ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.68878757
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.77376005
3	nonmotile primary cilium assembly (GO:0035058)	3.70248787
4	fucose catabolic process (GO:0019317)	3.60074649
5	L-fucose metabolic process (GO:0042354)	3.60074649
6	L-fucose catabolic process (GO:0042355)	3.60074649
7	kynurenine metabolic process (GO:0070189)	3.44293394
8	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.41126258
9	indolalkylamine metabolic process (GO:0006586)	3.39779978
10	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.35156555
11	protein polyglutamylation (GO:0018095)	3.34952264
12	pyrimidine nucleobase catabolic process (GO:0006208)	3.33303812
13	tryptophan catabolic process (GO:0006569)	3.31243853
14	indole-containing compound catabolic process (GO:0042436)	3.31243853
15	indolalkylamine catabolic process (GO:0046218)	3.31243853
16	epithelial cilium movement (GO:0003351)	3.28539864
17	detection of light stimulus involved in visual perception (GO:0050908)	3.26990751
18	detection of light stimulus involved in sensory perception (GO:0050962)	3.26990751
19	response to pheromone (GO:0019236)	3.26014658
20	gamma-aminobutyric acid transport (GO:0015812)	3.15411840
21	establishment of protein localization to Golgi (GO:0072600)	3.13426448
22	neuronal action potential (GO:0019228)	3.11055578
23	cell proliferation in forebrain (GO:0021846)	3.08499107
24	neural tube formation (GO:0001841)	3.06810472
25	axoneme assembly (GO:0035082)	2.99215437
26	cilium or flagellum-dependent cell motility (GO:0001539)	2.99199921
27	photoreceptor cell maintenance (GO:0045494)	2.98831440
28	membrane depolarization during action potential (GO:0086010)	2.97692792
29	transmission of nerve impulse (GO:0019226)	2.97615638
30	cilium movement (GO:0003341)	2.96253945
31	regulation of cilium movement (GO:0003352)	2.92166698
32	serotonin metabolic process (GO:0042428)	2.90755267
33	regulation of action potential (GO:0098900)	2.87469408
34	nucleobase catabolic process (GO:0046113)	2.85335320
35	regulation of hippo signaling (GO:0035330)	2.84363982
36	synaptic transmission, cholinergic (GO:0007271)	2.83646627
37	behavioral response to ethanol (GO:0048149)	2.83040480
38	cilium organization (GO:0044782)	2.82877539
39	indole-containing compound metabolic process (GO:0042430)	2.81715783
40	regulation of posttranscriptional gene silencing (GO:0060147)	2.80094885
41	regulation of gene silencing by miRNA (GO:0060964)	2.80094885
42	regulation of gene silencing by RNA (GO:0060966)	2.80094885
43	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.79949950
44	axon ensheathment in central nervous system (GO:0032291)	2.78601770
45	central nervous system myelination (GO:0022010)	2.78601770
46	head development (GO:0060322)	2.78001388
47	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.77648680
48	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.77648680
49	regulation of translation, ncRNA-mediated (GO:0045974)	2.77648680
50	cilium morphogenesis (GO:0060271)	2.77610394
51	tryptophan metabolic process (GO:0006568)	2.77192953
52	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.76933715
53	cilium assembly (GO:0042384)	2.76445747
54	regulation of sarcomere organization (GO:0060297)	2.76325904
55	snRNA transcription (GO:0009301)	2.75773500
56	primary amino compound metabolic process (GO:1901160)	2.75696317
57	postsynaptic membrane organization (GO:0001941)	2.72600137
58	negative regulation of systemic arterial blood pressure (GO:0003085)	2.71805880
59	somite development (GO:0061053)	2.69611470
60	neuronal action potential propagation (GO:0019227)	2.65792126
61	nephron tubule morphogenesis (GO:0072078)	2.65684309
62	nephron epithelium morphogenesis (GO:0072088)	2.65684309
63	limb development (GO:0060173)	2.63244165
64	appendage development (GO:0048736)	2.63244165
65	protein localization to cilium (GO:0061512)	2.61806851
66	dendritic spine morphogenesis (GO:0060997)	2.60718804
67	oxidative demethylation (GO:0070989)	2.60665832
68	startle response (GO:0001964)	2.59289716
69	intraciliary transport (GO:0042073)	2.58677020
70	positive regulation of action potential (GO:0045760)	2.57462470
71	photoreceptor cell development (GO:0042461)	2.57404085
72	auditory receptor cell differentiation (GO:0042491)	2.54934937
73	negative regulation of response to food (GO:0032096)	2.54138861
74	negative regulation of appetite (GO:0032099)	2.54138861
75	synaptic transmission, glutamatergic (GO:0035249)	2.53299268
76	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.52972933
77	cellular biogenic amine catabolic process (GO:0042402)	2.52696942
78	amine catabolic process (GO:0009310)	2.52696942
79	sulfation (GO:0051923)	2.52403804
80	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.52165677
81	cellular ketone body metabolic process (GO:0046950)	2.49363514
82	reflex (GO:0060004)	2.49032400
83	retinal cone cell development (GO:0046549)	2.48662536
84	cardiovascular system development (GO:0072358)	2.47565599
85	water-soluble vitamin biosynthetic process (GO:0042364)	2.47008611
86	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.46935606
87	parturition (GO:0007567)	2.45932383
88	action potential (GO:0001508)	2.45006669
89	sperm motility (GO:0030317)	2.44153424
90	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.43578691
91	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.43578691
92	NADH dehydrogenase complex assembly (GO:0010257)	2.43578691
93	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.43318732
94	positive regulation of developmental pigmentation (GO:0048087)	2.42941262
95	retinal ganglion cell axon guidance (GO:0031290)	2.41450153
96	negative regulation of telomere maintenance (GO:0032205)	2.41444191
97	cAMP catabolic process (GO:0006198)	2.41167282
98	protein localization to synapse (GO:0035418)	2.40538979
99	DNA methylation involved in gamete generation (GO:0043046)	2.39546464
100	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.39398987

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.91343700
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.13838981
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.10687588
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.64018567
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.58447653
6	* VDR_22108803_ChIP-Seq_LS180_Human	2.53428605
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.37474806
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.26030465
9	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.12640749
10	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04135314
11	TAF15_26573619_Chip-Seq_HEK293_Human	1.96517410
12	P300_19829295_ChIP-Seq_ESCs_Human	1.92128037
13	REST_21632747_ChIP-Seq_MESCs_Mouse	1.90355053
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.87549127
15	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.85797277
16	FUS_26573619_Chip-Seq_HEK293_Human	1.80523393
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.80044722
18	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.79557735
19	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.74501396
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.67578539
21	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.67215095
22	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.67215095
23	STAT3_23295773_ChIP-Seq_U87_Human	1.65953179
24	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.65802156
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.64907790
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.63844274
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.62860721
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.61327062
29	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.61268430
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.61235757
31	* EWS_26573619_Chip-Seq_HEK293_Human	1.58660295
32	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.58613791
33	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.56802414
34	DROSHA_22980978_ChIP-Seq_HELA_Human	1.56764911
35	AR_21572438_ChIP-Seq_LNCaP_Human	1.55304373
36	TCF4_23295773_ChIP-Seq_U87_Human	1.55037153
37	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.53551329
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51991710
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51723627
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.49601853
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.49058335
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49058335
43	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.48972923
44	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.48426576
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43586929
46	AR_25329375_ChIP-Seq_VCAP_Human	1.42802227
47	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.42388605
48	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.42330875
49	RNF2_27304074_Chip-Seq_NSC_Mouse	1.41253077
50	* BCAT_22108803_ChIP-Seq_LS180_Human	1.39358276
51	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.37350038
52	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.36561442
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35332351
54	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.33086243
55	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.32969459
56	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.31886274
57	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.31564635
58	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.30103860
59	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.29633589
60	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.24645082
61	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.23513837
62	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.23146329
63	TP53_22573176_ChIP-Seq_HFKS_Human	1.22942368
64	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.22595365
65	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18984159
66	* TCF4_22108803_ChIP-Seq_LS180_Human	1.18756826
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18733887
68	TP53_16413492_ChIP-PET_HCT116_Human	1.18476326
69	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.16978140
70	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.16875421
71	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.15633970
72	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.15529501
73	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.15136517
74	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.14687780
75	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13311700
76	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13282837
77	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12635965
78	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.12533574
79	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.10518579
80	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09711473
81	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.09135640
82	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.07798236
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06300402
84	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06250102
85	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06250102
86	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06109595
87	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04720757
88	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04106532
89	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03805097
90	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.03626622
91	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.02650113
92	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.02495660
93	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.01708773
94	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.01369918
95	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.01271431
96	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.01271431
97	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.01170124
98	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.01068667
99	NCOR_22424771_ChIP-Seq_293T_Human	1.00859574
100	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99004808

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	3.31329964
2	MP0006292_abnormal_olfactory_placode	3.18348536
3	MP0008877_abnormal_DNA_methylation	2.67515267
4	MP0000569_abnormal_digit_pigmentation	2.54504913
5	MP0005551_abnormal_eye_electrophysiolog	2.36738859
6	MP0002653_abnormal_ependyma_morphology	2.34627191
7	MP0006276_abnormal_autonomic_nervous	2.17907585
8	MP0001968_abnormal_touch/_nociception	2.15943776
9	MP0003136_yellow_coat_color	2.13924682
10	MP0003646_muscle_fatigue	2.12916980
11	MP0009046_muscle_twitch	2.01764805
12	MP0003195_calcinosis	1.99807600
13	MP0003880_abnormal_central_pattern	1.95743316
14	MP0001485_abnormal_pinna_reflex	1.93495789
15	MP0005646_abnormal_pituitary_gland	1.90905945
16	MP0002272_abnormal_nervous_system	1.89870250
17	MP0009745_abnormal_behavioral_response	1.89247190
18	MP0004142_abnormal_muscle_tone	1.87730460
19	MP0002837_dystrophic_cardiac_calcinosis	1.83765075
20	MP0001984_abnormal_olfaction	1.80230057
21	MP0002102_abnormal_ear_morphology	1.78680399
22	MP0004885_abnormal_endolymph	1.77132008
23	MP0002736_abnormal_nociception_after	1.73739429
24	MP0004133_heterotaxia	1.72156168
25	MP0003121_genomic_imprinting	1.70396203
26	MP0001486_abnormal_startle_reflex	1.69997104
27	MP0000778_abnormal_nervous_system	1.66394958
28	MP0003635_abnormal_synaptic_transmissio	1.63206561
29	MP0006072_abnormal_retinal_apoptosis	1.59305825
30	MP0002572_abnormal_emotion/affect_behav	1.58055662
31	MP0002638_abnormal_pupillary_reflex	1.57432165
32	MP0002876_abnormal_thyroid_physiology	1.55506365
33	MP0004043_abnormal_pH_regulation	1.53320719
34	MP0002557_abnormal_social/conspecific_i	1.48497009
35	MP0004145_abnormal_muscle_electrophysio	1.47191881
36	MP0000631_abnormal_neuroendocrine_gland	1.46750260
37	MP0001986_abnormal_taste_sensitivity	1.46139833
38	MP0008789_abnormal_olfactory_epithelium	1.45472161
39	MP0002064_seizures	1.45107853
40	MP0001501_abnormal_sleep_pattern	1.42622456
41	MP0003122_maternal_imprinting	1.42605859
42	MP0000427_abnormal_hair_cycle	1.40675744
43	MP0002063_abnormal_learning/memory/cond	1.40374720
44	MP0002733_abnormal_thermal_nociception	1.40236499
45	MP0008872_abnormal_physiological_respon	1.40075019
46	MP0002735_abnormal_chemical_nociception	1.39727393
47	MP0001970_abnormal_pain_threshold	1.39472267
48	MP0005253_abnormal_eye_physiology	1.37358121
49	MP0003878_abnormal_ear_physiology	1.35786576
50	MP0005377_hearing/vestibular/ear_phenot	1.35786576
51	MP0005645_abnormal_hypothalamus_physiol	1.35191842
52	MP0005423_abnormal_somatic_nervous	1.34290340
53	MP0002067_abnormal_sensory_capabilities	1.33167496
54	MP0003879_abnormal_hair_cell	1.32978125
55	MP0003890_abnormal_embryonic-extraembry	1.31892980
56	MP0002184_abnormal_innervation	1.30618307
57	MP0005499_abnormal_olfactory_system	1.28604594
58	MP0005394_taste/olfaction_phenotype	1.28604594
59	MP0002163_abnormal_gland_morphology	1.26568225
60	MP0004742_abnormal_vestibular_system	1.25225277
61	MP0002938_white_spotting	1.23459923
62	MP0005195_abnormal_posterior_eye	1.23109618
63	MP0005174_abnormal_tail_pigmentation	1.22704435
64	MP0002734_abnormal_mechanical_nocicepti	1.22548946
65	MP0002752_abnormal_somatic_nervous	1.21273883
66	MP0002928_abnormal_bile_duct	1.18119855
67	MP0000955_abnormal_spinal_cord	1.15484894
68	MP0004859_abnormal_synaptic_plasticity	1.14179403
69	MP0000026_abnormal_inner_ear	1.13381055
70	MP0002160_abnormal_reproductive_system	1.12499196
71	MP0004924_abnormal_behavior	1.09146899
72	MP0005386_behavior/neurological_phenoty	1.09146899
73	MP0001440_abnormal_grooming_behavior	1.07487036
74	MP0002882_abnormal_neuron_morphology	1.07250429
75	MP0010386_abnormal_urinary_bladder	1.05343476
76	MP0001963_abnormal_hearing_physiology	1.03322188
77	MP0002234_abnormal_pharynx_morphology	1.01326428
78	MP0003011_delayed_dark_adaptation	0.97597227
79	MP0002229_neurodegeneration	0.97392149
80	MP0001188_hyperpigmentation	0.97142935
81	MP0000230_abnormal_systemic_arterial	0.95535967
82	MP0002095_abnormal_skin_pigmentation	0.95481446
83	MP0005389_reproductive_system_phenotype	0.93904653
84	MP0000372_irregular_coat_pigmentation	0.93370869
85	MP0001529_abnormal_vocalization	0.90142316
86	MP0004147_increased_porphyrin_level	0.90112540
87	MP0001293_anophthalmia	0.89370189
88	MP0009379_abnormal_foot_pigmentation	0.88602058
89	MP0001905_abnormal_dopamine_level	0.86693507
90	MP0000049_abnormal_middle_ear	0.84737158
91	MP0003698_abnormal_male_reproductive	0.83605878
92	MP0008875_abnormal_xenobiotic_pharmacok	0.82559407
93	MP0003119_abnormal_digestive_system	0.81647439
94	MP0001324_abnormal_eye_pigmentation	0.79980735
95	MP0001502_abnormal_circadian_rhythm	0.79933355
96	MP0005379_endocrine/exocrine_gland_phen	0.79244574
97	MP0005410_abnormal_fertilization	0.78970672
98	MP0002152_abnormal_brain_morphology	0.76672516
99	MP0002210_abnormal_sex_determination	0.74805671
100	MP0004130_abnormal_muscle_cell	0.74385899

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	4.67683191
2	Pancreatic cysts (HP:0001737)	4.53584504
3	Molar tooth sign on MRI (HP:0002419)	4.42623119
4	Abnormality of midbrain morphology (HP:0002418)	4.42623119
5	Nephronophthisis (HP:0000090)	4.13677077
6	True hermaphroditism (HP:0010459)	4.04997086
7	Hyperventilation (HP:0002883)	3.74531368
8	Abnormality of the renal medulla (HP:0100957)	3.68607658
9	Medial flaring of the eyebrow (HP:0010747)	3.56957794
10	Congenital stationary night blindness (HP:0007642)	3.45426080
11	Genetic anticipation (HP:0003743)	3.36872710
12	Abnormality of the renal cortex (HP:0011035)	3.23220763
13	Cystic liver disease (HP:0006706)	3.19315111
14	Chronic hepatic failure (HP:0100626)	3.18345007
15	Gait imbalance (HP:0002141)	3.15018533
16	Progressive cerebellar ataxia (HP:0002073)	3.13644186
17	Congenital primary aphakia (HP:0007707)	2.96612028
18	Tubular atrophy (HP:0000092)	2.93219723
19	Nephrogenic diabetes insipidus (HP:0009806)	2.83027251
20	Type II lissencephaly (HP:0007260)	2.78140374
21	Sclerocornea (HP:0000647)	2.76710060
22	Polydipsia (HP:0001959)	2.71071388
23	Abnormal drinking behavior (HP:0030082)	2.71071388
24	Protruding tongue (HP:0010808)	2.67761698
25	Gaze-evoked nystagmus (HP:0000640)	2.65427809
26	Attenuation of retinal blood vessels (HP:0007843)	2.62988260
27	Abolished electroretinogram (ERG) (HP:0000550)	2.60057475
28	Congenital hepatic fibrosis (HP:0002612)	2.54653119
29	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.50931326
30	Genital tract atresia (HP:0001827)	2.48961192
31	Broad-based gait (HP:0002136)	2.47074151
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.46207458
33	Vaginal atresia (HP:0000148)	2.41838722
34	Anencephaly (HP:0002323)	2.38105863
35	Poor coordination (HP:0002370)	2.37692443
36	Focal seizures (HP:0007359)	2.36749212
37	Febrile seizures (HP:0002373)	2.36587516
38	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.35298972
39	Bony spicule pigmentary retinopathy (HP:0007737)	2.34427344
40	Postaxial foot polydactyly (HP:0001830)	2.33078736
41	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.31065744
42	Lissencephaly (HP:0001339)	2.27106689
43	Cerebellar dysplasia (HP:0007033)	2.22704609
44	Decreased circulating renin level (HP:0003351)	2.22698240
45	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.21364777
46	Absent/shortened dynein arms (HP:0200106)	2.21364777
47	Polyuria (HP:0000103)	2.19287852
48	Oligodactyly (hands) (HP:0001180)	2.16104498
49	Rib fusion (HP:0000902)	2.15217187
50	Abnormality of the labia minora (HP:0012880)	2.13170309
51	Epileptic encephalopathy (HP:0200134)	2.11625989
52	Clumsiness (HP:0002312)	2.10697187
53	Abnormal pancreas size (HP:0012094)	2.10172478
54	Anophthalmia (HP:0000528)	2.08833387
55	Drooling (HP:0002307)	2.08019291
56	Renal cortical cysts (HP:0000803)	2.06314678
57	Male pseudohermaphroditism (HP:0000037)	2.05889247
58	Patellar aplasia (HP:0006443)	2.03838215
59	Optic nerve hypoplasia (HP:0000609)	2.03046330
60	Thyroid-stimulating hormone excess (HP:0002925)	2.02887604
61	Pachygyria (HP:0001302)	2.02185769
62	Pendular nystagmus (HP:0012043)	1.97582414
63	Narrow forehead (HP:0000341)	1.97475926
64	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.96894043
65	Preaxial hand polydactyly (HP:0001177)	1.96156810
66	Tachypnea (HP:0002789)	1.95628952
67	Postaxial hand polydactyly (HP:0001162)	1.95225865
68	Abnormal ciliary motility (HP:0012262)	1.94457572
69	Dialeptic seizures (HP:0011146)	1.92859682
70	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.92608878
71	Aplasia/Hypoplasia of the patella (HP:0006498)	1.92590768
72	Furrowed tongue (HP:0000221)	1.90628304
73	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.88930414
74	Inability to walk (HP:0002540)	1.88429355
75	Decreased central vision (HP:0007663)	1.87657171
76	Enlarged kidneys (HP:0000105)	1.86735333
77	Septo-optic dysplasia (HP:0100842)	1.85992624
78	Absent speech (HP:0001344)	1.85183528
79	Agitation (HP:0000713)	1.84475684
80	Focal motor seizures (HP:0011153)	1.83556456
81	Excessive salivation (HP:0003781)	1.83288078
82	Tubulointerstitial nephritis (HP:0001970)	1.82360530
83	Specific learning disability (HP:0001328)	1.82143793
84	Atonic seizures (HP:0010819)	1.81968379
85	Short foot (HP:0001773)	1.79981135
86	Keratoconus (HP:0000563)	1.79794337
87	Increased corneal curvature (HP:0100692)	1.79794337
88	Occipital encephalocele (HP:0002085)	1.79464162
89	Ectopic kidney (HP:0000086)	1.78946095
90	Highly arched eyebrow (HP:0002553)	1.78046326
91	Hyperalaninemia (HP:0003348)	1.77575609
92	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.77575609
93	Abnormality of alanine metabolism (HP:0010916)	1.77575609
94	Polyphagia (HP:0002591)	1.77340062
95	Aganglionic megacolon (HP:0002251)	1.76067016
96	Asplenia (HP:0001746)	1.75907353
97	Abnormal respiratory motile cilium morphology (HP:0005938)	1.75634869
98	Abnormal respiratory epithelium morphology (HP:0012253)	1.75634869
99	Retinitis pigmentosa (HP:0000510)	1.73679421
100	Abnormal urine output (HP:0012590)	1.73258258

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.84644462
2	ADRBK2	2.77404751
3	BMPR1B	2.50802408
4	CASK	2.50013469
5	WNK4	2.48678655
6	TAOK3	2.30502724
7	WNK3	2.16925892
8	PINK1	2.15076352
9	ACVR1B	2.10260944
10	GRK1	2.04531104
11	NUAK1	2.03483158
12	INSRR	2.02489498
13	MAP3K4	2.02357793
14	MAP4K2	1.99516077
15	MAPK13	1.93441883
16	STK39	1.75324022
17	NTRK3	1.69345107
18	ZAK	1.69050914
19	MARK1	1.63429767
20	PAK3	1.61759556
21	TNIK	1.58513718
22	NTRK2	1.55489696
23	TLK1	1.40322240
24	OXSR1	1.38596358
25	AKT3	1.27168049
26	ADRBK1	1.25621345
27	DYRK2	1.24128207
28	MAP2K7	1.21921586
29	PRKCG	1.21008902
30	DAPK2	1.18985680
31	PIK3CA	1.07167033
32	SIK2	1.05997699
33	MKNK2	1.03932806
34	PNCK	1.01093759
35	CAMK1	0.99628756
36	EPHA4	0.96136777
37	SGK494	0.91430667
38	SGK223	0.91430667
39	SGK2	0.90020343
40	PRKCE	0.87592674
41	STK11	0.84043152
42	WNK1	0.83079920
43	CAMK1G	0.80950565
44	PLK4	0.79722416
45	OBSCN	0.78225236
46	STK38L	0.76093918
47	PTK2B	0.74916301
48	TEC	0.74713740
49	PLK2	0.74690213
50	PKN1	0.74480843
51	TIE1	0.74322641
52	MAPK15	0.72793810
53	CAMK2A	0.68610300
54	CDK19	0.66853884
55	TNK2	0.66407238
56	TRIM28	0.66359396
57	STK3	0.65898139
58	TXK	0.65563779
59	MUSK	0.64546777
60	TYRO3	0.63411043
61	MARK2	0.62891377
62	CAMK1D	0.60956591
63	MAP3K7	0.60932969
64	CAMKK2	0.60300551
65	PRKACA	0.59626373
66	PRKCH	0.58944911
67	MINK1	0.56768074
68	PHKG2	0.55634127
69	PHKG1	0.55634127
70	MAP2K4	0.55170678
71	CSNK1G2	0.54316928
72	DMPK	0.53228018
73	PRKCQ	0.52981590
74	SGK1	0.52531457
75	BCKDK	0.52096954
76	PRKCZ	0.51020174
77	ERBB2	0.50060653
78	FGFR2	0.49204541
79	CAMK4	0.47328890
80	DYRK1A	0.46876327
81	PRKG1	0.46345968
82	CSNK1A1	0.45977097
83	PRKAA1	0.45564033
84	TGFBR1	0.44370327
85	CDC7	0.44075414
86	PRKAA2	0.42421873
87	CSNK1D	0.41236340
88	CDK5	0.41061228
89	PIK3CG	0.40213748
90	PRKCA	0.39048517
91	RPS6KA3	0.38804768
92	CSNK1E	0.38650938
93	PRKCI	0.38157670
94	MARK3	0.38083285
95	CHUK	0.37870324
96	STK16	0.36176058
97	CSNK1A1L	0.34634890
98	PRKACB	0.33766032
99	GRK7	0.33380808
100	AKT1	0.31828445

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.24348821
2	Phototransduction_Homo sapiens_hsa04744	2.96397146
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.31587800
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.22641995
5	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.19410846
6	Morphine addiction_Homo sapiens_hsa05032	2.09942252
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.04167479
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.02927455
9	Butanoate metabolism_Homo sapiens_hsa00650	1.99590160
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.95939394
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.92081123
12	Taste transduction_Homo sapiens_hsa04742	1.88225221
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.86350330
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.84661167
15	Insulin secretion_Homo sapiens_hsa04911	1.78142586
16	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.72953671
17	Circadian entrainment_Homo sapiens_hsa04713	1.71372498
18	Glutamatergic synapse_Homo sapiens_hsa04724	1.71205436
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.70083155
20	GABAergic synapse_Homo sapiens_hsa04727	1.68595999
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.67686496
22	Olfactory transduction_Homo sapiens_hsa04740	1.62222025
23	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.58238035
24	Homologous recombination_Homo sapiens_hsa03440	1.57857870
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.50528824
26	Oxidative phosphorylation_Homo sapiens_hsa00190	1.49729774
27	ABC transporters_Homo sapiens_hsa02010	1.44860861
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.43726120
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.41647265
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.40000003
31	Serotonergic synapse_Homo sapiens_hsa04726	1.38909967
32	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.38216619
33	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.36068615
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.31744225
35	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.31701288
36	Salivary secretion_Homo sapiens_hsa04970	1.19307629
37	Calcium signaling pathway_Homo sapiens_hsa04020	1.17817963
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.17124120
39	Basal transcription factors_Homo sapiens_hsa03022	1.14338009
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.13323657
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.12819078
42	Dopaminergic synapse_Homo sapiens_hsa04728	1.12479859
43	Retinol metabolism_Homo sapiens_hsa00830	1.07477995
44	Caffeine metabolism_Homo sapiens_hsa00232	1.07199534
45	Propanoate metabolism_Homo sapiens_hsa00640	1.07189371
46	Parkinsons disease_Homo sapiens_hsa05012	1.04450252
47	Cholinergic synapse_Homo sapiens_hsa04725	1.04435365
48	RNA polymerase_Homo sapiens_hsa03020	1.04032712
49	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.01091283
50	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.00866509
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.99631126
52	Huntingtons disease_Homo sapiens_hsa05016	0.96402741
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.94183603
54	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.93908824
55	Glycerolipid metabolism_Homo sapiens_hsa00561	0.90891857
56	Regulation of autophagy_Homo sapiens_hsa04140	0.89042588
57	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.87912823
58	Peroxisome_Homo sapiens_hsa04146	0.87272901
59	Long-term depression_Homo sapiens_hsa04730	0.87038705
60	Axon guidance_Homo sapiens_hsa04360	0.81926228
61	Cocaine addiction_Homo sapiens_hsa05030	0.81663690
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.80441104
63	Gastric acid secretion_Homo sapiens_hsa04971	0.80029533
64	cAMP signaling pathway_Homo sapiens_hsa04024	0.79733490
65	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.77785628
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.76442109
67	Alzheimers disease_Homo sapiens_hsa05010	0.76195302
68	Protein export_Homo sapiens_hsa03060	0.74337896
69	RNA degradation_Homo sapiens_hsa03018	0.73594484
70	Histidine metabolism_Homo sapiens_hsa00340	0.71690324
71	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.70842828
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.67779021
73	Lysine degradation_Homo sapiens_hsa00310	0.67204075
74	Renin secretion_Homo sapiens_hsa04924	0.65605191
75	Amphetamine addiction_Homo sapiens_hsa05031	0.63180780
76	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.61586825
77	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.60900684
78	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.58364834
79	Basal cell carcinoma_Homo sapiens_hsa05217	0.58177186
80	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.55487169
81	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.53522297
82	Pancreatic secretion_Homo sapiens_hsa04972	0.51451889
83	Sulfur relay system_Homo sapiens_hsa04122	0.48922193
84	Fatty acid degradation_Homo sapiens_hsa00071	0.48531891
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.48328418
86	Hippo signaling pathway_Homo sapiens_hsa04390	0.47777001
87	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.47503769
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46837557
89	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.44489369
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44223565
91	Type II diabetes mellitus_Homo sapiens_hsa04930	0.43369560
92	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.42499460
93	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.42288909
94	Steroid biosynthesis_Homo sapiens_hsa00100	0.41127664
95	Collecting duct acid secretion_Homo sapiens_hsa04966	0.40967621
96	Metabolic pathways_Homo sapiens_hsa01100	0.40088344
97	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.39103674
98	Purine metabolism_Homo sapiens_hsa00230	0.38798821
99	Mineral absorption_Homo sapiens_hsa04978	0.38241455
100	Ribosome_Homo sapiens_hsa03010	0.38039173

PGM5P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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