PGK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed specifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functional phosphoglycerate kinase that catalyzes the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of spermatogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.75933385
2spermatid development (GO:0007286)9.75845859
3motile cilium assembly (GO:0044458)9.25194596
4regulation of cilium movement (GO:0003352)8.72288562
5cilium movement (GO:0003341)8.44396639
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.88030863
7single fertilization (GO:0007338)7.74873042
8rRNA methylation (GO:0031167)7.68306617
9piRNA metabolic process (GO:0034587)7.68028833
10male meiosis (GO:0007140)7.56770297
11protein targeting to Golgi (GO:0000042)7.55640776
12sperm capacitation (GO:0048240)7.50573305
13phosphatidylethanolamine biosynthetic process (GO:0006646)7.32512228
14synaptonemal complex organization (GO:0070193)7.29351529
15establishment of protein localization to Golgi (GO:0072600)7.26659810
16synaptonemal complex assembly (GO:0007130)7.09634387
17retrograde transport, vesicle recycling within Golgi (GO:0000301)7.03239428
18negative regulation of inclusion body assembly (GO:0090084)6.83924469
19phosphatidylethanolamine metabolic process (GO:0046337)6.80844851
20response to pheromone (GO:0019236)6.63343847
21spermatogenesis (GO:0007283)6.51727517
22fertilization (GO:0009566)6.50827202
23rRNA modification (GO:0000154)6.49684182
24male gamete generation (GO:0048232)6.49370043
25microtubule depolymerization (GO:0007019)6.27018659
26organic cation transport (GO:0015695)6.21238756
27gamete generation (GO:0007276)5.96883490
28centriole replication (GO:0007099)5.82497006
29regulation of inclusion body assembly (GO:0090083)5.68102522
30protein localization to Golgi apparatus (GO:0034067)5.45002103
31germ cell development (GO:0007281)5.43762434
32ventricular system development (GO:0021591)5.41330457
33cellular process involved in reproduction in multicellular organism (GO:0022412)5.41030051
34calcium ion-dependent exocytosis (GO:0017156)5.38821934
35RNA destabilization (GO:0050779)5.27434408
36regulation of microtubule-based movement (GO:0060632)5.19403153
37cellular ketone body metabolic process (GO:0046950)5.13897858
38cell recognition (GO:0008037)5.05249422
39male meiosis I (GO:0007141)5.04859776
40spermatid nucleus differentiation (GO:0007289)5.02468420
41chromosome organization involved in meiosis (GO:0070192)4.89991150
42DNA methylation involved in gamete generation (GO:0043046)4.85576737
43glycerol ether metabolic process (GO:0006662)4.83795919
44multicellular organismal reproductive process (GO:0048609)4.71790944
45positive regulation of Rab GTPase activity (GO:0032851)4.67758870
46regulation of Rab GTPase activity (GO:0032313)4.67758870
47microtubule severing (GO:0051013)4.66092389
48seminiferous tubule development (GO:0072520)4.60257646
49regulation of transcription involved in cell fate commitment (GO:0060850)4.54970064
50ketone body metabolic process (GO:1902224)4.52560098
51ether metabolic process (GO:0018904)4.47167617
52chromosome condensation (GO:0030261)4.42663604
53meiotic nuclear division (GO:0007126)4.42125194
54left/right pattern formation (GO:0060972)4.25307920
55DNA packaging (GO:0006323)4.19711841
56chromatin silencing (GO:0006342)4.15122667
57meiosis I (GO:0007127)4.03563144
58multicellular organismal movement (GO:0050879)4.00258488
59musculoskeletal movement (GO:0050881)4.00258488
60chaperone-mediated protein complex assembly (GO:0051131)3.95965935
61sexual reproduction (GO:0019953)3.94797014
62polyamine biosynthetic process (GO:0006596)3.92095630
63genitalia morphogenesis (GO:0035112)3.85009148
64single strand break repair (GO:0000012)3.84313031
65monoubiquitinated protein deubiquitination (GO:0035520)3.80867068
66multicellular organismal development (GO:0007275)3.79519075
67membrane protein intracellular domain proteolysis (GO:0031293)3.76737533
68microtubule nucleation (GO:0007020)3.63730419
69glomerular visceral epithelial cell development (GO:0072015)3.61737652
70protein polyglutamylation (GO:0018095)3.60748017
71nucleosome disassembly (GO:0006337)3.59119690
72protein-DNA complex disassembly (GO:0032986)3.59119690
73response to acidic pH (GO:0010447)3.55903973
74meiotic cell cycle (GO:0051321)3.52274821
75glomerular epithelial cell development (GO:0072310)3.45258235
76protein localization to cilium (GO:0061512)3.37699537
77cellular response to pH (GO:0071467)3.37423859
78protein K11-linked deubiquitination (GO:0035871)3.34124339
79peptidyl-threonine dephosphorylation (GO:0035970)3.33084752
80homeostasis of number of cells within a tissue (GO:0048873)3.28823454
81protein refolding (GO:0042026)3.28426229
82microtubule polymerization or depolymerization (GO:0031109)3.21103768
83coenzyme catabolic process (GO:0009109)3.13645990
84regulation of spindle checkpoint (GO:0090231)3.12800588
85amino-acid betaine transport (GO:0015838)3.12721897
86carnitine transport (GO:0015879)3.12721897
87regulation of interleukin-13 production (GO:0032656)3.10869151
88cerebral cortex neuron differentiation (GO:0021895)3.09032809
89negative regulation of Rho protein signal transduction (GO:0035024)3.09021348
90regulation of phosphoprotein phosphatase activity (GO:0043666)3.08308401
91polyol catabolic process (GO:0046174)3.07973186
92nucleoside diphosphate phosphorylation (GO:0006165)3.05290696
93alditol metabolic process (GO:0019400)3.04970767
94nucleus organization (GO:0006997)3.02045387
95protein depolymerization (GO:0051261)3.01159425
96positive regulation of guanylate cyclase activity (GO:0031284)2.98295753
97mitochondrial fission (GO:0000266)2.97551540
98carnitine transmembrane transport (GO:1902603)2.97423841
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.97243291
100lactate metabolic process (GO:0006089)2.95786988
101microtubule-based movement (GO:0007018)2.95289970
102intraciliary transport (GO:0042073)2.94492404
103cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.94370553
104receptor recycling (GO:0001881)2.93776592
105cilium organization (GO:0044782)2.93282962
106mitotic sister chromatid cohesion (GO:0007064)2.92450385
107synapsis (GO:0007129)2.92344557
108sequestering of actin monomers (GO:0042989)2.89621157
109meiotic cell cycle process (GO:1903046)2.86641222
110negative regulation of gene expression, epigenetic (GO:0045814)2.86266955
111GTP biosynthetic process (GO:0006183)2.84433914
112histone H3-K9 demethylation (GO:0033169)2.83871240
113centrosome duplication (GO:0051298)2.83549241
114gene silencing by RNA (GO:0031047)2.82974760
115negative regulation of organelle assembly (GO:1902116)2.82858638
116intra-Golgi vesicle-mediated transport (GO:0006891)2.81463676
117regulation of guanylate cyclase activity (GO:0031282)2.81406001
118cilium assembly (GO:0042384)2.80699711
119Golgi to endosome transport (GO:0006895)2.78758035
120DNA conformation change (GO:0071103)2.78673993
121regulation of T-helper 2 cell differentiation (GO:0045628)2.78200013
122cellular component assembly involved in morphogenesis (GO:0010927)2.75509371
123axoneme assembly (GO:0035082)2.74195624
124cilium morphogenesis (GO:0060271)2.67108499
125centriole assembly (GO:0098534)2.58951701
126interferon-gamma secretion (GO:0072643)2.57504075
127glycerol metabolic process (GO:0006071)2.56538107
128UTP biosynthetic process (GO:0006228)2.55397222
129regulation of cilium assembly (GO:1902017)2.52247602
130peptidyl-glutamic acid modification (GO:0018200)2.51506884
131nuclear pore complex assembly (GO:0051292)2.50708137
132positive regulation of macrophage activation (GO:0043032)2.48484597
133regulation of centriole replication (GO:0046599)2.47945310
134RNA localization (GO:0006403)2.47595824
135* glycolytic process (GO:0006096)2.47324327
136fusion of sperm to egg plasma membrane (GO:0007342)14.2086718
137* sperm motility (GO:0030317)13.6852659
138cell wall macromolecule metabolic process (GO:0044036)12.2547464
139cell wall macromolecule catabolic process (GO:0016998)12.2547464
140acrosome reaction (GO:0007340)11.6945150
141sperm-egg recognition (GO:0035036)11.6794444
142acrosome assembly (GO:0001675)11.6507308
143multicellular organism reproduction (GO:0032504)11.4197234
144cilium or flagellum-dependent cell motility (GO:0001539)10.9731336
145plasma membrane fusion (GO:0045026)10.8291963
146binding of sperm to zona pellucida (GO:0007339)10.6252095
147cell-cell recognition (GO:0009988)10.4591860
148epithelial cilium movement (GO:0003351)10.2209456
149axonemal dynein complex assembly (GO:0070286)10.1866345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.63662716
2EZH2_22144423_ChIP-Seq_EOC_Human4.43644493
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.41467351
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.24988152
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.21841796
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.44665918
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.28950242
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.25805649
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.99101247
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.73865454
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.46341060
12VDR_22108803_ChIP-Seq_LS180_Human2.41684893
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.35319181
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.26759791
15CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.19501184
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.17150319
17VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.13048395
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12162054
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.06123435
20ZNF274_21170338_ChIP-Seq_K562_Hela2.04614650
21FUS_26573619_Chip-Seq_HEK293_Human2.01430336
22GATA1_26923725_Chip-Seq_HPCs_Mouse1.96056072
23ELF1_20517297_ChIP-Seq_JURKAT_Human1.88738227
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87328286
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86802629
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85978083
27RAC3_21632823_ChIP-Seq_H3396_Human1.83433962
28DROSHA_22980978_ChIP-Seq_HELA_Human1.82718717
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.81151574
30ERA_21632823_ChIP-Seq_H3396_Human1.80046515
31NANOG_20526341_ChIP-Seq_ESCs_Human1.75958871
32TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.74644487
33EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.73588055
34CTCF_27219007_Chip-Seq_Bcells_Human1.72726944
35ELK4_26923725_Chip-Seq_MESODERM_Mouse1.71770491
36RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.67971761
37RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.67514675
38* STAT1_17558387_ChIP-Seq_HELA_Human1.65779818
39FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63466245
40MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.60893772
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60425388
42GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.57496951
43ARNT_22903824_ChIP-Seq_MCF-7_Human1.56265278
44WDR5_24793694_ChIP-Seq_LNCAP_Human1.56099103
45BCL6_27268052_Chip-Seq_Bcells_Human1.55506442
46SOX2_22085726_ChIP-Seq_NPCs_Mouse1.54020479
47MYC_19829295_ChIP-Seq_ESCs_Human1.53324666
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.52940636
49TDRD3_21172665_ChIP-Seq_MCF-7_Human1.52898278
50KAP1_22055183_ChIP-Seq_ESCs_Mouse1.52572937
51ER_23166858_ChIP-Seq_MCF-7_Human1.52234544
52TAL1_26923725_Chip-Seq_HPCs_Mouse1.49141860
53OCT4_20526341_ChIP-Seq_ESCs_Human1.48392823
54CBP_20019798_ChIP-Seq_JUKART_Human1.48392585
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48392585
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.47405532
57* TAF2_19829295_ChIP-Seq_ESCs_Human1.47223396
58RBPJ_21746931_ChIP-Seq_IB4_Human1.47143438
59* KDM2B_26808549_Chip-Seq_REH_Human1.46442286
60BCOR_27268052_Chip-Seq_Bcells_Human1.45581314
61GATA3_21867929_ChIP-Seq_CD8_Mouse1.45145711
62CBX2_22325352_ChIP-Seq_293T-Rex_Human1.44832888
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.44561196
64SMC4_20622854_ChIP-Seq_HELA_Human1.44075492
65HNFA_21074721_ChIP-Seq_CACO-2_Human1.40977618
66CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.40913235
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40593068
68PHF8_20622854_ChIP-Seq_HELA_Human1.40170662
69CTCF_20526341_ChIP-Seq_ESCs_Human1.40129347
70E2F1_20622854_ChIP-Seq_HELA_Human1.39245788
71P68_20966046_ChIP-Seq_HELA_Human1.38915463
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37548352
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.37257551
74ETV1_20927104_ChIP-Seq_GIST48_Human1.37236826
75TP63_22573176_ChIP-Seq_HFKS_Human1.35117769
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.33916736
77* AR_25329375_ChIP-Seq_VCAP_Human1.33381215
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32082821
79P300_27268052_Chip-Seq_Bcells_Human1.31355228
80SMAD3_21741376_ChIP-Seq_ESCs_Human1.31249446
81TP53_18474530_ChIP-ChIP_U2OS_Human1.30146247
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29937090
83LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.29500414
84GATA3_21867929_ChIP-Seq_TH1_Mouse1.29337953
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28812007
86ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28698372
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28291820
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27663496
89P300_19829295_ChIP-Seq_ESCs_Human1.27509564
90P53_21459846_ChIP-Seq_SAOS-2_Human1.27350742
91REST_21632747_ChIP-Seq_MESCs_Mouse1.27094862
92FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.26558392
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.26210745
94P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.25493003
95CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24160053
96CEBPB_22108803_ChIP-Seq_LS180_Human1.23043917
97TAF15_26573619_Chip-Seq_HEK293_Human1.22773924
98TBL1_22424771_ChIP-Seq_293T_Human1.21335371
99SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20414411
100LXR_22292898_ChIP-Seq_THP-1_Human1.19910445
101PHF8_20622853_ChIP-Seq_HELA_Human1.18895722
102SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17853416
103CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17419511
104SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17367929
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17043075
106GF1_26923725_Chip-Seq_HPCs_Mouse1.16966793
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16810548
108GATA6_21074721_ChIP-Seq_CACO-2_Human1.16683167
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16100461
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16100461
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15921035
112GATA3_21878914_ChIP-Seq_MCF-7_Human1.15502035
113SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14702038
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13725217
115CRX_20693478_ChIP-Seq_RETINA_Mouse1.13669943
116TP63_19390658_ChIP-ChIP_HaCaT_Human1.13469767
117NANOG_18555785_Chip-Seq_ESCs_Mouse1.12841046
118RAD21_21589869_ChIP-Seq_MESCs_Mouse1.12782691
119SMAD4_21799915_ChIP-Seq_A2780_Human1.11448723
120PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10426803
121ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08733798
122SMAD4_21741376_ChIP-Seq_HESCs_Human1.08638461
123NANOG_19829295_ChIP-Seq_ESCs_Human1.08585727
124SOX2_19829295_ChIP-Seq_ESCs_Human1.08585727
125CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08530271
126NFYA_21822215_ChIP-Seq_K562_Human1.08389139
127PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.06743379
128GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.06589343
129KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06539190
130SMRT_27268052_Chip-Seq_Bcells_Human1.06464398
131RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06234806
132RUNX_20019798_ChIP-Seq_JUKART_Human1.06099507
133SPI1_26923725_Chip-Seq_HPCs_Mouse1.06046785
134CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05909469
135OCT4_18555785_Chip-Seq_ESCs_Mouse1.05502138
136RUNX2_22187159_ChIP-Seq_PCA_Human1.04496651
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03909352
138* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02942180
139P53_22387025_ChIP-Seq_ESCs_Mouse1.02231654
140RNF2_27304074_Chip-Seq_NSC_Mouse1.02041905
141EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01666003
142EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01570496
143SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01289929
144* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.01049601
145MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00829565
146SA1_27219007_Chip-Seq_Bcells_Human1.00757420
147PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00546153
148ESET_19884257_ChIP-Seq_ESCs_Mouse1.00360080
149STAT3_23295773_ChIP-Seq_U87_Human1.00205532
150DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00192518
151NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99663834
152EZH2_27294783_Chip-Seq_ESCs_Mouse0.99340318
153CMYC_18555785_Chip-Seq_ESCs_Mouse0.98688813
154RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97468604
155MYC_27129775_Chip-Seq_CORNEA_Mouse0.96274740
156OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96220882
157P300_18555785_Chip-Seq_ESCs_Mouse0.96110542
158EZH2_27294783_Chip-Seq_NPCs_Mouse0.95577502
159KLF4_18555785_Chip-Seq_ESCs_Mouse0.94082481
160SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93485033
161NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93365153
162RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93331224
163RARA_24833708_ChIP-Seq_LIVER_Mouse0.92920358
164YY1_22570637_ChIP-Seq_MALME-3M_Human0.92762549
165* ERG_20517297_ChIP-Seq_VCAP_Human0.92614760
166ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91152698
167NFYB_21822215_ChIP-Seq_K562_Human0.90842382
168CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90650966
169SOX9_26525672_Chip-Seq_HEART_Mouse0.90020583
170EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.88608017
171GF1B_26923725_Chip-Seq_HPCs_Mouse0.87317514
172LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87238891
173* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87001854
174FLI1_21867929_ChIP-Seq_CD8_Mouse0.86901308
175SMAD4_21741376_ChIP-Seq_EPCs_Human0.86851448
176SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86548952

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive6.07056998
2MP0001929_abnormal_gametogenesis5.56133070
3MP0008877_abnormal_DNA_methylation4.34393221
4MP0002210_abnormal_sex_determination3.48765432
5* MP0002161_abnormal_fertility/fecundity3.29766460
6MP0001348_abnormal_lacrimal_gland3.03938278
7MP0001145_abnormal_male_reproductive2.95118386
8MP0005670_abnormal_white_adipose2.68011628
9MP0002653_abnormal_ependyma_morphology2.66633209
10MP0000653_abnormal_sex_gland2.55394286
11MP0003718_maternal_effect2.23161391
12MP0005410_abnormal_fertilization16.3786671
13MP0000678_abnormal_parathyroid_gland1.92139195
14MP0005623_abnormal_meninges_morphology1.78047333
15MP0001485_abnormal_pinna_reflex1.72952473
16MP0005451_abnormal_body_composition1.61561953
17MP0005423_abnormal_somatic_nervous1.59298143
18MP0002132_abnormal_respiratory_system1.59284631
19MP0005379_endocrine/exocrine_gland_phen1.57721875
20MP0002160_abnormal_reproductive_system1.54770141
21MP0005310_abnormal_salivary_gland1.49875688
22MP0002282_abnormal_trachea_morphology1.43081899
23MP0001486_abnormal_startle_reflex1.43020016
24MP0002822_catalepsy1.35754883
25MP0002138_abnormal_hepatobiliary_system1.34259884
26MP0003646_muscle_fatigue1.28674971
27MP0001765_abnormal_ion_homeostasis1.23646196
28MP0004233_abnormal_muscle_weight1.22953263
29MP0009053_abnormal_anal_canal1.22664249
30MP0002249_abnormal_larynx_morphology1.18490768
31MP0004859_abnormal_synaptic_plasticity1.17758232
32MP0001963_abnormal_hearing_physiology1.08592925
33MP0002735_abnormal_chemical_nociception1.06976777
34MP0005647_abnormal_sex_gland1.03627005
35MP0008058_abnormal_DNA_repair0.99719913
36MP0002127_abnormal_cardiovascular_syste0.99573890
37MP0005395_other_phenotype0.98654583
38MP0008995_early_reproductive_senescence0.97318731
39MP0001984_abnormal_olfaction0.96066650
40MP0009046_muscle_twitch0.95276782
41MP0000026_abnormal_inner_ear0.88480496
42MP0008569_lethality_at_weaning0.83422293
43MP0001879_abnormal_lymphatic_vessel0.81543946
44MP0005167_abnormal_blood-brain_barrier0.80865772
45MP0000955_abnormal_spinal_cord0.79919723
46MP0003878_abnormal_ear_physiology0.79918036
47MP0005377_hearing/vestibular/ear_phenot0.79918036
48MP0002067_abnormal_sensory_capabilities0.79723707
49MP0001905_abnormal_dopamine_level0.79518979
50MP0005083_abnormal_biliary_tract0.78543203
51MP0005389_reproductive_system_phenotype0.77586437
52MP0002557_abnormal_social/conspecific_i0.72284295
53MP0005636_abnormal_mineral_homeostasis0.69279893
54MP0004510_myositis0.68893346
55MP0003011_delayed_dark_adaptation0.68849477
56MP0003115_abnormal_respiratory_system0.68031786
57MP0005248_abnormal_Harderian_gland0.67570268
58MP0009697_abnormal_copulation0.66449798
59MP0004085_abnormal_heartbeat0.66034004
60MP0005367_renal/urinary_system_phenotyp0.65435656
61MP0000516_abnormal_urinary_system0.65435656
62MP0000569_abnormal_digit_pigmentation0.65303840
63MP0005084_abnormal_gallbladder_morpholo0.65126390
64MP0002234_abnormal_pharynx_morphology0.65010163
65MP0010094_abnormal_chromosome_stability0.61725795
66MP0001666_abnormal_nutrient_absorption0.60820195
67MP0005666_abnormal_adipose_tissue0.57218620
68MP0002572_abnormal_emotion/affect_behav0.56405728
69MP0000049_abnormal_middle_ear0.56041566
70MP0003077_abnormal_cell_cycle0.54796116
71MP0008057_abnormal_DNA_replication0.54572383
72MP0001324_abnormal_eye_pigmentation0.54050941
73MP0000681_abnormal_thyroid_gland0.53467699
74MP0001501_abnormal_sleep_pattern0.52864368
75MP0002733_abnormal_thermal_nociception0.52635964
76MP0001440_abnormal_grooming_behavior0.51872685
77MP0000358_abnormal_cell_content/0.51685588
78MP0009745_abnormal_behavioral_response0.51470877
79MP0004484_altered_response_of0.50347856
80MP0004036_abnormal_muscle_relaxation0.50029980
81MP0001270_distended_abdomen0.49864419
82MP0002272_abnormal_nervous_system0.49743464
83MP0002928_abnormal_bile_duct0.48829337
84MP0003699_abnormal_female_reproductive0.48508446
85MP0001764_abnormal_homeostasis0.48283775
86MP0001293_anophthalmia0.47985302
87MP0003950_abnormal_plasma_membrane0.47590620
88MP0010329_abnormal_lipoprotein_level0.47166309
89MP0003329_amyloid_beta_deposits0.46920599
90MP0001873_stomach_inflammation0.44501454
91MP0000230_abnormal_systemic_arterial0.44134059
92MP0005397_hematopoietic_system_phenotyp0.42845662
93MP0001545_abnormal_hematopoietic_system0.42845662
94MP0003786_premature_aging0.41653528
95MP0002734_abnormal_mechanical_nocicepti0.41283744
96MP0005535_abnormal_body_temperature0.40297420
97MP0005408_hypopigmentation0.40148774
98MP0005253_abnormal_eye_physiology0.39801368
99MP0002269_muscular_atrophy0.39683479
100MP0000249_abnormal_blood_vessel0.39675576
101MP0005551_abnormal_eye_electrophysiolog0.39475505
102MP0003137_abnormal_impulse_conducting0.39418457
103MP0004782_abnormal_surfactant_physiolog0.38359513
104MP0009278_abnormal_bone_marrow0.38215930
105MP0001970_abnormal_pain_threshold0.37309518
106MP0009115_abnormal_fat_cell0.37166395
107MP0002736_abnormal_nociception_after0.36679955
108MP0003936_abnormal_reproductive_system0.35310569
109MP0002971_abnormal_brown_adipose0.34512085
110MP0005595_abnormal_vascular_smooth0.34280273
111MP0004019_abnormal_vitamin_homeostasis0.33493193
112MP0003632_abnormal_nervous_system0.33149552
113MP0001119_abnormal_female_reproductive0.32639452
114MP0000003_abnormal_adipose_tissue0.32512767
115MP0004084_abnormal_cardiac_muscle0.32431767
116MP0005391_vision/eye_phenotype0.32293387
117MP0003111_abnormal_nucleus_morphology0.32170335
118MP0008007_abnormal_cellular_replicative0.31214879
119MP0000534_abnormal_ureter_morphology0.31189645
120MP0003633_abnormal_nervous_system0.29113322
121MP0006036_abnormal_mitochondrial_physio0.28688898
122MP0002139_abnormal_hepatobiliary_system0.28637250
123MP0003879_abnormal_hair_cell0.25813502
124MP0004133_heterotaxia0.25398720
125MP0001730_embryonic_growth_arrest0.24862221
126MP0000604_amyloidosis0.24233292
127MP0003942_abnormal_urinary_system0.23208296
128MP0010307_abnormal_tumor_latency0.23062517
129MP0004811_abnormal_neuron_physiology0.23062386
130MP0003631_nervous_system_phenotype0.22194677
131MP0003861_abnormal_nervous_system0.21957855
132MP0002102_abnormal_ear_morphology0.21886091
133MP0001727_abnormal_embryo_implantation0.20926614
134MP0002295_abnormal_pulmonary_circulatio0.20609513
135MP0002152_abnormal_brain_morphology0.20220099
136MP0008961_abnormal_basal_metabolism0.19732452
137MP0003948_abnormal_gas_homeostasis0.19195129
138MP0002092_abnormal_eye_morphology0.19093377
139MP0004808_abnormal_hematopoietic_stem0.18762905
140MP0002169_no_abnormal_phenotype0.18721725
141MP0002873_normal_phenotype0.18474600
142MP0001968_abnormal_touch/_nociception0.18169342
143MP0005375_adipose_tissue_phenotype0.17859494
144MP0004742_abnormal_vestibular_system0.17751875
145MP0004043_abnormal_pH_regulation0.17561609
146MP0003045_fibrosis0.16790868
147MP0000313_abnormal_cell_death0.16769220
148MP0001849_ear_inflammation0.16153182
149MP0000751_myopathy0.15302187
150MP0006035_abnormal_mitochondrial_morpho0.15201107
151MP0004270_analgesia0.15171968
152MP0002229_neurodegeneration0.14775736
153MP0004145_abnormal_muscle_electrophysio0.14288754
154MP0005365_abnormal_bile_salt0.14232134
155MP0008875_abnormal_xenobiotic_pharmacok0.13938825
156MP0002084_abnormal_developmental_patter0.13247475
157MP0005319_abnormal_enzyme/_coenzyme0.13087312
158MP0002693_abnormal_pancreas_physiology0.12985235
159MP0002405_respiratory_system_inflammati0.12666293
160MP0000001_mammalian_phenotype0.12230508
161MP0004134_abnormal_chest_morphology0.12116132
162MP0005195_abnormal_posterior_eye0.11649067

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.41578126
2Abnormal respiratory motile cilium morphology (HP:0005938)9.24806189
3Abnormal respiratory epithelium morphology (HP:0012253)9.24806189
4Severe visual impairment (HP:0001141)7.89874683
5Abnormal ciliary motility (HP:0012262)7.63085825
6Rhinitis (HP:0012384)7.53125199
7Chronic bronchitis (HP:0004469)7.26939669
8Infertility (HP:0000789)6.75947536
9Nasal polyposis (HP:0100582)6.39732165
10Chronic hepatic failure (HP:0100626)5.95510721
11Abnormality of the nasal mucosa (HP:0000433)5.26084287
12Hyperkalemia (HP:0002153)4.85950753
13Resting tremor (HP:0002322)4.80095002
14Bony spicule pigmentary retinopathy (HP:0007737)4.75705859
15Attenuation of retinal blood vessels (HP:0007843)4.73786469
16Male infertility (HP:0003251)4.69853522
17Bronchitis (HP:0012387)4.63367254
18Bronchiectasis (HP:0002110)4.46144420
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.37604749
20Abnormality of macular pigmentation (HP:0008002)4.34606523
21Cone-rod dystrophy (HP:0000548)4.31676081
22Nephronophthisis (HP:0000090)4.24064867
23Hypoplasia of the thymus (HP:0000778)3.86601918
24Hypoalphalipoproteinemia (HP:0003233)3.86599711
25Potter facies (HP:0002009)3.84803079
26Facial shape deformation (HP:0011334)3.84803079
27Progressive sensorineural hearing impairment (HP:0000408)3.66226361
28Menstrual irregularities (HP:0000858)3.58288387
29Abnormal spermatogenesis (HP:0008669)3.55285148
30Abnormal rod and cone electroretinograms (HP:0008323)3.53244865
31Recurrent sinusitis (HP:0011108)3.52838194
32Aplasia/Hypoplasia of the earlobes (HP:0009906)3.35060583
33Postural instability (HP:0002172)3.34725207
34Recurrent otitis media (HP:0000403)3.33628176
35Abnormality of the renal medulla (HP:0100957)3.23067511
36Renovascular hypertension (HP:0100817)3.22748571
37Insulin-resistant diabetes mellitus (HP:0000831)3.05381018
38Amelogenesis imperfecta (HP:0000705)2.96722610
39Portal hypertension (HP:0001409)2.96721508
40Enlarged epiphyses (HP:0010580)2.95466650
41Tubulointerstitial nephritis (HP:0001970)2.95301200
42Abnormality of dental color (HP:0011073)2.91847649
43Recurrent bronchitis (HP:0002837)2.87652311
44Progressive cerebellar ataxia (HP:0002073)2.85214710
45Hypoplastic ischia (HP:0003175)2.80087021
46Abnormality of the hepatic vasculature (HP:0006707)2.72468839
47Generalized aminoaciduria (HP:0002909)2.72400216
48Abnormality of potassium homeostasis (HP:0011042)2.66517031
49Tubular atrophy (HP:0000092)2.62110126
50Molar tooth sign on MRI (HP:0002419)2.57811442
51Abnormality of midbrain morphology (HP:0002418)2.57811442
52Impulsivity (HP:0100710)2.53936621
53Abnormality of the ischium (HP:0003174)2.53577777
54Gonadotropin excess (HP:0000837)2.52278730
55Hyperuricemia (HP:0002149)2.51866716
56Increased purine levels (HP:0004368)2.51866716
57Tubulointerstitial abnormality (HP:0001969)2.49690176
58Abnormality of the costochondral junction (HP:0000919)2.47724519
59Medial flaring of the eyebrow (HP:0010747)2.41649055
60Abnormality of the aortic arch (HP:0012303)2.34710704
61Progressive hearing impairment (HP:0001730)2.32275430
62Myokymia (HP:0002411)2.30898316
63Unilateral renal agenesis (HP:0000122)2.27959009
64Polyuria (HP:0000103)2.24165303
65Azoospermia (HP:0000027)2.23593097
66Subcapsular cataract (HP:0000523)2.23504453
67Congenital malformation of the right heart (HP:0011723)2.21214286
68Double outlet right ventricle (HP:0001719)2.21214286
69Flattened epiphyses (HP:0003071)2.18317235
70Abnormal gallbladder physiology (HP:0012438)2.15703747
71Cholecystitis (HP:0001082)2.15703747
72Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.14615877
73Dyschromatopsia (HP:0007641)2.08228486
74Intellectual disability, moderate (HP:0002342)2.07565321
75Osteomalacia (HP:0002749)2.06119396
76Recurrent pneumonia (HP:0006532)2.03693007
77Renal Fanconi syndrome (HP:0001994)2.01261792
78Dynein arm defect of respiratory motile cilia (HP:0012255)13.5247482
79Absent/shortened dynein arms (HP:0200106)13.5247482
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2676114
81Tubulointerstitial fibrosis (HP:0005576)1.98981706
82Ventricular tachycardia (HP:0004756)1.98771095
83Abnormality of the lower motor neuron (HP:0002366)1.97434175
84Hypophosphatemic rickets (HP:0004912)1.95341316
85Widely patent fontanelles and sutures (HP:0004492)1.93596903
86Hyponatremia (HP:0002902)1.93310506
87Focal segmental glomerulosclerosis (HP:0000097)1.91825259
88Postaxial foot polydactyly (HP:0001830)1.89518365
89Optic nerve hypoplasia (HP:0000609)1.89186044
90Upper limb muscle weakness (HP:0003484)1.88245537
91Spastic tetraparesis (HP:0001285)1.87951327
92Hypolipoproteinemia (HP:0010981)1.87809728
93Decreased central vision (HP:0007663)1.86540685
94Recurrent corneal erosions (HP:0000495)1.82085148
95Stage 5 chronic kidney disease (HP:0003774)1.81535964
96Abnormality of the epiphysis of the femoral head (HP:0010574)1.78498055
97Insulin resistance (HP:0000855)1.77999568
98Epiphyseal dysplasia (HP:0002656)1.77433121
99Photophobia (HP:0000613)1.75737005
100Congenital hepatic fibrosis (HP:0002612)1.74888651
101Abnormality of the parathyroid morphology (HP:0011766)1.74727740
102Heterotopia (HP:0002282)1.73869850
103Fibular hypoplasia (HP:0003038)1.73826342
104Polydipsia (HP:0001959)1.72705940
105Abnormal drinking behavior (HP:0030082)1.72705940
106Choroideremia (HP:0001139)1.72457693
107Abnormality of the renal cortex (HP:0011035)1.72313469
108Abnormality of purine metabolism (HP:0004352)1.71870163
109Occipital encephalocele (HP:0002085)1.70695739
110Bile duct proliferation (HP:0001408)1.70624778
111Abnormal biliary tract physiology (HP:0012439)1.70624778
112Glycosuria (HP:0003076)1.70328811
113Abnormality of urine glucose concentration (HP:0011016)1.70328811
114Bradycardia (HP:0001662)1.70230796
115Flat capital femoral epiphysis (HP:0003370)1.69680492
116Congenital sensorineural hearing impairment (HP:0008527)1.68171192
117Short ribs (HP:0000773)1.66252975
118Abnormality of chloride homeostasis (HP:0011422)1.65313592
119Abnormality of renal excretion (HP:0011036)1.61988574
120Amyotrophic lateral sclerosis (HP:0007354)1.61128397
121Hypoplasia of the capital femoral epiphysis (HP:0003090)1.60186917
122Abnormality of the dental root (HP:0006486)1.60059630
123Taurodontia (HP:0000679)1.60059630
124Abnormality of permanent molar morphology (HP:0011071)1.60059630
125Bell-shaped thorax (HP:0001591)1.59727712
126Oculomotor apraxia (HP:0000657)1.57656494
127Absent frontal sinuses (HP:0002688)1.52971298
128Abnormality of dentin (HP:0010299)1.52846132
129Asymmetric septal hypertrophy (HP:0001670)1.52266504
130Hemorrhage of the eye (HP:0011885)1.49673907
131Abnormality of molar morphology (HP:0011070)1.48495151
132Abnormality of molar (HP:0011077)1.48495151
133Abnormality of the dental pulp (HP:0006479)1.47080234
134Renal dysplasia (HP:0000110)1.46930095
135Postaxial hand polydactyly (HP:0001162)1.46568578
136Cystic liver disease (HP:0006706)1.45121006
137Microglossia (HP:0000171)1.45012259
138Chronic sinusitis (HP:0011109)1.44022703
139Facial cleft (HP:0002006)1.41439742
140J-shaped sella turcica (HP:0002680)1.40166432
141Deformed sella turcica (HP:0002681)1.38893430
142Aplasia/Hypoplasia of the lens (HP:0008063)1.34915198
143Pancreatic fibrosis (HP:0100732)1.34100721
144Bundle branch block (HP:0011710)1.33176970
145Abnormal urine output (HP:0012590)1.30354440
146Impaired proprioception (HP:0010831)1.30316956
147Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.29980558
148Decreased electroretinogram (ERG) amplitude (HP:0000654)1.29404087
149Congenital primary aphakia (HP:0007707)1.29347398
150Neurofibrillary tangles (HP:0002185)1.28953323
151Gait imbalance (HP:0002141)1.28876070
152Aplasia/Hypoplasia of the tongue (HP:0010295)1.28761242
153Supernumerary spleens (HP:0009799)1.25486085
154Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.25256595
155Absent epiphyses (HP:0010577)1.25256595
156Short thorax (HP:0010306)1.22875433
157Broad distal phalanx of finger (HP:0009836)1.21636465
158Nephropathy (HP:0000112)1.20526684
159Constricted visual fields (HP:0001133)1.19485619
160Median cleft lip (HP:0000161)1.17945907
161Hemiparesis (HP:0001269)1.17411104
162Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.16183445
163Abnormality of ocular smooth pursuit (HP:0000617)1.15534512
164Abnormality of saccadic eye movements (HP:0000570)1.14088162
165Truncal obesity (HP:0001956)1.13181967
166Vascular calcification (HP:0004934)1.12358018
167True hermaphroditism (HP:0010459)1.10968147
168Pachygyria (HP:0001302)1.10220768
169Easy fatigability (HP:0003388)1.09681692

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.75056216
2PDK48.75056216
3PDK25.67889659
4TESK15.37243167
5PRKD34.69888481
6ICK3.93991483
7DDR23.69400965
8INSRR3.51596709
9BRD43.45515504
10PLK23.31889687
11MAP4K22.89705213
12PTK2B2.27624261
13WNK42.21132713
14PNCK2.17742523
15STK392.07422494
16PIK3CG1.81994272
17TIE11.77984500
18MST1R1.72134337
19STK381.51436536
20NEK21.49595288
21DYRK1B1.46902858
22AKT31.32988899
23PDK11.11262676
24CDK71.07310100
25TYRO30.93237155
26WNK10.89674938
27SIK20.88810326
28MAPK150.87587985
29CAMK1D0.84387211
30DYRK30.80516990
31MAP3K90.74918821
32KSR20.73603496
33PASK0.69399022
34CCNB10.68595839
35IRAK10.68252660
36MAP3K110.65772185
37STK30.64955380
38LATS10.64326502
39CAMK1G0.63687015
40MAP2K60.60358199
41LMTK20.59994739
42PDPK10.59643777
43MAP2K20.59213613
44TTK0.58261053
45RPS6KA20.58121711
46LATS20.57775785
47CAMK10.57674916
48CDK30.56182475
49SGK4940.56113014
50SGK2230.56113014
51MAP3K20.55432006
52RIPK40.52289570
53TESK20.52100052
54CHEK20.51530085
55ROCK10.50618359
56PINK10.46157266
57EEF2K0.45986237
58PRKAA20.42901501
59CHEK10.42468893
60UHMK10.40694629
61STK38L0.39024568
62PAK10.38843481
63WEE10.38626823
64MAP3K80.36831846
65TSSK60.35011430
66OXSR10.33270290
67CDC70.33158503
68IRAK20.33009607
69NTRK20.32855322
70MARK10.31296942
71PAK20.31276769
72JAK30.30511157
73ATR0.29462085
74PRKCG0.29306650
75ATM0.29088080
76MAP3K10.28805111
77SGK10.28151336
78CAMK40.27997434
79RPS6KC10.27792029
80RPS6KL10.27792029
81PLK40.27665512
82RPS6KA60.27088081
83MUSK0.26893590
84MTOR0.26651136
85NEK60.22871818
86MAP3K100.22848906
87MAPK140.22259870
88VRK10.21282841
89MAPKAPK50.21096391
90SGK20.20725686
91MARK20.20608153
92CAMKK10.19975833
93NTRK30.19388198
94BRSK20.19024667
95ARAF0.18494936
96MET0.17820636
97PRKAA10.17683373
98MAPK100.17308423
99RPS6KB10.14734207
100PAK40.14610779
101PLK10.13889384
102FER0.13634434
103PRKCZ0.13608942
104CDK120.12767725
105AKT10.12503971
106PRKCQ0.11363861
107MINK10.11007330
108MAPK110.10847262
109TNIK0.10128659
110CDK150.10127704
111PRKACA0.08311204
112CDK180.07671617
113ACVR1B0.07544330
114CSNK1D0.06939687
115CDK11A0.06785998
116GSK3B0.06557514
117MAPK90.06480170
118BRSK10.06370699
119CSNK2A10.05855822
120PRKG20.05798232
121SGK30.05111808
122STK100.05055585
123MARK30.04576367
124RPS6KA10.03901591
125CDK10.03858990
126PRKG10.03749973
127CDK20.03407829
128CDK140.03404598
129CDK60.03283969
130PRKACG0.02987491
131WNK30.02743383
132ZAP700.02475778
133MAPK80.02267488
134CSNK2A20.02100501
135PRKCB0.01308547
136MAP3K40.01257433
137STK110.00806877
138PKN10.00583523
139PDGFRB0.00439727
140EGFR0.00393460
141CAMK2A0.00223110
142MAPK1-0.0346876
143PAK6-0.0282071
144RPS6KA3-0.0192037
145PIM1-0.0191538
146MAP3K5-0.0168183
147CDK4-0.0136476
148CSF1R-0.0095311
149PRKCA-0.0093810
150PRKCD-0.0087918
151BRAF-0.0050420
152BMPR1B-0.0039820
153PRKACB-0.0038152
154PRKDC-0.0021570

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.31210568
2Fatty acid biosynthesis_Homo sapiens_hsa000614.38536310
3Vitamin B6 metabolism_Homo sapiens_hsa007503.86918569
4Pyruvate metabolism_Homo sapiens_hsa006203.80759720
5* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.72857996
6Olfactory transduction_Homo sapiens_hsa047403.51459135
7Propanoate metabolism_Homo sapiens_hsa006402.93988955
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.91176404
9Linoleic acid metabolism_Homo sapiens_hsa005912.76476835
10Glucagon signaling pathway_Homo sapiens_hsa049222.70524790
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.67621548
12Butanoate metabolism_Homo sapiens_hsa006502.50108985
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.29681242
14Basal transcription factors_Homo sapiens_hsa030222.27444523
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.27026919
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.14331705
17Selenocompound metabolism_Homo sapiens_hsa004502.04526796
18Glycerolipid metabolism_Homo sapiens_hsa005612.04432067
19Pentose phosphate pathway_Homo sapiens_hsa000301.93575320
20PPAR signaling pathway_Homo sapiens_hsa033201.92093602
21Dorso-ventral axis formation_Homo sapiens_hsa043201.88607810
22Oocyte meiosis_Homo sapiens_hsa041141.80113257
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.76794633
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.73106413
25Fructose and mannose metabolism_Homo sapiens_hsa000511.63387454
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.60931509
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.53532464
28Mineral absorption_Homo sapiens_hsa049781.52558367
29Fanconi anemia pathway_Homo sapiens_hsa034601.48167913
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.45659460
31Amphetamine addiction_Homo sapiens_hsa050311.44778186
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43314432
33Fatty acid degradation_Homo sapiens_hsa000711.39589982
34Fatty acid metabolism_Homo sapiens_hsa012121.39425199
35Phenylalanine metabolism_Homo sapiens_hsa003601.37864120
36Type II diabetes mellitus_Homo sapiens_hsa049301.37316569
37Fat digestion and absorption_Homo sapiens_hsa049751.33183151
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.31757946
39Phototransduction_Homo sapiens_hsa047441.27279670
40Cardiac muscle contraction_Homo sapiens_hsa042601.27036644
41Ether lipid metabolism_Homo sapiens_hsa005651.24585607
42Antigen processing and presentation_Homo sapiens_hsa046121.21579098
43Type I diabetes mellitus_Homo sapiens_hsa049401.20694828
44Huntingtons disease_Homo sapiens_hsa050161.17473454
45Renin secretion_Homo sapiens_hsa049241.16950160
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13770151
47mRNA surveillance pathway_Homo sapiens_hsa030151.13450158
48Allograft rejection_Homo sapiens_hsa053301.06183180
49Purine metabolism_Homo sapiens_hsa002301.01469414
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99615907
51Autoimmune thyroid disease_Homo sapiens_hsa053200.98645339
52RNA transport_Homo sapiens_hsa030130.96600137
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95084797
54Arginine and proline metabolism_Homo sapiens_hsa003300.94512336
55Morphine addiction_Homo sapiens_hsa050320.94494571
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92891362
57Arginine biosynthesis_Homo sapiens_hsa002200.92528611
58* Carbon metabolism_Homo sapiens_hsa012000.89503447
59Graft-versus-host disease_Homo sapiens_hsa053320.87283238
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.86124600
61Glutathione metabolism_Homo sapiens_hsa004800.85761538
62Chemical carcinogenesis_Homo sapiens_hsa052040.78935764
63Nicotine addiction_Homo sapiens_hsa050330.78692144
64ABC transporters_Homo sapiens_hsa020100.78532221
65Collecting duct acid secretion_Homo sapiens_hsa049660.77797018
66Insulin secretion_Homo sapiens_hsa049110.76517527
67Hedgehog signaling pathway_Homo sapiens_hsa043400.76278447
68Bile secretion_Homo sapiens_hsa049760.76178084
69Influenza A_Homo sapiens_hsa051640.76153655
70Thyroid hormone synthesis_Homo sapiens_hsa049180.74822069
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.74705451
72Nitrogen metabolism_Homo sapiens_hsa009100.73436316
73Estrogen signaling pathway_Homo sapiens_hsa049150.73004830
74Arachidonic acid metabolism_Homo sapiens_hsa005900.72596636
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72268910
76Long-term potentiation_Homo sapiens_hsa047200.71410774
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68578954
78Renin-angiotensin system_Homo sapiens_hsa046140.68385034
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.66894983
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66394715
81Viral myocarditis_Homo sapiens_hsa054160.66279203
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63823526
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.63000292
84Glutamatergic synapse_Homo sapiens_hsa047240.60752329
85Legionellosis_Homo sapiens_hsa051340.60455172
86Tyrosine metabolism_Homo sapiens_hsa003500.60167346
87Calcium signaling pathway_Homo sapiens_hsa040200.56760584
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55322142
89Protein digestion and absorption_Homo sapiens_hsa049740.54081616
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53279563
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53036678
92Salivary secretion_Homo sapiens_hsa049700.50959444
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50909022
94Pancreatic secretion_Homo sapiens_hsa049720.50780600
95MAPK signaling pathway_Homo sapiens_hsa040100.50338528
96Serotonergic synapse_Homo sapiens_hsa047260.49798250
97Inositol phosphate metabolism_Homo sapiens_hsa005620.48872654
98Tight junction_Homo sapiens_hsa045300.46639393
99Endocytosis_Homo sapiens_hsa041440.46470352
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46464785
101AMPK signaling pathway_Homo sapiens_hsa041520.43642719
102Gastric acid secretion_Homo sapiens_hsa049710.41711559
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40972830
104Taste transduction_Homo sapiens_hsa047420.39343259
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38955064
106GABAergic synapse_Homo sapiens_hsa047270.38739248
107Sulfur metabolism_Homo sapiens_hsa009200.38698434
108Synaptic vesicle cycle_Homo sapiens_hsa047210.38585719
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.36912017
110VEGF signaling pathway_Homo sapiens_hsa043700.34556331
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34290966
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33038513
113* Metabolic pathways_Homo sapiens_hsa011000.32904823
114Cholinergic synapse_Homo sapiens_hsa047250.32854707
115Systemic lupus erythematosus_Homo sapiens_hsa053220.32696503
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32005970
117cAMP signaling pathway_Homo sapiens_hsa040240.30163662
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.29759029
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27795496
120Circadian entrainment_Homo sapiens_hsa047130.27324079
121Oxytocin signaling pathway_Homo sapiens_hsa049210.24598512
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21153355
123Pyrimidine metabolism_Homo sapiens_hsa002400.20964031
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.20722827
125N-Glycan biosynthesis_Homo sapiens_hsa005100.19114952
126Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.17574402
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.17392795
128Acute myeloid leukemia_Homo sapiens_hsa052210.16029756
129ECM-receptor interaction_Homo sapiens_hsa045120.15502434
130* Biosynthesis of amino acids_Homo sapiens_hsa012300.12987346
131Cocaine addiction_Homo sapiens_hsa050300.12769606
132B cell receptor signaling pathway_Homo sapiens_hsa046620.09678186
133Wnt signaling pathway_Homo sapiens_hsa043100.09316916
134Alcoholism_Homo sapiens_hsa050340.06908050
135HIF-1 signaling pathway_Homo sapiens_hsa040660.06424672
136Retinol metabolism_Homo sapiens_hsa008300.05200709
137Salmonella infection_Homo sapiens_hsa051320.05143150
138RNA degradation_Homo sapiens_hsa030180.04869260

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