

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | defense response to fungus (GO:0050832) | 9.79001059 |
| 2 | leukocyte migration involved in inflammatory response (GO:0002523) | 9.73233816 |
| 3 | disruption of cells of other organism involved in symbiotic interaction (GO:0051818) | 8.00579615 |
| 4 | killing of cells in other organism involved in symbiotic interaction (GO:0051883) | 8.00579615 |
| 5 | response to fungus (GO:0009620) | 7.39326477 |
| 6 | sequestering of metal ion (GO:0051238) | 7.24872814 |
| 7 | disruption of cells of other organism (GO:0044364) | 6.31034790 |
| 8 | killing of cells of other organism (GO:0031640) | 6.31034790 |
| 9 | neutrophil activation involved in immune response (GO:0002283) | 6.24327624 |
| 10 | neutrophil mediated immunity (GO:0002446) | 6.23669339 |
| 11 | production of molecular mediator involved in inflammatory response (GO:0002532) | 5.89311488 |
| 12 | response to peptidoglycan (GO:0032494) | 5.86956762 |
| 13 | respiratory burst (GO:0045730) | 5.59499355 |
| 14 | cellular extravasation (GO:0045123) | 5.54717631 |
| 15 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 5.49980563 |
| 16 | oxygen transport (GO:0015671) | 5.43813986 |
| 17 | chronic inflammatory response (GO:0002544) | 5.23064661 |
| 18 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 5.03202029 |
| 19 | neutrophil activation (GO:0042119) | 4.99766915 |
| 20 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 4.97105678 |
| 21 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 4.97105678 |
| 22 | modulation by symbiont of host immune response (GO:0052553) | 4.97105678 |
| 23 | positive regulation by symbiont of host defense response (GO:0052509) | 4.97105678 |
| 24 | modulation by symbiont of host defense response (GO:0052031) | 4.97105678 |
| 25 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 4.97105678 |
| 26 | antibacterial humoral response (GO:0019731) | 4.93594833 |
| 27 | antimicrobial humoral response (GO:0019730) | 4.83824488 |
| 28 | myeloid leukocyte mediated immunity (GO:0002444) | 4.82742909 |
| 29 | positive regulation of gamma-delta T cell activation (GO:0046645) | 4.75645828 |
| 30 | pentose-phosphate shunt (GO:0006098) | 4.74720097 |
| 31 | mucosal immune response (GO:0002385) | 4.62724094 |
| 32 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.62404164 |
| 33 | * detection of other organism (GO:0098543) | 4.53592977 |
| 34 | innate immune response in mucosa (GO:0002227) | 4.50508977 |
| 35 | granulocyte activation (GO:0036230) | 4.45657429 |
| 36 | gas transport (GO:0015669) | 4.41395220 |
| 37 | macrophage differentiation (GO:0030225) | 4.39861751 |
| 38 | organ or tissue specific immune response (GO:0002251) | 4.36951364 |
| 39 | neutrophil chemotaxis (GO:0030593) | 4.32614258 |
| 40 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.29750407 |
| 41 | * detection of bacterium (GO:0016045) | 4.29679457 |
| 42 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 4.26994876 |
| 43 | NADPH regeneration (GO:0006740) | 4.25543441 |
| 44 | neutrophil migration (GO:1990266) | 4.20101884 |
| 45 | negative regulation of phagocytosis (GO:0050765) | 4.18060990 |
| 46 | negative regulation of growth of symbiont in host (GO:0044130) | 4.13236367 |
| 47 | negative regulation of growth of symbiont involved in interaction with host (GO:0044146) | 4.13236367 |
| 48 | modulation of growth of symbiont involved in interaction with host (GO:0044144) | 4.13236367 |
| 49 | regulation of growth of symbiont in host (GO:0044126) | 4.13236367 |
| 50 | leukotriene biosynthetic process (GO:0019370) | 4.12115717 |
| 51 | macrophage activation involved in immune response (GO:0002281) | 4.08090900 |
| 52 | superoxide anion generation (GO:0042554) | 4.03503721 |
| 53 | positive regulation of mast cell activation (GO:0033005) | 3.97798343 |
| 54 | leukotriene metabolic process (GO:0006691) | 3.89387449 |
| 55 | leukocyte cell-cell adhesion (GO:0007159) | 3.86306095 |
| 56 | positive regulation of lamellipodium assembly (GO:0010592) | 3.84992101 |
| 57 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 3.79455180 |
| 58 | leukocyte mediated cytotoxicity (GO:0001909) | 3.79236834 |
| 59 | negative regulation of interleukin-6 production (GO:0032715) | 3.78436142 |
| 60 | negative regulation of interleukin-8 production (GO:0032717) | 3.76839069 |
| 61 | * detection of external biotic stimulus (GO:0098581) | 3.76630585 |
| 62 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.76143780 |
| 63 | negative regulation of interleukin-12 production (GO:0032695) | 3.75808600 |
| 64 | reactive oxygen species biosynthetic process (GO:1903409) | 3.75024173 |
| 65 | actin nucleation (GO:0045010) | 3.72510047 |
| 66 | regulation of mast cell activation (GO:0033003) | 3.70810009 |
| 67 | cell killing (GO:0001906) | 3.70570777 |
| 68 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 3.67237438 |
| 69 | regulation of respiratory burst (GO:0060263) | 3.66513414 |
| 70 | granulocyte migration (GO:0097530) | 3.65791815 |
| 71 | regulation of toll-like receptor 4 signaling pathway (GO:0034143) | 3.65389043 |
| 72 | detection of molecule of bacterial origin (GO:0032490) | 3.65129528 |
| 73 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.64695024 |
| 74 | response to host immune response (GO:0052572) | 3.64695024 |
| 75 | granulocyte chemotaxis (GO:0071621) | 3.62542825 |
| 76 | intracellular estrogen receptor signaling pathway (GO:0030520) | 3.62481467 |
| 77 | negative regulation of erythrocyte differentiation (GO:0045647) | 3.61811907 |
| 78 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.60012088 |
| 79 | response to host (GO:0075136) | 3.59375108 |
| 80 | response to host defenses (GO:0052200) | 3.59375108 |
| 81 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.59375108 |
| 82 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.55365746 |
| 83 | regulation of leukocyte degranulation (GO:0043300) | 3.54181156 |
| 84 | myeloid cell activation involved in immune response (GO:0002275) | 3.49321676 |
| 85 | hydrogen peroxide biosynthetic process (GO:0050665) | 3.47917212 |
| 86 | phagosome maturation (GO:0090382) | 3.47083964 |
| 87 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.46400309 |
| 88 | microglial cell activation (GO:0001774) | 3.42765891 |
| 89 | positive regulation of toll-like receptor signaling pathway (GO:0034123) | 3.41527738 |
| 90 | regulation of mast cell degranulation (GO:0043304) | 3.40125365 |
| 91 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 3.37709195 |
| 92 | cellular response to zinc ion (GO:0071294) | 3.36255995 |
| 93 | * defense response to bacterium (GO:0042742) | 3.36185674 |
| 94 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 3.35382847 |
| 95 | glucose catabolic process (GO:0006007) | 3.34644808 |
| 96 | * defense response to Gram-positive bacterium (GO:0050830) | 3.33854414 |
| 97 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.33481600 |
| 98 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.33481600 |
| 99 | regulation of gamma-delta T cell activation (GO:0046643) | 3.32869490 |
| 100 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.30527728 |
| 101 | positive regulation of osteoblast proliferation (GO:0033690) | 3.28764695 |
| 102 | macrophage activation (GO:0042116) | 3.28622453 |
| 103 | * detection of biotic stimulus (GO:0009595) | 3.27104725 |
| 104 | protoporphyrinogen IX metabolic process (GO:0046501) | 3.25181092 |
| 105 | hemoglobin metabolic process (GO:0020027) | 3.23759108 |
| 106 | lipoxygenase pathway (GO:0019372) | 3.21788618 |
| 107 | regulation of regulated secretory pathway (GO:1903305) | 3.20681470 |
| 108 | * response to bacterium (GO:0009617) | 3.19504303 |
| 109 | positive regulation of lamellipodium organization (GO:1902745) | 3.19485665 |
| 110 | leukocyte degranulation (GO:0043299) | 3.19359171 |
| 111 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 3.18588532 |
| 112 | positive regulation of mast cell degranulation (GO:0043306) | 3.18588532 |
| 113 | hepatocyte differentiation (GO:0070365) | 3.18496786 |
| 114 | citrulline biosynthetic process (GO:0019240) | 3.16059029 |
| 115 | regulation of mast cell activation involved in immune response (GO:0033006) | 3.13026404 |
| 116 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 3.12304932 |
| 117 | negative regulation of cell killing (GO:0031342) | 3.12106661 |
| 118 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.12106661 |
| 119 | sequestering of actin monomers (GO:0042989) | 3.09246227 |
| 120 | response to muramyl dipeptide (GO:0032495) | 3.08897336 |
| 121 | protoporphyrinogen IX biosynthetic process (GO:0006782) | 3.08437906 |
| 122 | regulation of RIG-I signaling pathway (GO:0039535) | 3.07596483 |
| 123 | response to interleukin-15 (GO:0070672) | 3.07502041 |
| 124 | pentose metabolic process (GO:0019321) | 3.06641976 |
| 125 | positive regulation of myeloid leukocyte mediated immunity (GO:0002888) | 3.04051373 |
| 126 | activated T cell proliferation (GO:0050798) | 3.02969117 |
| 127 | germinal center formation (GO:0002467) | 3.00940248 |
| 128 | positive regulation of B cell differentiation (GO:0045579) | 2.99768237 |
| 129 | regulation of hydrogen peroxide metabolic process (GO:0010310) | 2.99616938 |
| 130 | mast cell activation (GO:0045576) | 2.98430462 |
| 131 | interaction with symbiont (GO:0051702) | 2.96241215 |
| 132 | myeloid leukocyte migration (GO:0097529) | 2.89318491 |
| 133 | antigen processing and presentation of endogenous antigen (GO:0019883) | 2.87212942 |
| 134 | diterpenoid biosynthetic process (GO:0016102) | 2.84219672 |
| 135 | immunoglobulin mediated immune response (GO:0016064) | 2.81803263 |
| 136 | barbed-end actin filament capping (GO:0051016) | 2.79405379 |
| 137 | primary alcohol catabolic process (GO:0034310) | 2.78682606 |
| 138 | response to zinc ion (GO:0010043) | 2.75589502 |
| 139 | dendritic cell migration (GO:0036336) | 2.72870264 |
| 140 | hepatocyte apoptotic process (GO:0097284) | 2.68634598 |
| 141 | leukocyte chemotaxis (GO:0030595) | 2.68241377 |
| 142 | * defense response to other organism (GO:0098542) | 2.66784947 |
| 143 | NADP metabolic process (GO:0006739) | 2.62921537 |
| 144 | leukocyte aggregation (GO:0070486) | 10.5732031 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 5.44393449 |
| 2 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 4.19236999 |
| 3 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.79600119 |
| 4 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.77039900 |
| 5 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.48720292 |
| 6 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.26427512 |
| 7 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 2.85078188 |
| 8 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.80597780 |
| 9 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 2.80146230 |
| 10 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.75912300 |
| 11 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.69941119 |
| 12 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.64191097 |
| 13 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.64026640 |
| 14 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.63239790 |
| 15 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.56655796 |
| 16 | GATA1_22025678_ChIP-Seq_K562_Human | 2.52181442 |
| 17 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.51589171 |
| 18 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.47799170 |
| 19 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.44237462 |
| 20 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.39881732 |
| 21 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.32357405 |
| 22 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.28164222 |
| 23 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.27775556 |
| 24 | VDR_24763502_ChIP-Seq_THP-1_Human | 2.25896292 |
| 25 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.24135221 |
| 26 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 2.20040793 |
| 27 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.18071931 |
| 28 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 2.13593948 |
| 29 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.12754550 |
| 30 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 2.12690179 |
| 31 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.10118594 |
| 32 | MYB_26560356_Chip-Seq_TH2_Human | 2.08372867 |
| 33 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.03729338 |
| 34 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 2.00143945 |
| 35 | MAF_26560356_Chip-Seq_TH1_Human | 1.96848013 |
| 36 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.87000782 |
| 37 | * RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.86073051 |
| 38 | UTX_26944678_Chip-Seq_JUKART_Human | 1.83796767 |
| 39 | * STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.83237057 |
| 40 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.80787223 |
| 41 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.78888546 |
| 42 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.76760218 |
| 43 | SPI1_23127762_ChIP-Seq_K562_Human | 1.75864163 |
| 44 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.75465711 |
| 45 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.73926151 |
| 46 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.64918296 |
| 47 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.59817168 |
| 48 | MYB_26560356_Chip-Seq_TH1_Human | 1.58311160 |
| 49 | MYC_22102868_ChIP-Seq_BL_Human | 1.58130832 |
| 50 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.53987294 |
| 51 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.52926050 |
| 52 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.51753363 |
| 53 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.49870893 |
| 54 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.49575857 |
| 55 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.47676561 |
| 56 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.47587046 |
| 57 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.46200340 |
| 58 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.45797787 |
| 59 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.45692160 |
| 60 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.45454258 |
| 61 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.41159288 |
| 62 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.41024439 |
| 63 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.40059116 |
| 64 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.37275535 |
| 65 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.36653353 |
| 66 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.36191709 |
| 67 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.36112562 |
| 68 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.35235462 |
| 69 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.34100169 |
| 70 | * BCOR_27268052_Chip-Seq_Bcells_Human | 1.33831788 |
| 71 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.33152012 |
| 72 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.32492449 |
| 73 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.29904141 |
| 74 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.27015376 |
| 75 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.25960117 |
| 76 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.25074554 |
| 77 | GATA1_19941826_ChIP-Seq_K562_Human | 1.24357230 |
| 78 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.23486358 |
| 79 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.21988129 |
| 80 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 1.21140156 |
| 81 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.19875036 |
| 82 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.19553695 |
| 83 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.19407419 |
| 84 | GATA2_19941826_ChIP-Seq_K562_Human | 1.19206024 |
| 85 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.18088345 |
| 86 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.15964521 |
| 87 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.15952236 |
| 88 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.15521800 |
| 89 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.15346687 |
| 90 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.15011060 |
| 91 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.14690870 |
| 92 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.14361816 |
| 93 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.12553842 |
| 94 | MAF_26560356_Chip-Seq_TH2_Human | 1.10795447 |
| 95 | SOX2_20726797_ChIP-Seq_SW620_Human | 1.09882230 |
| 96 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.08954868 |
| 97 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.08172074 |
| 98 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.05812833 |
| 99 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.05703214 |
| 100 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.05277528 |
| 101 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.05098516 |
| 102 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.04477755 |
| 103 | * SPI1_20517297_ChIP-Seq_HL60_Human | 1.02673718 |
| 104 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.02158870 |
| 105 | * BCL6_27268052_Chip-Seq_Bcells_Human | 1.01795585 |
| 106 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.01096917 |
| 107 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 1.00639354 |
| 108 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.98814635 |
| 109 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.98415981 |
| 110 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.98366108 |
| 111 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.98145050 |
| 112 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.97311735 |
| 113 | * P68_20966046_ChIP-Seq_HELA_Human | 0.96769933 |
| 114 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.95957498 |
| 115 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.94700901 |
| 116 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.94061021 |
| 117 | GATA3_26560356_Chip-Seq_TH2_Human | 0.93624781 |
| 118 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.93509742 |
| 119 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.93227628 |
| 120 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.93227628 |
| 121 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.92281074 |
| 122 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.92278302 |
| 123 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.90854611 |
| 124 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.90526475 |
| 125 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.90034921 |
| 126 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 0.89521750 |
| 127 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.87590623 |
| 128 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.87245113 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003436_decreased_susceptibility_to | 4.23394823 |
| 2 | MP0003303_peritoneal_inflammation | 4.12658855 |
| 3 | * MP0009785_altered_susceptibility_to | 3.91562795 |
| 4 | MP0009278_abnormal_bone_marrow | 2.98462013 |
| 5 | * MP0002419_abnormal_innate_immunity | 2.96648300 |
| 6 | * MP0005025_abnormal_response_to | 2.78893503 |
| 7 | MP0003724_increased_susceptibility_to | 2.67448740 |
| 8 | MP0010234_abnormal_vibrissa_follicle | 2.66280077 |
| 9 | MP0000685_abnormal_immune_system | 2.50289936 |
| 10 | MP0001835_abnormal_antigen_presentation | 2.38692497 |
| 11 | MP0001873_stomach_inflammation | 2.33353343 |
| 12 | MP0003183_abnormal_peptide_metabolism | 2.32689219 |
| 13 | MP0010155_abnormal_intestine_physiology | 2.29843128 |
| 14 | MP0002405_respiratory_system_inflammati | 2.29645051 |
| 15 | MP0005397_hematopoietic_system_phenotyp | 2.26230861 |
| 16 | MP0001545_abnormal_hematopoietic_system | 2.26230861 |
| 17 | MP0001533_abnormal_skeleton_physiology | 2.25468765 |
| 18 | MP0005000_abnormal_immune_tolerance | 2.20367177 |
| 19 | MP0005167_abnormal_blood-brain_barrier | 2.17536954 |
| 20 | * MP0001819_abnormal_immune_cell | 2.15445121 |
| 21 | * MP0002420_abnormal_adaptive_immunity | 2.14709596 |
| 22 | MP0002148_abnormal_hypersensitivity_rea | 2.14529081 |
| 23 | MP0008260_abnormal_autophagy | 2.14002266 |
| 24 | MP0002452_abnormal_antigen_presenting | 2.07419956 |
| 25 | MP0000465_gastrointestinal_hemorrhage | 2.05380526 |
| 26 | MP0001800_abnormal_humoral_immune | 2.04687358 |
| 27 | MP0005464_abnormal_platelet_physiology | 2.02332220 |
| 28 | MP0005671_abnormal_response_to | 1.91804151 |
| 29 | MP0000858_altered_metastatic_potential | 1.89748090 |
| 30 | MP0002723_abnormal_immune_serum | 1.87348825 |
| 31 | MP0001845_abnormal_inflammatory_respons | 1.86842437 |
| 32 | MP0003693_abnormal_embryo_hatching | 1.83192818 |
| 33 | MP0001853_heart_inflammation | 1.82930222 |
| 34 | MP0004264_abnormal_extraembryonic_tissu | 1.82888874 |
| 35 | MP0001790_abnormal_immune_system | 1.82409163 |
| 36 | MP0005387_immune_system_phenotype | 1.82409163 |
| 37 | MP0000490_abnormal_crypts_of | 1.80868393 |
| 38 | MP0000343_altered_response_to | 1.79092083 |
| 39 | MP0002396_abnormal_hematopoietic_system | 1.75143695 |
| 40 | MP0003300_gastrointestinal_ulcer | 1.74193017 |
| 41 | MP0003866_abnormal_defecation | 1.69099066 |
| 42 | MP0002398_abnormal_bone_marrow | 1.65482539 |
| 43 | MP0002277_abnormal_respiratory_mucosa | 1.63577892 |
| 44 | MP0001851_eye_inflammation | 1.63272882 |
| 45 | MP0000716_abnormal_immune_system | 1.60459449 |
| 46 | MP0005083_abnormal_biliary_tract | 1.57806101 |
| 47 | MP0003566_abnormal_cell_adhesion | 1.55603959 |
| 48 | MP0002132_abnormal_respiratory_system | 1.52990758 |
| 49 | MP0001663_abnormal_digestive_system | 1.52811362 |
| 50 | MP0003763_abnormal_thymus_physiology | 1.52280291 |
| 51 | MP0004782_abnormal_surfactant_physiolog | 1.52006422 |
| 52 | MP0003075_altered_response_to | 1.44873185 |
| 53 | MP0009764_decreased_sensitivity_to | 1.43748151 |
| 54 | MP0004808_abnormal_hematopoietic_stem | 1.43467321 |
| 55 | MP0004947_skin_inflammation | 1.41233912 |
| 56 | MP0002429_abnormal_blood_cell | 1.40926776 |
| 57 | MP0006054_spinal_hemorrhage | 1.40647910 |
| 58 | MP0003656_abnormal_erythrocyte_physiolo | 1.40447955 |
| 59 | MP0000689_abnormal_spleen_morphology | 1.37470296 |
| 60 | MP0002722_abnormal_immune_system | 1.34545622 |
| 61 | MP0003806_abnormal_nucleotide_metabolis | 1.34250559 |
| 62 | MP0002166_altered_tumor_susceptibility | 1.32266574 |
| 63 | MP0005023_abnormal_wound_healing | 1.31044528 |
| 64 | MP0003453_abnormal_keratinocyte_physiol | 1.24254363 |
| 65 | MP0003045_fibrosis | 1.23777309 |
| 66 | MP0004883_abnormal_blood_vessel | 1.22319308 |
| 67 | MP0004381_abnormal_hair_follicle | 1.20178038 |
| 68 | MP0004510_myositis | 1.19472044 |
| 69 | MP0002933_joint_inflammation | 1.17062060 |
| 70 | MP0008469_abnormal_protein_level | 1.16542124 |
| 71 | MP0005166_decreased_susceptibility_to | 1.16455371 |
| 72 | MP0002138_abnormal_hepatobiliary_system | 1.15190685 |
| 73 | MP0003448_altered_tumor_morphology | 1.14792458 |
| 74 | MP0005451_abnormal_body_composition | 1.12712936 |
| 75 | MP0009333_abnormal_splenocyte_physiolog | 1.11094732 |
| 76 | MP0003191_abnormal_cellular_cholesterol | 1.09804306 |
| 77 | MP0005381_digestive/alimentary_phenotyp | 1.08211104 |
| 78 | MP0010352_gastrointestinal_tract_polyps | 1.07387922 |
| 79 | MP0002006_tumorigenesis | 1.06970839 |
| 80 | MP0006082_CNS_inflammation | 1.06277112 |
| 81 | MP0005164_abnormal_response_to | 1.04704835 |
| 82 | MP0002998_abnormal_bone_remodeling | 1.03531442 |
| 83 | MP0003186_abnormal_redox_activity | 1.02614352 |
| 84 | MP0005310_abnormal_salivary_gland | 0.98439689 |
| 85 | MP0003878_abnormal_ear_physiology | 0.97516770 |
| 86 | MP0005377_hearing/vestibular/ear_phenot | 0.97516770 |
| 87 | MP0005390_skeleton_phenotype | 0.95617170 |
| 88 | MP0001216_abnormal_epidermal_layer | 0.95359617 |
| 89 | MP0003828_pulmonary_edema | 0.95349396 |
| 90 | MP0002019_abnormal_tumor_incidence | 0.87698411 |
| 91 | MP0000477_abnormal_intestine_morphology | 0.87111806 |
| 92 | MP0002837_dystrophic_cardiac_calcinosis | 0.85869355 |
| 93 | MP0000703_abnormal_thymus_morphology | 0.82894934 |
| 94 | MP0004957_abnormal_blastocyst_morpholog | 0.82383917 |
| 95 | MP0001986_abnormal_taste_sensitivity | 0.81906727 |
| 96 | MP0009765_abnormal_xenobiotic_induced | 0.79164438 |
| 97 | MP0005076_abnormal_cell_differentiation | 0.77829765 |
| 98 | MP0002060_abnormal_skin_morphology | 0.75711191 |
| 99 | MP0003690_abnormal_glial_cell | 0.75433528 |
| 100 | MP0005075_abnormal_melanosome_morpholog | 0.75238124 |
| 101 | MP0003221_abnormal_cardiomyocyte_apopto | 0.75062223 |
| 102 | MP0001764_abnormal_homeostasis | 0.74371708 |
| 103 | MP0001958_emphysema | 0.73970637 |
| 104 | MP0003795_abnormal_bone_structure | 0.73635758 |
| 105 | MP0000015_abnormal_ear_pigmentation | 0.69128545 |
| 106 | MP0005174_abnormal_tail_pigmentation | 0.67432823 |
| 107 | MP0005319_abnormal_enzyme/_coenzyme | 0.66604231 |
| 108 | MP0009931_abnormal_skin_appearance | 0.66595346 |
| 109 | MP0008004_abnormal_stomach_pH | 0.66565122 |
| 110 | MP0004130_abnormal_muscle_cell | 0.62788441 |
| 111 | MP0009763_increased_sensitivity_to | 0.62089401 |
| 112 | MP0000249_abnormal_blood_vessel | 0.62008487 |
| 113 | MP0003172_abnormal_lysosome_physiology | 0.60800755 |
| 114 | MP0000609_abnormal_liver_physiology | 0.60750656 |
| 115 | MP0001191_abnormal_skin_condition | 0.60548387 |
| 116 | MP0004147_increased_porphyrin_level | 0.56847461 |
| 117 | MP0004185_abnormal_adipocyte_glucose | 0.55530298 |
| 118 | MP0008874_decreased_physiological_sensi | 0.55419524 |
| 119 | MP0000604_amyloidosis | 0.54546223 |
| 120 | MP0002133_abnormal_respiratory_system | 0.54025070 |
| 121 | MP0005388_respiratory_system_phenotype | 0.54025070 |
| 122 | MP0005058_abnormal_lysosome_morphology | 0.52721435 |
| 123 | MP0005376_homeostasis/metabolism_phenot | 0.48928207 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Hypochromic microcytic anemia (HP:0004840) | 8.78627637 |
| 2 | Eczematoid dermatitis (HP:0000976) | 8.65824717 |
| 3 | Recurrent abscess formation (HP:0002722) | 8.52682474 |
| 4 | Recurrent bacterial skin infections (HP:0005406) | 7.18183734 |
| 5 | Recurrent gram-negative bacterial infections (HP:0005420) | 6.71477287 |
| 6 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 6.50060989 |
| 7 | Chronic obstructive pulmonary disease (HP:0006510) | 6.13355951 |
| 8 | Obstructive lung disease (HP:0006536) | 6.13355951 |
| 9 | Hypochromic anemia (HP:0001931) | 5.79310874 |
| 10 | Mediastinal lymphadenopathy (HP:0100721) | 4.95969168 |
| 11 | Abnormality of macrophages (HP:0004311) | 4.92262303 |
| 12 | Pustule (HP:0200039) | 4.83255953 |
| 13 | Gingivitis (HP:0000230) | 4.78860708 |
| 14 | Recurrent fungal infections (HP:0002841) | 4.51710495 |
| 15 | Myositis (HP:0100614) | 4.42145917 |
| 16 | Recurrent skin infections (HP:0001581) | 4.25315724 |
| 17 | Urticaria (HP:0001025) | 4.23991684 |
| 18 | Stomatitis (HP:0010280) | 4.14773213 |
| 19 | Gastrointestinal infarctions (HP:0005244) | 3.92839616 |
| 20 | Spontaneous hematomas (HP:0007420) | 3.90649107 |
| 21 | Meningitis (HP:0001287) | 3.80987766 |
| 22 | Cellulitis (HP:0100658) | 3.63907149 |
| 23 | Abnormal hemoglobin (HP:0011902) | 3.63219418 |
| 24 | Toxemia of pregnancy (HP:0100603) | 3.58385295 |
| 25 | Polycythemia (HP:0001901) | 3.56483380 |
| 26 | Cheilitis (HP:0100825) | 3.36234796 |
| 27 | Periodontitis (HP:0000704) | 3.21110417 |
| 28 | Episodic fever (HP:0001954) | 3.13355975 |
| 29 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.08053129 |
| 30 | Chronic otitis media (HP:0000389) | 3.04954449 |
| 31 | Skin ulcer (HP:0200042) | 2.96291849 |
| 32 | Onycholysis (HP:0001806) | 2.94355598 |
| 33 | Anorexia (HP:0002039) | 2.90222896 |
| 34 | Poikilocytosis (HP:0004447) | 2.89750739 |
| 35 | Sepsis (HP:0100806) | 2.85620617 |
| 36 | Petechiae (HP:0000967) | 2.84097353 |
| 37 | Orchitis (HP:0100796) | 2.83719470 |
| 38 | Thrombocytosis (HP:0001894) | 2.72823795 |
| 39 | IgM deficiency (HP:0002850) | 2.62899103 |
| 40 | Vacuolated lymphocytes (HP:0001922) | 2.62637778 |
| 41 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.61814244 |
| 42 | Recurrent cutaneous fungal infections (HP:0011370) | 2.61285773 |
| 43 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.61285773 |
| 44 | Abnormality of the nasal mucosa (HP:0000433) | 2.60755112 |
| 45 | Recurrent pneumonia (HP:0006532) | 2.58180475 |
| 46 | Hemoptysis (HP:0002105) | 2.54542119 |
| 47 | Abnormality of T cell physiology (HP:0011840) | 2.53613892 |
| 48 | Inflammation of the large intestine (HP:0002037) | 2.50240481 |
| 49 | Autoimmune thrombocytopenia (HP:0001973) | 2.49235717 |
| 50 | Peritonitis (HP:0002586) | 2.48656082 |
| 51 | Vasculitis (HP:0002633) | 2.46307333 |
| 52 | Amyloidosis (HP:0011034) | 2.45566177 |
| 53 | Chest pain (HP:0100749) | 2.45516249 |
| 54 | Papilledema (HP:0001085) | 2.43499087 |
| 55 | Interstitial pulmonary disease (HP:0006530) | 2.43437018 |
| 56 | Purpura (HP:0000979) | 2.39086748 |
| 57 | Gastrointestinal inflammation (HP:0004386) | 2.38895955 |
| 58 | Epistaxis (HP:0000421) | 2.38319081 |
| 59 | Osteomyelitis (HP:0002754) | 2.37223579 |
| 60 | Difficulty running (HP:0009046) | 2.35466951 |
| 61 | Eosinophilia (HP:0001880) | 2.29752606 |
| 62 | Hematochezia (HP:0002573) | 2.29154245 |
| 63 | Abnormality of transition element cation homeostasis (HP:0011030) | 2.27450449 |
| 64 | Leukocytosis (HP:0001974) | 2.26859707 |
| 65 | Ureteral stenosis (HP:0000071) | 2.25778980 |
| 66 | Metaphyseal cupping (HP:0003021) | 2.23441042 |
| 67 | Poikiloderma (HP:0001029) | 2.22845115 |
| 68 | Prolonged bleeding time (HP:0003010) | 2.21123848 |
| 69 | Reduced antithrombin III activity (HP:0001976) | 2.20253826 |
| 70 | Arterial thrombosis (HP:0004420) | 2.15807803 |
| 71 | Abnormality of T cells (HP:0002843) | 2.15267204 |
| 72 | Abnormality of the pericardium (HP:0001697) | 2.14627020 |
| 73 | Granulocytopenia (HP:0001913) | 2.14269001 |
| 74 | Increased cerebral lipofuscin (HP:0011813) | 2.14200835 |
| 75 | Recurrent viral infections (HP:0004429) | 2.13798962 |
| 76 | Recurrent lower respiratory tract infections (HP:0002783) | 2.12828500 |
| 77 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.12636668 |
| 78 | Increased IgM level (HP:0003496) | 2.12492531 |
| 79 | Abnormal platelet volume (HP:0011876) | 2.11581368 |
| 80 | Nasal polyposis (HP:0100582) | 2.11523469 |
| 81 | Microcytic anemia (HP:0001935) | 2.10716368 |
| 82 | Panhypogammaglobulinemia (HP:0003139) | 2.08234415 |
| 83 | Increased IgE level (HP:0003212) | 2.08112487 |
| 84 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 2.07893268 |
| 85 | Abnormality of the prostate (HP:0008775) | 2.07839139 |
| 86 | Lymphopenia (HP:0001888) | 2.07817628 |
| 87 | Pulmonary embolism (HP:0002204) | 2.05620058 |
| 88 | Retrobulbar optic neuritis (HP:0100654) | 2.05259742 |
| 89 | Optic neuritis (HP:0100653) | 2.05259742 |
| 90 | Encephalitis (HP:0002383) | 2.04375794 |
| 91 | Gingival bleeding (HP:0000225) | 2.03622839 |
| 92 | Ureteral obstruction (HP:0006000) | 2.02247075 |
| 93 | Systemic lupus erythematosus (HP:0002725) | 2.01148535 |
| 94 | Cholelithiasis (HP:0001081) | 1.98204697 |
| 95 | Thickened calvaria (HP:0002684) | 1.97814957 |
| 96 | Keratoconjunctivitis sicca (HP:0001097) | 1.97769116 |
| 97 | Cutaneous photosensitivity (HP:0000992) | 1.97231519 |
| 98 | Milia (HP:0001056) | 1.96992362 |
| 99 | Recurrent sinusitis (HP:0011108) | 1.95103506 |
| 100 | Alopecia of scalp (HP:0002293) | 1.94188487 |
| 101 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.93996102 |
| 102 | Slow saccadic eye movements (HP:0000514) | 1.92438058 |
| 103 | Menorrhagia (HP:0000132) | 1.90907949 |
| 104 | Abnormality of eosinophils (HP:0001879) | 1.88750674 |
| 105 | Muscle fiber splitting (HP:0003555) | 1.88638883 |
| 106 | Paralysis (HP:0003470) | 1.87264912 |
| 107 | Abnormality of the fingertips (HP:0001211) | 1.86656198 |
| 108 | Skin rash (HP:0000988) | 1.85844701 |
| 109 | Thrombophlebitis (HP:0004418) | 1.84539093 |
| 110 | Keratoconjunctivitis (HP:0001096) | 1.84180037 |
| 111 | Premature loss of primary teeth (HP:0006323) | 1.83922939 |
| 112 | Hypergammaglobulinemia (HP:0010702) | 1.83807943 |
| 113 | Abnormality of the peritoneum (HP:0002585) | 1.82824559 |
| 114 | Hepatosplenomegaly (HP:0001433) | 1.82276511 |
| 115 | Abnormality of T cell number (HP:0011839) | 1.79601440 |
| 116 | Glomerulopathy (HP:0100820) | 1.79573434 |
| 117 | Short femoral neck (HP:0100864) | 1.79018791 |
| 118 | T lymphocytopenia (HP:0005403) | 1.77793789 |
| 119 | Ectropion (HP:0000656) | 1.77461081 |
| 120 | Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108) | 1.76210192 |
| 121 | Splenomegaly (HP:0001744) | 1.76106323 |
| 122 | Reticulocytopenia (HP:0001896) | 1.74754776 |
| 123 | Right ventricular cardiomyopathy (HP:0011663) | 1.74656851 |
| 124 | Hypermelanotic macule (HP:0001034) | 1.74297256 |
| 125 | Abnormality of iron homeostasis (HP:0011031) | 1.73002940 |
| 126 | Aplastic anemia (HP:0001915) | 1.70909771 |
| 127 | Abnormal foot bone ossification (HP:0010675) | 1.70034905 |
| 128 | Pyloric stenosis (HP:0002021) | 1.69257219 |
| 129 | Pulmonary infiltrates (HP:0002113) | 1.64431025 |
| 130 | Increased serum ferritin (HP:0003281) | 1.63988079 |
| 131 | Gangrene (HP:0100758) | 1.63894993 |
| 132 | Restrictive lung disease (HP:0002091) | 1.63625597 |
| 133 | Metaphyseal irregularity (HP:0003025) | 1.63393505 |
| 134 | Increased mean platelet volume (HP:0011877) | 1.62266832 |
| 135 | Recurrent bronchitis (HP:0002837) | 1.61910695 |
| 136 | Plantar hyperkeratosis (HP:0007556) | 1.61774482 |
| 137 | Hyperactive renin-angiotensin system (HP:0000841) | 1.61736227 |
| 138 | Aplasia/hypoplasia of the femur (HP:0005613) | 1.59346304 |
| 139 | Abnormality of the pleura (HP:0002103) | 1.58628201 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRAK4 | 4.77328468 |
| 2 | MAP3K12 | 3.26918182 |
| 3 | BLK | 3.26891499 |
| 4 | EPHB1 | 2.80648331 |
| 5 | CSK | 2.79211467 |
| 6 | TRPM7 | 2.73952640 |
| 7 | PRPF4B | 2.60484546 |
| 8 | TEC | 2.51315614 |
| 9 | EPHA2 | 2.49938384 |
| 10 | STK10 | 2.40898175 |
| 11 | TESK2 | 2.33500209 |
| 12 | RIPK4 | 2.33399812 |
| 13 | BTK | 2.29450342 |
| 14 | ERBB3 | 2.29222603 |
| 15 | MAP4K1 | 2.27879886 |
| 16 | ERN1 | 2.19997460 |
| 17 | TESK1 | 2.10933285 |
| 18 | GRK6 | 2.04225587 |
| 19 | FGR | 2.02417571 |
| 20 | PAK4 | 1.97129278 |
| 21 | ZAP70 | 1.96624563 |
| 22 | MAP2K3 | 1.82183314 |
| 23 | PRKG2 | 1.76055638 |
| 24 | FES | 1.75571363 |
| 25 | KDR | 1.71572892 |
| 26 | CLK1 | 1.67720865 |
| 27 | TAOK2 | 1.63103238 |
| 28 | MAP3K6 | 1.59272947 |
| 29 | MAP2K6 | 1.56249464 |
| 30 | FRK | 1.55540054 |
| 31 | TXK | 1.55382036 |
| 32 | MST4 | 1.54096302 |
| 33 | ITK | 1.51745036 |
| 34 | PTK2 | 1.38798352 |
| 35 | HCK | 1.38270275 |
| 36 | RIPK1 | 1.34814189 |
| 37 | SIK3 | 1.33215965 |
| 38 | KSR2 | 1.29717668 |
| 39 | LRRK2 | 1.28859022 |
| 40 | TYK2 | 1.24502344 |
| 41 | MATK | 1.22463361 |
| 42 | TAOK1 | 1.13214618 |
| 43 | MAP3K11 | 1.10174352 |
| 44 | MAP3K3 | 1.08186126 |
| 45 | MARK2 | 1.05660219 |
| 46 | PTK6 | 1.03690569 |
| 47 | MAP2K4 | 1.01069341 |
| 48 | STK4 | 0.99928466 |
| 49 | IKBKE | 0.97250670 |
| 50 | IRAK3 | 0.97009390 |
| 51 | MAP3K14 | 0.96782580 |
| 52 | TBK1 | 0.95435282 |
| 53 | SIK2 | 0.93968338 |
| 54 | WEE1 | 0.93857982 |
| 55 | PTK2B | 0.93381036 |
| 56 | IRAK1 | 0.93250340 |
| 57 | CDK19 | 0.93128378 |
| 58 | TGFBR2 | 0.92230081 |
| 59 | PRKD2 | 0.92194423 |
| 60 | SMG1 | 0.87725782 |
| 61 | MAP3K5 | 0.85032216 |
| 62 | MAP3K13 | 0.82214388 |
| 63 | MST1R | 0.82136699 |
| 64 | MAP3K8 | 0.80810096 |
| 65 | PDPK1 | 0.80311686 |
| 66 | PIM1 | 0.80222738 |
| 67 | PDK1 | 0.80082364 |
| 68 | MYLK | 0.79801717 |
| 69 | LYN | 0.79376839 |
| 70 | SYK | 0.79075469 |
| 71 | NEK2 | 0.77922752 |
| 72 | MAP3K9 | 0.77013872 |
| 73 | MAPK4 | 0.74882755 |
| 74 | DAPK2 | 0.74428712 |
| 75 | IRAK2 | 0.74032210 |
| 76 | GRK1 | 0.72675821 |
| 77 | MAP2K2 | 0.72438870 |
| 78 | PIK3CG | 0.72036581 |
| 79 | LIMK1 | 0.70071253 |
| 80 | MAPK12 | 0.69314682 |
| 81 | STK11 | 0.68175498 |
| 82 | LCK | 0.67399608 |
| 83 | CSF1R | 0.66613950 |
| 84 | PRKCD | 0.64256806 |
| 85 | TAOK3 | 0.62504179 |
| 86 | RET | 0.61525633 |
| 87 | MAPKAPK2 | 0.61366558 |
| 88 | MAP3K7 | 0.58541706 |
| 89 | KIT | 0.58092666 |
| 90 | MAP3K2 | 0.55896857 |
| 91 | BRSK2 | 0.55615261 |
| 92 | MAP3K1 | 0.55232951 |
| 93 | JAK3 | 0.54577632 |
| 94 | HIPK2 | 0.53367950 |
| 95 | SIK1 | 0.52580292 |
| 96 | BUB1 | 0.50687125 |
| 97 | NLK | 0.50319655 |
| 98 | MAPK11 | 0.50012654 |
| 99 | ACVR1B | 0.45693503 |
| 100 | SGK3 | 0.45105381 |
| 101 | BMX | 0.44231237 |
| 102 | ALK | 0.43727504 |
| 103 | RAF1 | 0.43206438 |
| 104 | FYN | 0.42979670 |
| 105 | BMPR2 | 0.42618527 |
| 106 | PRKCQ | 0.42615913 |
| 107 | TTN | 0.42486347 |
| 108 | KSR1 | 0.42413699 |
| 109 | DYRK1B | 0.42146328 |
| 110 | ABL1 | 0.41020062 |
| 111 | CDK7 | 0.40121414 |
| 112 | TRIB3 | 0.40087414 |
| 113 | STK24 | 0.39416649 |
| 114 | MAPK7 | 0.38460916 |
| 115 | STK38 | 0.37664710 |
| 116 | JAK1 | 0.36929051 |
| 117 | AURKB | 0.36785397 |
| 118 | YES1 | 0.36095788 |
| 119 | PIM2 | 0.35514931 |
| 120 | RPS6KA4 | 0.34943165 |
| 121 | PRKCZ | 0.34560776 |
| 122 | RPS6KA6 | 0.33558050 |
| 123 | PKN2 | 0.33108661 |
| 124 | RPS6KL1 | 0.32879192 |
| 125 | RPS6KC1 | 0.32879192 |
| 126 | IKBKB | 0.32665784 |
| 127 | CDC42BPA | 0.32143518 |
| 128 | PIK3CA | 0.31287884 |
| 129 | DYRK3 | 0.30746396 |
| 130 | CDK9 | 0.30661709 |
| 131 | EPHA3 | 0.28941099 |
| 132 | JAK2 | 0.28916465 |
| 133 | VRK1 | 0.28855059 |
| 134 | RPS6KA2 | 0.28703836 |
| 135 | EIF2AK2 | 0.27915899 |
| 136 | TNK2 | 0.27088407 |
| 137 | MARK3 | 0.27070099 |
| 138 | CDK8 | 0.25652742 |
| 139 | RPS6KB2 | 0.24888957 |
| 140 | MELK | 0.24472985 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Leishmaniasis_Homo sapiens_hsa05140 | 3.77800694 |
| 2 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 3.06032612 |
| 3 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 2.41429964 |
| 4 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.25806032 |
| 5 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 2.21860544 |
| 6 | Shigellosis_Homo sapiens_hsa05131 | 2.17899333 |
| 7 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 2.09330406 |
| 8 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.95822902 |
| 9 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.92176721 |
| 10 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.85799351 |
| 11 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.82643853 |
| 12 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.79739957 |
| 13 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.79388944 |
| 14 | Pertussis_Homo sapiens_hsa05133 | 1.76222008 |
| 15 | Histidine metabolism_Homo sapiens_hsa00340 | 1.69933194 |
| 16 | Salmonella infection_Homo sapiens_hsa05132 | 1.67960012 |
| 17 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.67254337 |
| 18 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.60345705 |
| 19 | Other glycan degradation_Homo sapiens_hsa00511 | 1.60223270 |
| 20 | Tuberculosis_Homo sapiens_hsa05152 | 1.58901205 |
| 21 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.57544533 |
| 22 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.54823853 |
| 23 | Asthma_Homo sapiens_hsa05310 | 1.51106701 |
| 24 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.50459902 |
| 25 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.50075493 |
| 26 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.44784632 |
| 27 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.43842694 |
| 28 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.43194646 |
| 29 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.42011627 |
| 30 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.40445033 |
| 31 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.36084174 |
| 32 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.31334481 |
| 33 | DNA replication_Homo sapiens_hsa03030 | 1.31332332 |
| 34 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.27302388 |
| 35 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.27284531 |
| 36 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.23170146 |
| 37 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.22170278 |
| 38 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.18555841 |
| 39 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.18285871 |
| 40 | Measles_Homo sapiens_hsa05162 | 1.16748130 |
| 41 | Legionellosis_Homo sapiens_hsa05134 | 1.16719133 |
| 42 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.16278895 |
| 43 | Bladder cancer_Homo sapiens_hsa05219 | 1.15724520 |
| 44 | Platelet activation_Homo sapiens_hsa04611 | 1.13900634 |
| 45 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.12276347 |
| 46 | Viral myocarditis_Homo sapiens_hsa05416 | 1.11573685 |
| 47 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.09990393 |
| 48 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.08027790 |
| 49 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.03761773 |
| 50 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.02499206 |
| 51 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 1.01113991 |
| 52 | Phagosome_Homo sapiens_hsa04145 | 1.00194061 |
| 53 | Influenza A_Homo sapiens_hsa05164 | 0.99202602 |
| 54 | Hepatitis C_Homo sapiens_hsa05160 | 0.98645119 |
| 55 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.97186153 |
| 56 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.96858223 |
| 57 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.95947327 |
| 58 | Malaria_Homo sapiens_hsa05144 | 0.95306364 |
| 59 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.94955163 |
| 60 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.94717075 |
| 61 | Apoptosis_Homo sapiens_hsa04210 | 0.94681527 |
| 62 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.93353807 |
| 63 | Hepatitis B_Homo sapiens_hsa05161 | 0.92694964 |
| 64 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.92383612 |
| 65 | Adherens junction_Homo sapiens_hsa04520 | 0.91390819 |
| 66 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.91248410 |
| 67 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.90955629 |
| 68 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.86559120 |
| 69 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.84493360 |
| 70 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.83452389 |
| 71 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.83033536 |
| 72 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.82789694 |
| 73 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.82288988 |
| 74 | Lysosome_Homo sapiens_hsa04142 | 0.80503448 |
| 75 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.77466878 |
| 76 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.76698567 |
| 77 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.75828460 |
| 78 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.74752116 |
| 79 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.70843174 |
| 80 | Amoebiasis_Homo sapiens_hsa05146 | 0.70423823 |
| 81 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.70003497 |
| 82 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.69805862 |
| 83 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.69747912 |
| 84 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.69289821 |
| 85 | Base excision repair_Homo sapiens_hsa03410 | 0.67929308 |
| 86 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.67837246 |
| 87 | Endometrial cancer_Homo sapiens_hsa05213 | 0.67651208 |
| 88 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.67195287 |
| 89 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.67096138 |
| 90 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.65613591 |
| 91 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.65031230 |
| 92 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.64712967 |
| 93 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.63872062 |
| 94 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.63361333 |
| 95 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.62752398 |
| 96 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.62653988 |
| 97 | Cell cycle_Homo sapiens_hsa04110 | 0.62529460 |
| 98 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.62320620 |
| 99 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.62025288 |
| 100 | Galactose metabolism_Homo sapiens_hsa00052 | 0.61446365 |
| 101 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.60016243 |
| 102 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.57367797 |
| 103 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.56553208 |
| 104 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.53984019 |
| 105 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.51850098 |
| 106 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.51362986 |
| 107 | Insulin resistance_Homo sapiens_hsa04931 | 0.51309894 |
| 108 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.50725176 |
| 109 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.50700244 |
| 110 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.50559002 |
| 111 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.50490827 |
| 112 | Colorectal cancer_Homo sapiens_hsa05210 | 0.50333016 |
| 113 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.49650684 |
| 114 | Allograft rejection_Homo sapiens_hsa05330 | 0.49387846 |
| 115 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.48779041 |
| 116 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.48265983 |
| 117 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.47883283 |
| 118 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.47249733 |
| 119 | Mismatch repair_Homo sapiens_hsa03430 | 0.46166895 |
| 120 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.45760922 |
| 121 | HTLV-I infection_Homo sapiens_hsa05166 | 0.44771127 |
| 122 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.44607834 |
| 123 | Thyroid cancer_Homo sapiens_hsa05216 | 0.44047199 |
| 124 | Mineral absorption_Homo sapiens_hsa04978 | 0.42800643 |
| 125 | Endocytosis_Homo sapiens_hsa04144 | 0.42679154 |
| 126 | Homologous recombination_Homo sapiens_hsa03440 | 0.42266936 |
| 127 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.41247352 |
| 128 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.40700988 |
| 129 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.40334447 |
| 130 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.39436605 |
| 131 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.38193598 |

