PHACTR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of relaxation of muscle (GO:1901077)5.83277826
2negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.79415141
3cardiac myofibril assembly (GO:0055003)5.19186634
4negative regulation of striated muscle cell apoptotic process (GO:0010664)4.79141311
5actin-myosin filament sliding (GO:0033275)4.73915547
6muscle filament sliding (GO:0030049)4.73915547
7keratinocyte development (GO:0003334)4.70803800
8cardiac muscle tissue morphogenesis (GO:0055008)4.66374005
9definitive hemopoiesis (GO:0060216)4.64782652
10myofibril assembly (GO:0030239)4.58772849
11lactate metabolic process (GO:0006089)4.52375262
12positive regulation of protein autophosphorylation (GO:0031954)4.48858448
13ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.45787112
14heart contraction (GO:0060047)4.31546146
15heart process (GO:0003015)4.31546146
16muscle tissue morphogenesis (GO:0060415)4.21444488
17actin-mediated cell contraction (GO:0070252)4.20278033
18proteasome assembly (GO:0043248)4.17243093
19sarcomere organization (GO:0045214)4.16322043
20regulation of glucokinase activity (GO:0033131)4.09981359
21regulation of hexokinase activity (GO:1903299)4.09981359
22cardiac muscle contraction (GO:0060048)4.07643778
23positive regulation of glycoprotein biosynthetic process (GO:0010560)3.96833931
24DNA double-strand break processing (GO:0000729)3.83371440
25regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.83169036
26regulation of actin filament-based movement (GO:1903115)3.67636326
27negative regulation of dendrite morphogenesis (GO:0050774)3.63100599
28regulation of mesoderm development (GO:2000380)3.61546833
29regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.59884992
30cardiac muscle hypertrophy (GO:0003300)3.59375875
31regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.57468989
32atrial cardiac muscle cell action potential (GO:0086014)3.55681166
33female gonad development (GO:0008585)3.54750702
34adult heart development (GO:0007512)3.54375968
35regulation of protein autophosphorylation (GO:0031952)3.49597644
36positive regulation of glycoprotein metabolic process (GO:1903020)3.49514320
37regulation of Rac protein signal transduction (GO:0035020)3.48509998
38negative regulation of protein autophosphorylation (GO:0031953)3.43189466
39negative regulation of homotypic cell-cell adhesion (GO:0034111)3.41404667
40negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.41139105
41anterior/posterior axis specification, embryo (GO:0008595)3.40893506
42striated muscle hypertrophy (GO:0014897)3.39993051
43negative regulation of DNA-dependent DNA replication (GO:2000104)3.38443811
44regulation of cell communication by electrical coupling (GO:0010649)3.38319701
45cardiac muscle cell development (GO:0055013)3.29009765
46regulation of sulfur metabolic process (GO:0042762)3.27989491
47regulation of striated muscle contraction (GO:0006942)3.27686993
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.27015981
49glomerulus development (GO:0032835)3.25948578
50regulation of striated muscle cell apoptotic process (GO:0010662)3.23807088
51positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.23717287
52dorsal/ventral axis specification (GO:0009950)3.23583168
53negative regulation of activin receptor signaling pathway (GO:0032926)3.23551344
54neurofilament cytoskeleton organization (GO:0060052)3.22084234
55somite rostral/caudal axis specification (GO:0032525)3.21374092
56cardiac cell development (GO:0055006)3.20511405
57branched-chain amino acid catabolic process (GO:0009083)3.20410471
58regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.20240374
59muscle hypertrophy (GO:0014896)3.19766906
60peripheral nervous system neuron development (GO:0048935)3.19664203
61regulation of sarcomere organization (GO:0060297)3.19289764
62actomyosin structure organization (GO:0031032)3.18684049
63embryonic foregut morphogenesis (GO:0048617)3.17725108
64actin filament-based movement (GO:0030048)3.17286934
65glomerular basement membrane development (GO:0032836)3.17082796
66respiratory chain complex IV assembly (GO:0008535)3.16400609
67replication fork processing (GO:0031297)3.15329821
68atrial septum morphogenesis (GO:0060413)3.14108277
69zinc ion transport (GO:0006829)3.13881690
70striated muscle contraction (GO:0006941)3.11266392
71regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.11208584
72endoderm formation (GO:0001706)3.10925724
73neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.07581980
74ventricular trabecula myocardium morphogenesis (GO:0003222)3.07569307
75positive regulation of cardiac muscle tissue development (GO:0055025)3.07300729
76positive regulation of cardiac muscle cell differentiation (GO:2000727)3.04654497
77platelet dense granule organization (GO:0060155)3.04169369
78regulation of centriole replication (GO:0046599)3.02433858
79chromatin remodeling at centromere (GO:0031055)3.01005279
80positive regulation of cardiac muscle cell proliferation (GO:0060045)3.00582588
81protein neddylation (GO:0045116)2.99976770
82mesonephros development (GO:0001823)2.99829127
83somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.99441814
84isotype switching (GO:0045190)2.99441814
85somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.99441814
86negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.99105160
87signal peptide processing (GO:0006465)2.98966907
88heart trabecula formation (GO:0060347)2.98449450
89relaxation of smooth muscle (GO:0044557)2.97835336
90genitalia morphogenesis (GO:0035112)2.96881932
91UDP-N-acetylglucosamine metabolic process (GO:0006047)2.96837742
92CENP-A containing nucleosome assembly (GO:0034080)2.96395446
93sequestering of extracellular ligand from receptor (GO:0035581)2.95673674
94cardiac chamber formation (GO:0003207)2.95297579
95histone exchange (GO:0043486)2.94354923
96positive regulation of vasculogenesis (GO:2001214)2.93002231
97regulation of skeletal muscle contraction (GO:0014819)2.92605908
98vascular endothelial growth factor signaling pathway (GO:0038084)2.92468370
99transcytosis (GO:0045056)2.90965444
100cullin deneddylation (GO:0010388)2.90443343
101histamine secretion (GO:0001821)2.88758322
102regulation of cardiac muscle cell apoptotic process (GO:0010665)2.88631846
103regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.88432119
104regulation of cardiac muscle contraction (GO:0055117)2.88287924
105regulation of acyl-CoA biosynthetic process (GO:0050812)2.87684875
106facial nerve structural organization (GO:0021612)2.87552159
107endocardial cushion morphogenesis (GO:0003203)2.87345730
108positive regulation of cardiac muscle tissue growth (GO:0055023)2.87259266
109regulation of the force of heart contraction (GO:0002026)2.87240424
110signal transduction involved in regulation of gene expression (GO:0023019)2.86806982
111relaxation of cardiac muscle (GO:0055119)2.86726399
112negative regulation of myotube differentiation (GO:0010832)2.86540431
113negative regulation of axon extension involved in axon guidance (GO:0048843)2.86376064
114response to pheromone (GO:0019236)2.85845772
115mesenchyme morphogenesis (GO:0072132)2.84816588
116outflow tract septum morphogenesis (GO:0003148)2.83219228
117bundle of His cell to Purkinje myocyte communication (GO:0086069)2.81747650
118endothelium development (GO:0003158)2.78666106
119venous blood vessel morphogenesis (GO:0048845)2.78166412
120lymphoid progenitor cell differentiation (GO:0002320)2.76101396
121kidney morphogenesis (GO:0060993)2.75942896
122response to X-ray (GO:0010165)2.75655649
123negative regulation of muscle cell apoptotic process (GO:0010656)2.75348091
124nodal signaling pathway (GO:0038092)2.74488026
125water-soluble vitamin biosynthetic process (GO:0042364)2.74146422
126cell proliferation involved in metanephros development (GO:0072203)2.72627046
127RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.72417388
128regulation of pigment cell differentiation (GO:0050932)2.72004521
129regulation of cardiac muscle cell contraction (GO:0086004)2.71682420
130regulation of muscle contraction (GO:0006937)2.71537527
131regulation of vasculogenesis (GO:2001212)2.71140658
132negative regulation of potassium ion transmembrane transport (GO:1901380)2.70201663
133heart trabecula morphogenesis (GO:0061384)2.69486030
134doxorubicin metabolic process (GO:0044598)2.69467718
135daunorubicin metabolic process (GO:0044597)2.69467718
136polyketide metabolic process (GO:0030638)2.69467718
137embryonic axis specification (GO:0000578)2.68866164
138anterior/posterior axis specification (GO:0009948)2.67942748
139regulation of cardioblast differentiation (GO:0051890)2.67933244
140negative regulation of protein localization to cell surface (GO:2000009)2.67783120
141lymph vessel development (GO:0001945)2.67724394
142heart valve formation (GO:0003188)2.67538633
143negative regulation of calcium ion transport into cytosol (GO:0010523)2.66505218
144cell proliferation involved in kidney development (GO:0072111)2.66500146
145Rap protein signal transduction (GO:0032486)2.66217948
146protein deneddylation (GO:0000338)2.66028635
147synapsis (GO:0007129)2.65015353
148cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.63209274
149response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.62862591
150ventricular cardiac muscle cell development (GO:0055015)2.62136497
151negative regulation of skeletal muscle tissue development (GO:0048642)2.61149956
152positive regulation of heart growth (GO:0060421)2.60988655
153heart valve morphogenesis (GO:0003179)2.58014711
154regulation of muscle system process (GO:0090257)2.56280475
155protein K6-linked ubiquitination (GO:0085020)2.55571748
156negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.55147284
157regulation of cofactor metabolic process (GO:0051193)2.54970950
158regulation of coenzyme metabolic process (GO:0051196)2.54970950
159regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.54645011
160protein prenylation (GO:0018342)2.54376582
161prenylation (GO:0097354)2.54376582
162relaxation of muscle (GO:0090075)2.53472195
163peptidyl-cysteine modification (GO:0018198)2.53296958
164regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.53047126
165regulation of mitotic spindle checkpoint (GO:1903504)2.53047126
166L-serine transport (GO:0015825)2.52772638
167heme transport (GO:0015886)2.52352999
168cytochrome complex assembly (GO:0017004)2.52191734
169double-strand break repair via nonhomologous end joining (GO:0006303)2.51880790
170non-recombinational repair (GO:0000726)2.51880790
171trabecula morphogenesis (GO:0061383)2.50987285
172positive regulation of myoblast differentiation (GO:0045663)2.50500962
173regulation of nuclear cell cycle DNA replication (GO:0033262)2.45908208
174organ formation (GO:0048645)2.43308265
175mitotic sister chromatid cohesion (GO:0007064)2.41761536
176cell migration involved in gastrulation (GO:0042074)2.41755032
177parental behavior (GO:0060746)2.41635135
178DNA replication checkpoint (GO:0000076)2.41601569
179mitotic G2/M transition checkpoint (GO:0044818)2.41013464
180response to BMP (GO:0071772)2.39797232
181cellular response to BMP stimulus (GO:0071773)2.39797232
182pericardium development (GO:0060039)2.37447140
183pancreas development (GO:0031016)2.36169532
184phospholipid homeostasis (GO:0055091)2.35728456
185DNA replication-dependent nucleosome assembly (GO:0006335)2.35510772
186DNA replication-dependent nucleosome organization (GO:0034723)2.35510772
187gastrulation (GO:0007369)2.35091508
188primitive streak formation (GO:0090009)2.34503586
189negative regulation of hormone biosynthetic process (GO:0032353)2.34482667
190branched-chain amino acid metabolic process (GO:0009081)2.34277338
191negative regulation of neurological system process (GO:0031645)2.31315268
192regulation of type B pancreatic cell apoptotic process (GO:2000674)2.31094166
193Leydig cell differentiation (GO:0033327)2.28646860
194negative regulation of translation, ncRNA-mediated (GO:0040033)2.28454061
195regulation of translation, ncRNA-mediated (GO:0045974)2.28454061
196negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.28454061
197negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.28418730
198regulation of meiosis I (GO:0060631)2.27810678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.58695702
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.34465460
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.24851455
4* EP300_21415370_ChIP-Seq_HL-1_Mouse3.12483109
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.09864884
6GATA1_22025678_ChIP-Seq_K562_Human2.87996729
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.67491501
8* CDX2_19796622_ChIP-Seq_MESCs_Mouse2.65800851
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.60650149
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.53979609
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.53466840
12GATA2_21666600_ChIP-Seq_HMVEC_Human2.44570303
13VDR_22108803_ChIP-Seq_LS180_Human2.42315674
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.36005470
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.33772667
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.33253024
17EWS_26573619_Chip-Seq_HEK293_Human2.29176637
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26074650
19SCL_19346495_ChIP-Seq_HPC-7_Human2.19034922
20ELK1_19687146_ChIP-ChIP_HELA_Human2.14076586
21FUS_26573619_Chip-Seq_HEK293_Human2.14054373
22ZNF274_21170338_ChIP-Seq_K562_Hela2.13735036
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07490337
24PCGF2_27294783_Chip-Seq_ESCs_Mouse2.06242586
25RUNX_20019798_ChIP-Seq_JUKART_Human1.99228567
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.92307054
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88905143
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.86540634
29IGF1R_20145208_ChIP-Seq_DFB_Human1.83432028
30* EZH2_27294783_Chip-Seq_NPCs_Mouse1.78838424
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.75835260
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.73952378
33ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.70029830
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.65415471
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.64781404
36* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64611023
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.64272456
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.62811659
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.61280611
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.60672933
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60439326
42* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59847586
43VDR_24787735_ChIP-Seq_THP-1_Human1.59303322
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57915244
45* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55748440
46TAF15_26573619_Chip-Seq_HEK293_Human1.55579853
47FOXM1_26456572_ChIP-Seq_MCF-7_Human1.52553703
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52533040
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52208405
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52092415
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51406583
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.50688594
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50209519
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.49321245
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49162107
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48846691
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48628402
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47856338
59EST1_17652178_ChIP-ChIP_JURKAT_Human1.47303756
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.47101801
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.47101801
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46012277
63CDX2_22108803_ChIP-Seq_LS180_Human1.45214510
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43744217
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43447982
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.42087898
67TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.41297447
68NANOG_19829295_ChIP-Seq_ESCs_Human1.40976393
69SOX2_19829295_ChIP-Seq_ESCs_Human1.40976393
70RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40197230
71* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.39990415
72CJUN_26792858_Chip-Seq_BT549_Human1.39429152
73MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.39209211
74TCF4_22108803_ChIP-Seq_LS180_Human1.38807846
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38305737
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38117457
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37536540
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.37323238
79SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37305847
80GBX2_23144817_ChIP-Seq_PC3_Human1.37208292
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37041926
82NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36753571
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36753571
84* CRX_20693478_ChIP-Seq_RETINA_Mouse1.35870992
85ER_23166858_ChIP-Seq_MCF-7_Human1.35140063
86E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34602081
87AR_25329375_ChIP-Seq_VCAP_Human1.34086382
88* TBX20_22328084_ChIP-Seq_HEART_Mouse1.33465691
89* TBX20_22080862_ChIP-Seq_HEART_Mouse1.33465691
90TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33445748
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32822245
92BRD4_25478319_ChIP-Seq_HGPS_Human1.30740528
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30348542
94CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29139506
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27707630
96PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27292444
97ESR1_21235772_ChIP-Seq_MCF-7_Human1.27110690
98SMAD4_21741376_ChIP-Seq_EPCs_Human1.26567681
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26433974
100EZH2_22144423_ChIP-Seq_EOC_Human1.26162924
101IRF8_27001747_Chip-Seq_BMDM_Mouse1.25689673
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24944950
103CBP_20019798_ChIP-Seq_JUKART_Human1.24944950
104PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24442809
105SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24080818
106STAT3_23295773_ChIP-Seq_U87_Human1.23896350
107STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23606461
108SPI1_23127762_ChIP-Seq_K562_Human1.23402148
109ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22841757
110EZH2_27304074_Chip-Seq_ESCs_Mouse1.22400914
111* SMAD3_21741376_ChIP-Seq_HESCs_Human1.22266945
112P53_22387025_ChIP-Seq_ESCs_Mouse1.21817511
113CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19962906
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19428103
115TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19402366
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19052219
117MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17652155
118BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17575688
119CMYC_18555785_Chip-Seq_ESCs_Mouse1.17416425
120SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16245772
121NANOG_16153702_ChIP-ChIP_HESCs_Human1.16002760
122* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15345589
123* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.15138681
124TP53_18474530_ChIP-ChIP_U2OS_Human1.15120593
125HTT_18923047_ChIP-ChIP_STHdh_Human1.14460795
126* FLI1_21867929_ChIP-Seq_TH2_Mouse1.13305187
127SMAD4_21799915_ChIP-Seq_A2780_Human1.12582780
128NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12146458
129P300_18555785_Chip-Seq_ESCs_Mouse1.11515496
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11055356
131TCF4_23295773_ChIP-Seq_U87_Human1.10562376
132BCAT_22108803_ChIP-Seq_LS180_Human1.10412018
133PIAS1_25552417_ChIP-Seq_VCAP_Human1.10019712
134* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09974753
135ESR2_21235772_ChIP-Seq_MCF-7_Human1.09466960
136* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.09455845
137AR_21909140_ChIP-Seq_LNCAP_Human1.09261572
138MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08501973
139SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08446640
140* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08279500
141MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08056368
142STAT3_18555785_Chip-Seq_ESCs_Mouse1.07814840
143* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07451779
144* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06647846
145Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06049010
146TP63_17297297_ChIP-ChIP_HaCaT_Human1.05875280
147* P300_19829295_ChIP-Seq_ESCs_Human1.05248882
148RNF2_27304074_Chip-Seq_ESCs_Mouse1.04919125
149AHR_22903824_ChIP-Seq_MCF-7_Human1.03507421
150EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03356722
151RUNX2_22187159_ChIP-Seq_PCA_Human1.03282432
152FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02164347
153AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01963455
154ISL1_27105846_Chip-Seq_CPCs_Mouse1.01902477
155RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01624740
156* SOX2_20726797_ChIP-Seq_SW620_Human1.00897389
157LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00249281
158NOTCH1_21737748_ChIP-Seq_TLL_Human0.98080186
159SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97967707
160CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97066576
161RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94904277
162* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91278585
163STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90968140
164CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90932421
165BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90868161
166POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90509576
167E2F1_18555785_Chip-Seq_ESCs_Mouse0.90381431
168SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90175167
169* SMAD3_21741376_ChIP-Seq_EPCs_Human0.88975906
170ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88939841
171GATA2_19941826_ChIP-Seq_K562_Human0.88674756
172NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88093627
173TCF4_18268006_ChIP-ChIP_LS174T_Human0.87524772
174GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87173486
175NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87006138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis5.09795656
2MP0004084_abnormal_cardiac_muscle3.99777822
3MP0002254_reproductive_system_inflammat3.98744603
4MP0003890_abnormal_embryonic-extraembry3.38537667
5MP0003828_pulmonary_edema3.28406671
6MP0000749_muscle_degeneration3.13636209
7MP0010368_abnormal_lymphatic_system3.04652824
8MP0003122_maternal_imprinting2.81343661
9MP0001879_abnormal_lymphatic_vessel2.78961085
10MP0004036_abnormal_muscle_relaxation2.74743706
11MP0002102_abnormal_ear_morphology2.62630707
12MP0002972_abnormal_cardiac_muscle2.61629175
13MP0005409_darkened_coat_color2.60651051
14MP0010234_abnormal_vibrissa_follicle2.58828366
15MP0000516_abnormal_urinary_system2.57429740
16MP0005367_renal/urinary_system_phenotyp2.57429740
17MP0008775_abnormal_heart_ventricle2.55347897
18MP0004147_increased_porphyrin_level2.52450049
19MP0004510_myositis2.43396286
20MP0004215_abnormal_myocardial_fiber2.42896901
21MP0009379_abnormal_foot_pigmentation2.42720288
22MP0000751_myopathy2.40445745
23MP0004272_abnormal_basement_membrane2.39993390
24MP0003279_aneurysm2.36888285
25MP0006138_congestive_heart_failure2.30978111
26MP0008877_abnormal_DNA_methylation2.26916446
27MP0001544_abnormal_cardiovascular_syste2.14892758
28MP0005385_cardiovascular_system_phenoty2.14892758
29MP0000372_irregular_coat_pigmentation2.10014468
30MP0010630_abnormal_cardiac_muscle2.07129781
31MP0010352_gastrointestinal_tract_polyps1.94171544
32MP0009780_abnormal_chondrocyte_physiolo1.93216599
33MP0005330_cardiomyopathy1.90994732
34MP0002735_abnormal_chemical_nociception1.89088198
35MP0004484_altered_response_of1.86904893
36MP0003567_abnormal_fetal_cardiomyocyte1.86717711
37MP0008004_abnormal_stomach_pH1.83394566
38MP0009697_abnormal_copulation1.82954316
39MP0005620_abnormal_muscle_contractility1.75020845
40MP0003646_muscle_fatigue1.74118479
41MP0001188_hyperpigmentation1.74101856
42MP0004145_abnormal_muscle_electrophysio1.69084087
43MP0005174_abnormal_tail_pigmentation1.66992181
44MP0004087_abnormal_muscle_fiber1.66044925
45MP0003941_abnormal_skin_development1.65872028
46MP0001984_abnormal_olfaction1.64934734
47MP0002127_abnormal_cardiovascular_syste1.59472156
48MP0000767_abnormal_smooth_muscle1.57199641
49MP0003119_abnormal_digestive_system1.56999700
50MP0008057_abnormal_DNA_replication1.54973725
51MP0003786_premature_aging1.54513474
52MP0004085_abnormal_heartbeat1.53341677
53MP0001986_abnormal_taste_sensitivity1.47340731
54MP0003937_abnormal_limbs/digits/tail_de1.47311363
55MP0002938_white_spotting1.47208620
56MP0003943_abnormal_hepatobiliary_system1.46916558
57MP0003283_abnormal_digestive_organ1.46598392
58MP0000015_abnormal_ear_pigmentation1.45750846
59MP0002009_preneoplasia1.43734672
60MP0002837_dystrophic_cardiac_calcinosis1.42589275
61MP0002106_abnormal_muscle_physiology1.40905637
62MP0000343_altered_response_to1.35423113
63MP0010678_abnormal_skin_adnexa1.34754332
64MP0006072_abnormal_retinal_apoptosis1.32019309
65MP0003566_abnormal_cell_adhesion1.30346515
66MP0004808_abnormal_hematopoietic_stem1.30078360
67MP0006276_abnormal_autonomic_nervous1.28236307
68MP0002168_other_aberrant_phenotype1.27307990
69MP0003121_genomic_imprinting1.26410179
70MP0000427_abnormal_hair_cycle1.25978221
71MP0008058_abnormal_DNA_repair1.25757859
72MP0003137_abnormal_impulse_conducting1.23578926
73MP0001485_abnormal_pinna_reflex1.23059909
74MP0002295_abnormal_pulmonary_circulatio1.21702563
75MP0005369_muscle_phenotype1.19603366
76MP0000639_abnormal_adrenal_gland1.18022040
77MP0003718_maternal_effect1.17662336
78MP0005377_hearing/vestibular/ear_phenot1.16990477
79MP0003878_abnormal_ear_physiology1.16990477
80MP0005084_abnormal_gallbladder_morpholo1.16715018
81MP0002128_abnormal_blood_circulation1.16391467
82MP0005395_other_phenotype1.16181543
83MP0002396_abnormal_hematopoietic_system1.15944356
84MP0005167_abnormal_blood-brain_barrier1.13362479
85MP0010094_abnormal_chromosome_stability1.12392535
86MP0001661_extended_life_span1.10988514
87MP0001835_abnormal_antigen_presentation1.10675458
88MP0004957_abnormal_blastocyst_morpholog1.09693727
89MP0003724_increased_susceptibility_to1.09615363
90MP0002166_altered_tumor_susceptibility1.09554519
91MP0002148_abnormal_hypersensitivity_rea1.08892948
92MP0000647_abnormal_sebaceous_gland1.07516974
93MP0005253_abnormal_eye_physiology1.07339782
94MP0004133_heterotaxia1.06599578
95MP0003787_abnormal_imprinting1.05340961
96MP0000266_abnormal_heart_morphology1.04154502
97MP0009785_altered_susceptibility_to1.03848530
98MP0002090_abnormal_vision1.03487699
99MP0005187_abnormal_penis_morphology1.03036967
100MP0005551_abnormal_eye_electrophysiolog1.01465323
101MP0001293_anophthalmia1.01216807
102MP0009278_abnormal_bone_marrow1.00869984
103MP0005220_abnormal_exocrine_pancreas0.99365482
104MP0005275_abnormal_skin_tensile0.98785380
105MP0003385_abnormal_body_wall0.98598078
106MP0001958_emphysema0.95842423
107MP0003942_abnormal_urinary_system0.93666116
108MP0009250_abnormal_appendicular_skeleto0.93601577
109MP0005075_abnormal_melanosome_morpholog0.92949449
110MP0008438_abnormal_cutaneous_collagen0.91892918
111MP0001270_distended_abdomen0.91883716
112MP0005595_abnormal_vascular_smooth0.91741567
113MP0000759_abnormal_skeletal_muscle0.91488591
114MP0005171_absent_coat_pigmentation0.90745819
115MP0002084_abnormal_developmental_patter0.90631163
116MP0000230_abnormal_systemic_arterial0.90430852
117MP0010030_abnormal_orbit_morphology0.89723816
118MP0005165_increased_susceptibility_to0.89481361
119MP0002933_joint_inflammation0.89105869
120MP0005379_endocrine/exocrine_gland_phen0.88698618
121MP0006054_spinal_hemorrhage0.88591911
122MP0005451_abnormal_body_composition0.88447830
123MP0000383_abnormal_hair_follicle0.87974266
124MP0001853_heart_inflammation0.87169140
125MP0003221_abnormal_cardiomyocyte_apopto0.86954048
126MP0002925_abnormal_cardiovascular_devel0.85914224
127MP0002282_abnormal_trachea_morphology0.83844481
128MP0002233_abnormal_nose_morphology0.83448023
129MP0000681_abnormal_thyroid_gland0.83173087
130MP0003950_abnormal_plasma_membrane0.82810492
131MP0002638_abnormal_pupillary_reflex0.82151904
132MP0005397_hematopoietic_system_phenotyp0.82074671
133MP0001545_abnormal_hematopoietic_system0.82074671
134MP0002095_abnormal_skin_pigmentation0.81988273
135MP0003186_abnormal_redox_activity0.79522282
136MP0002163_abnormal_gland_morphology0.79499077
137MP0005671_abnormal_response_to0.79312259
138MP0004858_abnormal_nervous_system0.78619484
139MP0005388_respiratory_system_phenotype0.78333588
140MP0002133_abnormal_respiratory_system0.78333588
141MP0001915_intracranial_hemorrhage0.77595868
142MP0002332_abnormal_exercise_endurance0.76609017
143MP0002088_abnormal_embryonic_growth/wei0.76018832
144MP0002277_abnormal_respiratory_mucosa0.76017267
145MP0005503_abnormal_tendon_morphology0.75541076
146MP0002006_tumorigenesis0.74940129
147MP0001119_abnormal_female_reproductive0.74732476
148MP0001614_abnormal_blood_vessel0.74673014
149MP0003315_abnormal_perineum_morphology0.72888002
150MP0001286_abnormal_eye_development0.72799183
151MP0003984_embryonic_growth_retardation0.72734832
152MP0005380_embryogenesis_phenotype0.72602715
153MP0001672_abnormal_embryogenesis/_devel0.72602715
154MP0002751_abnormal_autonomic_nervous0.71877410
155MP0009384_cardiac_valve_regurgitation0.71513664
156MP0001175_abnormal_lung_morphology0.71299940
157MP0008995_early_reproductive_senescence0.69310668
158MP0004883_abnormal_blood_vessel0.68745802
159MP0000566_synostosis0.67172149
160MP0000465_gastrointestinal_hemorrhage0.66842879
161MP0005248_abnormal_Harderian_gland0.66519418
162MP0001299_abnormal_eye_distance/0.66084145
163MP0001666_abnormal_nutrient_absorption0.65304889
164MP0001324_abnormal_eye_pigmentation0.65179597
165MP0006292_abnormal_olfactory_placode0.65103693
166MP0010307_abnormal_tumor_latency0.64671254
167MP0008007_abnormal_cellular_replicative0.62002439
168MP0002160_abnormal_reproductive_system0.61427346
169MP0001697_abnormal_embryo_size0.60201349

Predicted human phenotypes

RankGene SetZ-score
1Atrial fibrillation (HP:0005110)4.78443698
2Sudden death (HP:0001699)4.77212312
3Abnormality of the left ventricular outflow tract (HP:0011103)4.52188823
4Subaortic stenosis (HP:0001682)4.52188823
5Calf muscle hypertrophy (HP:0008981)4.47160456
6Primary atrial arrhythmia (HP:0001692)4.40922681
7Supraventricular tachycardia (HP:0004755)4.25457808
8Lipoatrophy (HP:0100578)4.23570295
9Supraventricular arrhythmia (HP:0005115)4.19369969
10Hypoglycemic seizures (HP:0002173)3.87154806
11Ventricular tachycardia (HP:0004756)3.86046577
12Hyperinsulinemic hypoglycemia (HP:0000825)3.78608785
13Muscle hypertrophy of the lower extremities (HP:0008968)3.78190607
14Exercise-induced muscle cramps (HP:0003710)3.75241265
15Hypothermia (HP:0002045)3.67177283
16Abnormal pancreas size (HP:0012094)3.62591024
17Ulnar claw (HP:0001178)3.47283670
18Pulmonary artery stenosis (HP:0004415)3.44502109
19Abnormality of the calf musculature (HP:0001430)3.36530265
20Hypoglycemic coma (HP:0001325)3.27570667
21Metaphyseal dysplasia (HP:0100255)3.26507614
22Dilated cardiomyopathy (HP:0001644)3.26495069
23Prolonged QT interval (HP:0001657)3.21656886
24Steppage gait (HP:0003376)3.16400294
25Methylmalonic acidemia (HP:0002912)3.08945537
26Pancreatic islet-cell hyperplasia (HP:0004510)3.07383119
27Distal lower limb muscle weakness (HP:0009053)3.00845918
28Hyporeflexia of lower limbs (HP:0002600)3.00106185
29Midline defect of the nose (HP:0004122)2.99829285
30Disproportionate short-trunk short stature (HP:0003521)2.93568931
31Exercise-induced myalgia (HP:0003738)2.90960774
32Hematochezia (HP:0002573)2.89049586
33Intestinal atresia (HP:0011100)2.85309256
34Syncope (HP:0001279)2.80571457
35Abnormality of methionine metabolism (HP:0010901)2.75763116
36Neoplasm of the adrenal cortex (HP:0100641)2.75623455
37Hypoplastic left heart (HP:0004383)2.75128126
38Aqueductal stenosis (HP:0002410)2.74839558
39Neoplasm of the adrenal gland (HP:0100631)2.60193099
40Hyperglycemia (HP:0003074)2.59917322
41Abnormality of aspartate family amino acid metabolism (HP:0010899)2.56588122
42Abnormality of the pancreatic islet cells (HP:0006476)2.53468132
43Abnormality of endocrine pancreas physiology (HP:0012093)2.53468132
44EMG: myopathic abnormalities (HP:0003458)2.52520285
45Abnormality of the right ventricle (HP:0001707)2.52088909
46Colon cancer (HP:0003003)2.47780312
47Abnormality of vitamin B metabolism (HP:0004340)2.43054657
48Bifid tongue (HP:0010297)2.41830589
49Symptomatic seizures (HP:0011145)2.38995120
50Cardiovascular calcification (HP:0011915)2.38748705
51Vascular calcification (HP:0004934)2.37927786
52Recurrent abscess formation (HP:0002722)2.37837224
53Glioma (HP:0009733)2.37503710
54Syringomyelia (HP:0003396)2.35884413
55Spinal cord lesions (HP:0100561)2.35884413
56Ependymoma (HP:0002888)2.32062515
57Hypoplasia of the fovea (HP:0007750)2.31196834
58Aplasia/Hypoplasia of the fovea (HP:0008060)2.31196834
59Abnormality of the nasolacrimal system (HP:0000614)2.29346588
60Facial diplegia (HP:0001349)2.29094128
61Intrahepatic cholestasis (HP:0001406)2.28799579
62Aplasia cutis congenita (HP:0001057)2.26785114
63Breast carcinoma (HP:0003002)2.26473949
64Palpitations (HP:0001962)2.26388247
65Abnormality of the parietal bone (HP:0002696)2.25891389
66Broad metatarsal (HP:0001783)2.25643994
67Methylmalonic aciduria (HP:0012120)2.24699295
68Abnormal EKG (HP:0003115)2.24608554
69Abnormality of the lacrimal duct (HP:0011481)2.24145453
70Abnormality of chromosome stability (HP:0003220)2.22490828
71Bradycardia (HP:0001662)2.22112238
72Neonatal hypoglycemia (HP:0001998)2.21538657
73Myocardial infarction (HP:0001658)2.19835156
74Areflexia of lower limbs (HP:0002522)2.19384537
75Subacute progressive viral hepatitis (HP:0006572)2.17260445
76Double outlet right ventricle (HP:0001719)2.16893578
77Congenital malformation of the right heart (HP:0011723)2.16893578
78Abnormality of the astrocytes (HP:0100707)2.16204640
79Astrocytoma (HP:0009592)2.16204640
80Hypoalphalipoproteinemia (HP:0003233)2.15995172
81Abnormality of the fovea (HP:0000493)2.15783508
82Abnormal umbilical cord blood vessels (HP:0011403)2.14366596
83Single umbilical artery (HP:0001195)2.14366596
84Abnormality of the fetal cardiovascular system (HP:0010948)2.14366596
85Volvulus (HP:0002580)2.14332200
86Patent foramen ovale (HP:0001655)2.13884126
87Myotonia (HP:0002486)2.13631826
88Pancreatic cysts (HP:0001737)2.12562805
89Abnormality of the parathyroid morphology (HP:0011766)2.11750894
90Abnormality of the vitamin B12 metabolism (HP:0004341)2.10293293
91Ventricular arrhythmia (HP:0004308)2.10174486
92Gonadal dysgenesis (HP:0000133)2.10151236
93Hypophosphatemic rickets (HP:0004912)2.09572119
94Sensory axonal neuropathy (HP:0003390)2.09256941
95Asymmetry of the thorax (HP:0001555)2.08931710
96Rhabdomyosarcoma (HP:0002859)2.06986834
97Aplasia/Hypoplasia of the tibia (HP:0005772)2.05202367
98Patchy hypopigmentation of hair (HP:0011365)2.03588881
99Prominent metopic ridge (HP:0005487)2.02497220
100Hypoplastic heart (HP:0001961)2.02346656
101Thyroiditis (HP:0100646)2.01813394
102Absent eyebrow (HP:0002223)2.01674227
103Abnormal lung lobation (HP:0002101)2.00922983
104Asymmetric septal hypertrophy (HP:0001670)2.00739111
105Short tibia (HP:0005736)2.00468775
106Hamartoma of the eye (HP:0010568)2.00349876
107Tongue fasciculations (HP:0001308)1.99666955
108White forelock (HP:0002211)1.99638742
109Mediastinal lymphadenopathy (HP:0100721)1.99253909
110Right ventricular cardiomyopathy (HP:0011663)1.98502816
111Aplasia/Hypoplasia of the uvula (HP:0010293)1.98073369
112Depressed nasal tip (HP:0000437)1.98064459
113Abnormality of the columella (HP:0009929)1.97998708
114Acute myeloid leukemia (HP:0004808)1.97005332
115Posterior subcapsular cataract (HP:0007787)1.96064985
116Mesangial abnormality (HP:0001966)1.95290522
117Heart block (HP:0012722)1.95046469
118Anal stenosis (HP:0002025)1.94711803
119Progressive macrocephaly (HP:0004481)1.94358970
120Hypoplastic pelvis (HP:0008839)1.93116904
121Pancreatic fibrosis (HP:0100732)1.92109300
122Viral hepatitis (HP:0006562)1.92055598
123Ovarian neoplasm (HP:0100615)1.91203145
124Abnormality of the foot musculature (HP:0001436)1.90813516
125Nephronophthisis (HP:0000090)1.90684822
126Short hallux (HP:0010109)1.90232699
127Hypolipoproteinemia (HP:0010981)1.90115772
128Abnormality of midbrain morphology (HP:0002418)1.89424873
129Molar tooth sign on MRI (HP:0002419)1.89424873
130Adrenal hypoplasia (HP:0000835)1.89184205
131Mesomelia (HP:0003027)1.89139849
132Ventricular fibrillation (HP:0001663)1.88940211
133Renal cortical cysts (HP:0000803)1.88353659
134Hypomagnesemia (HP:0002917)1.88286997
135Meckel diverticulum (HP:0002245)1.88011444
136Nonprogressive disorder (HP:0003680)1.87556875
137Preauricular pit (HP:0004467)1.87465146
138Periauricular skin pits (HP:0100277)1.87465146
139Myoglobinuria (HP:0002913)1.86231233
140Abnormality of the nasal septum (HP:0000419)1.84816097
141Abnormality of the labia minora (HP:0012880)1.83766993
142Short 4th metacarpal (HP:0010044)1.83743276
143Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83743276
144Eczematoid dermatitis (HP:0000976)1.83036017
145Diastasis recti (HP:0001540)1.82277218
146Meningioma (HP:0002858)1.82154528
147Foot dorsiflexor weakness (HP:0009027)1.81566592
148Abnormality of the ileum (HP:0001549)1.80875676
149Aplasia/Hypoplasia of the hallux (HP:0008362)1.80859347
150Cutaneous finger syndactyly (HP:0010554)1.80482519
151Abnormal atrioventricular conduction (HP:0005150)1.80465269
152Ectopic kidney (HP:0000086)1.78580202
153Muscle fiber splitting (HP:0003555)1.78021587
154Acute encephalopathy (HP:0006846)1.77969367
155Prolonged bleeding time (HP:0003010)1.77817958
156Agammaglobulinemia (HP:0004432)1.77787090
157Distal arthrogryposis (HP:0005684)1.76752014
158Abnormal ventriculo-arterial connection (HP:0011563)1.76140591
159Transposition of the great arteries (HP:0001669)1.76140591
160Abnormal connection of the cardiac segments (HP:0011545)1.76140591
161Abnormality of the metopic suture (HP:0005556)1.75819430
162Abnormal hair whorl (HP:0010721)1.75801532
163Abnormality of vitamin metabolism (HP:0100508)1.75681941
164Ketoacidosis (HP:0001993)1.75610722
165Nasolacrimal duct obstruction (HP:0000579)1.75495669
166Genital tract atresia (HP:0001827)1.75324328
167Atrioventricular block (HP:0001678)1.73982484
168Left ventricular hypertrophy (HP:0001712)1.73514620
169Abnormality of the endocardium (HP:0004306)1.73299006
170Reduced antithrombin III activity (HP:0001976)1.72959706
171Abnormality of the renal cortex (HP:0011035)1.72333102
172Chronic otitis media (HP:0000389)1.71961093
173Gonadotropin excess (HP:0000837)1.70879572
174Abnormality of the duodenum (HP:0002246)1.70537909
175Barrel-shaped chest (HP:0001552)1.70531788
176True hermaphroditism (HP:0010459)1.70265506
177Progressive inability to walk (HP:0002505)1.70075132
178Submucous cleft hard palate (HP:0000176)1.68623330
179Abolished electroretinogram (ERG) (HP:0000550)1.68522919
180Morphological abnormality of the middle ear (HP:0008609)1.68414599
181Aplasia/Hypoplasia of the tongue (HP:0010295)1.68329289
182Muscle fibrillation (HP:0010546)1.68294021
183Nephroblastoma (Wilms tumor) (HP:0002667)1.67849883
184Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66987272
185Septo-optic dysplasia (HP:0100842)1.66672415
186Centrally nucleated skeletal muscle fibers (HP:0003687)1.66587807
187Increased CSF lactate (HP:0002490)1.66218049
188Type I transferrin isoform profile (HP:0003642)1.65041550
189Aplasia/Hypoplasia involving the musculature (HP:0001460)1.64835390
190Ragged-red muscle fibers (HP:0003200)1.64745377
191Vaginal atresia (HP:0000148)1.64719047
192Abnormality of incisor morphology (HP:0011063)1.64525370
193Stenosis of the external auditory canal (HP:0000402)1.64438636
194Large for gestational age (HP:0001520)1.64330632
195IgM deficiency (HP:0002850)1.63724634
196Aortic aneurysm (HP:0004942)1.63350485
197Generalized muscle weakness (HP:0003324)1.62717575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.41237599
2FRK4.26514858
3OBSCN4.03627273
4MYLK3.74584647
5TRIM283.70546224
6MST43.53751418
7MUSK3.30435852
8STK243.14983919
9EIF2AK32.38738933
10TEC2.31822240
11WNK32.15139118
12ZAK2.13920598
13NEK92.02895704
14PLK31.99920442
15TGFBR21.96164808
16TNIK1.91435279
17PLK41.90898286
18ERBB31.88078735
19PIK3CA1.87632704
20TGFBR11.86007205
21GRK11.84837643
22MATK1.83904223
23MAP3K141.77338036
24FLT31.77044317
25IRAK41.73647118
26FGFR21.70968197
27LMTK21.69078073
28PLK21.67799294
29DMPK1.66805811
30BMPR1B1.62575500
31MAP2K31.60574265
32PBK1.58526736
33KIT1.55842527
34MAP4K11.53732224
35TRPM71.51233780
36KDR1.49138552
37TXK1.48461234
38SGK21.47526566
39SIK31.45965992
40EIF2AK11.42226105
41STK31.41592734
42MAP4K21.37278666
43CASK1.35584836
44WEE11.33776473
45BUB11.33487261
46YES11.28208546
47NEK11.26808599
48BCR1.25693341
49NLK1.23103000
50ACVR1B1.22828129
51BTK1.20386470
52CLK11.20321663
53MKNK21.16928336
54GRK71.15928469
55PNCK1.14472701
56EPHA31.14383930
57CSNK1G11.11886392
58ZAP701.11569347
59ERBB41.11283377
60CAMK11.09372570
61PAK31.08941678
62TSSK61.08820882
63TTK1.08774315
64WNK11.04023881
65OXSR11.03903034
66STK101.00942985
67PDK21.00743997
68IRAK30.98499942
69ADRBK20.96838472
70EPHB20.95600820
71JAK30.93824241
72PHKG10.93427709
73PHKG20.93427709
74TAF10.91364780
75NTRK10.90462048
76MAP3K120.89238121
77MAPKAPK30.87839033
78EIF2AK20.87308486
79SGK30.85977152
80MAPK130.85956920
81STK38L0.83611323
82NUAK10.80573697
83AKT30.77268167
84MKNK10.77208706
85PINK10.76719286
86LATS10.75136317
87MELK0.75094145
88PRKCE0.74570230
89PRKG20.74439177
90PLK10.74373553
91WNK40.74153797
92FGFR10.69685036
93MAP3K110.67911853
94CAMK40.67151124
95INSRR0.66570015
96PTK2B0.65932430
97RPS6KL10.65784745
98RPS6KC10.65784745
99VRK10.65722818
100CSNK1G30.64472809
101FGFR30.63589039
102CSNK1G20.63380857
103FER0.61658583
104TYK20.61180881
105CAMKK20.60788033
106PRKD30.60134056
107RPS6KA60.59515928
108STK390.59097940
109SGK4940.57436164
110SGK2230.57436164
111ROCK10.57408508
112MAP3K70.56621440
113BLK0.56315273
114TBK10.56194685
115IKBKB0.55439713
116PRKAA20.55253280
117EPHB10.54289962
118BRSK20.54229199
119STK40.53546648
120RIPK10.53330273
121PKN20.53313076
122IKBKE0.53138530
123ILK0.53061034
124CSNK1A1L0.51319366
125MAP2K60.51011454
126JAK10.49536036
127STK160.49074469
128MARK30.48384487
129RPS6KA20.47690357
130TNK20.47492592
131IRAK10.47309455
132PRKD10.46160073
133SYK0.45466659
134MAPK120.45272462
135CDC42BPA0.45259289
136SRPK10.44612574
137MAP3K30.43006633
138ADRBK10.42899479
139CHUK0.42891907
140ITK0.42826191
141IGF1R0.41877730
142VRK20.41866337
143HIPK20.41365622
144PASK0.40680095
145ATM0.39502833
146PRKD20.38811670
147PAK40.37719511
148ROCK20.35248135
149MINK10.32543972
150PRKCG0.32128718
151EGFR0.29318427
152LIMK10.26803577
153BRSK10.26010499
154PRKG10.25940961
155CAMK2D0.24516540
156CDC70.23622934

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.93132177
2Proteasome_Homo sapiens_hsa030503.23276350
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.04151589
4Propanoate metabolism_Homo sapiens_hsa006402.83375285
5Dilated cardiomyopathy_Homo sapiens_hsa054142.76519802
6Cardiac muscle contraction_Homo sapiens_hsa042602.75379569
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.70034572
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.69863310
9Non-homologous end-joining_Homo sapiens_hsa034502.68687331
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.64500406
11Steroid biosynthesis_Homo sapiens_hsa001002.23446229
12Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.16707804
13Basal transcription factors_Homo sapiens_hsa030221.97759532
14Butanoate metabolism_Homo sapiens_hsa006501.93575557
15Vitamin B6 metabolism_Homo sapiens_hsa007501.91390307
16Selenocompound metabolism_Homo sapiens_hsa004501.89762890
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82016709
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.79478401
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71920402
20Sulfur metabolism_Homo sapiens_hsa009201.70171272
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69091226
22Fatty acid elongation_Homo sapiens_hsa000621.68018772
23Viral myocarditis_Homo sapiens_hsa054161.64760721
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63394781
25Leishmaniasis_Homo sapiens_hsa051401.62829744
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61814243
27Homologous recombination_Homo sapiens_hsa034401.61454762
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.60154132
29Platelet activation_Homo sapiens_hsa046111.54566621
30RNA degradation_Homo sapiens_hsa030181.53355072
31ECM-receptor interaction_Homo sapiens_hsa045121.50636583
32Focal adhesion_Homo sapiens_hsa045101.49211618
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47363198
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.45378440
35Fanconi anemia pathway_Homo sapiens_hsa034601.42311414
36Parkinsons disease_Homo sapiens_hsa050121.41218102
37Thyroid cancer_Homo sapiens_hsa052161.39914242
38Toxoplasmosis_Homo sapiens_hsa051451.39895572
39Measles_Homo sapiens_hsa051621.38306419
40Osteoclast differentiation_Homo sapiens_hsa043801.36790259
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33725208
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32837687
43Allograft rejection_Homo sapiens_hsa053301.32119817
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.31599098
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30179597
46Tryptophan metabolism_Homo sapiens_hsa003801.29086533
47Mismatch repair_Homo sapiens_hsa034301.28127031
48Pyruvate metabolism_Homo sapiens_hsa006201.24528758
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.23548039
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22694340
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.21167270
52Phototransduction_Homo sapiens_hsa047441.20943404
53Peroxisome_Homo sapiens_hsa041461.20502736
54Hematopoietic cell lineage_Homo sapiens_hsa046401.19660573
55Nitrogen metabolism_Homo sapiens_hsa009101.18800924
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18748897
57Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17732568
58Regulation of autophagy_Homo sapiens_hsa041401.17324130
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17129806
60Primary bile acid biosynthesis_Homo sapiens_hsa001201.16404382
61Glutathione metabolism_Homo sapiens_hsa004801.16378411
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14328219
63Fatty acid degradation_Homo sapiens_hsa000711.13677011
64Adherens junction_Homo sapiens_hsa045201.13194073
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12106356
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12054285
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11808188
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09770872
69One carbon pool by folate_Homo sapiens_hsa006701.09556559
70cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09359015
71Cysteine and methionine metabolism_Homo sapiens_hsa002701.08827498
72Primary immunodeficiency_Homo sapiens_hsa053401.08094935
73Caffeine metabolism_Homo sapiens_hsa002321.06369915
74RNA transport_Homo sapiens_hsa030131.06297913
75Acute myeloid leukemia_Homo sapiens_hsa052211.05255409
76SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04629351
77RNA polymerase_Homo sapiens_hsa030201.03579448
78HIF-1 signaling pathway_Homo sapiens_hsa040661.02184851
79Oxidative phosphorylation_Homo sapiens_hsa001900.97644346
80Fatty acid metabolism_Homo sapiens_hsa012120.96415652
81Malaria_Homo sapiens_hsa051440.96283670
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96035205
83Influenza A_Homo sapiens_hsa051640.94306574
84Hippo signaling pathway_Homo sapiens_hsa043900.93856309
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.93812372
86Pathways in cancer_Homo sapiens_hsa052000.93625129
87Basal cell carcinoma_Homo sapiens_hsa052170.92893953
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91841514
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.91790713
90B cell receptor signaling pathway_Homo sapiens_hsa046620.91549244
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91467750
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90349754
93Salmonella infection_Homo sapiens_hsa051320.89494626
94Herpes simplex infection_Homo sapiens_hsa051680.89470977
95Calcium signaling pathway_Homo sapiens_hsa040200.88601068
96Alzheimers disease_Homo sapiens_hsa050100.88559133
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88028494
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87120394
99Pertussis_Homo sapiens_hsa051330.86822272
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85442298
101Small cell lung cancer_Homo sapiens_hsa052220.85150752
102Tight junction_Homo sapiens_hsa045300.84533702
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84414747
104Vitamin digestion and absorption_Homo sapiens_hsa049770.83152990
105Ether lipid metabolism_Homo sapiens_hsa005650.81270925
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80911454
107Huntingtons disease_Homo sapiens_hsa050160.80678241
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.80674061
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.79703483
110beta-Alanine metabolism_Homo sapiens_hsa004100.79417519
111Oocyte meiosis_Homo sapiens_hsa041140.78922205
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78590106
113Proteoglycans in cancer_Homo sapiens_hsa052050.78341275
114Asthma_Homo sapiens_hsa053100.78041397
115Graft-versus-host disease_Homo sapiens_hsa053320.77294951
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77004188
117Retinol metabolism_Homo sapiens_hsa008300.76819338
118TNF signaling pathway_Homo sapiens_hsa046680.76269280
119Melanogenesis_Homo sapiens_hsa049160.76017440
120Amoebiasis_Homo sapiens_hsa051460.75824121
121Rap1 signaling pathway_Homo sapiens_hsa040150.75326836
122cAMP signaling pathway_Homo sapiens_hsa040240.74481316
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74234433
124Nucleotide excision repair_Homo sapiens_hsa034200.73630592
125Wnt signaling pathway_Homo sapiens_hsa043100.73359953
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.73183457
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73111974
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72662170
129p53 signaling pathway_Homo sapiens_hsa041150.72445147
130TGF-beta signaling pathway_Homo sapiens_hsa043500.72031504
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71591842
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71553147
133Purine metabolism_Homo sapiens_hsa002300.70121720
134Autoimmune thyroid disease_Homo sapiens_hsa053200.69796524
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68723825
136Protein digestion and absorption_Homo sapiens_hsa049740.67569072
137Circadian rhythm_Homo sapiens_hsa047100.67156578
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66470536
139Tuberculosis_Homo sapiens_hsa051520.64790293
140Renin secretion_Homo sapiens_hsa049240.64736657
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64695761
142alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64577669
143Metabolic pathways_Homo sapiens_hsa011000.63495247
144Chemical carcinogenesis_Homo sapiens_hsa052040.63037293
145Sphingolipid metabolism_Homo sapiens_hsa006000.62591213
146Cell cycle_Homo sapiens_hsa041100.62258176
147Fat digestion and absorption_Homo sapiens_hsa049750.61031503
148Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60795553
149Oxytocin signaling pathway_Homo sapiens_hsa049210.58745824
150Shigellosis_Homo sapiens_hsa051310.58189113
151N-Glycan biosynthesis_Homo sapiens_hsa005100.57936120
152Folate biosynthesis_Homo sapiens_hsa007900.57891183
153Insulin resistance_Homo sapiens_hsa049310.57745611
154Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56517851
155Chemokine signaling pathway_Homo sapiens_hsa040620.55833627
156African trypanosomiasis_Homo sapiens_hsa051430.55748608
157Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55589909
158Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55247020
159Mineral absorption_Homo sapiens_hsa049780.55145423
160Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53717192
161Starch and sucrose metabolism_Homo sapiens_hsa005000.52906911
162Endometrial cancer_Homo sapiens_hsa052130.52551342
163Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52015236
164HTLV-I infection_Homo sapiens_hsa051660.51358972
165Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50234912
166Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49536752
167Galactose metabolism_Homo sapiens_hsa000520.49183667
168Hedgehog signaling pathway_Homo sapiens_hsa043400.48862637
169Ovarian steroidogenesis_Homo sapiens_hsa049130.47740339
170Prolactin signaling pathway_Homo sapiens_hsa049170.47378409
171Prostate cancer_Homo sapiens_hsa052150.46933434
172Pancreatic cancer_Homo sapiens_hsa052120.46201083
173Insulin secretion_Homo sapiens_hsa049110.46196428
174Apoptosis_Homo sapiens_hsa042100.46137280
175Linoleic acid metabolism_Homo sapiens_hsa005910.44157876
176Complement and coagulation cascades_Homo sapiens_hsa046100.42734589
177Olfactory transduction_Homo sapiens_hsa047400.37651971
178Collecting duct acid secretion_Homo sapiens_hsa049660.35657028
179Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35263059
180Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34545183
181ABC transporters_Homo sapiens_hsa020100.33354554

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