PHACTR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.80589886
2proline metabolic process (GO:0006560)5.53458892
3embryonic process involved in female pregnancy (GO:0060136)5.06870446
4negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.80503899
5negative regulation of translation, ncRNA-mediated (GO:0040033)4.80503899
6regulation of translation, ncRNA-mediated (GO:0045974)4.80503899
7transcription from mitochondrial promoter (GO:0006390)4.71249279
8replication fork processing (GO:0031297)4.37347314
9behavioral response to nicotine (GO:0035095)4.35554616
10regulation of integrin activation (GO:0033623)4.23466523
11indolalkylamine metabolic process (GO:0006586)4.12343801
12indole-containing compound catabolic process (GO:0042436)4.08600741
13indolalkylamine catabolic process (GO:0046218)4.08600741
14tryptophan catabolic process (GO:0006569)4.08600741
15cilium or flagellum-dependent cell motility (GO:0001539)4.07819750
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.04774445
17oxidative demethylation (GO:0070989)4.02355376
18establishment of apical/basal cell polarity (GO:0035089)3.99295696
19tryptophan metabolic process (GO:0006568)3.97455681
20negative regulation of fatty acid biosynthetic process (GO:0045717)3.86899682
21regulation of nuclear cell cycle DNA replication (GO:0033262)3.84561532
22sulfur amino acid catabolic process (GO:0000098)3.74953461
23axoneme assembly (GO:0035082)3.64558981
24maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.63997097
25embryonic placenta development (GO:0001892)3.62513746
26epithelial cilium movement (GO:0003351)3.56872116
27rRNA catabolic process (GO:0016075)3.54110108
28L-fucose metabolic process (GO:0042354)3.51131765
29L-fucose catabolic process (GO:0042355)3.51131765
30fucose catabolic process (GO:0019317)3.51131765
31regulation of telomere maintenance (GO:0032204)3.46157213
32microtubule depolymerization (GO:0007019)3.43978894
33positive regulation of protein homooligomerization (GO:0032464)3.40539273
34positive regulation by host of viral transcription (GO:0043923)3.40186476
35mitochondrial DNA metabolic process (GO:0032042)3.38440141
36glutamine family amino acid biosynthetic process (GO:0009084)3.38425847
37negative regulation of cell cycle arrest (GO:0071157)3.36995294
38cilium movement (GO:0003341)3.36677189
39protein polyglutamylation (GO:0018095)3.27535979
40negative regulation of telomere maintenance (GO:0032205)3.24118347
41poly(A)+ mRNA export from nucleus (GO:0016973)3.22854420
42intestinal cholesterol absorption (GO:0030299)3.20402632
43regulation of cholesterol homeostasis (GO:2000188)3.20267449
44kidney morphogenesis (GO:0060993)3.13636682
45establishment or maintenance of monopolar cell polarity (GO:0061339)3.11423668
46establishment of monopolar cell polarity (GO:0061162)3.11423668
47face development (GO:0060324)3.06213602
48DNA strand renaturation (GO:0000733)3.05364137
49anatomical structure regression (GO:0060033)3.02163736
50embryonic camera-type eye development (GO:0031076)3.01279224
51regulation of translational fidelity (GO:0006450)3.00731048
52regulation of sister chromatid cohesion (GO:0007063)3.00412015
53embryonic retina morphogenesis in camera-type eye (GO:0060059)2.99203570
54detection of light stimulus involved in sensory perception (GO:0050962)2.97753573
55detection of light stimulus involved in visual perception (GO:0050908)2.97753573
56neural tube formation (GO:0001841)2.97429996
57negative regulation of systemic arterial blood pressure (GO:0003085)2.96059628
58cilium organization (GO:0044782)2.95976082
59regulation of RNA export from nucleus (GO:0046831)2.93866416
60very-low-density lipoprotein particle assembly (GO:0034379)2.92614063
61positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.91502282
62histone H3-K9 methylation (GO:0051567)2.91283360
63interkinetic nuclear migration (GO:0022027)2.91229779
64apoptotic process involved in morphogenesis (GO:0060561)2.90703659
65response to pheromone (GO:0019236)2.89500483
66RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.87404351
67nonmotile primary cilium assembly (GO:0035058)2.87118038
68hindbrain development (GO:0030902)2.86341350
69regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.86231246
70positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.86231246
71mitotic G1 DNA damage checkpoint (GO:0031571)2.86090154
72DNA topological change (GO:0006265)2.84269668
73cytoplasmic mRNA processing body assembly (GO:0033962)2.84256975
74cilium assembly (GO:0042384)2.83422059
75regulation of protein homooligomerization (GO:0032462)2.82586686
76indole-containing compound metabolic process (GO:0042430)2.82384875
77histone H4-K12 acetylation (GO:0043983)2.79179535
78embryonic eye morphogenesis (GO:0048048)2.77800623
79convergent extension (GO:0060026)2.77476345
80kinetochore assembly (GO:0051382)2.77381275
81cell proliferation in forebrain (GO:0021846)2.75168455
82meiotic chromosome segregation (GO:0045132)2.75096861
83L-phenylalanine metabolic process (GO:0006558)2.74774588
84erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.74774588
85neuronal action potential (GO:0019228)2.74680646
86DNA deamination (GO:0045006)2.73325040
87ubiquinone biosynthetic process (GO:0006744)2.73152617
88trophectodermal cell differentiation (GO:0001829)2.72698766
89regulation of hippo signaling (GO:0035330)2.71801420
90heme transport (GO:0015886)2.71498492
91keratinization (GO:0031424)2.71275618
92mitotic G1/S transition checkpoint (GO:0044819)2.69575376
93positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.69260458
94positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.69260458
95positive regulation of mitotic sister chromatid separation (GO:1901970)2.69260458
96somite development (GO:0061053)2.68973315
97detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.67686923
98recombinational repair (GO:0000725)2.67191263
99somatic diversification of immune receptors via somatic mutation (GO:0002566)2.67152096
100somatic hypermutation of immunoglobulin genes (GO:0016446)2.67152096
101glyoxylate metabolic process (GO:0046487)2.66560864
102sulfation (GO:0051923)2.66097026
103negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.65829335
104double-strand break repair via homologous recombination (GO:0000724)2.65639475
105paraxial mesoderm development (GO:0048339)2.65304209
106reciprocal DNA recombination (GO:0035825)2.64742332
107reciprocal meiotic recombination (GO:0007131)2.64742332
108ubiquinone metabolic process (GO:0006743)2.64171350
109negative regulation of mRNA processing (GO:0050686)2.63572622
110G1 DNA damage checkpoint (GO:0044783)2.62851743
111mRNA cleavage (GO:0006379)2.62644492
112photoreceptor cell maintenance (GO:0045494)2.62129715
113dosage compensation (GO:0007549)2.60588119
114cilium morphogenesis (GO:0060271)2.60210208
115negative regulation of transcription regulatory region DNA binding (GO:2000678)2.60151400
116kinetochore organization (GO:0051383)2.59928029
117behavioral response to ethanol (GO:0048149)2.58479385
118water-soluble vitamin biosynthetic process (GO:0042364)2.57477975
119cellular response to ATP (GO:0071318)2.57432946
120regulation of stem cell maintenance (GO:2000036)2.57034815
121regulation of cilium movement (GO:0003352)2.56811493
122positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.55783289
123regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.55783289
124negative regulation of DNA-dependent DNA replication (GO:2000104)2.53076966
125amine catabolic process (GO:0009310)2.52455114
126cellular biogenic amine catabolic process (GO:0042402)2.52455114
127positive regulation of mRNA catabolic process (GO:0061014)2.52397724
128ncRNA catabolic process (GO:0034661)2.50488826
129microtubule polymerization or depolymerization (GO:0031109)2.50089849
130piRNA metabolic process (GO:0034587)2.49869587
131drug catabolic process (GO:0042737)2.49438682
132axonemal dynein complex assembly (GO:0070286)2.49362716
133pyrimidine nucleobase catabolic process (GO:0006208)2.49192561
134base-excision repair (GO:0006284)2.48891412
135regulation of gene silencing by RNA (GO:0060966)2.48561393
136regulation of posttranscriptional gene silencing (GO:0060147)2.48561393
137regulation of gene silencing by miRNA (GO:0060964)2.48561393
138negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.48101358
139cellular response to zinc ion (GO:0071294)2.47320760
140L-phenylalanine catabolic process (GO:0006559)2.46906263
141erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.46906263
142DNA demethylation (GO:0080111)2.46009557
143nodal signaling pathway (GO:0038092)2.44445148
144exogenous drug catabolic process (GO:0042738)2.43881039
145positive regulation of mRNA 3-end processing (GO:0031442)2.43504464
146positive regulation of mRNA processing (GO:0050685)2.43439194
147alkaloid metabolic process (GO:0009820)2.43386617
148centriole replication (GO:0007099)2.41750805
149protein-cofactor linkage (GO:0018065)2.40920811
150retinal cone cell development (GO:0046549)2.37279488
151negative regulation of fatty acid metabolic process (GO:0045922)2.37243215
152microtubule anchoring (GO:0034453)2.36786909
153intraciliary transport (GO:0042073)2.35908161
154hypotonic response (GO:0006971)2.35849649
155anterior/posterior axis specification, embryo (GO:0008595)2.34374091
156cellular response to exogenous dsRNA (GO:0071360)2.33626212
157cornea development in camera-type eye (GO:0061303)2.33326046
158positive regulation of sodium ion transmembrane transport (GO:1902307)2.32971593
159cellular ketone body metabolic process (GO:0046950)2.32917476
160embryonic camera-type eye morphogenesis (GO:0048596)2.32898665
161protein localization to cilium (GO:0061512)2.32558044
162quinone biosynthetic process (GO:1901663)2.32367655
163reflex (GO:0060004)2.32173370
164negative regulation of chondrocyte differentiation (GO:0032331)2.31838137
165maturation of 5.8S rRNA (GO:0000460)2.31459621
166hippo signaling (GO:0035329)2.30988098
167spinal cord motor neuron differentiation (GO:0021522)2.30938346
168DNA integration (GO:0015074)2.30660692
169methionine biosynthetic process (GO:0009086)2.30516523
170positive regulation of mRNA metabolic process (GO:1903313)2.30503247
171positive regulation of protein oligomerization (GO:0032461)2.29867029
172DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.28555276
173aromatic amino acid family catabolic process (GO:0009074)2.28401350
174regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.27406262
175negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.24644194
176triglyceride homeostasis (GO:0070328)2.24431676
177acylglycerol homeostasis (GO:0055090)2.24431676
178negative regulation of mRNA metabolic process (GO:1903312)2.24081240
179kynurenine metabolic process (GO:0070189)2.22639878
180intracellular estrogen receptor signaling pathway (GO:0030520)2.21391529
181plasma lipoprotein particle assembly (GO:0034377)2.21389875
182telomere maintenance via semi-conservative replication (GO:0032201)2.21382009
183lateral sprouting from an epithelium (GO:0060601)2.21343900
184positive regulation of developmental pigmentation (GO:0048087)2.20088839
185glomerular basement membrane development (GO:0032836)2.19894474
186protein localization to endosome (GO:0036010)2.18675249
187negative regulation of stress fiber assembly (GO:0051497)2.17962523
188glandular epithelial cell development (GO:0002068)2.17577349
189L-ascorbic acid metabolic process (GO:0019852)2.17101520
190pre-miRNA processing (GO:0031054)2.15810177
191formation of translation preinitiation complex (GO:0001731)2.15568698

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.24287304
2VDR_22108803_ChIP-Seq_LS180_Human3.36646604
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.28427185
4E2F7_22180533_ChIP-Seq_HELA_Human3.09520933
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.02129803
6EZH2_22144423_ChIP-Seq_EOC_Human2.98471663
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.96586170
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.71674239
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.69604041
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.63947658
11GBX2_23144817_ChIP-Seq_PC3_Human2.53947478
12FUS_26573619_Chip-Seq_HEK293_Human2.52438841
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.49884685
14EWS_26573619_Chip-Seq_HEK293_Human2.48591122
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.46181044
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40892974
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.33980976
18IGF1R_20145208_ChIP-Seq_DFB_Human2.33091316
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.31895828
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.31895828
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.31895828
22LXR_22158963_ChIP-Seq_LIVER_Mouse2.28914759
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27199438
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23290640
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.19194741
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.17963952
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.13872723
28TAF15_26573619_Chip-Seq_HEK293_Human2.13815785
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10212827
30VDR_21846776_ChIP-Seq_THP-1_Human2.04660073
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03507735
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.03153614
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.01517387
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.99031165
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.93997183
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91871973
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86545822
38P300_19829295_ChIP-Seq_ESCs_Human1.85240507
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84169605
40AR_21572438_ChIP-Seq_LNCaP_Human1.80969475
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79877812
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77344338
43NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.76754655
44MYC_22102868_ChIP-Seq_BL_Human1.74787520
45TCF3_18692474_ChIP-Seq_MEFs_Mouse1.74010666
46SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.73618074
47ER_23166858_ChIP-Seq_MCF-7_Human1.73535563
48* STAT3_23295773_ChIP-Seq_U87_Human1.71577012
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70404920
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.70404920
51TCF3_18692474_ChIP-Seq_MESCs_Mouse1.66409208
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.66132825
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.63682882
54IRF1_19129219_ChIP-ChIP_H3396_Human1.62698485
55CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.60496161
56RACK7_27058665_Chip-Seq_MCF-7_Human1.60236595
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60234073
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.58867705
59FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.57376626
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57070596
61* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.55900827
62CBP_20019798_ChIP-Seq_JUKART_Human1.55669008
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55669008
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54584326
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54207128
66SMAD4_21799915_ChIP-Seq_A2780_Human1.53832405
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53722440
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.53183246
69* TCF4_23295773_ChIP-Seq_U87_Human1.52177821
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50009588
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.49363687
72* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.49095024
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48524341
74MYC_18940864_ChIP-ChIP_HL60_Human1.46500282
75RNF2_27304074_Chip-Seq_NSC_Mouse1.46227040
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.46158648
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45960693
78AR_25329375_ChIP-Seq_VCAP_Human1.45783555
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44561456
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44178110
81LXR_22292898_ChIP-Seq_THP-1_Human1.42993950
82* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42761137
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42202425
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.41725340
85MYC_18555785_ChIP-Seq_MESCs_Mouse1.41267719
86AR_21909140_ChIP-Seq_LNCAP_Human1.40889657
87EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39020129
88NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.38333546
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36194988
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35327416
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34939716
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34795306
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34119038
94CDX2_20551321_ChIP-Seq_CACO-2_Human1.34058054
95* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.33961962
96BCAT_22108803_ChIP-Seq_LS180_Human1.33370827
97ZNF263_19887448_ChIP-Seq_K562_Human1.33141651
98NANOG_21062744_ChIP-ChIP_HESCs_Human1.32698980
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32406903
100* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31491909
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.31375338
102* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31119801
103EST1_17652178_ChIP-ChIP_JURKAT_Human1.30734505
104PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29330070
105TP63_19390658_ChIP-ChIP_HaCaT_Human1.28860108
106TCF4_22108803_ChIP-Seq_LS180_Human1.28831690
107GATA6_25053715_ChIP-Seq_YYC3_Human1.27902786
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27898160
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27450769
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.27162418
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27132853
112ESR1_21235772_ChIP-Seq_MCF-7_Human1.26518437
113HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26491219
114TCF7_22412390_ChIP-Seq_EML_Mouse1.26484399
115ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25846400
116RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24966753
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23976776
118RUNX2_22187159_ChIP-Seq_PCA_Human1.22609636
119CLOCK_20551151_ChIP-Seq_293T_Human1.21801558
120* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21272849
121KDM2B_26808549_Chip-Seq_DND41_Human1.20785509
122TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20479364
123TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20124909
124EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19904521
125* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18718225
126ESR2_21235772_ChIP-Seq_MCF-7_Human1.17419165
127EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.15283960
128TP53_16413492_ChIP-PET_HCT116_Human1.13579522
129CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13532391
130* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13401029
131PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12475822
132KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12282316
133NANOG_19829295_ChIP-Seq_ESCs_Human1.11960602
134SOX2_19829295_ChIP-Seq_ESCs_Human1.11960602
135KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11871433
136TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11651452
137SMAD4_21741376_ChIP-Seq_EPCs_Human1.10782764
138CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10464059
139EGR1_19374776_ChIP-ChIP_THP-1_Human1.10378362
140EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09997084
141NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.09848203
142SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09410247
143* TP53_22573176_ChIP-Seq_HFKS_Human1.09249609
144AR_20517297_ChIP-Seq_VCAP_Human1.08685308
145DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08144905
146ATF3_27146783_Chip-Seq_COLON_Human1.07101525
147NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06950465
148SOX2_18692474_ChIP-Seq_MEFs_Mouse1.06354797
149* ETV1_20927104_ChIP-Seq_GIST48_Human1.05912965
150PRDM14_20953172_ChIP-Seq_ESCs_Human1.04602901
151NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04387726
152ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04385255
153NCOR1_26117541_ChIP-Seq_K562_Human1.04261258
154SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04162302
155* NFYB_21822215_ChIP-Seq_K562_Human1.04121885
156RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03489311
157FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02169942
158FOXA1_25329375_ChIP-Seq_VCAP_Human1.02169942
159REST_21632747_ChIP-Seq_MESCs_Mouse1.01779099
160NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01672379
161* HOXB7_26014856_ChIP-Seq_BT474_Human1.01245777
162STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01112441
163TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00842914
164CHD1_26751641_Chip-Seq_LNCaP_Human1.00346551
165POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00301329
166SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99189495
167SOX2_18692474_ChIP-Seq_MESCs_Mouse0.99013295
168GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98483592
169TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98274256
170* TBL1_22424771_ChIP-Seq_293T_Human0.98201262
171FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97481308
172FLI1_21867929_ChIP-Seq_TH2_Mouse0.97393472
173EZH2_27294783_Chip-Seq_NPCs_Mouse0.96601710
174NANOG_18692474_ChIP-Seq_MESCs_Mouse0.96597009
175NFE2_27457419_Chip-Seq_LIVER_Mouse0.96368838
176* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96099159
177* PHF8_20622853_ChIP-Seq_HELA_Human0.96008501
178NCOR_22424771_ChIP-Seq_293T_Human0.95917648
179SALL1_21062744_ChIP-ChIP_HESCs_Human0.95898885
180E2F4_17652178_ChIP-ChIP_JURKAT_Human0.95564956
181ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95437484
182SOX2_21211035_ChIP-Seq_LN229_Gbm0.95242226
183RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94745346
184CDX2_22108803_ChIP-Seq_LS180_Human0.94686411
185SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94453266
186NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94064406
187EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93964193
188FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93556407
189GATA3_21878914_ChIP-Seq_MCF-7_Human0.93483409
190PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93328861
191E2F1_21310950_ChIP-Seq_MCF-7_Human0.92769262
192EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92757687
193* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.92257899
194ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91112049
195MAF_26560356_Chip-Seq_TH1_Human0.90660657

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.34892687
2MP0006292_abnormal_olfactory_placode3.20358592
3MP0010030_abnormal_orbit_morphology3.04877453
4MP0003195_calcinosis2.94750083
5MP0009278_abnormal_bone_marrow2.70294985
6MP0004043_abnormal_pH_regulation2.62768668
7MP0005360_urolithiasis2.55326649
8MP0005085_abnormal_gallbladder_physiolo2.51617128
9MP0005365_abnormal_bile_salt2.48441638
10MP0003646_muscle_fatigue2.40178633
11MP0008877_abnormal_DNA_methylation2.36995728
12MP0000383_abnormal_hair_follicle2.19938507
13MP0002139_abnormal_hepatobiliary_system2.13989998
14MP0002938_white_spotting2.09314598
15MP0008058_abnormal_DNA_repair2.04224339
16MP0003705_abnormal_hypodermis_morpholog1.99147828
17MP0003787_abnormal_imprinting1.99041816
18MP0002102_abnormal_ear_morphology1.94592198
19MP0005551_abnormal_eye_electrophysiolog1.92022502
20MP0000631_abnormal_neuroendocrine_gland1.90595840
21MP0010352_gastrointestinal_tract_polyps1.87551802
22MP0000569_abnormal_digit_pigmentation1.78994880
23MP0002009_preneoplasia1.78632020
24MP0004885_abnormal_endolymph1.77256228
25MP0006072_abnormal_retinal_apoptosis1.76249132
26MP0005171_absent_coat_pigmentation1.74920957
27MP0005076_abnormal_cell_differentiation1.70968918
28MP0004233_abnormal_muscle_weight1.68010123
29MP0004264_abnormal_extraembryonic_tissu1.66841919
30MP0003718_maternal_effect1.65547054
31MP0001501_abnormal_sleep_pattern1.64972598
32MP0003453_abnormal_keratinocyte_physiol1.62300469
33MP0009053_abnormal_anal_canal1.61600022
34MP0008995_early_reproductive_senescence1.60684250
35MP0005646_abnormal_pituitary_gland1.59916106
36MP0002249_abnormal_larynx_morphology1.58734121
37MP0001485_abnormal_pinna_reflex1.58182931
38MP0008961_abnormal_basal_metabolism1.57640639
39MP0005253_abnormal_eye_physiology1.55324997
40MP0002736_abnormal_nociception_after1.54113437
41MP0001968_abnormal_touch/_nociception1.53449737
42MP0003937_abnormal_limbs/digits/tail_de1.52555580
43MP0008872_abnormal_physiological_respon1.52149036
44MP0003567_abnormal_fetal_cardiomyocyte1.51381017
45MP0005397_hematopoietic_system_phenotyp1.51168571
46MP0001545_abnormal_hematopoietic_system1.51168571
47MP0003806_abnormal_nucleotide_metabolis1.50682615
48MP0003890_abnormal_embryonic-extraembry1.46613008
49MP0000427_abnormal_hair_cycle1.45920604
50MP0004142_abnormal_muscle_tone1.45841843
51MP0009840_abnormal_foam_cell1.43895728
52MP0003252_abnormal_bile_duct1.42107707
53MP0000049_abnormal_middle_ear1.41493253
54MP0010368_abnormal_lymphatic_system1.41276663
55MP0001293_anophthalmia1.36615317
56MP0009046_muscle_twitch1.36382483
57MP0010094_abnormal_chromosome_stability1.35955312
58MP0002086_abnormal_extraembryonic_tissu1.35898658
59MP0000778_abnormal_nervous_system1.35007696
60MP0010678_abnormal_skin_adnexa1.33054041
61MP0002876_abnormal_thyroid_physiology1.32159499
62MP0002282_abnormal_trachea_morphology1.31682551
63MP0003693_abnormal_embryo_hatching1.30899664
64MP0000579_abnormal_nail_morphology1.30212597
65MP0003119_abnormal_digestive_system1.29588153
66MP0008875_abnormal_xenobiotic_pharmacok1.28621755
67MP0004147_increased_porphyrin_level1.27773897
68MP0000647_abnormal_sebaceous_gland1.24207983
69MP0003566_abnormal_cell_adhesion1.23782179
70MP0004197_abnormal_fetal_growth/weight/1.23755144
71* MP0001672_abnormal_embryogenesis/_devel1.23199938
72* MP0005380_embryogenesis_phenotype1.23199938
73MP0003121_genomic_imprinting1.22049406
74MP0002084_abnormal_developmental_patter1.21834415
75MP0009697_abnormal_copulation1.21208562
76MP0003984_embryonic_growth_retardation1.21107067
77MP0001697_abnormal_embryo_size1.18584881
78MP0002088_abnormal_embryonic_growth/wei1.16854310
79MP0002928_abnormal_bile_duct1.16779941
80MP0003878_abnormal_ear_physiology1.16251802
81MP0005377_hearing/vestibular/ear_phenot1.16251802
82MP0002557_abnormal_social/conspecific_i1.15745315
83MP0003828_pulmonary_edema1.15668738
84MP0002060_abnormal_skin_morphology1.15580131
85MP0002796_impaired_skin_barrier1.14811659
86MP0006276_abnormal_autonomic_nervous1.13798462
87MP0000462_abnormal_digestive_system1.13593275
88MP0010630_abnormal_cardiac_muscle1.13314413
89* MP0002085_abnormal_embryonic_tissue1.13055121
90MP0001984_abnormal_olfaction1.12627213
91MP0000762_abnormal_tongue_morphology1.09841468
92MP0002234_abnormal_pharynx_morphology1.08933502
93MP0002653_abnormal_ependyma_morphology1.08704332
94MP0003938_abnormal_ear_development1.08274574
95MP0005023_abnormal_wound_healing1.07089011
96MP0000516_abnormal_urinary_system1.06689658
97MP0005367_renal/urinary_system_phenotyp1.06689658
98MP0002160_abnormal_reproductive_system1.05064896
99MP0003656_abnormal_erythrocyte_physiolo1.04995908
100MP0003935_abnormal_craniofacial_develop1.04752392
101MP0002932_abnormal_joint_morphology1.04625705
102MP0001730_embryonic_growth_arrest1.04382351
103* MP0005195_abnormal_posterior_eye1.03383737
104MP0004019_abnormal_vitamin_homeostasis1.03242288
105MP0004957_abnormal_blastocyst_morpholog1.02320516
106MP0000490_abnormal_crypts_of1.02023034
107MP0003111_abnormal_nucleus_morphology1.01338934
108MP0005389_reproductive_system_phenotype1.00204690
109MP0002095_abnormal_skin_pigmentation0.99570797
110MP0002210_abnormal_sex_determination0.98537179
111MP0002098_abnormal_vibrissa_morphology0.98399306
112MP0001915_intracranial_hemorrhage0.97767509
113MP0001666_abnormal_nutrient_absorption0.97628540
114MP0003698_abnormal_male_reproductive0.97419241
115MP0005501_abnormal_skin_physiology0.97151471
116MP0001188_hyperpigmentation0.95796433
117MP0001486_abnormal_startle_reflex0.95283670
118* MP0001286_abnormal_eye_development0.94916233
119MP0003786_premature_aging0.94858981
120MP0005248_abnormal_Harderian_gland0.92360468
121MP0000470_abnormal_stomach_morphology0.90247589
122MP0003283_abnormal_digestive_organ0.89828991
123* MP0003861_abnormal_nervous_system0.89622230
124MP0005645_abnormal_hypothalamus_physiol0.89606124
125MP0000026_abnormal_inner_ear0.89558229
126MP0001529_abnormal_vocalization0.89485694
127MP0009745_abnormal_behavioral_response0.89358669
128MP0002733_abnormal_thermal_nociception0.88705118
129MP0005174_abnormal_tail_pigmentation0.87987665
130MP0001929_abnormal_gametogenesis0.87646367
131MP0005448_abnormal_energy_balance0.87604582
132MP0001919_abnormal_reproductive_system0.87390339
133MP0002735_abnormal_chemical_nociception0.87227181
134MP0002111_abnormal_tail_morphology0.87198016
135MP0005508_abnormal_skeleton_morphology0.87095795
136MP0002752_abnormal_somatic_nervous0.86998062
137MP0005386_behavior/neurological_phenoty0.86568240
138MP0004924_abnormal_behavior0.86568240
139* MP0003077_abnormal_cell_cycle0.86494139
140MP0000432_abnormal_head_morphology0.86437129
141MP0000609_abnormal_liver_physiology0.85559374
142MP0002925_abnormal_cardiovascular_devel0.85078506
143MP0003122_maternal_imprinting0.84114240
144MP0000350_abnormal_cell_proliferation0.83901714
145MP0005391_vision/eye_phenotype0.83387075
146MP0001879_abnormal_lymphatic_vessel0.83287156
147MP0004742_abnormal_vestibular_system0.82742291
148MP0003136_yellow_coat_color0.82331774
149MP0005332_abnormal_amino_acid0.81971304
150MP0000653_abnormal_sex_gland0.81573068
151MP0002138_abnormal_hepatobiliary_system0.81490675
152MP0000230_abnormal_systemic_arterial0.81260204
153MP0003943_abnormal_hepatobiliary_system0.80759794
154MP0005187_abnormal_penis_morphology0.80675470
155MP0002092_abnormal_eye_morphology0.79832900
156MP0002572_abnormal_emotion/affect_behav0.79587224
157MP0002697_abnormal_eye_size0.79221566
158MP0002877_abnormal_melanocyte_morpholog0.79043329
159MP0001145_abnormal_male_reproductive0.77586009
160MP0001502_abnormal_circadian_rhythm0.77078086
161MP0003941_abnormal_skin_development0.76560016
162MP0003755_abnormal_palate_morphology0.76535857
163MP0004145_abnormal_muscle_electrophysio0.76158761
164MP0003191_abnormal_cellular_cholesterol0.76111292
165MP0005330_cardiomyopathy0.76023974
166MP0004272_abnormal_basement_membrane0.74846038
167MP0005266_abnormal_metabolism0.74844408
168MP0002109_abnormal_limb_morphology0.74405523
169MP0009115_abnormal_fat_cell0.73874120
170MP0004133_heterotaxia0.73831409
171MP0000598_abnormal_liver_morphology0.73243613
172MP0008932_abnormal_embryonic_tissue0.73089620
173MP0000266_abnormal_heart_morphology0.72886263
174MP0010329_abnormal_lipoprotein_level0.72768502
175* MP0002080_prenatal_lethality0.72346109
176MP0000566_synostosis0.70404113
177MP0000733_abnormal_muscle_development0.70138505
178MP0000537_abnormal_urethra_morphology0.69935513
179MP0000477_abnormal_intestine_morphology0.69830113
180MP0001340_abnormal_eyelid_morphology0.69789395
181MP0002269_muscular_atrophy0.69236020
182MP0002019_abnormal_tumor_incidence0.67224247
183MP0000467_abnormal_esophagus_morphology0.67119955

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.53478732
2Pancreatic fibrosis (HP:0100732)4.25110924
3True hermaphroditism (HP:0010459)4.17296651
4Hypochromic microcytic anemia (HP:0004840)4.09281114
5Rib fusion (HP:0000902)3.88527683
6Nephronophthisis (HP:0000090)3.81176566
7Abnormality of midbrain morphology (HP:0002418)3.61183082
8Molar tooth sign on MRI (HP:0002419)3.61183082
9Turricephaly (HP:0000262)3.56010613
10Coronal craniosynostosis (HP:0004440)3.54568897
11Ulnar bowing (HP:0003031)3.51370339
12Pustule (HP:0200039)3.48754380
13Chronic hepatic failure (HP:0100626)3.46104133
14Genetic anticipation (HP:0003743)3.33983116
15Abnormality of the renal medulla (HP:0100957)3.33837103
16Hyperventilation (HP:0002883)3.31444547
17Alopecia of scalp (HP:0002293)3.23805034
18Cystic liver disease (HP:0006706)3.22612431
19Pancreatic islet-cell hyperplasia (HP:0004510)3.20898545
20Rectal fistula (HP:0100590)3.05121108
21Rectovaginal fistula (HP:0000143)3.05121108
22Vaginal fistula (HP:0004320)3.03793406
23Facial hemangioma (HP:0000329)3.03692684
24Absent/shortened dynein arms (HP:0200106)3.00461082
25Dynein arm defect of respiratory motile cilia (HP:0012255)3.00461082
26Intestinal fistula (HP:0100819)3.00299276
27Polycythemia (HP:0001901)2.98510074
28Congenital stationary night blindness (HP:0007642)2.97203256
29Intrahepatic cholestasis (HP:0001406)2.96522092
30Tubular atrophy (HP:0000092)2.91542466
31Patellar aplasia (HP:0006443)2.89800547
32Abnormal hemoglobin (HP:0011902)2.83836541
33Decreased circulating renin level (HP:0003351)2.79384178
34Aplasia/Hypoplasia of the patella (HP:0006498)2.78421376
35Diaphragmatic weakness (HP:0009113)2.72988461
36Abnormality of the labia minora (HP:0012880)2.67477988
37Anencephaly (HP:0002323)2.66194936
38Type II lissencephaly (HP:0007260)2.65794891
39Volvulus (HP:0002580)2.64499243
40Concave nail (HP:0001598)2.62522548
41Abnormality of the renal cortex (HP:0011035)2.60305938
42Short humerus (HP:0005792)2.59456279
43Birth length less than 3rd percentile (HP:0003561)2.55071356
44Medial flaring of the eyebrow (HP:0010747)2.53451020
45Aplasia/Hypoplasia of the tongue (HP:0010295)2.52049813
46Vertebral hypoplasia (HP:0008417)2.50256458
47Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.50256458
48Abnormality of monocarboxylic acid metabolism (HP:0010996)2.49360246
49Myocardial infarction (HP:0001658)2.49206520
50Attenuation of retinal blood vessels (HP:0007843)2.47538986
51Abnormal respiratory motile cilium morphology (HP:0005938)2.45898258
52Abnormal respiratory epithelium morphology (HP:0012253)2.45898258
53Sclerocornea (HP:0000647)2.44003127
54Aplasia/hypoplasia of the humerus (HP:0006507)2.42589146
55Furrowed tongue (HP:0000221)2.41167166
56Pendular nystagmus (HP:0012043)2.39160927
57Deep venous thrombosis (HP:0002625)2.38232082
58Abnormality of aromatic amino acid family metabolism (HP:0004338)2.37720862
59Poikiloderma (HP:0001029)2.35002091
60Abnormal biliary tract physiology (HP:0012439)2.34993685
61Bile duct proliferation (HP:0001408)2.34993685
62Aplasia of the musculature (HP:0100854)2.31511972
63Anteriorly placed anus (HP:0001545)2.31256009
64Short 5th finger (HP:0009237)2.30968079
65Premature skin wrinkling (HP:0100678)2.30844013
66Abnormality of the pons (HP:0007361)2.30748173
67Absent radius (HP:0003974)2.29291462
68Lissencephaly (HP:0001339)2.29042952
69Selective tooth agenesis (HP:0001592)2.28256885
70Muscle fibrillation (HP:0010546)2.27385416
71Partial agenesis of the corpus callosum (HP:0001338)2.27163292
72Progressive cerebellar ataxia (HP:0002073)2.27038579
73Male infertility (HP:0003251)2.24420625
74Protruding tongue (HP:0010808)2.23794092
75Congenital hepatic fibrosis (HP:0002612)2.23682894
76Cerebellar dysplasia (HP:0007033)2.23090040
77Postaxial foot polydactyly (HP:0001830)2.20462128
78Metaphyseal cupping (HP:0003021)2.18474048
79Abnormality of the pancreatic islet cells (HP:0006476)2.18053185
80Abnormality of endocrine pancreas physiology (HP:0012093)2.18053185
81Abolished electroretinogram (ERG) (HP:0000550)2.17063835
82Intestinal atresia (HP:0011100)2.16963743
83Hypobetalipoproteinemia (HP:0003563)2.15694911
84Hypoplasia of the pons (HP:0012110)2.12098582
85Tongue fasciculations (HP:0001308)2.11729007
86Abnormal ciliary motility (HP:0012262)2.11073229
87Bilateral microphthalmos (HP:0007633)2.11010412
88Abnormality of the fingertips (HP:0001211)2.10119740
89Gaze-evoked nystagmus (HP:0000640)2.09857508
90Dandy-Walker malformation (HP:0001305)2.07630382
91Absent forearm bone (HP:0003953)2.05512252
92Aplasia involving forearm bones (HP:0009822)2.05512252
93Preaxial hand polydactyly (HP:0001177)2.05145402
94Large for gestational age (HP:0001520)2.03826889
95Esophageal varix (HP:0002040)2.03774742
96Abnormality of male internal genitalia (HP:0000022)2.03635110
97Chronic bronchitis (HP:0004469)2.03118985
98Bowed forearm bones (HP:0003956)2.02825034
99Bowing of the arm (HP:0006488)2.02825034
100Clumsiness (HP:0002312)2.02223739
101Polydipsia (HP:0001959)2.01907021
102Abnormal drinking behavior (HP:0030082)2.01907021
103Capillary hemangiomas (HP:0005306)2.01156989
104Bony spicule pigmentary retinopathy (HP:0007737)2.00935920
105Male pseudohermaphroditism (HP:0000037)1.99307252
106Broad-based gait (HP:0002136)1.98509279
107Abnormal respiratory motile cilium physiology (HP:0012261)1.98277196
108Occipital encephalocele (HP:0002085)1.98118474
109Abnormality of the aortic arch (HP:0012303)1.97939974
110Hypotrichosis (HP:0001006)1.97489159
111Hypochromic anemia (HP:0001931)1.96656655
112Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.95980129
113Aplasia/Hypoplasia of the sternum (HP:0006714)1.94995687
114Hypoplastic labia majora (HP:0000059)1.94436463
115Gait imbalance (HP:0002141)1.94172686
116Anophthalmia (HP:0000528)1.94036660
117Shawl scrotum (HP:0000049)1.93073290
118Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.92814982
119Vertebral fusion (HP:0002948)1.92737061
120Annular pancreas (HP:0001734)1.91514619
121Poor coordination (HP:0002370)1.91449439
122Increased number of teeth (HP:0011069)1.91291377
123Fat malabsorption (HP:0002630)1.91214042
124Fair hair (HP:0002286)1.91049189
125Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.91006195
126Genital tract atresia (HP:0001827)1.90189600
127Lip pit (HP:0100267)1.89810439
128Right ventricular cardiomyopathy (HP:0011663)1.89790057
129Broad hallux (HP:0010055)1.89704577
130Congenital primary aphakia (HP:0007707)1.89516106
131Thyroid-stimulating hormone excess (HP:0002925)1.88853326
132Hypoglycemic coma (HP:0001325)1.87101785
133Alacrima (HP:0000522)1.85948005
134Cerebral aneurysm (HP:0004944)1.84606497
135Broad toe (HP:0001837)1.84104995
136Vaginal atresia (HP:0000148)1.83900823
137Broad thumb (HP:0011304)1.82984488
138Xanthomatosis (HP:0000991)1.82665776
139Abnormality of the nasal septum (HP:0000419)1.82586312
140Hypoplastic ischia (HP:0003175)1.82131181
141Chorioretinal atrophy (HP:0000533)1.82034148
142Abnormality of the renal collecting system (HP:0004742)1.81908260
143Rectal prolapse (HP:0002035)1.80724663
144Orthostatic hypotension (HP:0001278)1.77341409
145Sloping forehead (HP:0000340)1.77000060
146Generalized amyotrophy (HP:0003700)1.76620590
147Nephrogenic diabetes insipidus (HP:0009806)1.76058824
148Abnormality of the labia majora (HP:0012881)1.75765551
149Abnormality of the hepatic vasculature (HP:0006707)1.75352850
150Ectopic kidney (HP:0000086)1.75160138
151Choanal stenosis (HP:0000452)1.74807676
152Pseudobulbar signs (HP:0002200)1.74660868
153Depressed nasal tip (HP:0000437)1.74542348
154Optic nerve hypoplasia (HP:0000609)1.74085008
155Broad alveolar ridges (HP:0000187)1.73036108
156Inability to walk (HP:0002540)1.71578117
157Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71329028
158Abnormality of pyrimidine metabolism (HP:0004353)1.70789570
159Neoplasm of the oral cavity (HP:0100649)1.70661755
160Aplasia/Hypoplasia of the uvula (HP:0010293)1.70224398
161Aplasia/Hypoplasia of the tibia (HP:0005772)1.69961831
162Postaxial hand polydactyly (HP:0001162)1.68602654
163Increased mean platelet volume (HP:0011877)1.68463548
164Squamous cell carcinoma (HP:0002860)1.68266454
165Focal segmental glomerulosclerosis (HP:0000097)1.68263017
166Gastrointestinal atresia (HP:0002589)1.68154195
167Malnutrition (HP:0004395)1.67856221
168Polyuria (HP:0000103)1.67528098
169Supernumerary spleens (HP:0009799)1.66650150
170Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.66595650
171Short 4th metacarpal (HP:0010044)1.66595650
172Pachygyria (HP:0001302)1.65860604
173Keratoconus (HP:0000563)1.65729365
174Increased corneal curvature (HP:0100692)1.65729365
175Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.65455171
176Abnormality of alanine metabolism (HP:0010916)1.65455171
177Hyperalaninemia (HP:0003348)1.65455171
178Albinism (HP:0001022)1.65054878
179Congenital hip dislocation (HP:0001374)1.64900242
180Abnormality of glutamine family amino acid metabolism (HP:0010902)1.64377088
181Abnormality of homocysteine metabolism (HP:0010919)1.64246446
182Homocystinuria (HP:0002156)1.64246446
183Hamartoma (HP:0010566)1.64138845
184Stomach cancer (HP:0012126)1.63721098
185Abnormality of renin-angiotensin system (HP:0000847)1.63675380
186Oligodactyly (hands) (HP:0001180)1.63634161
187Preaxial foot polydactyly (HP:0001841)1.63551134
188Duplicated collecting system (HP:0000081)1.63419067
189Mesangial abnormality (HP:0001966)1.63036632
190Abnormal rod and cone electroretinograms (HP:0008323)1.62756619
191Meckel diverticulum (HP:0002245)1.61990295
192Tubulointerstitial nephritis (HP:0001970)1.61584218
193Steatorrhea (HP:0002570)1.61301533
194Abnormality of sulfur amino acid metabolism (HP:0004339)1.61084105
195Abnormality of the 4th metacarpal (HP:0010012)1.59730451
196Mucopolysacchariduria (HP:0008155)1.58894306
197Urinary glycosaminoglycan excretion (HP:0003541)1.58894306
198Split hand (HP:0001171)1.58440017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.48388254
2ICK4.46352826
3MAPK153.78087592
4DDR23.42714926
5BMPR1B2.92739440
6MAP3K62.91366592
7CDK122.88196625
8LATS12.83209153
9WNK32.53477285
10MKNK22.37726088
11ADRBK22.35993135
12TNIK2.27555609
13MKNK12.00873058
14ZAK1.97178223
15BMX1.96535582
16PDGFRA1.95664533
17MATK1.91651124
18CASK1.89289653
19DYRK1B1.87613866
20NUAK11.86026915
21CDK61.85419561
22CDK71.84530337
23INSRR1.81706954
24TRPM71.78333573
25TLK11.76876377
26MAP3K111.74133952
27MAP3K41.71922987
28MAP4K21.71549756
29MAP3K101.68779939
30PNCK1.68069947
31GRK11.66391326
32TYRO31.66094403
33SIK21.65328887
34CSK1.63672167
35STK31.56099230
36PRKD21.52693202
37PINK11.39478938
38MARK11.39039801
39CAMK1G1.38844388
40ERN11.35673588
41VRK21.33159574
42FGR1.33009942
43YES11.31574547
44PIM11.30698374
45PIM21.29171405
46MTOR1.28119928
47TRIM281.26850225
48EPHA21.26783230
49EPHB11.22080232
50MAPK131.21449197
51AKT31.19569780
52DYRK31.17464157
53MAPK111.16791128
54GSK3A1.15379680
55SIK11.14569031
56CDC71.12641876
57UHMK11.12298296
58PLK41.09260127
59STK101.07894415
60EPHB21.05879741
61VRK11.04976584
62CDC42BPA1.01552729
63TRIB31.01278156
64RPS6KC10.99769791
65RPS6KL10.99769791
66NME10.98732570
67RPS6KA60.94130742
68MUSK0.91629724
69NEK20.90585498
70STK390.89864307
71BCR0.89838640
72BRD40.89803886
73SRPK10.89271346
74BCKDK0.89056898
75STK38L0.88727676
76OXSR10.88003826
77DYRK20.86456553
78KDR0.86196792
79STK40.84433426
80IRAK10.83890307
81PRKCG0.83731012
82CDK40.83113453
83CHEK20.82939635
84PLK30.82911824
85LATS20.81223344
86TAF10.81145807
87FGFR40.80711461
88RPS6KB20.80499894
89CSNK1A1L0.79818250
90PIK3CA0.79742052
91WEE10.79008831
92MAP2K60.78368200
93DMPK0.78273134
94CHUK0.78062667
95SGK20.76950988
96BUB10.76046646
97HIPK20.75448521
98FGFR20.75403817
99PRKCE0.74468219
100ADRBK10.74153974
101TIE10.72900910
102MAP2K70.72718141
103PAK20.72225396
104TTK0.72010532
105PTK20.71642764
106ATR0.71386177
107TGFBR20.70533778
108PKN10.68739734
109RIPK10.67646047
110MAPKAPK30.67164645
111PAK40.66383829
112EPHA30.65313683
113PTK60.64865356
114TXK0.64286049
115TSSK60.63424346
116PDGFRB0.62178437
117PLK10.61985011
118CDK30.61328711
119RPS6KA40.61302501
120RPS6KA10.61255227
121MELK0.61249253
122NLK0.60810436
123TTN0.59383479
124MAPKAPK20.59220795
125TAOK30.57742158
126MAPK10.56636582
127MAPKAPK50.55642748
128CSNK1G10.55339950
129PRKAA20.55306728
130ERBB20.54889908
131AURKB0.54336680
132FLT30.53028302
133PRKAA10.52206563
134ACVR1B0.51975455
135CAMK1D0.51863300
136MET0.51403600
137PRKD10.50746093
138PAK30.50450023
139PBK0.50429313
140ERBB30.49242528
141CSNK1G30.49223206
142CDK80.48985409
143CDK20.48429286
144WNK10.47857068
145EIF2AK20.47654349
146ATM0.47591785
147CSNK1G20.47525858
148CSNK1E0.47118400
149EGFR0.46687791
150LRRK20.45189441
151NEK90.43929326
152DAPK10.43704307
153SGK2230.43676775
154SGK4940.43676775
155TGFBR10.43123259
156WNK40.42996325
157GRK70.42783838
158FGFR10.42131098
159CHEK10.41725063
160CDK10.41391031
161BRSK20.41223098
162MAPK30.41148812
163MAP3K80.40336106
164DAPK20.37573655
165GSK3B0.36765856
166MAP2K30.35870906
167PRKG20.35533708
168TAOK20.34066747

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005912.70871058
2Phototransduction_Homo sapiens_hsa047442.54564185
3Fatty acid biosynthesis_Homo sapiens_hsa000612.52560046
4RNA polymerase_Homo sapiens_hsa030202.43005348
5Mismatch repair_Homo sapiens_hsa034302.28674834
6Base excision repair_Homo sapiens_hsa034102.28007080
7Basal transcription factors_Homo sapiens_hsa030222.19153355
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.17862419
9Lysine degradation_Homo sapiens_hsa003102.17118814
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.13341843
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93498608
12Pentose and glucuronate interconversions_Homo sapiens_hsa000401.93408459
13DNA replication_Homo sapiens_hsa030301.90548547
14Nitrogen metabolism_Homo sapiens_hsa009101.86974370
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86569589
16Fatty acid metabolism_Homo sapiens_hsa012121.84896681
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.83704498
18Arginine and proline metabolism_Homo sapiens_hsa003301.80889057
19RNA degradation_Homo sapiens_hsa030181.80370980
20Arginine biosynthesis_Homo sapiens_hsa002201.76378812
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76250040
22Ether lipid metabolism_Homo sapiens_hsa005651.75323172
23Adherens junction_Homo sapiens_hsa045201.71784007
24Notch signaling pathway_Homo sapiens_hsa043301.69475101
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.69232074
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67452467
27Folate biosynthesis_Homo sapiens_hsa007901.66828224
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65278266
29Tryptophan metabolism_Homo sapiens_hsa003801.63706759
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55321039
31Fatty acid degradation_Homo sapiens_hsa000711.54626048
32Nicotine addiction_Homo sapiens_hsa050331.48676273
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37351082
34Hippo signaling pathway_Homo sapiens_hsa043901.34466420
35One carbon pool by folate_Homo sapiens_hsa006701.30878894
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28913170
37Taste transduction_Homo sapiens_hsa047421.27469416
38Biosynthesis of amino acids_Homo sapiens_hsa012301.26319052
39Selenocompound metabolism_Homo sapiens_hsa004501.24926856
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22668211
41Steroid biosynthesis_Homo sapiens_hsa001001.22600440
42TGF-beta signaling pathway_Homo sapiens_hsa043501.22042230
43Sulfur relay system_Homo sapiens_hsa041221.21825675
44Basal cell carcinoma_Homo sapiens_hsa052171.20692056
45Complement and coagulation cascades_Homo sapiens_hsa046101.20689382
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.19238640
47Histidine metabolism_Homo sapiens_hsa003401.18980841
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14673975
49Non-homologous end-joining_Homo sapiens_hsa034501.14338656
50Olfactory transduction_Homo sapiens_hsa047401.14240389
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10276126
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09956949
53Cell cycle_Homo sapiens_hsa041101.09182777
54Chemical carcinogenesis_Homo sapiens_hsa052041.08993877
55Bladder cancer_Homo sapiens_hsa052191.07290023
56Hedgehog signaling pathway_Homo sapiens_hsa043401.07134212
57Fat digestion and absorption_Homo sapiens_hsa049751.06889897
58Intestinal immune network for IgA production_Homo sapiens_hsa046721.06398632
59Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05205606
60p53 signaling pathway_Homo sapiens_hsa041151.04343342
61Starch and sucrose metabolism_Homo sapiens_hsa005001.02787211
62Arachidonic acid metabolism_Homo sapiens_hsa005901.02150676
63Propanoate metabolism_Homo sapiens_hsa006401.02023178
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01402381
65Fatty acid elongation_Homo sapiens_hsa000621.00851232
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00068525
67Dorso-ventral axis formation_Homo sapiens_hsa043200.99003704
68PPAR signaling pathway_Homo sapiens_hsa033200.98322964
69Caffeine metabolism_Homo sapiens_hsa002320.98179863
70Small cell lung cancer_Homo sapiens_hsa052220.97509183
71Glutathione metabolism_Homo sapiens_hsa004800.97243405
72Peroxisome_Homo sapiens_hsa041460.95533516
73beta-Alanine metabolism_Homo sapiens_hsa004100.93716295
74Huntingtons disease_Homo sapiens_hsa050160.92995615
75Protein export_Homo sapiens_hsa030600.92121423
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91808624
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90662614
78Retinol metabolism_Homo sapiens_hsa008300.89253474
79Homologous recombination_Homo sapiens_hsa034400.88716356
80MicroRNAs in cancer_Homo sapiens_hsa052060.88622420
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.88029739
82Asthma_Homo sapiens_hsa053100.85019607
83ABC transporters_Homo sapiens_hsa020100.82662443
84Fanconi anemia pathway_Homo sapiens_hsa034600.82634822
85Nucleotide excision repair_Homo sapiens_hsa034200.82390629
86Spliceosome_Homo sapiens_hsa030400.82011956
87Oxidative phosphorylation_Homo sapiens_hsa001900.81576977
88RNA transport_Homo sapiens_hsa030130.80379410
89Serotonergic synapse_Homo sapiens_hsa047260.78860938
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.77260961
91Vitamin digestion and absorption_Homo sapiens_hsa049770.77252448
92mRNA surveillance pathway_Homo sapiens_hsa030150.76734353
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75807020
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72706389
95Pyrimidine metabolism_Homo sapiens_hsa002400.72587205
96Purine metabolism_Homo sapiens_hsa002300.72570115
97Chronic myeloid leukemia_Homo sapiens_hsa052200.71009129
98Glycerolipid metabolism_Homo sapiens_hsa005610.70673764
99Sulfur metabolism_Homo sapiens_hsa009200.70369538
100mTOR signaling pathway_Homo sapiens_hsa041500.69752257
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69664217
102Bile secretion_Homo sapiens_hsa049760.69169508
103Phenylalanine metabolism_Homo sapiens_hsa003600.67812943
104Viral myocarditis_Homo sapiens_hsa054160.67637614
105Circadian rhythm_Homo sapiens_hsa047100.67630984
106Tight junction_Homo sapiens_hsa045300.66696387
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66001222
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.64431139
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63752365
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60994174
111Proteoglycans in cancer_Homo sapiens_hsa052050.60259866
112Staphylococcus aureus infection_Homo sapiens_hsa051500.59885539
113Thyroid cancer_Homo sapiens_hsa052160.59222976
114Salivary secretion_Homo sapiens_hsa049700.58497109
115ECM-receptor interaction_Homo sapiens_hsa045120.58096173
116Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57229585
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57023068
118Focal adhesion_Homo sapiens_hsa045100.56914921
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56006993
120Pyruvate metabolism_Homo sapiens_hsa006200.53162443
121Prostate cancer_Homo sapiens_hsa052150.52255100
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51635186
123Wnt signaling pathway_Homo sapiens_hsa043100.51338642
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50642925
125Ovarian steroidogenesis_Homo sapiens_hsa049130.50578716
126Parkinsons disease_Homo sapiens_hsa050120.50570066
127Acute myeloid leukemia_Homo sapiens_hsa052210.50260454
128Glutamatergic synapse_Homo sapiens_hsa047240.49533718
129Butanoate metabolism_Homo sapiens_hsa006500.49455479
130Tyrosine metabolism_Homo sapiens_hsa003500.48796846
131Metabolic pathways_Homo sapiens_hsa011000.48235452
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.47531005
133Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47158555
134Carbon metabolism_Homo sapiens_hsa012000.46107615
135AMPK signaling pathway_Homo sapiens_hsa041520.45249439
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45071579
137Shigellosis_Homo sapiens_hsa051310.44270831
138Insulin secretion_Homo sapiens_hsa049110.42846962
139Morphine addiction_Homo sapiens_hsa050320.41996209
140Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39321193
141Circadian entrainment_Homo sapiens_hsa047130.38819574
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38069184
143Cocaine addiction_Homo sapiens_hsa050300.36106210
144Calcium signaling pathway_Homo sapiens_hsa040200.34498369
145Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33683438
146Axon guidance_Homo sapiens_hsa043600.33479661
147Vascular smooth muscle contraction_Homo sapiens_hsa042700.33101235

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