PGR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.63791182
2COPI coating of Golgi vesicle (GO:0048205)5.63791182
3mammary gland epithelial cell differentiation (GO:0060644)5.32552965
4vocalization behavior (GO:0071625)5.31126706
5synaptic vesicle exocytosis (GO:0016079)5.30769854
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.28783266
7desmosome organization (GO:0002934)5.16928770
8prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.13870398
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.10593278
10locomotory exploration behavior (GO:0035641)5.08685281
11mammary gland alveolus development (GO:0060749)5.07834935
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.92183790
13iron ion import (GO:0097286)4.90287804
14neuron cell-cell adhesion (GO:0007158)4.90160039
15glutamate secretion (GO:0014047)4.87358185
16biotin metabolic process (GO:0006768)4.77289249
17regulation of glutamate receptor signaling pathway (GO:1900449)4.71526280
18activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)4.69567371
19synaptic vesicle maturation (GO:0016188)4.69046193
20growth hormone receptor signaling pathway (GO:0060396)4.58238059
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.55757550
22cardiac right ventricle morphogenesis (GO:0003215)4.53338077
23ionotropic glutamate receptor signaling pathway (GO:0035235)4.50089491
24regulation of water loss via skin (GO:0033561)4.49875945
25regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.48872173
26negative regulation of execution phase of apoptosis (GO:1900118)4.47733103
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.45373478
28glucocorticoid metabolic process (GO:0008211)4.41527347
29COPII vesicle coating (GO:0048208)4.38906049
30protein localization to synapse (GO:0035418)4.38555974
31neuronal action potential propagation (GO:0019227)4.38346276
32regulation of synaptic vesicle exocytosis (GO:2000300)4.32137122
33response to histamine (GO:0034776)4.30409331
34intestinal epithelial cell development (GO:0060576)4.28671698
35bundle of His cell to Purkinje myocyte communication (GO:0086069)4.19310652
36positive regulation of respiratory burst (GO:0060267)4.18961120
37glutamate receptor signaling pathway (GO:0007215)4.15847466
38cellular response to growth hormone stimulus (GO:0071378)4.15768456
39synaptic vesicle docking involved in exocytosis (GO:0016081)4.14541694
40exploration behavior (GO:0035640)4.14218135
41exocrine pancreas development (GO:0031017)4.13343053
42regulation of synapse structural plasticity (GO:0051823)4.06871473
43insulin-like growth factor receptor signaling pathway (GO:0048009)4.05952317
44regulation of long-term neuronal synaptic plasticity (GO:0048169)4.05330471
45neurotransmitter secretion (GO:0007269)4.03240155
46neuron-neuron synaptic transmission (GO:0007270)4.02571152
47carnitine transport (GO:0015879)4.02326862
48amino-acid betaine transport (GO:0015838)4.02326862
49macroautophagy (GO:0016236)3.93584770
50glandular epithelial cell differentiation (GO:0002067)3.90026677
51synaptic transmission, glutamatergic (GO:0035249)3.86151193
52oocyte development (GO:0048599)3.84242497
53regulation of neuronal synaptic plasticity (GO:0048168)3.83051800
54regulation of hippo signaling (GO:0035330)3.82724915
55gamma-aminobutyric acid signaling pathway (GO:0007214)3.80618972
56lung lobe morphogenesis (GO:0060463)3.77239789
57long-term memory (GO:0007616)3.73171421
58regulation of synaptic vesicle transport (GO:1902803)3.72566272
59regulation of excitatory postsynaptic membrane potential (GO:0060079)3.71982049
60layer formation in cerebral cortex (GO:0021819)3.68632490
61neurotransmitter-gated ion channel clustering (GO:0072578)3.60381656
62gamma-aminobutyric acid transport (GO:0015812)3.56256821
63long-term synaptic potentiation (GO:0060291)3.56065072
64regulation of postsynaptic membrane potential (GO:0060078)3.54746688
65dendritic spine morphogenesis (GO:0060997)3.52178732
66neuron recognition (GO:0008038)3.51901981
67purine nucleotide transport (GO:0015865)3.47481433
68diol metabolic process (GO:0034311)3.44751039
69negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.44232188
70proline transport (GO:0015824)3.43413759
71amyloid precursor protein catabolic process (GO:0042987)3.42697781
72postsynaptic membrane organization (GO:0001941)3.42323411
73presynaptic membrane assembly (GO:0097105)3.40701167
74NLS-bearing protein import into nucleus (GO:0006607)3.38029719
75establishment of skin barrier (GO:0061436)3.37636011
76positive regulation of membrane potential (GO:0045838)3.37068176
77uterus development (GO:0060065)3.35022311
78regulation of synaptic plasticity (GO:0048167)3.34983440
79neurotransmitter transport (GO:0006836)3.34665096
80regulation of dendritic spine morphogenesis (GO:0061001)3.32878423
81retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.30211736
82G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.29860559
83regulation of synaptic transmission, glutamatergic (GO:0051966)3.29102442
84positive regulation of synapse maturation (GO:0090129)3.28641661
85negative regulation of synaptic transmission, GABAergic (GO:0032229)3.28444793
86regulation of establishment or maintenance of cell polarity (GO:0032878)3.26997201
87membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.25687602
88auditory behavior (GO:0031223)3.25417422
89mating behavior (GO:0007617)3.24725452
90cellular potassium ion homeostasis (GO:0030007)3.24343655
91positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.24052633
92regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.23062973
93prepulse inhibition (GO:0060134)3.22750618
94multicellular organismal water homeostasis (GO:0050891)3.18860879
95tight junction assembly (GO:0070830)3.17868503
96positive regulation of neurotransmitter secretion (GO:0001956)3.17593698
97positive regulation of neurotransmitter transport (GO:0051590)3.17027361
98activation of protein kinase A activity (GO:0034199)3.16837227
99synaptic transmission, dopaminergic (GO:0001963)3.16710861
100positive regulation of synaptic transmission, GABAergic (GO:0032230)3.16489932
101regulation of neurotransmitter levels (GO:0001505)3.15782261
102regulation of vesicle fusion (GO:0031338)3.15116802
103axonal fasciculation (GO:0007413)3.14483224
104trivalent inorganic anion homeostasis (GO:0072506)3.13558749
105phosphate ion homeostasis (GO:0055062)3.13558749
106presynaptic membrane organization (GO:0097090)3.11432625
107xenobiotic catabolic process (GO:0042178)3.09736435
108JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.09437366
109carnitine shuttle (GO:0006853)3.08783024
110sphingoid metabolic process (GO:0046519)3.08710669
111negative regulation of complement activation (GO:0045916)3.07700341
112outflow tract septum morphogenesis (GO:0003148)3.07244579
113G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.05061377
114positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.02039004
115amyloid precursor protein metabolic process (GO:0042982)3.01502537
116vesicle coating (GO:0006901)3.01162467
117membrane depolarization (GO:0051899)3.00705827
118ER overload response (GO:0006983)3.00430115
119regulation of glutamate secretion (GO:0014048)3.00137946
120regulation of dendritic spine development (GO:0060998)2.99370496
121neuromuscular process controlling balance (GO:0050885)2.98897408
122regulation of acrosome reaction (GO:0060046)2.98658997
123water homeostasis (GO:0030104)2.98607001
124regulation of neurotransmitter secretion (GO:0046928)2.95789945
125regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.95115156
126quaternary ammonium group transport (GO:0015697)2.94470805
127learning (GO:0007612)2.93708144
128columnar/cuboidal epithelial cell development (GO:0002066)2.93576076
129positive regulation of synapse assembly (GO:0051965)2.93519390
130synapse assembly (GO:0007416)2.92343574
131response to auditory stimulus (GO:0010996)2.92098162
132transmission of nerve impulse (GO:0019226)2.91890439
133cardiac ventricle morphogenesis (GO:0003208)2.91721276
134positive regulation of synaptic transmission (GO:0050806)2.88971991
135startle response (GO:0001964)2.88949850
136synaptic vesicle endocytosis (GO:0048488)2.87055335
137short-chain fatty acid metabolic process (GO:0046459)2.86822581
138cytoskeletal anchoring at plasma membrane (GO:0007016)2.86570546
139behavioral response to cocaine (GO:0048148)2.86482466
140positive regulation of macroautophagy (GO:0016239)2.85685647
141cellular zinc ion homeostasis (GO:0006882)2.84814416
142synaptic transmission (GO:0007268)2.84263498
143lung secretory cell differentiation (GO:0061140)2.84256071
144regulation of neurotransmitter transport (GO:0051588)2.83147518
145interleukin-6-mediated signaling pathway (GO:0070102)2.83113112
146embryo implantation (GO:0007566)2.82232137
147cellular response to ammonium ion (GO:0071242)2.81858625
148regulation of autophagic vacuole assembly (GO:2000785)2.81497379
149cerebellar Purkinje cell differentiation (GO:0021702)2.80873222
150neuromuscular process controlling posture (GO:0050884)2.80854898
151mechanosensory behavior (GO:0007638)2.78970432
152synapse organization (GO:0050808)2.78582815
153membrane hyperpolarization (GO:0060081)2.78036809
154positive regulation of glycolytic process (GO:0045821)2.77514247
155heparin biosynthetic process (GO:0030210)2.77116032
156heparin metabolic process (GO:0030202)2.77116032
157regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.77048700
158behavioral defense response (GO:0002209)2.76819876
159behavioral fear response (GO:0001662)2.76819876
160intraspecies interaction between organisms (GO:0051703)2.76581434
161social behavior (GO:0035176)2.76581434
162sodium ion export (GO:0071436)2.76426227
163innervation (GO:0060384)2.76030419
164long term synaptic depression (GO:0060292)2.74054904
165regulation of synaptic transmission (GO:0050804)2.73485111
166righting reflex (GO:0060013)2.73453092
167regulation of establishment of cell polarity (GO:2000114)2.71992970
168negative regulation of cell size (GO:0045792)2.70897303
169positive regulation of nitric-oxide synthase activity (GO:0051000)2.70480875
170positive regulation of glycogen biosynthetic process (GO:0045725)2.70056325
171ear development (GO:0043583)2.69992181
172face development (GO:0060324)2.66366437
173carnitine transmembrane transport (GO:1902603)2.65589299
174endocrine hormone secretion (GO:0060986)2.64045922
175regulation of extracellular matrix disassembly (GO:0010715)2.63493460
176negative regulation of multicellular organism growth (GO:0040015)2.63294262
177nitric oxide biosynthetic process (GO:0006809)2.62980385
178epithelial cell-cell adhesion (GO:0090136)2.62803836
179ectoderm development (GO:0007398)2.62377306
180response to nitrosative stress (GO:0051409)2.62165857
181urinary tract smooth muscle contraction (GO:0014848)2.61645726
182regulation of cell proliferation involved in kidney development (GO:1901722)2.61601283
183sphingomyelin metabolic process (GO:0006684)2.60851048
184positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.60486034
185norepinephrine metabolic process (GO:0042415)2.60352962
186tonic smooth muscle contraction (GO:0014820)2.59152938
187positive regulation of hormone metabolic process (GO:0032352)2.54699401
188regulation of protein glycosylation (GO:0060049)2.54652559
189regulation of type B pancreatic cell apoptotic process (GO:2000674)2.54368204
190* epithelial cell maturation (GO:0002070)2.54331943
191branching involved in prostate gland morphogenesis (GO:0060442)2.54003909
192positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.53191880
193type B pancreatic cell proliferation (GO:0044342)2.53127103
194negative regulation of cytosolic calcium ion concentration (GO:0051481)2.53058307
195cellular response to antibiotic (GO:0071236)2.52689044
196positive regulation of response to nutrient levels (GO:0032109)2.51195561
197positive regulation of response to extracellular stimulus (GO:0032106)2.51195561
198phosphatidylinositol 3-kinase signaling (GO:0014065)2.49402624
199regulation of histone H3-K27 methylation (GO:0061085)2.48937629
200prostate gland growth (GO:0060736)10.2704074

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.68915098
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.28848730
3ESR1_21235772_ChIP-Seq_MCF-7_Human5.24262448
4ESR2_21235772_ChIP-Seq_MCF-7_Human4.56749424
5GBX2_23144817_ChIP-Seq_PC3_Human3.56764755
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.27974695
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.16226537
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.13578234
9* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.03836988
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78996392
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78996392
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.77297227
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.71231619
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59047008
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58413688
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49564723
17GATA3_24758297_ChIP-Seq_MCF-7_Human2.46713791
18* FOXM1_26456572_ChIP-Seq_MCF-7_Human2.44927542
19ELF5_23300383_ChIP-Seq_T47D_Human2.44330133
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42155803
21* EZH2_27304074_Chip-Seq_ESCs_Mouse2.39232706
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.34806726
23TAF15_26573619_Chip-Seq_HEK293_Human2.33178843
24ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.28753718
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.26173369
26DROSHA_22980978_ChIP-Seq_HELA_Human2.24859727
27REST_21632747_ChIP-Seq_MESCs_Mouse2.16835716
28* RARB_27405468_Chip-Seq_BRAIN_Mouse2.14471370
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11452987
30RUNX1_27514584_Chip-Seq_MCF-7_Human2.10106933
31RNF2_27304074_Chip-Seq_ESCs_Mouse2.07131800
32EZH2_27294783_Chip-Seq_ESCs_Mouse2.03615623
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95766672
34* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92451885
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.90876600
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.88268466
37AR_21572438_ChIP-Seq_LNCaP_Human1.82980180
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72886898
39* KDM5A_27292631_Chip-Seq_BREAST_Human1.71394421
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68419136
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.68058678
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.65575378
43FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.65243672
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62061351
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.61762374
46* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.60594639
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58656368
48P300_19829295_ChIP-Seq_ESCs_Human1.58232960
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57737969
50FOXA1_25552417_ChIP-Seq_VCAP_Human1.56715878
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.56319745
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55406013
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55286384
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.55099095
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.54780586
56RACK7_27058665_Chip-Seq_MCF-7_Human1.53375016
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.52104107
58ZNF263_19887448_ChIP-Seq_K562_Human1.49704258
59ZNF274_21170338_ChIP-Seq_K562_Hela1.48367965
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47752082
61HOXB7_26014856_ChIP-Seq_BT474_Human1.45069853
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.44905669
63* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44667492
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.42554144
65* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42050479
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41891387
67GATA6_25053715_ChIP-Seq_YYC3_Human1.39342796
68* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39293008
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38159151
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36175555
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35971604
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35642755
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35545752
74CHD1_26751641_Chip-Seq_LNCaP_Human1.33864979
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33166475
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.32955727
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.31561706
78* AR_25329375_ChIP-Seq_VCAP_Human1.30782339
79* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29284824
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28241748
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27994954
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27089583
83SOX2_20726797_ChIP-Seq_SW620_Human1.26581860
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25724080
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.25092776
86FUS_26573619_Chip-Seq_HEK293_Human1.24868657
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.24080286
88POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22875014
89* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22845590
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.22230262
91AHR_22903824_ChIP-Seq_MCF-7_Human1.22142070
92FOXA2_19822575_ChIP-Seq_HepG2_Human1.19895005
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19270976
94TFEB_21752829_ChIP-Seq_HELA_Human1.18744539
95LXR_22158963_ChIP-Seq_LIVER_Mouse1.17699029
96TP53_16413492_ChIP-PET_HCT116_Human1.17540513
97CBX2_27304074_Chip-Seq_ESCs_Mouse1.17333048
98TP53_18474530_ChIP-ChIP_U2OS_Human1.16040259
99AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15528128
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15441622
101RXR_22158963_ChIP-Seq_LIVER_Mouse1.15130713
102FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15056364
103WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14652543
104STAT3_23295773_ChIP-Seq_U87_Human1.13606089
105PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13589724
106BCAT_22108803_ChIP-Seq_LS180_Human1.13454404
107ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.11756591
108NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10343998
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10256793
110FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10170984
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09479425
112GATA4_25053715_ChIP-Seq_YYC3_Human1.08835232
113CLOCK_20551151_ChIP-Seq_293T_Human1.08734074
114AR_19668381_ChIP-Seq_PC3_Human1.08598701
115FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.08581577
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08078118
117* CBP_21632823_ChIP-Seq_H3396_Human1.06253621
118TCF4_23295773_ChIP-Seq_U87_Human1.05345642
119YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05012285
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04596930
121IGF1R_20145208_ChIP-Seq_DFB_Human1.02728893
122RING1B_27294783_Chip-Seq_NPCs_Mouse1.02653432
123DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02514925
124* ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01667329
125ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01174685
126RUNX2_22187159_ChIP-Seq_PCA_Human0.99640693
127* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99501902
128RNF2_27304074_Chip-Seq_NSC_Mouse0.98586525
129* PRDM14_20953172_ChIP-Seq_ESCs_Human0.98579422
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98176712
131SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97416729
132KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95905336
133MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95350021
134TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93861155
135SMAD3_21741376_ChIP-Seq_HESCs_Human0.93500551
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93396258
137TBX20_22080862_ChIP-Seq_HEART_Mouse0.93045251
138TBX20_22328084_ChIP-Seq_HEART_Mouse0.93045251
139ER_23166858_ChIP-Seq_MCF-7_Human0.93006006
140TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92846436
141RXR_22108803_ChIP-Seq_LS180_Human0.92124650
142STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92028100
143TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90957330
144* KLF5_25053715_ChIP-Seq_YYC3_Human0.90627845
145CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90361572
146P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89319025
147ESR1_20079471_ChIP-ChIP_T-47D_Human0.88471079
148CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87253632
149EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86475114
150CDX2_20551321_ChIP-Seq_CACO-2_Human0.86342515
151JUN_21703547_ChIP-Seq_K562_Human0.85932004
152SMAD3_21741376_ChIP-Seq_ESCs_Human0.85551821
153CDX2_22108803_ChIP-Seq_LS180_Human0.85510439
154TCF4_22108803_ChIP-Seq_LS180_Human0.85066708
155RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.84646575
156PPARA_22158963_ChIP-Seq_LIVER_Mouse0.84637922
157SALL1_21062744_ChIP-ChIP_HESCs_Human0.84521651
158TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84468967
159NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83605452
160EOMES_21245162_ChIP-Seq_HESCs_Human0.83423288
161PKCTHETA_26484144_Chip-Seq_BREAST_Human0.81332833
162SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.80506119
163SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.80506119
164SOX9_24532713_ChIP-Seq_HFSC_Mouse0.79503817
165TBX3_20139965_ChIP-Seq_MESCs_Mouse0.77675661
166TBX3_20139965_ChIP-Seq_ESCs_Mouse0.77185078
167PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.75404036
168EGR1_23403033_ChIP-Seq_LIVER_Mouse0.73079382
169TDRD3_21172665_ChIP-Seq_MCF-7_Human0.69604891
170NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.67836514
171GATA4_21415370_ChIP-Seq_HL-1_Mouse0.67107050
172ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.67020059

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.33759884
2MP0003880_abnormal_central_pattern5.40759457
3MP0005248_abnormal_Harderian_gland5.16030500
4MP0005379_endocrine/exocrine_gland_phen4.83414022
5MP0001346_abnormal_lacrimal_gland4.78843904
6MP0003635_abnormal_synaptic_transmissio4.14383602
7MP0004264_abnormal_extraembryonic_tissu3.88909032
8MP0009745_abnormal_behavioral_response3.42405307
9MP0000427_abnormal_hair_cycle3.39783861
10MP0004270_analgesia3.35214317
11MP0002063_abnormal_learning/memory/cond3.23397546
12MP0002064_seizures3.09235951
13MP0009046_muscle_twitch3.05578411
14MP0001968_abnormal_touch/_nociception3.00144032
15MP0001501_abnormal_sleep_pattern2.93558506
16MP0002572_abnormal_emotion/affect_behav2.86050827
17MP0010678_abnormal_skin_adnexa2.67024324
18MP0002272_abnormal_nervous_system2.59010395
19MP0001486_abnormal_startle_reflex2.45071731
20MP0005083_abnormal_biliary_tract2.40711179
21MP0005408_hypopigmentation2.38255014
22MP0002822_catalepsy2.37420812
23MP0002796_impaired_skin_barrier2.34790760
24MP0002734_abnormal_mechanical_nocicepti2.31799509
25MP0002736_abnormal_nociception_after2.29687591
26MP0001440_abnormal_grooming_behavior2.12122061
27MP0005423_abnormal_somatic_nervous2.09844236
28MP0002735_abnormal_chemical_nociception2.05298673
29* MP0001919_abnormal_reproductive_system2.00743430
30* MP0001881_abnormal_mammary_gland2.00524121
31MP0003941_abnormal_skin_development1.97991768
32MP0009780_abnormal_chondrocyte_physiolo1.96557332
33MP0002733_abnormal_thermal_nociception1.95732571
34MP0000383_abnormal_hair_follicle1.93616505
35* MP0000627_abnormal_mammary_gland1.90310009
36MP0002098_abnormal_vibrissa_morphology1.89405720
37MP0004233_abnormal_muscle_weight1.86329882
38MP0001970_abnormal_pain_threshold1.85404973
39MP0002067_abnormal_sensory_capabilities1.83450502
40MP0000462_abnormal_digestive_system1.79747951
41MP0003329_amyloid_beta_deposits1.76708162
42MP0008569_lethality_at_weaning1.76203212
43MP0002009_preneoplasia1.72215060
44MP0009384_cardiac_valve_regurgitation1.70677178
45* MP0002557_abnormal_social/conspecific_i1.69464938
46MP0002184_abnormal_innervation1.69329060
47MP0006276_abnormal_autonomic_nervous1.68228534
48MP0004924_abnormal_behavior1.67736088
49MP0005386_behavior/neurological_phenoty1.67736088
50* MP0005389_reproductive_system_phenotype1.65551252
51MP0001905_abnormal_dopamine_level1.63601361
52MP0003879_abnormal_hair_cell1.63539768
53MP0001727_abnormal_embryo_implantation1.61859136
54* MP0001944_abnormal_pancreas_morphology1.60044136
55MP0004782_abnormal_surfactant_physiolog1.59007000
56MP0003183_abnormal_peptide_metabolism1.58828035
57MP0001873_stomach_inflammation1.54166097
58MP0002909_abnormal_adrenal_gland1.53853119
59MP0002896_abnormal_bone_mineralization1.51519937
60MP0005646_abnormal_pituitary_gland1.44311422
61MP0001529_abnormal_vocalization1.42106300
62MP0000778_abnormal_nervous_system1.41793645
63MP0004811_abnormal_neuron_physiology1.41171690
64MP0001661_extended_life_span1.40074186
65MP0003283_abnormal_digestive_organ1.36599487
66MP0000604_amyloidosis1.35568477
67MP0004858_abnormal_nervous_system1.32779939
68* MP0003936_abnormal_reproductive_system1.31919122
69* MP0002693_abnormal_pancreas_physiology1.29003701
70MP0002837_dystrophic_cardiac_calcinosis1.28408931
71MP0001664_abnormal_digestion1.28324194
72MP0001188_hyperpigmentation1.27639556
73MP0010386_abnormal_urinary_bladder1.26240615
74MP0010352_gastrointestinal_tract_polyps1.26009307
75MP0002066_abnormal_motor_capabilities/c1.25929198
76MP0004885_abnormal_endolymph1.22870940
77MP0000955_abnormal_spinal_cord1.21957843
78MP0004484_altered_response_of1.20924958
79MP0001502_abnormal_circadian_rhythm1.20750512
80MP0005501_abnormal_skin_physiology1.20703577
81MP0000751_myopathy1.20069488
82MP0008057_abnormal_DNA_replication1.19581008
83MP0005636_abnormal_mineral_homeostasis1.19254522
84MP0000377_abnormal_hair_follicle1.18490536
85MP0004510_myositis1.16622261
86MP0010234_abnormal_vibrissa_follicle1.15557703
87MP0000013_abnormal_adipose_tissue1.15150246
88MP0002882_abnormal_neuron_morphology1.14860243
89MP0001756_abnormal_urination1.13186035
90MP0003633_abnormal_nervous_system1.13046746
91MP0002877_abnormal_melanocyte_morpholog1.12486482
92MP0003122_maternal_imprinting1.12399194
93MP0004742_abnormal_vestibular_system1.11843560
94MP0003191_abnormal_cellular_cholesterol1.09294810
95MP0008874_decreased_physiological_sensi1.09259796
96MP0005220_abnormal_exocrine_pancreas1.08938542
97MP0010329_abnormal_lipoprotein_level1.06958062
98MP0000579_abnormal_nail_morphology1.05574732
99MP0001666_abnormal_nutrient_absorption1.04928173
100MP0003787_abnormal_imprinting1.02591512
101MP0008872_abnormal_physiological_respon1.00145292
102MP0005623_abnormal_meninges_morphology0.99570589
103MP0002108_abnormal_muscle_morphology0.97486297
104MP0001984_abnormal_olfaction0.97292753
105MP0002166_altered_tumor_susceptibility0.97156389
106MP0003631_nervous_system_phenotype0.96421242
107MP0005275_abnormal_skin_tensile0.96007334
108MP0005058_abnormal_lysosome_morphology0.95585772
109MP0004147_increased_porphyrin_level0.94757171
110MP0004142_abnormal_muscle_tone0.93158216
111MP0001177_atelectasis0.91050164
112MP0000681_abnormal_thyroid_gland0.89177395
113MP0000003_abnormal_adipose_tissue0.88133157
114MP0004019_abnormal_vitamin_homeostasis0.87190589
115MP0004381_abnormal_hair_follicle0.87065036
116MP0002152_abnormal_brain_morphology0.86971866
117MP0004085_abnormal_heartbeat0.86240359
118MP0002069_abnormal_eating/drinking_beha0.83571718
119MP0004145_abnormal_muscle_electrophysio0.81811451
120MP0001765_abnormal_ion_homeostasis0.81728518
121MP0005645_abnormal_hypothalamus_physiol0.80192750
122MP0005409_darkened_coat_color0.79439292
123* MP0003953_abnormal_hormone_level0.78248808
124MP0003195_calcinosis0.78215994
125MP0001963_abnormal_hearing_physiology0.77703702
126MP0003075_altered_response_to0.77299391
127MP0005535_abnormal_body_temperature0.77179695
128MP0002168_other_aberrant_phenotype0.75289251
129MP0000538_abnormal_urinary_bladder0.75173745
130* MP0002078_abnormal_glucose_homeostasis0.74990175
131MP0005167_abnormal_blood-brain_barrier0.72866938
132MP0003868_abnormal_feces_composition0.71705390
133MP0005187_abnormal_penis_morphology0.70424257
134MP0005075_abnormal_melanosome_morpholog0.69535061
135MP0000631_abnormal_neuroendocrine_gland0.69211887
136MP0001216_abnormal_epidermal_layer0.68429728
137MP0008004_abnormal_stomach_pH0.67775968
138* MP0003638_abnormal_response/metabolism_0.67197567
139MP0002127_abnormal_cardiovascular_syste0.67127978
140MP0003632_abnormal_nervous_system0.66698567
141MP0005166_decreased_susceptibility_to0.66429664
142MP0002876_abnormal_thyroid_physiology0.66125901
143MP0003943_abnormal_hepatobiliary_system0.65689636
144MP0000470_abnormal_stomach_morphology0.65222960
145MP0005551_abnormal_eye_electrophysiolog0.64326665
146MP0004215_abnormal_myocardial_fiber0.64207003
147MP0002229_neurodegeneration0.63658566
148MP0002163_abnormal_gland_morphology0.63431581
149MP0002295_abnormal_pulmonary_circulatio0.61623077
150MP0004036_abnormal_muscle_relaxation0.60405066
151MP0000920_abnormal_myelination0.60225358
152MP0002090_abnormal_vision0.59837425
153MP0002160_abnormal_reproductive_system0.59796266
154* MP0004883_abnormal_blood_vessel0.59479310
155MP0009703_decreased_birth_body0.59323532
156MP0000566_synostosis0.58403251
157MP0003634_abnormal_glial_cell0.57834957
158MP0002752_abnormal_somatic_nervous0.57304758
159MP0001485_abnormal_pinna_reflex0.56761035
160MP0010771_integument_phenotype0.54887108
161MP0000534_abnormal_ureter_morphology0.53818081
162MP0002282_abnormal_trachea_morphology0.53630299
163MP0000639_abnormal_adrenal_gland0.53523841
164MP0006072_abnormal_retinal_apoptosis0.53184973
165MP0000367_abnormal_coat/_hair0.53122140
166MP0000230_abnormal_systemic_arterial0.52598654
167MP0001943_abnormal_respiration0.52459836
168MP0008961_abnormal_basal_metabolism0.52106471
169MP0002060_abnormal_skin_morphology0.51433540
170MP0003045_fibrosis0.50281877
171MP0003690_abnormal_glial_cell0.49404082
172MP0005595_abnormal_vascular_smooth0.48884215
173* MP0005164_abnormal_response_to0.48071950
174MP0004134_abnormal_chest_morphology0.47235448
175MP0000647_abnormal_sebaceous_gland0.46952393
176MP0001243_abnormal_dermal_layer0.46124964
177MP0003300_gastrointestinal_ulcer0.44154148
178MP0002269_muscular_atrophy0.43755884
179MP0000613_abnormal_salivary_gland0.42620695

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.06355439
2Oligomenorrhea (HP:0000876)6.56736313
3Concave nail (HP:0001598)6.21621388
4Focal seizures (HP:0007359)5.72691261
5Myokymia (HP:0002411)5.66792503
6Sparse lateral eyebrow (HP:0005338)5.26333119
7Visual hallucinations (HP:0002367)5.24167741
8Right ventricular cardiomyopathy (HP:0011663)5.15815014
9Atonic seizures (HP:0010819)4.88440048
10Epileptic encephalopathy (HP:0200134)4.61500899
11Absence seizures (HP:0002121)4.25703410
12Febrile seizures (HP:0002373)4.23209656
13Curly hair (HP:0002212)4.19088902
14Progressive cerebellar ataxia (HP:0002073)4.17531316
15Hyperventilation (HP:0002883)3.95176521
16Broad-based gait (HP:0002136)3.93232439
17Flat capital femoral epiphysis (HP:0003370)3.88688942
18Dialeptic seizures (HP:0011146)3.83423779
19Generalized tonic-clonic seizures (HP:0002069)3.78835340
20Abnormality of nail color (HP:0100643)3.68020678
21Abnormality of the proximal phalanges of the hand (HP:0009834)3.67256560
22Breast carcinoma (HP:0003002)3.61949015
23Macroorchidism (HP:0000053)3.28458862
24Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.27878311
25Pili torti (HP:0003777)3.25067749
26Truncal ataxia (HP:0002078)3.22260079
27Flat acetabular roof (HP:0003180)3.16479735
28Arterial tortuosity (HP:0005116)3.15248646
29Septate vagina (HP:0001153)3.14552065
30Supranuclear gaze palsy (HP:0000605)3.13185260
31Action tremor (HP:0002345)3.12951412
32Gaze-evoked nystagmus (HP:0000640)3.11292529
33Dysdiadochokinesis (HP:0002075)3.04873975
34Menorrhagia (HP:0000132)3.03397086
35Ketoacidosis (HP:0001993)3.02295937
36Progressive inability to walk (HP:0002505)3.01202305
37Amblyopia (HP:0000646)2.96028492
38Poor eye contact (HP:0000817)2.92670473
39Enlarged penis (HP:0000040)2.90755066
40Testicular atrophy (HP:0000029)2.85845508
41Dysmetria (HP:0001310)2.85376167
42Depression (HP:0000716)2.85108218
43Scanning speech (HP:0002168)2.84971191
44Deep philtrum (HP:0002002)2.82716800
45Anxiety (HP:0000739)2.82567732
46Limb dystonia (HP:0002451)2.80898014
47Infantile muscular hypotonia (HP:0008947)2.80395666
48Urinary glycosaminoglycan excretion (HP:0003541)2.80322824
49Mucopolysacchariduria (HP:0008155)2.80322824
50Hyperglycemia (HP:0003074)2.80070971
51Mutism (HP:0002300)2.80033000
52Testicular neoplasm (HP:0010788)2.78976402
53Drooling (HP:0002307)2.78015702
54Excessive salivation (HP:0003781)2.78015702
55Unilateral renal agenesis (HP:0000122)2.76417709
56Congenital glaucoma (HP:0001087)2.74868785
57Vascular tortuosity (HP:0004948)2.74612773
58Cerebral inclusion bodies (HP:0100314)2.67517254
59Hemiplegia (HP:0002301)2.66993569
60Abnormality of the distal phalanges of the toes (HP:0010182)2.66830259
61Hypokinesia (HP:0002375)2.66697069
62Abnormal social behavior (HP:0012433)2.64964474
63Impaired social interactions (HP:0000735)2.64964474
64Hydroureter (HP:0000072)2.64130256
65Broad metatarsal (HP:0001783)2.63485748
66Exostoses (HP:0100777)2.63334648
67Impaired vibration sensation in the lower limbs (HP:0002166)2.58714545
68Abnormality of polysaccharide metabolism (HP:0011012)2.56553720
69Abnormality of glycosaminoglycan metabolism (HP:0004371)2.56553720
70Abnormality of mucopolysaccharide metabolism (HP:0011020)2.56553720
71Hamartoma of the eye (HP:0010568)2.55352161
72Syncope (HP:0001279)2.54422624
73Diplopia (HP:0000651)2.54313229
74Abnormality of binocular vision (HP:0011514)2.54313229
75Impaired smooth pursuit (HP:0007772)2.54194006
76Genetic anticipation (HP:0003743)2.52816255
77Abnormal eating behavior (HP:0100738)2.50616543
78Germ cell neoplasia (HP:0100728)2.49995891
79Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.48556834
80Absent frontal sinuses (HP:0002688)2.48239591
81Tubulointerstitial nephritis (HP:0001970)2.47350843
82Hyporeflexia of lower limbs (HP:0002600)2.46877216
83Papilledema (HP:0001085)2.45001495
84Abnormal glucose tolerance (HP:0001952)2.44965506
85Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.44904424
86Stereotypic behavior (HP:0000733)2.42463850
87Neurofibrillary tangles (HP:0002185)2.42174010
88Conjunctival hamartoma (HP:0100780)2.40238994
89Torticollis (HP:0000473)2.38198474
90Cardiomegaly (HP:0001640)2.35901694
91Hypotension (HP:0002615)2.34995117
92Protruding tongue (HP:0010808)2.32812240
93Inability to walk (HP:0002540)2.32738647
94Absent speech (HP:0001344)2.32097773
95Hypoventilation (HP:0002791)2.32077547
96Glucose intolerance (HP:0000833)2.30732671
97Mitral stenosis (HP:0001718)2.30680437
98Hemiparesis (HP:0001269)2.29957161
99Bundle branch block (HP:0011710)2.29893103
100Vascular calcification (HP:0004934)2.28930063
101Spondylolisthesis (HP:0003302)2.28707306
102Clumsiness (HP:0002312)2.24118820
103Bradykinesia (HP:0002067)2.20285691
104Abnormality of the phalanges of the hallux (HP:0010057)2.20098098
105Abnormality of ocular smooth pursuit (HP:0000617)2.19165704
106Annular pancreas (HP:0001734)2.18067048
107Abnormal hair laboratory examination (HP:0003328)2.17756761
108Diminished movement (HP:0002374)2.16978001
109Palpebral edema (HP:0100540)2.16506044
110Intention tremor (HP:0002080)2.16224738
111Ankle clonus (HP:0011448)2.16201949
112Urinary bladder sphincter dysfunction (HP:0002839)2.15375250
113Asymmetric septal hypertrophy (HP:0001670)2.14854715
114Focal dystonia (HP:0004373)2.14684770
115Abnormal tarsal ossification (HP:0008369)2.13613704
116Postural instability (HP:0002172)2.10982355
117Dysostosis multiplex (HP:0000943)2.08082244
118Abnormality of the distal phalanx of the thumb (HP:0009617)2.07976972
119Abnormality of the epiphyses of the hand (HP:0005924)2.07231187
120Short metatarsal (HP:0010743)2.06443037
121Advanced eruption of teeth (HP:0006288)2.04465332
122Ankyloglossia (HP:0010296)2.04441469
123Ketosis (HP:0001946)2.04268360
124Insulin-resistant diabetes mellitus (HP:0000831)2.03771909
125Gait ataxia (HP:0002066)2.03415367
126Osteoarthritis (HP:0002758)2.03345642
127Hyperkalemia (HP:0002153)2.03026851
128Ventricular tachycardia (HP:0004756)2.02861103
129* Infertility (HP:0000789)2.01977607
130Status epilepticus (HP:0002133)2.00626179
131Abnormality of salivation (HP:0100755)1.99545929
132Epileptiform EEG discharges (HP:0011182)1.99514769
133Cardiovascular calcification (HP:0011915)1.98263005
134Urinary urgency (HP:0000012)1.97994191
135Buphthalmos (HP:0000557)1.96732026
136Microretrognathia (HP:0000308)1.95198370
137Radial bowing (HP:0002986)1.95150246
138Craniofacial dystonia (HP:0012179)1.95124953
139Exotropia (HP:0000577)1.94193476
140Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.94143480
141Ventricular fibrillation (HP:0001663)1.93385199
142Polyphagia (HP:0002591)1.92254667
143Sudden death (HP:0001699)1.90941717
144Blue irides (HP:0000635)1.90741741
145Fetal akinesia sequence (HP:0001989)1.90090383
146Neuroendocrine neoplasm (HP:0100634)1.89851029
147Agitation (HP:0000713)1.89474857
148Akinesia (HP:0002304)1.89391491
149Neoplasm of the heart (HP:0100544)1.88996470
150Abnormality of the dental root (HP:0006486)1.88913274
151Taurodontia (HP:0000679)1.88913274
152Abnormality of permanent molar morphology (HP:0011071)1.88913274
153Striae distensae (HP:0001065)1.88884663
154Generalized myoclonic seizures (HP:0002123)1.88862395
155Neuronal loss in central nervous system (HP:0002529)1.87732380
156Short 1st metacarpal (HP:0010034)1.86297554
157Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.86297554
158Widely spaced teeth (HP:0000687)1.86189406
159Abnormality of oral frenula (HP:0000190)1.85311333
160Lower limb asymmetry (HP:0100559)1.85135212
161Hyperthyroidism (HP:0000836)1.84917523
162Abnormal foot bone ossification (HP:0010675)1.84600071
163Abnormality of the 1st metacarpal (HP:0010009)1.84430393
164Flattened epiphyses (HP:0003071)1.83021169
165Amelogenesis imperfecta (HP:0000705)1.82376392
166Dysmetric saccades (HP:0000641)1.82356974
167Decreased circulating renin level (HP:0003351)1.82274267
168Aortic dissection (HP:0002647)1.81668124
169Bone cyst (HP:0012062)1.81421352
170Abnormality of calcium-phosphate metabolism (HP:0100530)1.79923592
171Large for gestational age (HP:0001520)1.79311533
172Ovoid vertebral bodies (HP:0003300)1.79052469
173Inappropriate behavior (HP:0000719)1.79045877
174Abnormality of molar morphology (HP:0011070)1.79030303
175Abnormality of molar (HP:0011077)1.79030303
176High pitched voice (HP:0001620)1.78891460
177Psychosis (HP:0000709)1.78484885
178Hyperinsulinemic hypoglycemia (HP:0000825)1.77879525
179EEG with generalized epileptiform discharges (HP:0011198)1.77547502
180Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.76844870
181Termporal pattern (HP:0011008)1.76077555
182Insidious onset (HP:0003587)1.76077555
183Abnormality of the renal cortex (HP:0011035)1.75863547
184Abnormality of the dental pulp (HP:0006479)1.75779688
185Pheochromocytoma (HP:0002666)1.73987321
186Congenital ichthyosiform erythroderma (HP:0007431)1.73606741
187Impaired vibratory sensation (HP:0002495)1.73360621
188Osteolytic defects of the phalanges of the hand (HP:0009771)1.72207753
189Osteolytic defects of the hand bones (HP:0009699)1.72207753
190Bronchomalacia (HP:0002780)1.71644826
191Distal lower limb muscle weakness (HP:0009053)1.70919038
192Resting tremor (HP:0002322)1.69657271
193Progressive neurologic deterioration (HP:0002344)1.68256898
194Narrow nasal bridge (HP:0000446)1.67604290
195Abnormal EKG (HP:0003115)1.67463770
196Spastic gait (HP:0002064)1.67386506

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.65004746
2EPHA44.43147066
3MAP3K123.69440028
4MAP3K93.47319749
5TESK13.45792976
6MAPKAPK33.23234569
7MAP3K42.95318936
8EIF2AK12.79395670
9RIPK42.69705967
10RIPK12.62651803
11TSSK62.60286480
12MAP2K72.52360141
13MINK12.35196584
14TRIB32.33431842
15LATS12.29944861
16MAP2K42.27221697
17PKN22.26149697
18SIK12.23451712
19CASK2.15279164
20RPS6KB22.03293945
21DAPK21.96031682
22EPHA31.95257121
23MARK11.92784344
24EPHA21.90870742
25LIMK11.87642560
26CDK191.87484927
27KSR21.86259498
28STK38L1.81329143
29PIK3CA1.78778672
30NTRK21.70465364
31EEF2K1.70432975
32DAPK11.69505494
33NTRK11.69349224
34MST41.67609953
35PAK61.67155034
36PNCK1.61761672
37PLK21.56799894
38GRK51.52212307
39CAMKK11.47085069
40KSR11.46591964
41SIK21.45028666
42EPHB11.43648982
43TRPM71.39902608
44CDK51.37775156
45TNIK1.36555144
46MAP3K21.34907486
47FES1.32817173
48PINK11.26542942
49JAK21.25235378
50CAMKK21.23931409
51FGFR41.22823342
52MYLK1.20621605
53MAP3K131.17410059
54CDK121.17213144
55NEK61.17104083
56PAK21.16386643
57NLK1.15707517
58MAPKAPK51.15007604
59STK31.10805134
60CAMK2A1.09090113
61PRKCI1.08362596
62CAMK11.06839995
63MAP2K61.06613127
64ARAF1.01891408
65PRKAA21.00256548
66MAPK131.00226575
67MTOR0.99780727
68PRKCG0.99554018
69PTK2B0.98849571
70FGFR20.98204178
71EIF2AK30.97836684
72STK380.96321426
73CAMK2B0.95785720
74RET0.94215661
75LMTK20.94050382
76FGFR30.93663717
77BMPR20.93465201
78MUSK0.92522780
79GRK60.89202347
80TYRO30.88262448
81PRKCH0.87146095
82OXSR10.86507239
83SGK20.85637341
84PDGFRB0.85345449
85SGK2230.85277278
86SGK4940.85277278
87PRKD30.84721270
88RAF10.82644239
89FER0.82411993
90PTK20.81914016
91DMPK0.79689989
92CDC42BPA0.78946172
93RPS6KB10.78822210
94CDK70.78397192
95CSNK1G20.77288213
96PTK60.76859042
97TNK20.76751329
98UHMK10.76481978
99LATS20.76305607
100PDK10.75102137
101JAK10.74237695
102MET0.74113859
103STK110.73968933
104NME10.70835721
105PRKD10.69979642
106MAP2K20.69923649
107HIPK20.69718118
108FGR0.69578856
109MAP3K10.68580277
110WEE10.67800024
111SGK10.67046896
112TGFBR20.66835366
113CAMK1D0.66369169
114SGK30.65526241
115MAPK150.64454765
116PAK30.64106562
117PRKCE0.63442133
118CAMK1G0.62951893
119CDK180.62499928
120PDPK10.61429692
121MAP3K60.61026932
122CDK150.60153902
123CHUK0.59398027
124TAF10.58571582
125MAPK120.57654233
126CDK140.57028707
127GRK10.55398519
128MST1R0.55041481
129ILK0.54946534
130GSK3A0.54270253
131CAMK2G0.53706622
132CAMK2D0.53669413
133PRKAA10.53161673
134CDK11A0.53013121
135ZAP700.52828991
136FRK0.52526351
137CSNK1E0.50254667
138KIT0.46745617
139PHKG10.45790400
140PHKG20.45790400
141ROCK20.45373871
142AKT30.44662246
143MAP2K10.42225774
144PRKD20.41658158
145FYN0.40567421
146SCYL20.40490004
147MARK20.40421546
148CDK30.39685790
149TTN0.39137668
150DDR20.39086512
151AKT20.38078819
152MAP3K70.37630739
153RPS6KA30.35885893
154ADRBK20.35677368
155CCNB10.35113469
156PDGFRA0.34160620
157STK390.33821024
158RPS6KA20.33494635
159DYRK1A0.33173652
160SYK0.32781634
161BRSK20.32725555
162CSNK1G30.32681947
163DAPK30.32615168
164YES10.31778398
165CSNK1A10.25802388
166ERBB20.25770636
167STK240.25616362
168CSNK1D0.25365791
169ICK0.24753426

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.74583324
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.49616646
3Synaptic vesicle cycle_Homo sapiens_hsa047212.96747077
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.69777895
5Long-term potentiation_Homo sapiens_hsa047202.67015129
6ABC transporters_Homo sapiens_hsa020102.64043029
7Circadian entrainment_Homo sapiens_hsa047132.56788028
8Amphetamine addiction_Homo sapiens_hsa050312.54464260
9GABAergic synapse_Homo sapiens_hsa047272.54268449
10Glutamatergic synapse_Homo sapiens_hsa047242.46460188
11Morphine addiction_Homo sapiens_hsa050322.42417833
12Sulfur metabolism_Homo sapiens_hsa009202.37315137
13Fatty acid elongation_Homo sapiens_hsa000622.31090957
14Sphingolipid metabolism_Homo sapiens_hsa006002.30666657
15Olfactory transduction_Homo sapiens_hsa047402.30512610
16Salivary secretion_Homo sapiens_hsa049702.24396962
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18680536
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16836731
19Dopaminergic synapse_Homo sapiens_hsa047282.15907682
20Prolactin signaling pathway_Homo sapiens_hsa049172.07745645
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03090836
22Gastric acid secretion_Homo sapiens_hsa049711.91065051
23Renin secretion_Homo sapiens_hsa049241.91002861
24Serotonergic synapse_Homo sapiens_hsa047261.82834294
25Other glycan degradation_Homo sapiens_hsa005111.80940171
26Taste transduction_Homo sapiens_hsa047421.77780877
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77166628
28Cholinergic synapse_Homo sapiens_hsa047251.77161316
29Long-term depression_Homo sapiens_hsa047301.73946952
30Cocaine addiction_Homo sapiens_hsa050301.71748227
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.71665532
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69266246
33Oxytocin signaling pathway_Homo sapiens_hsa049211.67899283
34Insulin secretion_Homo sapiens_hsa049111.67770621
35Calcium signaling pathway_Homo sapiens_hsa040201.65046820
36Collecting duct acid secretion_Homo sapiens_hsa049661.60482991
37N-Glycan biosynthesis_Homo sapiens_hsa005101.57134265
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.56088124
39GnRH signaling pathway_Homo sapiens_hsa049121.53179328
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.46726579
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45138638
42AMPK signaling pathway_Homo sapiens_hsa041521.42297723
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41629544
44Circadian rhythm_Homo sapiens_hsa047101.40843453
45Fatty acid biosynthesis_Homo sapiens_hsa000611.37998780
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37666141
47Gap junction_Homo sapiens_hsa045401.34106132
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33188401
49cAMP signaling pathway_Homo sapiens_hsa040241.27860172
50Fatty acid metabolism_Homo sapiens_hsa012121.23246183
51Butanoate metabolism_Homo sapiens_hsa006501.22591147
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20634418
53Vibrio cholerae infection_Homo sapiens_hsa051101.17787709
54Vascular smooth muscle contraction_Homo sapiens_hsa042701.17259868
55Selenocompound metabolism_Homo sapiens_hsa004501.16822580
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14883491
57Thyroid cancer_Homo sapiens_hsa052161.13682870
58Estrogen signaling pathway_Homo sapiens_hsa049151.11260851
59Endometrial cancer_Homo sapiens_hsa052131.10445606
60Insulin resistance_Homo sapiens_hsa049311.09248969
61Tight junction_Homo sapiens_hsa045301.07950657
62Melanogenesis_Homo sapiens_hsa049161.06567464
63cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05358187
64Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03339800
65Protein export_Homo sapiens_hsa030601.02261852
66Thyroid hormone synthesis_Homo sapiens_hsa049181.01250659
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01024386
68Axon guidance_Homo sapiens_hsa043601.00927636
69Propanoate metabolism_Homo sapiens_hsa006401.00565051
70Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00348474
71Lysosome_Homo sapiens_hsa041420.99331497
72Glioma_Homo sapiens_hsa052140.97966242
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96839084
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95093281
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94341643
76ErbB signaling pathway_Homo sapiens_hsa040120.93755808
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92544408
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91198526
79Insulin signaling pathway_Homo sapiens_hsa049100.90682998
80Folate biosynthesis_Homo sapiens_hsa007900.89347849
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86694398
82Dilated cardiomyopathy_Homo sapiens_hsa054140.84126637
83Tryptophan metabolism_Homo sapiens_hsa003800.82343679
84Peroxisome_Homo sapiens_hsa041460.81937918
85Prostate cancer_Homo sapiens_hsa052150.81160405
86Pancreatic secretion_Homo sapiens_hsa049720.80669546
87Cardiac muscle contraction_Homo sapiens_hsa042600.80135345
88African trypanosomiasis_Homo sapiens_hsa051430.79023502
89Type II diabetes mellitus_Homo sapiens_hsa049300.78159229
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77920755
91Glutathione metabolism_Homo sapiens_hsa004800.77395240
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77207718
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.75835854
94Dorso-ventral axis formation_Homo sapiens_hsa043200.75070398
95MAPK signaling pathway_Homo sapiens_hsa040100.74651325
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74636680
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73872085
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.73709578
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71853037
100Ras signaling pathway_Homo sapiens_hsa040140.71471641
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71058979
102VEGF signaling pathway_Homo sapiens_hsa043700.70415588
103Rap1 signaling pathway_Homo sapiens_hsa040150.70414168
104Lysine degradation_Homo sapiens_hsa003100.68771649
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67817114
106Melanoma_Homo sapiens_hsa052180.67017685
107Mineral absorption_Homo sapiens_hsa049780.66532492
108Nitrogen metabolism_Homo sapiens_hsa009100.64895324
109FoxO signaling pathway_Homo sapiens_hsa040680.64718424
110Choline metabolism in cancer_Homo sapiens_hsa052310.64455292
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59653990
112beta-Alanine metabolism_Homo sapiens_hsa004100.58605018
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.58446866
114Rheumatoid arthritis_Homo sapiens_hsa053230.57363768
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56292661
116Phototransduction_Homo sapiens_hsa047440.55956676
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55745212
118* Oocyte meiosis_Homo sapiens_hsa041140.55555491
119Alzheimers disease_Homo sapiens_hsa050100.52768011
120Arginine biosynthesis_Homo sapiens_hsa002200.52626935
121Platelet activation_Homo sapiens_hsa046110.52381458
122Histidine metabolism_Homo sapiens_hsa003400.52083402
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.48979306
124Hepatitis C_Homo sapiens_hsa051600.48653714
125Fatty acid degradation_Homo sapiens_hsa000710.48572008
126Type I diabetes mellitus_Homo sapiens_hsa049400.47889313
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47860830
128Proteoglycans in cancer_Homo sapiens_hsa052050.47656640
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47459398
130Wnt signaling pathway_Homo sapiens_hsa043100.46926622
131Vitamin B6 metabolism_Homo sapiens_hsa007500.45726544
132Inositol phosphate metabolism_Homo sapiens_hsa005620.45481228
133Glucagon signaling pathway_Homo sapiens_hsa049220.44762348
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43930443
135Phenylalanine metabolism_Homo sapiens_hsa003600.42873438
136Regulation of autophagy_Homo sapiens_hsa041400.42681583
137Alcoholism_Homo sapiens_hsa050340.42000490
138Steroid biosynthesis_Homo sapiens_hsa001000.40942867
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39511687
140Renal cell carcinoma_Homo sapiens_hsa052110.39324395
141Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38769345
142Ovarian steroidogenesis_Homo sapiens_hsa049130.36328213
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36306470
144Salmonella infection_Homo sapiens_hsa051320.36216626
145* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36026580
146Leukocyte transendothelial migration_Homo sapiens_hsa046700.35409109
147Focal adhesion_Homo sapiens_hsa045100.35109335
148Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34991416
149Amoebiasis_Homo sapiens_hsa051460.34943512
150Endocytosis_Homo sapiens_hsa041440.33558814
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33382804
152Glycosaminoglycan degradation_Homo sapiens_hsa005310.33235301
153Non-small cell lung cancer_Homo sapiens_hsa052230.31874801
154Phagosome_Homo sapiens_hsa041450.31004749
155Oxidative phosphorylation_Homo sapiens_hsa001900.30663306
156Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30101124
157mTOR signaling pathway_Homo sapiens_hsa041500.29741602
158Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29692522
159Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29417498

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