PGLYRP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1omega-hydroxylase P450 pathway (GO:0097267)9.04509116
2exogenous drug catabolic process (GO:0042738)8.91536283
3epoxygenase P450 pathway (GO:0019373)8.89429582
4drug catabolic process (GO:0042737)8.59039792
5L-phenylalanine catabolic process (GO:0006559)7.18826885
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.18826885
7L-phenylalanine metabolic process (GO:0006558)6.91834567
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.91834567
9aromatic amino acid family catabolic process (GO:0009074)6.55880519
10drug metabolic process (GO:0017144)6.09116527
11indole-containing compound catabolic process (GO:0042436)5.99552045
12indolalkylamine catabolic process (GO:0046218)5.99552045
13tryptophan catabolic process (GO:0006569)5.99552045
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.97826258
15ethanol metabolic process (GO:0006067)5.93419483
16oxidative demethylation (GO:0070989)5.82687702
17kynurenine metabolic process (GO:0070189)5.78927254
18bile acid biosynthetic process (GO:0006699)5.77206804
19tryptophan metabolic process (GO:0006568)5.58933647
20urea cycle (GO:0000050)5.55998203
21urea metabolic process (GO:0019627)5.55998203
22glyoxylate metabolic process (GO:0046487)5.48539918
23negative regulation of fibrinolysis (GO:0051918)5.44250630
24alpha-linolenic acid metabolic process (GO:0036109)5.37411233
25high-density lipoprotein particle remodeling (GO:0034375)5.30963351
26regulation of fibrinolysis (GO:0051917)5.23748865
27complement activation, alternative pathway (GO:0006957)5.15327670
28regulation of protein activation cascade (GO:2000257)5.15279955
29nitrogen cycle metabolic process (GO:0071941)5.10519535
30sulfur amino acid catabolic process (GO:0000098)5.09689802
31peptidyl-glutamic acid carboxylation (GO:0017187)5.00103408
32protein carboxylation (GO:0018214)5.00103408
33phenylpropanoid metabolic process (GO:0009698)4.99185091
34cysteine metabolic process (GO:0006534)4.98834967
35glucuronate metabolic process (GO:0019585)4.94513738
36uronic acid metabolic process (GO:0006063)4.94513738
37negative regulation of blood coagulation (GO:0030195)4.89436743
38negative regulation of hemostasis (GO:1900047)4.89436743
39bile acid metabolic process (GO:0008206)4.84908002
40S-adenosylmethionine metabolic process (GO:0046500)4.83918371
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.83223613
42regulation of humoral immune response (GO:0002920)4.80074288
43regulation of complement activation (GO:0030449)4.79139318
44serine family amino acid catabolic process (GO:0009071)4.76573374
45regulation of triglyceride catabolic process (GO:0010896)4.75720541
46aromatic amino acid family metabolic process (GO:0009072)4.70918112
47regulation of cholesterol esterification (GO:0010872)4.69821524
48reverse cholesterol transport (GO:0043691)4.58567312
49phospholipid efflux (GO:0033700)4.50371266
50protein-lipid complex remodeling (GO:0034368)4.48908716
51macromolecular complex remodeling (GO:0034367)4.48908716
52plasma lipoprotein particle remodeling (GO:0034369)4.48908716
53tyrosine metabolic process (GO:0006570)4.46723751
54negative regulation of coagulation (GO:0050819)4.44035750
55imidazole-containing compound metabolic process (GO:0052803)4.42879982
56amino-acid betaine metabolic process (GO:0006577)4.39686694
57negative regulation of cholesterol transport (GO:0032375)4.38513222
58negative regulation of sterol transport (GO:0032372)4.38513222
59alpha-amino acid catabolic process (GO:1901606)4.35516474
60negative regulation of wound healing (GO:0061045)4.35328315
61disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.33336214
62killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.33336214
63positive regulation of blood coagulation (GO:0030194)4.31934289
64positive regulation of hemostasis (GO:1900048)4.31934289
65homocysteine metabolic process (GO:0050667)4.31838329
66acylglycerol homeostasis (GO:0055090)4.31820242
67triglyceride homeostasis (GO:0070328)4.31820242
68glycine metabolic process (GO:0006544)4.31101065
69alkaloid metabolic process (GO:0009820)4.25190913
70bile acid and bile salt transport (GO:0015721)4.24805221
71negative regulation of protein activation cascade (GO:2000258)4.22111907
72indolalkylamine metabolic process (GO:0006586)4.17249573
73amine catabolic process (GO:0009310)4.14114535
74cellular biogenic amine catabolic process (GO:0042402)4.14114535
75lysine metabolic process (GO:0006553)4.10972978
76lysine catabolic process (GO:0006554)4.10972978
77coenzyme catabolic process (GO:0009109)4.08256590
78blood coagulation, intrinsic pathway (GO:0007597)4.05109683
79arginine metabolic process (GO:0006525)4.02371275
80ethanol oxidation (GO:0006069)4.01979334
81cellular amino acid catabolic process (GO:0009063)3.98446749
82positive regulation of coagulation (GO:0050820)3.98233382
83plasma lipoprotein particle clearance (GO:0034381)3.97504327
84cellular ketone body metabolic process (GO:0046950)3.96887292
85serine family amino acid metabolic process (GO:0009069)3.96235871
86plasma lipoprotein particle assembly (GO:0034377)3.94774619
87cholesterol efflux (GO:0033344)3.93924506
88benzene-containing compound metabolic process (GO:0042537)3.89527870
89serine family amino acid biosynthetic process (GO:0009070)3.87129134
90glutamate metabolic process (GO:0006536)3.83145371
91cytolysis (GO:0019835)3.80732644
92positive regulation of fatty acid biosynthetic process (GO:0045723)3.79875147
93positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.78677692
94NAD biosynthetic process (GO:0009435)3.77855203
95cellular glucuronidation (GO:0052695)3.77642704
96fibrinolysis (GO:0042730)3.77158558
97complement activation, classical pathway (GO:0006958)3.75705887
98regulation of apoptotic cell clearance (GO:2000425)3.73241987
99protein activation cascade (GO:0072376)3.71701207
100low-density lipoprotein particle remodeling (GO:0034374)3.70346371
101cellular modified amino acid catabolic process (GO:0042219)3.70075889
102nicotinamide nucleotide biosynthetic process (GO:0019359)3.66690633
103pyridine nucleotide biosynthetic process (GO:0019363)3.66690633
104complement activation (GO:0006956)3.66374596
105positive regulation of lipoprotein lipase activity (GO:0051006)3.63776023
106positive regulation of triglyceride lipase activity (GO:0061365)3.63776023
107acute inflammatory response (GO:0002526)3.63758011
108aldehyde catabolic process (GO:0046185)3.63703566
109acute-phase response (GO:0006953)3.61108923
110dicarboxylic acid biosynthetic process (GO:0043650)3.60085229
111cofactor catabolic process (GO:0051187)3.58097155
112flavonoid metabolic process (GO:0009812)3.55137434
113cholesterol homeostasis (GO:0042632)3.53519219
114carboxylic acid catabolic process (GO:0046395)3.51731347
115organic acid catabolic process (GO:0016054)3.51731347
116intestinal cholesterol absorption (GO:0030299)3.50009568
117protein-lipid complex assembly (GO:0065005)3.49484145
118negative regulation of lipase activity (GO:0060192)3.49369084
119response to mercury ion (GO:0046689)3.48395463
120opsonization (GO:0008228)3.47281777
121regulation of lipoprotein particle clearance (GO:0010984)3.46518791
122plasma lipoprotein particle organization (GO:0071827)3.46225366
123sterol homeostasis (GO:0055092)3.45753081
124very-low-density lipoprotein particle assembly (GO:0034379)3.44892545
125phospholipid homeostasis (GO:0055091)3.42938380
126negative regulation of complement activation (GO:0045916)3.42635422
127regulation of plasminogen activation (GO:0010755)3.41993548
128ketone body metabolic process (GO:1902224)3.41563127
129hormone catabolic process (GO:0042447)3.41522364
130regulation of cholesterol homeostasis (GO:2000188)3.40921190
1312-oxoglutarate metabolic process (GO:0006103)3.39536934
132positive regulation of lipid catabolic process (GO:0050996)3.38909936
133regulation of bile acid biosynthetic process (GO:0070857)3.38867266

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.41673964
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.53381194
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.47178013
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.55088941
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.87157858
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.63811504
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.31276432
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.86432096
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.16953437
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.88630174
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.38052103
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.34500781
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.7218548
14GATA1_22025678_ChIP-Seq_K562_Human1.99431934
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83821801
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.81072994
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.80497003
18SCL_19346495_ChIP-Seq_HPC-7_Human1.78665218
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.77738357
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75919338
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69431363
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43696502
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39784023
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34717261
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.22157941
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.21430006
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19772028
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18815867
29BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18366963
30HTT_18923047_ChIP-ChIP_STHdh_Human1.16413804
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15691598
32CLOCK_20551151_ChIP-Seq_293T_Human1.14966996
33FOXA2_19822575_ChIP-Seq_HepG2_Human1.14250067
34RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13264812
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11350740
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11322827
37* HNF4A_19822575_ChIP-Seq_HepG2_Human1.10072505
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05723032
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02049916
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.01416592
41PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01412575
42GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00976869
43RUNX_20019798_ChIP-Seq_JUKART_Human1.00777498
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00187664
45NOTCH1_21737748_ChIP-Seq_TLL_Human0.99868485
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98143327
47MAF_26560356_Chip-Seq_TH1_Human0.96959030
48AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94074963
49GATA1_19941827_ChIP-Seq_MEL_Mouse0.94021584
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93398128
51MYB_26560356_Chip-Seq_TH1_Human0.92897030
52MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91779509
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91765672
54MYC_22102868_ChIP-Seq_BL_Human0.91571607
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90716211
56RAC3_21632823_ChIP-Seq_H3396_Human0.90504965
57BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90273461
58* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89119838
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.88556223
60ESR1_21235772_ChIP-Seq_MCF-7_Human0.88552644
61SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.88159668
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87959759
63TRIM28_21343339_ChIP-Seq_HEK293_Human0.87956725
64ELF1_20517297_ChIP-Seq_JURKAT_Human0.87592928
65IRF8_27001747_Chip-Seq_BMDM_Mouse0.84890304
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84846347
67IRF8_21731497_ChIP-ChIP_J774_Mouse0.84285936
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.84074731
69GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83402151
70BP1_19119308_ChIP-ChIP_Hs578T_Human0.82656214
71E2F1_20622854_ChIP-Seq_HELA_Human0.82231370
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.81868867
73ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80994486
74SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80715424
75UTX_26944678_Chip-Seq_JUKART_Human0.80510722
76SOX2_21211035_ChIP-Seq_LN229_Human0.79803790
77SPI1_20517297_ChIP-Seq_HL60_Human0.78513081
78DNAJC2_21179169_ChIP-ChIP_NT2_Human0.77488270
79STAT3_1855785_ChIP-Seq_MESCs_Mouse0.76804388
80PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76585492
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.76525999
82MYB_26560356_Chip-Seq_TH2_Human0.76340740
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76293746
84RARB_24833708_ChIP-Seq_LIVER_Mouse0.74305669
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74096115
86CTCF_27219007_Chip-Seq_Bcells_Human0.73156504
87LXR_22292898_ChIP-Seq_THP-1_Human0.73070087
88BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72753128
89SMC4_20622854_ChIP-Seq_HELA_Human0.72583369
90P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.71838389
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71521015
92IRF1_19129219_ChIP-ChIP_H3396_Human0.71333378
93RUNX1_22412390_ChIP-Seq_EML_Mouse0.70203822
94ERG_21242973_ChIP-ChIP_JURKAT_Human0.70086663
95P53_21459846_ChIP-Seq_SAOS-2_Human0.69794193
96TAF2_19829295_ChIP-Seq_ESCs_Human0.69645557
97RARG_19884340_ChIP-ChIP_MEFs_Mouse0.69565953
98VDR_21846776_ChIP-Seq_THP-1_Human0.69051260
99SOX2_27498859_Chip-Seq_STOMACH_Mouse0.69034981
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.68851814
101SA1_27219007_Chip-Seq_Bcells_Human0.68137069
102MAF_26560356_Chip-Seq_TH2_Human0.67873173
103GATA1_19941826_ChIP-Seq_K562_Human0.67811035
104KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67609732
105RARA_24833708_ChIP-Seq_LIVER_Mouse0.67593433
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.67525878
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.67414790
108CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.67099804
109CBP_21632823_ChIP-Seq_H3396_Human0.66444147
110ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.66283433
111Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66274747
112CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.66113429
113RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65953788
114TCF7_22412390_ChIP-Seq_EML_Mouse0.65658806
115CTCF_20526341_ChIP-Seq_ESCs_Human0.65537236
116BCL6_27268052_Chip-Seq_Bcells_Human0.65485244
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.64126621
118MYC_19829295_ChIP-Seq_ESCs_Human0.63350708
119GATA2_19941826_ChIP-Seq_K562_Human0.63009361
120ZNF263_19887448_ChIP-Seq_K562_Human0.62885892
121GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.62874915
122CEBPB_22108803_ChIP-Seq_LS180_Human0.62389650
123* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.62366060
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62085573
125AUTS2_25519132_ChIP-Seq_293T-REX_Human0.61414206
126SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.61412398
127ETV2_25802403_ChIP-Seq_MESCs_Mouse0.61294598
128GATA4_25053715_ChIP-Seq_YYC3_Human0.61073734
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.60778433
130CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.60625805
131ERG_20887958_ChIP-Seq_HPC-7_Mouse0.60424384
132* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.60308231
133ERG_20517297_ChIP-Seq_VCAP_Human0.60022839
134* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.59115940
135TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.58810161
136HNFA_21074721_ChIP-Seq_CACO-2_Human0.58591038
137* AR_20517297_ChIP-Seq_VCAP_Human0.58506426
138BCAT_22108803_ChIP-Seq_LS180_Human0.57733808
139BCOR_27268052_Chip-Seq_Bcells_Human0.57129577
140POU5F1_16518401_ChIP-PET_MESCs_Mouse0.57118695
141CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.57032966
142TET1_21451524_ChIP-Seq_MESCs_Mouse0.56633499
143FOXA1_25552417_ChIP-Seq_VCAP_Human0.56442405
144GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.56414298
145CDX2_20551321_ChIP-Seq_CACO-2_Human0.56193430
146EGR1_19032775_ChIP-ChIP_M12_Human0.56167527
147GATA6_21074721_ChIP-Seq_CACO-2_Human0.55754660
148P68_20966046_ChIP-Seq_HELA_Human0.55467954
149ER_23166858_ChIP-Seq_MCF-7_Human0.55388647
150ERA_21632823_ChIP-Seq_H3396_Human0.55065226
151P300_27268052_Chip-Seq_Bcells_Human0.54927282
152SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.54152653
153PHF8_20622854_ChIP-Seq_HELA_Human0.53824000
154SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.53288673
155PHF8_20622853_ChIP-Seq_HELA_Human0.53170832
156OCT4_20526341_ChIP-Seq_ESCs_Human0.51532684

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.35574900
2MP0005360_urolithiasis6.79817948
3MP0005085_abnormal_gallbladder_physiolo5.88980297
4MP0005365_abnormal_bile_salt5.75169256
5MP0008875_abnormal_xenobiotic_pharmacok4.58406678
6MP0003806_abnormal_nucleotide_metabolis3.78423346
7MP0003252_abnormal_bile_duct3.55152933
8MP0010329_abnormal_lipoprotein_level3.29346717
9MP0009840_abnormal_foam_cell3.13183184
10MP0005083_abnormal_biliary_tract2.71653337
11MP0003191_abnormal_cellular_cholesterol2.54434244
12MP0001666_abnormal_nutrient_absorption2.46552930
13MP0005332_abnormal_amino_acid2.46501018
14MP0003195_calcinosis2.25608351
15MP0000609_abnormal_liver_physiology2.18043404
16MP0003868_abnormal_feces_composition2.04574647
17MP0002138_abnormal_hepatobiliary_system2.03831570
18MP0002118_abnormal_lipid_homeostasis1.89792854
19MP0004019_abnormal_vitamin_homeostasis1.80722605
20MP0005319_abnormal_enzyme/_coenzyme1.79895310
21MP0001764_abnormal_homeostasis1.75625480
22MP0005584_abnormal_enzyme/coenzyme_acti1.56011161
23MP0000685_abnormal_immune_system1.55507036
24MP0002254_reproductive_system_inflammat1.46547762
25MP0009697_abnormal_copulation1.44655214
26MP0005464_abnormal_platelet_physiology1.38297014
27MP0001661_extended_life_span1.35162723
28MP0003656_abnormal_erythrocyte_physiolo1.33444046
29MP0003011_delayed_dark_adaptation1.32632912
30MP0000598_abnormal_liver_morphology1.29738611
31MP0001835_abnormal_antigen_presentation1.26977586
32* MP0008469_abnormal_protein_level1.26947033
33MP0003724_increased_susceptibility_to1.25304344
34MP0009643_abnormal_urine_homeostasis1.24963605
35MP0003186_abnormal_redox_activity1.24404769
36MP0009763_increased_sensitivity_to1.24082978
37MP0009764_decreased_sensitivity_to1.22624915
38MP0005451_abnormal_body_composition1.18687956
39MP0003436_decreased_susceptibility_to1.17537406
40MP0005647_abnormal_sex_gland1.13812252
41MP0010368_abnormal_lymphatic_system1.12463770
42* MP0009785_altered_susceptibility_to1.10938149
43MP0005671_abnormal_response_to1.08775324
44MP0009053_abnormal_anal_canal1.04784020
45MP0009765_abnormal_xenobiotic_induced1.04611889
46MP0006082_CNS_inflammation0.99348591
47MP0003763_abnormal_thymus_physiology0.99137649
48* MP0005025_abnormal_response_to0.98239453
49MP0008872_abnormal_physiological_respon0.96910481
50MP0001800_abnormal_humoral_immune0.95261372
51MP0001853_heart_inflammation0.93693760
52MP0002282_abnormal_trachea_morphology0.92674354
53* MP0009642_abnormal_blood_homeostasis0.92096594
54MP0005636_abnormal_mineral_homeostasis0.91003087
55MP0005075_abnormal_melanosome_morpholog0.90088133
56MP0006036_abnormal_mitochondrial_physio0.89864492
57MP0000604_amyloidosis0.88117947
58MP0003879_abnormal_hair_cell0.86539206
59MP0001845_abnormal_inflammatory_respons0.85037145
60MP0002249_abnormal_larynx_morphology0.84729803
61MP0002876_abnormal_thyroid_physiology0.84416653
62MP0001873_stomach_inflammation0.84398330
63MP0005395_other_phenotype0.82889648
64MP0001790_abnormal_immune_system0.82318495
65MP0005387_immune_system_phenotype0.82318495
66MP0004782_abnormal_surfactant_physiolog0.81293389
67MP0010155_abnormal_intestine_physiology0.77126294
68MP0005220_abnormal_exocrine_pancreas0.75128425
69* MP0002723_abnormal_immune_serum0.73557160
70MP0002166_altered_tumor_susceptibility0.72577676
71MP0005376_homeostasis/metabolism_phenot0.72273768
72MP0002168_other_aberrant_phenotype0.71996272
73MP0004381_abnormal_hair_follicle0.71423322
74MP0000566_synostosis0.71290866
75* MP0002419_abnormal_innate_immunity0.69494516
76MP0004947_skin_inflammation0.69327082
77MP0005084_abnormal_gallbladder_morpholo0.68211218
78MP0000689_abnormal_spleen_morphology0.67787463
79MP0005670_abnormal_white_adipose0.67598628
80MP0005334_abnormal_fat_pad0.67166121
81MP0002078_abnormal_glucose_homeostasis0.66172787
82MP0005408_hypopigmentation0.66121952
83MP0003300_gastrointestinal_ulcer0.63948067
84MP0002971_abnormal_brown_adipose0.62474683
85MP0003075_altered_response_to0.62191088
86MP0001915_intracranial_hemorrhage0.61835568
87MP0003690_abnormal_glial_cell0.61239927
88MP0005000_abnormal_immune_tolerance0.60222673
89MP0003705_abnormal_hypodermis_morpholog0.59931435
90MP0002132_abnormal_respiratory_system0.59277850
91MP0002722_abnormal_immune_system0.58932184
92MP0003638_abnormal_response/metabolism_0.58726324
93MP0002396_abnormal_hematopoietic_system0.58384232
94MP0000716_abnormal_immune_system0.58040410
95* MP0002452_abnormal_antigen_presenting0.58006484
96MP0008873_increased_physiological_sensi0.56558484
97MP0002398_abnormal_bone_marrow0.55992509
98MP0002136_abnormal_kidney_physiology0.55518256
99MP0000639_abnormal_adrenal_gland0.55318617
100MP0004130_abnormal_muscle_cell0.55317617
101* MP0002420_abnormal_adaptive_immunity0.54918960
102* MP0001819_abnormal_immune_cell0.54079367
103MP0001545_abnormal_hematopoietic_system0.53818534
104MP0005397_hematopoietic_system_phenotyp0.53818534
105MP0005535_abnormal_body_temperature0.53360799
106MP0004883_abnormal_blood_vessel0.52433426
107MP0002928_abnormal_bile_duct0.51137975
108MP0002429_abnormal_blood_cell0.51080786
109MP0006035_abnormal_mitochondrial_morpho0.51035729
110MP0005266_abnormal_metabolism0.51003668
111MP0000249_abnormal_blood_vessel0.49999024
112MP0000465_gastrointestinal_hemorrhage0.49022666
113MP0005166_decreased_susceptibility_to0.48870014
114MP0009379_abnormal_foot_pigmentation0.48728848
115MP0005058_abnormal_lysosome_morphology0.48313864
116MP0008874_decreased_physiological_sensi0.46197835
117MP0005187_abnormal_penis_morphology0.45713799
118MP0003718_maternal_effect0.44641010
119MP0000467_abnormal_esophagus_morphology0.43848576
120MP0005023_abnormal_wound_healing0.43414116
121MP0005164_abnormal_response_to0.42536555
122MP0005448_abnormal_energy_balance0.41797278
123MP0003329_amyloid_beta_deposits0.39197624
124MP0009333_abnormal_splenocyte_physiolog0.36767049
125MP0005646_abnormal_pituitary_gland0.36696371
126MP0001881_abnormal_mammary_gland0.34389506
127MP0003878_abnormal_ear_physiology0.30456342
128MP0005377_hearing/vestibular/ear_phenot0.30456342
129MP0003953_abnormal_hormone_level0.27720570
130MP0009115_abnormal_fat_cell0.27078449
131MP0001851_eye_inflammation0.25792795
132MP0001986_abnormal_taste_sensitivity0.25582021
133MP0002332_abnormal_exercise_endurance0.25412965

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.17306941
2Deep venous thrombosis (HP:0002625)6.82249922
3Intrahepatic cholestasis (HP:0001406)6.71241930
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.30237036
5Prolonged partial thromboplastin time (HP:0003645)6.29894391
6Hypobetalipoproteinemia (HP:0003563)6.07864479
7Xanthomatosis (HP:0000991)5.73490277
8Hyperlipoproteinemia (HP:0010980)5.37259609
9Complement deficiency (HP:0004431)4.97917645
10Joint hemorrhage (HP:0005261)4.75384830
11Hyperammonemia (HP:0001987)4.39140309
12Hypolipoproteinemia (HP:0010981)4.38065277
13Abnormality of the common coagulation pathway (HP:0010990)4.35136334
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.09095010
15Epidermoid cyst (HP:0200040)4.00982733
16Nephritis (HP:0000123)3.99563273
17Abnormality of methionine metabolism (HP:0010901)3.98592329
18Fat malabsorption (HP:0002630)3.88028942
19Abnormality of sulfur amino acid metabolism (HP:0004339)3.84773281
20Abnormality of glutamine family amino acid metabolism (HP:0010902)3.84724487
21Ketosis (HP:0001946)3.83849202
22Abnormality of aspartate family amino acid metabolism (HP:0010899)3.82980419
23Hyperglycinemia (HP:0002154)3.78436250
24Abnormality of pyrimidine metabolism (HP:0004353)3.74421308
25Hypoalphalipoproteinemia (HP:0003233)3.67856778
26Abnormality of the intrinsic pathway (HP:0010989)3.64646426
27Abnormality of complement system (HP:0005339)3.56778785
28Hypercholesterolemia (HP:0003124)3.42876141
29Conjugated hyperbilirubinemia (HP:0002908)3.42538955
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.40012297
31Spontaneous abortion (HP:0005268)3.34243814
32Abnormality of glycine metabolism (HP:0010895)3.33961203
33Abnormality of serine family amino acid metabolism (HP:0010894)3.33961203
34Hyperglycinuria (HP:0003108)3.33478806
35Hyperbilirubinemia (HP:0002904)3.32818954
36Hypoglycemic coma (HP:0001325)3.29208180
37Abnormality of fatty-acid metabolism (HP:0004359)3.21350352
38Gingival bleeding (HP:0000225)3.09223207
39Steatorrhea (HP:0002570)3.02331241
40Delayed CNS myelination (HP:0002188)2.86627050
41Abnormality of serum amino acid levels (HP:0003112)2.85717261
42Abnormality of nucleobase metabolism (HP:0010932)2.85568685
43Hepatocellular carcinoma (HP:0001402)2.76543747
44Neonatal hypoglycemia (HP:0001998)2.75088814
45Acanthocytosis (HP:0001927)2.73155481
46Recurrent gram-negative bacterial infections (HP:0005420)2.69500866
47Hypochromic microcytic anemia (HP:0004840)2.69018870
48Myocardial infarction (HP:0001658)2.65519349
49Menorrhagia (HP:0000132)2.64170368
50Fair hair (HP:0002286)2.63677087
51Metabolic acidosis (HP:0001942)2.58571059
52Thrombophlebitis (HP:0004418)2.54167306
53Systemic lupus erythematosus (HP:0002725)2.49709175
54Rickets (HP:0002748)2.48888400
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.46831986
56Dicarboxylic aciduria (HP:0003215)2.46831986
57Ketoacidosis (HP:0001993)2.44623489
58Spastic diplegia (HP:0001264)2.42740742
59Epistaxis (HP:0000421)2.42081257
60Abnormality of purine metabolism (HP:0004352)2.41142374
61Lethargy (HP:0001254)2.34442259
62Neonatal onset (HP:0003623)2.24923321
63Skin nodule (HP:0200036)2.23558395
64Mitral stenosis (HP:0001718)2.22377998
65Pulmonary embolism (HP:0002204)2.22231192
66Amyloidosis (HP:0011034)2.21540509
67Esophageal varix (HP:0002040)2.19415746
68Abnormal gallbladder morphology (HP:0012437)2.18716369
69Pancreatitis (HP:0001733)2.18031847
70Vascular calcification (HP:0004934)2.16749257
71Glomerulonephritis (HP:0000099)2.16615016
72Gangrene (HP:0100758)2.15869115
73Cholelithiasis (HP:0001081)2.14942695
74Joint swelling (HP:0001386)2.14016517
75Poikilocytosis (HP:0004447)2.13612706
76Irritability (HP:0000737)2.12888385
77Osteomalacia (HP:0002749)2.12154964
78Generalized aminoaciduria (HP:0002909)2.07876474
79Cerebral edema (HP:0002181)2.06363616
80Microcytic anemia (HP:0001935)2.04817510
81Elevated hepatic transaminases (HP:0002910)2.04203312
82Gout (HP:0001997)2.04108396
83Abnormality of iron homeostasis (HP:0011031)2.03725475
84Purpura (HP:0000979)2.01355759
85Late onset (HP:0003584)2.01010133
86Brushfield spots (HP:0001088)1.98479961
87Renal cortical cysts (HP:0000803)1.98177662
88Hypoglycemic seizures (HP:0002173)1.97933288
89Generalized hypopigmentation of hair (HP:0011358)1.97004942
90Cholecystitis (HP:0001082)1.94191829
91Abnormal gallbladder physiology (HP:0012438)1.94191829
92Abnormality of transition element cation homeostasis (HP:0011030)1.92801980
93Opisthotonus (HP:0002179)1.92374862
94Abnormal platelet volume (HP:0011876)1.91463570
95Hemorrhage of the eye (HP:0011885)1.90638615
96Increased mean platelet volume (HP:0011877)1.90229322
97Malnutrition (HP:0004395)1.89299980
98Hypoplasia of the thymus (HP:0000778)1.86686966
99Cardiovascular calcification (HP:0011915)1.86188633
100Hypertriglyceridemia (HP:0002155)1.84657846
101Vomiting (HP:0002013)1.83283444
102Abnormal platelet function (HP:0011869)1.82623523
103Impaired platelet aggregation (HP:0003540)1.82623523
104Sensorimotor neuropathy (HP:0007141)1.82087676
105Hypophosphatemic rickets (HP:0004912)1.82069588
106Enlarged kidneys (HP:0000105)1.80878214
107Abnormality of the Achilles tendon (HP:0005109)1.80376878
108Hyperphosphaturia (HP:0003109)1.80304660
109Increased serum ferritin (HP:0003281)1.78342595
110Abnormality of the gallbladder (HP:0005264)1.77536105
111Cerebral palsy (HP:0100021)1.75685461
112Bifid scrotum (HP:0000048)1.72526252
113Abnormality of proline metabolism (HP:0010907)1.71480945
114Hydroxyprolinuria (HP:0003080)1.71480945
115Hypochromic anemia (HP:0001931)1.66435215
116Abnormality of vitamin metabolism (HP:0100508)1.66418038
117Reduced antithrombin III activity (HP:0001976)1.65846955
118Reticulocytosis (HP:0001923)1.65118011
119Elevated alkaline phosphatase (HP:0003155)1.65007848
120Arthropathy (HP:0003040)1.64665716
121Abnormal enzyme/coenzyme activity (HP:0012379)1.64522396
122Atrioventricular block (HP:0001678)1.56282564
123Blue irides (HP:0000635)1.55156000
124Abnormality of alkaline phosphatase activity (HP:0004379)1.55145182
125Glycosuria (HP:0003076)1.54560382
126Abnormality of urine glucose concentration (HP:0011016)1.54560382

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.36659279
2FGFR44.36795614
3ERN13.63286809
4MAP4K13.24683998
5SIK12.90371273
6FLT32.87178149
7TAOK32.49387364
8TYK22.44968564
9TXK2.30273244
10PIK3CA2.19571282
11TBK12.10038362
12PKN22.07224930
13KIT2.07067838
14IKBKE2.06881093
15KDR1.94718854
16JAK31.93052059
17RIPK11.81427200
18ZAP701.79331313
19MAPK111.74217133
20GRK61.71806792
21MAP3K141.67096274
22PRPF4B1.63197277
23PIK3CG1.62438770
24BTK1.59717733
25MAP2K31.59530282
26JAK11.52696992
27CSF1R1.47463438
28SCYL21.46316641
29NME21.44135344
30NLK1.42739984
31TRIB31.39573444
32TIE11.39359196
33EEF2K1.36722600
34ERBB41.35727434
35TEC1.34993682
36TGFBR21.29071492
37SMG11.27638505
38TGFBR11.27025677
39JAK21.23878513
40MAP3K101.23810984
41INSRR1.22641426
42ITK1.18248276
43MAP3K71.16161354
44PTK61.13982171
45TAOK21.12015112
46NTRK31.08396830
47MUSK1.08117514
48FGFR31.04730492
49SYK1.04556393
50MAP2K61.03752556
51NEK91.01343457
52PRKCG0.98315398
53MAP2K40.98001754
54PDPK10.95136587
55MAP3K130.95102695
56EPHA30.94476296
57STK160.90546391
58EPHB10.90200454
59MAPK40.89900727
60IKBKB0.89579608
61LCK0.88651940
62CSK0.87157650
63MAP2K20.86681952
64MAP3K110.84725647
65IRAK40.79452214
66ACVR1B0.79239622
67FER0.78414748
68IRAK30.73400684
69PRKAA20.73209621
70PRKCZ0.72483580
71MAPK120.71055860
72RET0.70420051
73LRRK20.70234717
74DYRK1B0.69416803
75LYN0.68153311
76PRKACA0.66385305
77MST1R0.66225994
78PRKCQ0.66106689
79CDK60.65358301
80BLK0.63520035
81GRK10.61799209
82STK100.59706332
83PRKG10.58952438
84CDK40.58926993
85CSNK1D0.57584327
86HCK0.56841325
87RPS6KB20.55533833
88ADRBK20.55354296
89TRPM70.55252952
90CHUK0.54952388
91PINK10.53606079
92TESK20.53042150
93ABL20.51997470
94EPHA20.51195047
95PRKCA0.50953915
96PIM10.50152093
97ERBB20.48958787
98IRAK10.48022638
99TNK20.46951180
100PRKAA10.45469483
101PIM20.43666661
102DYRK30.42273809
103MAPK150.42156081
104FRK0.42037594
105SRC0.41515471
106IGF1R0.40812457
107MAPKAPK50.39936628
108CSNK2A10.39330422
109MAPK70.38667258
110MAPKAPK30.38403038
111RPS6KA40.38056702
112RPS6KB10.37992238
113PDK20.36700862
114PRKCB0.36107311
115CAMKK10.36074052
116RPS6KA30.36065387
117MAP3K30.35804286
118MATK0.35674909
119DYRK1A0.35474171
120ICK0.35243954
121PDK10.34892407
122PRKACG0.34623863
123MAPK30.34197371
124PRKG20.33863018
125EIF2AK30.33047544
126MTOR0.32749919
127CSNK2A20.31831721
128NEK60.31201903
129CSNK1G10.30508816
130FGFR20.30465302
131MYLK0.26247265
132DAPK20.24978602
133MAP3K10.24190742
134EGFR0.23625076
135ABL10.23288227
136PRKCH0.23251537
137MAP3K120.22654715
138FES0.22421396
139CAMK2G0.21331228

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.70546652
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.47635954
3Nitrogen metabolism_Homo sapiens_hsa009103.45562279
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34322447
5Arginine biosynthesis_Homo sapiens_hsa002203.03756464
6Complement and coagulation cascades_Homo sapiens_hsa046102.88901291
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66293181
8Tryptophan metabolism_Homo sapiens_hsa003802.61389760
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.47959552
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.46422763
11Fatty acid degradation_Homo sapiens_hsa000712.44921057
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30527341
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.26134588
14Peroxisome_Homo sapiens_hsa041462.08670278
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99320543
16Staphylococcus aureus infection_Homo sapiens_hsa051501.96268986
17Caffeine metabolism_Homo sapiens_hsa002321.93185396
18Histidine metabolism_Homo sapiens_hsa003401.91223780
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.90568781
20Chemical carcinogenesis_Homo sapiens_hsa052041.89473846
21Butanoate metabolism_Homo sapiens_hsa006501.83158785
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.81838609
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.81154363
24PPAR signaling pathway_Homo sapiens_hsa033201.79079724
25Propanoate metabolism_Homo sapiens_hsa006401.75754168
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.71661759
27Fatty acid metabolism_Homo sapiens_hsa012121.67375286
28Selenocompound metabolism_Homo sapiens_hsa004501.65952806
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62609160
30beta-Alanine metabolism_Homo sapiens_hsa004101.61883009
31Retinol metabolism_Homo sapiens_hsa008301.59734484
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58311369
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.43586377
34Phenylalanine metabolism_Homo sapiens_hsa003601.43238021
35Folate biosynthesis_Homo sapiens_hsa007901.37888092
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36660905
37Bile secretion_Homo sapiens_hsa049761.32996783
38ABC transporters_Homo sapiens_hsa020101.30434012
39Tyrosine metabolism_Homo sapiens_hsa003501.30389161
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26973686
41Fatty acid elongation_Homo sapiens_hsa000621.26295324
42Pyruvate metabolism_Homo sapiens_hsa006201.26216782
43Biosynthesis of amino acids_Homo sapiens_hsa012301.20780025
44Starch and sucrose metabolism_Homo sapiens_hsa005001.18889771
45Sulfur relay system_Homo sapiens_hsa041221.18520093
46Arachidonic acid metabolism_Homo sapiens_hsa005901.17761957
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.10823611
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09794122
49Sulfur metabolism_Homo sapiens_hsa009201.09348536
50Fat digestion and absorption_Homo sapiens_hsa049751.03965339
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03683353
52Carbon metabolism_Homo sapiens_hsa012001.02625792
53Steroid biosynthesis_Homo sapiens_hsa001000.96932738
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95498886
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.94612325
56Vitamin digestion and absorption_Homo sapiens_hsa049770.84468792
57One carbon pool by folate_Homo sapiens_hsa006700.83477362
58Arginine and proline metabolism_Homo sapiens_hsa003300.78543778
59Pentose phosphate pathway_Homo sapiens_hsa000300.74018839
60Vitamin B6 metabolism_Homo sapiens_hsa007500.70680173
61Lysine degradation_Homo sapiens_hsa003100.70308935
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61321201
63Glycerolipid metabolism_Homo sapiens_hsa005610.59526532
64Primary immunodeficiency_Homo sapiens_hsa053400.58976431
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57369457
66Glutathione metabolism_Homo sapiens_hsa004800.53938675
67Pertussis_Homo sapiens_hsa051330.44542802
68Metabolic pathways_Homo sapiens_hsa011000.43323482
69Fatty acid biosynthesis_Homo sapiens_hsa000610.31295658
70Galactose metabolism_Homo sapiens_hsa000520.30229733
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27512383
72Systemic lupus erythematosus_Homo sapiens_hsa053220.25612424
73Prion diseases_Homo sapiens_hsa050200.24465089
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.24277516
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24006159
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23844235
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.23133788
78Fructose and mannose metabolism_Homo sapiens_hsa000510.22989704
79Insulin resistance_Homo sapiens_hsa049310.22358681
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19690577
81Other glycan degradation_Homo sapiens_hsa005110.17475802
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.16464771
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14070544
84Linoleic acid metabolism_Homo sapiens_hsa005910.12976540
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.08410394
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.07522800
87Measles_Homo sapiens_hsa051620.06566674
88Antigen processing and presentation_Homo sapiens_hsa046120.05500759
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.04231983
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.02411463
91Amoebiasis_Homo sapiens_hsa051460.00890273
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.00030140
93Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2832939
94Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.2788528
95Autoimmune thyroid disease_Homo sapiens_hsa05320-0.2607137
96Circadian rhythm_Homo sapiens_hsa04710-0.2473678
97Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2239928
98Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1927676
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1925218
100Sphingolipid metabolism_Homo sapiens_hsa00600-0.1902183
101Insulin signaling pathway_Homo sapiens_hsa04910-0.1459769
102Renin-angiotensin system_Homo sapiens_hsa04614-0.1162047
103Mineral absorption_Homo sapiens_hsa04978-0.0975757
104Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0887791
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650-0.0827771
106Serotonergic synapse_Homo sapiens_hsa04726-0.0757692
107Leishmaniasis_Homo sapiens_hsa05140-0.0742771
108T cell receptor signaling pathway_Homo sapiens_hsa04660-0.0708949
109Hematopoietic cell lineage_Homo sapiens_hsa04640-0.0695920
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0639577
111B cell receptor signaling pathway_Homo sapiens_hsa04662-0.0570007
112Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0569671
113Acute myeloid leukemia_Homo sapiens_hsa05221-0.0561151
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0529192
115AMPK signaling pathway_Homo sapiens_hsa04152-0.0492088
116Pyrimidine metabolism_Homo sapiens_hsa00240-0.0361265
117Allograft rejection_Homo sapiens_hsa05330-0.0236479
118Hepatitis C_Homo sapiens_hsa05160-0.0146803
119African trypanosomiasis_Homo sapiens_hsa05143-0.0116809
120Glucagon signaling pathway_Homo sapiens_hsa04922-0.0011724

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