PGRMC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine metabolic process (GO:0006558)4.71229578
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.71229578
3L-phenylalanine catabolic process (GO:0006559)4.68475179
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.68475179
5alpha-linolenic acid metabolic process (GO:0036109)4.50866182
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.48061975
7sulfur amino acid catabolic process (GO:0000098)4.24821388
8regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.90659407
9positive regulation of fatty acid beta-oxidation (GO:0032000)3.88482183
10protein carboxylation (GO:0018214)3.82263342
11peptidyl-glutamic acid carboxylation (GO:0017187)3.82263342
12low-density lipoprotein particle clearance (GO:0034383)3.70165901
13paraxial mesoderm development (GO:0048339)3.67548450
14cysteine metabolic process (GO:0006534)3.61652115
15regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.61242593
16plasma lipoprotein particle clearance (GO:0034381)3.59937302
17aromatic amino acid family catabolic process (GO:0009074)3.58956762
18negative regulation of fibrinolysis (GO:0051918)3.56304873
19high-density lipoprotein particle remodeling (GO:0034375)3.54823958
20acylglycerol catabolic process (GO:0046464)3.54123661
21neutral lipid catabolic process (GO:0046461)3.54123661
22regulation of triglyceride catabolic process (GO:0010896)3.49232248
23cellular modified amino acid catabolic process (GO:0042219)3.49059353
24regulation of cholesterol homeostasis (GO:2000188)3.48596213
25triglyceride catabolic process (GO:0019433)3.47790603
26positive regulation of lipid catabolic process (GO:0050996)3.47121268
27triglyceride homeostasis (GO:0070328)3.45372398
28acylglycerol homeostasis (GO:0055090)3.45372398
29lysine metabolic process (GO:0006553)3.41828486
30lysine catabolic process (GO:0006554)3.41828486
31positive regulation of fatty acid oxidation (GO:0046321)3.40086259
32glutamate metabolic process (GO:0006536)3.34088815
33regulation of fatty acid beta-oxidation (GO:0031998)3.33865043
34coenzyme catabolic process (GO:0009109)3.28904698
35bile acid biosynthetic process (GO:0006699)3.24917600
364-hydroxyproline metabolic process (GO:0019471)3.24825466
37urea cycle (GO:0000050)3.22620967
38urea metabolic process (GO:0019627)3.22620967
39epoxygenase P450 pathway (GO:0019373)3.21900656
40regulation of fibrinolysis (GO:0051917)3.16325251
41glyoxylate metabolic process (GO:0046487)3.12701578
42short-chain fatty acid metabolic process (GO:0046459)3.11614191
43collagen fibril organization (GO:0030199)3.11481614
44reverse cholesterol transport (GO:0043691)3.10604314
45desmosome organization (GO:0002934)3.09556416
46sequestering of extracellular ligand from receptor (GO:0035581)3.08852162
47complement activation, alternative pathway (GO:0006957)3.08537632
48phospholipid efflux (GO:0033700)3.08275204
49protein-lipid complex remodeling (GO:0034368)3.06929812
50macromolecular complex remodeling (GO:0034367)3.06929812
51plasma lipoprotein particle remodeling (GO:0034369)3.06929812
52serine family amino acid catabolic process (GO:0009071)3.05121854
53kidney mesenchyme development (GO:0072074)3.04724349
54chondrocyte proliferation (GO:0035988)3.04703676
55kynurenine metabolic process (GO:0070189)3.03602476
56valine metabolic process (GO:0006573)3.03493887
57negative regulation of hormone metabolic process (GO:0032351)3.02424205
58dicarboxylic acid biosynthetic process (GO:0043650)3.01242955
59homocysteine metabolic process (GO:0050667)3.01208362
60acetyl-CoA metabolic process (GO:0006084)3.00664310
61tyrosine metabolic process (GO:0006570)3.00379055
62amino-acid betaine metabolic process (GO:0006577)2.99603180
63negative regulation of lipase activity (GO:0060192)2.98014439
64cellular ketone body metabolic process (GO:0046950)2.97977177
65metanephric mesenchyme development (GO:0072075)2.97527428
66biotin metabolic process (GO:0006768)2.96746798
67fatty-acyl-CoA biosynthetic process (GO:0046949)2.96735736
68regulation of cholesterol esterification (GO:0010872)2.94287307
69positive regulation of fatty acid metabolic process (GO:0045923)2.92886051
70negative regulation of cholesterol transport (GO:0032375)2.92318231
71negative regulation of sterol transport (GO:0032372)2.92318231
72nitrogen cycle metabolic process (GO:0071941)2.91219538
73cellular amino acid catabolic process (GO:0009063)2.90466650
74bile acid metabolic process (GO:0008206)2.90162487
75skin morphogenesis (GO:0043589)2.89791011
76fatty acid beta-oxidation (GO:0006635)2.88081034
77fatty acid oxidation (GO:0019395)2.87569765
78regulation of type B pancreatic cell apoptotic process (GO:2000674)2.87528069
79negative regulation of hormone biosynthetic process (GO:0032353)2.87476146
80alpha-amino acid catabolic process (GO:1901606)2.86816237
81intestinal absorption (GO:0050892)2.86794678
82fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.85898458
83regulation of protein activation cascade (GO:2000257)2.83853584
84positive regulation of triglyceride metabolic process (GO:0090208)2.83351418
85lipid oxidation (GO:0034440)2.80208198
86negative regulation of fatty acid biosynthetic process (GO:0045717)2.79877468
87cellular response to vitamin (GO:0071295)2.78804371
88thioester biosynthetic process (GO:0035384)2.78248832
89acyl-CoA biosynthetic process (GO:0071616)2.78248832
90triglyceride metabolic process (GO:0006641)2.77547576
91endodermal cell differentiation (GO:0035987)2.76447119
92long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.75796655
93protein localization to endosome (GO:0036010)2.75450928
94aspartate family amino acid catabolic process (GO:0009068)2.73978480
95fatty acid catabolic process (GO:0009062)2.73926286
96hormone catabolic process (GO:0042447)2.70039524
97regulation of sequestering of triglyceride (GO:0010889)2.69546726
98positive regulation of glycolytic process (GO:0045821)2.69192047
99monocarboxylic acid catabolic process (GO:0072329)2.68457314
100aromatic amino acid family metabolic process (GO:0009072)2.67251317
101regulation of complement activation (GO:0030449)2.67042783
102protein heterotrimerization (GO:0070208)2.66748217
103acylglycerol metabolic process (GO:0006639)2.66433096
104regulation of triglyceride metabolic process (GO:0090207)2.65509362
105cholesterol efflux (GO:0033344)2.65327241
106fatty-acyl-CoA metabolic process (GO:0035337)2.64888406
107regulation of lipid catabolic process (GO:0050994)2.64476888
108neutral lipid metabolic process (GO:0006638)2.63871714
109drug catabolic process (GO:0042737)2.63548790
110planar cell polarity pathway involved in neural tube closure (GO:0090179)2.63399195
111linoleic acid metabolic process (GO:0043651)2.63395605
112ethanol oxidation (GO:0006069)2.63114449
113fatty acid transmembrane transport (GO:1902001)2.62116646
114fatty acid homeostasis (GO:0055089)2.62040564
115regulation of fatty acid oxidation (GO:0046320)2.60448787
116regulation of plasminogen activation (GO:0010755)2.59635947
117glycerolipid catabolic process (GO:0046503)2.59179094
1182-oxoglutarate metabolic process (GO:0006103)2.58501953
119carboxylic acid catabolic process (GO:0046395)2.58491764
120organic acid catabolic process (GO:0016054)2.58491764
121maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.57090029
122COPII vesicle coating (GO:0048208)2.56495421
123gap junction assembly (GO:0016264)2.54489352
124adhesion of symbiont to host cell (GO:0044650)2.53699002
125virion attachment to host cell (GO:0019062)2.53699002
126non-canonical Wnt signaling pathway (GO:0035567)2.52520484
127protein retention in ER lumen (GO:0006621)2.51411271
128negative regulation of gluconeogenesis (GO:0045721)2.50740841
129transcytosis (GO:0045056)2.48391827
130adhesion of symbiont to host (GO:0044406)2.47890225
131regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.44993125
132peptidyl-proline hydroxylation (GO:0019511)2.43815747
133regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.40945056
134negative regulation of glycogen metabolic process (GO:0070874)2.39534155
135bundle of His cell to Purkinje myocyte communication (GO:0086069)2.38313141
136regulation of transforming growth factor beta1 production (GO:0032908)2.37802693
137endothelial cell morphogenesis (GO:0001886)2.35331401
138negative regulation of fatty acid transport (GO:2000192)2.34196925
139smooth muscle tissue development (GO:0048745)2.33270983
140regulation of glucocorticoid metabolic process (GO:0031943)2.32697305
141anterior/posterior axis specification, embryo (GO:0008595)2.32483297
142Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.31172425
143regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.30927999
144cell migration involved in sprouting angiogenesis (GO:0002042)2.30881322
145regulation of extracellular matrix disassembly (GO:0010715)2.28626521
146bone trabecula formation (GO:0060346)2.27506856
147convergent extension (GO:0060026)2.27102234
148negative regulation of cardiac muscle tissue growth (GO:0055022)2.26164850
149negative regulation of heart growth (GO:0061117)2.26164850
150type B pancreatic cell proliferation (GO:0044342)2.24808509
151cellular response to vitamin D (GO:0071305)2.22847464
152cochlea morphogenesis (GO:0090103)2.21808986
153ethanol metabolic process (GO:0006067)2.21463654
154regulation of establishment of planar polarity (GO:0090175)2.21369894
155G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.19116722
156notochord development (GO:0030903)2.18108017
157primary alcohol metabolic process (GO:0034308)2.18005296
158regulation of lipoprotein metabolic process (GO:0050746)2.17921763
159protein hydroxylation (GO:0018126)2.16463738
160epithelial cell-cell adhesion (GO:0090136)2.16112710
161polarized epithelial cell differentiation (GO:0030859)2.15361271
162angiotensin maturation (GO:0002003)2.13426972
163negative regulation of cardiac muscle tissue development (GO:0055026)2.13146166
164basement membrane organization (GO:0071711)2.12022844
165inner ear receptor cell development (GO:0060119)2.09527394
166establishment of tissue polarity (GO:0007164)2.09159103
167establishment of planar polarity (GO:0001736)2.09159103
168retinol metabolic process (GO:0042572)2.08902690
169cell differentiation involved in metanephros development (GO:0072202)2.08438026
170intestinal cholesterol absorption (GO:0030299)2.08328765
171cell adhesion mediated by integrin (GO:0033627)2.06882634
172cellular response to nutrient (GO:0031670)2.06265138
173mesenchymal-epithelial cell signaling (GO:0060638)2.05767363
174hemidesmosome assembly (GO:0031581)2.05763764
175outer ear morphogenesis (GO:0042473)2.04528852
176embryonic retina morphogenesis in camera-type eye (GO:0060059)2.04264039
177ER overload response (GO:0006983)2.04181490
178cellular response to hepatocyte growth factor stimulus (GO:0035729)2.03722015
179response to hepatocyte growth factor (GO:0035728)2.03722015
180middle ear morphogenesis (GO:0042474)2.01601029
181positive regulation of osteoblast proliferation (GO:0033690)2.01394537
182trabecula formation (GO:0060343)2.00291122
183mesenchymal cell differentiation involved in renal system development (GO:2001012)1.98811270
184mesenchymal cell differentiation involved in kidney development (GO:0072161)1.98811270
185very-low-density lipoprotein particle assembly (GO:0034379)1.98715249
186branching involved in salivary gland morphogenesis (GO:0060445)1.97970068
187cellular glucuronidation (GO:0052695)1.96991291
188NADH metabolic process (GO:0006734)1.96702825
189chondrocyte development (GO:0002063)1.96167969
190endocardial cushion development (GO:0003197)1.95881309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.04890127
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.47958812
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.52120584
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.96348048
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.87893175
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.83889651
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.77184712
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.66282777
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.58712986
10CLOCK_20551151_ChIP-Seq_293T_Human2.49326519
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.46539202
12ZNF263_19887448_ChIP-Seq_K562_Human2.25378000
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.03041402
14RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81602164
15EGR1_23403033_ChIP-Seq_LIVER_Mouse1.75349349
16ESR2_21235772_ChIP-Seq_MCF-7_Human1.74216984
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71226486
18AR_21909140_ChIP-Seq_LNCAP_Human1.68295421
19* CJUN_26792858_Chip-Seq_BT549_Human1.66125556
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.58269466
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.53858906
22ERG_21242973_ChIP-ChIP_JURKAT_Human1.51476976
23FOXO3_23340844_ChIP-Seq_DLD1_Human1.50827906
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47886716
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41673570
26* BRD4_25478319_ChIP-Seq_HGPS_Human1.41381592
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39395114
28* TP53_18474530_ChIP-ChIP_U2OS_Human1.37184827
29NFIB_24661679_ChIP-Seq_LUNG_Mouse1.35558931
30KDM2B_26808549_Chip-Seq_K562_Human1.34992388
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34727313
32FOXA2_19822575_ChIP-Seq_HepG2_Human1.33707516
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33298033
34LXR_22292898_ChIP-Seq_THP-1_Human1.32686478
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31658983
36* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29814419
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28801800
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28478940
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28208536
40RACK7_27058665_Chip-Seq_MCF-7_Human1.26613956
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23997865
42P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23844787
43SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23427209
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22600176
45TCF3_18692474_ChIP-Seq_MEFs_Mouse1.20142057
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19596781
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16210115
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15310553
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15182977
50* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14571390
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13967380
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13817135
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13052871
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13052871
55TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12808190
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12286170
57TCF4_18268006_ChIP-ChIP_LS174T_Human1.11403283
58CREB1_26743006_Chip-Seq_LNCaP_Human1.10822727
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09121078
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08746810
61* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08573262
62MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08149085
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06641235
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06310168
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05933798
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05293403
67SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04901415
68ATF3_27146783_Chip-Seq_COLON_Human1.04893328
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04323433
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03785069
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.03575329
72* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03489846
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03125348
74* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02608528
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02223968
76ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02101004
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.01825222
78* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00276374
79ESR1_20079471_ChIP-ChIP_T-47D_Human0.99572746
80CDX2_20551321_ChIP-Seq_CACO-2_Human0.99501064
81RING1B_27294783_Chip-Seq_NPCs_Mouse0.97554271
82* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97488587
83TBX20_22328084_ChIP-Seq_HEART_Mouse0.97446926
84TBX20_22080862_ChIP-Seq_HEART_Mouse0.97446926
85ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97430080
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96805640
87FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96428846
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95693799
89ISL1_27105846_Chip-Seq_CPCs_Mouse0.95380987
90NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95211516
91EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94869082
92RUNX1_27514584_Chip-Seq_MCF-7_Human0.93952670
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93916972
94NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93916972
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93845191
96WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93757116
97SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93611218
98* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93106074
99EP300_21415370_ChIP-Seq_HL-1_Mouse0.92819035
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92406808
101KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92205408
102TBX3_20139965_ChIP-Seq_MESCs_Mouse0.92143336
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91176417
104SALL1_21062744_ChIP-ChIP_HESCs_Human0.91126250
105TBX3_20139965_ChIP-Seq_ESCs_Mouse0.90766087
106TP53_20018659_ChIP-ChIP_R1E_Mouse0.90633522
107PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90415107
108DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90174172
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89356087
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88565853
111FOXA1_25552417_ChIP-Seq_VCAP_Human0.88019647
112RARB_27405468_Chip-Seq_BRAIN_Mouse0.87657350
113RING1B_27294783_Chip-Seq_ESCs_Mouse0.87332917
114RNF2_27304074_Chip-Seq_ESCs_Mouse0.87249097
115* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.86510411
116ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85691183
117SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85205750
118SA1_22415368_ChIP-Seq_MEFs_Mouse0.85165283
119SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.85105994
120BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85091833
121* HNF4A_19822575_ChIP-Seq_HepG2_Human0.84869388
122JARID2_20075857_ChIP-Seq_MESCs_Mouse0.84312944
123* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84249563
124CBX2_27304074_Chip-Seq_ESCs_Mouse0.83985189
125PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.82227956
126MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.81524552
127AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81351005
128CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81253945
129GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.80358822
130CTCF_27219007_Chip-Seq_Bcells_Human0.80311716
131ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80109284
132TP63_22573176_ChIP-Seq_HFKS_Human0.79055324
133RXR_22108803_ChIP-Seq_LS180_Human0.79013746
134* SOX2_20726797_ChIP-Seq_SW620_Human0.78541087
135WT1_19549856_ChIP-ChIP_CCG9911_Human0.78450879
136GATA6_25053715_ChIP-Seq_YYC3_Human0.78381147
137NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.77264498
138* KDM2B_26808549_Chip-Seq_DND41_Human0.76567167
139GATA3_24758297_ChIP-Seq_MCF-7_Human0.75810252
140SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.75592919
141GATA4_25053715_ChIP-Seq_YYC3_Human0.74999919

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.58535639
2MP0005360_urolithiasis4.91183335
3MP0005085_abnormal_gallbladder_physiolo3.74165375
4MP0005365_abnormal_bile_salt3.62615089
5MP0003705_abnormal_hypodermis_morpholog3.53836062
6MP0008875_abnormal_xenobiotic_pharmacok2.96284784
7MP0009379_abnormal_foot_pigmentation2.88518703
8MP0005503_abnormal_tendon_morphology2.81441444
9MP0003941_abnormal_skin_development2.70483130
10MP0010329_abnormal_lipoprotein_level2.67438224
11MP0003252_abnormal_bile_duct2.57309034
12MP0005257_abnormal_intraocular_pressure2.48134672
13MP0004185_abnormal_adipocyte_glucose2.46534368
14MP0002796_impaired_skin_barrier2.38355609
15MP0009780_abnormal_chondrocyte_physiolo2.35671954
16MP0010234_abnormal_vibrissa_follicle2.29362896
17MP0005275_abnormal_skin_tensile2.24873065
18MP0008438_abnormal_cutaneous_collagen2.21800677
19MP0003279_aneurysm2.07996195
20MP0005666_abnormal_adipose_tissue2.02189856
21MP0004130_abnormal_muscle_cell1.92699453
22MP0002254_reproductive_system_inflammat1.92691634
23MP0009840_abnormal_foam_cell1.91006993
24MP0002118_abnormal_lipid_homeostasis1.80214407
25MP0003191_abnormal_cellular_cholesterol1.79130424
26MP0005670_abnormal_white_adipose1.77964735
27MP0005332_abnormal_amino_acid1.75948734
28MP0005083_abnormal_biliary_tract1.74730878
29MP0001666_abnormal_nutrient_absorption1.72577093
30MP0002837_dystrophic_cardiac_calcinosis1.68363334
31MP0004272_abnormal_basement_membrane1.61147033
32MP0010030_abnormal_orbit_morphology1.61046026
33MP0000013_abnormal_adipose_tissue1.60363465
34MP0005375_adipose_tissue_phenotype1.59328590
35MP0003195_calcinosis1.58056608
36MP0001958_emphysema1.56198698
37MP0002877_abnormal_melanocyte_morpholog1.53809869
38MP0002909_abnormal_adrenal_gland1.45780483
39MP0003329_amyloid_beta_deposits1.44251042
40MP0005623_abnormal_meninges_morphology1.44112295
41MP0008961_abnormal_basal_metabolism1.43026413
42MP0000609_abnormal_liver_physiology1.42704869
43MP0004858_abnormal_nervous_system1.41320068
44MP0002971_abnormal_brown_adipose1.39838678
45MP0003806_abnormal_nucleotide_metabolis1.39003265
46MP0003942_abnormal_urinary_system1.33691326
47MP0000462_abnormal_digestive_system1.29932065
48MP0003950_abnormal_plasma_membrane1.29918298
49MP0000003_abnormal_adipose_tissue1.29757378
50MP0001188_hyperpigmentation1.28708879
51MP0005508_abnormal_skeleton_morphology1.26398243
52MP0000534_abnormal_ureter_morphology1.23033708
53MP0002108_abnormal_muscle_morphology1.21562251
54MP0005409_darkened_coat_color1.17756780
55MP0002060_abnormal_skin_morphology1.15492996
56MP0005501_abnormal_skin_physiology1.14099066
57MP0005319_abnormal_enzyme/_coenzyme1.13698787
58MP0003283_abnormal_digestive_organ1.11970891
59MP0009250_abnormal_appendicular_skeleto1.08655384
60MP0004019_abnormal_vitamin_homeostasis1.08596198
61MP0000566_synostosis1.07506315
62MP0002078_abnormal_glucose_homeostasis1.07016679
63MP0004043_abnormal_pH_regulation1.05591405
64MP0000428_abnormal_craniofacial_morphol1.04964377
65MP0005334_abnormal_fat_pad1.03176612
66MP0003755_abnormal_palate_morphology1.01782870
67MP0005023_abnormal_wound_healing1.01733155
68MP0003123_paternal_imprinting1.01447463
69MP0001542_abnormal_bone_strength1.00871939
70MP0010368_abnormal_lymphatic_system1.00838319
71MP0005535_abnormal_body_temperature0.99771918
72MP0005584_abnormal_enzyme/coenzyme_acti0.97975527
73MP0005248_abnormal_Harderian_gland0.97264980
74MP0000767_abnormal_smooth_muscle0.97001755
75MP0000604_amyloidosis0.96758705
76MP0000049_abnormal_middle_ear0.93900893
77MP0009053_abnormal_anal_canal0.93338776
78MP0003385_abnormal_body_wall0.93204483
79MP0002938_white_spotting0.92698232
80MP0003566_abnormal_cell_adhesion0.92496958
81MP0009384_cardiac_valve_regurgitation0.91262413
82MP0003868_abnormal_feces_composition0.87959246
83MP0002896_abnormal_bone_mineralization0.87112690
84MP0000163_abnormal_cartilage_morphology0.85821369
85MP0005448_abnormal_energy_balance0.85609262
86MP0009643_abnormal_urine_homeostasis0.85283709
87MP0002697_abnormal_eye_size0.85261517
88MP0003453_abnormal_keratinocyte_physiol0.84859540
89MP0002233_abnormal_nose_morphology0.84123539
90MP0002970_abnormal_white_adipose0.84066317
91MP0003011_delayed_dark_adaptation0.82784791
92MP0000678_abnormal_parathyroid_gland0.82168573
93MP0009115_abnormal_fat_cell0.81942119
94MP0004134_abnormal_chest_morphology0.81123430
95MP0001944_abnormal_pancreas_morphology0.80938522
96MP0001879_abnormal_lymphatic_vessel0.80194343
97MP0006138_congestive_heart_failure0.79986086
98MP0009672_abnormal_birth_weight0.78990878
99MP0005330_cardiomyopathy0.78547512
100MP0003300_gastrointestinal_ulcer0.76262278
101MP0005408_hypopigmentation0.75170812
102MP0003937_abnormal_limbs/digits/tail_de0.75098305
103MP0005197_abnormal_uvea_morphology0.74456716
104MP0003890_abnormal_embryonic-extraembry0.73167168
105MP0004264_abnormal_extraembryonic_tissu0.72215151
106MP0005379_endocrine/exocrine_gland_phen0.72187459
107MP0000432_abnormal_head_morphology0.71624793
108MP0003186_abnormal_redox_activity0.71614213
109MP0003959_abnormal_lean_body0.71252817
110MP0002116_abnormal_craniofacial_bone0.70718390
111MP0000747_muscle_weakness0.70480184
112MP0010352_gastrointestinal_tract_polyps0.70420864
113MP0010771_integument_phenotype0.70290322
114MP0004087_abnormal_muscle_fiber0.68374035
115MP0002269_muscular_atrophy0.66991243
116MP0005451_abnormal_body_composition0.66612373
117MP0010386_abnormal_urinary_bladder0.65880594
118MP0000467_abnormal_esophagus_morphology0.65842136
119MP0005595_abnormal_vascular_smooth0.65659681
120MP0002177_abnormal_outer_ear0.65180112
121MP0003091_abnormal_cell_migration0.65045974
122MP0003935_abnormal_craniofacial_develop0.64966862
123MP0001756_abnormal_urination0.64297391
124MP0003045_fibrosis0.63544600
125MP0002295_abnormal_pulmonary_circulatio0.63349748
126MP0002115_abnormal_skeleton_extremities0.63239504
127MP0002332_abnormal_exercise_endurance0.63152525
128MP0004885_abnormal_endolymph0.63110525
129MP0000751_myopathy0.62152662
130MP0001243_abnormal_dermal_layer0.62011063
131MP0001286_abnormal_eye_development0.61653900
132MP0004859_abnormal_synaptic_plasticity0.60918920
133MP0000579_abnormal_nail_morphology0.60169009
134MP0003690_abnormal_glial_cell0.59840026
135MP0003122_maternal_imprinting0.59725066
136MP0005076_abnormal_cell_differentiation0.59386159
137MP0002090_abnormal_vision0.59036096
138MP0001177_atelectasis0.58393721
139MP0000762_abnormal_tongue_morphology0.57917735
140MP0003075_altered_response_to0.56088918
141MP0000598_abnormal_liver_morphology0.55034753
142MP0002234_abnormal_pharynx_morphology0.53400165
143MP0001216_abnormal_epidermal_layer0.53065090
144MP0003953_abnormal_hormone_level0.52819116
145MP0001299_abnormal_eye_distance/0.51191491
146MP0000639_abnormal_adrenal_gland0.51009128
147MP0002876_abnormal_thyroid_physiology0.50533063
148MP0001348_abnormal_lacrimal_gland0.50125885
149MP0001881_abnormal_mammary_gland0.49518458
150MP0001765_abnormal_ion_homeostasis0.49483929

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.84791168
2Xanthomatosis (HP:0000991)4.59792311
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.29311526
4Intrahepatic cholestasis (HP:0001406)4.19720146
5Broad metatarsal (HP:0001783)3.71583966
6Hypobetalipoproteinemia (HP:0003563)3.63902423
7Abnormality of monocarboxylic acid metabolism (HP:0010996)3.62701741
8Vascular tortuosity (HP:0004948)3.56638352
9Abnormality of the Achilles tendon (HP:0005109)3.46150489
10Hyperlipoproteinemia (HP:0010980)3.45287689
11Ketosis (HP:0001946)3.39609544
12Hypoglycemic coma (HP:0001325)3.35527370
13Ankle contracture (HP:0006466)3.33994729
14Arterial tortuosity (HP:0005116)3.28238598
15Soft skin (HP:0000977)3.27639064
16Ketoacidosis (HP:0001993)3.24411819
17Achilles tendon contracture (HP:0001771)3.20753139
18Epidermoid cyst (HP:0200040)3.19286593
19Aortic dissection (HP:0002647)3.17967310
20Abnormality of dentin (HP:0010299)3.17300489
21Hypolipoproteinemia (HP:0010981)3.15123620
22Abnormality of glycine metabolism (HP:0010895)3.13011645
23Abnormality of serine family amino acid metabolism (HP:0010894)3.13011645
24Hypoalphalipoproteinemia (HP:0003233)3.12395566
25Turricephaly (HP:0000262)3.10052855
26Hyperglycinuria (HP:0003108)3.08095216
27Hyperglycinemia (HP:0002154)3.03754562
28Skin nodule (HP:0200036)3.00059997
29Hyperinsulinemic hypoglycemia (HP:0000825)2.91650679
30Complement deficiency (HP:0004431)2.91545928
31Cardiovascular calcification (HP:0011915)2.91042534
32Aortic aneurysm (HP:0004942)2.89478105
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.89379146
34Premature rupture of membranes (HP:0001788)2.86990653
35Hyperammonemia (HP:0001987)2.83238924
36Abnormality of glutamine family amino acid metabolism (HP:0010902)2.74676191
37Abnormality of the common coagulation pathway (HP:0010990)2.74465630
38Abnormality of the intrinsic pathway (HP:0010989)2.73724464
39Neonatal short-limb short stature (HP:0008921)2.68834171
40Follicular hyperkeratosis (HP:0007502)2.67330798
41Abnormal gallbladder physiology (HP:0012438)2.66593074
42Cholecystitis (HP:0001082)2.66593074
43Fragile skin (HP:0001030)2.63953346
44Wormian bones (HP:0002645)2.63088606
45Atrophic scars (HP:0001075)2.62901023
46Cerebral inclusion bodies (HP:0100314)2.59030925
47Bladder diverticulum (HP:0000015)2.58482111
48Protrusio acetabuli (HP:0003179)2.54520977
49Acanthosis nigricans (HP:0000956)2.53354185
50Abnormality of the lower motor neuron (HP:0002366)2.48841552
51Abnormal cartilage morphology (HP:0002763)2.45840085
52Symptomatic seizures (HP:0011145)2.45309520
53Vascular calcification (HP:0004934)2.43062640
54Prolonged partial thromboplastin time (HP:0003645)2.42111857
55Spinal rigidity (HP:0003306)2.41796691
56Hyperextensible skin (HP:0000974)2.39938324
57Back pain (HP:0003418)2.38444489
58Right ventricular cardiomyopathy (HP:0011663)2.37787693
59Vertebral compression fractures (HP:0002953)2.36802683
60Abnormality of complement system (HP:0005339)2.30476853
61Abnormal gallbladder morphology (HP:0012437)2.29794465
62Hyperglycemia (HP:0003074)2.29053183
63Cholelithiasis (HP:0001081)2.28576501
64Hypercholesterolemia (HP:0003124)2.26272721
65Cerebral aneurysm (HP:0004944)2.25599091
66Genu recurvatum (HP:0002816)2.25517741
67Hyporeflexia of lower limbs (HP:0002600)2.24862471
68Neurofibrillary tangles (HP:0002185)2.23934037
69Hyperphosphatemia (HP:0002905)2.21278254
70Cervical subluxation (HP:0003308)2.16449334
71Myocardial infarction (HP:0001658)2.15975527
72Type 1 muscle fiber predominance (HP:0003803)2.15783221
73Hypoglycemic seizures (HP:0002173)2.15410613
74Peritonitis (HP:0002586)2.13581098
75Blue sclerae (HP:0000592)2.11929530
76Overgrowth (HP:0001548)2.11884576
77Bronchomalacia (HP:0002780)2.11257345
78Abnormality of proline metabolism (HP:0010907)2.08224430
79Hydroxyprolinuria (HP:0003080)2.08224430
80Congenital glaucoma (HP:0001087)2.05582988
81Global brain atrophy (HP:0002283)2.02584515
82Abnormality of sulfur amino acid metabolism (HP:0004339)2.02246307
83Coronal craniosynostosis (HP:0004440)2.01999778
84Increased connective tissue (HP:0009025)1.98969243
85Fat malabsorption (HP:0002630)1.98635888
86Malnutrition (HP:0004395)1.97560577
87Oligomenorrhea (HP:0000876)1.96648827
88Abnormality of the acetabulum (HP:0003170)1.95605763
89Myoglobinuria (HP:0002913)1.95573466
90Gout (HP:0001997)1.93850474
91Pseudobulbar signs (HP:0002200)1.93518197
92Mitral stenosis (HP:0001718)1.91296037
93Lymphangioma (HP:0100764)1.90962747
94Abnormality of fatty-acid metabolism (HP:0004359)1.88997506
95Delayed CNS myelination (HP:0002188)1.88091238
96Amyloidosis (HP:0011034)1.86943540
97Increased variability in muscle fiber diameter (HP:0003557)1.86776327
98Unilateral renal agenesis (HP:0000122)1.86495428
99Abnormality of purine metabolism (HP:0004352)1.86493954
100Late onset (HP:0003584)1.86079561
101Shallow orbits (HP:0000586)1.85270707
102Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.82022733
103Upper limb amyotrophy (HP:0009129)1.81702711
104Distal upper limb amyotrophy (HP:0007149)1.81702711
105Mitral valve prolapse (HP:0001634)1.81149852
106Joint laxity (HP:0001388)1.80138404
107Hepatocellular carcinoma (HP:0001402)1.79925680
108Conjunctival hamartoma (HP:0100780)1.79434714
109Multiple enchondromatosis (HP:0005701)1.79225182
110Mildly elevated creatine phosphokinase (HP:0008180)1.78201802
111Wide anterior fontanel (HP:0000260)1.77853340
112Neonatal onset (HP:0003623)1.76936099
113Abnormal delivery (HP:0001787)1.76932555
114Ectopia lentis (HP:0001083)1.76280516
115Insulin resistance (HP:0000855)1.74883513
116Osteoarthritis (HP:0002758)1.74779394
117Hamartoma of the eye (HP:0010568)1.74535111
118Abnormality of vitamin metabolism (HP:0100508)1.73693758
119Buphthalmos (HP:0000557)1.73152393
120Irritability (HP:0000737)1.72351344
121Aneurysm (HP:0002617)1.71925799
122Abnormality of the gallbladder (HP:0005264)1.71291276
123Abnormal hemoglobin (HP:0011902)1.70539389
124Abnormality of molar morphology (HP:0011070)1.70064186
125Abnormality of molar (HP:0011077)1.70064186
126Status epilepticus (HP:0002133)1.69056492
127Hypoventilation (HP:0002791)1.67142579
128Abnormality of endocrine pancreas physiology (HP:0012093)1.66773273
129Abnormality of the pancreatic islet cells (HP:0006476)1.66773273
130Aortic regurgitation (HP:0001659)1.66251952
131Difficulty running (HP:0009046)1.63522249
132Ankyloglossia (HP:0010296)1.63295292
133Hypercortisolism (HP:0001578)1.63028063
134Spastic diplegia (HP:0001264)1.62595167
135Resting tremor (HP:0002322)1.62130900
136Proximal tubulopathy (HP:0000114)1.62110581
137Abnormality of aspartate family amino acid metabolism (HP:0010899)1.61035094
138Hyperbilirubinemia (HP:0002904)1.59894279
139Hyperthyroidism (HP:0000836)1.59518262
140Biconcave vertebral bodies (HP:0004586)1.59276127
141Hyperparathyroidism (HP:0000843)1.58638523
142Bowel diverticulosis (HP:0005222)1.57801145
143Testicular atrophy (HP:0000029)1.57588246
144Rickets (HP:0002748)1.54872928
145Metabolic acidosis (HP:0001942)1.54622699
146Nonimmune hydrops fetalis (HP:0001790)1.54600776
147Venous abnormality (HP:0002624)1.53155377
148Dilatation of the ascending aorta (HP:0005111)1.51149787
149Slender build (HP:0001533)1.50049804
150Focal segmental glomerulosclerosis (HP:0000097)1.49519994
151Enlarged penis (HP:0000040)1.48920235
152Elbow flexion contracture (HP:0002987)1.47105722
153Ovoid vertebral bodies (HP:0003300)1.46652449
154Coxa vara (HP:0002812)1.46581236
155Mitral regurgitation (HP:0001653)1.45387954
156Pterygium (HP:0001059)1.44814368
157Osteolytic defects of the phalanges of the hand (HP:0009771)1.44421178
158Osteolytic defects of the hand bones (HP:0009699)1.44421178
159Partial duplication of the phalanx of hand (HP:0009999)1.43752159
160Rhizomelia (HP:0008905)1.43213188
161Pancreatic islet-cell hyperplasia (HP:0004510)1.42693173
162Breech presentation (HP:0001623)1.42509384
163Knee flexion contracture (HP:0006380)1.42459437
164Limited hip movement (HP:0008800)1.40180311
165Abnormality of permanent molar morphology (HP:0011071)1.39990440
166Abnormality of the dental root (HP:0006486)1.39990440
167Taurodontia (HP:0000679)1.39990440

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.49031880
2ERN13.06206929
3PKN22.94399388
4MYLK2.92031715
5SIK12.74892081
6BCKDK2.60382598
7PDGFRA2.25618852
8LATS22.16106595
9TNIK2.10463769
10MAP3K22.10165413
11PNCK2.06219893
12STK242.01364157
13NTRK11.97932135
14MAP2K41.82547201
15RIPK11.81178904
16NEK91.76652604
17PRKD31.72900294
18FER1.70811374
19LATS11.68195358
20KSR21.67281573
21TESK11.65839105
22TRPM71.65717771
23AKT31.59312863
24FRK1.58802980
25MAP3K91.58714737
26DDR21.54814612
27TYRO31.49060624
28GRK51.43620377
29MST1R1.43599902
30PTK61.42541168
31BMX1.39654523
32RET1.39038261
33STK38L1.32709595
34MET1.29786097
35FGFR21.28791643
36EPHA21.27272243
37BRSK21.26444127
38WNK41.20711798
39FGFR41.20485850
40PRKG21.19972340
41WNK11.19848983
42CASK1.19263281
43NTRK31.16374831
44PAK31.13000742
45PTK21.09966154
46LIMK11.09673379
47MST41.08725678
48ICK1.08163211
49CDK121.06275702
50PDK31.06257885
51PDK41.06257885
52CAMK1D1.04093735
53LMTK20.98569107
54CAMK1G0.98567255
55EPHA40.95727292
56MAP3K10.95366410
57MAP3K100.93680086
58ALK0.93109466
59DAPK20.92020763
60TAF10.90840340
61MAP2K10.90828211
62PAK60.89889030
63MAP3K40.89133988
64MAP3K70.88744073
65STK390.88605192
66EIF2AK10.87324501
67STK380.86888558
68ILK0.84567508
69MAP3K30.84371053
70EPHB20.84259245
71MAP3K120.84230207
72TAOK10.83680508
73MINK10.83438574
74TGFBR20.83117715
75PASK0.82201927
76PRKCH0.81099163
77MTOR0.79522578
78PAK40.76966482
79INSRR0.75171540
80EEF2K0.74770608
81EPHB10.74103207
82PRKD10.73011283
83CAMKK10.71327899
84SCYL20.70280884
85GRK10.70157852
86PRKCE0.68266415
87FLT30.67752317
88FGFR10.67713567
89PDPK10.67240858
90PDGFRB0.67191792
91HIPK20.66428964
92TTK0.66255462
93CDK60.65728139
94DMPK0.65570131
95JAK20.65222983
96GSK3A0.64927255
97ABL20.63550812
98MAP3K110.63511424
99CAMK2D0.63414289
100TAOK30.62920030
101MOS0.62662121
102PAK20.62359147
103DYRK1B0.61538798
104PTK2B0.61425061
105TTN0.60577100
106STK110.60119634
107FGFR30.60033300
108ROCK20.59738647
109STK30.59498619
110PRKCG0.59148676
111PHKG10.58892343
112PHKG20.58892343
113NEK20.58026460
114ERBB40.57978463
115MKNK20.56958526
116NLK0.56911237
117LRRK20.56405255
118GRK60.55638483
119ROCK10.55169531
120MARK20.55095382
121STK160.54731942
122MAP3K60.54536302
123UHMK10.54035904
124DAPK30.51324887
125PRKAA20.50362701
126PLK30.50361603
127STK40.49358693
128PLK20.48203058
129PINK10.48177516
130PRKAA10.48104412
131PRKACG0.47893981
132MAPK70.47143771
133CDK50.46498679
134PIK3CA0.45821514
135PRKD20.45368268
136WEE10.45263019
137CDC42BPA0.45065183
138PDK10.44509431
139MAP2K20.43774575
140PDK20.43758589
141TIE10.43648498
142ADRBK10.42268346
143PIK3CG0.41009798
144CAMK10.40733629
145BRSK10.40409757
146PRKCZ0.40232914
147CSNK1E0.37830438
148CDK30.37158824
149WNK30.36617154
150MAPKAPK30.36284854
151BRAF0.36115451

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.56603017
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.83220689
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.61030677
4Arginine biosynthesis_Homo sapiens_hsa002202.46782920
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.41848863
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35796430
7Fatty acid degradation_Homo sapiens_hsa000712.20752784
8Tryptophan metabolism_Homo sapiens_hsa003802.14513130
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.14029233
10PPAR signaling pathway_Homo sapiens_hsa033202.11392908
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.08351355
12Propanoate metabolism_Homo sapiens_hsa006402.08011521
13Butanoate metabolism_Homo sapiens_hsa006502.05823899
14Fatty acid metabolism_Homo sapiens_hsa012121.97786792
15Vitamin digestion and absorption_Homo sapiens_hsa049771.91936432
16Sulfur metabolism_Homo sapiens_hsa009201.65614276
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.60302877
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58255454
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57685133
20Complement and coagulation cascades_Homo sapiens_hsa046101.55379194
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55342174
22Bile secretion_Homo sapiens_hsa049761.53690547
23Protein export_Homo sapiens_hsa030601.52269201
24Phenylalanine metabolism_Homo sapiens_hsa003601.49448649
25Fat digestion and absorption_Homo sapiens_hsa049751.49149280
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.48104188
27Renin-angiotensin system_Homo sapiens_hsa046141.43096679
28Fatty acid biosynthesis_Homo sapiens_hsa000611.42077749
29Histidine metabolism_Homo sapiens_hsa003401.39084229
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37699861
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36225577
32Pyruvate metabolism_Homo sapiens_hsa006201.35854517
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.35808042
34beta-Alanine metabolism_Homo sapiens_hsa004101.33420480
35Chemical carcinogenesis_Homo sapiens_hsa052041.26575540
36Peroxisome_Homo sapiens_hsa041461.23851640
37Tyrosine metabolism_Homo sapiens_hsa003501.23077686
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22212099
39Mineral absorption_Homo sapiens_hsa049781.22141611
40Carbon metabolism_Homo sapiens_hsa012001.18553074
41Starch and sucrose metabolism_Homo sapiens_hsa005001.13596592
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12073831
43Fatty acid elongation_Homo sapiens_hsa000621.10054532
44Basal cell carcinoma_Homo sapiens_hsa052171.08212628
45Glycerolipid metabolism_Homo sapiens_hsa005611.03081335
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01037917
47Caffeine metabolism_Homo sapiens_hsa002320.97874492
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94438213
49Hedgehog signaling pathway_Homo sapiens_hsa043400.93150508
50Retinol metabolism_Homo sapiens_hsa008300.92164259
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88419204
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88127120
53Adherens junction_Homo sapiens_hsa045200.88092444
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.87717504
55Biosynthesis of amino acids_Homo sapiens_hsa012300.87122192
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86135398
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85660668
58Hippo signaling pathway_Homo sapiens_hsa043900.84744606
59TGF-beta signaling pathway_Homo sapiens_hsa043500.82872625
60Glutathione metabolism_Homo sapiens_hsa004800.79968460
61ABC transporters_Homo sapiens_hsa020100.78714240
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77244763
63Selenocompound metabolism_Homo sapiens_hsa004500.77237662
64Steroid biosynthesis_Homo sapiens_hsa001000.77199297
65Lysine degradation_Homo sapiens_hsa003100.75231982
66N-Glycan biosynthesis_Homo sapiens_hsa005100.74760251
67AMPK signaling pathway_Homo sapiens_hsa041520.74452693
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.74290180
69Insulin resistance_Homo sapiens_hsa049310.73888446
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73286940
71Vitamin B6 metabolism_Homo sapiens_hsa007500.73114903
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69939519
73Tight junction_Homo sapiens_hsa045300.69046243
74Sphingolipid metabolism_Homo sapiens_hsa006000.67528123
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.66368287
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65648206
77Sulfur relay system_Homo sapiens_hsa041220.65041767
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61346994
79Arginine and proline metabolism_Homo sapiens_hsa003300.60528435
80Bladder cancer_Homo sapiens_hsa052190.60402337
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59256030
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.59194198
83Glucagon signaling pathway_Homo sapiens_hsa049220.58950338
84Dilated cardiomyopathy_Homo sapiens_hsa054140.58567491
85Type II diabetes mellitus_Homo sapiens_hsa049300.58476341
86Staphylococcus aureus infection_Homo sapiens_hsa051500.57178342
87Melanoma_Homo sapiens_hsa052180.55213300
88Wnt signaling pathway_Homo sapiens_hsa043100.55112090
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.53081101
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53004010
91Folate biosynthesis_Homo sapiens_hsa007900.52209612
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50691486
93Renin secretion_Homo sapiens_hsa049240.50181207
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49249771
95Insulin signaling pathway_Homo sapiens_hsa049100.48598476
96Circadian rhythm_Homo sapiens_hsa047100.48011703
97Prion diseases_Homo sapiens_hsa050200.47276762
98Ribosome_Homo sapiens_hsa030100.46905641
99One carbon pool by folate_Homo sapiens_hsa006700.46624357
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.46544645
101Thyroid cancer_Homo sapiens_hsa052160.46334985
102Cardiac muscle contraction_Homo sapiens_hsa042600.46284120
103Galactose metabolism_Homo sapiens_hsa000520.46159453
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44204769
105Insulin secretion_Homo sapiens_hsa049110.43475831
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43202311
107Protein digestion and absorption_Homo sapiens_hsa049740.40607336
108Dorso-ventral axis formation_Homo sapiens_hsa043200.40388493
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39852292
110mTOR signaling pathway_Homo sapiens_hsa041500.39531945
111Cocaine addiction_Homo sapiens_hsa050300.37648972
112Estrogen signaling pathway_Homo sapiens_hsa049150.37573583
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37221379
114Thyroid hormone synthesis_Homo sapiens_hsa049180.37021086
115ECM-receptor interaction_Homo sapiens_hsa045120.36920223
116Glioma_Homo sapiens_hsa052140.36890824
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35993056
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34971182
119GABAergic synapse_Homo sapiens_hsa047270.33859399
120Fructose and mannose metabolism_Homo sapiens_hsa000510.32084695
121Amoebiasis_Homo sapiens_hsa051460.31477075
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.31098232
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30927800
124Proteoglycans in cancer_Homo sapiens_hsa052050.30462907
125Melanogenesis_Homo sapiens_hsa049160.30402110
126Focal adhesion_Homo sapiens_hsa045100.28685682
127Amphetamine addiction_Homo sapiens_hsa050310.28516427
128Dopaminergic synapse_Homo sapiens_hsa047280.28281570

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