PGM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.67462222
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.67462222
3L-phenylalanine metabolic process (GO:0006558)5.54753645
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.54753645
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.16595991
6nuclear pore complex assembly (GO:0051292)5.10506767
7alpha-linolenic acid metabolic process (GO:0036109)4.99505791
8lysine catabolic process (GO:0006554)4.98268446
9lysine metabolic process (GO:0006553)4.98268446
10glyoxylate metabolic process (GO:0046487)4.93078234
11aromatic amino acid family catabolic process (GO:0009074)4.90735685
12kynurenine metabolic process (GO:0070189)4.71882575
132-oxoglutarate metabolic process (GO:0006103)4.63341933
14fatty acid transmembrane transport (GO:1902001)4.59640364
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.57109476
16carnitine shuttle (GO:0006853)4.54745674
17nuclear pore organization (GO:0006999)4.50110443
18sulfur amino acid catabolic process (GO:0000098)4.38848704
19bile acid biosynthetic process (GO:0006699)4.35586684
20tryptophan catabolic process (GO:0006569)4.31636032
21indole-containing compound catabolic process (GO:0042436)4.31636032
22indolalkylamine catabolic process (GO:0046218)4.31636032
23cellular ketone body metabolic process (GO:0046950)4.31599450
24regulation of triglyceride catabolic process (GO:0010896)4.31285462
25urea cycle (GO:0000050)4.23539662
26urea metabolic process (GO:0019627)4.23539662
27fatty acid beta-oxidation (GO:0006635)4.21500704
28amino-acid betaine metabolic process (GO:0006577)4.17411547
29negative regulation of fibrinolysis (GO:0051918)4.16254310
30high-density lipoprotein particle remodeling (GO:0034375)4.15952469
31valine metabolic process (GO:0006573)4.14552358
32cysteine metabolic process (GO:0006534)4.11006718
33acetyl-CoA metabolic process (GO:0006084)4.08810810
34tryptophan metabolic process (GO:0006568)4.06582622
35aspartate family amino acid catabolic process (GO:0009068)4.04510879
36complement activation, alternative pathway (GO:0006957)4.01583806
37regulation of protein activation cascade (GO:2000257)3.94836378
38muscle filament sliding (GO:0030049)3.94612079
39actin-myosin filament sliding (GO:0033275)3.94612079
40ketone body metabolic process (GO:1902224)3.94601851
41fatty acid oxidation (GO:0019395)3.94351453
42positive regulation of fatty acid beta-oxidation (GO:0032000)3.94296540
43short-chain fatty acid metabolic process (GO:0046459)3.92911538
44formation of translation preinitiation complex (GO:0001731)3.92285375
45serine family amino acid catabolic process (GO:0009071)3.90732557
46tyrosine metabolic process (GO:0006570)3.89352425
47nitrogen cycle metabolic process (GO:0071941)3.89274430
48protein carboxylation (GO:0018214)3.88825077
49peptidyl-glutamic acid carboxylation (GO:0017187)3.88825077
50alpha-amino acid catabolic process (GO:1901606)3.88811290
51lipid oxidation (GO:0034440)3.88354904
52regulation of fibrinolysis (GO:0051917)3.87666776
53fatty acid catabolic process (GO:0009062)3.85657677
54tricarboxylic acid cycle (GO:0006099)3.85460095
55plasma lipoprotein particle clearance (GO:0034381)3.83361107
56reverse cholesterol transport (GO:0043691)3.79288913
57DNA unwinding involved in DNA replication (GO:0006268)3.78828254
58ribosome assembly (GO:0042255)3.78300391
59acylglycerol homeostasis (GO:0055090)3.77901284
60triglyceride homeostasis (GO:0070328)3.77901284
61dicarboxylic acid biosynthetic process (GO:0043650)3.77336452
62homocysteine metabolic process (GO:0050667)3.73096507
63plasma lipoprotein particle remodeling (GO:0034369)3.72674546
64protein-lipid complex remodeling (GO:0034368)3.72674546
65macromolecular complex remodeling (GO:0034367)3.72674546
66monocarboxylic acid catabolic process (GO:0072329)3.72364163
67oxaloacetate metabolic process (GO:0006107)3.72313786
68regulation of complement activation (GO:0030449)3.70458333
69pore complex assembly (GO:0046931)3.69058729
70bile acid metabolic process (GO:0008206)3.68888791
71branched-chain amino acid catabolic process (GO:0009083)3.68882897
72cellular amino acid catabolic process (GO:0009063)3.67864209
73positive regulation of fatty acid oxidation (GO:0046321)3.67150484
74aromatic amino acid family metabolic process (GO:0009072)3.66383790
75regulation of sequestering of triglyceride (GO:0010889)3.63482544
76regulation of cholesterol esterification (GO:0010872)3.61932608
77mitotic chromosome condensation (GO:0007076)3.60484897
78carnitine metabolic process (GO:0009437)3.59628742
79DNA strand elongation involved in DNA replication (GO:0006271)3.58702818
80positive regulation of lipid catabolic process (GO:0050996)3.57577550
81protein localization to chromosome, centromeric region (GO:0071459)3.56269518
82phospholipid homeostasis (GO:0055091)3.55067052
83cellular modified amino acid catabolic process (GO:0042219)3.54324814
84coenzyme catabolic process (GO:0009109)3.52241340
85regulation of skeletal muscle contraction (GO:0014819)3.52043241
86branched-chain amino acid metabolic process (GO:0009081)3.51905334
87DNA strand elongation (GO:0022616)3.51789090
88neutrophil activation involved in immune response (GO:0002283)3.50664120
89ethanol oxidation (GO:0006069)3.49636076
90organic acid catabolic process (GO:0016054)3.48989720
91carboxylic acid catabolic process (GO:0046395)3.48989720
92tricarboxylic acid metabolic process (GO:0072350)3.48973021
93glutamate metabolic process (GO:0006536)3.48152554
94succinate metabolic process (GO:0006105)3.47841556
95carnitine transmembrane transport (GO:1902603)3.46391630
96regulation of fatty acid oxidation (GO:0046320)3.46237758
97cellular glucuronidation (GO:0052695)3.45637040
98regulation of fatty acid beta-oxidation (GO:0031998)3.44280600
99phospholipid efflux (GO:0033700)3.43335916
100telomere maintenance via semi-conservative replication (GO:0032201)3.43219559
101protein localization to kinetochore (GO:0034501)3.38209351
102biotin metabolic process (GO:0006768)3.34122228
103carnitine transport (GO:0015879)3.34097639
104amino-acid betaine transport (GO:0015838)3.34097639
105negative regulation of cholesterol transport (GO:0032375)3.33266282
106negative regulation of sterol transport (GO:0032372)3.33266282
107fatty acid homeostasis (GO:0055089)3.30743255
108mitotic metaphase plate congression (GO:0007080)3.25482827
109actin-mediated cell contraction (GO:0070252)3.22348583
110glycine metabolic process (GO:0006544)3.20072225
1114-hydroxyproline metabolic process (GO:0019471)3.19908257
112regulation of cholesterol homeostasis (GO:2000188)3.19125888
113mitotic sister chromatid segregation (GO:0000070)3.18747347
114arginine metabolic process (GO:0006525)3.17720840
115telomere maintenance via recombination (GO:0000722)3.16217439
116NADH metabolic process (GO:0006734)3.15019567
117mitotic recombination (GO:0006312)3.06439683
118mitotic nuclear envelope disassembly (GO:0007077)3.04212677
119sister chromatid segregation (GO:0000819)3.03480732
120establishment of integrated proviral latency (GO:0075713)3.02134557
121ribosomal large subunit biogenesis (GO:0042273)2.97937408
122pinocytosis (GO:0006907)2.97074079
123DNA replication initiation (GO:0006270)2.95206425
124purine nucleobase biosynthetic process (GO:0009113)2.92065430
125CENP-A containing nucleosome assembly (GO:0034080)2.88716255
126regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88662169
127mitotic sister chromatid cohesion (GO:0007064)2.86509151
128IMP biosynthetic process (GO:0006188)2.86352160
129membrane disassembly (GO:0030397)2.85071027
130nuclear envelope disassembly (GO:0051081)2.85071027
131establishment of chromosome localization (GO:0051303)2.78725319
132metaphase plate congression (GO:0051310)2.77824737
133DNA topological change (GO:0006265)2.74285056
134cellular protein complex localization (GO:0034629)2.73644222
135nucleobase biosynthetic process (GO:0046112)2.71719543
136folic acid-containing compound biosynthetic process (GO:0009396)2.71190849
137response to peptidoglycan (GO:0032494)2.67607110
138ribosomal small subunit assembly (GO:0000028)2.66170191
139chromatin remodeling at centromere (GO:0031055)2.64314090
140regulation of chromosome segregation (GO:0051983)2.63492615
141negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.61807219
142DNA replication checkpoint (GO:0000076)2.60917590
143mitotic spindle checkpoint (GO:0071174)2.60863659
144double-strand break repair via nonhomologous end joining (GO:0006303)2.60696002
145non-recombinational repair (GO:0000726)2.60696002
146negative regulation of chromosome segregation (GO:0051985)2.59077709
147spindle checkpoint (GO:0031577)2.58577729
148mitotic spindle assembly checkpoint (GO:0007094)2.57735640
149IMP metabolic process (GO:0046040)2.57662654
150positive regulation of chromosome segregation (GO:0051984)2.57049815
151negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.56811376
152negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.56811376
153negative regulation of mitotic sister chromatid segregation (GO:0033048)2.56811376
154negative regulation of mitotic sister chromatid separation (GO:2000816)2.56811376
155negative regulation of sister chromatid segregation (GO:0033046)2.56811376
156anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.56055343
157regulation of mitotic metaphase/anaphase transition (GO:0030071)2.55932584
158regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.55932584
159spindle assembly checkpoint (GO:0071173)2.55790215
160regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.54912660
161negative regulation of DNA repair (GO:0045738)2.53526726
162nucleobase-containing small molecule interconversion (GO:0015949)2.53402778
163regulation of centriole replication (GO:0046599)2.51746901
164protein complex localization (GO:0031503)2.50824137
165negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.45881797
166negative regulation of ligase activity (GO:0051352)2.45881797
167DNA duplex unwinding (GO:0032508)2.45863232
168regulation of mitotic sister chromatid separation (GO:0010965)2.45233773
169regulation of mitotic sister chromatid segregation (GO:0033047)2.45233773
170regulation of sister chromatid segregation (GO:0033045)2.45233773
171proteasome assembly (GO:0043248)2.44648576
172positive regulation of gamma-delta T cell activation (GO:0046645)2.44636115
173positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.44555106
174ribonucleoprotein complex biogenesis (GO:0022613)2.42894987
175regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.40748176
176DNA replication-independent nucleosome assembly (GO:0006336)2.40009647
177DNA replication-independent nucleosome organization (GO:0034724)2.40009647
178regulation of sister chromatid cohesion (GO:0007063)2.39346361
179viral mRNA export from host cell nucleus (GO:0046784)2.37702017
180ribosome biogenesis (GO:0042254)2.37385819
181DNA geometric change (GO:0032392)2.37191526
182deoxyribonucleotide biosynthetic process (GO:0009263)2.36773875
183detection of other organism (GO:0098543)2.35045019
184establishment of viral latency (GO:0019043)2.33726924
185rRNA methylation (GO:0031167)2.32930088
186DNA ligation (GO:0006266)2.32605788
187tRNA aminoacylation for protein translation (GO:0006418)2.30441006
188G1/S transition of mitotic cell cycle (GO:0000082)2.28778761
189cell cycle G1/S phase transition (GO:0044843)2.28778761
190regulation of translational termination (GO:0006449)2.28375792
191modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.27331739
192positive regulation by organism of defense response of other organism involved in symbiotic interact2.27331739
193modulation by symbiont of host immune response (GO:0052553)2.27331739
194positive regulation by symbiont of host defense response (GO:0052509)2.27331739
195modulation by symbiont of host defense response (GO:0052031)2.27331739
196modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.27331739
197telomere maintenance via telomere lengthening (GO:0010833)2.26413432
198maturation of SSU-rRNA (GO:0030490)2.26159237
199rRNA modification (GO:0000154)2.25715187
200protein export from nucleus (GO:0006611)2.25540741

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.75280890
2* PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.58195682
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.95622639
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.18185059
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.45566539
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.67266160
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.43474858
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.73242091
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.70152287
10* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.67939381
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.34598941
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.28509077
13MYC_18555785_ChIP-Seq_MESCs_Mouse3.28300966
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15970338
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.79741115
16AR_21909140_ChIP-Seq_LNCAP_Human2.73411789
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66369189
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65135296
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.61667923
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.58558492
21CLOCK_20551151_ChIP-Seq_293T_Human2.55337457
22* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.52209875
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24186497
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18074858
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.16939873
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.16353453
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14901635
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10699982
29* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.06323176
30TP63_17297297_ChIP-ChIP_HaCaT_Human2.05309550
31RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04973708
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00369246
33ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0995338
34TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.94625750
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91798338
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88943882
37* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87389988
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86109938
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84890143
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.84043777
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.82403536
42ELK1_19687146_ChIP-ChIP_HELA_Human1.81299755
43HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.81173502
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73822297
45SPI1_23547873_ChIP-Seq_NB4_Human1.73303123
46DCP1A_22483619_ChIP-Seq_HELA_Human1.72631219
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.72479595
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71917362
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.71282161
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68006565
51ZNF263_19887448_ChIP-Seq_K562_Human1.67237080
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66930923
53* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66664487
54* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63975062
55SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.63661913
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62726095
57FOXP3_21729870_ChIP-Seq_TREG_Human1.59195510
58* VDR_23849224_ChIP-Seq_CD4+_Human1.58812105
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57701168
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.56457054
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55431039
62TFEB_21752829_ChIP-Seq_HELA_Human1.54318467
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53121889
64* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52559062
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.50091254
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47481118
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46765860
68FOXA2_19822575_ChIP-Seq_HepG2_Human1.46347013
69TBX20_22080862_ChIP-Seq_HEART_Mouse1.45694143
70TBX20_22328084_ChIP-Seq_HEART_Mouse1.45694143
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43808722
72MYC_22102868_ChIP-Seq_BL_Human1.43458386
73IRF8_21731497_ChIP-ChIP_J774_Mouse1.42077001
74* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41855268
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40551055
76NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39826978
77XRN2_22483619_ChIP-Seq_HELA_Human1.37488002
78GATA1_22025678_ChIP-Seq_K562_Human1.36652739
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33137927
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33006411
81IRF8_22096565_ChIP-ChIP_GC-B_Human1.30598643
82TTF2_22483619_ChIP-Seq_HELA_Human1.29311628
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25726729
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25218176
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22902902
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22586168
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21899451
88BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20776196
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20554272
90MYB_26560356_Chip-Seq_TH2_Human1.18930321
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17967192
92HNF4A_19822575_ChIP-Seq_HepG2_Human1.17312330
93HTT_18923047_ChIP-ChIP_STHdh_Human1.17175719
94STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17086354
95GABP_19822575_ChIP-Seq_HepG2_Human1.16277246
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14221978
97STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13773403
98BP1_19119308_ChIP-ChIP_Hs578T_Human1.12787329
99MYB_26560356_Chip-Seq_TH1_Human1.12558227
100SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12225085
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11129905
102FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10487365
103ESR2_21235772_ChIP-Seq_MCF-7_Human1.10381164
104THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10050224
105NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08861199
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08497119
107* EP300_21415370_ChIP-Seq_HL-1_Mouse1.07568502
108* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06781419
109NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05788643
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05705414
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05086686
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04756677
113IRF8_27001747_Chip-Seq_BMDM_Mouse1.04634819
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03784113
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03336347
116KDM5A_27292631_Chip-Seq_BREAST_Human0.99362377
117LXR_22292898_ChIP-Seq_THP-1_Human0.99355927
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99354417
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98669248
120SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97739739
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97343132
122SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95404622
123SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95404622
124SCL_19346495_ChIP-Seq_HPC-7_Human0.95188870
125CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94529408
126AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94419952
127CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94299811
128TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93487524
129HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93314206
130GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93299933
131RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91477731
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89537287
133DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89300042
134MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88735212
135VDR_21846776_ChIP-Seq_THP-1_Human0.88691053
136MAF_26560356_Chip-Seq_TH1_Human0.88236054
137AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83919143
138PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82761001
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81601779
140* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.81176051
141SOX2_27498859_Chip-Seq_STOMACH_Mouse0.81127325
142CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.80369842
143STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80204447
144CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79556986
145* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78031361
146TRIM28_21343339_ChIP-Seq_HEK293_Human0.75701025
147BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75359656
148GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.74950113
149GATA4_21415370_ChIP-Seq_HL-1_Mouse0.73991344
150RACK7_27058665_Chip-Seq_MCF-7_Human0.71568254
151NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70928447
152NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70928447
153PPAR_26484153_Chip-Seq_NCI-H1993_Human0.69439140
154SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.68362050
155ESR1_21235772_ChIP-Seq_MCF-7_Human0.68351257
156EGR1_19032775_ChIP-ChIP_M12_Human0.67159288
157NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.66243365
158CTCF_27219007_Chip-Seq_Bcells_Human0.66136147
159DNAJC2_21179169_ChIP-ChIP_NT2_Human0.65707536
160GATA4_25053715_ChIP-Seq_YYC3_Human0.64988012
161MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.64868186
162ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.64346001
163RARA_24833708_ChIP-Seq_LIVER_Mouse0.62252327
164SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.62221495
165RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61818331
166CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.61606680
167SALL4_18804426_ChIP-ChIP_XEN_Mouse0.61005240
168OCT4_20526341_ChIP-Seq_ESCs_Human0.60685930
169GATA1_19941826_ChIP-Seq_K562_Human0.60493514
170NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.60354742
171* CEBPB_22108803_ChIP-Seq_LS180_Human0.59874966
172SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.59647052
173TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.59075413
174* BCL6_27268052_Chip-Seq_Bcells_Human0.58980534
175CBP_21632823_ChIP-Seq_H3396_Human0.57943045
176GATA2_19941826_ChIP-Seq_K562_Human0.57456081
177* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.57218903
178BCOR_27268052_Chip-Seq_Bcells_Human0.57048850
179IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.56895897
180TAF2_19829295_ChIP-Seq_ESCs_Human0.56356312
181GATA1_19941827_ChIP-Seq_MEL_Mouse0.55628615
182ATF3_27146783_Chip-Seq_COLON_Human0.55546626
183CSB_26484114_Chip-Seq_FIBROBLAST_Human0.54852493
184KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.54829634
185RAC3_21632823_ChIP-Seq_H3396_Human0.54081067
186CTCF_21964334_ChIP-Seq_BJAB-B_Human0.53741732
187P68_20966046_ChIP-Seq_HELA_Human0.53346545
188* AR_20517297_ChIP-Seq_VCAP_Human0.52755895
189GATA3_24758297_ChIP-Seq_MCF-7_Human0.52311675
190MYC_27129775_Chip-Seq_CORNEA_Mouse0.52215991
191PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.52119533
192CREB1_26743006_Chip-Seq_LNCaP_Human0.51833937

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.08976945
2MP0005360_urolithiasis5.37127311
3MP0005085_abnormal_gallbladder_physiolo4.60918686
4MP0005365_abnormal_bile_salt4.50769783
5MP0003806_abnormal_nucleotide_metabolis3.67337074
6MP0002837_dystrophic_cardiac_calcinosis3.63726285
7MP0008875_abnormal_xenobiotic_pharmacok3.50827139
8MP0003646_muscle_fatigue3.37049753
9MP0010094_abnormal_chromosome_stability3.08014543
10MP0010329_abnormal_lipoprotein_level3.02330093
11MP0008057_abnormal_DNA_replication2.95909489
12MP0004957_abnormal_blastocyst_morpholog2.92518852
13MP0000749_muscle_degeneration2.81580034
14MP0003252_abnormal_bile_duct2.75740256
15MP0000751_myopathy2.70172433
16MP0004130_abnormal_muscle_cell2.68531087
17MP0009840_abnormal_foam_cell2.64289976
18MP0002796_impaired_skin_barrier2.61533051
19MP0003111_abnormal_nucleus_morphology2.57046984
20MP0005083_abnormal_biliary_tract2.49691113
21MP0010352_gastrointestinal_tract_polyps2.48895429
22MP0004036_abnormal_muscle_relaxation2.48810937
23MP0003693_abnormal_embryo_hatching2.47938771
24MP0002396_abnormal_hematopoietic_system2.43837362
25MP0005332_abnormal_amino_acid2.34042920
26MP0004145_abnormal_muscle_electrophysio2.29344584
27MP0003077_abnormal_cell_cycle2.28565857
28MP0002877_abnormal_melanocyte_morpholog2.28331453
29MP0010234_abnormal_vibrissa_follicle2.15578618
30MP0004084_abnormal_cardiac_muscle2.15410016
31MP0003195_calcinosis2.12202633
32MP0005670_abnormal_white_adipose1.98223571
33MP0001835_abnormal_antigen_presentation1.94892619
34MP0002269_muscular_atrophy1.93749196
35MP0002118_abnormal_lipid_homeostasis1.91251843
36MP0008260_abnormal_autophagy1.88217563
37MP0003941_abnormal_skin_development1.88148573
38MP0006036_abnormal_mitochondrial_physio1.87552676
39MP0003191_abnormal_cellular_cholesterol1.85446840
40MP0004087_abnormal_muscle_fiber1.84737261
41MP0008058_abnormal_DNA_repair1.84383833
42MP0001666_abnormal_nutrient_absorption1.83818885
43MP0005330_cardiomyopathy1.82991622
44MP0005501_abnormal_skin_physiology1.79071966
45MP0000747_muscle_weakness1.78205816
46MP0000609_abnormal_liver_physiology1.74490311
47MP0008007_abnormal_cellular_replicative1.74241325
48MP0002166_altered_tumor_susceptibility1.72680274
49MP0005319_abnormal_enzyme/_coenzyme1.72151011
50MP0003705_abnormal_hypodermis_morpholog1.71667756
51MP0005620_abnormal_muscle_contractility1.68914113
52MP0002106_abnormal_muscle_physiology1.61764892
53MP0003566_abnormal_cell_adhesion1.59998532
54MP0005584_abnormal_enzyme/coenzyme_acti1.59208199
55MP0005666_abnormal_adipose_tissue1.57366712
56MP0010307_abnormal_tumor_latency1.54624438
57MP0008932_abnormal_embryonic_tissue1.54578849
58MP0005464_abnormal_platelet_physiology1.53867853
59MP0002006_tumorigenesis1.52298424
60MP0004215_abnormal_myocardial_fiber1.52243702
61MP0001853_heart_inflammation1.50615214
62MP0003828_pulmonary_edema1.50607982
63MP0003786_premature_aging1.46220949
64MP0003763_abnormal_thymus_physiology1.44296628
65MP0000759_abnormal_skeletal_muscle1.43507621
66MP0000350_abnormal_cell_proliferation1.40919100
67MP0002971_abnormal_brown_adipose1.38733060
68MP0001730_embryonic_growth_arrest1.38348801
69MP0001216_abnormal_epidermal_layer1.37938832
70MP0000750_abnormal_muscle_regeneration1.37165834
71MP0004947_skin_inflammation1.36201225
72MP0009333_abnormal_splenocyte_physiolog1.34166526
73MP0002972_abnormal_cardiac_muscle1.34133958
74MP0002009_preneoplasia1.33671708
75MP0004808_abnormal_hematopoietic_stem1.33419096
76MP0003453_abnormal_keratinocyte_physiol1.32963233
77MP0005369_muscle_phenotype1.29855253
78MP0002332_abnormal_exercise_endurance1.28310176
79MP0008775_abnormal_heart_ventricle1.27694792
80MP0002060_abnormal_skin_morphology1.27382147
81MP0005058_abnormal_lysosome_morphology1.26323738
82MP0003300_gastrointestinal_ulcer1.25902617
83MP0000858_altered_metastatic_potential1.25393256
84MP0001764_abnormal_homeostasis1.24717809
85MP0002419_abnormal_innate_immunity1.24699529
86MP0002398_abnormal_bone_marrow1.22713613
87MP0003724_increased_susceptibility_to1.21560337
88MP0000490_abnormal_crypts_of1.20452241
89MP0004019_abnormal_vitamin_homeostasis1.19714641
90MP0002019_abnormal_tumor_incidence1.18910934
91MP0005385_cardiovascular_system_phenoty1.17197327
92MP0001544_abnormal_cardiovascular_syste1.17197327
93MP0003436_decreased_susceptibility_to1.15516725
94MP0004264_abnormal_extraembryonic_tissu1.14672239
95MP0001800_abnormal_humoral_immune1.14308419
96MP0002452_abnormal_antigen_presenting1.14238688
97MP0006035_abnormal_mitochondrial_morpho1.13927787
98MP0005451_abnormal_body_composition1.13655637
99MP0002132_abnormal_respiratory_system1.12842631
100MP0004233_abnormal_muscle_weight1.11663007
101MP0005266_abnormal_metabolism1.10497893
102MP0000313_abnormal_cell_death1.10249268
103MP0003221_abnormal_cardiomyocyte_apopto1.09500285
104MP0010630_abnormal_cardiac_muscle1.09432263
105MP0002148_abnormal_hypersensitivity_rea1.08771264
106MP0001697_abnormal_embryo_size1.08390949
107MP0001672_abnormal_embryogenesis/_devel1.08254613
108MP0005380_embryogenesis_phenotype1.08254613
109MP0003656_abnormal_erythrocyte_physiolo1.07699436
110MP0009785_altered_susceptibility_to1.07430185
111MP0004185_abnormal_adipocyte_glucose1.07420835
112MP0002078_abnormal_glucose_homeostasis1.07358761
113MP0005000_abnormal_immune_tolerance1.06756435
114MP0002722_abnormal_immune_system1.06389837
115MP0005075_abnormal_melanosome_morpholog1.06049839
116MP0003186_abnormal_redox_activity1.05399694
117MP0003984_embryonic_growth_retardation1.04619558
118MP0002420_abnormal_adaptive_immunity1.04524485
119MP0001819_abnormal_immune_cell1.04296181
120MP0002080_prenatal_lethality1.03734414
121MP0000465_gastrointestinal_hemorrhage1.03379932
122MP0003868_abnormal_feces_composition1.02668974
123MP0000703_abnormal_thymus_morphology1.02523536
124MP0005025_abnormal_response_to1.02418671
125MP0003448_altered_tumor_morphology1.02391786
126MP0009697_abnormal_copulation1.01895698
127MP0009643_abnormal_urine_homeostasis1.01338194
128MP0002088_abnormal_embryonic_growth/wei1.01282922
129MP0002086_abnormal_extraembryonic_tissu1.00967233
130MP0002723_abnormal_immune_serum1.00692063
131MP0005334_abnormal_fat_pad1.00615108
132MP0006138_congestive_heart_failure0.98150347
133MP0002138_abnormal_hepatobiliary_system0.98017742
134MP0005397_hematopoietic_system_phenotyp0.97603902
135MP0001545_abnormal_hematopoietic_system0.97603902
136MP0003303_peritoneal_inflammation0.97272805
137MP0000689_abnormal_spleen_morphology0.96655147
138MP0002429_abnormal_blood_cell0.96530028
139MP0005375_adipose_tissue_phenotype0.96380770
140MP0000685_abnormal_immune_system0.95020914
141MP0005535_abnormal_body_temperature0.94888376
142MP0000358_abnormal_cell_content/0.94620753
143MP0003011_delayed_dark_adaptation0.91961135
144MP0005671_abnormal_response_to0.91006222
145MP0000716_abnormal_immune_system0.90546021
146MP0010155_abnormal_intestine_physiology0.90444102
147MP0000015_abnormal_ear_pigmentation0.90101584
148MP0000598_abnormal_liver_morphology0.89684027
149MP0005621_abnormal_cell_physiology0.89356012
150MP0002405_respiratory_system_inflammati0.89016915
151MP0001191_abnormal_skin_condition0.88968844
152MP0010368_abnormal_lymphatic_system0.86079776
153MP0000377_abnormal_hair_follicle0.85652290
154MP0001851_eye_inflammation0.82485573
155MP0009931_abnormal_skin_appearance0.81186935
156MP0005023_abnormal_wound_healing0.81024221
157MP0005376_homeostasis/metabolism_phenot0.80658134
158MP0000604_amyloidosis0.79902677
159MP0003137_abnormal_impulse_conducting0.79433689
160MP0004484_altered_response_of0.71884916
161MP0003329_amyloid_beta_deposits0.71819994
162MP0009642_abnormal_blood_homeostasis0.70282708
163MP0000230_abnormal_systemic_arterial0.69532123
164MP0005636_abnormal_mineral_homeostasis0.68091677
165MP0002254_reproductive_system_inflammat0.68062566
166MP0002108_abnormal_muscle_morphology0.67456086
167MP0009115_abnormal_fat_cell0.66380142
168MP0002822_catalepsy0.65305894
169MP0005448_abnormal_energy_balance0.62680110
170MP0005647_abnormal_sex_gland0.61910082
171MP0004085_abnormal_heartbeat0.61204123
172MP0008438_abnormal_cutaneous_collagen0.61053101
173MP0009763_increased_sensitivity_to0.60567049
174MP0002127_abnormal_cardiovascular_syste0.60419360
175MP0000013_abnormal_adipose_tissue0.59384894
176MP0009384_cardiac_valve_regurgitation0.58587960
177MP0002970_abnormal_white_adipose0.55934747
178MP0004043_abnormal_pH_regulation0.55864417
179MP0001661_extended_life_span0.55187382
180MP0009764_decreased_sensitivity_to0.54209860
181MP0003959_abnormal_lean_body0.53009831
182MP0001756_abnormal_urination0.52498814
183MP0005408_hypopigmentation0.51144908
184MP0008469_abnormal_protein_level0.50474651
185MP0002909_abnormal_adrenal_gland0.49709211
186MP0003950_abnormal_plasma_membrane0.48324162
187MP0000003_abnormal_adipose_tissue0.46343152

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.37425057
2Exercise-induced muscle cramps (HP:0003710)5.35852213
3Myoglobinuria (HP:0002913)5.02593255
4Deep venous thrombosis (HP:0002625)4.69517510
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.55559121
6Intrahepatic cholestasis (HP:0001406)4.55306513
7Xanthomatosis (HP:0000991)4.46525028
8Hypobetalipoproteinemia (HP:0003563)4.32265308
9Rhabdomyolysis (HP:0003201)4.10871321
10Ketosis (HP:0001946)4.02295381
11Hyperammonemia (HP:0001987)3.99423380
12Abnormality of monocarboxylic acid metabolism (HP:0010996)3.96921628
13Hypolipoproteinemia (HP:0010981)3.88726336
14Hypoglycemic coma (HP:0001325)3.88507552
15Hypoalphalipoproteinemia (HP:0003233)3.85564066
16Hyperlipoproteinemia (HP:0010980)3.80301215
17Muscle hypertrophy of the lower extremities (HP:0008968)3.66258510
18Hyperglycinuria (HP:0003108)3.61798418
19Muscle fiber inclusion bodies (HP:0100299)3.60679849
20Abnormality of nail color (HP:0100643)3.59797833
21Ketoacidosis (HP:0001993)3.58790109
22Prolonged partial thromboplastin time (HP:0003645)3.58444153
23Calf muscle hypertrophy (HP:0008981)3.58345821
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.49364207
25Abnormality of fatty-acid metabolism (HP:0004359)3.48927736
26Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.48437331
27Abnormality of glycine metabolism (HP:0010895)3.42166593
28Abnormality of serine family amino acid metabolism (HP:0010894)3.42166593
29Complement deficiency (HP:0004431)3.33577415
30Hyperglycinemia (HP:0002154)3.30255592
31Chromosomal breakage induced by crosslinking agents (HP:0003221)3.26437204
32Type 1 muscle fiber predominance (HP:0003803)3.21243518
33Muscle stiffness (HP:0003552)3.15484593
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.14917851
35Hyporeflexia of lower limbs (HP:0002600)3.11352713
36Nemaline bodies (HP:0003798)3.11230940
37Chromsome breakage (HP:0040012)3.09709667
38Sudden death (HP:0001699)3.00812205
39Epidermoid cyst (HP:0200040)2.97343178
40Abnormality of glutamine family amino acid metabolism (HP:0010902)2.94600962
41Recurrent abscess formation (HP:0002722)2.92356048
42Abnormality of dicarboxylic acid metabolism (HP:0010995)2.90857431
43Dicarboxylic aciduria (HP:0003215)2.90857431
44Cholecystitis (HP:0001082)2.90236552
45Abnormal gallbladder physiology (HP:0012438)2.90236552
46Cholelithiasis (HP:0001081)2.89853649
47Recurrent bacterial skin infections (HP:0005406)2.88047582
48Abnormal gallbladder morphology (HP:0012437)2.77784852
49Muscle fiber splitting (HP:0003555)2.77190910
50Cerebral edema (HP:0002181)2.76650566
51Eczematoid dermatitis (HP:0000976)2.74590585
52Distal arthrogryposis (HP:0005684)2.72494765
53Difficulty running (HP:0009046)2.72386802
54Asymmetric septal hypertrophy (HP:0001670)2.72382800
55Oral leukoplakia (HP:0002745)2.71847118
56Increased connective tissue (HP:0009025)2.68319635
57EMG: myopathic abnormalities (HP:0003458)2.67704181
58Abnormality of the common coagulation pathway (HP:0010990)2.66758624
59Abnormality of aspartate family amino acid metabolism (HP:0010899)2.66572684
60Onycholysis (HP:0001806)2.65959839
61Metabolic acidosis (HP:0001942)2.63665094
62Abnormality of sulfur amino acid metabolism (HP:0004339)2.62442019
63Abnormality of methionine metabolism (HP:0010901)2.57245193
64Gout (HP:0001997)2.56751134
65Abnormality of the calf musculature (HP:0001430)2.53378996
66Recurrent viral infections (HP:0004429)2.53012956
67Congenital ichthyosiform erythroderma (HP:0007431)2.51507975
68Joint hemorrhage (HP:0005261)2.51187617
69Skin nodule (HP:0200036)2.49911367
70Increased IgE level (HP:0003212)2.48312628
71B lymphocytopenia (HP:0010976)2.45604578
72Lethargy (HP:0001254)2.43844562
73Palpitations (HP:0001962)2.42722915
74Fat malabsorption (HP:0002630)2.42405764
75Abnormality of serum amino acid levels (HP:0003112)2.41397586
76Hypercholesterolemia (HP:0003124)2.40672470
77Myelodysplasia (HP:0002863)2.39722049
78Abnormality of the intrinsic pathway (HP:0010989)2.38712670
79Ventricular tachycardia (HP:0004756)2.37116672
80Hyperbilirubinemia (HP:0002904)2.37029013
81Abnormality of the preputium (HP:0100587)2.34359433
82Abnormality of purine metabolism (HP:0004352)2.33413174
83Subaortic stenosis (HP:0001682)2.32877453
84Abnormality of the left ventricular outflow tract (HP:0011103)2.32877453
85Myotonia (HP:0002486)2.31830935
86Late onset (HP:0003584)2.28520916
87Palmar hyperkeratosis (HP:0010765)2.28411094
88Acute myeloid leukemia (HP:0004808)2.28073622
89Abnormality of complement system (HP:0005339)2.27956825
90Erythema (HP:0010783)2.27940631
91Palmoplantar hyperkeratosis (HP:0000972)2.27232234
92Myopathic facies (HP:0002058)2.27062402
93Selective tooth agenesis (HP:0001592)2.27034801
94Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.25683919
95Hepatic necrosis (HP:0002605)2.25324361
96Lipoatrophy (HP:0100578)2.23788921
97Abnormality of oral frenula (HP:0000190)2.23503199
98Autoimmune hemolytic anemia (HP:0001890)2.23011370
99Generalized aminoaciduria (HP:0002909)2.22902562
100Right ventricular cardiomyopathy (HP:0011663)2.22861787
101Round ear (HP:0100830)2.21937225
102Ankyloglossia (HP:0010296)2.21457478
103Sparse eyelashes (HP:0000653)2.19075759
104Ragged-red muscle fibers (HP:0003200)2.18579410
105Abnormality of nucleobase metabolism (HP:0010932)2.17776001
106Abnormality of chromosome stability (HP:0003220)2.17463183
107Panhypogammaglobulinemia (HP:0003139)2.17278500
108Urticaria (HP:0001025)2.16302491
109Multiple enchondromatosis (HP:0005701)2.14653938
110IgM deficiency (HP:0002850)2.13438894
111Ulnar deviation of the wrist (HP:0003049)2.12773603
112Increased muscle lipid content (HP:0009058)2.12390158
113Abnormality of macrophages (HP:0004311)2.11239725
114Hyperinsulinemic hypoglycemia (HP:0000825)2.09377449
115Osteolytic defects of the hand bones (HP:0009699)2.09206461
116Osteolytic defects of the phalanges of the hand (HP:0009771)2.09206461
117Thick nail (HP:0001805)2.08763552
118Delayed CNS myelination (HP:0002188)2.08472024
119Plantar hyperkeratosis (HP:0007556)2.08153703
120Abnormality of B cell number (HP:0010975)2.07461112
121Abnormality of glycolysis (HP:0004366)2.06628290
122Increased serum pyruvate (HP:0003542)2.06628290
123Increased purine levels (HP:0004368)2.06500615
124Hyperuricemia (HP:0002149)2.06500615
125Hepatosplenomegaly (HP:0001433)2.05583669
126Reticulocytopenia (HP:0001896)2.05407072
127Hyperglycemia (HP:0003074)2.05263756
128Hepatocellular carcinoma (HP:0001402)2.05146593
129Nephroblastoma (Wilms tumor) (HP:0002667)2.05131893
130Neonatal onset (HP:0003623)2.04579550
131Erythroderma (HP:0001019)2.04501407
132Absent phalangeal crease (HP:0006109)2.04373443
133Microvesicular hepatic steatosis (HP:0001414)2.04045310
134Viral hepatitis (HP:0006562)2.04031200
135Squamous cell carcinoma (HP:0002860)2.03094131
136Abnormality of the gallbladder (HP:0005264)2.01402586
137Acute encephalopathy (HP:0006846)2.01176035
138Hypoglycemic seizures (HP:0002173)1.99924579
139T lymphocytopenia (HP:0005403)1.99657349
140Vomiting (HP:0002013)1.98744270
141Dilated cardiomyopathy (HP:0001644)1.97472651
142Vacuolated lymphocytes (HP:0001922)1.93939218
143Abnormal foot bone ossification (HP:0010675)1.92225207
144Recurrent skin infections (HP:0001581)1.92094927
145Oligomenorrhea (HP:0000876)1.89550985
146Agnosia (HP:0010524)1.89372906
147Embryonal renal neoplasm (HP:0011794)1.88738207
148Cutaneous melanoma (HP:0012056)1.87764295
149Skin ulcer (HP:0200042)1.87758119
150Amaurosis fugax (HP:0100576)1.87075476
151Aplasia/Hypoplasia of the thymus (HP:0010515)1.86561415
152Abnormality of pyrimidine metabolism (HP:0004353)1.86501656
153Premature ovarian failure (HP:0008209)1.86396846
154Deep philtrum (HP:0002002)1.86299610
155Syringomyelia (HP:0003396)1.86100951
156Spinal cord lesions (HP:0100561)1.86100951
157Progressive external ophthalmoplegia (HP:0000590)1.85840212
158Combined immunodeficiency (HP:0005387)1.85002981
159Rhabdomyosarcoma (HP:0002859)1.84648417
160Lymphoma (HP:0002665)1.84614669
161Thrombocytosis (HP:0001894)1.84379031
162Osteomyelitis (HP:0002754)1.82573016
163Ectropion (HP:0000656)1.82328746
164Duodenal stenosis (HP:0100867)1.82115949
165Small intestinal stenosis (HP:0012848)1.82115949
166Poikiloderma (HP:0001029)1.78808101
167Entropion (HP:0000621)1.78684316
168Periodontitis (HP:0000704)1.78060823
169Colitis (HP:0002583)1.77998856
170Chronic obstructive pulmonary disease (HP:0006510)1.76675057
171Obstructive lung disease (HP:0006536)1.76675057
172Blepharitis (HP:0000498)1.75366141
173Deviation of the thumb (HP:0009603)1.73635960
174Abnormality of T cells (HP:0002843)1.72837844
175Abnormality of the umbilical cord (HP:0010881)1.72395080
176Abnormality of the prostate (HP:0008775)1.71682024
177Abnormal lung lobation (HP:0002101)1.71303703
178Cellulitis (HP:0100658)1.70859388
179Abnormality of T cell physiology (HP:0011840)1.70779556
180Abnormal umbilical cord blood vessels (HP:0011403)1.69949098
181Single umbilical artery (HP:0001195)1.69949098
182Abnormality of the fetal cardiovascular system (HP:0010948)1.69949098
183Abnormality of T cell number (HP:0011839)1.69757090
184Pallor (HP:0000980)1.69394215
185Orthostatic hypotension (HP:0001278)1.68393762
186Abnormality of the salivary glands (HP:0010286)1.67250997
187Inflammation of the large intestine (HP:0002037)1.66584744
188Granulocytopenia (HP:0001913)1.66351653
189Gastrointestinal inflammation (HP:0004386)1.66022700
190Medulloblastoma (HP:0002885)1.65977419
191Abnormal platelet volume (HP:0011876)1.65951844
192Pili torti (HP:0003777)1.65695193
193Recurrent fungal infections (HP:0002841)1.64664616
194Rough bone trabeculation (HP:0100670)1.64596283
195Micronodular cirrhosis (HP:0001413)1.63494570
196Reduced antithrombin III activity (HP:0001976)1.63378427
197Short middle phalanx of the 5th finger (HP:0004220)1.63056195
198Mediastinal lymphadenopathy (HP:0100721)1.62619897

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.24441836
2OBSCN4.92889148
3TTN3.81234432
4TRIB33.77633268
5PKN23.74197042
6PHKG13.58878323
7PHKG23.58878323
8SCYL23.23775653
9BUB13.17646507
10PBK3.11000853
11EIF2AK33.10801756
12SIK13.06561208
13EIF2AK12.79417853
14TTK2.56158159
15CDC72.51074774
16PDK32.48555991
17PDK42.48555991
18SRPK12.38858488
19NEK12.36049329
20TSSK62.26393055
21ERN12.19631145
22BMPR22.16647521
23FLT32.06792331
24LMTK22.00849591
25NME21.97998981
26FGFR41.96659519
27MAP2K31.96539280
28PLK41.95225436
29PIK3CG1.88909702
30MAP3K121.88611640
31PINK11.77292638
32MAP2K41.68218870
33SMG11.64343742
34MST41.62436814
35RIPK41.62318931
36INSRR1.59810114
37MYLK1.58418720
38MAP3K71.58147495
39PIK3CA1.57651037
40MST1R1.54357880
41TESK21.48469117
42STK101.48021940
43BRSK21.47857978
44WEE11.43161269
45PAK41.39453416
46ZAK1.37939775
47RPS6KB21.33958116
48NEK91.27628860
49PDK21.24291125
50PRKAA21.23553834
51MAPK121.23303823
52NME11.22758702
53CDK61.21352411
54STK161.21138076
55RIPK11.20790726
56IRAK31.17501796
57MAP3K141.15845687
58TEC1.12794668
59MAPK111.12288449
60MAP3K81.11245221
61JAK31.10520462
62PTK61.09721159
63PLK31.08025295
64MAP3K61.05073436
65VRK21.04185340
66STK38L1.04176781
67STK241.03536960
68CLK11.02889106
69CDK41.02645630
70AURKB1.02468355
71CAMK1D1.01506060
72PRKAA10.99372969
73IRAK40.95555812
74CDK70.93805676
75BLK0.92121524
76MAP3K30.91447828
77MAP2K60.90847500
78TAF10.88956800
79PLK10.88818901
80TIE10.86414359
81FGR0.85347968
82CDK120.83403430
83MKNK10.83302077
84BTK0.82966169
85STK30.82500936
86CHEK20.82333085
87EIF2AK20.82115658
88PASK0.82074844
89STK40.80085625
90ATR0.79728797
91MAPKAPK30.77727409
92NUAK10.76382119
93ERBB40.73745945
94CSK0.73257271
95VRK10.71962305
96FES0.71828078
97NEK20.70787855
98RAF10.70642508
99SIK30.70002021
100ALK0.69745878
101YES10.68261544
102CCNB10.66431467
103DMPK0.65993015
104KDR0.65181989
105CHEK10.64923240
106MELK0.64532806
107MAP3K110.60933940
108BRD40.60458037
109ERBB30.60082782
110JAK20.59897746
111TAOK20.59871611
112RPS6KA40.59636311
113PDGFRA0.59142098
114RET0.58957367
115MAP3K50.58453270
116ILK0.58437441
117CAMK2G0.58436132
118PRPF4B0.57690866
119TYK20.57482017
120CAMK1G0.56918405
121LATS10.56442645
122MAP3K20.55723341
123PRKACG0.55707622
124TBK10.54775599
125KSR20.54519770
126PAK30.53827942
127TGFBR10.53488818
128ZAP700.52549841
129MAP2K10.52402143
130PDPK10.52113081
131MET0.51133464
132ITK0.51128457
133MUSK0.50463230
134ATM0.50385194
135TAOK30.49119820
136HCK0.48983299
137FGFR10.48912324
138JAK10.48253786
139MATK0.47309227
140AKT20.46757467
141AURKA0.45954882
142PDK10.44074933
143LATS20.43789157
144MAP3K130.41277210
145PRKD10.41014507
146EPHB10.40762682
147EPHA20.40296826
148ABL20.39496351
149CDK80.39338298
150PIM10.38943381
151FGFR30.38837130
152PRKG20.38194435
153FRK0.38187117
154LYN0.38075028
155ROCK10.37345611
156MAP3K100.37098422
157MAPK40.35777783
158SGK30.34422589
159LRRK20.33208466
160CAMK2D0.32972691
161BMX0.32966709
162EPHA30.30242487
163PRKACB0.30166491
164PRKD30.29722742
165MAP3K10.29452400
166FER0.29325513
167PTK2B0.28479538
168DAPK30.27250279
169PRKCZ0.26274641
170MTOR0.25908474
171EEF2K0.25068921
172PRKACA0.25034034
173TGFBR20.24716699
174PRKCH0.23651951
175STK380.23366971
176TRPM70.22514010
177LIMK10.22494108
178FGFR20.21725516
179GSK3A0.21636007
180ERBB20.20535227

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.98507515
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.61202012
3Mismatch repair_Homo sapiens_hsa034303.43535434
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.37963305
5Fatty acid degradation_Homo sapiens_hsa000713.05601087
6Nitrogen metabolism_Homo sapiens_hsa009103.04766512
7Propanoate metabolism_Homo sapiens_hsa006402.94333801
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.94273187
9Proteasome_Homo sapiens_hsa030502.93265106
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.86997562
11Arginine biosynthesis_Homo sapiens_hsa002202.80545371
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.79318069
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.78733787
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.68535217
15Non-homologous end-joining_Homo sapiens_hsa034502.56155370
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.54362805
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.49461134
18Fatty acid metabolism_Homo sapiens_hsa012122.41241284
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.40901531
20Tryptophan metabolism_Homo sapiens_hsa003802.38160803
21Nucleotide excision repair_Homo sapiens_hsa034202.32456318
22Cell cycle_Homo sapiens_hsa041102.18200232
23Butanoate metabolism_Homo sapiens_hsa006502.17975087
24Carbon metabolism_Homo sapiens_hsa012002.13718559
25PPAR signaling pathway_Homo sapiens_hsa033202.13206294
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.06254766
27Pyruvate metabolism_Homo sapiens_hsa006202.05460600
28RNA transport_Homo sapiens_hsa030132.03440683
29Homologous recombination_Homo sapiens_hsa034402.00243830
30Base excision repair_Homo sapiens_hsa034101.99792998
31Ribosome_Homo sapiens_hsa030101.98444605
32Complement and coagulation cascades_Homo sapiens_hsa046101.93391139
33Peroxisome_Homo sapiens_hsa041461.92214809
34Spliceosome_Homo sapiens_hsa030401.83276133
35Biosynthesis of amino acids_Homo sapiens_hsa012301.81171390
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.73417689
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63845221
38beta-Alanine metabolism_Homo sapiens_hsa004101.63724712
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63152893
40* Starch and sucrose metabolism_Homo sapiens_hsa005001.59484856
41Phenylalanine metabolism_Homo sapiens_hsa003601.52725476
42Leishmaniasis_Homo sapiens_hsa051401.47253334
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47077872
44* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.45118454
45Legionellosis_Homo sapiens_hsa051341.43890141
46Tyrosine metabolism_Homo sapiens_hsa003501.40771503
47Fatty acid elongation_Homo sapiens_hsa000621.40431919
48p53 signaling pathway_Homo sapiens_hsa041151.38078082
49Fanconi anemia pathway_Homo sapiens_hsa034601.36642465
50Pyrimidine metabolism_Homo sapiens_hsa002401.35021381
51Antigen processing and presentation_Homo sapiens_hsa046121.33651298
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31479898
53Chemical carcinogenesis_Homo sapiens_hsa052041.31290246
54Caffeine metabolism_Homo sapiens_hsa002321.30819278
55Thyroid cancer_Homo sapiens_hsa052161.25884743
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.25623658
57Bile secretion_Homo sapiens_hsa049761.24729584
58Histidine metabolism_Homo sapiens_hsa003401.22598580
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20716700
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.19247355
61Shigellosis_Homo sapiens_hsa051311.18081605
62Sulfur metabolism_Homo sapiens_hsa009201.17564775
63Systemic lupus erythematosus_Homo sapiens_hsa053221.15916576
64Asthma_Homo sapiens_hsa053101.14583662
65Drug metabolism - other enzymes_Homo sapiens_hsa009831.13616237
66Herpes simplex infection_Homo sapiens_hsa051681.13281793
67Fatty acid biosynthesis_Homo sapiens_hsa000611.11480855
68Steroid hormone biosynthesis_Homo sapiens_hsa001401.10988743
69Selenocompound metabolism_Homo sapiens_hsa004501.09282605
70Fat digestion and absorption_Homo sapiens_hsa049751.08074883
71Viral carcinogenesis_Homo sapiens_hsa052031.07488353
72Arginine and proline metabolism_Homo sapiens_hsa003301.07454465
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05489100
74Other glycan degradation_Homo sapiens_hsa005111.04450467
75Epstein-Barr virus infection_Homo sapiens_hsa051691.03519138
76Staphylococcus aureus infection_Homo sapiens_hsa051501.03127139
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02782794
78Retinol metabolism_Homo sapiens_hsa008301.02669736
79Influenza A_Homo sapiens_hsa051640.98947968
80mRNA surveillance pathway_Homo sapiens_hsa030150.97977500
81Viral myocarditis_Homo sapiens_hsa054160.97504797
82Measles_Homo sapiens_hsa051620.97104724
83Graft-versus-host disease_Homo sapiens_hsa053320.96343732
84RNA degradation_Homo sapiens_hsa030180.95388203
85Fructose and mannose metabolism_Homo sapiens_hsa000510.93597244
86Pancreatic cancer_Homo sapiens_hsa052120.91619979
87RNA polymerase_Homo sapiens_hsa030200.90076035
88B cell receptor signaling pathway_Homo sapiens_hsa046620.88696763
89Tuberculosis_Homo sapiens_hsa051520.88213361
90ABC transporters_Homo sapiens_hsa020100.87943318
91Chronic myeloid leukemia_Homo sapiens_hsa052200.87601163
92Allograft rejection_Homo sapiens_hsa053300.86724929
93Cardiac muscle contraction_Homo sapiens_hsa042600.86444237
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86313955
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86166861
96Autoimmune thyroid disease_Homo sapiens_hsa053200.84605599
97Primary immunodeficiency_Homo sapiens_hsa053400.83880878
98* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83451487
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81436967
100Acute myeloid leukemia_Homo sapiens_hsa052210.79332373
101Toxoplasmosis_Homo sapiens_hsa051450.78749080
102Apoptosis_Homo sapiens_hsa042100.78522336
103Glycerolipid metabolism_Homo sapiens_hsa005610.77933989
104Basal transcription factors_Homo sapiens_hsa030220.77625879
105Hepatitis B_Homo sapiens_hsa051610.77296508
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.75424150
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75288962
108Lysine degradation_Homo sapiens_hsa003100.74704827
109Insulin resistance_Homo sapiens_hsa049310.74172858
110Glucagon signaling pathway_Homo sapiens_hsa049220.74109823
111Hematopoietic cell lineage_Homo sapiens_hsa046400.72663964
112Small cell lung cancer_Homo sapiens_hsa052220.71973005
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71686184
114Sulfur relay system_Homo sapiens_hsa041220.68793451
115HTLV-I infection_Homo sapiens_hsa051660.68425556
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68244692
117Bladder cancer_Homo sapiens_hsa052190.67995884
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67502658
119Folate biosynthesis_Homo sapiens_hsa007900.67436066
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67429125
121Osteoclast differentiation_Homo sapiens_hsa043800.67353288
122N-Glycan biosynthesis_Homo sapiens_hsa005100.66923620
123* Pentose phosphate pathway_Homo sapiens_hsa000300.66863467
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66743568
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65134475
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.64412645
127Parkinsons disease_Homo sapiens_hsa050120.63956368
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63636384
129Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63626345
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63468971
131* Galactose metabolism_Homo sapiens_hsa000520.62204565
132Protein export_Homo sapiens_hsa030600.61483425
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60520819
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.60193845
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59267185
136Non-small cell lung cancer_Homo sapiens_hsa052230.59213242
137Oxidative phosphorylation_Homo sapiens_hsa001900.57708070
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57153973
139Dilated cardiomyopathy_Homo sapiens_hsa054140.56758539
140Cyanoamino acid metabolism_Homo sapiens_hsa004600.55800459
141AMPK signaling pathway_Homo sapiens_hsa041520.53790063
142Salmonella infection_Homo sapiens_hsa051320.51776827
143Insulin signaling pathway_Homo sapiens_hsa049100.50467780
144* Metabolic pathways_Homo sapiens_hsa011000.49186970
145Malaria_Homo sapiens_hsa051440.48843529
146Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48245375
147Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47953840
148Steroid biosynthesis_Homo sapiens_hsa001000.47366781
149Phagosome_Homo sapiens_hsa041450.47176038
150Renal cell carcinoma_Homo sapiens_hsa052110.47046582
151Vitamin B6 metabolism_Homo sapiens_hsa007500.46079840
152Central carbon metabolism in cancer_Homo sapiens_hsa052300.45481902
153Platelet activation_Homo sapiens_hsa046110.42372820
154Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42334434
155Glutathione metabolism_Homo sapiens_hsa004800.41972121
156Maturity onset diabetes of the young_Homo sapiens_hsa049500.40651637
157Vitamin digestion and absorption_Homo sapiens_hsa049770.39707935
158Alzheimers disease_Homo sapiens_hsa050100.39433283
159Type I diabetes mellitus_Homo sapiens_hsa049400.38877144
160Colorectal cancer_Homo sapiens_hsa052100.38827441
161Hepatitis C_Homo sapiens_hsa051600.37358128
162Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37053392
163One carbon pool by folate_Homo sapiens_hsa006700.22933238
164Prion diseases_Homo sapiens_hsa050200.13023848
165Glycerophospholipid metabolism_Homo sapiens_hsa005640.12478140
166Huntingtons disease_Homo sapiens_hsa050160.11276553
167Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10077195
168Circadian rhythm_Homo sapiens_hsa047100.09486829
169Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.08477250
170alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.07756981
171HIF-1 signaling pathway_Homo sapiens_hsa040660.04144099
172Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.03271483
173Longevity regulating pathway - mammal_Homo sapiens_hsa042110.01786658
174Amoebiasis_Homo sapiens_hsa05146-0.1273532
175Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0989675
176Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0872422
177cGMP-PKG signaling pathway_Homo sapiens_hsa04022-0.0714514
178Linoleic acid metabolism_Homo sapiens_hsa00591-0.0497091
179Type II diabetes mellitus_Homo sapiens_hsa04930-0.0170163

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