PHACTR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the phosphatase and actin regulator protein family. The encoded protein is associated with the nuclear scaffold in proliferating cells, and binds to actin and the catalytic subunit of protein phosphatase-1, suggesting that it functions as a regulatory subunit of protein phosphatase-1. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.16131202
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.06989807
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.01117764
4locomotory exploration behavior (GO:0035641)5.00331601
5axon ensheathment in central nervous system (GO:0032291)4.87904933
6central nervous system myelination (GO:0022010)4.87904933
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.71481873
8synaptic vesicle maturation (GO:0016188)4.66477599
9vocalization behavior (GO:0071625)4.62914659
10synaptic vesicle exocytosis (GO:0016079)4.49389425
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.43202383
12presynaptic membrane assembly (GO:0097105)4.40407866
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.35907536
14neuronal action potential propagation (GO:0019227)4.35593549
15transmission of nerve impulse (GO:0019226)4.33787169
16protein localization to synapse (GO:0035418)4.26022969
17regulation of synaptic vesicle exocytosis (GO:2000300)4.16325611
18regulation of glutamate receptor signaling pathway (GO:1900449)4.13282479
19glutamate secretion (GO:0014047)4.12108068
20presynaptic membrane organization (GO:0097090)4.08799452
21dendritic spine morphogenesis (GO:0060997)4.06912308
22pyrimidine nucleobase catabolic process (GO:0006208)3.99896151
23L-amino acid import (GO:0043092)3.92193376
24synaptic transmission, glutamatergic (GO:0035249)3.91342667
25glutamate receptor signaling pathway (GO:0007215)3.90234923
26exploration behavior (GO:0035640)3.88161005
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.82203524
28regulation of neuronal synaptic plasticity (GO:0048168)3.79823654
29gamma-aminobutyric acid transport (GO:0015812)3.77744208
30neuron-neuron synaptic transmission (GO:0007270)3.71701862
31neuron recognition (GO:0008038)3.70315900
32layer formation in cerebral cortex (GO:0021819)3.69480317
33neurotransmitter-gated ion channel clustering (GO:0072578)3.66942196
34positive regulation of membrane potential (GO:0045838)3.66819485
35regulation of dendritic spine morphogenesis (GO:0061001)3.63255755
36neuronal ion channel clustering (GO:0045161)3.59644934
37neurotransmitter secretion (GO:0007269)3.58240798
38regulation of synaptic vesicle transport (GO:1902803)3.55573748
39cerebellar granule cell differentiation (GO:0021707)3.50007983
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.48846603
41regulation of synapse structural plasticity (GO:0051823)3.48447152
42negative regulation of neurotransmitter transport (GO:0051589)3.46617040
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.45159952
44myelination (GO:0042552)3.44294331
45membrane depolarization during action potential (GO:0086010)3.43772495
46positive regulation of dendritic spine morphogenesis (GO:0061003)3.43617559
47long-term memory (GO:0007616)3.42740895
48central nervous system projection neuron axonogenesis (GO:0021952)3.42244851
49startle response (GO:0001964)3.41153390
50dendrite morphogenesis (GO:0048813)3.40034023
51axon ensheathment (GO:0008366)3.38278651
52ensheathment of neurons (GO:0007272)3.38278651
53negative regulation of neurotransmitter secretion (GO:0046929)3.38176271
54positive regulation of synapse maturation (GO:0090129)3.36898438
55nucleobase catabolic process (GO:0046113)3.36751283
56postsynaptic membrane organization (GO:0001941)3.35998578
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.35867117
58axonal fasciculation (GO:0007413)3.34946373
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.33268690
60regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.33007708
61regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.28023753
62regulation of postsynaptic membrane potential (GO:0060078)3.27990911
63auditory behavior (GO:0031223)3.26827663
64adult walking behavior (GO:0007628)3.25369058
65positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.24588898
66establishment of mitochondrion localization (GO:0051654)3.22475568
67regulation of dendritic spine development (GO:0060998)3.21302078
68negative regulation of dendrite development (GO:2000171)3.21102362
69synaptic vesicle docking involved in exocytosis (GO:0016081)3.19640613
70amino acid import (GO:0043090)3.18372082
71negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.18291283
72negative regulation of synaptic transmission, GABAergic (GO:0032229)3.16799302
73regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.16265627
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.14826930
75regulation of synaptic plasticity (GO:0048167)3.14278655
76neurotransmitter transport (GO:0006836)3.10455286
77long-chain fatty acid biosynthetic process (GO:0042759)3.10001941
78long-term synaptic potentiation (GO:0060291)3.06878128
79retinal cone cell development (GO:0046549)3.06795570
80regulation of neurotransmitter secretion (GO:0046928)3.05409784
81regulation of vesicle fusion (GO:0031338)3.05406008
82positive regulation of dendritic spine development (GO:0060999)3.03556738
83membrane hyperpolarization (GO:0060081)3.03436625
84cell migration in hindbrain (GO:0021535)3.02171008
85glycosphingolipid biosynthetic process (GO:0006688)3.01575755
86serotonin metabolic process (GO:0042428)3.00123147
87response to auditory stimulus (GO:0010996)2.99851795
88neuronal action potential (GO:0019228)2.97619444
89neuromuscular process controlling balance (GO:0050885)2.97500978
90central nervous system neuron axonogenesis (GO:0021955)2.94789127
91G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.94416973
92regulation of voltage-gated calcium channel activity (GO:1901385)2.93865804
93positive regulation of synaptic transmission, GABAergic (GO:0032230)2.93595314
94negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.92942704
95prepulse inhibition (GO:0060134)2.92070097
96synapse assembly (GO:0007416)2.90575816
97learning (GO:0007612)2.90061659
98synaptic transmission (GO:0007268)2.89838303
99cerebral cortex radially oriented cell migration (GO:0021799)2.89476635
100dendritic spine organization (GO:0097061)2.89283041
101regulation of neurotransmitter levels (GO:0001505)2.89094486
102neuromuscular synaptic transmission (GO:0007274)2.88337937
103cellular potassium ion homeostasis (GO:0030007)2.87603698
104membrane depolarization (GO:0051899)2.85908094
105regulation of synapse maturation (GO:0090128)2.85569302
106regulation of neurotransmitter transport (GO:0051588)2.85006975
107behavioral response to nicotine (GO:0035095)2.84763837
108negative regulation of axonogenesis (GO:0050771)2.84420683
109synaptic vesicle endocytosis (GO:0048488)2.83891444
110neurofilament cytoskeleton organization (GO:0060052)2.83711424
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.81388343
112primary amino compound metabolic process (GO:1901160)2.81018146
113synapse organization (GO:0050808)2.80571371
114regulation of glutamate secretion (GO:0014048)2.80322573
115cerebellar Purkinje cell differentiation (GO:0021702)2.78355727
116mating behavior (GO:0007617)2.77437404
117neurotransmitter catabolic process (GO:0042135)2.77036435
118behavioral response to cocaine (GO:0048148)2.76235291
119establishment of synaptic vesicle localization (GO:0097480)2.75883849
120synaptic vesicle transport (GO:0048489)2.75883849
121regulation of dendrite morphogenesis (GO:0048814)2.75806381
122proline transport (GO:0015824)2.75688889
123sodium ion export (GO:0071436)2.75217104
124mechanosensory behavior (GO:0007638)2.75060652
125dendrite development (GO:0016358)2.74614257
126positive regulation of synapse assembly (GO:0051965)2.74564218
127neurotransmitter uptake (GO:0001504)2.74199544
128calcium ion-dependent exocytosis (GO:0017156)2.73485352

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.07698173
2GBX2_23144817_ChIP-Seq_PC3_Human3.71938600
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07222419
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04535078
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99785904
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64949972
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64949972
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.61132021
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53582572
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50943388
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47479988
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47135568
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46285755
14REST_21632747_ChIP-Seq_MESCs_Mouse2.44764321
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41875589
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.32013429
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.31162076
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.29706515
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27388643
20* DROSHA_22980978_ChIP-Seq_HELA_Human2.25761050
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.17516426
22AR_21572438_ChIP-Seq_LNCaP_Human2.03916910
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96885099
24TAF15_26573619_Chip-Seq_HEK293_Human1.95737550
25* REST_18959480_ChIP-ChIP_MESCs_Mouse1.94651158
26IGF1R_20145208_ChIP-Seq_DFB_Human1.85336196
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82357235
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75770565
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75714715
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70087119
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69119793
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68642094
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62717942
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60143498
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56918115
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.53265888
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52256924
38SMAD4_21799915_ChIP-Seq_A2780_Human1.50331764
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50009136
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48814365
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48562641
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48104534
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.46424214
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44831674
45P300_19829295_ChIP-Seq_ESCs_Human1.44064987
46* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38229252
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38145798
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.36683573
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35444696
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33127247
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30168762
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.29273864
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28073815
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27932355
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.25363581
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25352374
57ZNF274_21170338_ChIP-Seq_K562_Hela1.25178973
58VDR_22108803_ChIP-Seq_LS180_Human1.24869741
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24445738
60RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23212694
61* STAT3_23295773_ChIP-Seq_U87_Human1.20989928
62* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20856491
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19260654
64RNF2_27304074_Chip-Seq_NSC_Mouse1.18781646
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17304679
66* ER_23166858_ChIP-Seq_MCF-7_Human1.16513927
67FUS_26573619_Chip-Seq_HEK293_Human1.15934961
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14733890
69EWS_26573619_Chip-Seq_HEK293_Human1.14306608
70* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12992004
71* AR_25329375_ChIP-Seq_VCAP_Human1.11140989
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11093960
73CBP_20019798_ChIP-Seq_JUKART_Human1.11093960
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.10938817
75BCAT_22108803_ChIP-Seq_LS180_Human1.10404960
76* TCF4_23295773_ChIP-Seq_U87_Human1.09889487
77* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09798776
78MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08857828
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08701161
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08172955
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06766922
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05839003
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.05674681
84* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05651920
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04624056
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04591559
87* AR_19668381_ChIP-Seq_PC3_Human1.04388996
88* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03688073
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02825813
90KDM2B_26808549_Chip-Seq_REH_Human1.02735746
91RUNX2_22187159_ChIP-Seq_PCA_Human1.01340790
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.01262155
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00290597
94* PRDM14_20953172_ChIP-Seq_ESCs_Human0.99256600
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98431084
96KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98398883
97TCF4_22108803_ChIP-Seq_LS180_Human0.97342962
98* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97052772
99* NANOG_18555785_Chip-Seq_ESCs_Mouse0.96284709
100SMAD_19615063_ChIP-ChIP_OVARY_Human0.95039442
101* SMAD4_21741376_ChIP-Seq_EPCs_Human0.94811480
102AHR_22903824_ChIP-Seq_MCF-7_Human0.94543690
103YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92560887
104SMAD3_21741376_ChIP-Seq_ESCs_Human0.91655457
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90227975
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90227975
107DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89556415
108JUN_21703547_ChIP-Seq_K562_Human0.87291030
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.87061357
110STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86896432
111TP53_18474530_ChIP-ChIP_U2OS_Human0.86241371
112* CMYC_18555785_Chip-Seq_ESCs_Mouse0.85771037
113TP53_16413492_ChIP-PET_HCT116_Human0.85218852
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85153437
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84512042
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84495402
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83961185

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.67831726
2MP0003880_abnormal_central_pattern4.96438851
3MP0004270_analgesia4.07111154
4MP0003635_abnormal_synaptic_transmissio3.75994936
5MP0009745_abnormal_behavioral_response3.28781880
6MP0002064_seizures3.14440977
7MP0002063_abnormal_learning/memory/cond3.00493786
8MP0005423_abnormal_somatic_nervous2.99600915
9MP0002822_catalepsy2.93932699
10MP0009046_muscle_twitch2.90910951
11MP0001486_abnormal_startle_reflex2.84561556
12MP0002272_abnormal_nervous_system2.79741941
13MP0002572_abnormal_emotion/affect_behav2.63837976
14MP0002734_abnormal_mechanical_nocicepti2.60085578
15MP0001968_abnormal_touch/_nociception2.55139824
16MP0000920_abnormal_myelination2.29795926
17MP0001440_abnormal_grooming_behavior2.25744693
18MP0000778_abnormal_nervous_system2.23336415
19MP0001529_abnormal_vocalization2.23214728
20MP0003329_amyloid_beta_deposits2.09237635
21MP0001501_abnormal_sleep_pattern1.99071143
22MP0002736_abnormal_nociception_after1.99013415
23MP0004885_abnormal_endolymph1.96477414
24MP0002735_abnormal_chemical_nociception1.92779193
25MP0001905_abnormal_dopamine_level1.90848083
26MP0002067_abnormal_sensory_capabilities1.90422823
27MP0002733_abnormal_thermal_nociception1.90418356
28MP0001970_abnormal_pain_threshold1.85304239
29MP0008569_lethality_at_weaning1.80739008
30MP0005386_behavior/neurological_phenoty1.78423088
31MP0004924_abnormal_behavior1.78423088
32MP0003690_abnormal_glial_cell1.75432500
33MP0000569_abnormal_digit_pigmentation1.70212714
34MP0008877_abnormal_DNA_methylation1.67333976
35MP0004742_abnormal_vestibular_system1.65815869
36MP0002557_abnormal_social/conspecific_i1.65442154
37MP0000955_abnormal_spinal_cord1.64307763
38MP0002184_abnormal_innervation1.64011195
39MP0005646_abnormal_pituitary_gland1.59144830
40MP0004142_abnormal_muscle_tone1.56668187
41MP0002882_abnormal_neuron_morphology1.55844938
42MP0009780_abnormal_chondrocyte_physiolo1.51251642
43MP0004811_abnormal_neuron_physiology1.50044469
44MP0006276_abnormal_autonomic_nervous1.49824823
45MP0002066_abnormal_motor_capabilities/c1.49314264
46MP0001984_abnormal_olfaction1.43435175
47MP0005409_darkened_coat_color1.42957507
48MP0002102_abnormal_ear_morphology1.41785137
49MP0003634_abnormal_glial_cell1.41486464
50MP0001485_abnormal_pinna_reflex1.33454734
51MP0002229_neurodegeneration1.31570515
52MP0004858_abnormal_nervous_system1.30473246
53MP0005645_abnormal_hypothalamus_physiol1.30336212
54MP0003633_abnormal_nervous_system1.26803833
55MP0001502_abnormal_circadian_rhythm1.22705525
56MP0003631_nervous_system_phenotype1.22333712
57MP0005551_abnormal_eye_electrophysiolog1.18988671
58MP0003632_abnormal_nervous_system1.17555716
59MP0002152_abnormal_brain_morphology1.17316379
60MP0005171_absent_coat_pigmentation1.13388556
61MP0001188_hyperpigmentation1.09811511
62MP0003121_genomic_imprinting1.09410684
63MP0001963_abnormal_hearing_physiology1.06394738
64MP0002909_abnormal_adrenal_gland1.04906078
65MP0003879_abnormal_hair_cell1.02929683
66MP0003787_abnormal_imprinting1.01255459
67MP0002752_abnormal_somatic_nervous1.00354810
68MP0001986_abnormal_taste_sensitivity0.96731038
69MP0003136_yellow_coat_color0.95103483
70MP0004145_abnormal_muscle_electrophysio0.94863595
71MP0002653_abnormal_ependyma_morphology0.90708643
72MP0000604_amyloidosis0.89575327
73MP0000631_abnormal_neuroendocrine_gland0.88698886
74MP0001177_atelectasis0.85587042
75MP0002069_abnormal_eating/drinking_beha0.85287450
76MP0005670_abnormal_white_adipose0.81843491
77MP0004133_heterotaxia0.81427129
78MP0005410_abnormal_fertilization0.81316480
79MP0002090_abnormal_vision0.81098769
80MP0008874_decreased_physiological_sensi0.79397614
81MP0002234_abnormal_pharynx_morphology0.78884411
82MP0000751_myopathy0.78536973
83MP0001299_abnormal_eye_distance/0.77939345
84MP0004085_abnormal_heartbeat0.77386216
85MP0006292_abnormal_olfactory_placode0.75620431
86MP0008872_abnormal_physiological_respon0.74529220
87MP0005187_abnormal_penis_morphology0.72701305
88MP0004147_increased_porphyrin_level0.72421942
89MP0002751_abnormal_autonomic_nervous0.72141402
90MP0003137_abnormal_impulse_conducting0.71280058
91MP0003122_maternal_imprinting0.71088403
92MP0000026_abnormal_inner_ear0.71021338
93MP0005394_taste/olfaction_phenotype0.67398321
94MP0005499_abnormal_olfactory_system0.67398321
95MP0006072_abnormal_retinal_apoptosis0.67321650
96MP0005623_abnormal_meninges_morphology0.66815069
97MP0002876_abnormal_thyroid_physiology0.66764021
98MP0003119_abnormal_digestive_system0.65908317
99MP0003861_abnormal_nervous_system0.65737479
100MP0003938_abnormal_ear_development0.65701196
101MP0004215_abnormal_myocardial_fiber0.64613173
102MP0005535_abnormal_body_temperature0.63967123
103MP0001664_abnormal_digestion0.63478233
104MP0000462_abnormal_digestive_system0.63465947
105MP0010386_abnormal_urinary_bladder0.63429125
106MP0003075_altered_response_to0.63309001
107MP0002638_abnormal_pupillary_reflex0.62436519
108MP0005167_abnormal_blood-brain_barrier0.59950393
109MP0004043_abnormal_pH_regulation0.59743414
110MP0004130_abnormal_muscle_cell0.59136712
111MP0000427_abnormal_hair_cycle0.59135698
112MP0001943_abnormal_respiration0.58961147
113MP0005253_abnormal_eye_physiology0.56614556
114MP0003698_abnormal_male_reproductive0.55947493
115MP0008789_abnormal_olfactory_epithelium0.53684464
116MP0005195_abnormal_posterior_eye0.52127739
117MP0010769_abnormal_survival0.51725078
118MP0000747_muscle_weakness0.50756269
119MP0002082_postnatal_lethality0.49842514
120MP0010770_preweaning_lethality0.49842514
121MP0010768_mortality/aging0.48266449

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.64200833
2Focal motor seizures (HP:0011153)6.36664729
3Focal seizures (HP:0007359)4.82052014
4Neurofibrillary tangles (HP:0002185)4.51102621
5Atonic seizures (HP:0010819)4.38412700
6Epileptic encephalopathy (HP:0200134)4.18024516
7Visual hallucinations (HP:0002367)4.03248208
8Supranuclear gaze palsy (HP:0000605)3.97107752
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.89141676
10Degeneration of the lateral corticospinal tracts (HP:0002314)3.89141676
11Abnormality of the corticospinal tract (HP:0002492)3.76088087
12Cerebral inclusion bodies (HP:0100314)3.70047143
13Progressive cerebellar ataxia (HP:0002073)3.59831102
14Dysmetria (HP:0001310)3.55351425
15Action tremor (HP:0002345)3.54204210
16Spastic gait (HP:0002064)3.53861961
17Absence seizures (HP:0002121)3.47028496
18Broad-based gait (HP:0002136)3.35796447
19Ankle clonus (HP:0011448)3.35607558
20Dialeptic seizures (HP:0011146)3.34623298
21Febrile seizures (HP:0002373)3.27042985
22Generalized tonic-clonic seizures (HP:0002069)3.26767202
23Intention tremor (HP:0002080)3.23088622
24Hyperventilation (HP:0002883)3.20312018
25Sensory axonal neuropathy (HP:0003390)3.19393667
26Dysdiadochokinesis (HP:0002075)3.02013102
27Scanning speech (HP:0002168)2.99431196
28Gaze-evoked nystagmus (HP:0000640)2.97681129
29Peripheral hypomyelination (HP:0007182)2.92507912
30Megalencephaly (HP:0001355)2.85523492
31Insidious onset (HP:0003587)2.84971802
32Termporal pattern (HP:0011008)2.84971802
33Akinesia (HP:0002304)2.81574046
34Impaired vibration sensation in the lower limbs (HP:0002166)2.80785198
35Urinary bladder sphincter dysfunction (HP:0002839)2.80095604
36Abnormal eating behavior (HP:0100738)2.72938351
37Anxiety (HP:0000739)2.71035900
38Status epilepticus (HP:0002133)2.68540808
39Abnormality of the labia minora (HP:0012880)2.65182665
40Progressive inability to walk (HP:0002505)2.64046133
41Hemiparesis (HP:0001269)2.63971475
42Amyotrophic lateral sclerosis (HP:0007354)2.60221812
43Poor eye contact (HP:0000817)2.52955366
44Truncal ataxia (HP:0002078)2.49841760
45Amblyopia (HP:0000646)2.49730234
46Depression (HP:0000716)2.47605359
47Mutism (HP:0002300)2.47291419
48Protruding tongue (HP:0010808)2.45783342
49Pheochromocytoma (HP:0002666)2.44894921
50Postural instability (HP:0002172)2.44041262
51Urinary urgency (HP:0000012)2.43207856
52Lower limb muscle weakness (HP:0007340)2.43083044
53Drooling (HP:0002307)2.37968181
54Excessive salivation (HP:0003781)2.37968181
55Limb dystonia (HP:0002451)2.37654870
56Aplasia involving bones of the extremities (HP:0009825)2.34326280
57Aplasia involving bones of the upper limbs (HP:0009823)2.34326280
58Aplasia of the phalanges of the hand (HP:0009802)2.34326280
59Retinal dysplasia (HP:0007973)2.33905977
60Diplopia (HP:0000651)2.33215135
61Abnormality of binocular vision (HP:0011514)2.33215135
62Generalized myoclonic seizures (HP:0002123)2.32930090
63Thickened helices (HP:0000391)2.28755672
64Absent speech (HP:0001344)2.26915949
65Fetal akinesia sequence (HP:0001989)2.26581054
66Impaired social interactions (HP:0000735)2.26131799
67Abnormal social behavior (HP:0012433)2.26131799
68True hermaphroditism (HP:0010459)2.24596389
69Polyphagia (HP:0002591)2.20804172
70Medial flaring of the eyebrow (HP:0010747)2.17519818
71Pancreatic cysts (HP:0001737)2.16095293
72Neuroendocrine neoplasm (HP:0100634)2.15718307
73Pancreatic fibrosis (HP:0100732)2.15300416
74Onion bulb formation (HP:0003383)2.15143518
75Torticollis (HP:0000473)2.15105998
76Abnormality of midbrain morphology (HP:0002418)2.06589427
77Molar tooth sign on MRI (HP:0002419)2.06589427
78Stereotypic behavior (HP:0000733)2.05525393
79Absent/shortened dynein arms (HP:0200106)2.04045540
80Dynein arm defect of respiratory motile cilia (HP:0012255)2.04045540
81Epileptiform EEG discharges (HP:0011182)2.03496948
82Alacrima (HP:0000522)2.03111540
83Lissencephaly (HP:0001339)2.02417100
84Impaired smooth pursuit (HP:0007772)2.02165983
85Congenital stationary night blindness (HP:0007642)1.99737977
86Congenital primary aphakia (HP:0007707)1.98971325
87Split foot (HP:0001839)1.98352612
88EEG with generalized epileptiform discharges (HP:0011198)1.98221128
89Clonus (HP:0002169)1.97523156
90Focal dystonia (HP:0004373)1.96226421
91Hypoplasia of the corpus callosum (HP:0002079)1.96165900
92Nephronophthisis (HP:0000090)1.94565314
93Genital tract atresia (HP:0001827)1.93794634
94Type II lissencephaly (HP:0007260)1.93226407
95Genetic anticipation (HP:0003743)1.91568457
96Blue irides (HP:0000635)1.91127981
97Clumsiness (HP:0002312)1.90394326
98Hypsarrhythmia (HP:0002521)1.90221112
99Spastic tetraparesis (HP:0001285)1.88421719
100Inability to walk (HP:0002540)1.86618169
101Gait imbalance (HP:0002141)1.86067483
102Esotropia (HP:0000565)1.86060645
103Increased circulating renin level (HP:0000848)1.85918410
104Pachygyria (HP:0001302)1.85794796
105Cerebral hypomyelination (HP:0006808)1.85594104
106Bradykinesia (HP:0002067)1.84112969
107Neuronal loss in central nervous system (HP:0002529)1.83872597
108Hemiplegia (HP:0002301)1.83397604
109Parakeratosis (HP:0001036)1.82981056
110Bowel incontinence (HP:0002607)1.82867604
111Vaginal atresia (HP:0000148)1.81718473
112Optic nerve hypoplasia (HP:0000609)1.81603015
113Impaired vibratory sensation (HP:0002495)1.81341048
114Papilledema (HP:0001085)1.81184878
115Morphological abnormality of the pyramidal tract (HP:0002062)1.81052799
116Nephrogenic diabetes insipidus (HP:0009806)1.80778313
117Specific learning disability (HP:0001328)1.80497255
118Slow saccadic eye movements (HP:0000514)1.78204173
119Failure to thrive in infancy (HP:0001531)1.77823625
120Spastic tetraplegia (HP:0002510)1.77478009
121Abnormality of saccadic eye movements (HP:0000570)1.77158656
122Sleep apnea (HP:0010535)1.77141691
123Abnormality of salivation (HP:0100755)1.75732784
124Delusions (HP:0000746)1.75415248
125Psychosis (HP:0000709)1.74219774
126Incomplete penetrance (HP:0003829)1.73802541
127Craniofacial dystonia (HP:0012179)1.72825073
128Exotropia (HP:0000577)1.72761459
129Congenital sensorineural hearing impairment (HP:0008527)1.72374054
130Paraplegia (HP:0010550)1.70864376
131Oligodactyly (hands) (HP:0001180)1.70497433
132Intellectual disability, severe (HP:0010864)1.70287209
133Abnormality of ocular smooth pursuit (HP:0000617)1.69789759
134Pendular nystagmus (HP:0012043)1.69354528
135CNS hypomyelination (HP:0003429)1.68988519

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.22255920
2NTRK33.33808507
3FRK3.22445333
4MARK13.12875787
5STK392.92520377
6TNIK2.86749606
7MAP3K92.86207518
8OXSR12.58034703
9CASK2.40040070
10PAK62.18817314
11MAP3K42.16661146
12CDK192.12005775
13MINK12.07306304
14NTRK12.05133348
15NTRK22.02696338
16MAP4K21.93899604
17PRPF4B1.80224414
18MAP2K71.79272981
19PNCK1.70910729
20DAPK21.64803422
21KSR21.63800441
22UHMK11.62854043
23CDK51.55782163
24TYRO31.55768358
25MAPK131.50499104
26PRKD31.44938876
27BCR1.35829328
28FES1.31853313
29PKN11.28749662
30NEK61.25755915
31ARAF1.23527685
32WNK41.21186311
33KSR11.19987257
34GRK51.19320887
35CAMK2B1.16116407
36MAP3K121.14840870
37PHKG21.13937145
38PHKG11.13937145
39SGK4941.13517611
40SGK2231.13517611
41RIPK41.13428856
42MAP2K41.12765544
43WNK11.12553380
44FGR1.11830075
45CSNK1G21.10121293
46ICK1.05652218
47CAMK2A1.05367691
48CDK141.05237777
49PLK21.05037506
50CDK151.03525222
51CDK181.02550678
52TRIM281.02542693
53CAMKK11.01451705
54PRKCG0.98039094
55FGFR20.96852505
56PAK30.95316975
57MAP3K130.95044563
58MARK20.92695421
59CDK11A0.91715742
60ADRBK20.90898193
61CSNK1G30.90212327
62LIMK10.88384997
63MAP3K20.87340056
64ROCK20.86620957
65STK110.86106682
66SIK20.80629501
67INSRR0.80489149
68CCNB10.80191264
69CSNK1A1L0.77518578
70CAMK2D0.77355734
71DYRK1A0.73791755
72CAMK40.72526527
73MAPKAPK50.72515184
74GRK10.72088602
75BMPR20.68852604
76CAMK2G0.65054803
77PDPK10.64553218
78PRKCH0.64007360
79BMPR1B0.63824114
80PRKCE0.63260388
81PTK2B0.62495647
82NME10.62385970
83FYN0.61994356
84TAOK30.61609401
85RAF10.61458143
86CAMK10.61324506
87DAPK10.60564517
88MAP2K60.59658593
89SGK10.59560357
90CSNK1G10.57908180
91ERBB30.57222753
92DYRK20.56820118
93CAMKK20.53176243
94CSNK1D0.52081987
95ADRBK10.51983504
96MUSK0.50468023
97PDK10.49765630
98PRKCQ0.49270494
99PINK10.47871194
100PRKACA0.46371118
101WNK30.46285510
102TAOK20.45904636
103RET0.45580252
104SGK20.44666705
105IRAK20.44228276
106GRK70.43563769
107TAOK10.43005945
108CSNK1A10.41914604
109TNK20.41573400
110EPHB10.41197493
111MAPK120.41135498
112PRKCZ0.40991357
113RPS6KA30.40643410
114STK380.40222825
115CAMK1G0.40154490
116MAPK100.40118798
117DMPK0.39593554
118PRKG10.39414707
119SGK30.36636815
120PRKCA0.35783565
121PRKACB0.33358032
122CAMK1D0.33314877
123LMTK20.32753770
124GSK3B0.31974963
125MAPK80.31787939

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.51382620
2Synaptic vesicle cycle_Homo sapiens_hsa047212.82136763
3Glutamatergic synapse_Homo sapiens_hsa047242.76169852
4GABAergic synapse_Homo sapiens_hsa047272.74576281
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64894544
6Morphine addiction_Homo sapiens_hsa050322.51838810
7Circadian entrainment_Homo sapiens_hsa047132.50806497
8Olfactory transduction_Homo sapiens_hsa047402.40015191
9Long-term potentiation_Homo sapiens_hsa047202.31628108
10Amphetamine addiction_Homo sapiens_hsa050312.17687050
11Salivary secretion_Homo sapiens_hsa049702.10534895
12Dopaminergic synapse_Homo sapiens_hsa047282.05493808
13Serotonergic synapse_Homo sapiens_hsa047261.95225926
14Cholinergic synapse_Homo sapiens_hsa047251.92771432
15Long-term depression_Homo sapiens_hsa047301.86670910
16Gastric acid secretion_Homo sapiens_hsa049711.75975803
17Cocaine addiction_Homo sapiens_hsa050301.74478001
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.73751108
19Axon guidance_Homo sapiens_hsa043601.72233463
20Insulin secretion_Homo sapiens_hsa049111.71220897
21Taste transduction_Homo sapiens_hsa047421.65648272
22Renin secretion_Homo sapiens_hsa049241.56024166
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54871916
24Collecting duct acid secretion_Homo sapiens_hsa049661.51719890
25Oxytocin signaling pathway_Homo sapiens_hsa049211.50156193
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49136092
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47024451
28Calcium signaling pathway_Homo sapiens_hsa040201.44396336
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36783270
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35520750
31Gap junction_Homo sapiens_hsa045401.32673630
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27899626
33GnRH signaling pathway_Homo sapiens_hsa049121.27602549
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24005919
35Cardiac muscle contraction_Homo sapiens_hsa042601.21455589
36Nitrogen metabolism_Homo sapiens_hsa009101.17986271
37cAMP signaling pathway_Homo sapiens_hsa040241.16941040
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16069886
39Oxidative phosphorylation_Homo sapiens_hsa001901.06157367
40ErbB signaling pathway_Homo sapiens_hsa040121.05138484
41Ether lipid metabolism_Homo sapiens_hsa005651.04910965
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.03552809
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03515007
44Vibrio cholerae infection_Homo sapiens_hsa051101.02534659
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01857956
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.01710473
47Alzheimers disease_Homo sapiens_hsa050100.97856335
48Phototransduction_Homo sapiens_hsa047440.97486618
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96811693
50Steroid biosynthesis_Homo sapiens_hsa001000.93298097
51Melanogenesis_Homo sapiens_hsa049160.92818471
52Dorso-ventral axis formation_Homo sapiens_hsa043200.92774378
53Histidine metabolism_Homo sapiens_hsa003400.91035456
54Pancreatic secretion_Homo sapiens_hsa049720.90949171
55Estrogen signaling pathway_Homo sapiens_hsa049150.90579982
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87387246
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86707915
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84116053
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80889740
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80619314
61Glioma_Homo sapiens_hsa052140.79183319
62Type II diabetes mellitus_Homo sapiens_hsa049300.78365452
63Choline metabolism in cancer_Homo sapiens_hsa052310.78356699
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78201288
65Parkinsons disease_Homo sapiens_hsa050120.77605368
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.73934025
67Renal cell carcinoma_Homo sapiens_hsa052110.73719700
68Ras signaling pathway_Homo sapiens_hsa040140.73196196
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70484562
70beta-Alanine metabolism_Homo sapiens_hsa004100.68131284
71MAPK signaling pathway_Homo sapiens_hsa040100.67318356
72Regulation of autophagy_Homo sapiens_hsa041400.67224491
73Linoleic acid metabolism_Homo sapiens_hsa005910.66375824
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64982280
75Thyroid hormone synthesis_Homo sapiens_hsa049180.64368496
76Oocyte meiosis_Homo sapiens_hsa041140.63814377
77Endocytosis_Homo sapiens_hsa041440.63693619
78Butanoate metabolism_Homo sapiens_hsa006500.63119035
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62113130
80ABC transporters_Homo sapiens_hsa020100.60671749
81Dilated cardiomyopathy_Homo sapiens_hsa054140.60298012
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60283354
83Alcoholism_Homo sapiens_hsa050340.60218369
84Fatty acid elongation_Homo sapiens_hsa000620.59233659
85Ovarian steroidogenesis_Homo sapiens_hsa049130.57930538
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56965526
87Sphingolipid metabolism_Homo sapiens_hsa006000.51404954
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50358246
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48114507
90Rap1 signaling pathway_Homo sapiens_hsa040150.47994058
91Tight junction_Homo sapiens_hsa045300.47084735
92Wnt signaling pathway_Homo sapiens_hsa043100.45237072
93Huntingtons disease_Homo sapiens_hsa050160.43733312
94VEGF signaling pathway_Homo sapiens_hsa043700.43316106
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43074262
96Prion diseases_Homo sapiens_hsa050200.42376561
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40567088
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.40511800
99Fatty acid biosynthesis_Homo sapiens_hsa000610.37987934
100Inositol phosphate metabolism_Homo sapiens_hsa005620.37825688
101Rheumatoid arthritis_Homo sapiens_hsa053230.35987147
102Bile secretion_Homo sapiens_hsa049760.35677454
103Tryptophan metabolism_Homo sapiens_hsa003800.35561111
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35324853
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35277387
106Arginine and proline metabolism_Homo sapiens_hsa003300.35186930
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33620456
108Chemokine signaling pathway_Homo sapiens_hsa040620.32555364
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32439513
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32241832
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31713343
112African trypanosomiasis_Homo sapiens_hsa051430.31588704
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31191246
114Glycerolipid metabolism_Homo sapiens_hsa005610.30914545
115Circadian rhythm_Homo sapiens_hsa047100.30231328
116Glucagon signaling pathway_Homo sapiens_hsa049220.28116873
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.23838552
118Hippo signaling pathway_Homo sapiens_hsa043900.23816096

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