PGLYRP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1long-chain fatty acid biosynthetic process (GO:0042759)8.95986418
2keratinization (GO:0031424)8.94677148
3endocrine hormone secretion (GO:0060986)8.41912287
4multicellular organismal water homeostasis (GO:0050891)7.61497706
5lipoxygenase pathway (GO:0019372)7.52239916
6hemidesmosome assembly (GO:0031581)7.39996393
7linoleic acid metabolic process (GO:0043651)7.31921578
8desmosome organization (GO:0002934)7.22693975
9regulation of transforming growth factor beta1 production (GO:0032908)6.71682789
10mitotic sister chromatid cohesion (GO:0007064)6.26983536
11regulation of cardioblast proliferation (GO:0003264)6.13693912
12regulation of secondary heart field cardioblast proliferation (GO:0003266)6.13693912
13water homeostasis (GO:0030104)6.08924983
14molting cycle (GO:0042303)5.85179799
15hair cycle (GO:0042633)5.85179799
16keratinocyte differentiation (GO:0030216)5.65358545
17mating behavior (GO:0007617)5.60251461
18intermediate filament cytoskeleton organization (GO:0045104)5.56974725
19thyroid gland development (GO:0030878)5.53796318
20phosphatidylethanolamine acyl-chain remodeling (GO:0036152)5.48875685
21intermediate filament-based process (GO:0045103)5.38870934
22thyroid hormone generation (GO:0006590)5.33488600
23gap junction assembly (GO:0016264)5.31471403
24establishment of planar polarity (GO:0001736)4.98864727
25establishment of tissue polarity (GO:0007164)4.98864727
26phosphatidylcholine acyl-chain remodeling (GO:0036151)4.87002184
27skin morphogenesis (GO:0043589)4.85503543
28ganglion development (GO:0061548)4.56095879
29peptide cross-linking (GO:0018149)4.50462944
30epidermal cell differentiation (GO:0009913)4.45667235
31positive regulation of monocyte chemotaxis (GO:0090026)4.42366777
32ectoderm development (GO:0007398)4.40135826
33positive regulation of glomerulus development (GO:0090193)4.39448554
34thyroid hormone metabolic process (GO:0042403)4.17590859
35embryonic foregut morphogenesis (GO:0048617)4.17390454
36receptor guanylyl cyclase signaling pathway (GO:0007168)4.16227586
37keratinocyte development (GO:0003334)4.14657983
38surfactant homeostasis (GO:0043129)4.11496039
39* detection of bacterium (GO:0016045)4.08947547
40epithelium development (GO:0060429)4.06532349
41sequestering of metal ion (GO:0051238)3.99484028
42negative regulation of interleukin-17 production (GO:0032700)3.97342655
43keratinocyte proliferation (GO:0043616)3.93452045
44mesodermal cell differentiation (GO:0048333)3.90297668
45* negative regulation of interferon-gamma production (GO:0032689)3.84838137
46SMAD protein complex assembly (GO:0007183)3.80282486
47regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.76031462
48ceramide biosynthetic process (GO:0046513)3.73401325
49regulation of transforming growth factor beta2 production (GO:0032909)3.72997996
50mitotic chromosome condensation (GO:0007076)3.71976388
51* detection of other organism (GO:0098543)3.67925748
52polarized epithelial cell differentiation (GO:0030859)3.67437719
53negative regulation of organ growth (GO:0046621)3.66275118
54regulation of T cell chemotaxis (GO:0010819)3.62790357
55positive regulation of T cell chemotaxis (GO:0010820)3.62790357
56positive regulation of male gonad development (GO:2000020)3.60063895
57bundle of His cell to Purkinje myocyte communication (GO:0086069)3.60017660
58retina vasculature morphogenesis in camera-type eye (GO:0061299)3.58737868
59positive regulation of epidermis development (GO:0045684)3.57957669
60hair follicle morphogenesis (GO:0031069)3.57589683
61interferon-gamma secretion (GO:0072643)3.57119578
62cell adhesion mediated by integrin (GO:0033627)3.56524910
63negative regulation of keratinocyte proliferation (GO:0010839)3.54818852
64chemical homeostasis within a tissue (GO:0048875)3.54045271
65hippo signaling (GO:0035329)3.51227760
66phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.47604591
67lateral sprouting from an epithelium (GO:0060601)3.47193883
68regulation of transforming growth factor beta production (GO:0071634)3.47003950
69substrate-dependent cell migration (GO:0006929)3.46491802
70planar cell polarity pathway involved in neural tube closure (GO:0090179)3.42730745
71alditol phosphate metabolic process (GO:0052646)3.42001429
72phospholipid catabolic process (GO:0009395)3.40392265
73positive regulation of epidermal cell differentiation (GO:0045606)3.36625947
74regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.36387847
75negative regulation of axon extension involved in axon guidance (GO:0048843)3.35660934
76regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.34170240
77regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.26426406
78eyelid development in camera-type eye (GO:0061029)3.26391647
79nephron tubule formation (GO:0072079)3.24649127
80regulation of cell proliferation involved in kidney development (GO:1901722)3.23355550
81epithelial cell differentiation involved in prostate gland development (GO:0060742)3.22999221
82regulation of monocyte chemotaxis (GO:0090025)3.20965829
83positive regulation of transforming growth factor beta production (GO:0071636)3.18462440
84sister chromatid segregation (GO:0000819)3.17103498
85phosphatidylserine acyl-chain remodeling (GO:0036150)3.14910204
86positive regulation of interleukin-8 secretion (GO:2000484)3.13730401
87hepatocyte differentiation (GO:0070365)3.13605081
88ventricular cardiac muscle cell action potential (GO:0086005)3.11715395
89hypotonic response (GO:0006971)3.11653834
90regulation of male gonad development (GO:2000018)3.10764675
91phosphatidylinositol acyl-chain remodeling (GO:0036149)3.08816235
92regulation of keratinocyte differentiation (GO:0045616)3.05396541
93regulation of keratinocyte proliferation (GO:0010837)3.04399762
94notochord development (GO:0030903)3.03246379
95anatomical structure arrangement (GO:0048532)3.03242211
96glial cell proliferation (GO:0014009)3.00772123
97epidermis development (GO:0008544)2.98052014
98myoblast migration (GO:0051451)2.96981472
99metanephric mesenchyme development (GO:0072075)2.96934398
100epithelial cell differentiation (GO:0030855)2.93572960
101* regulation of natural killer cell differentiation (GO:0032823)2.93355817
102hepatocyte apoptotic process (GO:0097284)2.93101584
103phosphatidylglycerol metabolic process (GO:0046471)2.90515761
104fatty acid elongation (GO:0030497)2.90437194
105positive regulation of positive chemotaxis (GO:0050927)2.90364502
106cellular response to arsenic-containing substance (GO:0071243)2.89851712
107regulation of epidermis development (GO:0045682)2.87903199
108defense response to fungus (GO:0050832)2.87478973
109regulation of heart rate by cardiac conduction (GO:0086091)2.85583751
110facial nerve structural organization (GO:0021612)2.83766911
111G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.83221510
112cytoskeletal anchoring at plasma membrane (GO:0007016)2.82963232
113atrioventricular valve morphogenesis (GO:0003181)2.81506541
114pharyngeal system development (GO:0060037)2.78422701
115lung epithelium development (GO:0060428)2.77340560
116intermediate filament organization (GO:0045109)2.74262002
117regulation of positive chemotaxis (GO:0050926)2.72474879
118regulation of heart morphogenesis (GO:2000826)2.69920498
119protein localization to microtubule (GO:0035372)2.67802264
120regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.66488926
121positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.66012485
122axon extension involved in axon guidance (GO:0048846)2.65299695
123neuron projection extension involved in neuron projection guidance (GO:1902284)2.65299695
124positive regulation of collagen biosynthetic process (GO:0032967)2.64276421
125phospholipid efflux (GO:0033700)2.64004984
126lens fiber cell development (GO:0070307)2.63598585
127negative regulation of histone methylation (GO:0031061)2.63332763
128nodal signaling pathway (GO:0038092)2.63286082
129cell-substrate junction assembly (GO:0007044)2.61399619
130regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.60822549
131positive regulation of keratinocyte differentiation (GO:0045618)2.60449291
132regulation of DNA endoreduplication (GO:0032875)2.59407091
133hair cycle process (GO:0022405)2.58414054
134molting cycle process (GO:0022404)2.58414054
135positive regulation of cholesterol efflux (GO:0010875)2.57868561
136negative regulation of axon guidance (GO:1902668)2.57557730
137dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.57223558
138kidney mesenchyme development (GO:0072074)2.56300182
139cranial nerve morphogenesis (GO:0021602)2.56251700
140apical protein localization (GO:0045176)2.54690559
141macroautophagy (GO:0016236)2.54546691
142cranial nerve structural organization (GO:0021604)2.53377022
143respiratory tube development (GO:0030323)2.53305081
144skin development (GO:0043588)2.53212211
145regulation of neuron projection regeneration (GO:0070570)2.53141158
146regulation of axon regeneration (GO:0048679)2.53141158
147phosphatidylserine metabolic process (GO:0006658)2.52613966
148cardiac right ventricle morphogenesis (GO:0003215)2.51880087
149positive regulation of protein localization to plasma membrane (GO:1903078)2.51023361
150regulation of epidermal cell differentiation (GO:0045604)2.50180253
151tachykinin receptor signaling pathway (GO:0007217)2.48508667
152sphingolipid biosynthetic process (GO:0030148)2.43031570
153positive regulation of granulocyte chemotaxis (GO:0071624)2.41748541
154phosphatidic acid biosynthetic process (GO:0006654)2.39266212
155phosphatidic acid metabolic process (GO:0046473)2.39266212
156unsaturated fatty acid biosynthetic process (GO:0006636)2.37290604
157cell communication involved in cardiac conduction (GO:0086065)2.34477582
158regulation of interleukin-17 production (GO:0032660)2.33289347
159regulation of ruffle assembly (GO:1900027)2.32112647
160response to phenylpropanoid (GO:0080184)2.31535801
161intestinal epithelial cell development (GO:0060576)2.30658461
162regulation of cholesterol homeostasis (GO:2000188)2.30090920
163epithelial cell-cell adhesion (GO:0090136)2.30024338
164regulation of hair cycle (GO:0042634)2.26975637
165regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.26464042
166cardiac conduction (GO:0061337)2.26003278
167negative regulation of epidermis development (GO:0045683)2.23948894
168positive regulation of cholesterol transport (GO:0032376)2.21051168
169positive regulation of sterol transport (GO:0032373)2.21051168
170response to UV-B (GO:0010224)2.18373726
171defense response to Gram-negative bacterium (GO:0050829)2.17290306
172negative regulation of cell fate specification (GO:0009996)2.16197288
173antimicrobial humoral response (GO:0019730)2.14667669
174establishment of skin barrier (GO:0061436)13.9955161
175regulation of water loss via skin (GO:0033561)12.1211711

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.31490136
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.00786117
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.00268658
4E2F7_22180533_ChIP-Seq_HELA_Human3.97130338
5ZNF263_19887448_ChIP-Seq_K562_Human3.74205247
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.41965152
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.91833446
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.80591934
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.78803323
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.66098539
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.58672790
12FOXO3_23340844_ChIP-Seq_DLD1_Human2.41284739
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.30102437
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.30102437
15TP53_16413492_ChIP-PET_HCT116_Human2.29933793
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05884615
17P63_26484246_Chip-Seq_KERATINOCYTES_Human2.04662505
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.02193160
19TP63_17297297_ChIP-ChIP_HaCaT_Human10.6632619
20CLOCK_20551151_ChIP-Seq_293T_Human1.99155744
21HIF1A_21447827_ChIP-Seq_MCF-7_Human1.98908027
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.97984115
23* TP63_22573176_ChIP-Seq_HFKS_Human1.93822107
24CJUN_26792858_Chip-Seq_BT549_Human1.87388748
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.77424482
26* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.74820364
27SALL4_18804426_ChIP-ChIP_XEN_Mouse1.74584079
28SOX9_24532713_ChIP-Seq_HFSC_Mouse1.74008689
29TP53_18474530_ChIP-ChIP_U2OS_Human1.72070112
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66166229
31SOX2_20726797_ChIP-Seq_SW620_Human1.61475326
32FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.56729869
33TP63_23658742_ChIP-Seq_EP156T_Human1.54740811
34AR_21909140_ChIP-Seq_LNCAP_Human1.53789918
35BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.52216719
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51623017
37* GATA6_21074721_ChIP-Seq_CACO-2_Human1.47728486
38CTCF_27219007_Chip-Seq_Bcells_Human1.45683938
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43431838
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.41129446
41VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.38997467
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38661649
43ERG_20517297_ChIP-Seq_VCAP_Human1.38598682
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35831871
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34122851
46RACK7_27058665_Chip-Seq_MCF-7_Human1.32260631
47GATA4_25053715_ChIP-Seq_YYC3_Human1.32150019
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.31691057
49ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.31500656
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26423620
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25339896
52SMC4_20622854_ChIP-Seq_HELA_Human1.24757073
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23305187
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20776116
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18953782
56ATF3_27146783_Chip-Seq_COLON_Human1.18481346
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17711295
58* E2F1_20622854_ChIP-Seq_HELA_Human1.17539831
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16994265
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14939221
61RXR_22108803_ChIP-Seq_LS180_Human1.14531850
62SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13862644
63BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.12591469
64UBF1/2_26484160_Chip-Seq_HMECs_Human1.12067671
65* CTCF_20526341_ChIP-Seq_ESCs_Human1.10998381
66GATA6_25053715_ChIP-Seq_YYC3_Human1.10152299
67GATA3_24758297_ChIP-Seq_MCF-7_Human1.08199589
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08151821
69* BCOR_27268052_Chip-Seq_Bcells_Human1.07517773
70PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07347932
71FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06744729
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06256986
73P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.05696061
74TCF4_18268006_ChIP-ChIP_LS174T_Human1.03826385
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03244414
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03244414
77EWS_26573619_Chip-Seq_HEK293_Human1.02988536
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02234470
79FOXA1_25552417_ChIP-Seq_VCAP_Human1.02054292
80FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99501502
81KLF5_25053715_ChIP-Seq_YYC3_Human0.99080041
82LXR_22292898_ChIP-Seq_THP-1_Human0.98900218
83JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98870011
84JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98390300
85RUNX1_27514584_Chip-Seq_MCF-7_Human0.97555061
86TAF15_26573619_Chip-Seq_HEK293_Human0.96327175
87AHR_22903824_ChIP-Seq_MCF-7_Human0.94940025
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93102998
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90001356
90* SA1_27219007_Chip-Seq_ERYTHROID_Human0.89933878
91CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89514729
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89355760
93RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89301031
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87487218
95AR_21572438_ChIP-Seq_LNCaP_Human0.86598748
96PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86418280
97BRD4_25478319_ChIP-Seq_HGPS_Human0.85694433
98YY1_22570637_ChIP-Seq_MALME-3M_Human0.84979471
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83798518
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83328831
101EGR1_19032775_ChIP-ChIP_M12_Human0.83207236
102CHD1_26751641_Chip-Seq_LNCaP_Human0.81972502
103PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80965475
104ELK3_25401928_ChIP-Seq_HUVEC_Human0.80846287
105GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.80798026
106KLF5_20875108_ChIP-Seq_MESCs_Mouse0.79974123
107* RBPJ_21746931_ChIP-Seq_IB4_Human0.78957987
108GATA1_19941826_ChIP-Seq_K562_Human0.78726286
109BCL6_27268052_Chip-Seq_Bcells_Human0.78566389
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78161029
111P300_27268052_Chip-Seq_Bcells_Human0.78130693
112STAT6_21828071_ChIP-Seq_BEAS2B_Human0.77522697
113EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.77415265
114HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.77253814
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.77230458
116E2F4_17652178_ChIP-ChIP_JURKAT_Human0.77197028
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.76991030
118FUS_26573619_Chip-Seq_HEK293_Human0.76965714
119* P53_21459846_ChIP-Seq_SAOS-2_Human0.76438047
120FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.76315647
121IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.75702006
122* TAF2_19829295_ChIP-Seq_ESCs_Human0.75466726
123CTCF_18555785_Chip-Seq_ESCs_Mouse0.75338326
124* P68_20966046_ChIP-Seq_HELA_Human0.75189091
125RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.75096529
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74366969
127ERG_21242973_ChIP-ChIP_JURKAT_Human0.73548998
128KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.72925540
129SA1_27219007_Chip-Seq_Bcells_Human0.71294626
130SMAD4_21741376_ChIP-Seq_ESCs_Human0.71177558
131* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.70730582
132* HNFA_21074721_ChIP-Seq_CACO-2_Human0.70504940
133ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.70420621
134CEBPB_22108803_ChIP-Seq_LS180_Human0.69629759
135RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.69579644
136FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69287679
137GATA2_19941826_ChIP-Seq_K562_Human0.69191839
138SRY_22984422_ChIP-ChIP_TESTIS_Rat0.68919322
139SUZ12_27294783_Chip-Seq_ESCs_Mouse0.68831002
140ISL1_27105846_Chip-Seq_CPCs_Mouse0.68623126
141PPARA_22158963_ChIP-Seq_LIVER_Mouse0.68613052
142AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67748670
143ARNT_22903824_ChIP-Seq_MCF-7_Human0.67087387
144RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.66797380
145KDM2B_26808549_Chip-Seq_K562_Human0.66729268
146CTBP1_25329375_ChIP-Seq_LNCAP_Human0.66630668
147TP53_20018659_ChIP-ChIP_R1E_Mouse0.66348918
148JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.66060339
149SMAD1_18555785_Chip-Seq_ESCs_Mouse0.65616923
150SPI1_20517297_ChIP-Seq_HL60_Human0.64873642
151TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.64471266

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.76609196
2MP0010234_abnormal_vibrissa_follicle6.64970550
3MP0005501_abnormal_skin_physiology4.25155914
4MP0005275_abnormal_skin_tensile3.93506347
5MP0003941_abnormal_skin_development3.67985635
6MP0005187_abnormal_penis_morphology3.58276196
7MP0003315_abnormal_perineum_morphology3.33899320
8MP0002876_abnormal_thyroid_physiology3.31474324
9MP0010678_abnormal_skin_adnexa3.26117963
10MP0004947_skin_inflammation2.99460968
11MP0005451_abnormal_body_composition2.89722194
12MP0000647_abnormal_sebaceous_gland2.81223493
13MP0003453_abnormal_keratinocyte_physiol2.73088320
14MP0003878_abnormal_ear_physiology2.70112772
15MP0005377_hearing/vestibular/ear_phenot2.70112772
16MP0004885_abnormal_endolymph2.70033442
17MP0001216_abnormal_epidermal_layer2.69350274
18MP0000579_abnormal_nail_morphology2.68745576
19MP0000467_abnormal_esophagus_morphology2.48608470
20MP0001346_abnormal_lacrimal_gland2.37056444
21MP0000383_abnormal_hair_follicle2.36905356
22MP0003705_abnormal_hypodermis_morpholog2.36661149
23MP0010771_integument_phenotype2.36544897
24MP0002060_abnormal_skin_morphology2.30070291
25MP0000566_synostosis2.27742360
26MP0010030_abnormal_orbit_morphology2.14045015
27MP0000427_abnormal_hair_cycle2.09701601
28MP0004185_abnormal_adipocyte_glucose2.01502276
29MP0000681_abnormal_thyroid_gland2.01037428
30MP0004381_abnormal_hair_follicle2.00544568
31MP0002009_preneoplasia1.93494505
32MP0000537_abnormal_urethra_morphology1.77639390
33MP0005409_darkened_coat_color1.75161038
34MP0003300_gastrointestinal_ulcer1.73109715
35MP0002098_abnormal_vibrissa_morphology1.70307589
36MP0003191_abnormal_cellular_cholesterol1.63062565
37MP0002254_reproductive_system_inflammat1.59593565
38MP0002095_abnormal_skin_pigmentation1.58546245
39MP0003950_abnormal_plasma_membrane1.52391440
40MP0009931_abnormal_skin_appearance1.49054222
41MP0000377_abnormal_hair_follicle1.46130873
42MP0000762_abnormal_tongue_morphology1.44253997
43MP0009379_abnormal_foot_pigmentation1.42166005
44MP0004782_abnormal_surfactant_physiolog1.40025087
45MP0010352_gastrointestinal_tract_polyps1.38742799
46MP0001191_abnormal_skin_condition1.36858474
47MP0003566_abnormal_cell_adhesion1.36397893
48MP0002234_abnormal_pharynx_morphology1.33359379
49MP0008789_abnormal_olfactory_epithelium1.30814910
50MP0003011_delayed_dark_adaptation1.25874703
51MP0000631_abnormal_neuroendocrine_gland1.11916921
52MP0001849_ear_inflammation1.08096375
53MP0003890_abnormal_embryonic-extraembry1.03404515
54MP0005076_abnormal_cell_differentiation1.02847728
55MP0004043_abnormal_pH_regulation0.99993232
56MP0005023_abnormal_wound_healing0.98796109
57MP0002177_abnormal_outer_ear0.96282704
58MP0008961_abnormal_basal_metabolism0.93138253
59MP0003091_abnormal_cell_migration0.89000094
60MP0005666_abnormal_adipose_tissue0.86163849
61MP0001299_abnormal_eye_distance/0.85040886
62MP0004197_abnormal_fetal_growth/weight/0.84959781
63MP0002090_abnormal_vision0.81704739
64MP0002166_altered_tumor_susceptibility0.78672506
65MP0004272_abnormal_basement_membrane0.75548946
66MP0009780_abnormal_chondrocyte_physiolo0.74765574
67MP0010307_abnormal_tumor_latency0.74322882
68MP0001340_abnormal_eyelid_morphology0.72332145
69MP0004858_abnormal_nervous_system0.72067752
70MP0000367_abnormal_coat/_hair0.71300777
71MP0003937_abnormal_limbs/digits/tail_de0.71273268
72MP0001243_abnormal_dermal_layer0.70701123
73MP0002277_abnormal_respiratory_mucosa0.68941402
74MP0002006_tumorigenesis0.68817705
75MP0001851_eye_inflammation0.67566551
76MP0001188_hyperpigmentation0.66855526
77MP0000432_abnormal_head_morphology0.66554828
78MP0003329_amyloid_beta_deposits0.63522319
79MP0005375_adipose_tissue_phenotype0.62689898
80MP0000627_abnormal_mammary_gland0.62491394
81MP0001784_abnormal_fluid_regulation0.62229554
82MP0002084_abnormal_developmental_patter0.61983801
83MP0002896_abnormal_bone_mineralization0.61428247
84MP0000534_abnormal_ureter_morphology0.60679020
85MP0003755_abnormal_palate_morphology0.59817442
86MP0004264_abnormal_extraembryonic_tissu0.59293932
87MP0000733_abnormal_muscle_development0.56197408
88MP0003690_abnormal_glial_cell0.55861093
89MP0009703_decreased_birth_body0.55085574
90MP0002697_abnormal_eye_size0.54733637
91MP0000015_abnormal_ear_pigmentation0.54611813
92MP0001502_abnormal_circadian_rhythm0.52268461
93MP0009053_abnormal_anal_canal0.52134169
94MP0005623_abnormal_meninges_morphology0.52007304
95MP0000685_abnormal_immune_system0.51343729
96MP0001485_abnormal_pinna_reflex0.50357475
97MP0003935_abnormal_craniofacial_develop0.49612136
98MP0008004_abnormal_stomach_pH0.49337631
99MP0000013_abnormal_adipose_tissue0.48644528
100MP0003045_fibrosis0.48066653
101MP0003763_abnormal_thymus_physiology0.47812091
102MP0003638_abnormal_response/metabolism_0.47450555
103MP0002877_abnormal_melanocyte_morpholog0.47368118
104MP0002233_abnormal_nose_morphology0.46375181
105MP0001177_atelectasis0.46312777
106MP0004147_increased_porphyrin_level0.45409387
107MP0009384_cardiac_valve_regurgitation0.43442460
108MP0003942_abnormal_urinary_system0.42866107
109MP0003938_abnormal_ear_development0.42774490
110MP0003567_abnormal_fetal_cardiomyocyte0.41210254
111MP0002282_abnormal_trachea_morphology0.40517903
112MP0002111_abnormal_tail_morphology0.40284944
113MP0005174_abnormal_tail_pigmentation0.38964095
114MP0000465_gastrointestinal_hemorrhage0.37807849
115MP0009250_abnormal_appendicular_skeleto0.36882239
116MP0005075_abnormal_melanosome_morpholog0.34444249
117MP0009333_abnormal_splenocyte_physiolog0.30002922
118MP0000470_abnormal_stomach_morphology0.29697396
119MP0002133_abnormal_respiratory_system0.24244125
120MP0005388_respiratory_system_phenotype0.24244125
121MP0004019_abnormal_vitamin_homeostasis0.23127862
122MP0005499_abnormal_olfactory_system0.22683678
123MP0005394_taste/olfaction_phenotype0.22683678
124MP0001186_pigmentation_phenotype0.18066875
125MP0005503_abnormal_tendon_morphology0.15883982
126MP0002138_abnormal_hepatobiliary_system0.15262681
127MP0000858_altered_metastatic_potential0.14501562
128MP0001765_abnormal_ion_homeostasis0.13567614
129MP0008569_lethality_at_weaning0.12695583
130MP0008260_abnormal_autophagy0.10138084
131MP0005387_immune_system_phenotype0.08191771
132MP0001790_abnormal_immune_system0.08191771
133MP0005193_abnormal_anterior_eye0.08166372
134MP0001958_emphysema0.08054655
135MP0009840_abnormal_foam_cell0.07838051
136MP0000371_diluted_coat_color0.05693768
137MP0003436_decreased_susceptibility_to0.05079403
138MP0002075_abnormal_coat/hair_pigmentati0.04886979
139MP0003448_altered_tumor_morphology0.04631243

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)7.54553353
2Lip pit (HP:0100267)7.25512681
3Congenital ichthyosiform erythroderma (HP:0007431)6.09068008
4Abnormality of the axillary hair (HP:0100134)5.37557613
5Abnormality of secondary sexual hair (HP:0009888)5.37557613
6Onycholysis (HP:0001806)5.18368050
7Gangrene (HP:0100758)4.93996775
8Plantar hyperkeratosis (HP:0007556)4.89706864
9Milia (HP:0001056)4.84074329
10Fragile nails (HP:0001808)4.70827563
11Increased IgE level (HP:0003212)4.54373869
12Ectropion (HP:0000656)4.26787689
13Right ventricular cardiomyopathy (HP:0011663)4.18030861
14Palmoplantar hyperkeratosis (HP:0000972)4.15869146
15Thick nail (HP:0001805)3.95943166
16Palmar hyperkeratosis (HP:0010765)3.92985573
17Hypotrichosis (HP:0001006)3.89006786
18Ankyloglossia (HP:0010296)3.87590613
19Nail dystrophy (HP:0008404)3.72724276
20Absent eyelashes (HP:0000561)3.71167032
21Sparse eyelashes (HP:0000653)3.64892250
22Eczematoid dermatitis (HP:0000976)3.55186795
23Erythroderma (HP:0001019)3.48774566
24Hyporeflexia of lower limbs (HP:0002600)3.36478324
25Volvulus (HP:0002580)3.30750509
26Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.30271072
27Lack of skin elasticity (HP:0100679)3.28495418
28Abnormal blistering of the skin (HP:0008066)3.26579391
29Absent hair (HP:0002298)3.25159289
30Parakeratosis (HP:0001036)3.22811254
31Corneal erosion (HP:0200020)3.19592100
32Pustule (HP:0200039)3.19397656
33Follicular hyperkeratosis (HP:0007502)3.18675573
34Woolly hair (HP:0002224)3.11419189
35Abnormal hair laboratory examination (HP:0003328)3.10726079
36Furrowed tongue (HP:0000221)3.06965102
37Pili torti (HP:0003777)2.97071927
38Macroorchidism (HP:0000053)2.96169182
39Sparse scalp hair (HP:0002209)2.91514780
40Curly hair (HP:0002212)2.91137317
41Alopecia of scalp (HP:0002293)2.87735200
42Sensory axonal neuropathy (HP:0003390)2.87192372
43Atrophic scars (HP:0001075)2.85659323
44Abnormality of oral frenula (HP:0000190)2.84399062
45Amniotic constriction ring (HP:0009775)2.81052207
46Abnormality of placental membranes (HP:0011409)2.81052207
47Natal tooth (HP:0000695)2.79053523
48Ridged nail (HP:0001807)2.78946141
49Hypohidrosis (HP:0000966)2.78651270
50Palmoplantar keratoderma (HP:0000982)2.75463127
51Abnormality of the nasal septum (HP:0000419)2.75120263
52Erythema (HP:0010783)2.73124741
53Rectal prolapse (HP:0002035)2.65429932
54Advanced eruption of teeth (HP:0006288)2.56742371
55Skin pits (HP:0100276)2.54746576
56Recurrent corneal erosions (HP:0000495)2.54525427
57Stenosis of the external auditory canal (HP:0000402)2.53453378
58Hemorrhage of the eye (HP:0011885)2.40414473
59Brittle hair (HP:0002299)2.38360921
60Blepharitis (HP:0000498)2.35520089
61Subcapsular cataract (HP:0000523)2.35280233
62Abnormality of the gastric mucosa (HP:0004295)2.34717887
63Cupped ear (HP:0000378)2.33421596
64Pruritus (HP:0000989)2.26047762
65Autoamputation (HP:0001218)2.25574408
66Abnormality of the labia majora (HP:0012881)2.23548931
67Increased number of teeth (HP:0011069)2.19371564
68Abnormality of hair growth rate (HP:0011363)2.19070952
69Slow-growing hair (HP:0002217)2.19070952
70Focal segmental glomerulosclerosis (HP:0000097)2.18643436
71Laryngomalacia (HP:0001601)2.16967035
72Hypergammaglobulinemia (HP:0010702)2.15707755
73Biliary tract neoplasm (HP:0100574)2.13374410
74Preauricular pit (HP:0004467)2.12486628
75Periauricular skin pits (HP:0100277)2.12486628
76Hamartoma of the eye (HP:0010568)2.10645261
77Primary amenorrhea (HP:0000786)2.08921641
78Arterial tortuosity (HP:0005116)2.07730126
79Multifactorial inheritance (HP:0001426)2.07465550
80Oral leukoplakia (HP:0002745)2.06997929
81Dehydration (HP:0001944)2.03456593
82Coronal craniosynostosis (HP:0004440)2.00977338
83Abnormality of the salivary glands (HP:0010286)1.97615435
84Melanocytic nevus (HP:0000995)1.96022637
85Premature ovarian failure (HP:0008209)1.95431713
86Urticaria (HP:0001025)1.95336488
87Lymphangioma (HP:0100764)1.94473982
88Paralysis (HP:0003470)1.94228602
89Hypogonadotrophic hypogonadism (HP:0000044)1.89920975
90Bronchomalacia (HP:0002780)1.89068788
91Pigmentary retinal degeneration (HP:0001146)1.84020145
92Glomerulosclerosis (HP:0000096)1.82309256
93Conjunctival hamartoma (HP:0100780)1.81825938
94Heterotopia (HP:0002282)1.80911455
95Anonychia (HP:0001798)1.80286814
96Conjunctival telangiectasia (HP:0000524)1.79453697
97Dry skin (HP:0000958)1.78878550
98Selective tooth agenesis (HP:0001592)1.77352074
99Interstitial pulmonary disease (HP:0006530)1.76466733
100Micronodular cirrhosis (HP:0001413)1.75802816
101Vascular tortuosity (HP:0004948)1.75565103
102Tapered finger (HP:0001182)1.75437791
103Osteolytic defects of the phalanges of the hand (HP:0009771)1.74770810
104Osteolytic defects of the hand bones (HP:0009699)1.74770810
105Increased nuchal translucency (HP:0010880)1.73047095
106Back pain (HP:0003418)1.72760360
107Skin ulcer (HP:0200042)1.72324808
108Xerostomia (HP:0000217)1.72011491
109Sepsis (HP:0100806)1.71010115
110Malignant hyperthermia (HP:0002047)1.70711241
111Breast hypoplasia (HP:0003187)1.70623401
112Hypercortisolism (HP:0001578)1.69402004
113Split foot (HP:0001839)1.69358323
114Hypoplasia of dental enamel (HP:0006297)1.69118554
115Fine hair (HP:0002213)1.67425559
116Aortic aneurysm (HP:0004942)1.66809928
117Increased neuronal autofluorescent lipopigment (HP:0002074)1.66762935
118Carious teeth (HP:0000670)1.66289898
119Hypoplastic labia majora (HP:0000059)1.64940694
120Corneal dystrophy (HP:0001131)1.63946922
121Severe Myopia (HP:0011003)1.63853547
122Hyperhidrosis (HP:0000975)1.62740742
123Keratoconjunctivitis sicca (HP:0001097)1.62132810
124Polar cataract (HP:0010696)1.60981959
125Nasolacrimal duct obstruction (HP:0000579)1.59648339
126Ventricular tachycardia (HP:0004756)1.59504911
127Conical tooth (HP:0000698)1.57834891
128Popliteal pterygium (HP:0009756)1.57626776
129Abnormality of the fingernails (HP:0001231)1.56844731
130Papilloma (HP:0012740)1.56530297
131Verrucae (HP:0200043)1.56530297
132Hypochromic microcytic anemia (HP:0004840)1.55460504
133Abnormality of the frontal sinuses (HP:0002687)1.54413107
134Oligodontia (HP:0000677)1.53664656
135Keratoconjunctivitis (HP:0001096)1.53533569
136Hypodontia (HP:0000668)1.52604819
137Acanthosis nigricans (HP:0000956)1.51645532
138Deviation of the thumb (HP:0009603)1.51631928
139Testicular neoplasm (HP:0010788)1.50875561
140Obsessive-compulsive behavior (HP:0000722)1.50401997
141Labial hypoplasia (HP:0000066)1.49523957
142Duplicated collecting system (HP:0000081)1.48234894
143Hypoplastic toenails (HP:0001800)1.43981165
144Abnormality of permanent molar morphology (HP:0011071)1.41636735
145Abnormality of the dental root (HP:0006486)1.41636735
146Taurodontia (HP:0000679)1.41636735
147Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.40779559
148Dry hair (HP:0011359)1.40649613
149Squamous cell carcinoma (HP:0002860)1.39615635
150Hamartoma (HP:0010566)1.38444359
151Septate vagina (HP:0001153)1.37727517
152Hypoplastic female external genitalia (HP:0012815)1.35890635

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.04851852
2INSRR4.77270118
3ACVR1B4.76685167
4MAP3K63.79360701
5TRPM73.47230141
6MAP3K22.89879408
7YES12.82061123
8MELK2.79152259
9RIPK12.38704212
10CDK62.33115199
11FGFR12.32123373
12EPHA32.25280976
13ERBB32.17307696
14FER2.10966714
15DYRK1B2.07171822
16BMPR1B2.06932557
17LATS12.04262492
18SGK4941.94511563
19SGK2231.94511563
20MAP3K121.87167696
21NEK91.84954584
22PAK31.67828016
23EEF2K1.66485369
24MST1R1.66371703
25GRK61.65492582
26RPS6KB21.64269611
27MST41.63465062
28EPHB11.59347779
29SCYL21.56684672
30CDK121.55904223
31MAP3K71.55736651
32MAP3K91.53612384
33IRAK11.39914111
34MAP2K11.39261990
35TGFBR11.38964189
36KSR21.31157691
37TRIB31.30321780
38GRK51.30302794
39BCR1.29243036
40IKBKB1.28082419
41SIK11.27635393
42STK101.26252841
43FGFR21.23345250
44AURKB1.22084192
45PTK21.20224017
46UHMK11.16010984
47MAP3K31.13120324
48STK31.12680527
49CDC71.09240505
50CAMK1D1.07219924
51FGFR41.06750674
52PKN21.02917173
53TESK11.02492349
54MAPKAPK31.02098222
55MAPK71.00074271
56MAPKAPK50.93342150
57MARK20.91662371
58TAOK10.90361180
59LRRK20.89412535
60MAP2K40.87020475
61PRPF4B0.86609102
62PRKD20.85672542
63FRK0.82832418
64CDK40.82073843
65SMG10.81404556
66JAK30.80896757
67BRD40.79643494
68PTK60.78659399
69CDK80.75854020
70EPHB20.75702671
71EPHA40.73417489
72MAPKAPK20.71686588
73FGFR30.69974441
74NEK10.69172132
75CAMK1G0.69110922
76TTN0.69027720
77ERN10.68799386
78BRSK20.68275314
79WNK10.68141293
80PIM20.67387931
81STK240.67387779
82PBK0.64288283
83NLK0.64224940
84BRSK10.60833165
85MAP2K20.58476833
86SRPK10.57978017
87PRKAA20.57157354
88MAP3K10.57080276
89CSK0.56774404
90MAPK150.56206836
91KSR10.55431197
92PDGFRA0.55178265
93PIK3CG0.54114120
94RET0.52475719
95RPS6KB10.52102630
96RIPK40.51837010
97BLK0.51718291
98HIPK20.51545063
99LIMK10.51373575
100MTOR0.50905682
101IRAK30.50119016
102KIT0.49924961
103ERBB40.49724429
104FGR0.48221896
105MET0.48141865
106CSNK1D0.47934948
107GSK3A0.46676196
108WNK30.44773527
109MAP2K30.44756779
110IKBKE0.44489350
111DYRK30.44259716
112NEK20.43633750
113PAK40.43051112
114MAP3K80.42782087
115STK380.42614201
116MAPK120.41783085
117MAP3K140.41516565
118SGK10.40944514
119NME10.40055804
120CAMKK20.39436074
121CDC42BPA0.37773278
122ATM0.36683036
123CHUK0.35827730
124MAP3K50.35275243
125PNCK0.35249571
126EGFR0.34948582
127BMX0.34827909
128MAP3K130.34416874
129SGK30.33805172
130ABL10.33264046
131ADRBK10.32155521
132SGK20.29434056
133PLK30.27655864
134PDGFRB0.27385311
135IRAK20.26271879
136CHEK10.26163361
137STK38L0.25565224
138CAMK2B0.23795250
139IRAK40.23605127
140MAP3K110.23570151
141MAP2K60.22291664
142CSNK1A1L0.21884581
143TYRO30.21714955
144MAPK90.21306223
145CDK10.21205565
146DMPK0.20996892
147LATS20.20934844
148HCK0.19177987
149PAK20.19088992
150CSNK1E0.18266446
151AURKA0.17915590
152PRKDC0.17860569
153TBK10.16842518
154FLT30.16368986
155PRKD30.15665829
156MAPK40.15538799
157RPS6KA20.14982191

Predicted pathways (KEGG)

RankGene SetZ-score
1GnRH signaling pathway_Homo sapiens_hsa049123.24821585
2Autoimmune thyroid disease_Homo sapiens_hsa053203.13133939
3Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.06005192
4Ovarian steroidogenesis_Homo sapiens_hsa049132.87329916
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.82630669
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.63015155
7Adherens junction_Homo sapiens_hsa045202.52987257
8Linoleic acid metabolism_Homo sapiens_hsa005912.42906661
9Small cell lung cancer_Homo sapiens_hsa052222.21863881
10Phototransduction_Homo sapiens_hsa047442.10900512
11Tight junction_Homo sapiens_hsa045301.94696697
12Sphingolipid metabolism_Homo sapiens_hsa006001.89947841
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.81814117
14Ether lipid metabolism_Homo sapiens_hsa005651.79390969
15Histidine metabolism_Homo sapiens_hsa003401.76853872
16Vascular smooth muscle contraction_Homo sapiens_hsa042701.73584442
17VEGF signaling pathway_Homo sapiens_hsa043701.72119902
18Glycerophospholipid metabolism_Homo sapiens_hsa005641.66263401
19Hippo signaling pathway_Homo sapiens_hsa043901.60419267
20Proteoglycans in cancer_Homo sapiens_hsa052051.59027716
21ECM-receptor interaction_Homo sapiens_hsa045121.56094070
22p53 signaling pathway_Homo sapiens_hsa041151.51506488
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.50590555
24Pancreatic cancer_Homo sapiens_hsa052121.42698096
25ErbB signaling pathway_Homo sapiens_hsa040121.41556961
26Adipocytokine signaling pathway_Homo sapiens_hsa049201.40036892
27Prolactin signaling pathway_Homo sapiens_hsa049171.39315072
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.38744775
29Dorso-ventral axis formation_Homo sapiens_hsa043201.35637878
30Type II diabetes mellitus_Homo sapiens_hsa049301.33848891
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27391593
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25214163
33Bladder cancer_Homo sapiens_hsa052191.24145573
34Staphylococcus aureus infection_Homo sapiens_hsa051501.21893980
35Colorectal cancer_Homo sapiens_hsa052101.21853493
36MicroRNAs in cancer_Homo sapiens_hsa052061.21838764
37Toxoplasmosis_Homo sapiens_hsa051451.20102566
38FoxO signaling pathway_Homo sapiens_hsa040681.18539204
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.18494708
40Chronic myeloid leukemia_Homo sapiens_hsa052201.18150200
41Focal adhesion_Homo sapiens_hsa045101.10785918
42Thyroid hormone synthesis_Homo sapiens_hsa049181.08607405
43Amoebiasis_Homo sapiens_hsa051461.08540767
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08512151
45Basal cell carcinoma_Homo sapiens_hsa052171.07774617
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02537038
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01406898
48Renin secretion_Homo sapiens_hsa049241.00944095
49Cell cycle_Homo sapiens_hsa041101.00800595
50Acute myeloid leukemia_Homo sapiens_hsa052211.00670232
51Fat digestion and absorption_Homo sapiens_hsa049751.00232861
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99985880
53mTOR signaling pathway_Homo sapiens_hsa041500.98725338
54Arachidonic acid metabolism_Homo sapiens_hsa005900.98022872
55Hepatitis C_Homo sapiens_hsa051600.97262178
56TGF-beta signaling pathway_Homo sapiens_hsa043500.96727772
57TNF signaling pathway_Homo sapiens_hsa046680.96067223
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95300291
59Axon guidance_Homo sapiens_hsa043600.90392823
60Hematopoietic cell lineage_Homo sapiens_hsa046400.87755729
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84891202
62Long-term depression_Homo sapiens_hsa047300.84547368
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84392524
64Wnt signaling pathway_Homo sapiens_hsa043100.81558855
65Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80308410
66Phenylalanine metabolism_Homo sapiens_hsa003600.78599124
67Pathways in cancer_Homo sapiens_hsa052000.78561340
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78362833
69Circadian rhythm_Homo sapiens_hsa047100.77219883
70Endometrial cancer_Homo sapiens_hsa052130.76912169
71Renal cell carcinoma_Homo sapiens_hsa052110.76074997
72Hepatitis B_Homo sapiens_hsa051610.74706627
73ABC transporters_Homo sapiens_hsa020100.74350540
74AMPK signaling pathway_Homo sapiens_hsa041520.73775736
75Prostate cancer_Homo sapiens_hsa052150.73122001
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72831239
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.72502804
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71452551
79Serotonergic synapse_Homo sapiens_hsa047260.69300674
80Choline metabolism in cancer_Homo sapiens_hsa052310.68719088
81Oxytocin signaling pathway_Homo sapiens_hsa049210.68664479
82Estrogen signaling pathway_Homo sapiens_hsa049150.68597414
83Thyroid cancer_Homo sapiens_hsa052160.68201587
84Glutamatergic synapse_Homo sapiens_hsa047240.67375521
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67128010
86Ras signaling pathway_Homo sapiens_hsa040140.66863847
87Arginine biosynthesis_Homo sapiens_hsa002200.66837093
88Hedgehog signaling pathway_Homo sapiens_hsa043400.65585930
89Melanogenesis_Homo sapiens_hsa049160.64994640
90Malaria_Homo sapiens_hsa051440.64791943
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63434714
92Pertussis_Homo sapiens_hsa051330.63363687
93HTLV-I infection_Homo sapiens_hsa051660.63142210
94Shigellosis_Homo sapiens_hsa051310.62614524
95Gastric acid secretion_Homo sapiens_hsa049710.61824223
96Notch signaling pathway_Homo sapiens_hsa043300.61234332
97Dilated cardiomyopathy_Homo sapiens_hsa054140.61044596
98Glioma_Homo sapiens_hsa052140.60329701
99Platelet activation_Homo sapiens_hsa046110.59642962
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.59204436
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58526697
102Viral myocarditis_Homo sapiens_hsa054160.58410154
103Endocytosis_Homo sapiens_hsa041440.58022586
104Non-small cell lung cancer_Homo sapiens_hsa052230.57176308
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56935600
106Rap1 signaling pathway_Homo sapiens_hsa040150.56891597
107MAPK signaling pathway_Homo sapiens_hsa040100.56122369
108Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55446361
109Pancreatic secretion_Homo sapiens_hsa049720.55251420
110Mineral absorption_Homo sapiens_hsa049780.54719963
111Oocyte meiosis_Homo sapiens_hsa041140.54393371
112Salivary secretion_Homo sapiens_hsa049700.54105129
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53589416
114HIF-1 signaling pathway_Homo sapiens_hsa040660.53074513
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.51229974
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50912433
117Insulin signaling pathway_Homo sapiens_hsa049100.50494720
118Legionellosis_Homo sapiens_hsa051340.49988835
119Leishmaniasis_Homo sapiens_hsa051400.49241958
120Tuberculosis_Homo sapiens_hsa051520.49165420
121Melanoma_Homo sapiens_hsa052180.49072562
122Salmonella infection_Homo sapiens_hsa051320.48992934
123Fatty acid biosynthesis_Homo sapiens_hsa000610.47237788
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46703323
125Glutathione metabolism_Homo sapiens_hsa004800.45329070
126Influenza A_Homo sapiens_hsa051640.43379581
127PPAR signaling pathway_Homo sapiens_hsa033200.43303107
128Fatty acid elongation_Homo sapiens_hsa000620.43153018
129Long-term potentiation_Homo sapiens_hsa047200.42761623
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41755047
131beta-Alanine metabolism_Homo sapiens_hsa004100.41223506
132Inositol phosphate metabolism_Homo sapiens_hsa005620.40997054
133Retinol metabolism_Homo sapiens_hsa008300.37397117
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.30914081
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.30343769
136Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29622476
137Calcium signaling pathway_Homo sapiens_hsa040200.28369909
138Nitrogen metabolism_Homo sapiens_hsa009100.26690582
139Circadian entrainment_Homo sapiens_hsa047130.23998853
140cAMP signaling pathway_Homo sapiens_hsa040240.21020783
141Glucagon signaling pathway_Homo sapiens_hsa049220.20582234
142Glycerolipid metabolism_Homo sapiens_hsa005610.19890043
143Amphetamine addiction_Homo sapiens_hsa050310.18872165
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.18375881

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