66869254 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.57117841 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.20681771 |
| 5 | Protein export_Homo sapiens_hsa03060 | 2.82484028 |
| 6 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.00419906 |
| 7 | Allograft rejection_Homo sapiens_hsa05330 | 1.99788008 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 1.95686218 |
| 9 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.90922915 |
| 10 | Alzheimers disease_Homo sapiens_hsa05010 | 1.89170638 |
| 11 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.85772362 |
| 12 | Ribosome_Homo sapiens_hsa03010 | 1.82664516 |
| 13 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.82653378 |
| 14 | Phototransduction_Homo sapiens_hsa04744 | 1.81485558 |
| 15 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.79988971 |
| 16 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.79902450 |
| 17 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.75521442 |
| 18 | Huntingtons disease_Homo sapiens_hsa05016 | 1.73177888 |
| 19 | Mismatch repair_Homo sapiens_hsa03430 | 1.70790199 |
| 20 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.58906095 |
| 21 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.49855689 |
| 22 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.41129395 |
| 23 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.40872389 |
| 24 | DNA replication_Homo sapiens_hsa03030 | 1.38300248 |
| 25 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.36679526 |
| 26 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.35963155 |
| 27 | Asthma_Homo sapiens_hsa05310 | 1.31442252 |
| 28 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.29339174 |
| 29 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.25531876 |
| 30 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.25452004 |
| 31 | RNA degradation_Homo sapiens_hsa03018 | 1.19279463 |
| 32 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.18916228 |
| 33 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.17938696 |
| 34 | Homologous recombination_Homo sapiens_hsa03440 | 1.14339426 |
| 35 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.13950586 |
| 36 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.10226184 |
| 37 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.07656293 |
| 38 | Spliceosome_Homo sapiens_hsa03040 | 1.06725557 |
| 39 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.05004739 |
| 40 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.04144503 |
| 41 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.03141240 |
| 42 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.03137379 |
| 43 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.00110228 |
| 44 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.99378151 |
| 45 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.99095036 |
| 46 | Basal transcription factors_Homo sapiens_hsa03022 | 0.95219685 |
| 47 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.93851595 |
| 48 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.92080297 |
| 49 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.90780890 |
| 50 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.90444354 |
| 51 | Purine metabolism_Homo sapiens_hsa00230 | 0.90079963 |
| 52 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.89956327 |
| 53 | Base excision repair_Homo sapiens_hsa03410 | 0.85038603 |
| 54 | Peroxisome_Homo sapiens_hsa04146 | 0.83839729 |
| 55 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.77746611 |
| 56 | RNA transport_Homo sapiens_hsa03013 | 0.75749027 |
| 57 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.72497345 |
| 58 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.72166027 |
| 59 | Measles_Homo sapiens_hsa05162 | 0.70037105 |
| 60 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.68761933 |
| 61 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.68198691 |
| 62 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.68120862 |
| 63 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.66467254 |
| 64 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.64299993 |
| 65 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.63475006 |
| 66 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.63417007 |
| 67 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.62522156 |
| 68 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.61529903 |
| 69 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.60632917 |
| 70 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.58450099 |
| 71 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.57116787 |
| 72 | Viral myocarditis_Homo sapiens_hsa05416 | 0.55031619 |
| 73 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.54133693 |
| 74 | Carbon metabolism_Homo sapiens_hsa01200 | 0.53762367 |
| 75 | Metabolic pathways_Homo sapiens_hsa01100 | 0.51252209 |
| 76 | Legionellosis_Homo sapiens_hsa05134 | 0.50455840 |
| 77 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.50117103 |
| 78 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.49432416 |
| 79 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.48968478 |
| 80 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.48932665 |
| 81 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.48635877 |
| 82 | Alcoholism_Homo sapiens_hsa05034 | 0.46307037 |
| 83 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.45838819 |
| 84 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.45320216 |
| 85 | Shigellosis_Homo sapiens_hsa05131 | 0.43871539 |
| 86 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.43689209 |
| 87 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.42800997 |
| 88 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.42749815 |
| 89 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.42309665 |
| 90 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.42190506 |
| 91 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.40780370 |
| 92 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.39721644 |
| 93 | Retinol metabolism_Homo sapiens_hsa00830 | 0.39022389 |
| 94 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.38999534 |
| 95 | Sulfur relay system_Homo sapiens_hsa04122 | 0.38470057 |
| 96 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.38090739 |
| 97 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.37906900 |
| 98 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.37537296 |
| 99 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.34425842 |
| 100 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.31459976 |

