PGS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of other organism (GO:0098543)4.64461852
2detection of bacterium (GO:0016045)4.39767305
3regulation of early endosome to late endosome transport (GO:2000641)4.35082033
4regulation of B cell receptor signaling pathway (GO:0050855)4.27495913
5regulation of interferon-beta biosynthetic process (GO:0045357)4.26518163
6negative regulation of cell killing (GO:0031342)4.10150504
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.10150504
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.06831720
9cellular extravasation (GO:0045123)4.05203645
10detection of molecule of bacterial origin (GO:0032490)4.03679971
11response to interleukin-15 (GO:0070672)4.00501998
12detection of external biotic stimulus (GO:0098581)3.99252019
13positive regulation of gamma-delta T cell activation (GO:0046645)3.98047542
14regulation of translational termination (GO:0006449)3.79063575
15neutrophil activation (GO:0042119)3.78885519
16germinal center formation (GO:0002467)3.73778174
17NIK/NF-kappaB signaling (GO:0038061)3.72901375
18negative regulation of lymphocyte mediated immunity (GO:0002707)3.72714775
19myeloid cell activation involved in immune response (GO:0002275)3.66995394
20cellular response to interleukin-15 (GO:0071350)3.63763860
21granulocyte activation (GO:0036230)3.61493978
22negative regulation of erythrocyte differentiation (GO:0045647)3.61104387
23detection of biotic stimulus (GO:0009595)3.59960633
24respiratory burst (GO:0045730)3.53236995
25leukocyte migration involved in inflammatory response (GO:0002523)3.50637073
26macrophage activation (GO:0042116)3.50227075
27neutrophil mediated immunity (GO:0002446)3.45252854
28regulation of mast cell degranulation (GO:0043304)3.44535505
29natural killer cell mediated immunity (GO:0002228)3.44352185
30natural killer cell mediated cytotoxicity (GO:0042267)3.44352185
31negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.43284813
32negative regulation of leukocyte mediated immunity (GO:0002704)3.40024140
33microglial cell activation (GO:0001774)3.38247802
34B cell receptor signaling pathway (GO:0050853)3.37614352
35antigen processing and presentation via MHC class Ib (GO:0002475)3.35171606
36lipopolysaccharide-mediated signaling pathway (GO:0031663)3.33724115
37negative regulation of T cell mediated immunity (GO:0002710)3.32032805
38positive regulation by symbiont of host defense response (GO:0052509)3.31579344
39modulation by symbiont of host defense response (GO:0052031)3.31579344
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.31579344
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.31579344
42positive regulation by organism of defense response of other organism involved in symbiotic interact3.31579344
43modulation by symbiont of host immune response (GO:0052553)3.31579344
44regulation of dendritic cell antigen processing and presentation (GO:0002604)3.21348371
45regulation of myeloid leukocyte mediated immunity (GO:0002886)3.20682919
46positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.18552829
47tolerance induction (GO:0002507)3.18015861
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.14067875
49antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.14067875
50immunoglobulin mediated immune response (GO:0016064)3.13650946
51regulation of T-helper 2 cell differentiation (GO:0045628)3.11609029
52leukocyte degranulation (GO:0043299)3.11254360
53production of molecular mediator involved in inflammatory response (GO:0002532)3.10603273
54negative regulation of T-helper cell differentiation (GO:0045623)3.09757615
55negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.09757615
56negative regulation of interleukin-6 production (GO:0032715)3.08990929
57regulation of mast cell activation involved in immune response (GO:0033006)3.08548152
58positive regulation of interferon-alpha production (GO:0032727)3.07142907
59positive regulation of B cell differentiation (GO:0045579)3.06046317
60regulation of leukocyte degranulation (GO:0043300)3.05831926
61regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.04822193
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.04397365
63response to protozoan (GO:0001562)3.03084697
64negative thymic T cell selection (GO:0045060)3.01285024
65regulation of interferon-alpha production (GO:0032647)2.99904144
66regulation of mast cell activation (GO:0033003)2.97738046
67positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.97097562
68myeloid leukocyte mediated immunity (GO:0002444)2.95165906
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.94967317
70negative T cell selection (GO:0043383)2.93747598
71negative regulation of cytokine production involved in immune response (GO:0002719)2.88937347
72regulation of B cell differentiation (GO:0045577)2.88545782
73positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.88261524
74positive regulation of mast cell activation (GO:0033005)2.86646969
75barbed-end actin filament capping (GO:0051016)2.86553002
76T cell migration (GO:0072678)2.85271195
77response to muramyl dipeptide (GO:0032495)2.84427717
78regulation of gamma-delta T cell activation (GO:0046643)2.83555812
79regulation of integrin activation (GO:0033623)2.80673894
80regulation of alpha-beta T cell proliferation (GO:0046640)2.78444795
81myeloid leukocyte activation (GO:0002274)2.78388771
82regulation of tolerance induction (GO:0002643)2.74904962
83T-helper 1 type immune response (GO:0042088)2.74374160
84negative regulation of toll-like receptor signaling pathway (GO:0034122)2.74075248
85antigen processing and presentation of endogenous antigen (GO:0019883)2.70496445
86regulation of interleukin-12 biosynthetic process (GO:0045075)2.66558687
87macrophage activation involved in immune response (GO:0002281)2.65955260
88Arp2/3 complex-mediated actin nucleation (GO:0034314)2.65535558
89interferon-gamma-mediated signaling pathway (GO:0060333)2.63579296
90leukocyte mediated cytotoxicity (GO:0001909)2.63318214
91response to peptidoglycan (GO:0032494)2.62221929
92modulation by symbiont of host cellular process (GO:0044068)2.61444487
93mitotic G1 DNA damage checkpoint (GO:0031571)2.60166786
94negative regulation of interleukin-12 production (GO:0032695)2.59506909
95cell adhesion mediated by integrin (GO:0033627)2.59437802
96negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.57791722
97regulation of type I interferon-mediated signaling pathway (GO:0060338)2.54434499
98regulation of gamma-delta T cell differentiation (GO:0045586)2.53349521
99B cell mediated immunity (GO:0019724)2.53173442
100positive thymic T cell selection (GO:0045059)2.46541777
101positive regulation of Cdc42 GTPase activity (GO:0043089)2.44798102
102regulation of histone phosphorylation (GO:0033127)2.42987450
103NLS-bearing protein import into nucleus (GO:0006607)2.42175300
104protein localization to endosome (GO:0036010)2.40586467
105response to host (GO:0075136)2.37328339
106response to host defenses (GO:0052200)2.37328339
107response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.37328339
108JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.35152486
109nuclear envelope disassembly (GO:0051081)2.34808866
110membrane disassembly (GO:0030397)2.34808866
111negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.34614924
112response to host immune response (GO:0052572)2.34269935
113response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.34269935
114positive regulation of actin cytoskeleton reorganization (GO:2000251)2.33980750
115mitotic nuclear envelope disassembly (GO:0007077)2.33124876
116regulation of RIG-I signaling pathway (GO:0039535)2.32442100
117regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.31922088
118positive regulation of lamellipodium assembly (GO:0010592)2.31299346
119cellular response to type I interferon (GO:0071357)2.31186934
120type I interferon signaling pathway (GO:0060337)2.31186934
121response to type I interferon (GO:0034340)2.30604703
122actin nucleation (GO:0045010)2.30481321
123regulation of response to interferon-gamma (GO:0060330)2.30127452
124regulation of defense response to virus by virus (GO:0050690)2.27658031
125T cell apoptotic process (GO:0070231)2.27188935
126negative regulation of cell size (GO:0045792)2.26882168
127mitotic G1/S transition checkpoint (GO:0044819)2.25235414
128regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.23657479
129histone H2A monoubiquitination (GO:0035518)2.22921429
130positive regulation of lamellipodium organization (GO:1902745)2.22558546
131response to interferon-alpha (GO:0035455)2.21822432
132lymphocyte mediated immunity (GO:0002449)2.21183971
133pre-miRNA processing (GO:0031054)2.18312333
134cortical actin cytoskeleton organization (GO:0030866)2.17559457
135histone H2A ubiquitination (GO:0033522)2.17409080
136activation of JUN kinase activity (GO:0007257)2.17071606
137regulation of exit from mitosis (GO:0007096)2.17007059
138cytoskeletal anchoring at plasma membrane (GO:0007016)2.16856661
139positive regulation of T cell apoptotic process (GO:0070234)2.15985201
140regulation of clathrin-mediated endocytosis (GO:2000369)2.15000017
141negative regulation of innate immune response (GO:0045824)2.08968590
142neutrophil activation involved in immune response (GO:0002283)2.07842604
143apoptotic cell clearance (GO:0043277)2.07586378
144chaperone mediated protein folding requiring cofactor (GO:0051085)2.06926651
145positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.06889969
146nuclear envelope organization (GO:0006998)2.06661188
147sequestering of actin monomers (GO:0042989)2.06211960
148positive regulation of lymphocyte apoptotic process (GO:0070230)2.05621919
149apoptotic process involved in morphogenesis (GO:0060561)2.05555545
150leukocyte aggregation (GO:0070486)2.05330915
151DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.04403351
152defense response to protozoan (GO:0042832)2.03118897
153cellular response to nerve growth factor stimulus (GO:1990090)2.03025965
154response to nerve growth factor (GO:1990089)2.03025965
155regulation of mitotic spindle organization (GO:0060236)2.02938924
156leukocyte cell-cell adhesion (GO:0007159)2.02791749
157regulation of NFAT protein import into nucleus (GO:0051532)2.02261488
158thymic T cell selection (GO:0045061)2.01806397
159positive regulation of cell adhesion mediated by integrin (GO:0033630)2.01748715
160positive regulation of histone acetylation (GO:0035066)2.01172693
161Fc-gamma receptor signaling pathway (GO:0038094)2.01030426

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.28883846
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.26322693
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.18406062
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.11270549
5E2F7_22180533_ChIP-Seq_HELA_Human2.77853776
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.74188268
7MYC_22102868_ChIP-Seq_BL_Human2.67757491
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.52157415
9VDR_21846776_ChIP-Seq_THP-1_Human2.51959121
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.27843084
11RUNX_20019798_ChIP-Seq_JUKART_Human2.26235699
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.15321796
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13179986
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.13019809
15* ELK3_25401928_ChIP-Seq_HUVEC_Human2.12922632
16* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.04410126
17KDM2B_26808549_Chip-Seq_DND41_Human1.99507059
18TCF7_22412390_ChIP-Seq_EML_Mouse1.98503175
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.89820584
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89060650
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88449206
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87642012
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86487301
24ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.84266248
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83508968
26SPI1_23127762_ChIP-Seq_K562_Human1.75472349
27MAF_26560356_Chip-Seq_TH1_Human1.75240789
28ZNF263_19887448_ChIP-Seq_K562_Human1.74361969
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70023762
30* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69348424
31ATF3_27146783_Chip-Seq_COLON_Human1.65388580
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64146423
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64054827
34GATA1_19941827_ChIP-Seq_MEL_Mouse1.63744128
35UTX_26944678_Chip-Seq_JUKART_Human1.63325604
36LXR_22292898_ChIP-Seq_THP-1_Human1.62321429
37RACK7_27058665_Chip-Seq_MCF-7_Human1.61009800
38* IRF8_27001747_Chip-Seq_BMDM_Mouse1.60562783
39VDR_24763502_ChIP-Seq_THP-1_Human1.59008381
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58513065
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.56583171
42* RUNX1_22412390_ChIP-Seq_EML_Mouse1.56268277
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53582300
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51725765
45* MYB_26560356_Chip-Seq_TH2_Human1.49161320
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46886609
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45982389
48GATA3_27048872_Chip-Seq_THYMUS_Human1.45872125
49* SPI1_23547873_ChIP-Seq_NB4_Human1.45833420
50MAF_26560356_Chip-Seq_TH2_Human1.39733855
51PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39336118
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39036941
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37540994
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.36916919
55* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35754944
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35567037
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35425625
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34437294
59PU.1_20513432_ChIP-Seq_Bcells_Mouse1.34029994
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33808010
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33586056
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31391234
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31344626
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31183054
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30915562
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30651173
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29955143
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28693867
69* MYB_26560356_Chip-Seq_TH1_Human1.27334149
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.27328307
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27285253
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26528256
73CIITA_25753668_ChIP-Seq_RAJI_Human1.26266321
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26166920
75TFEB_21752829_ChIP-Seq_HELA_Human1.26115788
76SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24999396
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23422192
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22594807
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21726508
80VDR_24787735_ChIP-Seq_THP-1_Human1.21392581
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21343552
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20949184
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19271101
84STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18648043
85NCOR1_26117541_ChIP-Seq_K562_Human1.18161173
86KDM2B_26808549_Chip-Seq_K562_Human1.18107678
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17734388
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16631541
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15544500
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15086526
91KDM2B_26808549_Chip-Seq_JURKAT_Human1.14587740
92P68_20966046_ChIP-Seq_HELA_Human1.14507949
93MYC_19079543_ChIP-ChIP_MESCs_Mouse1.14499610
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.14035834
95GATA1_19941826_ChIP-Seq_K562_Human1.13425027
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12833939
97CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12762584
98NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12036216
99PU_27001747_Chip-Seq_BMDM_Mouse1.11809053
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11410786
101MYC_18555785_ChIP-Seq_MESCs_Mouse1.11262703
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09728470
103FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09454635
104SMC4_20622854_ChIP-Seq_HELA_Human1.08897383
105BCOR_27268052_Chip-Seq_Bcells_Human1.08705909
106IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08369950
107* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08353539
108GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07972119
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07950366
110VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07453740
111* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06508478
112TP53_22127205_ChIP-Seq_IMR90_Human1.06493714
113POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05046260
114FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04157766
115SA1_27219007_Chip-Seq_ERYTHROID_Human1.04125960
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03933493
117* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02415332
118CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01866589
119* BCL6_27268052_Chip-Seq_Bcells_Human1.01806007
120* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01682109
121* GATA3_26560356_Chip-Seq_TH2_Human1.01169383
122XRN2_22483619_ChIP-Seq_HELA_Human1.00956748
123SCL_19346495_ChIP-Seq_HPC-7_Human0.99961506
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99836090
125HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99792921
126CTCF_21964334_Chip-Seq_Bcells_Human0.98838865
127NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98345628
128THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98144740
129MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97545176
130* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97513109
131CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97409845
132ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97066163
133* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96983654
134* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96343484
135CTCF_26484167_Chip-Seq_Bcells_Mouse0.93769751
136SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93174793

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.14870926
2MP0003303_peritoneal_inflammation2.75939264
3MP0009278_abnormal_bone_marrow2.55967987
4MP0003172_abnormal_lysosome_physiology2.46139917
5MP0004510_myositis2.45419096
6MP0005058_abnormal_lysosome_morphology2.37648233
7MP0004858_abnormal_nervous_system2.34357105
8MP0003705_abnormal_hypodermis_morpholog2.26897277
9MP0008260_abnormal_autophagy2.23376310
10MP0000685_abnormal_immune_system2.19997552
11MP0003436_decreased_susceptibility_to2.15432869
12MP0004947_skin_inflammation2.13371413
13MP0010352_gastrointestinal_tract_polyps2.11149835
14MP0005397_hematopoietic_system_phenotyp2.10111764
15MP0001545_abnormal_hematopoietic_system2.10111764
16MP0001958_emphysema2.04929533
17MP0010234_abnormal_vibrissa_follicle2.02612597
18MP0003693_abnormal_embryo_hatching1.98469591
19MP0010307_abnormal_tumor_latency1.97083459
20MP0003566_abnormal_cell_adhesion1.94149040
21MP0004859_abnormal_synaptic_plasticity1.92785391
22MP0005451_abnormal_body_composition1.82447186
23MP0005076_abnormal_cell_differentiation1.76968820
24MP0001835_abnormal_antigen_presentation1.75029984
25MP0009785_altered_susceptibility_to1.74361880
26MP0001790_abnormal_immune_system1.70890678
27MP0005387_immune_system_phenotype1.70890678
28MP0009764_decreased_sensitivity_to1.70150298
29MP0003111_abnormal_nucleus_morphology1.68198012
30MP0003300_gastrointestinal_ulcer1.67576151
31MP0005464_abnormal_platelet_physiology1.66348942
32MP0003091_abnormal_cell_migration1.66293420
33MP0003448_altered_tumor_morphology1.65761426
34MP0005000_abnormal_immune_tolerance1.64847153
35MP0000858_altered_metastatic_potential1.64616239
36MP0003329_amyloid_beta_deposits1.62709168
37MP0005023_abnormal_wound_healing1.60690568
38MP0005025_abnormal_response_to1.60663823
39MP0002132_abnormal_respiratory_system1.60561190
40MP0003828_pulmonary_edema1.57560850
41MP0000604_amyloidosis1.57297834
42MP0002452_abnormal_antigen_presenting1.54719560
43MP0002723_abnormal_immune_serum1.54482437
44MP0002419_abnormal_innate_immunity1.52059257
45MP0001819_abnormal_immune_cell1.47152902
46MP0001800_abnormal_humoral_immune1.46571004
47MP0002398_abnormal_bone_marrow1.46161363
48MP0002420_abnormal_adaptive_immunity1.45296558
49MP0002405_respiratory_system_inflammati1.44140256
50MP0003453_abnormal_keratinocyte_physiol1.41389203
51MP0003077_abnormal_cell_cycle1.40168266
52MP0004808_abnormal_hematopoietic_stem1.35196322
53MP0008469_abnormal_protein_level1.35000629
54MP0009840_abnormal_foam_cell1.32510144
55MP0004782_abnormal_surfactant_physiolog1.31426581
56MP0002998_abnormal_bone_remodeling1.30611077
57MP0005671_abnormal_response_to1.30310479
58MP0001849_ear_inflammation1.29872618
59MP0001730_embryonic_growth_arrest1.29458513
60MP0004957_abnormal_blastocyst_morpholog1.28327378
61MP0003646_muscle_fatigue1.28126830
62MP0003866_abnormal_defecation1.26953330
63MP0008004_abnormal_stomach_pH1.26145053
64MP0001853_heart_inflammation1.25042635
65MP0003763_abnormal_thymus_physiology1.23515934
66MP0005621_abnormal_cell_physiology1.21248806
67MP0000716_abnormal_immune_system1.20149593
68MP0009333_abnormal_splenocyte_physiolog1.18470116
69MP0000689_abnormal_spleen_morphology1.18007213
70MP0002722_abnormal_immune_system1.15265320
71MP0002396_abnormal_hematopoietic_system1.14966650
72MP0004381_abnormal_hair_follicle1.12269884
73MP0001533_abnormal_skeleton_physiology1.12263318
74MP0010155_abnormal_intestine_physiology1.11344202
75MP0000371_diluted_coat_color1.07681712
76MP0002429_abnormal_blood_cell1.07094428
77MP0000350_abnormal_cell_proliferation1.07026836
78MP0001851_eye_inflammation1.06786294
79MP0000465_gastrointestinal_hemorrhage1.06383692
80MP0000733_abnormal_muscle_development1.05675283
81MP0003183_abnormal_peptide_metabolism1.04961827
82MP0000343_altered_response_to1.04940055
83MP0002148_abnormal_hypersensitivity_rea1.03720852
84MP0000490_abnormal_crypts_of1.01829466
85MP0006082_CNS_inflammation1.01762360
86MP0002019_abnormal_tumor_incidence1.01625363
87MP0010094_abnormal_chromosome_stability1.00926380
88MP0003724_increased_susceptibility_to1.00412375
89MP0003656_abnormal_erythrocyte_physiolo0.99260341
90MP0000703_abnormal_thymus_morphology0.99017281
91MP0001845_abnormal_inflammatory_respons0.97923398
92MP0005390_skeleton_phenotype0.97561719
93MP0005083_abnormal_biliary_tract0.96190845
94MP0002006_tumorigenesis0.95489044
95MP0005257_abnormal_intraocular_pressure0.94298005
96MP0002653_abnormal_ependyma_morphology0.92923226
97MP0001663_abnormal_digestive_system0.91460370
98MP0002933_joint_inflammation0.90417242
99MP0005384_cellular_phenotype0.88388008
100MP0002277_abnormal_respiratory_mucosa0.87702620
101MP0003283_abnormal_digestive_organ0.85581184
102MP0002166_altered_tumor_susceptibility0.85392680
103MP0003690_abnormal_glial_cell0.83790440
104MP0004883_abnormal_blood_vessel0.82720773
105MP0000015_abnormal_ear_pigmentation0.81907645
106MP0005164_abnormal_response_to0.81311542
107MP0005166_decreased_susceptibility_to0.81028260
108MP0009763_increased_sensitivity_to0.80204382
109MP0005310_abnormal_salivary_gland0.80089796
110MP0003075_altered_response_to0.78681720
111MP0008961_abnormal_basal_metabolism0.77501749
112MP0004130_abnormal_muscle_cell0.77146072
113MP0002332_abnormal_exercise_endurance0.76449941
114MP0003045_fibrosis0.76044099
115MP0004185_abnormal_adipocyte_glucose0.75045907
116MP0005174_abnormal_tail_pigmentation0.74548171
117MP0005275_abnormal_skin_tensile0.73420369
118MP0001873_stomach_inflammation0.73374530
119MP0002080_prenatal_lethality0.73134555
120MP0003718_maternal_effect0.73079845
121MP0009765_abnormal_xenobiotic_induced0.72849820
122MP0002138_abnormal_hepatobiliary_system0.71941698
123MP0003191_abnormal_cellular_cholesterol0.70968025
124MP0000313_abnormal_cell_death0.70810373
125MP0002009_preneoplasia0.68772059
126MP0000358_abnormal_cell_content/0.67232018
127MP0005167_abnormal_blood-brain_barrier0.67078387
128MP0008874_decreased_physiological_sensi0.63806278
129MP0003221_abnormal_cardiomyocyte_apopto0.63461525
130MP0000249_abnormal_blood_vessel0.62315539
131MP0003795_abnormal_bone_structure0.59273600
132MP0002254_reproductive_system_inflammat0.54387066

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)4.46300867
2Gastrointestinal infarctions (HP:0005244)4.03963592
3Recurrent gram-negative bacterial infections (HP:0005420)3.92257597
4Keratoconjunctivitis sicca (HP:0001097)3.90172998
5Obstructive lung disease (HP:0006536)3.80200901
6Chronic obstructive pulmonary disease (HP:0006510)3.80200901
7Abnormal delayed hypersensitivity skin test (HP:0002963)3.79941116
8Meningitis (HP:0001287)3.67952897
9Keratoconjunctivitis (HP:0001096)3.63712512
10Chronic mucocutaneous candidiasis (HP:0002728)3.55495761
11Recurrent cutaneous fungal infections (HP:0011370)3.55495761
12Eczematoid dermatitis (HP:0000976)3.54227928
13Recurrent abscess formation (HP:0002722)3.42046318
14Encephalitis (HP:0002383)3.36789282
15Cerebral aneurysm (HP:0004944)3.26575747
16Elevated erythrocyte sedimentation rate (HP:0003565)3.20160344
17Prolonged bleeding time (HP:0003010)3.06909355
18Spontaneous hematomas (HP:0007420)3.04099985
19Urticaria (HP:0001025)3.01262471
20Chest pain (HP:0100749)3.00952486
21Recurrent bacterial skin infections (HP:0005406)3.00442619
22Hemoptysis (HP:0002105)2.99075771
23T lymphocytopenia (HP:0005403)2.90175616
24Dysostosis multiplex (HP:0000943)2.89677468
25Increased IgM level (HP:0003496)2.88280097
26Hypochromic anemia (HP:0001931)2.86590953
27Increased cerebral lipofuscin (HP:0011813)2.86183677
28Arterial thrombosis (HP:0004420)2.81323190
29Abnormality of T cell number (HP:0011839)2.80017102
30Difficulty climbing stairs (HP:0003551)2.73251254
31Annular pancreas (HP:0001734)2.72729692
32Myositis (HP:0100614)2.72112208
33Long toe (HP:0010511)2.72057588
34Episodic fever (HP:0001954)2.70108375
35Distal upper limb amyotrophy (HP:0007149)2.68967422
36Upper limb amyotrophy (HP:0009129)2.68967422
37Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.68622601
38Abnormality of macrophages (HP:0004311)2.68117841
39Hand muscle atrophy (HP:0009130)2.63331793
40Epistaxis (HP:0000421)2.58016372
41Panhypogammaglobulinemia (HP:0003139)2.57256836
42Anorexia (HP:0002039)2.56317245
43Hypochromic microcytic anemia (HP:0004840)2.54995049
44Inflammation of the large intestine (HP:0002037)2.54780970
45Nasal polyposis (HP:0100582)2.54764477
46Abnormality of the nasal mucosa (HP:0000433)2.54674905
47Mediastinal lymphadenopathy (HP:0100721)2.53478835
48Granulocytopenia (HP:0001913)2.52993693
49Amyloidosis (HP:0011034)2.50869188
50Gastrointestinal inflammation (HP:0004386)2.50672869
51Colitis (HP:0002583)2.47450802
52Frequent falls (HP:0002359)2.45720989
53Abnormality of the pleura (HP:0002103)2.43868322
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.42467063
55Abnormality of polysaccharide metabolism (HP:0011012)2.42467063
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.42467063
57Abnormality of T cells (HP:0002843)2.41720000
58Supranuclear gaze palsy (HP:0000605)2.41653139
59Abnormality of the fingertips (HP:0001211)2.39672751
60Pustule (HP:0200039)2.37580415
61Stomatitis (HP:0010280)2.35655137
62Mucopolysacchariduria (HP:0008155)2.34391334
63Urinary glycosaminoglycan excretion (HP:0003541)2.34391334
64Increased density of long bones (HP:0006392)2.33224136
65Increased serum ferritin (HP:0003281)2.33054644
66Pulmonary embolism (HP:0002204)2.32367085
67Radial bowing (HP:0002986)2.32262613
68Peritonitis (HP:0002586)2.32045170
69Agammaglobulinemia (HP:0004432)2.26174172
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.24666030
71Orchitis (HP:0100796)2.24540060
72Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.23788129
73Gangrene (HP:0100758)2.23659639
74Autoimmune thrombocytopenia (HP:0001973)2.23364411
75Abnormality of the peritoneum (HP:0002585)2.22408143
76Abnormality of the endocardium (HP:0004306)2.21815948
77Petechiae (HP:0000967)2.20805610
78Global brain atrophy (HP:0002283)2.20054034
79Dilatation of the ascending aorta (HP:0005111)2.19797209
80Achilles tendon contracture (HP:0001771)2.19345060
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.18067789
82Increased IgE level (HP:0003212)2.17598593
83Lymphopenia (HP:0001888)2.16573924
84Hematochezia (HP:0002573)2.16504694
85Keratitis (HP:0000491)2.16358224
86Genu recurvatum (HP:0002816)2.15652540
87Recurrent fungal infections (HP:0002841)2.15309119
88Short nail (HP:0001799)2.14432739
89Gingival bleeding (HP:0000225)2.13409718
90Sepsis (HP:0100806)2.10422539
91Diminished motivation (HP:0000745)2.10009929
92Hepatosplenomegaly (HP:0001433)2.09809572
93Chronic otitis media (HP:0000389)2.09788373
94Osteolytic defects of the phalanges of the hand (HP:0009771)2.08492002
95Osteolytic defects of the hand bones (HP:0009699)2.08492002
96Abnormality of cells of the lymphoid lineage (HP:0012140)2.08130274
97Abnormality of iron homeostasis (HP:0011031)2.08012851
98Abnormality of glycolipid metabolism (HP:0010969)2.05784357
99Abnormality of liposaccharide metabolism (HP:0010968)2.05784357
100Abnormality of glycosphingolipid metabolism (HP:0004343)2.05784357
101Pointed chin (HP:0000307)2.04936409
102Abnormality of the pericardium (HP:0001697)2.03490937
103Acne (HP:0001061)2.02974143
104Glomerulopathy (HP:0100820)2.02192014
105Apathy (HP:0000741)2.02094748
106Hyperacusis (HP:0010780)2.01277668
107Loss of speech (HP:0002371)2.00758321
108Abnormality of T cell physiology (HP:0011840)1.99960890
109Vertigo (HP:0002321)1.98929726
110Gingivitis (HP:0000230)1.98883597
111Eosinophilia (HP:0001880)1.98875118
112Gastrointestinal stroma tumor (HP:0100723)1.98763606
113Slow saccadic eye movements (HP:0000514)1.98188924
114Thoracic kyphosis (HP:0002942)1.94810233
115Cellulitis (HP:0100658)1.94511360
116Rapidly progressive (HP:0003678)1.92955223
117Vertebral compression fractures (HP:0002953)1.90715594
118Personality changes (HP:0000751)1.89549723
119Visual hallucinations (HP:0002367)1.87787732
120Ulnar bowing (HP:0003031)1.86580272
121Retrobulbar optic neuritis (HP:0100654)1.86427917
122Optic neuritis (HP:0100653)1.86427917
123Abnormality of eosinophils (HP:0001879)1.84981235
124Joint swelling (HP:0001386)1.84747922
125Restrictive lung disease (HP:0002091)1.83318086
126Emphysema (HP:0002097)1.82757776
127Protrusio acetabuli (HP:0003179)1.80676483
128Periodontitis (HP:0000704)1.77738091
129Premature ovarian failure (HP:0008209)1.76213380
130Deep palmar crease (HP:0006191)1.73405433
131Spinal muscular atrophy (HP:0007269)1.72715466
132Bowing of the arm (HP:0006488)1.72391191
133Bowed forearm bones (HP:0003956)1.72391191
134Ankle contracture (HP:0006466)1.71869863
135Ocular albinism (HP:0001107)1.68122885
136Shallow orbits (HP:0000586)1.67955189
137Pelvic girdle muscle weakness (HP:0003749)1.67773090
138Wrist flexion contracture (HP:0001239)1.67609442
139Abnormality of the Achilles tendon (HP:0005109)1.67242221
140Tetraparesis (HP:0002273)1.65596009
141Cortical dysplasia (HP:0002539)1.65495055
142Leukocytosis (HP:0001974)1.64595239
143Broad distal phalanx of finger (HP:0009836)1.64044347
144Cervical subluxation (HP:0003308)1.63140898
145Recurrent viral infections (HP:0004429)1.62908322
146Milia (HP:0001056)1.62317649
147Abnormal neuron morphology (HP:0012757)1.61826170
148Abnormality of the motor neurons (HP:0002450)1.61826170
149Distal lower limb amyotrophy (HP:0008944)1.61325747
150Selective tooth agenesis (HP:0001592)1.60752628
151Osteomyelitis (HP:0002754)1.57906748
152Recurrent skin infections (HP:0001581)1.56930730
153Pulmonary infiltrates (HP:0002113)1.56891650
154Degeneration of anterior horn cells (HP:0002398)1.56703981
155Abnormality of the anterior horn cell (HP:0006802)1.56703981
156Vasculitis (HP:0002633)1.56496260
157Basal cell carcinoma (HP:0002671)1.55342022
158Myokymia (HP:0002411)1.54489363
159Hypergammaglobulinemia (HP:0010702)1.54246229
160Ulnar deviation of the wrist (HP:0003049)1.52870626
161Premature loss of primary teeth (HP:0006323)1.51905188
162Iris hypopigmentation (HP:0007730)1.51802318
163Albinism (HP:0001022)1.51496206
164Bowel diverticulosis (HP:0005222)1.49561203
165Neuronal loss in central nervous system (HP:0002529)1.49368988
166Aortic aneurysm (HP:0004942)1.49263277
167Lower limb amyotrophy (HP:0007210)1.49235706
168Segmental peripheral demyelination/remyelination (HP:0003481)1.48992329

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.01106332
2KSR23.31625240
3TRIB33.02133405
4IRAK42.99374779
5EEF2K2.62355076
6MAP3K132.47484084
7MAP4K12.31977696
8RIPK42.27791784
9PKN22.27417452
10PRPF4B2.17650697
11GRK62.15051117
12CSK2.12843113
13TAOK12.01072334
14ZAP701.96887236
15SCYL21.91882094
16MAPKAPK31.83757019
17BLK1.83533389
18ERN11.81097718
19LATS21.79614484
20TESK21.79262825
21TYK21.77522001
22BTK1.74528304
23NEK21.74393603
24TNK21.73491569
25MAP3K111.64141806
26JAK31.53992855
27TBK11.47009164
28TESK11.46579231
29TTN1.43654485
30ARAF1.34267662
31IRAK31.33594724
32LRRK21.30338363
33SMG11.30264562
34MOS1.28875909
35MAP3K101.28088259
36STK101.25119521
37PRKD31.23097011
38FGFR41.22254546
39ALK1.20488215
40JAK11.19930921
41LYN1.18225333
42RET1.17750472
43PAK61.17096005
44KSR11.16860097
45KIT1.15248499
46MARK21.15188308
47IKBKB1.14869682
48PAK41.10555022
49IRAK21.10294597
50SIK21.09957808
51IKBKE1.09764306
52MAP3K121.09089336
53RAF11.08139849
54EPHB11.06989312
55MAP3K11.06350088
56MAP3K81.04049365
57CDC42BPA1.03021978
58IRAK11.02907540
59MAP3K71.02884171
60PRKD21.02205124
61EPHA21.01821976
62BUB11.00652440
63LIMK10.99552905
64CDK120.99283633
65CSF1R0.98721974
66HCK0.98612513
67MAP2K30.97065925
68MAP3K20.95583927
69MAP3K60.95477471
70RPS6KA40.94820271
71TYRO30.92560017
72ITK0.89263499
73RIPK10.87384714
74FES0.87122937
75TAOK20.86613172
76MAP3K50.85457080
77NTRK10.84386954
78DYRK1B0.83415798
79DAPK20.81695337
80RPS6KC10.78700125
81RPS6KL10.78700125
82MAP3K140.75660661
83NEK10.74765935
84HIPK20.74435800
85TXK0.74328231
86BMX0.74133802
87RPS6KA60.74056940
88ICK0.73466807
89DAPK10.71580014
90MAP2K60.70878794
91SIK30.69909645
92MAPK120.69318276
93MAP2K40.69086758
94CAMKK10.68727784
95SYK0.67928574
96MAP3K30.67318174
97MAPK70.66098087
98STK380.64673198
99DAPK30.63892362
100RPS6KB20.61135057
101PDGFRA0.61098672
102TEC0.60525188
103PTK20.60198120
104PTK60.59776627
105EPHA30.59414856
106MAP2K20.59269279
107CDK190.56682016
108JAK20.56373693
109YES10.55764653
110STK110.55457608
111FGR0.54347195
112RPS6KA20.52833143
113PTK2B0.51956042
114GRK70.50936392
115MAPK110.50693509
116MTOR0.50151412
117FER0.49920894
118FGFR30.49622461
119PRKCQ0.49544121
120BMPR20.49207755
121PDGFRB0.48803159
122FYN0.48326582
123MATK0.48259253
124CDK40.48038389
125MINK10.47650252
126CDK60.47046546
127ERBB40.46610908
128KDR0.46301647
129PDK10.45037917
130PAK10.44531817
131PRKCH0.43649422
132MAP2K10.43350217
133SIK10.43233598
134LCK0.43051210
135PIM20.41964503
136PIM10.41201691
137TAOK30.40022095
138PDPK10.39394604
139MARK30.37918221
140EGFR0.36964306
141CAMK40.36736386
142WEE10.36734173
143CHUK0.34708828
144AURKA0.33954915
145TTK0.33638812
146BRAF0.32023600

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.22350375
2Graft-versus-host disease_Homo sapiens_hsa053322.01048742
3Allograft rejection_Homo sapiens_hsa053301.98886079
4Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.96181495
5Autoimmune thyroid disease_Homo sapiens_hsa053201.78475229
6VEGF signaling pathway_Homo sapiens_hsa043701.77673230
7Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.73897029
8Leishmaniasis_Homo sapiens_hsa051401.64553422
9Shigellosis_Homo sapiens_hsa051311.62271732
10Osteoclast differentiation_Homo sapiens_hsa043801.55135144
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.50303394
12Chronic myeloid leukemia_Homo sapiens_hsa052201.45682934
13B cell receptor signaling pathway_Homo sapiens_hsa046621.44986705
14mTOR signaling pathway_Homo sapiens_hsa041501.43613560
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.41709350
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.39979773
17Neurotrophin signaling pathway_Homo sapiens_hsa047221.39943263
18Apoptosis_Homo sapiens_hsa042101.33800243
19Type I diabetes mellitus_Homo sapiens_hsa049401.30861525
20Tuberculosis_Homo sapiens_hsa051521.30408004
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29413211
22Pancreatic cancer_Homo sapiens_hsa052121.27955111
23Influenza A_Homo sapiens_hsa051641.25069291
24Acute myeloid leukemia_Homo sapiens_hsa052211.24404330
25Toxoplasmosis_Homo sapiens_hsa051451.22764606
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22406685
27African trypanosomiasis_Homo sapiens_hsa051431.21935393
28TNF signaling pathway_Homo sapiens_hsa046681.20890296
29Lysosome_Homo sapiens_hsa041421.19966136
30Salmonella infection_Homo sapiens_hsa051321.16890817
31T cell receptor signaling pathway_Homo sapiens_hsa046601.16455143
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15340408
33HIF-1 signaling pathway_Homo sapiens_hsa040661.15231169
34Glioma_Homo sapiens_hsa052141.14894810
35Hepatitis B_Homo sapiens_hsa051611.13045570
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12584742
37Measles_Homo sapiens_hsa051621.10617012
38Prolactin signaling pathway_Homo sapiens_hsa049171.10114135
39Non-small cell lung cancer_Homo sapiens_hsa052231.10013557
40Asthma_Homo sapiens_hsa053101.08130822
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07334619
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07296495
43Small cell lung cancer_Homo sapiens_hsa052221.07138674
44Synaptic vesicle cycle_Homo sapiens_hsa047211.05969668
45Pertussis_Homo sapiens_hsa051331.05602602
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.04935218
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04494392
48Central carbon metabolism in cancer_Homo sapiens_hsa052301.03877977
49GnRH signaling pathway_Homo sapiens_hsa049121.03418742
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02121171
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00208023
52Bladder cancer_Homo sapiens_hsa052190.99170218
53Legionellosis_Homo sapiens_hsa051340.98625699
54p53 signaling pathway_Homo sapiens_hsa041150.98572749
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98568066
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97993863
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97940627
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97683541
59Oocyte meiosis_Homo sapiens_hsa041140.97362735
60Epstein-Barr virus infection_Homo sapiens_hsa051690.94914180
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.93861304
62Endocytosis_Homo sapiens_hsa041440.93476089
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.92230075
64Colorectal cancer_Homo sapiens_hsa052100.92097908
65Inositol phosphate metabolism_Homo sapiens_hsa005620.91608313
66Phagosome_Homo sapiens_hsa041450.91032741
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.90799531
68Dorso-ventral axis formation_Homo sapiens_hsa043200.90070709
69Chemokine signaling pathway_Homo sapiens_hsa040620.88772411
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87727547
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87274424
72Malaria_Homo sapiens_hsa051440.87123376
73Viral myocarditis_Homo sapiens_hsa054160.86304359
74Viral carcinogenesis_Homo sapiens_hsa052030.86215637
75Renal cell carcinoma_Homo sapiens_hsa052110.85890867
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.85160017
77RNA transport_Homo sapiens_hsa030130.83467194
78Antigen processing and presentation_Homo sapiens_hsa046120.82369119
79Platelet activation_Homo sapiens_hsa046110.81837473
80Primary immunodeficiency_Homo sapiens_hsa053400.81197706
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80012184
82Proteoglycans in cancer_Homo sapiens_hsa052050.79497645
83MicroRNAs in cancer_Homo sapiens_hsa052060.79231433
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78639189
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78167448
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.77590486
87Endometrial cancer_Homo sapiens_hsa052130.77458450
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76636964
89Amoebiasis_Homo sapiens_hsa051460.76168539
90Cell cycle_Homo sapiens_hsa041100.75546691
91Other glycan degradation_Homo sapiens_hsa005110.75515878
92Herpes simplex infection_Homo sapiens_hsa051680.74725724
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74381201
94HTLV-I infection_Homo sapiens_hsa051660.72703607
95Hematopoietic cell lineage_Homo sapiens_hsa046400.72478852
96Hepatitis C_Homo sapiens_hsa051600.71598746
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70378614
98Estrogen signaling pathway_Homo sapiens_hsa049150.69749084
99Type II diabetes mellitus_Homo sapiens_hsa049300.67743082
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67384571
101ErbB signaling pathway_Homo sapiens_hsa040120.66788565
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66574967
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66139166
104FoxO signaling pathway_Homo sapiens_hsa040680.66089573
105Choline metabolism in cancer_Homo sapiens_hsa052310.64565917
106Thyroid cancer_Homo sapiens_hsa052160.62324026
107MAPK signaling pathway_Homo sapiens_hsa040100.62274228
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61696772
109Notch signaling pathway_Homo sapiens_hsa043300.61223961
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60559027
111Rap1 signaling pathway_Homo sapiens_hsa040150.59937685
112Focal adhesion_Homo sapiens_hsa045100.57043340
113Insulin signaling pathway_Homo sapiens_hsa049100.56947791
114Rheumatoid arthritis_Homo sapiens_hsa053230.55670397
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55479118
116Insulin resistance_Homo sapiens_hsa049310.54232161
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52237584
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47475952
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46468185
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44018405
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39235617
122* Glycerophospholipid metabolism_Homo sapiens_hsa005640.34635970
123Prostate cancer_Homo sapiens_hsa052150.33627241

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