PGPEP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glyoxylate metabolic process (GO:0046487)5.00177060
2L-phenylalanine metabolic process (GO:0006558)4.75726662
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.75726662
4tryptophan catabolic process (GO:0006569)4.70943661
5indole-containing compound catabolic process (GO:0042436)4.70943661
6indolalkylamine catabolic process (GO:0046218)4.70943661
7aromatic amino acid family catabolic process (GO:0009074)4.68623262
8L-phenylalanine catabolic process (GO:0006559)4.67652905
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.67652905
10exogenous drug catabolic process (GO:0042738)4.60452056
11tryptophan metabolic process (GO:0006568)4.41567488
12sulfur amino acid catabolic process (GO:0000098)4.09362709
13urate metabolic process (GO:0046415)4.02979707
14serine family amino acid catabolic process (GO:0009071)4.02522590
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.99268371
16positive regulation of fatty acid beta-oxidation (GO:0032000)3.96189153
17kynurenine metabolic process (GO:0070189)3.95529913
18aldehyde catabolic process (GO:0046185)3.95283814
19amino-acid betaine metabolic process (GO:0006577)3.92640540
20urea cycle (GO:0000050)3.86333090
21urea metabolic process (GO:0019627)3.86333090
22lysine metabolic process (GO:0006553)3.85521190
23lysine catabolic process (GO:0006554)3.85521190
24drug transmembrane transport (GO:0006855)3.81089007
25bile acid biosynthetic process (GO:0006699)3.78110701
26cysteine metabolic process (GO:0006534)3.76482507
27NAD biosynthetic process (GO:0009435)3.71791688
28nitrogen cycle metabolic process (GO:0071941)3.64937785
29positive regulation of fatty acid oxidation (GO:0046321)3.58557136
30cellular glucuronidation (GO:0052695)3.57986498
31amine catabolic process (GO:0009310)3.57936584
32cellular biogenic amine catabolic process (GO:0042402)3.57936584
33drug transport (GO:0015893)3.56526028
34glycine metabolic process (GO:0006544)3.56020909
35triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.55127038
36serine family amino acid metabolic process (GO:0009069)3.51708356
37homocysteine metabolic process (GO:0050667)3.50574339
38aromatic amino acid family metabolic process (GO:0009072)3.50283628
39uronic acid metabolic process (GO:0006063)3.48381073
40glucuronate metabolic process (GO:0019585)3.48381073
41killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.47479883
42disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.47479883
43carnitine metabolic process (GO:0009437)3.45301491
44L-fucose catabolic process (GO:0042355)3.41370144
45fucose catabolic process (GO:0019317)3.41370144
46L-fucose metabolic process (GO:0042354)3.41370144
47epoxygenase P450 pathway (GO:0019373)3.40086441
48nicotinamide nucleotide biosynthetic process (GO:0019359)3.39077410
49pyridine nucleotide biosynthetic process (GO:0019363)3.39077410
50serine family amino acid biosynthetic process (GO:0009070)3.36578991
51alpha-amino acid catabolic process (GO:1901606)3.32213790
52indolalkylamine metabolic process (GO:0006586)3.28931491
53arginine metabolic process (GO:0006525)3.27292123
54intestinal cholesterol absorption (GO:0030299)3.24198463
55response to nitrosative stress (GO:0051409)3.24101817
56imidazole-containing compound metabolic process (GO:0052803)3.23728772
57valine metabolic process (GO:0006573)3.21199404
58cellular amino acid catabolic process (GO:0009063)3.20936666
59cellular modified amino acid catabolic process (GO:0042219)3.20243960
60branched-chain amino acid catabolic process (GO:0009083)3.19667805
61aminoglycoside antibiotic metabolic process (GO:0030647)3.17293010
62fatty acid beta-oxidation (GO:0006635)3.17197853
63iron coordination entity transport (GO:1901678)3.13455301
64low-density lipoprotein particle remodeling (GO:0034374)3.13383305
65negative regulation of fibrinolysis (GO:0051918)3.12941424
66branched-chain amino acid metabolic process (GO:0009081)3.12278312
67regulation of fibrinolysis (GO:0051917)3.12080751
68benzene-containing compound metabolic process (GO:0042537)3.12037504
69flavonoid metabolic process (GO:0009812)3.10431694
70interkinetic nuclear migration (GO:0022027)3.09316303
71alpha-linolenic acid metabolic process (GO:0036109)3.07942608
72regulation of cholesterol esterification (GO:0010872)3.07279525
73bile acid metabolic process (GO:0008206)3.07232243
74positive regulation of cellular amine metabolic process (GO:0033240)3.06997865
75short-chain fatty acid metabolic process (GO:0046459)3.05516104
76carboxylic acid catabolic process (GO:0046395)3.05369767
77organic acid catabolic process (GO:0016054)3.05369767
78DNA deamination (GO:0045006)3.02587496
79mannose metabolic process (GO:0006013)3.01464818
80protein carboxylation (GO:0018214)3.00516146
81peptidyl-glutamic acid carboxylation (GO:0017187)3.00516146
82intestinal absorption (GO:0050892)2.98742989
83killing of cells of other organism (GO:0031640)2.98491071
84disruption of cells of other organism (GO:0044364)2.98491071
85high-density lipoprotein particle remodeling (GO:0034375)2.97112382
86fatty acid oxidation (GO:0019395)2.96712187
87fatty acid catabolic process (GO:0009062)2.95964583
88xenobiotic catabolic process (GO:0042178)2.95667148
89regulation of protein activation cascade (GO:2000257)2.94997719
90lipid oxidation (GO:0034440)2.93751297
91drug catabolic process (GO:0042737)2.93469676
92oxidative demethylation (GO:0070989)2.92551566
93arginine catabolic process (GO:0006527)2.92467904
94monocarboxylic acid catabolic process (GO:0072329)2.91226295
95macroautophagy (GO:0016236)2.90442602
96protein-lipid complex remodeling (GO:0034368)2.88085905
97macromolecular complex remodeling (GO:0034367)2.88085905
98plasma lipoprotein particle remodeling (GO:0034369)2.88085905
99proline metabolic process (GO:0006560)2.86183020
100positive regulation of lipoprotein lipase activity (GO:0051006)2.86181238
101positive regulation of triglyceride lipase activity (GO:0061365)2.86181238
102regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.84267872
103regulation of complement activation (GO:0030449)2.83622472
104coenzyme catabolic process (GO:0009109)2.83232491
105lipoprotein metabolic process (GO:0042157)2.81988135
106regulation of triglyceride catabolic process (GO:0010896)2.81408419
107negative regulation of cholesterol transport (GO:0032375)2.78121253
108negative regulation of sterol transport (GO:0032372)2.78121253
109phospholipid efflux (GO:0033700)2.77510096
110fatty acid transmembrane transport (GO:1902001)2.76831503
111plasma lipoprotein particle organization (GO:0071827)2.75850735
112drug metabolic process (GO:0017144)2.75766278
113positive regulation of lipid catabolic process (GO:0050996)2.72675488
114ketone body metabolic process (GO:1902224)2.72226928
115reverse cholesterol transport (GO:0043691)2.72043641
116bile acid and bile salt transport (GO:0015721)2.71674192
117cholesterol efflux (GO:0033344)2.71561175
118regulation of fatty acid beta-oxidation (GO:0031998)2.71501641
119blood coagulation, intrinsic pathway (GO:0007597)2.71312490
120cofactor catabolic process (GO:0051187)2.69371154
121tricarboxylic acid metabolic process (GO:0072350)2.68701124
122cellular ketone body metabolic process (GO:0046950)2.68493849
123organic cation transport (GO:0015695)2.68299416
124NAD metabolic process (GO:0019674)2.68153951
125pentose metabolic process (GO:0019321)2.68005164
126phospholipid homeostasis (GO:0055091)2.67975812
127triglyceride homeostasis (GO:0070328)2.67762824
128acylglycerol homeostasis (GO:0055090)2.67762824
129very-low-density lipoprotein particle assembly (GO:0034379)2.65613822
130positive regulation of fatty acid metabolic process (GO:0045923)2.64981364
131complement activation, alternative pathway (GO:0006957)2.62326399
132protein-lipid complex subunit organization (GO:0071825)2.55301090
133cellular response to ethanol (GO:0071361)2.53374007
134sodium-independent organic anion transport (GO:0043252)2.52768604
135regulation of cholesterol homeostasis (GO:2000188)2.49384220
136plasma lipoprotein particle assembly (GO:0034377)2.48145840
137hormone catabolic process (GO:0042447)2.47348530
138omega-hydroxylase P450 pathway (GO:0097267)2.46509840
139transepithelial transport (GO:0070633)2.40452355
140negative regulation of sodium ion transport (GO:0010766)2.40286924
141plasma lipoprotein particle clearance (GO:0034381)2.39622382
142sulfation (GO:0051923)2.39315614
143alkaloid metabolic process (GO:0009820)2.37214842
144cellular response to exogenous dsRNA (GO:0071360)2.36599530
145negative regulation of fatty acid transport (GO:2000192)2.34698332
146fucosylation (GO:0036065)2.34526867
147regulation of systemic arterial blood pressure by hormone (GO:0001990)2.33656894
148regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.33656894
149endocrine process (GO:0050886)2.33656894
150regulation of female gonad development (GO:2000194)2.32840709
151regulation of hippo signaling (GO:0035330)2.31723664
152regulation of fatty acid oxidation (GO:0046320)2.28215173
153ethanol oxidation (GO:0006069)2.28120992
154alanine transport (GO:0032328)2.27811454

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.72516478
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.44156235
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.11136689
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.61186805
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.13364943
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.08321411
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.62045004
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.33505575
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.04882230
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.94487603
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.87905383
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.66926795
13EZH2_22144423_ChIP-Seq_EOC_Human2.46808498
14DROSHA_22980978_ChIP-Seq_HELA_Human2.40420038
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.30298171
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.28369978
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.17483914
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.13853733
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.09349203
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07549634
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06866735
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05746740
23SCL_19346495_ChIP-Seq_HPC-7_Human2.02137414
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99327989
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.95972919
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95096939
27ZNF274_21170338_ChIP-Seq_K562_Hela1.91143604
28VDR_22108803_ChIP-Seq_LS180_Human1.88686366
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.88578140
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.86028150
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83438092
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81521080
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79731351
34* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.77204483
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.68688107
36ERG_20887958_ChIP-Seq_HPC-7_Mouse1.66616804
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65226065
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.64634497
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.64571532
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.61154664
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56657543
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56348871
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54890512
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54245523
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53417823
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53368361
47GATA1_22025678_ChIP-Seq_K562_Human1.51769000
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51090480
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.48240832
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43532145
51* TP53_16413492_ChIP-PET_HCT116_Human1.43164311
52TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.42129340
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41960489
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41768933
55CDX2_20551321_ChIP-Seq_CACO-2_Human1.41193479
56AR_21572438_ChIP-Seq_LNCaP_Human1.34088055
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34022199
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32229212
59MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31034797
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30915931
61ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30609824
62MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.29284015
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28480117
64ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26162372
65VDR_24787735_ChIP-Seq_THP-1_Human1.26077938
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.25561391
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24701849
68PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.23636136
69RUNX_20019798_ChIP-Seq_JUKART_Human1.23161822
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23030061
71* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22984866
72GATA1_19941826_ChIP-Seq_K562_Human1.22737603
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19000364
74EST1_17652178_ChIP-ChIP_JURKAT_Human1.18461609
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18278801
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16916387
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15452638
78IRF8_21731497_ChIP-ChIP_J774_Mouse1.14941609
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14879529
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.13465023
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12794984
82HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12031601
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11840696
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08993928
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08528978
86NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07451223
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.07351911
88AR_20517297_ChIP-Seq_VCAP_Human1.06498865
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06071685
90AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06024805
91BCAT_22108803_ChIP-Seq_LS180_Human1.05504319
92GBX2_23144817_ChIP-Seq_PC3_Human1.03970057
93ERA_21632823_ChIP-Seq_H3396_Human1.03861044
94GATA4_25053715_ChIP-Seq_YYC3_Human1.03592767
95YY1_21170310_ChIP-Seq_MESCs_Mouse1.03545360
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03130787
97* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02987810
98CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02706928
99SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02409365
100VDR_21846776_ChIP-Seq_THP-1_Human1.02191852
101SPI1_23547873_ChIP-Seq_NB4_Human1.02070663
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01656771
103STAT3_23295773_ChIP-Seq_U87_Human1.01255525
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00791401
105ESR2_21235772_ChIP-Seq_MCF-7_Human0.99753976
106OCT4_20526341_ChIP-Seq_ESCs_Human0.99491410
107CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98781223
108GATA2_19941826_ChIP-Seq_K562_Human0.95594282
109RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94909211
110FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94565220
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94530770
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94461733
113* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92834381
114ER_23166858_ChIP-Seq_MCF-7_Human0.92643339
115* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92166843
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91752274
117GATA2_21666600_ChIP-Seq_HMVEC_Human0.91311831
118ARNT_22903824_ChIP-Seq_MCF-7_Human0.90458486
119ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90440230
120VDR_24763502_ChIP-Seq_THP-1_Human0.89908186
121GATA3_21867929_ChIP-Seq_CD8_Mouse0.88924201
122SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.86911174
123TDRD3_21172665_ChIP-Seq_MCF-7_Human0.86209544
124VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86050308
125P53_21459846_ChIP-Seq_SAOS-2_Human0.85559912
126FOXA1_25552417_ChIP-Seq_VCAP_Human0.85494946
127SPI1_23127762_ChIP-Seq_K562_Human0.85357449
128* CEBPB_22108803_ChIP-Seq_LS180_Human0.85188901
129SMAD3_21741376_ChIP-Seq_HESCs_Human0.85131658
130TET1_21451524_ChIP-Seq_MESCs_Mouse0.84598675
131TCF4_23295773_ChIP-Seq_U87_Human0.84335660
132CTCF_26484167_Chip-Seq_Bcells_Mouse0.84237399
133BCOR_27268052_Chip-Seq_Bcells_Human0.84179175
134CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84043866
135PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83542856
136CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83369326
137AHR_22903824_ChIP-Seq_MCF-7_Human0.83354042
138CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81839038
139RAC3_21632823_ChIP-Seq_H3396_Human0.81786765
140FOXP3_21729870_ChIP-Seq_TREG_Human0.81114971
141BRD4_27068464_Chip-Seq_AML-cells_Mouse0.81109981
142GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81017442
143TAF2_19829295_ChIP-Seq_ESCs_Human0.80499061
144DCP1A_22483619_ChIP-Seq_HELA_Human0.80447069
145EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80357055
146* IRF8_27001747_Chip-Seq_BMDM_Mouse0.80328648
147CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80067244
148* GATA3_21878914_ChIP-Seq_MCF-7_Human0.79981383
149RAD21_21589869_ChIP-Seq_MESCs_Mouse0.79516020
150LXR_22292898_ChIP-Seq_THP-1_Human0.79487436
151FOXH1_21741376_ChIP-Seq_ESCs_Human0.78628742
152FOXO3_23340844_ChIP-Seq_DLD1_Human0.78596295
153ERG_20517297_ChIP-Seq_VCAP_Human0.78078684
154* OCT1_27270436_Chip-Seq_PROSTATE_Human0.77905856
155STAT4_19710469_ChIP-ChIP_TH1__Mouse0.77815924
156PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77749615
157JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77745123
158PRDM14_20953172_ChIP-Seq_ESCs_Human0.77517430
159SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77467150
160BCL6_27268052_Chip-Seq_Bcells_Human0.77269061
161KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77010154
162EZH2_27294783_Chip-Seq_ESCs_Mouse0.76763372
163ESR1_21235772_ChIP-Seq_MCF-7_Human0.76578517
164ETS1_20019798_ChIP-Seq_JURKAT_Human0.76350695
165RXR_22108803_ChIP-Seq_LS180_Human0.76086614
166PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.75564285
167NELFA_20434984_ChIP-Seq_ESCs_Mouse0.75329413
168NANOG_18555785_ChIP-Seq_MESCs_Mouse0.75286961
169IRF1_19129219_ChIP-ChIP_H3396_Human0.75135213
170HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.74878738
171P300_27268052_Chip-Seq_Bcells_Human0.74584655
172E2F1_20622854_ChIP-Seq_HELA_Human0.74584612
173SOX2_18692474_ChIP-Seq_MEFs_Mouse0.74528262
174OCT4_19829295_ChIP-Seq_ESCs_Human0.74328321
175* HNF4A_19822575_ChIP-Seq_HepG2_Human0.74204164
176P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.74014862
177* SMAD4_21741376_ChIP-Seq_HESCs_Human0.73417930
178AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.72883861
179ZNF217_24962896_ChIP-Seq_MCF-7_Human0.72830361

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.61421330
2MP0005360_urolithiasis5.75414903
3MP0005365_abnormal_bile_salt4.08387300
4MP0005085_abnormal_gallbladder_physiolo3.99826519
5MP0003806_abnormal_nucleotide_metabolis3.56732116
6MP0008875_abnormal_xenobiotic_pharmacok3.32632259
7MP0009379_abnormal_foot_pigmentation2.94720009
8MP0005332_abnormal_amino_acid2.85395661
9MP0003252_abnormal_bile_duct2.58021591
10MP0003191_abnormal_cellular_cholesterol2.41039182
11MP0004130_abnormal_muscle_cell2.26172957
12MP0004019_abnormal_vitamin_homeostasis2.13847088
13MP0003186_abnormal_redox_activity2.10506916
14MP0010329_abnormal_lipoprotein_level2.07459072
15MP0003195_calcinosis2.06351755
16MP0002138_abnormal_hepatobiliary_system2.05024670
17MP0001666_abnormal_nutrient_absorption1.99686883
18MP0002876_abnormal_thyroid_physiology1.98890390
19MP0005174_abnormal_tail_pigmentation1.90196653
20MP0005075_abnormal_melanosome_morpholog1.89643312
21MP0003879_abnormal_hair_cell1.89240129
22MP0009840_abnormal_foam_cell1.88861967
23MP0009643_abnormal_urine_homeostasis1.86637312
24MP0005645_abnormal_hypothalamus_physiol1.80839442
25MP0005319_abnormal_enzyme/_coenzyme1.73342654
26MP0001764_abnormal_homeostasis1.72253335
27MP0003724_increased_susceptibility_to1.60626368
28MP0008872_abnormal_physiological_respon1.58866365
29MP0003011_delayed_dark_adaptation1.58811466
30MP0001501_abnormal_sleep_pattern1.58715956
31MP0005167_abnormal_blood-brain_barrier1.56683793
32MP0003045_fibrosis1.54997823
33MP0005636_abnormal_mineral_homeostasis1.52721764
34MP0003436_decreased_susceptibility_to1.50975827
35MP0005084_abnormal_gallbladder_morpholo1.50484204
36MP0004145_abnormal_muscle_electrophysio1.49040556
37MP0001835_abnormal_antigen_presentation1.45665147
38MP0003868_abnormal_feces_composition1.45426512
39MP0009697_abnormal_copulation1.44770092
40MP0000015_abnormal_ear_pigmentation1.43824559
41MP0005408_hypopigmentation1.42462674
42MP0000609_abnormal_liver_physiology1.40028858
43MP0003136_yellow_coat_color1.31850701
44MP0003646_muscle_fatigue1.27375032
45MP0009785_altered_susceptibility_to1.26558438
46MP0001853_heart_inflammation1.26169197
47MP0000569_abnormal_digit_pigmentation1.23816904
48MP0006292_abnormal_olfactory_placode1.23639289
49MP0001873_stomach_inflammation1.23633522
50MP0008469_abnormal_protein_level1.21911401
51MP0005584_abnormal_enzyme/coenzyme_acti1.20508833
52MP0009764_decreased_sensitivity_to1.19305154
53MP0002118_abnormal_lipid_homeostasis1.19294611
54MP0004381_abnormal_hair_follicle1.18493241
55MP0005409_darkened_coat_color1.15552404
56MP0008775_abnormal_heart_ventricle1.15410878
57MP0005058_abnormal_lysosome_morphology1.13539991
58MP0005083_abnormal_biliary_tract1.12029529
59MP0000371_diluted_coat_color1.11988594
60MP0002971_abnormal_brown_adipose1.11578453
61MP0005451_abnormal_body_composition1.09404260
62MP0006036_abnormal_mitochondrial_physio1.07584232
63MP0005220_abnormal_exocrine_pancreas1.06364666
64MP0005448_abnormal_energy_balance1.06192479
65MP0000566_synostosis1.05663793
66MP0000685_abnormal_immune_system1.04644594
67MP0005551_abnormal_eye_electrophysiolog1.04221915
68MP0003866_abnormal_defecation1.03759280
69MP0000678_abnormal_parathyroid_gland1.03163563
70MP0002136_abnormal_kidney_physiology1.02839782
71MP0004147_increased_porphyrin_level1.01975790
72MP0000598_abnormal_liver_morphology1.01344810
73MP0000372_irregular_coat_pigmentation1.01323082
74MP0004885_abnormal_endolymph1.01021106
75MP0009115_abnormal_fat_cell1.00395841
76MP0002933_joint_inflammation0.99276857
77MP0000230_abnormal_systemic_arterial0.98084846
78MP0001756_abnormal_urination0.98055087
79MP0005025_abnormal_response_to0.97195510
80MP0002148_abnormal_hypersensitivity_rea0.96453689
81MP0001800_abnormal_humoral_immune0.96263370
82MP0001664_abnormal_digestion0.94852704
83MP0000490_abnormal_crypts_of0.94640763
84MP0002249_abnormal_larynx_morphology0.94618990
85MP0005334_abnormal_fat_pad0.94483246
86MP0002837_dystrophic_cardiac_calcinosis0.93990805
87MP0000604_amyloidosis0.93763038
88MP0005464_abnormal_platelet_physiology0.92853258
89MP0008961_abnormal_basal_metabolism0.90290461
90MP0004084_abnormal_cardiac_muscle0.90248694
91MP0003953_abnormal_hormone_level0.89728699
92MP0004036_abnormal_muscle_relaxation0.89341862
93MP0002078_abnormal_glucose_homeostasis0.88738669
94MP0009642_abnormal_blood_homeostasis0.88681969
95MP0001986_abnormal_taste_sensitivity0.87740249
96MP0005647_abnormal_sex_gland0.87550311
97MP0002419_abnormal_innate_immunity0.86969500
98MP0004043_abnormal_pH_regulation0.86529801
99MP0001790_abnormal_immune_system0.85961875
100MP0005387_immune_system_phenotype0.85961875
101MP0000681_abnormal_thyroid_gland0.84950898
102MP0009763_increased_sensitivity_to0.81548541
103MP0002168_other_aberrant_phenotype0.81003226
104MP0001845_abnormal_inflammatory_respons0.79862375
105MP0002909_abnormal_adrenal_gland0.79049412
106MP0004782_abnormal_surfactant_physiolog0.78638248
107MP0002095_abnormal_skin_pigmentation0.77964407
108MP0004858_abnormal_nervous_system0.77643680
109MP0000249_abnormal_blood_vessel0.75851319
110MP0003632_abnormal_nervous_system0.75586306
111MP0003718_maternal_effect0.74613455
112MP0002733_abnormal_thermal_nociception0.74017231
113MP0003656_abnormal_erythrocyte_physiolo0.73888643
114MP0003283_abnormal_digestive_organ0.73807944
115MP0005670_abnormal_white_adipose0.73506905
116MP0010155_abnormal_intestine_physiology0.73279326
117MP0005376_homeostasis/metabolism_phenot0.73092832
118MP0003329_amyloid_beta_deposits0.72335496
119MP0000013_abnormal_adipose_tissue0.72283099
120MP0002075_abnormal_coat/hair_pigmentati0.71777286
121MP0003959_abnormal_lean_body0.71034462
122MP0002135_abnormal_kidney_morphology0.69881978
123MP0002089_abnormal_postnatal_growth/wei0.69717346
124MP0002396_abnormal_hematopoietic_system0.69493291
125MP0009333_abnormal_splenocyte_physiolog0.69405138
126MP0003638_abnormal_response/metabolism_0.69321851
127MP0005646_abnormal_pituitary_gland0.68745598
128MP0001502_abnormal_circadian_rhythm0.68705374
129MP0001186_pigmentation_phenotype0.68311055
130MP0002928_abnormal_bile_duct0.67571420
131MP0004142_abnormal_muscle_tone0.67508965
132MP0002723_abnormal_immune_serum0.66030609
133MP0005535_abnormal_body_temperature0.65917543
134MP0001765_abnormal_ion_homeostasis0.65778668
135MP0003183_abnormal_peptide_metabolism0.65313727
136MP0002132_abnormal_respiratory_system0.65239224
137MP0000049_abnormal_middle_ear0.65198867
138MP0002693_abnormal_pancreas_physiology0.65101077
139MP0003172_abnormal_lysosome_physiology0.64304303
140MP0010368_abnormal_lymphatic_system0.63653216
141MP0001188_hyperpigmentation0.63301618
142MP0008260_abnormal_autophagy0.62426075
143MP0000343_altered_response_to0.61626068
144MP0005595_abnormal_vascular_smooth0.61530521
145MP0003763_abnormal_thymus_physiology0.60045178
146MP0000613_abnormal_salivary_gland0.59867084
147MP0001663_abnormal_digestive_system0.58178263
148MP0009053_abnormal_anal_canal0.57063056
149MP0009384_cardiac_valve_regurgitation0.56968861
150MP0005266_abnormal_metabolism0.56021054
151MP0005671_abnormal_response_to0.55005926

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)5.85104355
2Prolonged partial thromboplastin time (HP:0003645)4.79320532
3Type I transferrin isoform profile (HP:0003642)4.72646187
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.52273255
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.47655205
6Hyperglycinuria (HP:0003108)4.02396033
7Genetic anticipation (HP:0003743)4.00937986
8Abnormality of glutamine family amino acid metabolism (HP:0010902)3.85298813
9Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.81472888
10Generalized aminoaciduria (HP:0002909)3.77339177
11Abnormality of pyrimidine metabolism (HP:0004353)3.69438883
12Abnormal protein glycosylation (HP:0012346)3.67440078
13Abnormal glycosylation (HP:0012345)3.67440078
14Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.67440078
15Abnormal protein N-linked glycosylation (HP:0012347)3.67440078
16Intrahepatic cholestasis (HP:0001406)3.62086054
17Joint hemorrhage (HP:0005261)3.45091451
18Polydipsia (HP:0001959)3.43556961
19Abnormal drinking behavior (HP:0030082)3.43556961
20Hyperglycinemia (HP:0002154)3.42671121
21Abnormality of fatty-acid metabolism (HP:0004359)3.42582024
22Abnormality of serine family amino acid metabolism (HP:0010894)3.36790166
23Abnormality of glycine metabolism (HP:0010895)3.36790166
24Increased neuronal autofluorescent lipopigment (HP:0002074)3.34293684
25Hyperammonemia (HP:0001987)3.31414119
26Congenital stationary night blindness (HP:0007642)3.26646228
27Large for gestational age (HP:0001520)3.23523531
28Late onset (HP:0003584)3.20814430
29Deep venous thrombosis (HP:0002625)3.17186166
30Tetany (HP:0001281)3.13875149
31Glycosuria (HP:0003076)3.09811690
32Abnormality of urine glucose concentration (HP:0011016)3.09811690
33Hepatic necrosis (HP:0002605)3.07203632
34Xanthomatosis (HP:0000991)3.02907510
35Proximal tubulopathy (HP:0000114)3.02090831
36Decreased circulating renin level (HP:0003351)3.00920789
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.00749760
38Ketosis (HP:0001946)2.98387550
39Dicarboxylic aciduria (HP:0003215)2.97883270
40Abnormality of dicarboxylic acid metabolism (HP:0010995)2.97883270
41Abnormality of aspartate family amino acid metabolism (HP:0010899)2.95632303
42Increased cerebral lipofuscin (HP:0011813)2.91341118
43Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.90273144
44Hypoglycemic coma (HP:0001325)2.87786492
45Clumsiness (HP:0002312)2.84192984
46Delayed CNS myelination (HP:0002188)2.84071750
47Abnormality of magnesium homeostasis (HP:0004921)2.79377308
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.78931743
49Hyperventilation (HP:0002883)2.78825024
50Abnormality of nucleobase metabolism (HP:0010932)2.75938353
51Pigmentary retinal degeneration (HP:0001146)2.67551625
52Hypochromic anemia (HP:0001931)2.66225787
53Hepatocellular necrosis (HP:0001404)2.64091145
54Hyperbilirubinemia (HP:0002904)2.63211473
55Progressive cerebellar ataxia (HP:0002073)2.61209108
56Lipid accumulation in hepatocytes (HP:0006561)2.60759262
57Increased muscle lipid content (HP:0009058)2.60047247
58Lethargy (HP:0001254)2.58836928
59Hypothermia (HP:0002045)2.56767554
60Abnormality of the common coagulation pathway (HP:0010990)2.56083732
61Abnormality of serum amino acid levels (HP:0003112)2.55681675
62Autoimmune thrombocytopenia (HP:0001973)2.55073195
63Systemic lupus erythematosus (HP:0002725)2.54026240
64Hypobetalipoproteinemia (HP:0003563)2.53830269
65Increased intramyocellular lipid droplets (HP:0012240)2.52748175
66Hemorrhage of the eye (HP:0011885)2.50218472
67Abnormal delayed hypersensitivity skin test (HP:0002963)2.49933397
68Abnormal urine output (HP:0012590)2.48391171
69Abnormality of sulfur amino acid metabolism (HP:0004339)2.46988577
70Ketoacidosis (HP:0001993)2.44513828
71Renal Fanconi syndrome (HP:0001994)2.44341934
72Hyperphosphaturia (HP:0003109)2.41318311
73Congenital sensorineural hearing impairment (HP:0008527)2.40259710
74Alkalosis (HP:0001948)2.39784277
75Polyuria (HP:0000103)2.35120756
76Increased hepatocellular lipid droplets (HP:0006565)2.34729542
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.33641471
78Abnormality of methionine metabolism (HP:0010901)2.33039640
79Vacuolated lymphocytes (HP:0001922)2.30217964
80Metabolic acidosis (HP:0001942)2.29869269
81Hyperlipoproteinemia (HP:0010980)2.29866786
82Cerebral palsy (HP:0100021)2.29509285
83Abnormality of purine metabolism (HP:0004352)2.29188088
84Thyroid-stimulating hormone excess (HP:0002925)2.28440789
85Fat malabsorption (HP:0002630)2.26954249
86Stomach cancer (HP:0012126)2.26469378
87Abnormality of the intrinsic pathway (HP:0010989)2.25968080
88Nausea (HP:0002018)2.25152358
89Facial shape deformation (HP:0011334)2.22205250
90Potter facies (HP:0002009)2.22205250
91Dysmetric saccades (HP:0000641)2.21324244
92Gaze-evoked nystagmus (HP:0000640)2.21236851
93Gout (HP:0001997)2.19210987
94Renal tubular dysfunction (HP:0000124)2.19160717
95Opisthotonus (HP:0002179)2.15322292
96Chronic diarrhea (HP:0002028)2.15164113
97Cerebral edema (HP:0002181)2.14412152
98Abnormality of binocular vision (HP:0011514)2.13936265
99Diplopia (HP:0000651)2.13936265
100Hypomagnesemia (HP:0002917)2.11763446
101Pancreatitis (HP:0001733)2.10151564
102Abnormal urine phosphate concentration (HP:0012599)2.09224950
103Abnormality of liposaccharide metabolism (HP:0010968)2.09045268
104Abnormality of glycosphingolipid metabolism (HP:0004343)2.09045268
105Abnormality of glycolipid metabolism (HP:0010969)2.09045268
106Abnormality of renal excretion (HP:0011036)2.08755643
107Recurrent gram-negative bacterial infections (HP:0005420)2.08246354
108Abnormality of renal resorption (HP:0011038)2.07303682
109Fair hair (HP:0002286)2.06769423
110Microcytic anemia (HP:0001935)2.06436688
111Vomiting (HP:0002013)2.06137857
112Decreased activity of mitochondrial respiratory chain (HP:0008972)2.05353460
113Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.05353460
114Hyperactive renin-angiotensin system (HP:0000841)2.04929799
115Nephritis (HP:0000123)2.04803341
116Spontaneous abortion (HP:0005268)2.01644053
117Renal tubular acidosis (HP:0001947)2.01409724
118Abnormality of mucopolysaccharide metabolism (HP:0011020)2.01300765
119Abnormality of polysaccharide metabolism (HP:0011012)2.01300765
120Abnormality of glycosaminoglycan metabolism (HP:0004371)2.01300765
121Complement deficiency (HP:0004431)2.00094519
122Protruding tongue (HP:0010808)2.00081954
123Reticulocytopenia (HP:0001896)1.99934700
124Mesangial abnormality (HP:0001966)1.99632262
125Vascular calcification (HP:0004934)1.98424320
126Hydroxyprolinuria (HP:0003080)1.97404517
127Abnormality of proline metabolism (HP:0010907)1.97404517
128Glomerulonephritis (HP:0000099)1.97219608
129Renal cortical cysts (HP:0000803)1.96943770
130Elevated hepatic transaminases (HP:0002910)1.95967226
131Arthropathy (HP:0003040)1.95678930
132Mucopolysacchariduria (HP:0008155)1.94947429
133Urinary glycosaminoglycan excretion (HP:0003541)1.94947429
134Abnormal number of erythroid precursors (HP:0012131)1.94333966
135Hypoplastic ischia (HP:0003175)1.93928118
136Abnormality of renin-angiotensin system (HP:0000847)1.92831959
137Exertional dyspnea (HP:0002875)1.92627394
138Hypolipoproteinemia (HP:0010981)1.92196060
139Abnormality of the renal cortex (HP:0011035)1.91363524
140Thrombocytosis (HP:0001894)1.90805912
141Conjugated hyperbilirubinemia (HP:0002908)1.89888976
142Increased purine levels (HP:0004368)1.88973191
143Hyperuricemia (HP:0002149)1.88973191
144Abnormality of transition element cation homeostasis (HP:0011030)1.87950844
145Metabolic alkalosis (HP:0200114)1.87188234
146Dysostosis multiplex (HP:0000943)1.85735335
147Decreased central vision (HP:0007663)1.84438591
148Abnormality of the axillary hair (HP:0100134)1.83190532
149Abnormality of secondary sexual hair (HP:0009888)1.83190532
150Epidermoid cyst (HP:0200040)1.83009088
151Hypercholesterolemia (HP:0003124)1.82436427
152Hypercalciuria (HP:0002150)1.81576078
153Malnutrition (HP:0004395)1.81205214
154Generalized hypopigmentation of hair (HP:0011358)1.81071494
155Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80727684
156Cardiovascular calcification (HP:0011915)1.80710728
157Abnormality of complement system (HP:0005339)1.79689411
158Gingival bleeding (HP:0000225)1.78835014
159Steatorrhea (HP:0002570)1.76686735
160Enlarged kidneys (HP:0000105)1.75825953
161Enlarged epiphyses (HP:0010580)1.75824909
162Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.75463763
163Abolished electroretinogram (ERG) (HP:0000550)1.75315928
164Petechiae (HP:0000967)1.75310924
165Ileus (HP:0002595)1.75019517
166Attenuation of retinal blood vessels (HP:0007843)1.73776558
167Hemiplegia (HP:0002301)1.73394348
168Chorioretinal atrophy (HP:0000533)1.73250788
169Macroglossia (HP:0000158)1.73042315
170Abnormality of the wing of the ilium (HP:0011867)1.72751891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.90348956
2EIF2AK34.86742597
3FRK4.71916028
4BCKDK3.97198903
5TRIB33.32085705
6MUSK3.25454937
7ACVR1B3.02360250
8IRAK32.86723218
9NME22.64940349
10NLK2.45541187
11MKNK22.44590014
12STK162.23721682
13IRAK42.17900008
14PIM22.02257154
15BMPR1B2.01143034
16FLT31.98895818
17ERN11.93292353
18CAMKK21.83011345
19EIF2AK21.80900904
20MAPKAPK31.70933481
21EEF2K1.65912941
22MKNK11.65697479
23SIK21.57000101
24TLK11.46177058
25PIK3CA1.46155250
26SRPK11.37032928
27GRK11.34430027
28OBSCN1.33766486
29KIT1.33542577
30FGFR41.32566542
31YES11.32486510
32TGFBR21.30725275
33TBK11.26552176
34TEC1.24657934
35EPHA31.23207623
36CAMK1D1.23129940
37TYK21.22182869
38AKT31.20097044
39NEK91.19778927
40FGFR31.19410400
41MAP3K141.18394100
42TAOK21.17935069
43TIE11.13697896
44BTK1.13241713
45DAPK21.12685033
46IKBKB1.11587478
47PRPF4B1.09171201
48TRPM71.06481805
49IKBKE1.03735389
50MST1R1.03380100
51PTK61.02475989
52KDR1.02473217
53MAP2K31.01098045
54MATK0.99511369
55TNK20.97863519
56ZAK0.96576575
57ABL20.95087850
58PDPK10.91852549
59IRAK10.90994555
60CDK80.90723854
61PRKAA10.90477958
62PINK10.88181049
63PDK10.87302686
64RET0.84370680
65MYLK0.84240350
66PIM10.83906530
67MAPK120.83229604
68BUB10.81916951
69PIK3CG0.81217507
70ICK0.80763548
71CDK120.80646790
72CASK0.80073960
73WNK30.78403788
74STK390.77336426
75CSF1R0.75717178
76IRAK20.74818685
77PHKG10.74311118
78PHKG20.74311118
79SGK20.73116534
80NTRK30.73104843
81TAOK30.72180936
82RIPK40.72150843
83VRK10.72019418
84MAPK110.72002533
85WNK40.71130307
86OXSR10.70357542
87NUAK10.70312350
88FES0.69992076
89INSRR0.68417358
90LYN0.67986580
91CHUK0.67043461
92ITK0.66965060
93MAP2K10.66340768
94MST40.66014077
95CAMK1G0.65788044
96JAK10.65664848
97MAP4K10.65605128
98FGFR20.64384954
99ZAP700.63855388
100DYRK1B0.63515892
101MARK20.63473721
102PRKG20.63040617
103ERBB20.62711878
104SIK10.62390816
105PRKCQ0.61727373
106CLK10.60950498
107CAMKK10.60940490
108ADRBK10.60690922
109PTK2B0.59481042
110CDC42BPA0.58279590
111HCK0.55864203
112PRKCI0.55585425
113BLK0.55552513
114MAPK40.55311408
115PKN10.54139090
116TYRO30.52665170
117PRKCZ0.52052506
118MAP3K70.51398702
119EPHB10.50309867
120DYRK30.50076853
121LCK0.49960068
122PRKCH0.49933536
123MAP2K60.49718815
124TXK0.49636967
125PKN20.49043167
126SYK0.48778137
127ADRBK20.48697527
128SGK30.48371373
129GRK60.47898165
130CDK70.47847693
131MTOR0.47410382
132PRKD20.46942431
133HIPK20.46618542
134WNK10.46262588
135TGFBR10.46171146
136MAP2K20.42868405
137WEE10.41986737
138CSK0.40146280
139PRKAA20.40127872
140EIF2AK10.39680768
141MAPK150.38422754
142PAK40.36596234
143PRKCD0.36285381
144RPS6KA60.36232351
145RPS6KC10.35884636
146RPS6KL10.35884636
147CAMK10.34962101
148LRRK20.34565276
149STK38L0.33970487
150CDK40.33570374
151ERBB30.33479240
152EPHB20.32380061
153EPHA20.31761866
154CAMK40.30710042
155FER0.29695811

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.36656614
2Pentose and glucuronate interconversions_Homo sapiens_hsa000403.10931186
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.99690556
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37672255
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.29638797
6Fatty acid degradation_Homo sapiens_hsa000712.28821119
7Tryptophan metabolism_Homo sapiens_hsa003802.22727310
8Peroxisome_Homo sapiens_hsa041462.22220852
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.20774907
10Steroid hormone biosynthesis_Homo sapiens_hsa001402.14797929
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.14510768
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.10520195
13Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.09241664
14Arginine biosynthesis_Homo sapiens_hsa002201.92853917
15Drug metabolism - other enzymes_Homo sapiens_hsa009831.90648110
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.89695015
17Propanoate metabolism_Homo sapiens_hsa006401.81318969
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77442190
19Folate biosynthesis_Homo sapiens_hsa007901.74421518
20Chemical carcinogenesis_Homo sapiens_hsa052041.70921902
21Complement and coagulation cascades_Homo sapiens_hsa046101.68840330
22Sulfur metabolism_Homo sapiens_hsa009201.65073160
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.64885602
24Starch and sucrose metabolism_Homo sapiens_hsa005001.64870665
25Selenocompound metabolism_Homo sapiens_hsa004501.63976606
26beta-Alanine metabolism_Homo sapiens_hsa004101.62012387
27Histidine metabolism_Homo sapiens_hsa003401.59320354
28Butanoate metabolism_Homo sapiens_hsa006501.57317972
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.51195934
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.48576614
31Retinol metabolism_Homo sapiens_hsa008301.47749734
32Ribosome_Homo sapiens_hsa030101.47585451
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45111867
34Fatty acid metabolism_Homo sapiens_hsa012121.43173399
35One carbon pool by folate_Homo sapiens_hsa006701.43151288
36PPAR signaling pathway_Homo sapiens_hsa033201.41601879
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40389615
38Other glycan degradation_Homo sapiens_hsa005111.39826281
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38451434
40Vitamin digestion and absorption_Homo sapiens_hsa049771.36353049
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35988860
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29488987
43Sulfur relay system_Homo sapiens_hsa041221.27773530
44Fatty acid elongation_Homo sapiens_hsa000621.27453625
45DNA replication_Homo sapiens_hsa030301.26152021
46Caffeine metabolism_Homo sapiens_hsa002321.24741664
47Glutathione metabolism_Homo sapiens_hsa004801.22686416
48Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17164531
49Carbon metabolism_Homo sapiens_hsa012001.11908638
50Nitrogen metabolism_Homo sapiens_hsa009101.11125999
51Ether lipid metabolism_Homo sapiens_hsa005651.11075071
52Arginine and proline metabolism_Homo sapiens_hsa003301.10691359
53Insulin resistance_Homo sapiens_hsa049311.10409422
54Staphylococcus aureus infection_Homo sapiens_hsa051501.06663271
55Pentose phosphate pathway_Homo sapiens_hsa000301.06432810
56Biosynthesis of amino acids_Homo sapiens_hsa012301.05979325
57Phenylalanine metabolism_Homo sapiens_hsa003601.03654288
58Protein export_Homo sapiens_hsa030601.01817183
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.97567022
60Pyruvate metabolism_Homo sapiens_hsa006200.96965638
61Fat digestion and absorption_Homo sapiens_hsa049750.92644699
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90674736
63ABC transporters_Homo sapiens_hsa020100.90620709
64Pyrimidine metabolism_Homo sapiens_hsa002400.90041172
65Tyrosine metabolism_Homo sapiens_hsa003500.86817957
66Mineral absorption_Homo sapiens_hsa049780.82375131
67N-Glycan biosynthesis_Homo sapiens_hsa005100.81458282
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81215571
69Base excision repair_Homo sapiens_hsa034100.79936015
70Galactose metabolism_Homo sapiens_hsa000520.78707991
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78550284
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.75893376
73Metabolic pathways_Homo sapiens_hsa011000.75028149
74Salivary secretion_Homo sapiens_hsa049700.73426675
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72801232
76Bile secretion_Homo sapiens_hsa049760.70862338
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70550607
78Ovarian steroidogenesis_Homo sapiens_hsa049130.68628249
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.68544056
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67279167
81Protein digestion and absorption_Homo sapiens_hsa049740.66287955
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.65709329
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64307519
84Insulin secretion_Homo sapiens_hsa049110.64219379
85Lysosome_Homo sapiens_hsa041420.63698299
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62085104
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60926240
88Fatty acid biosynthesis_Homo sapiens_hsa000610.60785145
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59979749
90Phototransduction_Homo sapiens_hsa047440.59567486
91Arachidonic acid metabolism_Homo sapiens_hsa005900.59278098
92Lysine degradation_Homo sapiens_hsa003100.59217224
93Graft-versus-host disease_Homo sapiens_hsa053320.58796750
94Mismatch repair_Homo sapiens_hsa034300.58682914
95Serotonergic synapse_Homo sapiens_hsa047260.58556941
96Fructose and mannose metabolism_Homo sapiens_hsa000510.55730644
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55102359
98Type II diabetes mellitus_Homo sapiens_hsa049300.54992577
99Homologous recombination_Homo sapiens_hsa034400.54436434
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.54049279
101Morphine addiction_Homo sapiens_hsa050320.52875295
102Platelet activation_Homo sapiens_hsa046110.52050522
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51634829
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51144071
105Dorso-ventral axis formation_Homo sapiens_hsa043200.51069250
106Thyroid hormone synthesis_Homo sapiens_hsa049180.50831233
107Glycerolipid metabolism_Homo sapiens_hsa005610.50475581
108Calcium signaling pathway_Homo sapiens_hsa040200.49057053
109Allograft rejection_Homo sapiens_hsa053300.48756198
110Autoimmune thyroid disease_Homo sapiens_hsa053200.48222691
111B cell receptor signaling pathway_Homo sapiens_hsa046620.47260363
112Asthma_Homo sapiens_hsa053100.45460282
113Renin-angiotensin system_Homo sapiens_hsa046140.45217823
114African trypanosomiasis_Homo sapiens_hsa051430.44817233
115Proteasome_Homo sapiens_hsa030500.40756181
116Pancreatic secretion_Homo sapiens_hsa049720.39864416
117Oxidative phosphorylation_Homo sapiens_hsa001900.39621255
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39393053
119Steroid biosynthesis_Homo sapiens_hsa001000.39081860
120Cholinergic synapse_Homo sapiens_hsa047250.38823795
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37903150
122Circadian entrainment_Homo sapiens_hsa047130.37404079
123Type I diabetes mellitus_Homo sapiens_hsa049400.37067925
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36843971
125Thyroid cancer_Homo sapiens_hsa052160.35399422
126RNA polymerase_Homo sapiens_hsa030200.33011823
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31660355
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31655109
129FoxO signaling pathway_Homo sapiens_hsa040680.31028657
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30934703
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29974301
132Sphingolipid metabolism_Homo sapiens_hsa006000.29647695
133Glutamatergic synapse_Homo sapiens_hsa047240.28849723
134Purine metabolism_Homo sapiens_hsa002300.26372594
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24529244
136Non-homologous end-joining_Homo sapiens_hsa034500.23255428
137NF-kappa B signaling pathway_Homo sapiens_hsa040640.23215752
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.20631129
139Parkinsons disease_Homo sapiens_hsa050120.20312207
140Nucleotide excision repair_Homo sapiens_hsa034200.18604245
141Leishmaniasis_Homo sapiens_hsa051400.15129291
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14813862
143Linoleic acid metabolism_Homo sapiens_hsa005910.14423515

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