PGLYRP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Summary: This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)9.51956581
2keratinization (GO:0031424)9.37191899
3sphingoid metabolic process (GO:0046519)9.22674089
4regulation of water loss via skin (GO:0033561)9.06131688
5keratinocyte differentiation (GO:0030216)7.38619597
6sphingosine metabolic process (GO:0006670)7.28740429
7fatty acid elongation (GO:0030497)6.91872247
8diol metabolic process (GO:0034311)6.82075309
9multicellular organismal water homeostasis (GO:0050891)6.41701597
10keratinocyte proliferation (GO:0043616)6.04228752
11regulation of ruffle assembly (GO:1900027)5.88193562
12epidermal cell differentiation (GO:0009913)5.85302868
13bundle of His cell to Purkinje myocyte communication (GO:0086069)5.74130625
14surfactant homeostasis (GO:0043129)5.58649176
15regulation of phospholipase A2 activity (GO:0032429)5.50525201
16intermediate filament organization (GO:0045109)5.44768684
17gap junction assembly (GO:0016264)5.40489727
18water homeostasis (GO:0030104)5.37704567
19peptide cross-linking (GO:0018149)5.31181354
20* detection of bacterium (GO:0016045)5.30160307
21molting cycle (GO:0042303)5.26617530
22hair cycle (GO:0042633)5.26617530
23epidermis development (GO:0008544)5.07443870
24regulation of hypersensitivity (GO:0002883)4.88977486
25* detection of other organism (GO:0098543)4.79461292
26hemidesmosome assembly (GO:0031581)4.67529662
27keratinocyte development (GO:0003334)4.50581654
28phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.35862929
29skin morphogenesis (GO:0043589)4.34254032
30phosphatidylcholine acyl-chain remodeling (GO:0036151)4.17560087
31long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.15856403
32negative regulation of acute inflammatory response (GO:0002674)4.15642185
33establishment of tissue polarity (GO:0007164)4.14332150
34establishment of planar polarity (GO:0001736)4.14332150
35negative regulation of interleukin-17 production (GO:0032700)3.95665993
36sequestering of metal ion (GO:0051238)3.89006650
37cyclooxygenase pathway (GO:0019371)3.88032835
38response to phenylpropanoid (GO:0080184)3.84641128
39regulation of T cell chemotaxis (GO:0010819)3.82129674
40positive regulation of T cell chemotaxis (GO:0010820)3.82129674
41positive regulation of epidermal cell differentiation (GO:0045606)3.77697679
42phospholipid scrambling (GO:0017121)3.75022244
43regulation of chemokine secretion (GO:0090196)3.69936513
44negative regulation of T cell mediated immunity (GO:0002710)3.60217766
45* regulation of natural killer cell differentiation (GO:0032823)3.60112119
46phosphatidylserine metabolic process (GO:0006658)3.59839285
47intestinal epithelial cell development (GO:0060576)3.55508352
48ceramide biosynthetic process (GO:0046513)3.54809425
49G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.53996322
50long-chain fatty acid biosynthetic process (GO:0042759)3.53809692
51ectoderm development (GO:0007398)3.52384800
52epithelial cell differentiation involved in prostate gland development (GO:0060742)3.47859737
53positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.47535807
54interferon-gamma secretion (GO:0072643)3.47525624
55long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.47328749
56intermediate filament cytoskeleton organization (GO:0045104)3.46474113
57regulation of cell proliferation involved in kidney development (GO:1901722)3.46314587
58negative regulation of stress fiber assembly (GO:0051497)3.46241984
59fatty-acyl-CoA metabolic process (GO:0035337)3.43755151
60intermediate filament-based process (GO:0045103)3.43106478
61positive regulation of interleukin-4 production (GO:0032753)3.38057853
62positive regulation of hair cycle (GO:0042635)3.37277975
63positive regulation of hair follicle development (GO:0051798)3.37277975
64positive regulation of keratinocyte differentiation (GO:0045618)3.37239762
65regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.24695160
66regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.24279461
67positive regulation of interleukin-8 secretion (GO:2000484)3.18713753
68regulation of interleukin-8 secretion (GO:2000482)3.16328075
69negative regulation of interleukin-2 production (GO:0032703)3.15986961
70fatty-acyl-CoA biosynthetic process (GO:0046949)3.12429108
71very long-chain fatty acid metabolic process (GO:0000038)3.12000610
72regulation of keratinocyte differentiation (GO:0045616)3.09599966
73regulation of monocyte chemotaxis (GO:0090025)3.08854092
74hair follicle morphogenesis (GO:0031069)3.07817825
75negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.07481442
76positive regulation of Cdc42 GTPase activity (GO:0043089)3.07173197
77regulation of keratinocyte proliferation (GO:0010837)3.07061037
78positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.05398606
79primary alcohol catabolic process (GO:0034310)3.04978993
80sphingolipid biosynthetic process (GO:0030148)3.03415427
81positive regulation of vesicle fusion (GO:0031340)3.03263552
82negative regulation of kidney development (GO:0090185)3.02003179
83positive regulation of chemokine secretion (GO:0090197)3.00052676
84germ cell migration (GO:0008354)2.99983147
85defense response to fungus (GO:0050832)2.99939940
86atrioventricular valve morphogenesis (GO:0003181)2.99728811
87lateral sprouting from an epithelium (GO:0060601)2.99454925
88regulation of epidermis development (GO:0045682)2.99114079
89polarized epithelial cell differentiation (GO:0030859)2.96690714
90viral transcription (GO:0019083)2.92354668
91positive regulation of cellular amide metabolic process (GO:0034250)2.90946255
92phospholipid efflux (GO:0033700)2.89628049
93alditol phosphate metabolic process (GO:0052646)2.89395626
94phosphatidylinositol acyl-chain remodeling (GO:0036149)2.88233728
95retinal metabolic process (GO:0042574)2.88004761
96negative regulation of interleukin-8 production (GO:0032717)2.87785055
97phospholipid catabolic process (GO:0009395)2.87236879
98eyelid development in camera-type eye (GO:0061029)2.85846953
99positive regulation of cholesterol efflux (GO:0010875)2.85638469
100gland morphogenesis (GO:0022612)2.84127092
101negative regulation of lipase activity (GO:0060192)2.82925784
102ventricular cardiac muscle cell action potential (GO:0086005)2.82078070
103defense response to Gram-negative bacterium (GO:0050829)2.80851530
104antimicrobial humoral response (GO:0019730)2.76766480
105positive regulation of granulocyte chemotaxis (GO:0071624)2.75815400
106regulation of apoptotic process involved in morphogenesis (GO:1902337)2.73395778
107regulation of glomerular filtration (GO:0003093)2.72903141
108regulation of neuron projection regeneration (GO:0070570)2.72354161
109regulation of axon regeneration (GO:0048679)2.72354161
110translational termination (GO:0006415)2.71033951
111* detection of external biotic stimulus (GO:0098581)2.70338827
112inflammatory response to antigenic stimulus (GO:0002437)2.69757827
113regulation of hair cycle (GO:0042634)2.68400034
114glutathione biosynthetic process (GO:0006750)2.64295818
115* negative regulation of interferon-gamma production (GO:0032689)2.63425519
116response to UV-B (GO:0010224)2.63342007
117epithelial cell differentiation (GO:0030855)2.63053661
118regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.62606371
119chemical homeostasis within a tissue (GO:0048875)2.61424024
120regulation of interleukin-17 production (GO:0032660)2.60568407
121leukotriene metabolic process (GO:0006691)2.60130787
122negative regulation of cell fate specification (GO:0009996)2.59290142
123regulation of transforming growth factor beta1 production (GO:0032908)2.58359817
124regulation of protein localization to cell surface (GO:2000008)2.57226413
125epithelium development (GO:0060429)2.54687338
126negative regulation of keratinocyte proliferation (GO:0010839)2.54408066
127regulation of lymphocyte chemotaxis (GO:1901623)2.54317683
128positive regulation of antigen processing and presentation (GO:0002579)2.54042655
129cellular response to arsenic-containing substance (GO:0071243)2.53406300
130positive regulation of epidermis development (GO:0045684)2.51858532
131ceramide catabolic process (GO:0046514)2.50271964
132positive regulation of sterol transport (GO:0032373)2.50103838
133positive regulation of cholesterol transport (GO:0032376)2.50103838
134planar cell polarity pathway involved in neural tube closure (GO:0090179)2.49294189
135positive regulation of monocyte chemotaxis (GO:0090026)2.48661408
136positive regulation of mitochondrial membrane permeability (GO:0035794)2.48516962
137negative regulation of actin filament bundle assembly (GO:0032232)2.47784122
138regulation of heart rate by cardiac conduction (GO:0086091)2.45612114
139lymph vessel development (GO:0001945)2.45372662
140phosphatidylserine acyl-chain remodeling (GO:0036150)2.45319268
141nonribosomal peptide biosynthetic process (GO:0019184)2.45022472
142lipoxygenase pathway (GO:0019372)2.44215303
143regulation of epidermal cell differentiation (GO:0045604)2.44195982
144regulation of somitogenesis (GO:0014807)2.43607244
145regulation of Cdc42 GTPase activity (GO:0043088)2.42020990
146phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.41844397
147linoleic acid metabolic process (GO:0043651)2.41811406
148regulation of hair follicle development (GO:0051797)2.40061089
149peptidyl-tyrosine autophosphorylation (GO:0038083)2.38467650
150ephrin receptor signaling pathway (GO:0048013)2.38122802
151regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.37786771
152cell-substrate junction assembly (GO:0007044)2.34552381
153positive regulation of glomerulus development (GO:0090193)2.34292363
154negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.33694594
155chronic inflammatory response (GO:0002544)2.31793547
156desmosome organization (GO:0002934)14.1696986

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.88156004
2SOX9_24532713_ChIP-Seq_HFSC_Mouse2.61077198
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.58165170
4P63_26484246_Chip-Seq_KERATINOCYTES_Human2.58001091
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.42579489
6TP63_17297297_ChIP-ChIP_HaCaT_Human13.0438922
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.94991794
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.85687847
9SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.83034683
10SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.83034683
11ESR1_21235772_ChIP-Seq_MCF-7_Human1.81568502
12ESR2_21235772_ChIP-Seq_MCF-7_Human1.76128130
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72793547
14ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69018803
15FOXO3_23340844_ChIP-Seq_DLD1_Human1.65882472
16SOX2_20726797_ChIP-Seq_SW620_Human1.61217675
17VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.51004266
18GATA1_22025678_ChIP-Seq_K562_Human1.48730464
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48607604
20TCF4_18268006_ChIP-ChIP_LS174T_Human1.48499986
21TP63_23658742_ChIP-Seq_EP156T_Human1.43172130
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43083881
23TP53_18474530_ChIP-ChIP_U2OS_Human1.38433025
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31049537
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.30106611
26BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.28525492
27CJUN_26792858_Chip-Seq_BT549_Human1.27325314
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.25853621
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23950999
30AR_21572438_ChIP-Seq_LNCaP_Human1.22809486
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20234886
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19317094
33RXR_22108803_ChIP-Seq_LS180_Human1.16204546
34UBF1/2_26484160_Chip-Seq_HMECs_Human1.15105070
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13441826
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13441184
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13093542
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12911609
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12764320
40RUNX1_27514584_Chip-Seq_MCF-7_Human1.11755761
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11673112
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10617491
43AHR_22903824_ChIP-Seq_MCF-7_Human1.09920607
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07789023
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07789023
46E2F1_20622854_ChIP-Seq_HELA_Human1.07119349
47KLF5_25053715_ChIP-Seq_YYC3_Human1.06981832
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.05780417
49ERG_20517297_ChIP-Seq_VCAP_Human1.05729594
50GATA4_25053715_ChIP-Seq_YYC3_Human1.05458156
51TP63_22573176_ChIP-Seq_HFKS_Human1.03453039
52UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02860463
53* SMC4_20622854_ChIP-Seq_HELA_Human1.01575533
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01470297
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01221143
56BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99929069
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98740229
58* BCOR_27268052_Chip-Seq_Bcells_Human0.98587269
59GATA6_25053715_ChIP-Seq_YYC3_Human0.97836148
60IRF8_22096565_ChIP-ChIP_GC-B_Human0.97618398
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97367292
62EZH2_27294783_Chip-Seq_ESCs_Mouse0.97288862
63CDX2_20551321_ChIP-Seq_CACO-2_Human0.96223033
64HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96003025
65RNF2_27304074_Chip-Seq_ESCs_Mouse0.95324069
66FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.94906589
67TP53_20018659_ChIP-ChIP_R1E_Mouse0.94209936
68SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93567778
69* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93441775
70ZNF263_19887448_ChIP-Seq_K562_Human0.92878735
71SA1_27219007_Chip-Seq_ERYTHROID_Human0.92741405
72ARNT_22903824_ChIP-Seq_MCF-7_Human0.92014489
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91729740
74* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91436130
75STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90659558
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87980963
77P53_21459846_ChIP-Seq_SAOS-2_Human0.87930033
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87847679
79GATA3_24758297_ChIP-Seq_MCF-7_Human0.87733059
80FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87158397
81ELK3_25401928_ChIP-Seq_HUVEC_Human0.86701730
82VDR_22108803_ChIP-Seq_LS180_Human0.85959708
83GATA1_19941826_ChIP-Seq_K562_Human0.85827336
84DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85793849
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.84601105
86* TCF4_22108803_ChIP-Seq_LS180_Human0.83553868
87* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83350401
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82038012
89MTF2_20144788_ChIP-Seq_MESCs_Mouse0.81431347
90CBX2_27304074_Chip-Seq_ESCs_Mouse0.81377305
91RBPJ_21746931_ChIP-Seq_IB4_Human0.80162770
92FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79888190
93SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.78517346
94RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78105450
95GATA6_21074721_ChIP-Seq_CACO-2_Human0.78047928
96STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.77881836
97* BCAT_22108803_ChIP-Seq_LS180_Human0.77520727
98P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.77489244
99ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.76935590
100EGR1_19032775_ChIP-ChIP_M12_Human0.76405580
101ATF3_27146783_Chip-Seq_COLON_Human0.75853291
102* GATA2_19941826_ChIP-Seq_K562_Human0.74896419
103Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.74591186
104CEBPB_22108803_ChIP-Seq_LS180_Human0.74514187
105* CTCF_20526341_ChIP-Seq_ESCs_Human0.74358759
106KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.74244534
107RACK7_27058665_Chip-Seq_MCF-7_Human0.74000064
108PCGF2_27294783_Chip-Seq_NPCs_Mouse0.72899124
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.72676099
110GATA2_21666600_ChIP-Seq_HMVEC_Human0.72618690
111HTT_18923047_ChIP-ChIP_STHdh_Human0.72231072
112AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71908666
113* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.71668739
114JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71369615
115SOX2_27498859_Chip-Seq_STOMACH_Mouse0.70875542
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70384467
117NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70384467
118STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.70372212
119* BCL6_27268052_Chip-Seq_Bcells_Human0.70250438
120RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.70163814
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.70079181
122CLOCK_20551151_ChIP-Seq_293T_Human0.69697912
123ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69569844
124PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.68926230
125PPARA_22158963_ChIP-Seq_LIVER_Mouse0.67680349
126VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.67058799
127IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.66643914
128JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66497501
129TCF7_22412390_ChIP-Seq_EML_Mouse0.66257352
130RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.66172006
131SRY_22984422_ChIP-ChIP_TESTIS_Rat0.66075350
132FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.65529803
133SPI1_20517297_ChIP-Seq_HL60_Human0.65528910
134LXR_22292898_ChIP-Seq_THP-1_Human0.65465578
135TP53_16413492_ChIP-PET_HCT116_Human0.65037501
136* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.64399973
137P68_20966046_ChIP-Seq_HELA_Human0.63986355
138RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.63866565
139MYB_21317192_ChIP-Seq_ERMYB_Mouse0.63540457
140EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.63516001
141CTCF_27219007_Chip-Seq_Bcells_Human0.63483935
142PIAS1_25552417_ChIP-Seq_VCAP_Human0.63217317
143YY1_22570637_ChIP-Seq_MALME-3M_Human0.63078641
144* HNFA_21074721_ChIP-Seq_CACO-2_Human0.62799341
145FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.62780576

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.15619483
2MP0010234_abnormal_vibrissa_follicle6.12842314
3MP0005275_abnormal_skin_tensile5.32320846
4MP0004381_abnormal_hair_follicle4.98607427
5MP0005501_abnormal_skin_physiology4.73813802
6MP0003941_abnormal_skin_development4.00532106
7MP0005451_abnormal_body_composition3.62248328
8MP0000579_abnormal_nail_morphology3.54626957
9MP0002254_reproductive_system_inflammat3.51776616
10MP0002060_abnormal_skin_morphology3.47599380
11MP0001216_abnormal_epidermal_layer3.39349363
12MP0002098_abnormal_vibrissa_morphology3.18432996
13MP0010771_integument_phenotype3.02111630
14MP0010678_abnormal_skin_adnexa2.94340525
15MP0003878_abnormal_ear_physiology2.83663140
16MP0005377_hearing/vestibular/ear_phenot2.83663140
17MP0001346_abnormal_lacrimal_gland2.83437914
18MP0003453_abnormal_keratinocyte_physiol2.72560806
19MP0000383_abnormal_hair_follicle2.51576289
20MP0000647_abnormal_sebaceous_gland2.49121522
21MP0004885_abnormal_endolymph2.48740934
22MP0000377_abnormal_hair_follicle2.40126179
23MP0004947_skin_inflammation2.39292795
24MP0000467_abnormal_esophagus_morphology2.25296224
25MP0000427_abnormal_hair_cycle2.24106080
26MP0002009_preneoplasia2.18527879
27MP0001191_abnormal_skin_condition1.73339550
28MP0003566_abnormal_cell_adhesion1.72969803
29MP0000762_abnormal_tongue_morphology1.66258412
30MP0009931_abnormal_skin_appearance1.52473789
31MP0003011_delayed_dark_adaptation1.43634873
32MP0001851_eye_inflammation1.34149223
33MP0000367_abnormal_coat/_hair1.31285889
34MP0004185_abnormal_adipocyte_glucose1.31245696
35MP0003436_decreased_susceptibility_to1.27102973
36MP0002138_abnormal_hepatobiliary_system1.25883308
37MP0003136_yellow_coat_color1.16899403
38MP0001243_abnormal_dermal_layer1.15641553
39MP0001188_hyperpigmentation1.15057395
40MP0002095_abnormal_skin_pigmentation1.10346653
41MP0003705_abnormal_hypodermis_morpholog1.08071161
42MP0000516_abnormal_urinary_system1.03770113
43MP0005367_renal/urinary_system_phenotyp1.03770113
44MP0000566_synostosis0.97566848
45MP0001340_abnormal_eyelid_morphology0.96387779
46MP0002148_abnormal_hypersensitivity_rea0.94318759
47MP0002877_abnormal_melanocyte_morpholog0.93629128
48MP0003300_gastrointestinal_ulcer0.88956638
49MP0009379_abnormal_foot_pigmentation0.88193089
50MP0003191_abnormal_cellular_cholesterol0.79473878
51MP0002249_abnormal_larynx_morphology0.78881143
52MP0004043_abnormal_pH_regulation0.78675921
53MP0010386_abnormal_urinary_bladder0.77415688
54MP0002006_tumorigenesis0.76739990
55MP0003315_abnormal_perineum_morphology0.75988940
56MP0004782_abnormal_surfactant_physiolog0.75114801
57MP0000627_abnormal_mammary_gland0.74952918
58MP0002166_altered_tumor_susceptibility0.73403126
59MP0000465_gastrointestinal_hemorrhage0.71801210
60MP0005023_abnormal_wound_healing0.70943296
61MP0005075_abnormal_melanosome_morpholog0.70368489
62MP0005623_abnormal_meninges_morphology0.67441040
63MP0009053_abnormal_anal_canal0.67139478
64MP0002234_abnormal_pharynx_morphology0.65356549
65MP0010352_gastrointestinal_tract_polyps0.64433732
66MP0002277_abnormal_respiratory_mucosa0.64360979
67MP0003283_abnormal_digestive_organ0.64349692
68MP0009333_abnormal_splenocyte_physiolog0.59842210
69MP0001790_abnormal_immune_system0.58787316
70MP0005387_immune_system_phenotype0.58787316
71MP0000538_abnormal_urinary_bladder0.57830011
72MP0002090_abnormal_vision0.55412580
73MP0000613_abnormal_salivary_gland0.54979402
74MP0002282_abnormal_trachea_morphology0.54867358
75MP0005248_abnormal_Harderian_gland0.52742153
76MP0004264_abnormal_extraembryonic_tissu0.51862234
77MP0005647_abnormal_sex_gland0.49844939
78MP0003638_abnormal_response/metabolism_0.48759212
79MP0000685_abnormal_immune_system0.48569315
80MP0000470_abnormal_stomach_morphology0.48431738
81MP0001533_abnormal_skeleton_physiology0.47496998
82MP0001784_abnormal_fluid_regulation0.47299441
83MP0005508_abnormal_skeleton_morphology0.47049098
84MP0008004_abnormal_stomach_pH0.46991451
85MP0005390_skeleton_phenotype0.45975891
86MP0005025_abnormal_response_to0.45413547
87MP0002177_abnormal_outer_ear0.44359775
88MP0003950_abnormal_plasma_membrane0.42076162
89MP0001853_heart_inflammation0.42001402
90MP0003763_abnormal_thymus_physiology0.41613742
91MP0005076_abnormal_cell_differentiation0.41602464
92MP0003329_amyloid_beta_deposits0.40828791
93MP0004510_myositis0.40649310
94MP0004272_abnormal_basement_membrane0.40008008
95MP0000537_abnormal_urethra_morphology0.39858413
96MP0002233_abnormal_nose_morphology0.39810623
97MP0008260_abnormal_autophagy0.39544929
98MP0001485_abnormal_pinna_reflex0.38596458
99MP0003045_fibrosis0.38391588
100MP0001984_abnormal_olfaction0.38271294
101MP0010155_abnormal_intestine_physiology0.33681970
102MP0000858_altered_metastatic_potential0.32793886
103MP0005671_abnormal_response_to0.32537199
104MP0003195_calcinosis0.31591309
105MP0003755_abnormal_palate_morphology0.30588076
106MP0004019_abnormal_vitamin_homeostasis0.30315812
107MP0009764_decreased_sensitivity_to0.29915646
108MP0009672_abnormal_birth_weight0.29114747
109MP0001800_abnormal_humoral_immune0.28718300
110MP0009384_cardiac_valve_regurgitation0.28093283
111MP0001881_abnormal_mammary_gland0.27810104
112MP0002111_abnormal_tail_morphology0.27326437
113MP0001873_stomach_inflammation0.27146302
114MP0001545_abnormal_hematopoietic_system0.26773278
115MP0005397_hematopoietic_system_phenotyp0.26773278
116MP0006054_spinal_hemorrhage0.26664319
117MP0009785_altered_susceptibility_to0.26306525
118MP0004858_abnormal_nervous_system0.25722325
119MP0005409_darkened_coat_color0.25466773
120MP0005000_abnormal_immune_tolerance0.25244003
121MP0003385_abnormal_body_wall0.25197534
122MP0000372_irregular_coat_pigmentation0.24824009
123MP0009250_abnormal_appendicular_skeleto0.24361881
124MP0009765_abnormal_xenobiotic_induced0.23298303
125MP0002133_abnormal_respiratory_system0.21093604
126MP0005388_respiratory_system_phenotype0.21093604
127MP0004197_abnormal_fetal_growth/weight/0.20571841
128MP0000678_abnormal_parathyroid_gland0.20560783
129MP0001177_atelectasis0.20416669
130MP0001849_ear_inflammation0.20197775
131MP0002452_abnormal_antigen_presenting0.16859651
132MP0005375_adipose_tissue_phenotype0.15895479
133MP0005666_abnormal_adipose_tissue0.14768488
134MP0001765_abnormal_ion_homeostasis0.14570458
135MP0008789_abnormal_olfactory_epithelium0.14557745

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)7.65680602
2Oral leukoplakia (HP:0002745)6.97071968
3Increased IgE level (HP:0003212)6.89932915
4Abnormality of nail color (HP:0100643)6.81877601
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.62262372
6Palmoplantar hyperkeratosis (HP:0000972)6.59327123
7Plantar hyperkeratosis (HP:0007556)6.47527338
8Hypotrichosis (HP:0001006)6.46145842
9Congenital ichthyosiform erythroderma (HP:0007431)6.18839946
10Palmar hyperkeratosis (HP:0010765)6.16968878
11Right ventricular cardiomyopathy (HP:0011663)6.10812916
12Erythema (HP:0010783)5.98325458
13Woolly hair (HP:0002224)5.51151987
14Erythroderma (HP:0001019)5.31648922
15Lip pit (HP:0100267)5.04462973
16Onycholysis (HP:0001806)4.98047891
17Natal tooth (HP:0000695)4.34163650
18Sparse scalp hair (HP:0002209)4.23866252
19Fragile nails (HP:0001808)4.21963501
20Abnormality of secondary sexual hair (HP:0009888)4.00486355
21Abnormality of the axillary hair (HP:0100134)4.00486355
22Abnormal blistering of the skin (HP:0008066)3.80039662
23Hypohidrosis (HP:0000966)3.79141875
24Absent eyelashes (HP:0000561)3.52896460
25Acanthosis nigricans (HP:0000956)3.49646155
26Ventricular tachycardia (HP:0004756)3.49537934
27Thick nail (HP:0001805)3.42447565
28Follicular hyperkeratosis (HP:0007502)3.42192821
29Curly hair (HP:0002212)3.38514049
30Amniotic constriction ring (HP:0009775)3.36585145
31Abnormality of placental membranes (HP:0011409)3.36585145
32Conjunctival hamartoma (HP:0100780)3.34648948
33Advanced eruption of teeth (HP:0006288)3.33036193
34Dry hair (HP:0011359)3.24674192
35Corneal erosion (HP:0200020)3.19300767
36Sparse eyelashes (HP:0000653)3.19182503
37Palmoplantar keratoderma (HP:0000982)3.09011143
38Pruritus (HP:0000989)3.05372339
39Popliteal pterygium (HP:0009756)3.05222668
40Severe Myopia (HP:0011003)2.99761468
41Nail dystrophy (HP:0008404)2.96004285
42Furrowed tongue (HP:0000221)2.95998173
43Urticaria (HP:0001025)2.83954172
44Oligodontia (HP:0000677)2.78487051
45Abnormality of the gastric mucosa (HP:0004295)2.73524775
46Milia (HP:0001056)2.72626255
47Distal lower limb muscle weakness (HP:0009053)2.70002183
48Anhidrosis (HP:0000970)2.66678785
49Ectropion (HP:0000656)2.64538612
50Gangrene (HP:0100758)2.57209951
51Concave nail (HP:0001598)2.53788519
52Hyporeflexia of lower limbs (HP:0002600)2.51280846
53Corneal dystrophy (HP:0001131)2.49126840
54Ridged nail (HP:0001807)2.47944301
55Lack of skin elasticity (HP:0100679)2.47187900
56Brittle hair (HP:0002299)2.45290688
57Hypergammaglobulinemia (HP:0010702)2.44474744
58Dry skin (HP:0000958)2.44434407
59Ventricular fibrillation (HP:0001663)2.38201625
60Pustule (HP:0200039)2.37800013
61Autoamputation (HP:0001218)2.36564140
62Pili torti (HP:0003777)2.34693321
63Epidermoid cyst (HP:0200040)2.34581595
64Villous atrophy (HP:0011473)2.25495275
65Abnormality of small intestinal villus morphology (HP:0011472)2.25495275
66Paralysis (HP:0003470)2.21626639
67Multifactorial inheritance (HP:0001426)2.11805056
68Hypoplastic labia majora (HP:0000059)2.08537143
69Abnormality of the salivary glands (HP:0010286)2.08532097
70Stomatitis (HP:0010280)2.08354552
71Recurrent corneal erosions (HP:0000495)2.08210156
72Alopecia of scalp (HP:0002293)2.06929164
73Conical tooth (HP:0000698)2.04044522
74Selective tooth agenesis (HP:0001592)2.00197471
75Abnormality of hair growth rate (HP:0011363)1.99645766
76Slow-growing hair (HP:0002217)1.99645766
77Abnormality of the labia majora (HP:0012881)1.91688128
78Carious teeth (HP:0000670)1.91443235
79Hypoplasia of the iris (HP:0007676)1.87873297
80Blepharitis (HP:0000498)1.87161152
81Abnormal hemoglobin (HP:0011902)1.86518056
82Dehydration (HP:0001944)1.86336403
83Intention tremor (HP:0002080)1.85266879
84Sepsis (HP:0100806)1.83383264
85Prostate neoplasm (HP:0100787)1.82581285
86Absent eyebrow (HP:0002223)1.81723506
87Areflexia of lower limbs (HP:0002522)1.80259615
88Down-sloping shoulders (HP:0200021)1.79658311
89Eczematoid dermatitis (HP:0000976)1.79300132
90Hypodontia (HP:0000668)1.77897131
91Abnormality of the distal phalanges of the toes (HP:0010182)1.74586467
92Neonatal death (HP:0003811)1.72847111
93Keratoconjunctivitis sicca (HP:0001097)1.72811329
94Squamous cell carcinoma (HP:0002860)1.72726793
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.67861285
96Xerostomia (HP:0000217)1.67777527
97Abnormality of the fingernails (HP:0001231)1.67613431
98Laryngomalacia (HP:0001601)1.66348381
99Premature loss of primary teeth (HP:0006323)1.66320705
100Pterygium (HP:0001059)1.66220898
101Fasciculations (HP:0002380)1.65248547
102Malignant hyperthermia (HP:0002047)1.61442196
103Hyperhidrosis (HP:0000975)1.61420418
104Anonychia (HP:0001798)1.61340597
105Recurrent bacterial skin infections (HP:0005406)1.61095289
106Fine hair (HP:0002213)1.59847132
107Autoimmune hemolytic anemia (HP:0001890)1.57728676
108Achilles tendon contracture (HP:0001771)1.57090707
109Aplasia involving bones of the extremities (HP:0009825)1.57089397
110Aplasia involving bones of the upper limbs (HP:0009823)1.57089397
111Aplasia of the phalanges of the hand (HP:0009802)1.57089397
112Aplasia cutis congenita (HP:0001057)1.55840044
113Papilloma (HP:0012740)1.55278367
114Verrucae (HP:0200043)1.55278367
115Skin ulcer (HP:0200042)1.55218108
116Keratoconjunctivitis (HP:0001096)1.55021818
117Abnormality of the dental root (HP:0006486)1.54803133
118Taurodontia (HP:0000679)1.54803133
119Abnormality of permanent molar morphology (HP:0011071)1.54803133
120Absent hair (HP:0002298)1.53917009
121Abnormality of cells of the erythroid lineage (HP:0012130)1.53610684
122Bifid scrotum (HP:0000048)1.53359924
123Abnormal hair laboratory examination (HP:0003328)1.51768117
124Melanocytic nevus (HP:0000995)1.51447614
125Hoarse voice (HP:0001609)1.51186128
126Hypoplasia of dental enamel (HP:0006297)1.50233311
127Hamartoma of the eye (HP:0010568)1.47628569
128Sex reversal (HP:0012245)1.47415391
129Abnormal sex determination (HP:0012244)1.47415391
130Fatigable weakness (HP:0003473)1.45633654
131Atrophic scars (HP:0001075)1.45592675
132Abnormality of molar (HP:0011077)1.44984061
133Abnormality of molar morphology (HP:0011070)1.44984061
134Duplicated collecting system (HP:0000081)1.39905320
135Abnormality of the dental pulp (HP:0006479)1.37840864
136Hypoplastic toenails (HP:0001800)1.36669290

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.26470505
2MST44.82588251
3TGFBR14.38873941
4LATS13.72380259
5MAPKAPK33.62431062
6MAP3K33.60416820
7FER3.21719074
8CDK123.03522689
9TRPM72.82937792
10GRK12.66713344
11LMTK22.48016585
12MAP3K62.43006292
13ERBB32.40789315
14BCR2.30085292
15FGFR32.14091594
16ERN12.12769446
17MAP3K21.93703030
18EPHB21.93691194
19BLK1.90058291
20RIPK41.88198509
21MET1.82375389
22STK241.67411709
23TNK21.63268893
24PIK3CG1.61308512
25MAP3K91.59285985
26PIM21.55372562
27SGK4941.51579760
28SGK2231.51579760
29PRPF4B1.49525175
30RPS6KB21.49437117
31FGFR11.48500132
32MAPKAPK51.48144269
33LRRK21.44118149
34EPHA21.36821388
35MAP3K131.36598587
36IRAK31.36421133
37MAP3K141.29290962
38STK101.28155089
39IRAK11.25417014
40SIK11.24909748
41JAK31.23601027
42DYRK1B1.18040250
43EPHA41.16877763
44NUAK11.15893603
45GRK61.12253382
46MAPK71.04368677
47LATS21.04344934
48PDGFRA1.03028347
49SMG11.02434389
50EPHA30.99473084
51PTK60.99165203
52PKN10.99131859
53CASK0.94290768
54EPHB10.88332406
55NME10.87271091
56JAK10.83607304
57CDK30.82779980
58ITK0.81376860
59STK38L0.81328369
60IRAK40.79028367
61TGFBR20.78156545
62CDC42BPA0.77795553
63FRK0.77431932
64HCK0.76215347
65DYRK30.73833900
66PAK30.73180089
67MAP4K10.69239859
68PRKCE0.68898983
69EEF2K0.68760076
70KIT0.66914474
71NEK90.66128232
72FGR0.65514690
73MAP3K70.63187084
74TESK10.62916433
75MAPKAPK20.62157735
76CHUK0.61882676
77SIK30.61537606
78EIF2AK20.59933572
79TAOK10.56620734
80PTK20.56121858
81PRKD20.55518420
82BTK0.55193643
83CDK60.54784818
84TRIB30.53658753
85LIMK10.50417108
86BMX0.50338799
87STK380.49100410
88TXK0.48610482
89MTOR0.48372553
90HIPK20.48356961
91MAP3K10.48293889
92MOS0.47524249
93SGK10.47330350
94MAP2K60.46500695
95MAPK120.46091104
96RPS6KB10.45633289
97DMPK0.45558433
98IRAK20.44745487
99MUSK0.42783659
100MARK20.42063727
101TYK20.41778622
102STK390.40086135
103RPS6KA10.39982535
104BMPR20.39134161
105YES10.37983908
106PRKD10.37920529
107PDGFRB0.37589193
108CSNK1D0.37449691
109PRKAA20.36785404
110ABL10.36586793
111MAP3K100.36534393
112FLT30.36141357
113ICK0.36113901
114ERBB40.35651885
115GRK70.35234036
116ROCK20.34576364
117ROCK10.33892486
118IKBKB0.33034022
119TYRO30.32656421
120STK30.32538071
121TEC0.32393259
122NLK0.32149901
123AURKA0.31737780
124MATK0.31205086
125ADRBK10.29893525
126PRKCQ0.29236983
127FYN0.28622294
128MAPK150.28573505
129IGF1R0.27471111
130SRC0.27460149
131FGFR40.27335413
132FGFR20.26359842
133MAP2K30.25581960
134CSK0.25150443
135SYK0.24729856
136RIPK10.24015429
137JAK20.23805157
138GSK3A0.23137787
139PRKCA0.22728909
140MAPK40.22718750
141NTRK20.22608287
142TBK10.22237126
143WNK10.21695882
144ARAF0.21274837
145IKBKE0.21042198
146PRKG10.20131751

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.68939878
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.36070241
3Sphingolipid metabolism_Homo sapiens_hsa006004.03727391
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.01214723
5Fatty acid elongation_Homo sapiens_hsa000623.67326322
6Histidine metabolism_Homo sapiens_hsa003402.51327136
7Linoleic acid metabolism_Homo sapiens_hsa005912.31979435
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.26422573
9Phenylalanine metabolism_Homo sapiens_hsa003602.10663864
10Retinol metabolism_Homo sapiens_hsa008301.92125625
11Arachidonic acid metabolism_Homo sapiens_hsa005901.81642417
12Staphylococcus aureus infection_Homo sapiens_hsa051501.80044008
13Steroid biosynthesis_Homo sapiens_hsa001001.75080437
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.73943183
15Ribosome_Homo sapiens_hsa030101.69489548
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65684249
17Ether lipid metabolism_Homo sapiens_hsa005651.61060183
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49767175
19Sphingolipid signaling pathway_Homo sapiens_hsa040711.49093068
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48724221
21Fatty acid biosynthesis_Homo sapiens_hsa000611.38329457
22Choline metabolism in cancer_Homo sapiens_hsa052311.29104307
23Chemical carcinogenesis_Homo sapiens_hsa052041.25522127
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24217872
25Axon guidance_Homo sapiens_hsa043601.20920142
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.17174499
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.15808934
28Tight junction_Homo sapiens_hsa045301.11905213
29Graft-versus-host disease_Homo sapiens_hsa053321.11821270
30Phototransduction_Homo sapiens_hsa047441.08304088
31Glutathione metabolism_Homo sapiens_hsa004801.03521925
32Acute myeloid leukemia_Homo sapiens_hsa052211.03401303
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00811075
34Circadian rhythm_Homo sapiens_hsa047101.00408305
35Collecting duct acid secretion_Homo sapiens_hsa049660.98774597
36Allograft rejection_Homo sapiens_hsa053300.98520850
37Toxoplasmosis_Homo sapiens_hsa051450.98045209
38Tyrosine metabolism_Homo sapiens_hsa003500.97578328
39Influenza A_Homo sapiens_hsa051640.93844550
40Adherens junction_Homo sapiens_hsa045200.92313541
41Basal cell carcinoma_Homo sapiens_hsa052170.92124336
42p53 signaling pathway_Homo sapiens_hsa041150.91912044
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91659234
44Bladder cancer_Homo sapiens_hsa052190.89731193
45Autoimmune thyroid disease_Homo sapiens_hsa053200.88132059
46Asthma_Homo sapiens_hsa053100.87507248
47beta-Alanine metabolism_Homo sapiens_hsa004100.87384751
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86560811
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85755016
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83724621
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83189473
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81739114
53Pertussis_Homo sapiens_hsa051330.78559208
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77926839
55ABC transporters_Homo sapiens_hsa020100.76434801
56VEGF signaling pathway_Homo sapiens_hsa043700.75230963
57Hepatitis C_Homo sapiens_hsa051600.70899735
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70816548
59Renin-angiotensin system_Homo sapiens_hsa046140.68859685
60Melanogenesis_Homo sapiens_hsa049160.68717934
61Fat digestion and absorption_Homo sapiens_hsa049750.68001131
62Mineral absorption_Homo sapiens_hsa049780.67330926
63Pancreatic secretion_Homo sapiens_hsa049720.67089590
64GnRH signaling pathway_Homo sapiens_hsa049120.66023118
65Ras signaling pathway_Homo sapiens_hsa040140.65984470
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.64749804
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.64189648
68Hippo signaling pathway_Homo sapiens_hsa043900.63953961
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.63587018
70Hematopoietic cell lineage_Homo sapiens_hsa046400.63197837
71Serotonergic synapse_Homo sapiens_hsa047260.63040528
72Renin secretion_Homo sapiens_hsa049240.62288079
73Glioma_Homo sapiens_hsa052140.58648614
74Proteoglycans in cancer_Homo sapiens_hsa052050.58440143
75Amoebiasis_Homo sapiens_hsa051460.58093858
76Rap1 signaling pathway_Homo sapiens_hsa040150.56496433
77Galactose metabolism_Homo sapiens_hsa000520.55921334
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55376710
79MicroRNAs in cancer_Homo sapiens_hsa052060.53738120
80Rheumatoid arthritis_Homo sapiens_hsa053230.53650418
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52828872
82Osteoclast differentiation_Homo sapiens_hsa043800.52248376
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.51778009
84Salmonella infection_Homo sapiens_hsa051320.51453911
85Dorso-ventral axis formation_Homo sapiens_hsa043200.51310109
86HIF-1 signaling pathway_Homo sapiens_hsa040660.49968031
87Pancreatic cancer_Homo sapiens_hsa052120.49445158
88Small cell lung cancer_Homo sapiens_hsa052220.48553717
89ECM-receptor interaction_Homo sapiens_hsa045120.48481483
90Notch signaling pathway_Homo sapiens_hsa043300.48097292
91Type I diabetes mellitus_Homo sapiens_hsa049400.47329975
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46892326
93Antigen processing and presentation_Homo sapiens_hsa046120.46474150
94Thyroid cancer_Homo sapiens_hsa052160.45860104
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45254311
96T cell receptor signaling pathway_Homo sapiens_hsa046600.45105595
97Fatty acid metabolism_Homo sapiens_hsa012120.45094634
98Salivary secretion_Homo sapiens_hsa049700.44964079
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.43131929
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.42201030
101Malaria_Homo sapiens_hsa051440.42160610
102Ovarian steroidogenesis_Homo sapiens_hsa049130.39538904
103Melanoma_Homo sapiens_hsa052180.39463976
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.39055506
105Herpes simplex infection_Homo sapiens_hsa051680.38811997
106Platelet activation_Homo sapiens_hsa046110.37496437
107Gastric acid secretion_Homo sapiens_hsa049710.37387300
108Measles_Homo sapiens_hsa051620.36864662
109Phagosome_Homo sapiens_hsa041450.36372824
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36198476
111Long-term depression_Homo sapiens_hsa047300.36184382
112ErbB signaling pathway_Homo sapiens_hsa040120.35695121
113Hedgehog signaling pathway_Homo sapiens_hsa043400.35086554
114Viral myocarditis_Homo sapiens_hsa054160.34866676
115B cell receptor signaling pathway_Homo sapiens_hsa046620.34416705
116Renal cell carcinoma_Homo sapiens_hsa052110.34346846
117Tuberculosis_Homo sapiens_hsa051520.33972918
118Lysosome_Homo sapiens_hsa041420.33929319
119Insulin signaling pathway_Homo sapiens_hsa049100.33827406
120TNF signaling pathway_Homo sapiens_hsa046680.33725076
121MAPK signaling pathway_Homo sapiens_hsa040100.33678809
122Leishmaniasis_Homo sapiens_hsa051400.33628668
123Complement and coagulation cascades_Homo sapiens_hsa046100.33231611
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.33045731
125Vibrio cholerae infection_Homo sapiens_hsa051100.31832942
126African trypanosomiasis_Homo sapiens_hsa051430.31585243
127Calcium signaling pathway_Homo sapiens_hsa040200.31571745
128TGF-beta signaling pathway_Homo sapiens_hsa043500.31558404
129Fructose and mannose metabolism_Homo sapiens_hsa000510.31198498
130Endocytosis_Homo sapiens_hsa041440.30412647
131Vitamin digestion and absorption_Homo sapiens_hsa049770.30138789
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29018081
133Long-term potentiation_Homo sapiens_hsa047200.28680355
134Oxytocin signaling pathway_Homo sapiens_hsa049210.28632190
135PPAR signaling pathway_Homo sapiens_hsa033200.28119817
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27227496
137Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27140085
138Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26788197
139Chronic myeloid leukemia_Homo sapiens_hsa052200.26752725
140Shigellosis_Homo sapiens_hsa051310.25874933

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