

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit biogenesis (GO:0042274) | 4.94273885 |
| 2 | cullin deneddylation (GO:0010388) | 4.90243988 |
| 3 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.84190131 |
| 4 | maturation of SSU-rRNA (GO:0030490) | 4.82928460 |
| 5 | proteasome assembly (GO:0043248) | 4.80557370 |
| 6 | viral transcription (GO:0019083) | 4.66474697 |
| 7 | translational termination (GO:0006415) | 4.59557701 |
| 8 | protein deneddylation (GO:0000338) | 4.58294348 |
| 9 | ATP synthesis coupled proton transport (GO:0015986) | 4.58105276 |
| 10 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.58105276 |
| 11 | protein neddylation (GO:0045116) | 4.49125169 |
| 12 | termination of RNA polymerase III transcription (GO:0006386) | 4.44991154 |
| 13 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.44991154 |
| 14 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.37582735 |
| 15 | ribosomal large subunit biogenesis (GO:0042273) | 4.28823192 |
| 16 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.25495540 |
| 17 | 7-methylguanosine RNA capping (GO:0009452) | 4.22339540 |
| 18 | RNA capping (GO:0036260) | 4.22339540 |
| 19 | 7-methylguanosine mRNA capping (GO:0006370) | 4.21082788 |
| 20 | ribosomal small subunit assembly (GO:0000028) | 4.19254037 |
| 21 | cotranslational protein targeting to membrane (GO:0006613) | 4.09079878 |
| 22 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.08345324 |
| 23 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.06606184 |
| 24 | negative regulation of ligase activity (GO:0051352) | 4.01399841 |
| 25 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.01399841 |
| 26 | formation of translation preinitiation complex (GO:0001731) | 4.00991486 |
| 27 | chaperone-mediated protein transport (GO:0072321) | 4.00916597 |
| 28 | protein targeting to ER (GO:0045047) | 4.00900530 |
| 29 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.95772776 |
| 30 | translational elongation (GO:0006414) | 3.93727649 |
| 31 | establishment of integrated proviral latency (GO:0075713) | 3.91686047 |
| 32 | translational initiation (GO:0006413) | 3.90480525 |
| 33 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.88005895 |
| 34 | protein localization to endoplasmic reticulum (GO:0070972) | 3.87185426 |
| 35 | * spliceosomal snRNP assembly (GO:0000387) | 3.87171163 |
| 36 | cellular protein complex disassembly (GO:0043624) | 3.84723065 |
| 37 | DNA double-strand break processing (GO:0000729) | 3.84694756 |
| 38 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.82937846 |
| 39 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.80947549 |
| 40 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.78809450 |
| 41 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.76916240 |
| 42 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.76916240 |
| 43 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.73934519 |
| 44 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.73934519 |
| 45 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.73934519 |
| 46 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.70841488 |
| 47 | viral life cycle (GO:0019058) | 3.68163411 |
| 48 | GTP biosynthetic process (GO:0006183) | 3.67741678 |
| 49 | translation (GO:0006412) | 3.67439869 |
| 50 | DNA damage response, detection of DNA damage (GO:0042769) | 3.66707419 |
| 51 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.65446282 |
| 52 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.65364323 |
| 53 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.65364323 |
| 54 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.63548802 |
| 55 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.61813455 |
| 56 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.61779262 |
| 57 | rRNA processing (GO:0006364) | 3.59488344 |
| 58 | respiratory chain complex IV assembly (GO:0008535) | 3.58741318 |
| 59 | rRNA modification (GO:0000154) | 3.58675010 |
| 60 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.56280666 |
| 61 | establishment of viral latency (GO:0019043) | 3.53826287 |
| 62 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.53210931 |
| 63 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.53020882 |
| 64 | CENP-A containing nucleosome assembly (GO:0034080) | 3.52182540 |
| 65 | spliceosomal complex assembly (GO:0000245) | 3.51830358 |
| 66 | maturation of 5.8S rRNA (GO:0000460) | 3.51037073 |
| 67 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.50452020 |
| 68 | pseudouridine synthesis (GO:0001522) | 3.50438483 |
| 69 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.50037391 |
| 70 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.45970010 |
| 71 | rRNA metabolic process (GO:0016072) | 3.44709978 |
| 72 | cellular component biogenesis (GO:0044085) | 3.44286943 |
| 73 | chromatin remodeling at centromere (GO:0031055) | 3.42542301 |
| 74 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.41586808 |
| 75 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.40244280 |
| 76 | positive regulation of ligase activity (GO:0051351) | 3.38388057 |
| 77 | purine nucleobase biosynthetic process (GO:0009113) | 3.36639557 |
| 78 | UTP biosynthetic process (GO:0006228) | 3.35289175 |
| 79 | nucleobase biosynthetic process (GO:0046112) | 3.35087969 |
| 80 | transcription from RNA polymerase I promoter (GO:0006360) | 3.33002053 |
| 81 | DNA strand elongation (GO:0022616) | 3.32996377 |
| 82 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.32835881 |
| 83 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.32835881 |
| 84 | DNA replication checkpoint (GO:0000076) | 3.31991654 |
| 85 | protein complex disassembly (GO:0043241) | 3.31596130 |
| 86 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.31140485 |
| 87 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.31122834 |
| 88 | protein complex biogenesis (GO:0070271) | 3.25720086 |
| 89 | macromolecular complex disassembly (GO:0032984) | 3.25547339 |
| 90 | replication fork processing (GO:0031297) | 3.22980968 |
| 91 | termination of RNA polymerase I transcription (GO:0006363) | 3.22364547 |
| 92 | histone exchange (GO:0043486) | 3.22159491 |
| 93 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.21441177 |
| 94 | establishment of protein localization to mitochondrion (GO:0072655) | 3.20729678 |
| 95 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.16564588 |
| 96 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.16564588 |
| 97 | respiratory electron transport chain (GO:0022904) | 3.15942621 |
| 98 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.15245760 |
| 99 | NADH dehydrogenase complex assembly (GO:0010257) | 3.15245760 |
| 100 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.15245760 |
| 101 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.15233824 |
| 102 | protein targeting to mitochondrion (GO:0006626) | 3.15178854 |
| 103 | ribosome biogenesis (GO:0042254) | 3.15046935 |
| 104 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.13672138 |
| 105 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.11902487 |
| 106 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.11902487 |
| 107 | regulation of mitochondrial translation (GO:0070129) | 3.11106387 |
| 108 | viral mRNA export from host cell nucleus (GO:0046784) | 3.10767679 |
| 109 | cytochrome complex assembly (GO:0017004) | 3.10767357 |
| 110 | regulation of DNA endoreduplication (GO:0032875) | 3.09881990 |
| 111 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.08373958 |
| 112 | protein K6-linked ubiquitination (GO:0085020) | 3.08324019 |
| 113 | protein-cofactor linkage (GO:0018065) | 3.06943227 |
| 114 | electron transport chain (GO:0022900) | 3.06889336 |
| 115 | transcription elongation from RNA polymerase II promoter (GO:0006368) | 3.05775116 |
| 116 | telomere maintenance via recombination (GO:0000722) | 3.05537904 |
| 117 | regulation of ligase activity (GO:0051340) | 3.04439738 |
| 118 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.99273072 |
| 119 | mitotic metaphase plate congression (GO:0007080) | 2.96931258 |
| 120 | behavioral response to nicotine (GO:0035095) | 2.95762873 |
| 121 | regulation of helicase activity (GO:0051095) | 2.86477572 |
| 122 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.80420906 |
| 123 | isotype switching (GO:0045190) | 2.80420906 |
| 124 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.80420906 |
| 125 | mitochondrial RNA metabolic process (GO:0000959) | 2.79185911 |
| 126 | tRNA processing (GO:0008033) | 2.79134547 |
| 127 | metaphase plate congression (GO:0051310) | 2.73879028 |
| 128 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.70758359 |
| 129 | protein localization to kinetochore (GO:0034501) | 2.68702671 |
| 130 | histone mRNA metabolic process (GO:0008334) | 2.68072394 |
| 131 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.66100462 |
| 132 | DNA replication-independent nucleosome organization (GO:0034724) | 2.66100462 |
| 133 | intracellular protein transmembrane import (GO:0044743) | 2.63829569 |
| 134 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.62621548 |
| 135 | protein localization to mitochondrion (GO:0070585) | 2.62330196 |
| 136 | tRNA metabolic process (GO:0006399) | 2.61967265 |
| 137 | rRNA methylation (GO:0031167) | 2.59492369 |
| 138 | telomere maintenance via telomerase (GO:0007004) | 2.58751037 |
| 139 | DNA deamination (GO:0045006) | 2.58352254 |
| 140 | peptidyl-histidine modification (GO:0018202) | 2.57279598 |
| 141 | negative regulation of DNA recombination (GO:0045910) | 2.57163877 |
| 142 | recombinational repair (GO:0000725) | 2.56812888 |
| 143 | centriole replication (GO:0007099) | 2.56684967 |
| 144 | postreplication repair (GO:0006301) | 2.55365978 |
| 145 | double-strand break repair via homologous recombination (GO:0000724) | 2.53967755 |
| 146 | kinetochore organization (GO:0051383) | 2.51883743 |
| 147 | platelet dense granule organization (GO:0060155) | 2.51089858 |
| 148 | kinetochore assembly (GO:0051382) | 2.50116580 |
| 149 | regulation of meiosis I (GO:0060631) | 2.48699900 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.85938868 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.40204087 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.28843818 |
| 4 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.22059900 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.15396592 |
| 6 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.73450227 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.66138852 |
| 8 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.63894272 |
| 9 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.44537499 |
| 10 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.43154389 |
| 11 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.32768459 |
| 12 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.26415522 |
| 13 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.13493553 |
| 14 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.95001261 |
| 15 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.93660026 |
| 16 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.91661698 |
| 17 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.87086287 |
| 18 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.87072959 |
| 19 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.86109143 |
| 20 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.69462205 |
| 21 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.63916783 |
| 22 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.56413832 |
| 23 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.52506490 |
| 24 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.51739264 |
| 25 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.45096453 |
| 26 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.43745358 |
| 27 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.43416675 |
| 28 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.34976027 |
| 29 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.23937158 |
| 30 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.23744630 |
| 31 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.22958069 |
| 32 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.22278115 |
| 33 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.16957672 |
| 34 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.15519239 |
| 35 | VDR_22108803_ChIP-Seq_LS180_Human | 2.12118692 |
| 36 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 2.02665943 |
| 37 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.01807831 |
| 38 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.98459937 |
| 39 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.98213871 |
| 40 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.95399092 |
| 41 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.94431035 |
| 42 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.93197408 |
| 43 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.90218024 |
| 44 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.87302971 |
| 45 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.84420248 |
| 46 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.79886230 |
| 47 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.79063439 |
| 48 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.74521798 |
| 49 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.74401672 |
| 50 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.68837261 |
| 51 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.67510587 |
| 52 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.64989214 |
| 53 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.62836934 |
| 54 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.62800724 |
| 55 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.61556460 |
| 56 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.60304151 |
| 57 | P300_19829295_ChIP-Seq_ESCs_Human | 1.57361681 |
| 58 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.51784347 |
| 59 | * MYC_18940864_ChIP-ChIP_HL60_Human | 1.50524712 |
| 60 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.50273253 |
| 61 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.49996969 |
| 62 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.47879200 |
| 63 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.46766731 |
| 64 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.45814291 |
| 65 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.43249413 |
| 66 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.41856383 |
| 67 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.40950957 |
| 68 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.40239445 |
| 69 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.36326306 |
| 70 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.35334174 |
| 71 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.34901388 |
| 72 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.34158786 |
| 73 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.34076987 |
| 74 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.32467983 |
| 75 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.32058112 |
| 76 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.31957946 |
| 77 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.31336380 |
| 78 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.27257455 |
| 79 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.26326313 |
| 80 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.24296896 |
| 81 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.18501045 |
| 82 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.16543708 |
| 83 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.16019798 |
| 84 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.15564095 |
| 85 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.14147559 |
| 86 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.14035553 |
| 87 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.13112324 |
| 88 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.12650110 |
| 89 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.08844643 |
| 90 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.08648695 |
| 91 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.08617349 |
| 92 | FUS_26573619_Chip-Seq_HEK293_Human | 1.08450377 |
| 93 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.07348936 |
| 94 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.04320429 |
| 95 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.03190818 |
| 96 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.02949427 |
| 97 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.02722756 |
| 98 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.00781923 |
| 99 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.99190816 |
| 100 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.98584426 |
| 101 | EZH2_22144423_ChIP-Seq_EOC_Human | 0.98177545 |
| 102 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.97061938 |
| 103 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.96682714 |
| 104 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.96263122 |
| 105 | * SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.95727155 |
| 106 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.95708051 |
| 107 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.94770164 |
| 108 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.94770164 |
| 109 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.94383296 |
| 110 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.94310428 |
| 111 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.93958565 |
| 112 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.92595568 |
| 113 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.91738898 |
| 114 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.91738898 |
| 115 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.91027648 |
| 116 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.90419319 |
| 117 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.90023514 |
| 118 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.90000140 |
| 119 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 0.88425834 |
| 120 | EWS_26573619_Chip-Seq_HEK293_Human | 0.87833533 |
| 121 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.87640983 |
| 122 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 0.85792766 |
| 123 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.85646667 |
| 124 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.85555943 |
| 125 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.84735499 |
| 126 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.84388174 |
| 127 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.83622306 |
| 128 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.76636717 |
| 129 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.76020601 |
| 130 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.74241379 |
| 131 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.73938950 |
| 132 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.73273373 |
| 133 | REST_19997604_ChIP-ChIP_NEURONS_Mouse | 0.71860589 |
| 134 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.68700688 |
| 135 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.66526066 |
| 136 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.65283921 |
| 137 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.63984456 |
| 138 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.63265373 |
| 139 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.62753294 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0006292_abnormal_olfactory_placode | 4.01949629 |
| 2 | MP0003123_paternal_imprinting | 3.65610212 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 3.06581519 |
| 4 | MP0009379_abnormal_foot_pigmentation | 2.96620753 |
| 5 | MP0003880_abnormal_central_pattern | 2.96288372 |
| 6 | MP0001529_abnormal_vocalization | 2.89708584 |
| 7 | MP0003693_abnormal_embryo_hatching | 2.81269010 |
| 8 | MP0008057_abnormal_DNA_replication | 2.76737078 |
| 9 | MP0010094_abnormal_chromosome_stability | 2.49710732 |
| 10 | MP0008058_abnormal_DNA_repair | 2.44400368 |
| 11 | MP0008932_abnormal_embryonic_tissue | 2.44088357 |
| 12 | MP0003077_abnormal_cell_cycle | 2.28529611 |
| 13 | MP0009697_abnormal_copulation | 2.26125005 |
| 14 | MP0003121_genomic_imprinting | 2.23534728 |
| 15 | MP0003718_maternal_effect | 2.21809224 |
| 16 | MP0003890_abnormal_embryonic-extraembry | 2.14088364 |
| 17 | MP0002638_abnormal_pupillary_reflex | 2.11785767 |
| 18 | MP0001905_abnormal_dopamine_level | 2.04092101 |
| 19 | MP0010030_abnormal_orbit_morphology | 1.98716525 |
| 20 | MP0003111_abnormal_nucleus_morphology | 1.95427851 |
| 21 | MP0006276_abnormal_autonomic_nervous | 1.91229679 |
| 22 | MP0003122_maternal_imprinting | 1.90153750 |
| 23 | MP0002163_abnormal_gland_morphology | 1.87214367 |
| 24 | MP0003315_abnormal_perineum_morphology | 1.85101512 |
| 25 | MP0002751_abnormal_autonomic_nervous | 1.77880408 |
| 26 | MP0003136_yellow_coat_color | 1.77458173 |
| 27 | MP0008877_abnormal_DNA_methylation | 1.74317422 |
| 28 | MP0001188_hyperpigmentation | 1.66353150 |
| 29 | MP0003786_premature_aging | 1.65528671 |
| 30 | MP0005423_abnormal_somatic_nervous | 1.65320723 |
| 31 | MP0006072_abnormal_retinal_apoptosis | 1.64230617 |
| 32 | MP0008007_abnormal_cellular_replicative | 1.59312981 |
| 33 | MP0009046_muscle_twitch | 1.53374872 |
| 34 | MP0004133_heterotaxia | 1.51763778 |
| 35 | MP0003806_abnormal_nucleotide_metabolis | 1.47852180 |
| 36 | MP0003941_abnormal_skin_development | 1.46558635 |
| 37 | MP0001986_abnormal_taste_sensitivity | 1.42084680 |
| 38 | MP0000569_abnormal_digit_pigmentation | 1.41867566 |
| 39 | MP0003195_calcinosis | 1.39857975 |
| 40 | MP0008789_abnormal_olfactory_epithelium | 1.38948313 |
| 41 | MP0000778_abnormal_nervous_system | 1.38312856 |
| 42 | MP0002938_white_spotting | 1.37377070 |
| 43 | MP0002160_abnormal_reproductive_system | 1.33483566 |
| 44 | MP0004215_abnormal_myocardial_fiber | 1.33201208 |
| 45 | MP0000566_synostosis | 1.31621644 |
| 46 | MP0000631_abnormal_neuroendocrine_gland | 1.28488305 |
| 47 | MP0005408_hypopigmentation | 1.27700459 |
| 48 | MP0001346_abnormal_lacrimal_gland | 1.25769461 |
| 49 | MP0000427_abnormal_hair_cycle | 1.25156517 |
| 50 | MP0002102_abnormal_ear_morphology | 1.24031196 |
| 51 | MP0003186_abnormal_redox_activity | 1.23541116 |
| 52 | MP0001984_abnormal_olfaction | 1.21823021 |
| 53 | MP0002734_abnormal_mechanical_nocicepti | 1.21490717 |
| 54 | MP0003011_delayed_dark_adaptation | 1.18731439 |
| 55 | MP0000647_abnormal_sebaceous_gland | 1.17320813 |
| 56 | MP0001730_embryonic_growth_arrest | 1.15268153 |
| 57 | MP0005389_reproductive_system_phenotype | 1.12905194 |
| 58 | MP0002837_dystrophic_cardiac_calcinosis | 1.11505588 |
| 59 | MP0008872_abnormal_physiological_respon | 1.11263776 |
| 60 | MP0002234_abnormal_pharynx_morphology | 1.11117346 |
| 61 | MP0005645_abnormal_hypothalamus_physiol | 1.10851825 |
| 62 | MP0005084_abnormal_gallbladder_morpholo | 1.10396668 |
| 63 | MP0010386_abnormal_urinary_bladder | 1.10240997 |
| 64 | MP0002282_abnormal_trachea_morphology | 1.05639054 |
| 65 | MP0005551_abnormal_eye_electrophysiolog | 1.04613086 |
| 66 | MP0004381_abnormal_hair_follicle | 1.03544879 |
| 67 | MP0002736_abnormal_nociception_after | 1.03096663 |
| 68 | MP0001486_abnormal_startle_reflex | 1.02811084 |
| 69 | MP0004147_increased_porphyrin_level | 0.98929170 |
| 70 | MP0001968_abnormal_touch/_nociception | 0.98088086 |
| 71 | MP0005187_abnormal_penis_morphology | 0.97594752 |
| 72 | MP0008875_abnormal_xenobiotic_pharmacok | 0.97117834 |
| 73 | MP0000049_abnormal_middle_ear | 0.97049754 |
| 74 | MP0000372_irregular_coat_pigmentation | 0.97034716 |
| 75 | MP0001929_abnormal_gametogenesis | 0.96490297 |
| 76 | MP0004142_abnormal_muscle_tone | 0.96469424 |
| 77 | MP0000350_abnormal_cell_proliferation | 0.96424615 |
| 78 | MP0004270_analgesia | 0.95841125 |
| 79 | MP0002210_abnormal_sex_determination | 0.95550985 |
| 80 | MP0003119_abnormal_digestive_system | 0.94761611 |
| 81 | MP0003938_abnormal_ear_development | 0.94611607 |
| 82 | MP0002184_abnormal_innervation | 0.94495822 |
| 83 | MP0005174_abnormal_tail_pigmentation | 0.94079710 |
| 84 | MP0005394_taste/olfaction_phenotype | 0.93822758 |
| 85 | MP0005499_abnormal_olfactory_system | 0.93822758 |
| 86 | MP0005379_endocrine/exocrine_gland_phen | 0.91985203 |
| 87 | MP0001697_abnormal_embryo_size | 0.91876513 |
| 88 | MP0003937_abnormal_limbs/digits/tail_de | 0.90634683 |
| 89 | MP0005253_abnormal_eye_physiology | 0.90063147 |
| 90 | MP0002233_abnormal_nose_morphology | 0.90022401 |
| 91 | MP0001286_abnormal_eye_development | 0.89836829 |
| 92 | MP0008260_abnormal_autophagy | 0.88592881 |
| 93 | MP0002735_abnormal_chemical_nociception | 0.87087721 |
| 94 | MP0003755_abnormal_palate_morphology | 0.86168208 |
| 95 | MP0001919_abnormal_reproductive_system | 0.85565126 |
| 96 | MP0002095_abnormal_skin_pigmentation | 0.85531952 |
| 97 | MP0002752_abnormal_somatic_nervous | 0.85231281 |
| 98 | MP0001485_abnormal_pinna_reflex | 0.84898917 |
| 99 | MP0008995_early_reproductive_senescence | 0.84842431 |
| 100 | MP0003646_muscle_fatigue | 0.84135399 |
| 101 | MP0002277_abnormal_respiratory_mucosa | 0.83983783 |
| 102 | MP0005377_hearing/vestibular/ear_phenot | 0.83584762 |
| 103 | MP0003878_abnormal_ear_physiology | 0.83584762 |
| 104 | MP0003137_abnormal_impulse_conducting | 0.83006593 |
| 105 | MP0002572_abnormal_emotion/affect_behav | 0.82125913 |
| 106 | MP0002272_abnormal_nervous_system | 0.82083986 |
| 107 | MP0005195_abnormal_posterior_eye | 0.82027681 |
| 108 | MP0000026_abnormal_inner_ear | 0.81752903 |
| 109 | MP0006035_abnormal_mitochondrial_morpho | 0.81265968 |
| 110 | MP0001299_abnormal_eye_distance/ | 0.81243356 |
| 111 | MP0001727_abnormal_embryo_implantation | 0.80542321 |
| 112 | MP0005075_abnormal_melanosome_morpholog | 0.80197128 |
| 113 | MP0002064_seizures | 0.80125660 |
| 114 | MP0001145_abnormal_male_reproductive | 0.79841261 |
| 115 | MP0003861_abnormal_nervous_system | 0.79655573 |
| 116 | MP0002653_abnormal_ependyma_morphology | 0.79650646 |
| 117 | MP0001293_anophthalmia | 0.77641800 |
| 118 | MP0002085_abnormal_embryonic_tissue | 0.74720888 |
| 119 | MP0009250_abnormal_appendicular_skeleto | 0.73802154 |
| 120 | MP0009745_abnormal_behavioral_response | 0.72901811 |
| 121 | MP0001672_abnormal_embryogenesis/_devel | 0.72531053 |
| 122 | MP0005380_embryogenesis_phenotype | 0.72531053 |
| 123 | MP0003567_abnormal_fetal_cardiomyocyte | 0.72032130 |
| 124 | MP0000537_abnormal_urethra_morphology | 0.71172134 |
| 125 | MP0003787_abnormal_imprinting | 0.71115845 |
| 126 | MP0006036_abnormal_mitochondrial_physio | 0.70505159 |
| 127 | MP0000653_abnormal_sex_gland | 0.70388837 |
| 128 | MP0001970_abnormal_pain_threshold | 0.69057964 |
| 129 | MP0002080_prenatal_lethality | 0.68685508 |
| 130 | MP0005409_darkened_coat_color | 0.68353188 |
| 131 | MP0002882_abnormal_neuron_morphology | 0.67930802 |
| 132 | MP0002067_abnormal_sensory_capabilities | 0.67741841 |
| 133 | MP0005171_absent_coat_pigmentation | 0.67391732 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.01448825 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.33108221 |
| 3 | Mitochondrial inheritance (HP:0001427) | 4.29036826 |
| 4 | Progressive macrocephaly (HP:0004481) | 4.08680091 |
| 5 | Increased serum pyruvate (HP:0003542) | 3.93300912 |
| 6 | Abnormality of glycolysis (HP:0004366) | 3.93300912 |
| 7 | Birth length less than 3rd percentile (HP:0003561) | 3.91778387 |
| 8 | Acute encephalopathy (HP:0006846) | 3.75856294 |
| 9 | Increased CSF lactate (HP:0002490) | 3.69339812 |
| 10 | Breast hypoplasia (HP:0003187) | 3.63615989 |
| 11 | Cerebral hypomyelination (HP:0006808) | 3.62552938 |
| 12 | Hepatocellular necrosis (HP:0001404) | 3.55368441 |
| 13 | Increased hepatocellular lipid droplets (HP:0006565) | 3.42096052 |
| 14 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.27353903 |
| 15 | Macrocytic anemia (HP:0001972) | 3.26099377 |
| 16 | Molar tooth sign on MRI (HP:0002419) | 3.08624801 |
| 17 | Abnormality of midbrain morphology (HP:0002418) | 3.08624801 |
| 18 | Reticulocytopenia (HP:0001896) | 3.03832196 |
| 19 | 3-Methylglutaconic aciduria (HP:0003535) | 3.03006617 |
| 20 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.95357474 |
| 21 | Abnormality of the labia minora (HP:0012880) | 2.94791092 |
| 22 | Renal Fanconi syndrome (HP:0001994) | 2.94360870 |
| 23 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.93585839 |
| 24 | Methylmalonic acidemia (HP:0002912) | 2.88805078 |
| 25 | Optic disc pallor (HP:0000543) | 2.88195043 |
| 26 | Hepatic necrosis (HP:0002605) | 2.83912033 |
| 27 | Colon cancer (HP:0003003) | 2.80330069 |
| 28 | Abnormal number of erythroid precursors (HP:0012131) | 2.78127784 |
| 29 | Leukodystrophy (HP:0002415) | 2.77537315 |
| 30 | Lipid accumulation in hepatocytes (HP:0006561) | 2.73001141 |
| 31 | Increased serum lactate (HP:0002151) | 2.71236849 |
| 32 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.60871496 |
| 33 | Abnormality of alanine metabolism (HP:0010916) | 2.60871496 |
| 34 | Hyperalaninemia (HP:0003348) | 2.60871496 |
| 35 | Congenital, generalized hypertrichosis (HP:0004540) | 2.53329052 |
| 36 | Medial flaring of the eyebrow (HP:0010747) | 2.53112932 |
| 37 | Exercise intolerance (HP:0003546) | 2.43442810 |
| 38 | Nephronophthisis (HP:0000090) | 2.43064978 |
| 39 | Gait imbalance (HP:0002141) | 2.40432537 |
| 40 | Pallor (HP:0000980) | 2.39924592 |
| 41 | Congenital primary aphakia (HP:0007707) | 2.36284535 |
| 42 | Respiratory failure (HP:0002878) | 2.36251590 |
| 43 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.34644902 |
| 44 | Pancreatic cysts (HP:0001737) | 2.32122217 |
| 45 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.31747020 |
| 46 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.31747020 |
| 47 | Methylmalonic aciduria (HP:0012120) | 2.31457636 |
| 48 | Patellar aplasia (HP:0006443) | 2.31139518 |
| 49 | Pancreatic fibrosis (HP:0100732) | 2.30327478 |
| 50 | Nephrogenic diabetes insipidus (HP:0009806) | 2.26913306 |
| 51 | Meckel diverticulum (HP:0002245) | 2.26518784 |
| 52 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.24634129 |
| 53 | Postnatal microcephaly (HP:0005484) | 2.24588747 |
| 54 | Progressive inability to walk (HP:0002505) | 2.22029712 |
| 55 | CNS hypomyelination (HP:0003429) | 2.21700412 |
| 56 | True hermaphroditism (HP:0010459) | 2.21206451 |
| 57 | Supernumerary spleens (HP:0009799) | 2.20931811 |
| 58 | Triphalangeal thumb (HP:0001199) | 2.20078298 |
| 59 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.20044536 |
| 60 | Cerebral edema (HP:0002181) | 2.19037263 |
| 61 | Abnormality of the ileum (HP:0001549) | 2.18716278 |
| 62 | Abnormality of the preputium (HP:0100587) | 2.16125502 |
| 63 | Septo-optic dysplasia (HP:0100842) | 2.15498925 |
| 64 | Oral leukoplakia (HP:0002745) | 2.15028051 |
| 65 | Abnormality of the hip-girdle musculature (HP:0001445) | 2.13916883 |
| 66 | Abnormality of the musculature of the pelvis (HP:0001469) | 2.13916883 |
| 67 | Volvulus (HP:0002580) | 2.13048298 |
| 68 | Abnormal lung lobation (HP:0002101) | 2.12939130 |
| 69 | Respiratory difficulties (HP:0002880) | 2.12192383 |
| 70 | Congenital stationary night blindness (HP:0007642) | 2.11964356 |
| 71 | Ependymoma (HP:0002888) | 2.08174549 |
| 72 | Aplastic anemia (HP:0001915) | 2.07370234 |
| 73 | Inability to walk (HP:0002540) | 2.06775263 |
| 74 | Lactic acidosis (HP:0003128) | 2.06415261 |
| 75 | Sclerocornea (HP:0000647) | 2.05948451 |
| 76 | Absent radius (HP:0003974) | 2.03922913 |
| 77 | Exertional dyspnea (HP:0002875) | 2.02639951 |
| 78 | Abnormality of serum amino acid levels (HP:0003112) | 2.02445846 |
| 79 | Carpal bone hypoplasia (HP:0001498) | 1.99730425 |
| 80 | Hypoplasia of the pons (HP:0012110) | 1.99694075 |
| 81 | Renal cortical cysts (HP:0000803) | 1.98771705 |
| 82 | Abnormality of the renal cortex (HP:0011035) | 1.98206925 |
| 83 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.97518289 |
| 84 | Progressive external ophthalmoplegia (HP:0000590) | 1.97476258 |
| 85 | Hyperventilation (HP:0002883) | 1.97265344 |
| 86 | Abnormality of the pons (HP:0007361) | 1.96676025 |
| 87 | Rough bone trabeculation (HP:0100670) | 1.96430605 |
| 88 | Horseshoe kidney (HP:0000085) | 1.95541048 |
| 89 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.93501549 |
| 90 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.93254834 |
| 91 | Irregular epiphyses (HP:0010582) | 1.92859183 |
| 92 | Lissencephaly (HP:0001339) | 1.92370388 |
| 93 | Abnormality of the septum pellucidum (HP:0007375) | 1.91927515 |
| 94 | Vaginal atresia (HP:0000148) | 1.91637132 |
| 95 | Absent forearm bone (HP:0003953) | 1.91240965 |
| 96 | Aplasia involving forearm bones (HP:0009822) | 1.91240965 |
| 97 | Abnormality of the renal medulla (HP:0100957) | 1.90837266 |
| 98 | Pendular nystagmus (HP:0012043) | 1.90505904 |
| 99 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.90206947 |
| 100 | Type II lissencephaly (HP:0007260) | 1.89840038 |
| 101 | Chromsome breakage (HP:0040012) | 1.89518605 |
| 102 | Glioma (HP:0009733) | 1.88675207 |
| 103 | Small hand (HP:0200055) | 1.86602611 |
| 104 | Genital tract atresia (HP:0001827) | 1.86141864 |
| 105 | Abnormality of methionine metabolism (HP:0010901) | 1.86136614 |
| 106 | Stenosis of the external auditory canal (HP:0000402) | 1.85201135 |
| 107 | Hyperglycinemia (HP:0002154) | 1.84255079 |
| 108 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.83979025 |
| 109 | Emotional lability (HP:0000712) | 1.83506682 |
| 110 | Abnormal number of incisors (HP:0011064) | 1.82796628 |
| 111 | Short tibia (HP:0005736) | 1.81734689 |
| 112 | Lethargy (HP:0001254) | 1.81182449 |
| 113 | Adrenal hypoplasia (HP:0000835) | 1.81162619 |
| 114 | Bilateral microphthalmos (HP:0007633) | 1.81159485 |
| 115 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.79399396 |
| 116 | Male pseudohermaphroditism (HP:0000037) | 1.78077386 |
| 117 | Facial cleft (HP:0002006) | 1.77518014 |
| 118 | Microvesicular hepatic steatosis (HP:0001414) | 1.77068455 |
| 119 | Optic nerve hypoplasia (HP:0000609) | 1.76717535 |
| 120 | Hypothermia (HP:0002045) | 1.76459688 |
| 121 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.74619559 |
| 122 | Glossoptosis (HP:0000162) | 1.74135938 |
| 123 | Delusions (HP:0000746) | 1.73606122 |
| 124 | Increased intramyocellular lipid droplets (HP:0012240) | 1.73413276 |
| 125 | Cleft eyelid (HP:0000625) | 1.71897966 |
| 126 | Sloping forehead (HP:0000340) | 1.71243382 |
| 127 | Secondary amenorrhea (HP:0000869) | 1.70372234 |
| 128 | Poor coordination (HP:0002370) | 1.69421833 |
| 129 | Unsteady gait (HP:0002317) | 1.69159825 |
| 130 | Small intestinal stenosis (HP:0012848) | 1.68737711 |
| 131 | Duodenal stenosis (HP:0100867) | 1.68737711 |
| 132 | Premature graying of hair (HP:0002216) | 1.68255495 |
| 133 | Absent septum pellucidum (HP:0001331) | 1.67846436 |
| 134 | Abnormality of chromosome stability (HP:0003220) | 1.67071330 |
| 135 | Abnormal protein glycosylation (HP:0012346) | 1.66232353 |
| 136 | Abnormal glycosylation (HP:0012345) | 1.66232353 |
| 137 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.66232353 |
| 138 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.66232353 |
| 139 | Anencephaly (HP:0002323) | 1.65751804 |
| 140 | Abnormality of renal resorption (HP:0011038) | 1.65639406 |
| 141 | CNS demyelination (HP:0007305) | 1.65634485 |
| 142 | Asplenia (HP:0001746) | 1.65602946 |
| 143 | Nasolacrimal duct obstruction (HP:0000579) | 1.61996271 |
| 144 | Preaxial hand polydactyly (HP:0001177) | 1.61072032 |
| 145 | Type I transferrin isoform profile (HP:0003642) | 1.60893727 |
| 146 | Neuroendocrine neoplasm (HP:0100634) | 1.60205082 |
| 147 | Poor suck (HP:0002033) | 1.59275096 |
| 148 | X-linked dominant inheritance (HP:0001423) | 1.57609125 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.54699144 |
| 2 | STK16 | 3.89766576 |
| 3 | TLK1 | 3.22516181 |
| 4 | SRPK1 | 2.87053426 |
| 5 | WEE1 | 2.52233060 |
| 6 | NME2 | 2.47620498 |
| 7 | TSSK6 | 2.45214866 |
| 8 | MST4 | 2.42970550 |
| 9 | CASK | 2.42021492 |
| 10 | FRK | 2.39794755 |
| 11 | NUAK1 | 2.37349129 |
| 12 | EIF2AK1 | 2.34359143 |
| 13 | MKNK1 | 2.34152860 |
| 14 | TRIM28 | 2.33397125 |
| 15 | NME1 | 2.32159535 |
| 16 | MAP4K2 | 2.27868159 |
| 17 | VRK2 | 2.26411523 |
| 18 | PBK | 2.23115641 |
| 19 | CDC7 | 2.08758427 |
| 20 | TNIK | 1.95976984 |
| 21 | MKNK2 | 1.92205187 |
| 22 | PNCK | 1.91717092 |
| 23 | EIF2AK3 | 1.88957204 |
| 24 | VRK1 | 1.88119427 |
| 25 | BRSK2 | 1.80552484 |
| 26 | PLK4 | 1.76871556 |
| 27 | TESK2 | 1.63211617 |
| 28 | DYRK2 | 1.62566951 |
| 29 | MAP3K12 | 1.58267112 |
| 30 | PLK3 | 1.51830350 |
| 31 | BMPR1B | 1.50971260 |
| 32 | CDK8 | 1.39558921 |
| 33 | BCR | 1.39115426 |
| 34 | LIMK1 | 1.35215861 |
| 35 | ACVR1B | 1.20971565 |
| 36 | PLK1 | 1.20389144 |
| 37 | PDK2 | 1.18536881 |
| 38 | CDK7 | 1.18080420 |
| 39 | PLK2 | 1.17443147 |
| 40 | TAF1 | 1.17411980 |
| 41 | MAP3K4 | 1.16262389 |
| 42 | AURKA | 1.15456173 |
| 43 | BRAF | 1.09891305 |
| 44 | INSRR | 1.08939282 |
| 45 | CSNK1G3 | 1.04676303 |
| 46 | DYRK3 | 1.01999254 |
| 47 | ERBB3 | 1.00960057 |
| 48 | CDK19 | 1.00621807 |
| 49 | BRSK1 | 0.97978028 |
| 50 | MARK1 | 0.97478290 |
| 51 | PASK | 0.95280282 |
| 52 | ARAF | 0.92647573 |
| 53 | PAK3 | 0.90126371 |
| 54 | AKT3 | 0.88088356 |
| 55 | NEK1 | 0.87459746 |
| 56 | AURKB | 0.84250509 |
| 57 | OXSR1 | 0.83455977 |
| 58 | STK39 | 0.80837754 |
| 59 | TGFBR1 | 0.80419946 |
| 60 | ATR | 0.80067143 |
| 61 | WNK4 | 0.79923394 |
| 62 | MAPK13 | 0.77314610 |
| 63 | PHKG2 | 0.76762875 |
| 64 | PHKG1 | 0.76762875 |
| 65 | UHMK1 | 0.75638855 |
| 66 | CSNK2A2 | 0.74796407 |
| 67 | MAP2K7 | 0.73790335 |
| 68 | PRKCE | 0.72462318 |
| 69 | CSNK2A1 | 0.72352902 |
| 70 | ERBB4 | 0.70012076 |
| 71 | RPS6KA5 | 0.69837634 |
| 72 | GRK5 | 0.67593344 |
| 73 | CSNK1G1 | 0.66103528 |
| 74 | EPHA4 | 0.65426704 |
| 75 | CHEK2 | 0.64856289 |
| 76 | ATM | 0.64573260 |
| 77 | STK3 | 0.63970551 |
| 78 | TTK | 0.63458431 |
| 79 | CAMK2B | 0.62794413 |
| 80 | TIE1 | 0.62181888 |
| 81 | MYLK | 0.60977117 |
| 82 | ILK | 0.60389483 |
| 83 | PINK1 | 0.60123807 |
| 84 | TXK | 0.59874286 |
| 85 | CDK14 | 0.58827911 |
| 86 | CCNB1 | 0.58683520 |
| 87 | YES1 | 0.58542658 |
| 88 | BMPR2 | 0.56061737 |
| 89 | WNK3 | 0.55655009 |
| 90 | STK38L | 0.55034341 |
| 91 | PAK1 | 0.54029782 |
| 92 | PIM2 | 0.53745281 |
| 93 | ZAK | 0.52342870 |
| 94 | BCKDK | 0.52018586 |
| 95 | CSNK1A1L | 0.51576288 |
| 96 | RPS6KA4 | 0.51288328 |
| 97 | PAK4 | 0.50071706 |
| 98 | CDK18 | 0.48753107 |
| 99 | EIF2AK2 | 0.48219308 |
| 100 | ROCK2 | 0.48158353 |
| 101 | CHEK1 | 0.47641873 |
| 102 | CAMKK2 | 0.47495745 |
| 103 | TESK1 | 0.46853720 |
| 104 | DAPK3 | 0.45878876 |
| 105 | DYRK1A | 0.44337537 |
| 106 | CDK15 | 0.43753041 |
| 107 | CDK11A | 0.42935684 |
| 108 | MINK1 | 0.42720658 |
| 109 | CAMK2A | 0.42169496 |
| 110 | MUSK | 0.42123907 |
| 111 | CSNK1G2 | 0.42004706 |
| 112 | GRK7 | 0.41861716 |
| 113 | NEK2 | 0.41356010 |
| 114 | CSNK1E | 0.40929030 |
| 115 | ADRBK1 | 0.40750300 |
| 116 | PRKCI | 0.40454843 |
| 117 | PRPF4B | 0.39276895 |
| 118 | CSNK1A1 | 0.39125668 |
| 119 | CDK1 | 0.38675284 |
| 120 | ADRBK2 | 0.37785038 |
| 121 | CLK1 | 0.36909302 |
| 122 | DAPK1 | 0.36904437 |
| 123 | NEK6 | 0.36323782 |
| 124 | PRKDC | 0.35928684 |
| 125 | PRKCG | 0.35769695 |
| 126 | MAPKAPK5 | 0.33392320 |
| 127 | EPHA2 | 0.32828751 |
| 128 | CDK2 | 0.32589772 |
| 129 | CDK3 | 0.32034085 |
| 130 | ALK | 0.31920432 |
| 131 | CSNK1D | 0.31075952 |
| 132 | LATS1 | 0.30793019 |
| 133 | GRK1 | 0.30163509 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.81338776 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 4.75078447 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 4.24148321 |
| 4 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.52811303 |
| 5 | DNA replication_Homo sapiens_hsa03030 | 3.22563032 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.08788322 |
| 7 | Parkinsons disease_Homo sapiens_hsa05012 | 3.05756736 |
| 8 | Spliceosome_Homo sapiens_hsa03040 | 2.99930622 |
| 9 | Mismatch repair_Homo sapiens_hsa03430 | 2.99323054 |
| 10 | Protein export_Homo sapiens_hsa03060 | 2.49614236 |
| 11 | Huntingtons disease_Homo sapiens_hsa05016 | 2.45758086 |
| 12 | * RNA transport_Homo sapiens_hsa03013 | 2.43041312 |
| 13 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.36979325 |
| 14 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.35835319 |
| 15 | Homologous recombination_Homo sapiens_hsa03440 | 2.27747297 |
| 16 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.14358392 |
| 17 | Alzheimers disease_Homo sapiens_hsa05010 | 2.12973474 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 2.07835602 |
| 19 | Base excision repair_Homo sapiens_hsa03410 | 1.94789695 |
| 20 | RNA degradation_Homo sapiens_hsa03018 | 1.80780152 |
| 21 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.68754260 |
| 22 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.68265946 |
| 23 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.67290256 |
| 24 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.66890609 |
| 25 | Cell cycle_Homo sapiens_hsa04110 | 1.66003732 |
| 26 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.62700629 |
| 27 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.52769819 |
| 28 | Purine metabolism_Homo sapiens_hsa00230 | 1.49308584 |
| 29 | Phototransduction_Homo sapiens_hsa04744 | 1.41713785 |
| 30 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.36352740 |
| 31 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.28081893 |
| 32 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.25864442 |
| 33 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.23676598 |
| 34 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.22065965 |
| 35 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.12878478 |
| 36 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.10812766 |
| 37 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.04746663 |
| 38 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.01597628 |
| 39 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.00917592 |
| 40 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.96435159 |
| 41 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.95905982 |
| 42 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.91231354 |
| 43 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.86480768 |
| 44 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.85785121 |
| 45 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.83014037 |
| 46 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.82465594 |
| 47 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.80135947 |
| 48 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.79123308 |
| 49 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.77065386 |
| 50 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.75874021 |
| 51 | Peroxisome_Homo sapiens_hsa04146 | 0.75378982 |
| 52 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.74860272 |
| 53 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.74552969 |
| 54 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.72727005 |
| 55 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.72368390 |
| 56 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.72135935 |
| 57 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.70686332 |
| 58 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.68875591 |
| 59 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.66997168 |
| 60 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.65277598 |
| 61 | Nicotine addiction_Homo sapiens_hsa05033 | 0.64474669 |
| 62 | Alcoholism_Homo sapiens_hsa05034 | 0.61372386 |
| 63 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.60736545 |
| 64 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.60722658 |
| 65 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.60574671 |
| 66 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.57489000 |
| 67 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.55918032 |
| 68 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.52423410 |
| 69 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.51965764 |
| 70 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.51797687 |
| 71 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.50414965 |
| 72 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.49552843 |
| 73 | Metabolic pathways_Homo sapiens_hsa01100 | 0.48351285 |
| 74 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.47266955 |
| 75 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.46668378 |
| 76 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.45917084 |
| 77 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.45085108 |
| 78 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.45049057 |
| 79 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.43625189 |
| 80 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.43349386 |
| 81 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.42494556 |
| 82 | Retinol metabolism_Homo sapiens_hsa00830 | 0.41673059 |
| 83 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.41249528 |
| 84 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.40983622 |
| 85 | Olfactory transduction_Homo sapiens_hsa04740 | 0.40816796 |
| 86 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.38647630 |
| 87 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.38628901 |
| 88 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.35798293 |
| 89 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.35229964 |
| 90 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.34681652 |
| 91 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.34229465 |
| 92 | Phagosome_Homo sapiens_hsa04145 | 0.33713133 |
| 93 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.33295029 |
| 94 | Circadian rhythm_Homo sapiens_hsa04710 | 0.30682088 |
| 95 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.30287789 |
| 96 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.29122106 |
| 97 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.24887033 |
| 98 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.24844534 |
| 99 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.24066146 |
| 100 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.23162828 |
| 101 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.23068119 |
| 102 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.21366573 |
| 103 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.19807166 |
| 104 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.19158691 |
| 105 | Allograft rejection_Homo sapiens_hsa05330 | 0.18661208 |
| 106 | Asthma_Homo sapiens_hsa05310 | 0.18404530 |
| 107 | Axon guidance_Homo sapiens_hsa04360 | 0.17975525 |
| 108 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.17134170 |
| 109 | GABAergic synapse_Homo sapiens_hsa04727 | 0.16496782 |
| 110 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.16410279 |
| 111 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.16048717 |
| 112 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.15820801 |
| 113 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.15653120 |
| 114 | Taste transduction_Homo sapiens_hsa04742 | 0.14776262 |
| 115 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.13454140 |
| 116 | HTLV-I infection_Homo sapiens_hsa05166 | 0.12562290 |
| 117 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.09964865 |
| 118 | Morphine addiction_Homo sapiens_hsa05032 | 0.08331095 |
| 119 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.08120933 |
| 120 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.07174264 |
| 121 | Thyroid cancer_Homo sapiens_hsa05216 | 0.06434686 |
| 122 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.06159956 |
| 123 | Long-term depression_Homo sapiens_hsa04730 | 0.05825252 |
| 124 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.05092039 |
| 125 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.04989059 |
| 126 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.04934143 |
| 127 | Viral myocarditis_Homo sapiens_hsa05416 | 0.04321799 |
| 128 | Sulfur relay system_Homo sapiens_hsa04122 | 0.03951902 |
| 129 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.03602370 |
| 130 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.03436379 |
| 131 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.03171891 |
| 132 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.02708435 |
| 133 | Melanoma_Homo sapiens_hsa05218 | 0.02221953 |

