PGRMC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.84816465
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.84816465
3L-phenylalanine metabolic process (GO:0006558)6.50220921
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.50220921
5aromatic amino acid family catabolic process (GO:0009074)6.01575505
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.58893686
7bile acid biosynthetic process (GO:0006699)5.41207049
8tryptophan catabolic process (GO:0006569)5.28292061
9indole-containing compound catabolic process (GO:0042436)5.28292061
10indolalkylamine catabolic process (GO:0046218)5.28292061
11kynurenine metabolic process (GO:0070189)5.21666408
12negative regulation of fibrinolysis (GO:0051918)5.02504264
13glyoxylate metabolic process (GO:0046487)5.01449820
14high-density lipoprotein particle remodeling (GO:0034375)5.01350920
15alpha-linolenic acid metabolic process (GO:0036109)5.01096281
16tryptophan metabolic process (GO:0006568)4.95102720
17urea cycle (GO:0000050)4.87842378
18urea metabolic process (GO:0019627)4.87842378
19sulfur amino acid catabolic process (GO:0000098)4.85299572
20regulation of fibrinolysis (GO:0051917)4.83527104
21cysteine metabolic process (GO:0006534)4.75415115
22protein neddylation (GO:0045116)4.75254577
23complement activation, alternative pathway (GO:0006957)4.73769935
24regulation of protein activation cascade (GO:2000257)4.70416994
25bile acid metabolic process (GO:0008206)4.58243259
26peptidyl-glutamic acid carboxylation (GO:0017187)4.54594156
27protein carboxylation (GO:0018214)4.54594156
28nitrogen cycle metabolic process (GO:0071941)4.48242015
29cellular ketone body metabolic process (GO:0046950)4.44120457
30aromatic amino acid family metabolic process (GO:0009072)4.40878562
31regulation of complement activation (GO:0030449)4.39748316
32tyrosine metabolic process (GO:0006570)4.39149810
33reverse cholesterol transport (GO:0043691)4.36963545
34regulation of cholesterol esterification (GO:0010872)4.32292499
35protein-lipid complex remodeling (GO:0034368)4.23549833
36macromolecular complex remodeling (GO:0034367)4.23549833
37plasma lipoprotein particle remodeling (GO:0034369)4.23549833
38serine family amino acid catabolic process (GO:0009071)4.20550224
39coenzyme catabolic process (GO:0009109)4.17398907
40homocysteine metabolic process (GO:0050667)4.11568918
41glutamate metabolic process (GO:0006536)4.09115311
42cellular glucuronidation (GO:0052695)4.08456463
43acylglycerol homeostasis (GO:0055090)4.07288118
44triglyceride homeostasis (GO:0070328)4.07288118
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.06242572
46alpha-amino acid catabolic process (GO:1901606)4.06165471
47lysine catabolic process (GO:0006554)4.04700905
48lysine metabolic process (GO:0006553)4.04700905
49regulation of triglyceride catabolic process (GO:0010896)4.04417759
50benzene-containing compound metabolic process (GO:0042537)4.01086660
51negative regulation of sterol transport (GO:0032372)3.97615399
52negative regulation of cholesterol transport (GO:0032375)3.97615399
53amino-acid betaine metabolic process (GO:0006577)3.94665728
54bile acid and bile salt transport (GO:0015721)3.93397998
55phospholipid efflux (GO:0033700)3.89473980
56pyrimidine nucleobase catabolic process (GO:0006208)3.87806719
57drug catabolic process (GO:0042737)3.87016787
58indolalkylamine metabolic process (GO:0006586)3.85495633
59ketone body metabolic process (GO:1902224)3.84417752
60uronic acid metabolic process (GO:0006063)3.80873068
61glucuronate metabolic process (GO:0019585)3.80873068
62cellular amino acid catabolic process (GO:0009063)3.80533740
63imidazole-containing compound metabolic process (GO:0052803)3.80031006
64cholesterol efflux (GO:0033344)3.72666448
65plasma lipoprotein particle clearance (GO:0034381)3.69501138
66ethanol oxidation (GO:0006069)3.68834958
67cellular modified amino acid catabolic process (GO:0042219)3.68180451
68aldehyde catabolic process (GO:0046185)3.67039752
69dicarboxylic acid biosynthetic process (GO:0043650)3.64769997
70amine catabolic process (GO:0009310)3.61903662
71cellular biogenic amine catabolic process (GO:0042402)3.61903662
72arginine metabolic process (GO:0006525)3.61391428
73nucleobase catabolic process (GO:0046113)3.51067402
74response to nitrosative stress (GO:0051409)3.50111784
75exogenous drug catabolic process (GO:0042738)3.49244658
76fibrinolysis (GO:0042730)3.47806828
77low-density lipoprotein particle remodeling (GO:0034374)3.46727976
78negative regulation of lipase activity (GO:0060192)3.46047492
79flavonoid metabolic process (GO:0009812)3.43562916
80cofactor catabolic process (GO:0051187)3.43054997
81regulation of bile acid biosynthetic process (GO:0070857)3.42135787
82cytolysis (GO:0019835)3.35529589
83regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.34093468
84short-chain fatty acid metabolic process (GO:0046459)3.33683535
85organic acid catabolic process (GO:0016054)3.31141571
86carboxylic acid catabolic process (GO:0046395)3.31141571
87epoxygenase P450 pathway (GO:0019373)3.31041127
88blood coagulation, intrinsic pathway (GO:0007597)3.30431854
89complement activation, classical pathway (GO:0006958)3.29086019
90serine family amino acid metabolic process (GO:0009069)3.28000944
91opsonization (GO:0008228)3.27932371
92plasma lipoprotein particle assembly (GO:0034377)3.27564043
93drug metabolic process (GO:0017144)3.23920598
94positive regulation of lipid catabolic process (GO:0050996)3.23611570
95negative regulation of protein activation cascade (GO:2000258)3.23520207
96glycine metabolic process (GO:0006544)3.22708705
97complement activation (GO:0006956)3.22335343
98protein activation cascade (GO:0072376)3.19202951
99acetyl-CoA metabolic process (GO:0006084)3.18894624
100xenobiotic catabolic process (GO:0042178)3.18230693
101alkaloid metabolic process (GO:0009820)3.17965217
102negative regulation of norepinephrine secretion (GO:0010700)3.16306855
103phospholipid homeostasis (GO:0055091)3.11135683
104regulation of cAMP-dependent protein kinase activity (GO:2000479)3.09362266
105L-serine metabolic process (GO:0006563)3.03390428
106long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.01983252
107fatty acid elongation (GO:0030497)2.99617800
108negative regulation of catecholamine secretion (GO:0033604)2.67054456
109fatty-acyl-CoA metabolic process (GO:0035337)2.65513906
110beta-amyloid metabolic process (GO:0050435)2.62995176
111regulation of lipoprotein metabolic process (GO:0050746)2.60117122
112paraxial mesoderm development (GO:0048339)2.58385690
113polyamine biosynthetic process (GO:0006596)2.57579242
114regulation of Golgi to plasma membrane protein transport (GO:0042996)2.56286367
115regulation of integrin-mediated signaling pathway (GO:2001044)2.49726447
116long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.49640608
117linoleic acid metabolic process (GO:0043651)2.48404693
118lung-associated mesenchyme development (GO:0060484)2.45943590
119cholesterol biosynthetic process (GO:0006695)2.45680341
120regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.45540553
121midgut development (GO:0007494)2.40546011
122protein retention in ER lumen (GO:0006621)2.38759491
123fatty-acyl-CoA biosynthetic process (GO:0046949)2.34976896
124long-chain fatty acid biosynthetic process (GO:0042759)2.34195095
125positive regulation of hemostasis (GO:1900048)2.33605031
126positive regulation of blood coagulation (GO:0030194)2.33605031
127negative regulation of heart rate (GO:0010459)2.33449140
128platelet degranulation (GO:0002576)2.32822645
129serine family amino acid biosynthetic process (GO:0009070)2.31268862
130regulation of synaptic vesicle exocytosis (GO:2000300)2.30941999
131omega-hydroxylase P450 pathway (GO:0097267)2.30655288
132sterol biosynthetic process (GO:0016126)2.27766750
133negative regulation of blood coagulation (GO:0030195)2.26974580
134negative regulation of hemostasis (GO:1900047)2.26974580
135thrombin receptor signaling pathway (GO:0070493)2.25122241
136proline biosynthetic process (GO:0006561)2.24619698
137cyclooxygenase pathway (GO:0019371)2.23318925
138negative regulation of wound healing (GO:0061045)2.23215245
139anterior/posterior axis specification, embryo (GO:0008595)2.22898679
140proline metabolic process (GO:0006560)2.22172785
141protein maturation by protein folding (GO:0022417)2.22021026
142cellular response to prostaglandin stimulus (GO:0071379)2.19596816
143very long-chain fatty acid metabolic process (GO:0000038)2.18704074
144cerebellar granule cell differentiation (GO:0021707)2.18464671
145G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.17263793
146sequestering of actin monomers (GO:0042989)2.14740146
147androgen biosynthetic process (GO:0006702)2.14634086
148positive regulation of endothelial cell differentiation (GO:0045603)2.14009012
149extracellular fibril organization (GO:0043206)2.13479139
150microtubule depolymerization (GO:0007019)2.13131931
151positive regulation of coagulation (GO:0050820)2.12563665
152negative regulation of microtubule polymerization (GO:0031115)2.09611018
153ethanol metabolic process (GO:0006067)2.08906643
154polyketide metabolic process (GO:0030638)2.08673631
155doxorubicin metabolic process (GO:0044598)2.08673631
156daunorubicin metabolic process (GO:0044597)2.08673631
157mating behavior (GO:0007617)2.07720958
158positive regulation of Rho protein signal transduction (GO:0035025)2.06737765
159negative regulation of coagulation (GO:0050819)2.06388115
160maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.06220846
161positive regulation of hormone biosynthetic process (GO:0046886)2.05702882
162triglyceride catabolic process (GO:0019433)2.05127181
163establishment of integrated proviral latency (GO:0075713)2.04798006
164planar cell polarity pathway involved in neural tube closure (GO:0090179)2.00997532
165presynaptic membrane assembly (GO:0097105)2.00173043
166myelination in peripheral nervous system (GO:0022011)1.99702746

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.64683270
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.10033329
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.95331974
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.80712927
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.66251555
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.97177219
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.48046884
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.42230149
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.98967383
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.71877863
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.66266799
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.53115807
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.37072967
14SRY_22984422_ChIP-ChIP_TESTIS_Rat2.18402578
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10879144
16TAF15_26573619_Chip-Seq_HEK293_Human2.01535536
17E2F7_22180533_ChIP-Seq_HELA_Human1.85414404
18EZH2_22144423_ChIP-Seq_EOC_Human1.82106812
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82022080
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80896124
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.79101840
22GBX2_23144817_ChIP-Seq_PC3_Human1.77289105
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75021553
24TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.72525009
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67853899
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.65300462
27AR_21909140_ChIP-Seq_LNCAP_Human1.64557477
28SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.61992845
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.61342261
30SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.60686048
31TCF3_18692474_ChIP-Seq_MEFs_Mouse1.56754316
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.55388395
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54634272
34* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.48889584
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48432774
36HTT_18923047_ChIP-ChIP_STHdh_Human1.48329037
37TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.45647830
38RNF2_27304074_Chip-Seq_NSC_Mouse1.44492213
39SOX2_18555785_ChIP-Seq_MESCs_Mouse1.43032607
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40666862
41* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40187069
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39968288
43SOX2_16153702_ChIP-ChIP_HESCs_Human1.38147316
44NANOG_16153702_ChIP-ChIP_HESCs_Human1.37952673
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34699837
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.33657747
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33524665
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.33470266
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32292258
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31697988
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28254210
52REST_21632747_ChIP-Seq_MESCs_Mouse1.26000755
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25636359
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25636359
55* CLOCK_20551151_ChIP-Seq_293T_Human1.24826613
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23319311
57FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.22094528
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21904199
59TCF3_18692474_ChIP-Seq_MESCs_Mouse1.20268424
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18697349
61FOXA2_19822575_ChIP-Seq_HepG2_Human1.18464224
62NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.15764282
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.13118826
64* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.12460660
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12400100
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11101522
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10297462
68REST_18959480_ChIP-ChIP_MESCs_Mouse1.09926168
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.09513074
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08857146
71SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08760527
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07231235
73* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07145341
74IRF1_19129219_ChIP-ChIP_H3396_Human1.06369656
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04356078
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04356078
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.03272357
78KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03031627
79* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01501617
80SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01165199
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00736775
82OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00495449
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.00052540
84ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99530658
85REST_19997604_ChIP-ChIP_NEURONS_Mouse0.99037572
86EWS_26573619_Chip-Seq_HEK293_Human0.98247844
87TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96970722
88ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96883843
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96760985
90TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96614095
91TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.96564761
92P300_19829295_ChIP-Seq_ESCs_Human0.96258250
93EOMES_21245162_ChIP-Seq_HESCs_Human0.95790359
94NANOG_21062744_ChIP-ChIP_HESCs_Human0.95684506
95THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95393063
96FUS_26573619_Chip-Seq_HEK293_Human0.94985201
97AR_21572438_ChIP-Seq_LNCaP_Human0.93786335
98NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93774531
99TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.93618195
100HNF4A_19822575_ChIP-Seq_HepG2_Human0.93112855
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93104763
102* ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90942811
103BCAT_22108803_ChIP-Seq_LS180_Human0.90774656
104ISL1_27105846_Chip-Seq_CPCs_Mouse0.90601695
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90311310
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89686715
107ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87916462
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87908452
109IGF1R_20145208_ChIP-Seq_DFB_Human0.87770268
110YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86621772
111EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.86602737
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86442453
113NANOG_18692474_ChIP-Seq_MEFs_Mouse0.86209662
114JUN_21703547_ChIP-Seq_K562_Human0.85766123
115SMAD4_21799915_ChIP-Seq_A2780_Human0.84860830
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84843339
117CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.84176006
118DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83748025
119DROSHA_22980978_ChIP-Seq_HELA_Human0.82069040
120OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81582953
121NR3C1_23031785_ChIP-Seq_PC12_Mouse0.81195918
122AR_25329375_ChIP-Seq_VCAP_Human0.80481376
123ZNF274_21170338_ChIP-Seq_K562_Hela0.79063332
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78069669
125RNF2_27304074_Chip-Seq_ESCs_Mouse0.76273193
126RARB_27405468_Chip-Seq_BRAIN_Mouse0.74915819
127* SOX2_21211035_ChIP-Seq_LN229_Gbm0.74457344
128* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.74176494
129ZNF263_19887448_ChIP-Seq_K562_Human0.73936789
130* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.72006352
131SMAD4_21741376_ChIP-Seq_HESCs_Human0.71011293
132ZNF217_24962896_ChIP-Seq_MCF-7_Human0.70923965
133CDX2_19796622_ChIP-Seq_MESCs_Mouse0.70159529
134TRIM28_21343339_ChIP-Seq_HEK293_Human0.69561263
135PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.68742849
136VDR_22108803_ChIP-Seq_LS180_Human0.68593826
137RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.68113236
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.68087645
139SMAD3_21741376_ChIP-Seq_EPCs_Human0.67812625
140IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.67030077
141CBP_20019798_ChIP-Seq_JUKART_Human0.67030077
142BMI1_23680149_ChIP-Seq_NPCS_Mouse0.66712786
143TP53_18474530_ChIP-ChIP_U2OS_Human0.66365320
144RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.66213218
145NR3C1_21868756_ChIP-Seq_MCF10A_Human0.66045144
146CTCF_27219007_Chip-Seq_Bcells_Human0.65894184
147KDM2B_26808549_Chip-Seq_REH_Human0.65347675
148RXRA_24833708_ChIP-Seq_LIVER_Mouse0.65149718
149SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.65073137
150POU3F2_20337985_ChIP-ChIP_501MEL_Human0.64131926
151RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63835819
152CBX2_27304074_Chip-Seq_ESCs_Mouse0.63369623
153ESR2_21235772_ChIP-Seq_MCF-7_Human0.63034230
154AUTS2_25519132_ChIP-Seq_293T-REX_Human0.61495081
155TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.61101322
156RING1B_27294783_Chip-Seq_ESCs_Mouse0.61058466
157SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.60413488

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.64545151
2MP0005360_urolithiasis6.83847096
3MP0005085_abnormal_gallbladder_physiolo5.80243850
4MP0005365_abnormal_bile_salt5.67836972
5MP0008875_abnormal_xenobiotic_pharmacok5.13104175
6MP0003252_abnormal_bile_duct3.33998515
7MP0010329_abnormal_lipoprotein_level3.32639424
8MP0003806_abnormal_nucleotide_metabolis3.13891687
9MP0003195_calcinosis2.67374983
10MP0005083_abnormal_biliary_tract2.65434108
11MP0005332_abnormal_amino_acid2.52857884
12MP0001666_abnormal_nutrient_absorption2.26821022
13MP0005464_abnormal_platelet_physiology2.22210932
14MP0009840_abnormal_foam_cell2.20779660
15MP0004272_abnormal_basement_membrane2.18922654
16MP0003941_abnormal_skin_development2.03932549
17MP0004019_abnormal_vitamin_homeostasis1.98734098
18MP0005187_abnormal_penis_morphology1.96527137
19MP0000566_synostosis1.88780689
20MP0002118_abnormal_lipid_homeostasis1.86997300
21MP0003868_abnormal_feces_composition1.81345270
22MP0001188_hyperpigmentation1.79964157
23MP0010030_abnormal_orbit_morphology1.70975313
24MP0004270_analgesia1.65949146
25MP0000609_abnormal_liver_physiology1.65941261
26MP0008004_abnormal_stomach_pH1.63987846
27MP0008438_abnormal_cutaneous_collagen1.59977502
28MP0005623_abnormal_meninges_morphology1.56290052
29MP0003566_abnormal_cell_adhesion1.55868722
30MP0002876_abnormal_thyroid_physiology1.52928786
31MP0005319_abnormal_enzyme/_coenzyme1.47550791
32MP0008932_abnormal_embryonic_tissue1.47282812
33MP0000778_abnormal_nervous_system1.47115739
34MP0003937_abnormal_limbs/digits/tail_de1.46001891
35MP0006276_abnormal_autonomic_nervous1.45233762
36MP0002138_abnormal_hepatobiliary_system1.44884062
37MP0003191_abnormal_cellular_cholesterol1.44674446
38MP0003880_abnormal_central_pattern1.41873730
39MP0005584_abnormal_enzyme/coenzyme_acti1.39511355
40MP0001299_abnormal_eye_distance/1.38794345
41MP0001764_abnormal_homeostasis1.37997252
42MP0009697_abnormal_copulation1.36498968
43MP0002822_catalepsy1.34386349
44MP0003123_paternal_imprinting1.33576063
45MP0003329_amyloid_beta_deposits1.33448362
46MP0009672_abnormal_birth_weight1.32028235
47MP0003942_abnormal_urinary_system1.31035161
48MP0002697_abnormal_eye_size1.28356694
49MP0003121_genomic_imprinting1.27094951
50MP0000604_amyloidosis1.24340728
51MP0000049_abnormal_middle_ear1.24062672
52MP0004859_abnormal_synaptic_plasticity1.22359435
53MP0003705_abnormal_hypodermis_morpholog1.22116575
54MP0000537_abnormal_urethra_morphology1.21364923
55MP0001293_anophthalmia1.21242503
56MP0002233_abnormal_nose_morphology1.17487677
57MP0003119_abnormal_digestive_system1.17266901
58MP0000579_abnormal_nail_morphology1.15429523
59MP0005670_abnormal_white_adipose1.14531990
60MP0001984_abnormal_olfaction1.13326108
61MP0002249_abnormal_larynx_morphology1.08339722
62MP0003635_abnormal_synaptic_transmissio1.07971031
63MP0002254_reproductive_system_inflammat1.07375577
64MP0005535_abnormal_body_temperature1.06156700
65MP0002837_dystrophic_cardiac_calcinosis1.05571606
66MP0009745_abnormal_behavioral_response1.02414840
67MP0000647_abnormal_sebaceous_gland1.02346922
68MP0005084_abnormal_gallbladder_morpholo1.01808118
69MP0002063_abnormal_learning/memory/cond1.01253896
70MP0003011_delayed_dark_adaptation1.00999549
71MP0003718_maternal_effect0.99962793
72MP0000534_abnormal_ureter_morphology0.99827848
73MP0009643_abnormal_urine_homeostasis0.96939544
74MP0001501_abnormal_sleep_pattern0.94520832
75MP0002102_abnormal_ear_morphology0.94369312
76MP0003861_abnormal_nervous_system0.93615537
77MP0005503_abnormal_tendon_morphology0.93335187
78MP0005636_abnormal_mineral_homeostasis0.93291744
79MP0001849_ear_inflammation0.93073606
80MP0002909_abnormal_adrenal_gland0.90911332
81MP0002064_seizures0.90328485
82MP0005275_abnormal_skin_tensile0.90093137
83MP0005647_abnormal_sex_gland0.89591635
84MP0003315_abnormal_perineum_morphology0.89304294
85MP0001440_abnormal_grooming_behavior0.89056291
86MP0005501_abnormal_skin_physiology0.88102089
87MP0002078_abnormal_glucose_homeostasis0.87979464
88MP0008872_abnormal_physiological_respon0.87717944
89MP0002653_abnormal_ependyma_morphology0.87348733
90MP0004133_heterotaxia0.86205644
91MP0000428_abnormal_craniofacial_morphol0.84683389
92MP0005394_taste/olfaction_phenotype0.84594099
93MP0005499_abnormal_olfactory_system0.84594099
94MP0002572_abnormal_emotion/affect_behav0.84500673
95MP0001968_abnormal_touch/_nociception0.84255720
96MP0003890_abnormal_embryonic-extraembry0.82721712
97MP0004811_abnormal_neuron_physiology0.82719700
98MP0000598_abnormal_liver_morphology0.81214093
99MP0006054_spinal_hemorrhage0.80780547
100MP0006292_abnormal_olfactory_placode0.80649260
101MP0005257_abnormal_intraocular_pressure0.79502698
102MP0002092_abnormal_eye_morphology0.78955906
103MP0001905_abnormal_dopamine_level0.78866727
104MP0003186_abnormal_redox_activity0.78777014
105MP0001286_abnormal_eye_development0.78113886
106MP0009384_cardiac_valve_regurgitation0.77959516
107MP0000639_abnormal_adrenal_gland0.77770547
108MP0009703_decreased_birth_body0.77741622
109MP0005448_abnormal_energy_balance0.77668308
110MP0005376_homeostasis/metabolism_phenot0.77112322
111MP0002084_abnormal_developmental_patter0.75644198
112MP0005666_abnormal_adipose_tissue0.75539503
113MP0003283_abnormal_digestive_organ0.75269240
114MP0009642_abnormal_blood_homeostasis0.74678561
115MP0003385_abnormal_body_wall0.74535060
116MP0004957_abnormal_blastocyst_morpholog0.74187146
117MP0002938_white_spotting0.73655552
118MP0009780_abnormal_chondrocyte_physiolo0.73580127
119MP0009053_abnormal_anal_canal0.73439820
120MP0003755_abnormal_palate_morphology0.73013005
121MP0001177_atelectasis0.72743436
122MP0003690_abnormal_glial_cell0.72612649
123MP0008874_decreased_physiological_sensi0.71986938
124MP0002111_abnormal_tail_morphology0.70935322
125MP0002090_abnormal_vision0.70443584
126MP0002736_abnormal_nociception_after0.69853949
127MP0005451_abnormal_body_composition0.69620573
128MP0010368_abnormal_lymphatic_system0.69426660
129MP0005646_abnormal_pituitary_gland0.66531865
130MP0009379_abnormal_foot_pigmentation0.65981820
131MP0009764_decreased_sensitivity_to0.65856821
132MP0002069_abnormal_eating/drinking_beha0.65097925
133MP0004043_abnormal_pH_regulation0.65048831
134MP0002735_abnormal_chemical_nociception0.64915390
135MP0005334_abnormal_fat_pad0.64897758
136MP0003879_abnormal_hair_cell0.64096229
137MP0003656_abnormal_erythrocyte_physiolo0.64022571
138MP0006036_abnormal_mitochondrial_physio0.63891695
139MP0003953_abnormal_hormone_level0.63802278
140MP0001756_abnormal_urination0.63273345
141MP0000538_abnormal_urinary_bladder0.62576572
142MP0002971_abnormal_brown_adipose0.62460131
143MP0001529_abnormal_vocalization0.62092944
144MP0005220_abnormal_exocrine_pancreas0.61892862
145MP0006035_abnormal_mitochondrial_morpho0.61451632
146MP0003122_maternal_imprinting0.61129272
147MP0005248_abnormal_Harderian_gland0.60837254
148MP0005645_abnormal_hypothalamus_physiol0.60684451
149MP0004130_abnormal_muscle_cell0.59976674
150MP0002734_abnormal_mechanical_nocicepti0.59567028
151MP0009765_abnormal_xenobiotic_induced0.59235624
152MP0002272_abnormal_nervous_system0.58788835
153MP0010234_abnormal_vibrissa_follicle0.58420325
154MP0009763_increased_sensitivity_to0.58150613
155MP0005266_abnormal_metabolism0.57494230
156MP0002733_abnormal_thermal_nociception0.55797643
157MP0003638_abnormal_response/metabolism_0.54998739
158MP0003959_abnormal_lean_body0.53829227
159MP0002557_abnormal_social/conspecific_i0.53322557
160MP0005551_abnormal_eye_electrophysiolog0.52037859
161MP0004924_abnormal_behavior0.51644464
162MP0005386_behavior/neurological_phenoty0.51644464
163MP0000230_abnormal_systemic_arterial0.51471125

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.84611228
2Deep venous thrombosis (HP:0002625)6.65017694
3Intrahepatic cholestasis (HP:0001406)6.27553440
4Increased mean platelet volume (HP:0011877)6.07557150
5Hypobetalipoproteinemia (HP:0003563)6.07326800
6Prolonged partial thromboplastin time (HP:0003645)5.75095382
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.70477347
8Xanthomatosis (HP:0000991)5.50756789
9Abnormal platelet volume (HP:0011876)5.21721180
10Hyperlipoproteinemia (HP:0010980)4.95348660
11Complement deficiency (HP:0004431)4.89336832
12Hypolipoproteinemia (HP:0010981)4.26353235
13Epidermoid cyst (HP:0200040)4.07032614
14Ketosis (HP:0001946)4.04259206
15Purpura (HP:0000979)3.99311037
16Hyperglycinemia (HP:0002154)3.92060211
17Joint hemorrhage (HP:0005261)3.91189595
18Hyperammonemia (HP:0001987)3.85837564
19Hepatoblastoma (HP:0002884)3.84528725
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.83351368
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.83047028
22Abnormality of the common coagulation pathway (HP:0010990)3.73024512
23Fat malabsorption (HP:0002630)3.65605911
24Conjugated hyperbilirubinemia (HP:0002908)3.55419013
25Hypoalphalipoproteinemia (HP:0003233)3.45627969
26Prolonged bleeding time (HP:0003010)3.41850360
27Abnormality of complement system (HP:0005339)3.40560819
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.38105717
29Abnormality of aspartate family amino acid metabolism (HP:0010899)3.36738748
30Abnormality of glycine metabolism (HP:0010895)3.34474417
31Abnormality of serine family amino acid metabolism (HP:0010894)3.34474417
32Abnormality of methionine metabolism (HP:0010901)3.31081746
33Hyperglycinuria (HP:0003108)3.25022584
34Enlarged kidneys (HP:0000105)3.23854445
35Abnormality of the intrinsic pathway (HP:0010989)3.23672726
36Ketoacidosis (HP:0001993)3.19699295
37Hypercholesterolemia (HP:0003124)3.11832592
38Petechiae (HP:0000967)3.07752256
39Delayed CNS myelination (HP:0002188)3.03710193
40Neonatal hypoglycemia (HP:0001998)3.01528441
41Hypoglycemic coma (HP:0001325)3.00224680
42Abnormality of pyrimidine metabolism (HP:0004353)2.88376505
43Spontaneous abortion (HP:0005268)2.88305542
44Hyperbilirubinemia (HP:0002904)2.84155668
45Skin nodule (HP:0200036)2.76641572
46Gout (HP:0001997)2.76250697
47Polyphagia (HP:0002591)2.74869640
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.70987014
49Myokymia (HP:0002411)2.69519295
50Abnormal gallbladder physiology (HP:0012438)2.69049914
51Cholecystitis (HP:0001082)2.69049914
52Back pain (HP:0003418)2.65475446
53Steatorrhea (HP:0002570)2.61907340
54Long foot (HP:0001833)2.61877455
55Termporal pattern (HP:0011008)2.60228615
56Insidious onset (HP:0003587)2.60228615
57Abnormality of fatty-acid metabolism (HP:0004359)2.59817486
58Cortical dysplasia (HP:0002539)2.57667092
59Abnormality of nucleobase metabolism (HP:0010932)2.56979174
60Abnormality of serum amino acid levels (HP:0003112)2.55606773
61Metabolic acidosis (HP:0001942)2.47665108
62Neonatal onset (HP:0003623)2.47547824
63Abnormality of purine metabolism (HP:0004352)2.41280508
64Hepatocellular carcinoma (HP:0001402)2.40876216
65Hypochromic microcytic anemia (HP:0004840)2.39990269
66Cerebral edema (HP:0002181)2.38707420
67Lethargy (HP:0001254)2.37115601
68Brushfield spots (HP:0001088)2.36799375
69Diastasis recti (HP:0001540)2.35838343
70Sensorimotor neuropathy (HP:0007141)2.34477364
71Abnormal gallbladder morphology (HP:0012437)2.33849673
72Irritability (HP:0000737)2.32099008
73Status epilepticus (HP:0002133)2.31551493
74Coronal craniosynostosis (HP:0004440)2.31474513
75Acanthocytosis (HP:0001927)2.31080588
76Hypoglycemic seizures (HP:0002173)2.28313347
77Cholelithiasis (HP:0001081)2.26845923
78Premature rupture of membranes (HP:0001788)2.24517422
79Hyperventilation (HP:0002883)2.22643359
80Vascular calcification (HP:0004934)2.18974609
81Mitral stenosis (HP:0001718)2.18032479
82Gingival bleeding (HP:0000225)2.16988392
83Amyloidosis (HP:0011034)2.15546195
84Limb dystonia (HP:0002451)2.14112987
85Spastic diplegia (HP:0001264)2.13866234
86Neoplasm of the adrenal cortex (HP:0100641)2.12763580
87Systemic lupus erythematosus (HP:0002725)2.09178897
88Impaired vibration sensation in the lower limbs (HP:0002166)2.08429481
89Malnutrition (HP:0004395)2.03495466
90Abnormal pancreas size (HP:0012094)2.03286589
91Impaired platelet aggregation (HP:0003540)2.00233305
92Abnormal platelet function (HP:0011869)2.00233305
93Turricephaly (HP:0000262)1.96192547
94Cardiovascular calcification (HP:0011915)1.94507507
95Glomerulonephritis (HP:0000099)1.93929339
96Late onset (HP:0003584)1.93746716
97Craniofacial dystonia (HP:0012179)1.93524244
98Abnormality of the gallbladder (HP:0005264)1.93470739
99Torticollis (HP:0000473)1.92552888
100Vomiting (HP:0002013)1.92389580
101Myocardial infarction (HP:0001658)1.90902492
102Dicarboxylic aciduria (HP:0003215)1.87049688
103Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87049688
104Cerebral inclusion bodies (HP:0100314)1.84662786
105Neoplasm of the adrenal gland (HP:0100631)1.84270244
106Focal dystonia (HP:0004373)1.84073644
107Hydroxyprolinuria (HP:0003080)1.84053000
108Abnormality of proline metabolism (HP:0010907)1.84053000
109Neurofibrillary tangles (HP:0002185)1.82327029
110Protrusio acetabuli (HP:0003179)1.80605582
111Upper limb muscle weakness (HP:0003484)1.80372222
112Menorrhagia (HP:0000132)1.79969007
113Epistaxis (HP:0000421)1.79961970
114Delayed myelination (HP:0012448)1.78650334
115Poor suck (HP:0002033)1.78528690
116Split foot (HP:0001839)1.78181273
117Aplasia involving bones of the extremities (HP:0009825)1.77804205
118Aplasia involving bones of the upper limbs (HP:0009823)1.77804205
119Aplasia of the phalanges of the hand (HP:0009802)1.77804205
120Alkalosis (HP:0001948)1.77330897
121Opisthotonus (HP:0002179)1.77140642
122Pancreatitis (HP:0001733)1.76971949
123Rickets (HP:0002748)1.76069521
124Generalized hypotonia (HP:0001290)1.73667993
125Confusion (HP:0001289)1.72847249
126Abnormality of vitamin metabolism (HP:0100508)1.72431710
127Osteomalacia (HP:0002749)1.71827726
128Abnormality of the corticospinal tract (HP:0002492)1.70609604
129Hypophosphatemic rickets (HP:0004912)1.68773362
130Abnormality of dentin (HP:0010299)1.68729038
131Urinary urgency (HP:0000012)1.67838509
132Increased purine levels (HP:0004368)1.67439138
133Myelomeningocele (HP:0002475)1.67401136
134Bifid scrotum (HP:0000048)1.67193782
135Choanal stenosis (HP:0000452)1.66467053
136Abnormality of the labia minora (HP:0012880)1.64982520
137Abnormal eating behavior (HP:0100738)1.64065807
138Abnormality of the Achilles tendon (HP:0005109)1.59810816
139Impaired pain sensation (HP:0007328)1.56034793
140Abnormality of pain sensation (HP:0010832)1.56034793
141Partial duplication of thumb phalanx (HP:0009944)1.54845365
142Ankle contracture (HP:0006466)1.54669972
143Degeneration of the lateral corticospinal tracts (HP:0002314)1.54542089
144Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.54542089
145Sleep apnea (HP:0010535)1.53903113
146Partial duplication of the phalanx of hand (HP:0009999)1.53349106
147Poikilocytosis (HP:0004447)1.53129934
148Failure to thrive in infancy (HP:0001531)1.52463020
149Papillary thyroid carcinoma (HP:0002895)1.51382777
150Decreased muscle mass (HP:0003199)1.51178431
151Abnormality of the diencephalon (HP:0010662)1.49750849
152Abnormal delivery (HP:0001787)1.48020794
153Bifid tongue (HP:0010297)1.47631598
154Humeroradial synostosis (HP:0003041)1.46581317
155Synostosis involving the elbow (HP:0003938)1.46581317
156Broad metatarsal (HP:0001783)1.45051325
157Spastic gait (HP:0002064)1.43821873
158Morphological abnormality of the pyramidal tract (HP:0002062)1.43039357
159Dyschromatopsia (HP:0007641)1.42918303
160Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.42354367
161Hypoventilation (HP:0002791)1.41369394
162Labial hypoplasia (HP:0000066)1.39879451
163Conjunctival telangiectasia (HP:0000524)1.39461858
164Abnormal pupillary function (HP:0007686)1.39290262
165Absent eyelashes (HP:0000561)1.39098228
166Drooling (HP:0002307)1.39058208

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.83896917
2MAP2K42.97419557
3EPHA42.86079997
4MARK12.66060815
5STK162.64079457
6MAP3K122.59132296
7MAP3K92.55813431
8SIK12.49862794
9FGFR42.42374423
10NTRK32.42182116
11DAPK22.33214270
12MAP3K42.18522157
13BMX2.16014589
14EIF2AK12.14620874
15DYRK22.08785814
16MINK12.05434085
17INSRR1.90936866
18ERBB41.86723232
19PRKG21.86220656
20ERN11.84331562
21MST41.82384053
22TRIM281.77085582
23MAP2K71.71934706
24TNIK1.69621671
25BRSK21.67453387
26CDC71.65642124
27CAMK2G1.54293114
28KSR11.51662188
29DYRK31.51235483
30FRK1.47023618
31CAMK2B1.46506587
32WEE11.46346370
33TTK1.42164818
34ARAF1.40644055
35TESK11.37344708
36NTRK21.36218577
37KSR21.35294538
38SIK21.32897988
39CDK141.31683102
40RIPK11.31631848
41SRPK11.30112420
42PLK31.24771430
43FGFR21.23711565
44MST1R1.22501399
45DAPK11.21946514
46PAK31.21362979
47WNK31.21327489
48SIK31.20821348
49PIK3CG1.19842596
50MAP3K21.19615047
51BRSK11.15944495
52CDK181.14317854
53MAPK151.14063176
54PRKCG1.13962341
55LATS21.13720194
56PBK1.13182534
57CASK1.13063997
58TAOK31.11532054
59NTRK11.10767304
60BUB11.10633996
61CDK151.10260090
62LIMK11.07949079
63MYLK1.07060106
64FER1.06874455
65ILK1.06314976
66GRK51.05847810
67MAP2K11.04237953
68CAMKK21.03963784
69CAMK2A1.03519384
70CDK11A0.99495390
71PAK60.99401544
72CAMK2D0.99207854
73CAMKK10.99058114
74PDGFRA0.98106626
75CSNK1A1L0.95858868
76PRKCZ0.94990502
77CAMK1D0.93208306
78MAP3K130.92108737
79PAK40.88494646
80CAMK1G0.88149565
81MKNK10.87427973
82CSNK1G20.85714504
83PAK10.83379240
84STK30.82107801
85DDR20.80152966
86AURKA0.79568823
87TSSK60.77729068
88NEK10.77472301
89ABL20.77327644
90DAPK30.77305460
91RET0.74769309
92PINK10.72179095
93BCR0.71837304
94PRKACG0.71708143
95CDK50.70712369
96PLK10.69159505
97MAPK40.68551825
98SGK2230.68528697
99SGK4940.68528697
100GRK60.63347725
101PRKCE0.60905670
102PHKG10.60814794
103PHKG20.60814794
104LATS10.59577384
105CSNK1G30.59042550
106MET0.58868008
107EPHA30.58117203
108CDK190.55169304
109RPS6KA40.54793502
110EPHB20.54646860
111ERBB20.54598095
112PAK20.53304062
113DYRK1A0.53109047
114PTK20.52686056
115SGK20.52584920
116CSNK1G10.52284692
117MAPK110.51345565
118UHMK10.50507799
119* CSNK1E0.49058149
120STK240.48990268
121TYRO30.48232515
122DMPK0.47838104
123MAP2K60.47272255
124MKNK20.46895522
125MAP3K60.46673571
126EPHA20.46563895
127ERBB30.45839462
128LMTK20.45744217
129MAP3K10.45413086
130MAP3K50.45061436
131BRAF0.44751227
132PTK2B0.43337412
133PLK20.42784844
134AKT20.42768507
135OXSR10.42715201
136STK38L0.42314376
137TAOK20.42072690
138PRKCA0.41550368
139PRKACA0.41094579
140JAK20.40540059
141CHEK20.40317850
142MAPK130.40264638
143ADRBK10.40227448
144PTK60.39715995
145CAMK40.37757026
146CAMK10.37140739
147MAP3K70.36671356
148DYRK1B0.36265655
149WNK40.36252752
150PDPK10.35442598
151PNCK0.34569854
152MAPK120.34046262

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.29569351
2Nitrogen metabolism_Homo sapiens_hsa009103.33368903
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.29563320
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.29292244
5Arginine biosynthesis_Homo sapiens_hsa002202.89450487
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.63955765
7Tryptophan metabolism_Homo sapiens_hsa003802.51994657
8Complement and coagulation cascades_Homo sapiens_hsa046102.45786235
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.37421136
10Butanoate metabolism_Homo sapiens_hsa006502.36672319
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.24437398
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.17689280
13Fatty acid degradation_Homo sapiens_hsa000712.17389101
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15620181
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.06185369
16Chemical carcinogenesis_Homo sapiens_hsa052042.02870686
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.01656996
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.91367415
19Peroxisome_Homo sapiens_hsa041461.89189432
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85007996
21Propanoate metabolism_Homo sapiens_hsa006401.76294733
22Histidine metabolism_Homo sapiens_hsa003401.73679795
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70846241
24PPAR signaling pathway_Homo sapiens_hsa033201.69988730
25Bile secretion_Homo sapiens_hsa049761.64505012
26Fatty acid metabolism_Homo sapiens_hsa012121.60569841
27Retinol metabolism_Homo sapiens_hsa008301.58002258
28Phenylalanine metabolism_Homo sapiens_hsa003601.57740966
29beta-Alanine metabolism_Homo sapiens_hsa004101.56035722
30Caffeine metabolism_Homo sapiens_hsa002321.55231383
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55048171
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.50984071
33Sulfur metabolism_Homo sapiens_hsa009201.43494313
34Tyrosine metabolism_Homo sapiens_hsa003501.43305809
35Pyruvate metabolism_Homo sapiens_hsa006201.41399201
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39866593
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.39441714
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30890178
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29823632
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25607982
41Starch and sucrose metabolism_Homo sapiens_hsa005001.25556995
42ECM-receptor interaction_Homo sapiens_hsa045121.25211482
43Staphylococcus aureus infection_Homo sapiens_hsa051501.22576884
44Selenocompound metabolism_Homo sapiens_hsa004501.19623881
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.10734916
46Gap junction_Homo sapiens_hsa045401.09147334
47Fatty acid elongation_Homo sapiens_hsa000621.07663392
48Fat digestion and absorption_Homo sapiens_hsa049751.05895534
49Mismatch repair_Homo sapiens_hsa034301.05665790
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.03557596
51ABC transporters_Homo sapiens_hsa020100.98043452
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.97831753
53Biosynthesis of amino acids_Homo sapiens_hsa012300.95422373
54Arachidonic acid metabolism_Homo sapiens_hsa005900.92998979
55Carbon metabolism_Homo sapiens_hsa012000.91965972
56Renin-angiotensin system_Homo sapiens_hsa046140.91102817
57Steroid biosynthesis_Homo sapiens_hsa001000.81889447
58Folate biosynthesis_Homo sapiens_hsa007900.78318262
59Nicotine addiction_Homo sapiens_hsa050330.76860423
60Arginine and proline metabolism_Homo sapiens_hsa003300.74943956
61Hippo signaling pathway_Homo sapiens_hsa043900.73915785
62Alcoholism_Homo sapiens_hsa050340.73845390
63Sulfur relay system_Homo sapiens_hsa041220.70089416
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68139056
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67766986
66Basal cell carcinoma_Homo sapiens_hsa052170.67509546
67Lysine degradation_Homo sapiens_hsa003100.66560282
68Glycerolipid metabolism_Homo sapiens_hsa005610.65369322
69Linoleic acid metabolism_Homo sapiens_hsa005910.64329658
70Vitamin digestion and absorption_Homo sapiens_hsa049770.63720402
71Glutathione metabolism_Homo sapiens_hsa004800.63269762
72Prion diseases_Homo sapiens_hsa050200.63021201
73Vibrio cholerae infection_Homo sapiens_hsa051100.62234422
74Adherens junction_Homo sapiens_hsa045200.62105190
75Hedgehog signaling pathway_Homo sapiens_hsa043400.61868517
76Platelet activation_Homo sapiens_hsa046110.58276812
77GABAergic synapse_Homo sapiens_hsa047270.57039432
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56649745
79Tight junction_Homo sapiens_hsa045300.55347077
80Vitamin B6 metabolism_Homo sapiens_hsa007500.53737606
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53602504
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53483149
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51679148
84Synaptic vesicle cycle_Homo sapiens_hsa047210.51623286
85Axon guidance_Homo sapiens_hsa043600.49838989
86Parkinsons disease_Homo sapiens_hsa050120.46356498
87DNA replication_Homo sapiens_hsa030300.46211233
88Cell cycle_Homo sapiens_hsa041100.44555286
89Protein digestion and absorption_Homo sapiens_hsa049740.42184496
90Fatty acid biosynthesis_Homo sapiens_hsa000610.41951780
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41749223
92Metabolic pathways_Homo sapiens_hsa011000.40472833
93Wnt signaling pathway_Homo sapiens_hsa043100.39897397
94One carbon pool by folate_Homo sapiens_hsa006700.39680076
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36589513
96Glucagon signaling pathway_Homo sapiens_hsa049220.36145997
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32605685
98Collecting duct acid secretion_Homo sapiens_hsa049660.31437111
99Insulin secretion_Homo sapiens_hsa049110.28700482
100Thyroid hormone synthesis_Homo sapiens_hsa049180.28036971
101African trypanosomiasis_Homo sapiens_hsa051430.27586245
102Renin secretion_Homo sapiens_hsa049240.24766801
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24669848
104Oxidative phosphorylation_Homo sapiens_hsa001900.22711766
105Glutamatergic synapse_Homo sapiens_hsa047240.22263715
106Circadian entrainment_Homo sapiens_hsa047130.20795943
107Cocaine addiction_Homo sapiens_hsa050300.19287496
108Galactose metabolism_Homo sapiens_hsa000520.19230362
109Pentose phosphate pathway_Homo sapiens_hsa000300.18992759
110Dopaminergic synapse_Homo sapiens_hsa047280.18385790
111Amphetamine addiction_Homo sapiens_hsa050310.18091941
112Salivary secretion_Homo sapiens_hsa049700.17919724
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.17599327
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.17408230
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14969532
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12882106
117Morphine addiction_Homo sapiens_hsa050320.12290047
118Gastric acid secretion_Homo sapiens_hsa049710.12074036
119Fructose and mannose metabolism_Homo sapiens_hsa000510.11986712
120Taste transduction_Homo sapiens_hsa047420.11314347
121Alzheimers disease_Homo sapiens_hsa050100.10209112
122Serotonergic synapse_Homo sapiens_hsa047260.09359160
123Long-term potentiation_Homo sapiens_hsa047200.08861916
124Insulin resistance_Homo sapiens_hsa049310.07955187

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