PGPEP1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-mediated cell contraction (GO:0070252)9.85640689
2regulation of skeletal muscle contraction (GO:0014819)9.18053104
3positive regulation of gamma-delta T cell activation (GO:0046645)7.52564612
4actin filament-based movement (GO:0030048)7.15639396
5negative T cell selection (GO:0043383)7.11425335
6response to stimulus involved in regulation of muscle adaptation (GO:0014874)7.07436265
7regulation of gamma-delta T cell differentiation (GO:0045586)6.96399826
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.74745586
9myofibril assembly (GO:0030239)6.74543684
10response to muscle activity (GO:0014850)6.72745932
11striated muscle contraction (GO:0006941)6.60858357
12sarcomere organization (GO:0045214)6.60384222
13regulation of gamma-delta T cell activation (GO:0046643)6.44133312
14negative thymic T cell selection (GO:0045060)6.40992033
15creatine metabolic process (GO:0006600)6.39175447
16positive T cell selection (GO:0043368)6.27006793
17positive thymic T cell selection (GO:0045059)5.98670458
18regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.96398371
19response to inactivity (GO:0014854)5.94238029
20skeletal muscle fiber development (GO:0048741)5.78373078
21skeletal muscle adaptation (GO:0043501)5.76131945
22positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.66233636
23thymic T cell selection (GO:0045061)5.60499449
24myotube cell development (GO:0014904)5.57820238
25T cell selection (GO:0045058)5.56829068
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.56415634
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.56415634
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.34588950
29muscle contraction (GO:0006936)5.25646999
30response to interleukin-15 (GO:0070672)5.19234263
31antigen processing and presentation of endogenous antigen (GO:0019883)5.18039775
32T cell receptor signaling pathway (GO:0050852)5.02212870
33muscle fiber development (GO:0048747)4.98621740
34cardiac myofibril assembly (GO:0055003)4.97841484
35regulation of T cell tolerance induction (GO:0002664)4.89101326
36actomyosin structure organization (GO:0031032)4.87014064
37glycogen catabolic process (GO:0005980)4.81192267
38negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.74335276
39negative regulation of cell killing (GO:0031342)4.73332009
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.73332009
41cardiac muscle contraction (GO:0060048)4.70964968
42muscle system process (GO:0003012)4.68898687
43regulation of actin filament-based movement (GO:1903115)4.67805369
44response to hydroperoxide (GO:0033194)4.60281069
45regulation of isotype switching to IgG isotypes (GO:0048302)4.56744805
46positive regulation of interleukin-2 production (GO:0032743)4.56150445
47glucan catabolic process (GO:0009251)4.48319740
48plasma membrane repair (GO:0001778)4.47621954
49regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.45510347
50T cell costimulation (GO:0031295)4.41377655
51regulation of cell communication by electrical coupling (GO:0010649)4.37286909
52cardiac muscle hypertrophy (GO:0003300)4.36345264
53striated muscle adaptation (GO:0014888)4.34519839
54muscle cell cellular homeostasis (GO:0046716)4.33571932
55lymphocyte costimulation (GO:0031294)4.32317428
56NIK/NF-kappaB signaling (GO:0038061)4.31762669
57cellular polysaccharide catabolic process (GO:0044247)4.30449535
58regulation of regulatory T cell differentiation (GO:0045589)4.29460543
59skeletal muscle tissue regeneration (GO:0043403)4.28436504
60glycogen biosynthetic process (GO:0005978)4.24324259
61glucan biosynthetic process (GO:0009250)4.24324259
62signal complex assembly (GO:0007172)4.24155273
63cellular response to interleukin-15 (GO:0071350)4.20180168
64striated muscle hypertrophy (GO:0014897)4.16524182
65striated muscle atrophy (GO:0014891)4.15752318
66skeletal muscle tissue development (GO:0007519)4.13562436
67negative regulation of potassium ion transmembrane transport (GO:1901380)4.07706172
68antigen receptor-mediated signaling pathway (GO:0050851)4.05333518
69polysaccharide catabolic process (GO:0000272)4.03851512
70regulation of alpha-beta T cell proliferation (GO:0046640)4.01017976
71heart contraction (GO:0060047)3.91760356
72heart process (GO:0003015)3.91760356
73muscle atrophy (GO:0014889)3.88122763
74positive regulation of tolerance induction (GO:0002645)3.87728429
75striated muscle cell development (GO:0055002)3.86738008
76regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.81571272
77regulation of striated muscle contraction (GO:0006942)3.79808046
78response to activity (GO:0014823)3.77022372
79fructose metabolic process (GO:0006000)3.76069145
80positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.75205868
81T cell migration (GO:0072678)3.74859908
82regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.73983158
83leukocyte aggregation (GO:0070486)3.69885442
84positive regulation of humoral immune response (GO:0002922)3.68477593
85adult heart development (GO:0007512)3.67827477
86regulation of interleukin-12 biosynthetic process (GO:0045075)3.65465606
87neuromuscular synaptic transmission (GO:0007274)3.63218837
88regulation of interleukin-2 biosynthetic process (GO:0045076)3.62869137
89muscle hypertrophy (GO:0014896)3.62380911
90muscle tissue morphogenesis (GO:0060415)3.61442848
91oxygen transport (GO:0015671)3.56226693
92neuronal action potential propagation (GO:0019227)3.53957836
93regulation of T cell receptor signaling pathway (GO:0050856)3.53586913
94muscle structure development (GO:0061061)3.53270060
95regulation of B cell receptor signaling pathway (GO:0050855)3.51084432
96muscle organ development (GO:0007517)3.48081327
97cardiac muscle tissue morphogenesis (GO:0055008)3.44465934
98muscle adaptation (GO:0043500)3.43361658
99positive regulation of alpha-beta T cell proliferation (GO:0046641)3.42173308
100glycogen metabolic process (GO:0005977)3.41824443
101tyrosine phosphorylation of STAT protein (GO:0007260)3.40001642
102detection of light stimulus involved in visual perception (GO:0050908)3.39711237
103detection of light stimulus involved in sensory perception (GO:0050962)3.39711237
104myotube differentiation (GO:0014902)3.39446214
105JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.38267124
106V(D)J recombination (GO:0033151)3.37700087
107DNA damage induced protein phosphorylation (GO:0006975)3.36044667
108muscle organ morphogenesis (GO:0048644)3.36012472
109ubiquinone biosynthetic process (GO:0006744)3.35033351
110regulation of tolerance induction (GO:0002643)3.33872346
111cellular glucan metabolic process (GO:0006073)3.33737607
112glucan metabolic process (GO:0044042)3.33737607
113positive regulation of cation channel activity (GO:2001259)3.33728606
114regulation of response to interferon-gamma (GO:0060330)3.33502901
115regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.33400869
116regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.30129472
117muscle cell fate commitment (GO:0042693)3.29891305
118gluconeogenesis (GO:0006094)3.28493429
119muscle cell development (GO:0055001)3.28151861
120cellular response to interleukin-4 (GO:0071353)3.27849292
121regulation of calcium ion transmembrane transporter activity (GO:1901019)3.26931657
122regulation of calcium ion transmembrane transport (GO:1903169)3.26931657
123positive regulation of myoblast differentiation (GO:0045663)3.26742587
124regulation of myoblast differentiation (GO:0045661)3.26016099
125response to interleukin-4 (GO:0070670)3.22888121
126cardiac muscle cell development (GO:0055013)3.18410760
127cardiac muscle adaptation (GO:0014887)3.17595574
128cardiac muscle hypertrophy in response to stress (GO:0014898)3.17595574
129muscle hypertrophy in response to stress (GO:0003299)3.17595574
130NADH metabolic process (GO:0006734)3.17326866
131otic vesicle formation (GO:0030916)3.15505534
132negative regulation of protein localization to cell surface (GO:2000009)3.14393371
133regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.13980507
134positive regulation of histone deacetylation (GO:0031065)3.12737665
135interferon-gamma production (GO:0032609)3.12489060
136negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.10343324
137negative regulation of calcium ion transmembrane transport (GO:1903170)3.10343324
138regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.07165711
139oxidative phosphorylation (GO:0006119)3.06781073
140piRNA metabolic process (GO:0034587)3.05523929
141negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.04984676
142mucosal-associated lymphoid tissue development (GO:0048537)3.03259954
143Peyers patch development (GO:0048541)3.03259954
144cellular carbohydrate catabolic process (GO:0044275)3.02103678
145regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.01913768
146response to pheromone (GO:0019236)3.01661090
147hexose biosynthetic process (GO:0019319)3.00541826
148cardiac cell development (GO:0055006)3.00423820
149IMP metabolic process (GO:0046040)3.00346751
150regulation of interleukin-2 production (GO:0032663)2.98180371
151positive regulation of granulocyte differentiation (GO:0030854)2.98092977
152gamma-aminobutyric acid transport (GO:0015812)2.96647064
153protein ADP-ribosylation (GO:0006471)2.96630120
154regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.96125752
155ubiquinone metabolic process (GO:0006743)2.95153464
156immune response-activating cell surface receptor signaling pathway (GO:0002429)2.93779879
157activated T cell proliferation (GO:0050798)2.92583713
158cellular response to zinc ion (GO:0071294)2.83141246
1592-oxoglutarate metabolic process (GO:0006103)2.82850989
160oxaloacetate metabolic process (GO:0006107)2.82190204
161regulation of extracellular matrix disassembly (GO:0010715)2.78794688
162valine metabolic process (GO:0006573)2.78241546
163cellular hyperosmotic response (GO:0071474)2.78213336
164myeloid dendritic cell differentiation (GO:0043011)2.72222486
165mature B cell differentiation (GO:0002335)2.69982656
166dicarboxylic acid biosynthetic process (GO:0043650)2.69658418
167surfactant homeostasis (GO:0043129)2.69133804
168T cell homeostasis (GO:0043029)2.68828036
169positive regulation of T cell activation (GO:0050870)2.68114919
170negative regulation of bone resorption (GO:0045779)2.65577647
171alpha-beta T cell differentiation (GO:0046632)2.64292282
172tumor necrosis factor-mediated signaling pathway (GO:0033209)2.63212191
173sarcoplasmic reticulum calcium ion transport (GO:0070296)2.63082304
174B cell receptor signaling pathway (GO:0050853)2.61836252
175growth hormone receptor signaling pathway (GO:0060396)2.60734639
176T cell differentiation (GO:0030217)2.57759444
177negative regulation of thymocyte apoptotic process (GO:0070244)2.56851474
178alpha-beta T cell activation (GO:0046631)2.56542171
179negative regulation of T cell receptor signaling pathway (GO:0050860)2.53725090
180regulation of relaxation of muscle (GO:1901077)2.53017467
181protein autoprocessing (GO:0016540)2.50487926
182positive regulation of isotype switching (GO:0045830)2.48164586
183myeloid dendritic cell activation (GO:0001773)2.46645416
184positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.46640501
185positive regulation of natural killer cell mediated immunity (GO:0002717)2.46640501
186positive regulation of T cell differentiation (GO:0045582)2.46441701
187skeletal muscle contraction (GO:0003009)2.44188472
188focal adhesion assembly (GO:0048041)2.42993873
189cell-substrate adherens junction assembly (GO:0007045)2.42993873
190necroptotic process (GO:0070266)2.42405630
191pericardium development (GO:0060039)2.42359288
192T cell activation (GO:0042110)2.41511719
193regulation of T cell differentiation (GO:0045580)2.39365249
194regulation of B cell differentiation (GO:0045577)2.38938776
195actin-myosin filament sliding (GO:0033275)11.8948579
196muscle filament sliding (GO:0030049)11.8948579

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.70107448
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.52938966
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.42126145
4* MYC_22102868_ChIP-Seq_BL_Human4.53669975
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.39352066
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.01648147
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.50071987
8FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.37255029
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.33061434
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.28384584
11* IGF1R_20145208_ChIP-Seq_DFB_Human3.08298043
12RUNX_20019798_ChIP-Seq_JUKART_Human2.98292136
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.96014055
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.84989805
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.76106918
16VDR_22108803_ChIP-Seq_LS180_Human2.74410705
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.73202369
18* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.67534573
19VDR_21846776_ChIP-Seq_THP-1_Human2.59056851
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.56866779
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53037943
22TCF7_22412390_ChIP-Seq_EML_Mouse2.52822439
23MAF_26560356_Chip-Seq_TH1_Human2.52201005
24* KDM2B_26808549_Chip-Seq_DND41_Human2.48743469
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.44857467
26IRF8_22096565_ChIP-ChIP_GC-B_Human2.44718380
27MYB_26560356_Chip-Seq_TH2_Human2.43370873
28UTX_26944678_Chip-Seq_JUKART_Human2.41890167
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.34846435
30SMAD_19615063_ChIP-ChIP_OVARY_Human2.30882105
31KDM2B_26808549_Chip-Seq_SUP-B15_Human2.27849344
32FLI1_27457419_Chip-Seq_LIVER_Mouse2.26266768
33ZNF274_21170338_ChIP-Seq_K562_Hela2.22722785
34NOTCH1_21737748_ChIP-Seq_TLL_Human2.20158606
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19673612
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.18192428
37PCGF2_27294783_Chip-Seq_ESCs_Mouse2.08762600
38ESR1_20079471_ChIP-ChIP_T-47D_Human2.07320073
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.06945302
40MYB_26560356_Chip-Seq_TH1_Human2.04948873
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.01909660
42GBX2_23144817_ChIP-Seq_PC3_Human1.99334274
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.98914063
44PPARA_22158963_ChIP-Seq_LIVER_Mouse1.94982661
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.90229589
46LXR_22158963_ChIP-Seq_LIVER_Mouse1.87740537
47MAF_26560356_Chip-Seq_TH2_Human1.87213101
48FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.82252879
49* KDM2B_26808549_Chip-Seq_JURKAT_Human1.81298157
50CLOCK_20551151_ChIP-Seq_293T_Human1.79614334
51RXR_22158963_ChIP-Seq_LIVER_Mouse1.75124636
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.72501598
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67970771
54BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.66531893
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.65853045
56E2F7_22180533_ChIP-Seq_HELA_Human1.64892754
57ER_23166858_ChIP-Seq_MCF-7_Human1.64874391
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64495930
59CBP_20019798_ChIP-Seq_JUKART_Human1.64495930
60MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.64009700
61MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63506897
62VDR_24763502_ChIP-Seq_THP-1_Human1.61188635
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.59137456
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57217253
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.56749802
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56321643
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55369824
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55159397
69OCT4_20526341_ChIP-Seq_ESCs_Human1.53790760
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53270700
71EP300_21415370_ChIP-Seq_HL-1_Mouse1.51864694
72GATA3_27048872_Chip-Seq_THYMUS_Human1.50562465
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50448894
74* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.49493433
75* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.38986142
76HTT_18923047_ChIP-ChIP_STHdh_Human1.36153356
77CIITA_25753668_ChIP-Seq_RAJI_Human1.30206705
78AR_21572438_ChIP-Seq_LNCaP_Human1.28784870
79FUS_26573619_Chip-Seq_HEK293_Human1.28750093
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28616466
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28517564
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.28205653
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.26483794
84BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26434943
85* SOX2_19829295_ChIP-Seq_ESCs_Human1.24457370
86* NANOG_19829295_ChIP-Seq_ESCs_Human1.24457370
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24417182
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23889314
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22339870
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.22079848
91LXR_22292898_ChIP-Seq_THP-1_Human1.18766690
92AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17872683
93NANOG_20526341_ChIP-Seq_ESCs_Human1.16547684
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.15913287
95SRF_21415370_ChIP-Seq_HL-1_Mouse1.13509784
96SPI1_23127762_ChIP-Seq_K562_Human1.13331981
97KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13008950
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12931735
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11876892
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11851719
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11437878
102ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11246536
103* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11050035
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11021648
105SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10932854
106ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10582065
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10072111
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09506187
109RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09476330
110TCF4_23295773_ChIP-Seq_U87_Human1.08641070
111SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08607674
112GATA4_21415370_ChIP-Seq_HL-1_Mouse1.08606936
113TP53_22573176_ChIP-Seq_HFKS_Human1.07497292
114HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07418848
115P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07130958
116NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06160916
117SMAD4_21799915_ChIP-Seq_A2780_Human1.06093703
118IRF8_27001747_Chip-Seq_BMDM_Mouse1.03751806
119SOX2_21211035_ChIP-Seq_LN229_Gbm1.03649237
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02690009
121FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02212893
122ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01137314
123WDR5_24793694_ChIP-Seq_LNCAP_Human1.00953542
124NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00744180
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00607347
126SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00349157
127CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99104851
128RACK7_27058665_Chip-Seq_MCF-7_Human0.98699373
129ZNF263_19887448_ChIP-Seq_K562_Human0.98698233
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97082891
131OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96495135
132CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95897515
133VDR_24787735_ChIP-Seq_THP-1_Human0.94919025
134EGR1_19032775_ChIP-ChIP_M12_Human0.94424226
135PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94348859
136TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94336531
137P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94170053
138PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93931126
139CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93768969
140RNF2_27304074_Chip-Seq_NSC_Mouse0.93487833
141SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93175033
142SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92795455
143EZH2_27294783_Chip-Seq_ESCs_Mouse0.92520469
144CREB1_26743006_Chip-Seq_LNCaP_Human0.92307596
145HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92150839
146NCOR1_26117541_ChIP-Seq_K562_Human0.91131122
147GATA2_19941826_ChIP-Seq_K562_Human0.90444400
148RAC3_21632823_ChIP-Seq_H3396_Human0.89989800
149TBX20_22080862_ChIP-Seq_HEART_Mouse0.88866889
150TBX20_22328084_ChIP-Seq_HEART_Mouse0.88866889
151DROSHA_22980978_ChIP-Seq_HELA_Human0.88552913
152EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88427341
153* MYC_19829295_ChIP-Seq_ESCs_Human0.88330561
154STAT3_23295773_ChIP-Seq_U87_Human0.88277596
155LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88064115
156SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87843692
157* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87663112
158P53_21459846_ChIP-Seq_SAOS-2_Human0.87547510
159FLI1_21867929_ChIP-Seq_TH2_Mouse0.86384085
160* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86301682
161TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86231642
162GATA1_19941826_ChIP-Seq_K562_Human0.85653068
163CTCF_21964334_ChIP-Seq_BJAB-B_Human0.85191211
164* NCOR_22424771_ChIP-Seq_293T_Human0.84611212
165SOX2_22085726_ChIP-Seq_NPCs_Mouse0.84430579
166KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84181583
167ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84061052
168SMAD4_21741376_ChIP-Seq_EPCs_Human0.83584866
169HOXB7_26014856_ChIP-Seq_BT474_Human0.82825992
170ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.82343919
171TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.82241728
172FOXO3_23340844_ChIP-Seq_DLD1_Human0.81481229
173CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81312298
174* FOXH1_21741376_ChIP-Seq_EPCs_Human0.81257197
175GATA3_26560356_Chip-Seq_TH2_Human0.80764654
176PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80366020
177HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.80138384
178KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79959952
179TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79215970
180POU5F1_16518401_ChIP-PET_MESCs_Mouse0.79098116
181SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78953546
182OCT4_19829295_ChIP-Seq_ESCs_Human0.78743944
183GATA2_21666600_ChIP-Seq_HMVEC_Human0.78613252
184P300_19829295_ChIP-Seq_ESCs_Human0.77813629
185STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.76681437
186SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75506783
187TAF15_26573619_Chip-Seq_HEK293_Human0.74721808
188JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.72925184
189CTCF_27219007_Chip-Seq_Bcells_Human0.72847151
190PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.72666949
191THAP11_20581084_ChIP-Seq_MESCs_Mouse0.72347967
192MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.71793390
193NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.70787299
194SPI1_20517297_ChIP-Seq_HL60_Human0.70408611

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio6.54597172
2MP0003763_abnormal_thymus_physiology4.88293077
3MP0000685_abnormal_immune_system4.72640578
4MP0004084_abnormal_cardiac_muscle3.73787456
5MP0001800_abnormal_humoral_immune2.86932556
6MP0005369_muscle_phenotype2.80683897
7MP0001790_abnormal_immune_system2.73716783
8MP0005387_immune_system_phenotype2.73716783
9MP0005330_cardiomyopathy2.73227104
10MP0000703_abnormal_thymus_morphology2.54666756
11MP0004233_abnormal_muscle_weight2.49508361
12MP0004215_abnormal_myocardial_fiber2.45585804
13MP0000750_abnormal_muscle_regeneration2.38923550
14MP0001835_abnormal_antigen_presentation2.38266708
15MP0005360_urolithiasis2.35204979
16MP0005671_abnormal_response_to2.25506955
17MP0002398_abnormal_bone_marrow2.25428904
18MP0002723_abnormal_immune_serum2.23559184
19MP0002420_abnormal_adaptive_immunity2.18394680
20MP0002396_abnormal_hematopoietic_system2.16859341
21MP0001819_abnormal_immune_cell2.13054010
22MP0006036_abnormal_mitochondrial_physio2.12853792
23MP0002166_altered_tumor_susceptibility2.06134442
24MP0000716_abnormal_immune_system2.03201165
25MP0002452_abnormal_antigen_presenting2.02486179
26MP0002972_abnormal_cardiac_muscle2.01645708
27MP0005085_abnormal_gallbladder_physiolo2.01049775
28MP0002006_tumorigenesis1.96280273
29MP0003300_gastrointestinal_ulcer1.90370211
30MP0002405_respiratory_system_inflammati1.88355839
31MP0002722_abnormal_immune_system1.87368241
32MP0000689_abnormal_spleen_morphology1.86790965
33MP0005000_abnormal_immune_tolerance1.86000351
34MP0004270_analgesia1.77918162
35MP0002108_abnormal_muscle_morphology1.73388616
36MP0005365_abnormal_bile_salt1.64303686
37MP0009333_abnormal_splenocyte_physiolog1.63671297
38MP0003303_peritoneal_inflammation1.62930168
39MP0009785_altered_susceptibility_to1.60132472
40MP0002429_abnormal_blood_cell1.59236187
41MP0008057_abnormal_DNA_replication1.58772313
42MP0000013_abnormal_adipose_tissue1.56186863
43MP0000604_amyloidosis1.55632515
44MP0003136_yellow_coat_color1.53895979
45MP0005266_abnormal_metabolism1.53686735
46MP0009840_abnormal_foam_cell1.52619426
47MP0002138_abnormal_hepatobiliary_system1.50742797
48MP0010155_abnormal_intestine_physiology1.49389783
49MP0006138_congestive_heart_failure1.47115677
50MP0003329_amyloid_beta_deposits1.44633279
51MP0004859_abnormal_synaptic_plasticity1.44019174
52MP0004947_skin_inflammation1.42593527
53MP0002139_abnormal_hepatobiliary_system1.42012878
54MP0002127_abnormal_cardiovascular_syste1.41492908
55MP0000733_abnormal_muscle_development1.39503901
56MP0004510_myositis1.38731665
57MP0005310_abnormal_salivary_gland1.38177011
58MP0003646_muscle_fatigue1.37848935
59MP0004484_altered_response_of1.36212626
60MP0002269_muscular_atrophy1.35734209
61MP0002419_abnormal_innate_immunity1.34191217
62MP0001845_abnormal_inflammatory_respons1.31469074
63MP0005670_abnormal_white_adipose1.31271114
64MP0005025_abnormal_response_to1.31247795
65MP0002837_dystrophic_cardiac_calcinosis1.29931597
66MP0009765_abnormal_xenobiotic_induced1.29401568
67MP0001544_abnormal_cardiovascular_syste1.27484690
68MP0005385_cardiovascular_system_phenoty1.27484690
69MP0010630_abnormal_cardiac_muscle1.26264169
70MP0003806_abnormal_nucleotide_metabolis1.24983345
71MP0004381_abnormal_hair_follicle1.24220568
72MP0002148_abnormal_hypersensitivity_rea1.24191620
73MP0003436_decreased_susceptibility_to1.23369160
74MP0000749_muscle_degeneration1.22101511
75MP0004185_abnormal_adipocyte_glucose1.21844862
76MP0003137_abnormal_impulse_conducting1.21740042
77MP0003221_abnormal_cardiomyocyte_apopto1.19990102
78MP0000609_abnormal_liver_physiology1.18566049
79MP0000747_muscle_weakness1.15931705
80MP0002933_joint_inflammation1.14475510
81MP0001661_extended_life_span1.13025937
82MP0003724_increased_susceptibility_to1.12074986
83MP0001853_heart_inflammation1.10949124
84MP0000759_abnormal_skeletal_muscle1.09553953
85MP0004782_abnormal_surfactant_physiolog1.08686409
86MP0004036_abnormal_muscle_relaxation1.08379599
87MP0003866_abnormal_defecation1.08067584
88MP0008961_abnormal_basal_metabolism1.06107412
89MP0000751_myopathy1.04585013
90MP0000372_irregular_coat_pigmentation1.03787751
91MP0004808_abnormal_hematopoietic_stem1.02715988
92MP0001873_stomach_inflammation1.02044130
93MP0003950_abnormal_plasma_membrane1.01969933
94MP0005023_abnormal_wound_healing1.01221933
95MP0008469_abnormal_protein_level1.00403713
96MP0008874_decreased_physiological_sensi0.96058883
97MP0004019_abnormal_vitamin_homeostasis0.95944510
98MP0005451_abnormal_body_composition0.93791877
99MP0000858_altered_metastatic_potential0.93142030
100MP0008875_abnormal_xenobiotic_pharmacok0.91929948
101MP0002998_abnormal_bone_remodeling0.90271317
102MP0008775_abnormal_heart_ventricle0.89333948
103MP0002971_abnormal_brown_adipose0.87809391
104MP0002163_abnormal_gland_morphology0.85697728
105MP0004130_abnormal_muscle_cell0.84991107
106MP0003656_abnormal_erythrocyte_physiolo0.83912267
107MP0004085_abnormal_heartbeat0.83367397
108MP0003091_abnormal_cell_migration0.82501140
109MP0006082_CNS_inflammation0.82060323
110MP0003828_pulmonary_edema0.82001468
111MP0003448_altered_tumor_morphology0.79624175
112MP0004043_abnormal_pH_regulation0.79492115
113MP0009763_increased_sensitivity_to0.78611122
114MP0008770_decreased_survivor_rate0.78584765
115MP0004147_increased_porphyrin_level0.78391202
116MP0002106_abnormal_muscle_physiology0.77473359
117MP0001545_abnormal_hematopoietic_system0.77279368
118MP0005397_hematopoietic_system_phenotyp0.77279368
119MP0001986_abnormal_taste_sensitivity0.76911963
120MP0001533_abnormal_skeleton_physiology0.76448616
121MP0005464_abnormal_platelet_physiology0.76031253
122MP0005666_abnormal_adipose_tissue0.75055258
123MP0005076_abnormal_cell_differentiation0.74773914
124MP0002332_abnormal_exercise_endurance0.74674343
125MP0002822_catalepsy0.74452357
126MP0004134_abnormal_chest_morphology0.72950411
127MP0005620_abnormal_muscle_contractility0.72397996
128MP0003705_abnormal_hypodermis_morpholog0.71071167
129MP0006276_abnormal_autonomic_nervous0.70925853
130MP0003690_abnormal_glial_cell0.69940615
131MP0004087_abnormal_muscle_fiber0.69609850
132MP0005375_adipose_tissue_phenotype0.69164694
133MP0002734_abnormal_mechanical_nocicepti0.68214658
134MP0005423_abnormal_somatic_nervous0.67832423
135MP0009278_abnormal_bone_marrow0.66986206
136MP0008873_increased_physiological_sensi0.66726367
137MP0003718_maternal_effect0.65834166
138MP0005253_abnormal_eye_physiology0.65206339
139MP0001984_abnormal_olfaction0.63172804
140MP0002638_abnormal_pupillary_reflex0.61891586
141MP0005410_abnormal_fertilization0.61376489
142MP0000003_abnormal_adipose_tissue0.60438667
143MP0001529_abnormal_vocalization0.59624329
144MP0005376_homeostasis/metabolism_phenot0.57587268
145MP0005083_abnormal_biliary_tract0.55261193
146MP0002277_abnormal_respiratory_mucosa0.54810627
147MP0009780_abnormal_chondrocyte_physiolo0.53982961
148MP0004142_abnormal_muscle_tone0.52809003
149MP0008789_abnormal_olfactory_epithelium0.52298376
150MP0002234_abnormal_pharynx_morphology0.52255205
151MP0006072_abnormal_retinal_apoptosis0.51018984
152MP0001929_abnormal_gametogenesis0.50410828
153MP0000266_abnormal_heart_morphology0.50026827
154MP0001299_abnormal_eye_distance/0.49097489
155MP0008260_abnormal_autophagy0.48029304
156MP0001764_abnormal_homeostasis0.47550654
157MP0002078_abnormal_glucose_homeostasis0.44335530
158MP0003698_abnormal_male_reproductive0.43675447
159MP0005551_abnormal_eye_electrophysiolog0.43199119
160MP0002210_abnormal_sex_determination0.41081600
161MP0006035_abnormal_mitochondrial_morpho0.38213683
162MP0003879_abnormal_hair_cell0.38012824
163MP0002067_abnormal_sensory_capabilities0.37452473
164MP0002272_abnormal_nervous_system0.35489611
165MP0005332_abnormal_amino_acid0.35356835
166MP0008995_early_reproductive_senescence0.35327519
167MP0006292_abnormal_olfactory_placode0.35051309
168MP0005334_abnormal_fat_pad0.33804349
169MP0008877_abnormal_DNA_methylation0.33521107
170MP0005584_abnormal_enzyme/coenzyme_acti0.32809256
171MP0002066_abnormal_motor_capabilities/c0.32487270
172MP0005452_abnormal_adipose_tissue0.32239189
173MP0002114_abnormal_axial_skeleton0.31743044
174MP0005535_abnormal_body_temperature0.30030836
175MP0002160_abnormal_reproductive_system0.29886977
176MP0009250_abnormal_appendicular_skeleto0.29515756
177MP0005167_abnormal_blood-brain_barrier0.28971724

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.76525149
2Abnormality of T cell number (HP:0011839)5.42122607
3Hydroxyprolinuria (HP:0003080)4.79305780
4Abnormality of proline metabolism (HP:0010907)4.79305780
5Abnormality of the calf musculature (HP:0001430)4.65012486
6Muscle fiber splitting (HP:0003555)4.59787255
7Abnormality of the left ventricular outflow tract (HP:0011103)4.35704219
8Subaortic stenosis (HP:0001682)4.35704219
9Ulnar deviation of the wrist (HP:0003049)4.26855336
10Neck muscle weakness (HP:0000467)4.15299932
11Muscle fiber inclusion bodies (HP:0100299)4.00625383
12Abnormality of skeletal muscle fiber size (HP:0012084)3.96851664
13Centrally nucleated skeletal muscle fibers (HP:0003687)3.93185071
14Elevated erythrocyte sedimentation rate (HP:0003565)3.83953669
15Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.80051304
16Panhypogammaglobulinemia (HP:0003139)3.63908282
17Muscle stiffness (HP:0003552)3.61603975
18Recurrent viral infections (HP:0004429)3.58271777
19Combined immunodeficiency (HP:0005387)3.50759940
20Nemaline bodies (HP:0003798)3.50253813
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.47506103
22Sudden death (HP:0001699)3.44780028
23Severe combined immunodeficiency (HP:0004430)3.44568823
24Exercise-induced muscle cramps (HP:0003710)3.43135121
25Absent phalangeal crease (HP:0006109)3.41571641
26Myotonia (HP:0002486)3.33621332
27Abnormality of T cells (HP:0002843)3.32142152
28Increased variability in muscle fiber diameter (HP:0003557)3.25223822
29Exercise-induced myalgia (HP:0003738)3.24789207
30Recurrent fungal infections (HP:0002841)3.02838507
31Abnormality of the lower motor neuron (HP:0002366)3.00837699
32Areflexia of lower limbs (HP:0002522)3.00795549
33Growth hormone excess (HP:0000845)3.00292732
34Abnormal delayed hypersensitivity skin test (HP:0002963)2.99765986
35Bundle branch block (HP:0011710)2.97963866
36Peritonitis (HP:0002586)2.95785484
37B lymphocytopenia (HP:0010976)2.84981994
38Abnormality of B cell number (HP:0010975)2.84981994
39Type 1 muscle fiber predominance (HP:0003803)2.77827966
40Deep venous thrombosis (HP:0002625)2.76761097
41Eosinophilia (HP:0001880)2.73788709
42Abnormal finger flexion creases (HP:0006143)2.72946421
43Abnormality of the neuromuscular junction (HP:0003398)2.72089785
44Fatigable weakness (HP:0003473)2.72089785
45Recurrent bronchitis (HP:0002837)2.71265505
46Myocardial infarction (HP:0001658)2.69578645
47Asymmetric septal hypertrophy (HP:0001670)2.68984318
48EMG: neuropathic changes (HP:0003445)2.66345954
49Round ear (HP:0100830)2.66230083
50Eczematoid dermatitis (HP:0000976)2.66128595
51Nasal polyposis (HP:0100582)2.64386658
52Type 2 muscle fiber atrophy (HP:0003554)2.63749037
53Generalized muscle weakness (HP:0003324)2.60075461
54Menstrual irregularities (HP:0000858)2.58758299
55Distal lower limb muscle weakness (HP:0009053)2.58373396
56Pustule (HP:0200039)2.52995838
57Distal arthrogryposis (HP:0005684)2.49966411
58Shoulder girdle muscle weakness (HP:0003547)2.48317731
59Frequent falls (HP:0002359)2.47942732
60Leukocytosis (HP:0001974)2.47735767
61Muscle hypertrophy of the lower extremities (HP:0008968)2.47045898
62Fetal akinesia sequence (HP:0001989)2.45993024
63Limb-girdle muscle atrophy (HP:0003797)2.45983198
64Scapular winging (HP:0003691)2.45691910
65Amyotrophic lateral sclerosis (HP:0007354)2.45190741
66Weak cry (HP:0001612)2.43160457
67Papilloma (HP:0012740)2.40154425
68Verrucae (HP:0200043)2.40154425
69Gowers sign (HP:0003391)2.39582797
70Muscle fiber atrophy (HP:0100295)2.39098510
71Dilated cardiomyopathy (HP:0001644)2.38242665
72Abnormality of eosinophils (HP:0001879)2.34581861
73Abnormality of the fingertips (HP:0001211)2.33574657
74Increased purine levels (HP:0004368)2.31917612
75Hyperuricemia (HP:0002149)2.31917612
76IgG deficiency (HP:0004315)2.31649351
77Chronic otitis media (HP:0000389)2.26834645
78Abnormality of the shoulder girdle musculature (HP:0001435)2.26730659
79Rimmed vacuoles (HP:0003805)2.26524266
80Broad palm (HP:0001169)2.25058303
81IgA deficiency (HP:0002720)2.24769716
82Malignant hyperthermia (HP:0002047)2.24466472
83Thyroiditis (HP:0100646)2.22689918
84Hyperphosphatemia (HP:0002905)2.22542830
85Chronic diarrhea (HP:0002028)2.21902989
86Gastrointestinal infarctions (HP:0005244)2.21331433
87Mildly elevated creatine phosphokinase (HP:0008180)2.21110899
88Difficulty running (HP:0009046)2.20997981
89Myopathic facies (HP:0002058)2.20914183
90Joint swelling (HP:0001386)2.18009986
91Muscular dystrophy (HP:0003560)2.17922877
92Nonprogressive disorder (HP:0003680)2.16286282
93Hyporeflexia of lower limbs (HP:0002600)2.13330388
94Progressive muscle weakness (HP:0003323)2.12732581
95Calf muscle hypertrophy (HP:0008981)2.12691239
96Ventricular tachycardia (HP:0004756)2.11827323
97Slender build (HP:0001533)2.11824606
98Exercise intolerance (HP:0003546)2.11623447
99Waddling gait (HP:0002515)2.11558784
100Abnormality of the nasal mucosa (HP:0000433)2.11340743
101EMG: myopathic abnormalities (HP:0003458)2.09846888
102Lipoatrophy (HP:0100578)2.07371341
103Bulbar palsy (HP:0001283)2.06982597
104Proximal amyotrophy (HP:0007126)2.06903171
105Hepatocellular carcinoma (HP:0001402)2.05230555
106Respiratory insufficiency due to muscle weakness (HP:0002747)2.03660428
107Increased connective tissue (HP:0009025)2.03400094
108Stomatitis (HP:0010280)2.03196004
109Granulocytopenia (HP:0001913)2.02676252
110Right ventricular cardiomyopathy (HP:0011663)2.02399096
111Spinal rigidity (HP:0003306)2.02037032
112Calcaneovalgus deformity (HP:0001848)2.01704205
113Abnormality of the musculature of the pelvis (HP:0001469)1.99184968
114Abnormality of the hip-girdle musculature (HP:0001445)1.99184968
115Increased intramyocellular lipid droplets (HP:0012240)1.98013635
116Hyperkalemia (HP:0002153)1.97541299
117Ulnar deviation of finger (HP:0009465)1.97349616
118Hip contracture (HP:0003273)1.96666434
119Acute hepatic failure (HP:0006554)1.93813008
120Pelvic girdle muscle weakness (HP:0003749)1.93403926
121Heart block (HP:0012722)1.92863211
122Increased density of long bones (HP:0006392)1.89983611
123Distal lower limb amyotrophy (HP:0008944)1.88670177
124IgM deficiency (HP:0002850)1.88667482
125Aortic aneurysm (HP:0004942)1.87675757
126Abnormality of the calcaneus (HP:0008364)1.85090387
127Emphysema (HP:0002097)1.84315942
128Abnormality of the peritoneum (HP:0002585)1.83569139
129Recurrent cutaneous fungal infections (HP:0011370)1.82610289
130Chronic mucocutaneous candidiasis (HP:0002728)1.82610289
131Fair hair (HP:0002286)1.82384617
132Abnormality of oral frenula (HP:0000190)1.81783621
133Gastrointestinal stroma tumor (HP:0100723)1.81665993
134Autoimmune hemolytic anemia (HP:0001890)1.80919375
135Increased muscle lipid content (HP:0009058)1.79908548
136Abnormality of the foot musculature (HP:0001436)1.78648292
137Large earlobe (HP:0009748)1.76699858
138Difficulty climbing stairs (HP:0003551)1.76329588
139Rhabdomyolysis (HP:0003201)1.75339068
140Deformed tarsal bones (HP:0008119)1.74852095
141Popliteal pterygium (HP:0009756)1.74760916
142Somatic mutation (HP:0001428)1.72967260
143Abnormal atrioventricular conduction (HP:0005150)1.72221889
144Long clavicles (HP:0000890)1.71328198
145Myoglobinuria (HP:0002913)1.71200425
146Gingival bleeding (HP:0000225)1.69102833
147Spontaneous abortion (HP:0005268)1.68886776
148Inflammation of the large intestine (HP:0002037)1.68485394
149Dislocated radial head (HP:0003083)1.66389241
150Lymphopenia (HP:0001888)1.65587923
151Increased IgM level (HP:0003496)1.65282496
152Ragged-red muscle fibers (HP:0003200)1.63378554
153Facial diplegia (HP:0001349)1.60607412
154Foot dorsiflexor weakness (HP:0009027)1.59457948
155Limb-girdle muscle weakness (HP:0003325)1.59150958
156Hepatic necrosis (HP:0002605)1.58622522
157Easy fatigability (HP:0003388)1.51538785
158Paralysis (HP:0003470)1.50758531
159Left ventricular hypertrophy (HP:0001712)1.50274027
160Ventricular arrhythmia (HP:0004308)1.49671486
161Reduced antithrombin III activity (HP:0001976)1.45407692
162Increased CSF lactate (HP:0002490)1.42894266
163Hepatocellular necrosis (HP:0001404)1.42497119
164Hyperglycinuria (HP:0003108)1.42429095
165Steppage gait (HP:0003376)1.41446687
166Cerebral palsy (HP:0100021)1.40856296
167Abnormal mitochondria in muscle tissue (HP:0008316)1.39535695
168Mitochondrial inheritance (HP:0001427)1.38273277
169Acute necrotizing encephalopathy (HP:0006965)1.38104442

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK26.01704233
2PHKG25.71434170
3PHKG15.71434170
4MAP4K14.35556753
5MAP2K63.30173139
6TESK23.29024201
7MUSK3.20542310
8PINK13.14448844
9TXK2.99846211
10GRK62.89955393
11MST42.78805566
12JAK32.57632127
13CDK122.38366314
14TTN2.10878158
15FGFR42.09279926
16FRK2.02152131
17EEF2K2.01790830
18MAP3K71.96736534
19STK101.95749690
20ITK1.88122020
21MAPKAPK31.87108688
22MAP3K131.83403321
23ZAP701.79029363
24CSK1.61158754
25TYK21.57748426
26MAP3K51.55909097
27MAP3K101.48217401
28TGFBR11.47869837
29MAP3K141.43732210
30MAP3K81.39326719
31OBSCN1.33598318
32TRIB31.21838040
33PTK61.21464456
34FES1.18022218
35PKN21.17269984
36TRPM71.17062692
37MARK11.16380036
38MAP2K41.14395404
39SYK1.12615250
40PRKCH1.12448306
41JAK21.10470970
42LCK1.05397775
43ERBB31.04847569
44MAP2K31.03861706
45ALK1.03467226
46JAK11.02450169
47HCK1.02144924
48PRKCQ0.99811081
49CDK80.99426415
50NLK0.98734301
51FGR0.98050815
52CCNB10.98005707
53PRPF4B0.96192499
54SIK10.94967255
55MAPK130.94033725
56SGK30.92125655
57IKBKE0.92003928
58MAP3K110.89258123
59LRRK20.88993710
60TSSK60.88050628
61SIK20.87905659
62EIF2AK30.87185618
63CDK190.86737031
64PRKAA20.86629781
65HIPK20.85015639
66GRK10.84396938
67ICK0.83768201
68EPHA40.82354611
69PDK10.81527683
70DMPK0.80778095
71TYRO30.79679055
72FGFR30.79640687
73TIE10.79527962
74CAMK2G0.79225531
75MOS0.79202664
76CDK90.78052448
77IKBKB0.76828046
78MAPK120.76574674
79DYRK1B0.75265567
80PNCK0.71333221
81PBK0.71173988
82PRKAA10.69275987
83BTK0.68410014
84MAP3K40.67947708
85INSR0.66741347
86TGFBR20.64788772
87WNK10.62050798
88TNK20.61077452
89EPHB10.60295933
90SGK20.58726335
91ROCK10.58419917
92CSF1R0.58366800
93PRKG10.57563287
94MAP4K20.57367687
95DAPK20.57191521
96CAMK2D0.56024018
97PDK20.55683750
98TRIM280.55292002
99MAPK110.53584224
100CAMK2B0.53245037
101MAP2K70.53031809
102RPS6KA40.52417235
103PKN10.52066739
104LIMK10.51237664
105MAPK70.50414278
106CAMK2A0.50209506
107RPS6KB10.48053259
108BCKDK0.45874577
109ARAF0.45512707
110ACVR1B0.43907265
111DAPK30.42760202
112PRKACA0.42269847
113PIK3CA0.41788463
114VRK20.40912237
115CDK40.40420574
116TAF10.40278585
117PRKD20.39898513
118TAOK10.39355617
119IRAK20.38737940
120PIK3CG0.38685319
121CAMK10.38466789
122MAPK40.37862957
123WNK30.37353297
124PDGFRB0.37093095
125AKT20.36980073
126CHUK0.36856147
127PDPK10.36623098
128MARK20.36373581
129MARK30.36185954
130FGFR10.35214725
131NTRK30.34895526
132IRAK10.34583506
133PRKACB0.34481900
134MAP3K90.34315965
135MELK0.34142754
136ADRBK20.33054682
137MAPK80.32093650
138PIM10.31709490
139NEK90.31377707
140FYN0.31226514
141NTRK20.31195461
142ROCK20.31114532
143VRK10.31113940
144NEK10.30999647
145KDR0.30750102
146LYN0.30044817
147BMPR1B0.29270450
148PRKCB0.28403165
149TBK10.28315650
150STK38L0.28272924
151KSR20.27374244
152DYRK30.27119480
153MAPK30.27035453
154TEC0.26471081
155RPS6KA10.25947003
156MAP2K10.25894421
157NME10.25746806
158CAMK40.25666409
159CSNK1G10.25407483
160SIK30.23908752
161RIPK10.22256428
162SGK10.21972483
163RPS6KA30.18669910
164RPS6KB20.16915219
165PRKACG0.16348531
166CSNK1A1L0.16301041
167DYRK20.16124878
168PRKD10.15769307
169SGK2230.14673353
170SGK4940.14673353
171MAP3K60.14614216
172CSNK1G30.14058546
173CSNK1G20.13536159
174INSRR0.12816869
175BRAF0.12703073

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004006.77852834
2Primary immunodeficiency_Homo sapiens_hsa053404.83318890
3Cardiac muscle contraction_Homo sapiens_hsa042604.66415011
4T cell receptor signaling pathway_Homo sapiens_hsa046603.53035931
5Circadian rhythm_Homo sapiens_hsa047103.05780811
6Parkinsons disease_Homo sapiens_hsa050122.55776856
7Oxidative phosphorylation_Homo sapiens_hsa001902.38509232
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.31786282
9Propanoate metabolism_Homo sapiens_hsa006402.18362078
10Arginine and proline metabolism_Homo sapiens_hsa003302.04527643
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.03497510
12Osteoclast differentiation_Homo sapiens_hsa043801.93852664
13Alzheimers disease_Homo sapiens_hsa050101.92727094
14Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.91971782
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.89389029
16Phototransduction_Homo sapiens_hsa047441.88646314
17Carbon metabolism_Homo sapiens_hsa012001.88065713
18B cell receptor signaling pathway_Homo sapiens_hsa046621.87872619
19Calcium signaling pathway_Homo sapiens_hsa040201.84986771
20Arginine biosynthesis_Homo sapiens_hsa002201.84938445
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.83650732
22Huntingtons disease_Homo sapiens_hsa050161.77375085
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73276114
24Pentose phosphate pathway_Homo sapiens_hsa000301.67443448
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.64116664
26Dorso-ventral axis formation_Homo sapiens_hsa043201.63807652
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.63011992
28Nitrogen metabolism_Homo sapiens_hsa009101.60560050
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.60114735
30Regulation of autophagy_Homo sapiens_hsa041401.58453769
31Antigen processing and presentation_Homo sapiens_hsa046121.55625620
32TNF signaling pathway_Homo sapiens_hsa046681.54913452
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.53399305
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.47305986
35Measles_Homo sapiens_hsa051621.46816105
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45882489
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.44865320
38Fructose and mannose metabolism_Homo sapiens_hsa000511.44863905
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.43629068
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37982134
41Basal transcription factors_Homo sapiens_hsa030221.34929371
42AMPK signaling pathway_Homo sapiens_hsa041521.34202070
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.27548804
44Viral myocarditis_Homo sapiens_hsa054161.24382516
45Pyruvate metabolism_Homo sapiens_hsa006201.24361689
46Prolactin signaling pathway_Homo sapiens_hsa049171.21715357
47Acute myeloid leukemia_Homo sapiens_hsa052211.20460592
48Leishmaniasis_Homo sapiens_hsa051401.19693098
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19140470
50Phenylalanine metabolism_Homo sapiens_hsa003601.17021569
51Hematopoietic cell lineage_Homo sapiens_hsa046401.14974513
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11323478
53Toxoplasmosis_Homo sapiens_hsa051451.09952485
54Fatty acid degradation_Homo sapiens_hsa000711.07835269
55Notch signaling pathway_Homo sapiens_hsa043301.07826744
56Chemokine signaling pathway_Homo sapiens_hsa040621.06161573
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02578133
58HTLV-I infection_Homo sapiens_hsa051661.01439792
59Butanoate metabolism_Homo sapiens_hsa006501.01085872
60Starch and sucrose metabolism_Homo sapiens_hsa005000.99605592
61FoxO signaling pathway_Homo sapiens_hsa040680.97994487
62Complement and coagulation cascades_Homo sapiens_hsa046100.91495383
63Non-small cell lung cancer_Homo sapiens_hsa052230.91231062
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.91200733
65Olfactory transduction_Homo sapiens_hsa047400.90675207
66Colorectal cancer_Homo sapiens_hsa052100.89273027
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87625445
68beta-Alanine metabolism_Homo sapiens_hsa004100.87394843
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86842663
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86317420
71Peroxisome_Homo sapiens_hsa041460.83780617
72Chronic myeloid leukemia_Homo sapiens_hsa052200.82611075
73Insulin resistance_Homo sapiens_hsa049310.82179878
74Prostate cancer_Homo sapiens_hsa052150.79741873
75Endometrial cancer_Homo sapiens_hsa052130.79103599
76Purine metabolism_Homo sapiens_hsa002300.78465497
77Gastric acid secretion_Homo sapiens_hsa049710.78360625
78Oxytocin signaling pathway_Homo sapiens_hsa049210.78339895
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.76047366
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75771886
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73600167
82Hepatitis B_Homo sapiens_hsa051610.73539867
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72737721
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.71369655
85Tight junction_Homo sapiens_hsa045300.70784755
86Shigellosis_Homo sapiens_hsa051310.70173721
87Tryptophan metabolism_Homo sapiens_hsa003800.69993764
88Circadian entrainment_Homo sapiens_hsa047130.68916631
89MAPK signaling pathway_Homo sapiens_hsa040100.68433588
90RNA degradation_Homo sapiens_hsa030180.67192707
91Insulin secretion_Homo sapiens_hsa049110.67145499
92Fatty acid metabolism_Homo sapiens_hsa012120.66664170
93Adherens junction_Homo sapiens_hsa045200.66600086
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65660583
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65352225
96VEGF signaling pathway_Homo sapiens_hsa043700.64931976
97Apoptosis_Homo sapiens_hsa042100.64436614
98Staphylococcus aureus infection_Homo sapiens_hsa051500.63737064
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63229420
100Prion diseases_Homo sapiens_hsa050200.63122609
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61455459
102Ovarian steroidogenesis_Homo sapiens_hsa049130.60714695
103Biosynthesis of amino acids_Homo sapiens_hsa012300.59402927
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58936000
105Proteoglycans in cancer_Homo sapiens_hsa052050.57749867
106Lysine degradation_Homo sapiens_hsa003100.56875170
107Allograft rejection_Homo sapiens_hsa053300.56607527
108GnRH signaling pathway_Homo sapiens_hsa049120.55678612
109Sulfur relay system_Homo sapiens_hsa041220.55366017
110Renin secretion_Homo sapiens_hsa049240.55280582
111Pancreatic cancer_Homo sapiens_hsa052120.55220416
112GABAergic synapse_Homo sapiens_hsa047270.55165385
113Oocyte meiosis_Homo sapiens_hsa041140.53630018
114RNA polymerase_Homo sapiens_hsa030200.53407241
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53376518
116mTOR signaling pathway_Homo sapiens_hsa041500.52816789
117Caffeine metabolism_Homo sapiens_hsa002320.51979156
118Linoleic acid metabolism_Homo sapiens_hsa005910.51604237
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50901100
120Rap1 signaling pathway_Homo sapiens_hsa040150.50045333
121PPAR signaling pathway_Homo sapiens_hsa033200.48575791
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47642022
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47452733
124Insulin signaling pathway_Homo sapiens_hsa049100.47014033
125Glioma_Homo sapiens_hsa052140.46905619
126Platelet activation_Homo sapiens_hsa046110.46665905
127Nicotine addiction_Homo sapiens_hsa050330.46397091
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45609559
129Dilated cardiomyopathy_Homo sapiens_hsa054140.45581310
130ABC transporters_Homo sapiens_hsa020100.45400179
131Choline metabolism in cancer_Homo sapiens_hsa052310.45361866
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45311179
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44576918
134Influenza A_Homo sapiens_hsa051640.43351783
135Viral carcinogenesis_Homo sapiens_hsa052030.41715887
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.41712204
137Metabolic pathways_Homo sapiens_hsa011000.41559698
138ErbB signaling pathway_Homo sapiens_hsa040120.41489219
139Histidine metabolism_Homo sapiens_hsa003400.41314862
140Small cell lung cancer_Homo sapiens_hsa052220.41165980
141Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40519993
142alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40075620
143Rheumatoid arthritis_Homo sapiens_hsa053230.39502146
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38235992
145Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37731056
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37676528
147Renal cell carcinoma_Homo sapiens_hsa052110.37139914
148Epstein-Barr virus infection_Homo sapiens_hsa051690.36908744
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.36169485
150Salivary secretion_Homo sapiens_hsa049700.36049319
151Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35867730
152Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35849136
153Nucleotide excision repair_Homo sapiens_hsa034200.35791694
154Focal adhesion_Homo sapiens_hsa045100.35407649
155Taste transduction_Homo sapiens_hsa047420.35372800
156Proteasome_Homo sapiens_hsa030500.35201868
157Estrogen signaling pathway_Homo sapiens_hsa049150.34855960
158Long-term potentiation_Homo sapiens_hsa047200.32565202
159Tuberculosis_Homo sapiens_hsa051520.32203734
160Glucagon signaling pathway_Homo sapiens_hsa049220.31993847
161Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31207681
162Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30091992
163Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.25368619
164Long-term depression_Homo sapiens_hsa047300.24026356
165Morphine addiction_Homo sapiens_hsa050320.22721372
166Fatty acid elongation_Homo sapiens_hsa000620.20499586
167Cholinergic synapse_Homo sapiens_hsa047250.20020772
168cAMP signaling pathway_Homo sapiens_hsa040240.19437372
169Amphetamine addiction_Homo sapiens_hsa050310.19164983
170Ribosome_Homo sapiens_hsa030100.18434609
171Dopaminergic synapse_Homo sapiens_hsa047280.17838856
172Folate biosynthesis_Homo sapiens_hsa007900.16411096
173Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16105120

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »