PHB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)7.42932934
2maintenance of protein location in nucleus (GO:0051457)6.91465523
3negative regulation of epidermis development (GO:0045683)6.63799216
4somite rostral/caudal axis specification (GO:0032525)6.53289283
5regulation of response to osmotic stress (GO:0047484)6.42798902
6negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.37043148
7protein localization to kinetochore (GO:0034501)6.27605071
8muscle organ morphogenesis (GO:0048644)5.88316873
9regulation of nuclear cell cycle DNA replication (GO:0033262)5.88007281
10regulation of telomere maintenance via telomerase (GO:0032210)5.80452320
11negative regulation of cell cycle G2/M phase transition (GO:1902750)5.77303901
12negative regulation of telomerase activity (GO:0051974)5.76126122
13histone H4-K5 acetylation (GO:0043981)5.58652123
14histone H4-K8 acetylation (GO:0043982)5.58652123
15rRNA transcription (GO:0009303)5.54347024
16regulation of MHC class I biosynthetic process (GO:0045343)5.49526437
17DNA unwinding involved in DNA replication (GO:0006268)5.48582769
18histone H4-K12 acetylation (GO:0043983)5.40839663
19negative regulation of epidermal cell differentiation (GO:0045605)5.13991935
20cytidine deamination (GO:0009972)5.04748701
21cytidine metabolic process (GO:0046087)5.04748701
22cytidine catabolic process (GO:0006216)5.04748701
23hormone catabolic process (GO:0042447)5.02821395
24mitotic sister chromatid segregation (GO:0000070)5.02689263
25formation of translation preinitiation complex (GO:0001731)5.02174290
26ribosomal small subunit biogenesis (GO:0042274)4.96530608
27heterochromatin organization (GO:0070828)4.91902209
28notochord development (GO:0030903)4.89503829
29rRNA methylation (GO:0031167)4.79438388
30phenol-containing compound catabolic process (GO:0019336)4.78624990
31regulation of cilium movement (GO:0003352)4.67563503
32DNA strand elongation involved in DNA replication (GO:0006271)4.66887652
33coenzyme catabolic process (GO:0009109)4.62080638
34response to dietary excess (GO:0002021)4.60268632
35protein localization to chromosome, centromeric region (GO:0071459)4.58145828
36ribosomal small subunit assembly (GO:0000028)4.56577732
37viral transcription (GO:0019083)4.55980022
38DNA strand elongation (GO:0022616)4.54146869
39DNA replication-dependent nucleosome assembly (GO:0006335)4.52574473
40DNA replication-dependent nucleosome organization (GO:0034723)4.52574473
41primitive streak formation (GO:0090009)4.47552274
42positive regulation of DNA-dependent DNA replication (GO:2000105)4.46477958
43regulation of translational fidelity (GO:0006450)4.43625192
44rRNA modification (GO:0000154)4.42409412
45nucleoside transmembrane transport (GO:1901642)4.41194253
46interferon-gamma production (GO:0032609)4.40954868
47regulation of apoptotic process involved in morphogenesis (GO:1902337)4.39659776
48quinone metabolic process (GO:1901661)4.39185339
49mitotic chromosome condensation (GO:0007076)4.37431827
50maturation of SSU-rRNA (GO:0030490)4.35403382
51chromatin assembly (GO:0031497)4.33849853
52translational termination (GO:0006415)4.32910786
53regulation of translation in response to stress (GO:0043555)4.23996566
54negative regulation of telomere maintenance (GO:0032205)4.23418433
55sister chromatid segregation (GO:0000819)4.17820419
56cellular modified amino acid catabolic process (GO:0042219)4.16509317
57DNA replication initiation (GO:0006270)4.16309901
58nuclear pore complex assembly (GO:0051292)4.15968983
59histone H4-K16 acetylation (GO:0043984)4.13855246
60telomere maintenance via semi-conservative replication (GO:0032201)4.13496716
61DNA replication checkpoint (GO:0000076)4.07890789
62epoxygenase P450 pathway (GO:0019373)3.98211644
63peptidyl-arginine omega-N-methylation (GO:0035247)3.95250538
64nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.94316366
65maintenance of protein localization in organelle (GO:0072595)3.90800017
66translational elongation (GO:0006414)3.90746800
67proline biosynthetic process (GO:0006561)3.90503772
68negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.86949956
69* regulation of mammary gland epithelial cell proliferation (GO:0033599)3.81888072
70ribonucleoprotein complex biogenesis (GO:0022613)3.78625140
71translational initiation (GO:0006413)3.74163153
72SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.71536864
73positive regulation of protein deacetylation (GO:0090312)3.70876396
74ribosomal large subunit biogenesis (GO:0042273)3.70813361
75regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.69021570
76mitochondrion distribution (GO:0048311)3.66912532
77negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.66458482
78intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.62299895
79nuclear pore organization (GO:0006999)3.62123904
80cotranslational protein targeting to membrane (GO:0006613)3.58423220
81pyrimidine ribonucleoside catabolic process (GO:0046133)3.57962184
82protein targeting to ER (GO:0045047)3.57082004
83cullin deneddylation (GO:0010388)3.56478098
84protein complex localization (GO:0031503)3.55080246
85nucleobase-containing small molecule interconversion (GO:0015949)3.54651613
86intestinal epithelial cell development (GO:0060576)3.53971257
87cell fate commitment involved in formation of primary germ layer (GO:0060795)3.53843894
88viral mRNA export from host cell nucleus (GO:0046784)3.52456263
89maternal placenta development (GO:0001893)3.51693678
90regulation of telomerase activity (GO:0051972)3.50866047
91viral life cycle (GO:0019058)3.50282367
92pre-miRNA processing (GO:0031054)3.49844290
93establishment of integrated proviral latency (GO:0075713)3.49482687
94retinoic acid receptor signaling pathway (GO:0048384)3.49157076
95vitamin A metabolic process (GO:0006776)3.48093213
96cardiovascular system development (GO:0072358)3.48063913
97histone arginine methylation (GO:0034969)3.46982465
98bone trabecula formation (GO:0060346)3.44882488
99pore complex assembly (GO:0046931)3.43767077
100establishment of protein localization to endoplasmic reticulum (GO:0072599)3.43204458
101cellular protein complex disassembly (GO:0043624)3.40909508
102telomere maintenance via recombination (GO:0000722)3.40841532
103RNA stabilization (GO:0043489)3.40834132
104mRNA stabilization (GO:0048255)3.40834132
105intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.36280096
106IMP biosynthetic process (GO:0006188)3.34883937
107ribosome assembly (GO:0042255)3.34694326
108regulation of telomere maintenance (GO:0032204)3.34639907
109DNA damage response, detection of DNA damage (GO:0042769)3.34386442
110arachidonic acid secretion (GO:0050482)3.34288818
111icosanoid secretion (GO:0032309)3.34288818
112protein localization to endoplasmic reticulum (GO:0070972)3.33911558
113GDP-mannose metabolic process (GO:0019673)3.33780668
114cellular protein complex localization (GO:0034629)3.33336069
115positive regulation of histone deacetylation (GO:0031065)3.32017895
116transcription from mitochondrial promoter (GO:0006390)3.31400830
117spliceosomal tri-snRNP complex assembly (GO:0000244)3.31225282
118ribosome biogenesis (GO:0042254)3.30953633
119microtubule severing (GO:0051013)3.30155731
120folic acid-containing compound biosynthetic process (GO:0009396)3.29487622
121peptidyl-arginine N-methylation (GO:0035246)3.27535979
122peptidyl-arginine methylation (GO:0018216)3.27535979
123mitotic nuclear envelope disassembly (GO:0007077)3.26834212
124mitotic metaphase plate congression (GO:0007080)3.26649178
125protein complex disassembly (GO:0043241)3.25794878
126nucleoside transport (GO:0015858)3.25284225
127trophectodermal cell differentiation (GO:0001829)3.24649122
128protein maturation by protein folding (GO:0022417)3.24069384
129apoptotic DNA fragmentation (GO:0006309)3.23978347
130omega-hydroxylase P450 pathway (GO:0097267)3.20574881
131regulation of gene silencing by RNA (GO:0060966)3.18233042
132regulation of posttranscriptional gene silencing (GO:0060147)3.18233042
133regulation of gene silencing by miRNA (GO:0060964)3.18233042
134phagocytosis, recognition (GO:0006910)3.17645095
135negative regulation of interleukin-2 production (GO:0032703)3.17449853
136mitotic recombination (GO:0006312)3.17227168
137COPI coating of Golgi vesicle (GO:0048205)3.16285266
138Golgi transport vesicle coating (GO:0048200)3.16285266
139transepithelial transport (GO:0070633)3.16282403
140cofactor transport (GO:0051181)3.14463497
141proline transport (GO:0015824)3.13817207
142protein polyglutamylation (GO:0018095)3.12941650
143protein deneddylation (GO:0000338)3.12292891
144regulation of translational termination (GO:0006449)3.11407389
145tachykinin receptor signaling pathway (GO:0007217)3.09873455
146macromolecular complex disassembly (GO:0032984)3.08433898
147signal transduction involved in regulation of gene expression (GO:0023019)3.07959798
148DNA duplex unwinding (GO:0032508)3.07856180
149negative regulation of RNA splicing (GO:0033119)3.07759511
150negative regulation of mRNA processing (GO:0050686)3.05384097
151IMP metabolic process (GO:0046040)3.04548965
152nuclear envelope disassembly (GO:0051081)3.04407181
153membrane disassembly (GO:0030397)3.04407181
154regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.02318602
155translation (GO:0006412)2.92912805
156L-serine metabolic process (GO:0006563)2.92730958
157rRNA processing (GO:0006364)2.90185567
158positive regulation of chromosome segregation (GO:0051984)2.89233966
159negative regulation of mRNA metabolic process (GO:1903312)2.89187551
160regulation of mitochondrial translation (GO:0070129)2.88528485
161DNA geometric change (GO:0032392)2.88109366
162chromatin assembly or disassembly (GO:0006333)2.86981619
163tRNA aminoacylation for protein translation (GO:0006418)2.86917102
164regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85322179
165mitochondrial fusion (GO:0008053)2.82407546
166deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.78385500
167nuclear-transcribed mRNA catabolic process (GO:0000956)2.78114501
168telomere maintenance via telomere lengthening (GO:0010833)2.76979083
169amino acid activation (GO:0043038)2.76445216
170tRNA aminoacylation (GO:0043039)2.76445216
171ncRNA 3-end processing (GO:0043628)2.73242682
172establishment of viral latency (GO:0019043)2.70822649
173nucleobase biosynthetic process (GO:0046112)2.70808884
174rRNA metabolic process (GO:0016072)2.70690992
175pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.69407475
176pentose-phosphate shunt (GO:0006098)2.67690123
177NADH metabolic process (GO:0006734)2.67662507
178folic acid metabolic process (GO:0046655)2.67261668
179mRNA catabolic process (GO:0006402)2.67000635
180protein targeting to membrane (GO:0006612)2.66983425
181peptidyl-lysine dimethylation (GO:0018027)2.66821136
182mitochondrial DNA metabolic process (GO:0032042)2.65283938
183polyketide metabolic process (GO:0030638)11.3791389
184doxorubicin metabolic process (GO:0044598)11.3791389
185daunorubicin metabolic process (GO:0044597)11.3791389

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.62461458
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.24526214
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.24526214
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.24526214
5E2F7_22180533_ChIP-Seq_HELA_Human4.36467807
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.31636329
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.44731480
8NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.19897552
9TP63_19390658_ChIP-ChIP_HaCaT_Human3.08714999
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.92109821
11SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.81431058
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.78582727
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.68647129
14TCF3_18692474_ChIP-Seq_MEFs_Mouse2.48528904
15TCF3_18692474_ChIP-Seq_MESCs_Mouse2.48152422
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.40805016
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.34852279
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.33558887
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27458735
20* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.26762071
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.15791927
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13888312
23* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.03598679
24NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.03468627
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.01238001
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.95840884
27NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.93099651
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.92572487
29NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.91360990
30CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.90278844
31STAT3_1855785_ChIP-Seq_MESCs_Mouse1.89988288
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.88562348
33DCP1A_22483619_ChIP-Seq_HELA_Human1.87785517
34VDR_21846776_ChIP-Seq_THP-1_Human1.85939125
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.82778347
36ZNF263_19887448_ChIP-Seq_K562_Human1.82756111
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.82541129
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.82504688
39IRF1_19129219_ChIP-ChIP_H3396_Human1.80955648
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78328883
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.75926194
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73828768
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.72103414
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.68943208
45* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68556894
46TTF2_22483619_ChIP-Seq_HELA_Human1.67385450
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66219336
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.65842851
49POU5F1_16518401_ChIP-PET_MESCs_Mouse1.61868820
50CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.61460031
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59165382
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58122734
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56253704
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.55066142
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54807751
56* GABP_19822575_ChIP-Seq_HepG2_Human1.54455448
57TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.53832976
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.50745847
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50356791
60NANOG_18692474_ChIP-Seq_MEFs_Mouse1.44598436
61HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.43165547
62NANOG_18692474_ChIP-Seq_MESCs_Mouse1.41383349
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.40946092
64* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40754428
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39448345
66MYC_22102868_ChIP-Seq_BL_Human1.38357700
67* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.37854262
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36975628
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35691818
70CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35578822
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34535471
72GABP_17652178_ChIP-ChIP_JURKAT_Human1.33862288
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33747928
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33455934
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33003010
76CDX2_20551321_ChIP-Seq_CACO-2_Human1.30892684
77* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.30679262
78PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.30035351
79* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28453473
80* FOXP3_21729870_ChIP-Seq_TREG_Human1.28295055
81CIITA_25753668_ChIP-Seq_RAJI_Human1.27704083
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27470830
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26144566
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23942033
85SOX2_18692474_ChIP-Seq_MESCs_Mouse1.23728835
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22989983
87* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.22820911
88* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21168585
89SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19658673
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.17756515
91SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.16377249
92CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16097286
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14147530
94NANOG_16518401_ChIP-PET_MESCs_Mouse1.13278407
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12425474
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12337168
97VDR_23849224_ChIP-Seq_CD4+_Human1.10561002
98* YY1_21170310_ChIP-Seq_MESCs_Mouse1.09695339
99CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08983877
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06917042
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.06295261
102* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05875923
103TET1_21451524_ChIP-Seq_MESCs_Mouse1.04481261
104ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04364703
105TFEB_21752829_ChIP-Seq_HELA_Human1.04113984
106TP53_22127205_ChIP-Seq_IMR90_Human1.04011953
107E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01849665
108NCOR1_26117541_ChIP-Seq_K562_Human1.01648494
109TP63_17297297_ChIP-ChIP_HaCaT_Human1.01576811
110KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01001551
111TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00349137
112SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00141315
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99991294
114NANOG_21062744_ChIP-ChIP_HESCs_Human0.98663443
115FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98435930
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98411331
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98386689
118* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97158664
119PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95562500
120TCF7_22412390_ChIP-Seq_EML_Mouse0.95065164
121KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94337763
122CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93982313
123CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92736701
124SRF_21415370_ChIP-Seq_HL-1_Mouse0.92588619
125CHD1_26751641_Chip-Seq_LNCaP_Human0.92512733
126SCL_19346495_ChIP-Seq_HPC-7_Human0.88444719
127KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87880563
128POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86973820
129KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86782352
130ELK3_25401928_ChIP-Seq_HUVEC_Human0.83920133
131KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83126037
132KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.82740946
133E2F1_18555785_ChIP-Seq_MESCs_Mouse0.81390988
134EST1_17652178_ChIP-ChIP_JURKAT_Human0.79321019
135SMC4_20622854_ChIP-Seq_HELA_Human0.78729715
136YY1_22570637_ChIP-Seq_MALME-3M_Human0.78697422
137POU5F1_16153702_ChIP-ChIP_HESCs_Human0.78170279
138PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78016934
139CTCF_21964334_Chip-Seq_Bcells_Human0.77856565
140TBX3_20139965_ChIP-Seq_ESCs_Mouse0.77355987
141RACK7_27058665_Chip-Seq_MCF-7_Human0.76783045
142* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.76270755
143TBX3_20139965_ChIP-Seq_MESCs_Mouse0.76071529
144KAP1_27257070_Chip-Seq_ESCs_Mouse0.74747744
145SRY_22984422_ChIP-ChIP_TESTIS_Rat0.73679897
146ELF1_20517297_ChIP-Seq_JURKAT_Human0.72883942
147SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.71068687
148LXR_22292898_ChIP-Seq_THP-1_Human0.70581904
149KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.69700987
150* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.69062044
151STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.68894861
152FOXO3_23340844_ChIP-Seq_DLD1_Human0.67998770
153KDM5A_27292631_Chip-Seq_BREAST_Human0.67780921
154AR_21909140_ChIP-Seq_LNCAP_Human0.67735792
155P68_20966046_ChIP-Seq_HELA_Human0.65794286
156EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.65605226
157WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.64777469
158XRN2_22483619_ChIP-Seq_HELA_Human0.64629267
159ESR1_15608294_ChIP-ChIP_MCF-7_Human0.64519905

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.89602133
2MP0002254_reproductive_system_inflammat4.78137135
3MP0004264_abnormal_extraembryonic_tissu4.37779658
4MP0006292_abnormal_olfactory_placode4.26200258
5MP0003890_abnormal_embryonic-extraembry3.58034519
6MP0005499_abnormal_olfactory_system3.45601390
7MP0005394_taste/olfaction_phenotype3.45601390
8MP0004858_abnormal_nervous_system3.33066739
9MP0005075_abnormal_melanosome_morpholog3.18073845
10MP0003122_maternal_imprinting3.07475382
11MP0008057_abnormal_DNA_replication2.91926349
12MP0002332_abnormal_exercise_endurance2.84074016
13MP0003705_abnormal_hypodermis_morpholog2.74738606
14MP0004957_abnormal_blastocyst_morpholog2.74063887
15MP0005257_abnormal_intraocular_pressure2.56178895
16MP0005451_abnormal_body_composition2.48671442
17MP0010352_gastrointestinal_tract_polyps2.34168460
18MP0003121_genomic_imprinting2.27665558
19MP0002877_abnormal_melanocyte_morpholog2.20263581
20MP0002653_abnormal_ependyma_morphology2.18298971
21MP0008058_abnormal_DNA_repair2.13805743
22MP0004185_abnormal_adipocyte_glucose2.09825896
23MP0000678_abnormal_parathyroid_gland2.06959404
24MP0004233_abnormal_muscle_weight1.95980578
25MP0010234_abnormal_vibrissa_follicle1.94375566
26MP0001672_abnormal_embryogenesis/_devel1.86331892
27MP0005380_embryogenesis_phenotype1.86331892
28MP0000537_abnormal_urethra_morphology1.86034267
29MP0001661_extended_life_span1.85687787
30MP0003938_abnormal_ear_development1.83930738
31MP0008961_abnormal_basal_metabolism1.79510390
32MP0002088_abnormal_embryonic_growth/wei1.75624592
33MP0003984_embryonic_growth_retardation1.73277241
34MP0010030_abnormal_orbit_morphology1.73254149
35MP0002277_abnormal_respiratory_mucosa1.70905879
36MP0009379_abnormal_foot_pigmentation1.70084731
37MP0002127_abnormal_cardiovascular_syste1.66284461
38MP0003183_abnormal_peptide_metabolism1.65951342
39MP0005076_abnormal_cell_differentiation1.58203221
40MP0001849_ear_inflammation1.56924408
41MP0005501_abnormal_skin_physiology1.56198072
42MP0001293_anophthalmia1.56065479
43MP0003123_paternal_imprinting1.53271226
44MP0009672_abnormal_birth_weight1.53031961
45MP0002932_abnormal_joint_morphology1.52976149
46MP0002796_impaired_skin_barrier1.49970858
47MP0006082_CNS_inflammation1.49015260
48MP0008260_abnormal_autophagy1.44317698
49MP0003786_premature_aging1.43410955
50MP0000762_abnormal_tongue_morphology1.43252701
51MP0002092_abnormal_eye_morphology1.41793070
52MP0010307_abnormal_tumor_latency1.37154254
53MP0005266_abnormal_metabolism1.35959465
54* MP0006035_abnormal_mitochondrial_morpho1.35912638
55MP0003077_abnormal_cell_cycle1.34552189
56MP0000049_abnormal_middle_ear1.33338749
57MP0008789_abnormal_olfactory_epithelium1.31804622
58MP0002086_abnormal_extraembryonic_tissu1.31485304
59MP0004043_abnormal_pH_regulation1.29816079
60MP0002085_abnormal_embryonic_tissue1.24921047
61MP0002396_abnormal_hematopoietic_system1.24384514
62* MP0000350_abnormal_cell_proliferation1.23110725
63MP0002233_abnormal_nose_morphology1.22276561
64MP0000733_abnormal_muscle_development1.19460725
65MP0001348_abnormal_lacrimal_gland1.18281209
66MP0003221_abnormal_cardiomyocyte_apopto1.14535375
67MP0004808_abnormal_hematopoietic_stem1.14521649
68MP0003941_abnormal_skin_development1.14168009
69MP0009333_abnormal_splenocyte_physiolog1.13393422
70MP0009697_abnormal_copulation1.13336236
71MP0002009_preneoplasia1.11077863
72MP0002970_abnormal_white_adipose1.10498169
73MP0002114_abnormal_axial_skeleton1.10108918
74MP0000428_abnormal_craniofacial_morphol1.07537183
75MP0003111_abnormal_nucleus_morphology1.07530425
76MP0002084_abnormal_developmental_patter1.06833969
77MP0003566_abnormal_cell_adhesion1.05525859
78MP0000747_muscle_weakness1.04930541
79MP0002019_abnormal_tumor_incidence1.03260744
80MP0003119_abnormal_digestive_system0.99931607
81MP0005248_abnormal_Harderian_gland0.99582381
82MP0005666_abnormal_adipose_tissue0.99393566
83* MP0000358_abnormal_cell_content/0.98863344
84MP0004133_heterotaxia0.98748033
85MP0004381_abnormal_hair_follicle0.98473694
86MP0004197_abnormal_fetal_growth/weight/0.98267521
87MP0000432_abnormal_head_morphology0.97957702
88MP0003935_abnormal_craniofacial_develop0.97932426
89MP0008770_decreased_survivor_rate0.96935795
90MP0003283_abnormal_digestive_organ0.96785026
91MP0003137_abnormal_impulse_conducting0.95542291
92MP0003315_abnormal_perineum_morphology0.95456442
93MP0001730_embryonic_growth_arrest0.93652710
94MP0003755_abnormal_palate_morphology0.93303207
95MP0000759_abnormal_skeletal_muscle0.93206863
96MP0002697_abnormal_eye_size0.92927037
97MP0008438_abnormal_cutaneous_collagen0.90990529
98MP0001346_abnormal_lacrimal_gland0.90911427
99MP0000003_abnormal_adipose_tissue0.90408571
100MP0005621_abnormal_cell_physiology0.90129032
101MP0005058_abnormal_lysosome_morphology0.89472536
102MP0002089_abnormal_postnatal_growth/wei0.88866224
103MP0000490_abnormal_crypts_of0.87674166
104MP0002132_abnormal_respiratory_system0.87181008
105MP0003453_abnormal_keratinocyte_physiol0.86609917
106MP0003567_abnormal_fetal_cardiomyocyte0.86311813
107MP0000750_abnormal_muscle_regeneration0.86157100
108MP0001697_abnormal_embryo_size0.85134983
109MP0010094_abnormal_chromosome_stability0.84416673
110MP0003718_maternal_effect0.84385223
111MP0010630_abnormal_cardiac_muscle0.83747372
112MP0005391_vision/eye_phenotype0.83661792
113* MP0005384_cellular_phenotype0.82990101
114MP0002060_abnormal_skin_morphology0.82797067
115MP0002925_abnormal_cardiovascular_devel0.81499553
116MP0000749_muscle_degeneration0.81137439
117MP0005508_abnormal_skeleton_morphology0.80902973
118MP0002163_abnormal_gland_morphology0.80865113
119MP0000703_abnormal_thymus_morphology0.80493010
120MP0003763_abnormal_thymus_physiology0.79937709
121MP0004087_abnormal_muscle_fiber0.79570960
122MP0002269_muscular_atrophy0.79423138
123* MP0000313_abnormal_cell_death0.78647116
124* MP0002080_prenatal_lethality0.78385024
125MP0005330_cardiomyopathy0.77870065
126MP0000751_myopathy0.76758635
127MP0005023_abnormal_wound_healing0.76075745
128MP0008932_abnormal_embryonic_tissue0.75762817
129MP0005375_adipose_tissue_phenotype0.72721590
130MP0003942_abnormal_urinary_system0.71927454
131MP0003385_abnormal_body_wall0.71468437
132MP0004272_abnormal_basement_membrane0.71398981
133MP0000477_abnormal_intestine_morphology0.70490681
134MP0002116_abnormal_craniofacial_bone0.69823635
135MP0002751_abnormal_autonomic_nervous0.69423472
136MP0003115_abnormal_respiratory_system0.68970859
137MP0002249_abnormal_larynx_morphology0.68539081
138MP0009703_decreased_birth_body0.68413247
139MP0002098_abnormal_vibrissa_morphology0.68085616
140MP0001727_abnormal_embryo_implantation0.67809248
141MP0002166_altered_tumor_susceptibility0.66830007
142MP0001216_abnormal_epidermal_layer0.66278897
143MP0005319_abnormal_enzyme/_coenzyme0.65696850
144MP0008007_abnormal_cellular_replicative0.63654308
145MP0003937_abnormal_limbs/digits/tail_de0.63221551
146MP0006036_abnormal_mitochondrial_physio0.63159575
147MP0001286_abnormal_eye_development0.59750946
148MP0003787_abnormal_imprinting0.58573740
149MP0002081_perinatal_lethality0.55728586
150MP0000377_abnormal_hair_follicle0.55684316
151MP0002111_abnormal_tail_morphology0.55316355
152MP0004883_abnormal_blood_vessel0.54520573
153MP0005623_abnormal_meninges_morphology0.52890560
154MP0003693_abnormal_embryo_hatching0.52239410
155MP0005197_abnormal_uvea_morphology0.51669105
156MP0003806_abnormal_nucleotide_metabolis0.51019972
157MP0010368_abnormal_lymphatic_system0.50075765

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.74797747
2Hypochromic microcytic anemia (HP:0004840)6.13965500
3Multiple enchondromatosis (HP:0005701)5.62259041
4Hepatoblastoma (HP:0002884)5.61150964
5Abnormality of the lower motor neuron (HP:0002366)5.01937708
6Rib fusion (HP:0000902)4.79174884
7Ependymoma (HP:0002888)4.35662358
8Neoplasm of striated muscle (HP:0009728)3.79935927
9Rhabdomyosarcoma (HP:0002859)3.62677472
10Nephroblastoma (Wilms tumor) (HP:0002667)3.59792453
11Testicular atrophy (HP:0000029)3.58161586
12Reticulocytopenia (HP:0001896)3.56445428
13Abnormality of cells of the erythroid lineage (HP:0012130)3.51692289
14Aplasia/Hypoplasia of the fovea (HP:0008060)3.42343109
15Hypoplasia of the fovea (HP:0007750)3.42343109
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.40304101
17Partial duplication of thumb phalanx (HP:0009944)3.40279770
18Rectal fistula (HP:0100590)3.39711607
19Rectovaginal fistula (HP:0000143)3.39711607
20Ragged-red muscle fibers (HP:0003200)3.35076903
21Embryonal renal neoplasm (HP:0011794)3.33176896
22Fused cervical vertebrae (HP:0002949)3.32306672
23Hyperinsulinemic hypoglycemia (HP:0000825)3.24562694
24Bifid tongue (HP:0010297)3.19157044
25Abnormality of the salivary glands (HP:0010286)3.12675779
26Abnormal cartilage morphology (HP:0002763)3.11787910
27Astrocytoma (HP:0009592)3.07807424
28Abnormality of the astrocytes (HP:0100707)3.07807424
29Amyotrophic lateral sclerosis (HP:0007354)3.04785543
30Intestinal fistula (HP:0100819)3.03448867
31Trismus (HP:0000211)3.00641499
32Vaginal fistula (HP:0004320)2.99190185
33Partial duplication of the phalanx of hand (HP:0009999)2.99144192
34Abnormal number of erythroid precursors (HP:0012131)2.98832282
35Aplasia/hypoplasia of the humerus (HP:0006507)2.98121307
36Short humerus (HP:0005792)2.94074160
37Anomalous pulmonary venous return (HP:0010772)2.93288178
38Abnormal lung lobation (HP:0002101)2.90905370
39Chromsome breakage (HP:0040012)2.86236919
40Hyperacusis (HP:0010780)2.83794915
41Selective tooth agenesis (HP:0001592)2.79952678
42Horizontal nystagmus (HP:0000666)2.75726231
43Reduced antithrombin III activity (HP:0001976)2.72688356
44Abnormality of glycolysis (HP:0004366)2.72099694
45Preauricular skin tag (HP:0000384)2.70902502
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.66455667
47Hypochromic anemia (HP:0001931)2.60392632
48Preauricular pit (HP:0004467)2.60215483
49Periauricular skin pits (HP:0100277)2.60215483
50Rough bone trabeculation (HP:0100670)2.57032262
51Abnormality of the fovea (HP:0000493)2.55692495
52Generalized hypotonia (HP:0001290)2.55510996
53Progressive muscle weakness (HP:0003323)2.50327840
54Abnormality of the pulmonary veins (HP:0011718)2.48957109
55Abnormality of the phalanges of the hallux (HP:0010057)2.46541838
56Large earlobe (HP:0009748)2.43042381
57Increased connective tissue (HP:0009025)2.42433271
58Hyperventilation (HP:0002883)2.41604935
59Abnormality of the umbilical cord (HP:0010881)2.40060954
60Skin tags (HP:0010609)2.39742609
61Tetraplegia (HP:0002445)2.37723513
62Sensory axonal neuropathy (HP:0003390)2.37055658
63Macrocytic anemia (HP:0001972)2.35633657
64Short 5th finger (HP:0009237)2.33203442
65Nasolacrimal duct obstruction (HP:0000579)2.31430674
66Increased serum pyruvate (HP:0003542)2.31411153
67Shawl scrotum (HP:0000049)2.31089045
68Difficulty running (HP:0009046)2.30659278
69Impulsivity (HP:0100710)2.30067222
70Aplasia/Hypoplasia of the macula (HP:0008059)2.28161535
71Centrally nucleated skeletal muscle fibers (HP:0003687)2.27986481
72Meckel diverticulum (HP:0002245)2.26130012
73Birth length less than 3rd percentile (HP:0003561)2.23788429
74Glioma (HP:0009733)2.23234616
75Insomnia (HP:0100785)2.22973593
76Abnormality of the pubic bones (HP:0003172)2.22633587
77Microretrognathia (HP:0000308)2.21321377
78Abnormality of the distal phalanx of the thumb (HP:0009617)2.20784354
79Abnormality of the fetal cardiovascular system (HP:0010948)2.19995407
80Abnormal umbilical cord blood vessels (HP:0011403)2.19995407
81Single umbilical artery (HP:0001195)2.19995407
82Pendular nystagmus (HP:0012043)2.18963183
83Asymmetry of the thorax (HP:0001555)2.18848967
84Abnormality of chromosome segregation (HP:0002916)2.18693299
85Abnormality of small intestinal villus morphology (HP:0011472)2.18603500
86Villous atrophy (HP:0011473)2.18603500
87Renal duplication (HP:0000075)2.18431021
88Neoplasm of the heart (HP:0100544)2.17997360
89Upper motor neuron abnormality (HP:0002127)2.17875957
90Hypopigmentation of the fundus (HP:0007894)2.17780042
91Supernumerary spleens (HP:0009799)2.17113901
92Abnormality of the musculature of the hand (HP:0001421)2.16905216
93Squamous cell carcinoma (HP:0002860)2.15384312
94Tongue fasciculations (HP:0001308)2.13773051
95Aplasia/Hypoplasia of the uvula (HP:0010293)2.13712954
96Glossoptosis (HP:0000162)2.13238809
97Abnormality of the preputium (HP:0100587)2.12566497
98Vertebral compression fractures (HP:0002953)2.12077844
99Pseudobulbar signs (HP:0002200)2.11762986
100Abnormality of the intrinsic pathway (HP:0010989)2.11679260
101Abnormality of reticulocytes (HP:0004312)2.10821369
102Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.10488519
103Abnormality of the ileum (HP:0001549)2.10085305
104Hand muscle atrophy (HP:0009130)2.08965975
105Cholecystitis (HP:0001082)2.08639785
106Abnormal gallbladder physiology (HP:0012438)2.08639785
107Proximal placement of thumb (HP:0009623)2.07234770
108High anterior hairline (HP:0009890)2.06153743
109Myopathic facies (HP:0002058)2.05799359
110Aplasia/Hypoplasia affecting the retina (HP:0008061)2.05293458
111Deviation of the thumb (HP:0009603)2.05049095
112Malignant neoplasm of the central nervous system (HP:0100836)2.04847561
113Skin pits (HP:0100276)2.03499207
114Malnutrition (HP:0004395)2.03234391
115Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.02324177
116Achilles tendon contracture (HP:0001771)2.00725974
117Premature ovarian failure (HP:0008209)2.00181824
118Aplasia/Hypoplasia of the sternum (HP:0006714)1.98909000
119Facial cleft (HP:0002006)1.97616389
120Microvesicular hepatic steatosis (HP:0001414)1.96866308
121Cheilitis (HP:0100825)1.96605634
122Progressive external ophthalmoplegia (HP:0000590)1.96557137
123Calcaneovalgus deformity (HP:0001848)1.96391139
124Muscle fibrillation (HP:0010546)1.96181666
125Rhabdomyolysis (HP:0003201)1.95953857
126Abnormality of the calcaneus (HP:0008364)1.95097165
127Increased nuchal translucency (HP:0010880)1.94849678
128Abnormal trabecular bone morphology (HP:0100671)1.94816251
129Vertebral fusion (HP:0002948)1.94376439
130Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.94355081
131Adenoma sebaceum (HP:0009720)1.93403725
132Angiofibromas (HP:0010615)1.93403725
133Upper limb muscle weakness (HP:0003484)1.92122162
134Pallor (HP:0000980)1.92079216
135Skin nodule (HP:0200036)1.91891783
136Hypoplastic scapulae (HP:0000882)1.91755297
137Broad distal phalanx of finger (HP:0009836)1.89381639
138Breast hypoplasia (HP:0003187)1.88200852
139Colitis (HP:0002583)1.85930972
140Overriding aorta (HP:0002623)1.85303522
141Abnormalities of placenta or umbilical cord (HP:0001194)1.83961478
142Long palpebral fissure (HP:0000637)1.82177267
143Spastic diplegia (HP:0001264)1.77704830
144Deep palmar crease (HP:0006191)1.76396137
145Secondary amenorrhea (HP:0000869)1.75902774
146Abnormality of the thoracic spine (HP:0100711)1.73383586
147Gout (HP:0001997)1.73024817
148Horseshoe kidney (HP:0000085)1.72901222
149Abnormality of the distal phalanges of the toes (HP:0010182)1.72777393
150Sparse lateral eyebrow (HP:0005338)1.71701839
151Septate vagina (HP:0001153)1.71463323
152Rectal prolapse (HP:0002035)1.70003007
153Ureteral duplication (HP:0000073)1.67766308
154Premature skin wrinkling (HP:0100678)1.66491955
155Abnormality of the Achilles tendon (HP:0005109)1.66143702
156Duplication of thumb phalanx (HP:0009942)1.66121278
157IgA deficiency (HP:0002720)1.65539426
158Oral leukoplakia (HP:0002745)1.65028087
159Breech presentation (HP:0001623)1.64439119
160Abnormality of cochlea (HP:0000375)1.64142812
161Myelodysplasia (HP:0002863)1.63866263
162Ulnar bowing (HP:0003031)1.63400985
163Atresia of the external auditory canal (HP:0000413)1.63386226
164Ankyloglossia (HP:0010296)1.63282160
165Hypergonadotropic hypogonadism (HP:0000815)1.62668303
166Abnormality of pyrimidine metabolism (HP:0004353)1.62508118
167Flat acetabular roof (HP:0003180)1.62434691
168Dysmetric saccades (HP:0000641)1.62191947
169Exercise-induced myalgia (HP:0003738)1.57543049
170IgM deficiency (HP:0002850)1.56580408
171Decreased activity of mitochondrial respiratory chain (HP:0008972)1.55828532
172Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.55828532
173Overlapping toe (HP:0001845)1.55508096
174Truncus arteriosus (HP:0001660)1.54665571
175Deformed tarsal bones (HP:0008119)1.54218461
176Muscle stiffness (HP:0003552)1.53839539
177Distal lower limb amyotrophy (HP:0008944)1.53745966
178Orthostatic hypotension (HP:0001278)1.53609168
179Microglossia (HP:0000171)1.52105160
180Medulloblastoma (HP:0002885)1.51551487
181Disproportionate tall stature (HP:0001519)1.51410323
182Spinal cord lesions (HP:0100561)1.50527100
183Syringomyelia (HP:0003396)1.50527100

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.37479139
2GRK55.52378125
3ERN14.81676273
4GRK64.64434963
5NME24.15279507
6SMG13.79295248
7GRK13.36200814
8ADRBK23.31642483
9EEF2K3.15020830
10CSF1R2.98833050
11TGFBR22.74162003
12TYRO32.62721870
13TTK2.53690651
14ZAK2.49877906
15GRK72.41755833
16MAPK72.35188067
17PBK2.33749906
18SCYL22.31994849
19STK102.29026120
20MATK2.24167955
21VRK22.14503141
22MOS2.07113278
23PRPF4B2.05663211
24SRPK12.04755420
25WNK11.98248388
26TLK11.98060563
27IRAK31.83963463
28CDK71.54021395
29PRKG21.49441914
30NTRK11.48703599
31VRK11.47369552
32EPHA21.33597866
33PAK41.32579270
34MAP3K101.31919502
35STK41.30107360
36EIF2AK11.29647048
37PKN21.25909806
38TSSK61.25794014
39MARK21.23723061
40STK161.18816531
41KDR1.17544433
42MAP2K41.14889399
43CHEK21.13840487
44ADRBK11.12829655
45HIPK21.11970970
46BRAF1.09088257
47ARAF1.08096993
48CDK81.06380038
49PLK11.03446033
50FGFR31.03138454
51RPS6KA50.99998410
52ATR0.98282467
53AKT30.97281768
54BRSK10.90105547
55PDK20.89440995
56LRRK20.88078033
57PIM20.87987019
58TTN0.87467498
59FGFR40.84987442
60MAP2K30.82920693
61CDK60.82644655
62NME10.82588429
63MST1R0.82241618
64CDK190.80842475
65ALK0.80717047
66MAPK110.80359157
67AKT20.80212044
68MAP2K60.79628901
69DAPK30.78097398
70CSK0.75890792
71ILK0.75866901
72MAP3K70.74966454
73CHEK10.72620949
74EIF2AK30.71275644
75PLK40.70550391
76MAPK120.69904571
77LATS20.69547738
78TAF10.66504626
79PASK0.62350485
80MELK0.60173660
81EIF2AK20.59432086
82CDC70.59043494
83KSR20.58169802
84RPS6KA40.57449123
85PIM10.57116371
86MTOR0.56526736
87NEK20.56184885
88CDK90.54480906
89CLK10.53974618
90RPS6KB20.51901386
91DAPK10.48870645
92TESK10.48510823
93CCNB10.47155113
94BCKDK0.46271990
95PRKCI0.44337816
96PRKD30.43962853
97CDK20.43459495
98RAF10.43094497
99AURKA0.42862970
100LMTK20.42185605
101PTK20.41602206
102BUB10.41371115
103IGF1R0.41341088
104CDK40.39953091
105CSNK2A20.39869191
106WEE10.39243401
107PDGFRA0.37824404
108RIPK10.37102444
109ITK0.37041202
110BRD40.36970378
111MAP2K20.36924277
112ERBB20.34805695
113MAP3K110.34304224
114MAP3K90.33189348
115PTK60.33040148
116PAK10.32748436
117MET0.32605950
118NEK10.32428221
119IRAK20.32341525
120CSNK1E0.31189841
121PRKCD0.31107539
122AURKB0.31057071
123PAK20.30830003
124ATM0.28952112
125SIK10.28879304
126BMX0.28250481
127IKBKB0.25405999
128MAPKAPK30.24842083
129MAPK100.23971587
130INSR0.22156076
131CDK10.21920959
132DYRK30.21429264
133TESK20.20854122
134MAPK40.19722913
135PRKACG0.19295224
136STK380.18421065
137MAPK10.18297665
138GSK3B0.16990580
139CDK150.16599828
140GSK3A0.16484882
141PRKD20.16213018
142DYRK20.16006405
143MAPK140.15677330
144ICK0.15368793
145TAOK20.15204067
146CDK11A0.14723441
147PRKACB0.14313522
148PRKAA10.13881968
149TAOK10.13223700
150CDK180.12554616
151PAK30.12217657
152DDR20.12164754
153DYRK1A0.10919027
154MAP3K80.10406362
155DYRK1B0.09811678
156PRKCG0.09213450
157PRKACA0.08595287
158TRIB30.08244569
159MAPKAPK20.08056803
160CHUK0.07925893
161RPS6KA30.07682923
162FLT30.07567510

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.67606985
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006036.10525561
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.13510083
4Fructose and mannose metabolism_Homo sapiens_hsa000514.01940655
5Systemic lupus erythematosus_Homo sapiens_hsa053223.12473355
6Galactose metabolism_Homo sapiens_hsa000522.84586110
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.65295709
8Arachidonic acid metabolism_Homo sapiens_hsa005902.60642205
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.57797567
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24373197
11Alcoholism_Homo sapiens_hsa050342.14484298
12Linoleic acid metabolism_Homo sapiens_hsa005912.12731141
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.02960387
14Nucleotide excision repair_Homo sapiens_hsa034202.00205405
15Proteasome_Homo sapiens_hsa030501.89152014
16Pyrimidine metabolism_Homo sapiens_hsa002401.82059498
17RNA transport_Homo sapiens_hsa030131.70318694
18Thyroid cancer_Homo sapiens_hsa052161.63609036
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.60905006
20Viral carcinogenesis_Homo sapiens_hsa052031.60695981
21Non-homologous end-joining_Homo sapiens_hsa034501.58322477
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55278593
23mTOR signaling pathway_Homo sapiens_hsa041501.55254958
24One carbon pool by folate_Homo sapiens_hsa006701.46593247
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33897600
26DNA replication_Homo sapiens_hsa030301.28092202
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.27674367
28Chemical carcinogenesis_Homo sapiens_hsa052041.25655849
29mRNA surveillance pathway_Homo sapiens_hsa030151.22913642
30Fanconi anemia pathway_Homo sapiens_hsa034601.16728917
31Ribosome_Homo sapiens_hsa030101.16405402
32Pyruvate metabolism_Homo sapiens_hsa006201.15579116
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11877079
34Cell cycle_Homo sapiens_hsa041101.06768225
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05772906
36Chronic myeloid leukemia_Homo sapiens_hsa052201.04893932
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02507936
38Pentose phosphate pathway_Homo sapiens_hsa000300.97510133
39Tryptophan metabolism_Homo sapiens_hsa003800.96944717
40Mismatch repair_Homo sapiens_hsa034300.96825956
41Sulfur relay system_Homo sapiens_hsa041220.95134435
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94845822
43Glycosaminoglycan degradation_Homo sapiens_hsa005310.94834036
44Other glycan degradation_Homo sapiens_hsa005110.91956589
45RNA degradation_Homo sapiens_hsa030180.91262203
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90772846
47N-Glycan biosynthesis_Homo sapiens_hsa005100.90629698
48Central carbon metabolism in cancer_Homo sapiens_hsa052300.89859964
49Folate biosynthesis_Homo sapiens_hsa007900.88287397
50Ovarian steroidogenesis_Homo sapiens_hsa049130.87351912
51Purine metabolism_Homo sapiens_hsa002300.87059252
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.86422018
53Carbon metabolism_Homo sapiens_hsa012000.83081631
54Arginine biosynthesis_Homo sapiens_hsa002200.80668315
55Inositol phosphate metabolism_Homo sapiens_hsa005620.79132188
56Homologous recombination_Homo sapiens_hsa034400.78351222
57Basal cell carcinoma_Homo sapiens_hsa052170.78208666
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75235352
59Epstein-Barr virus infection_Homo sapiens_hsa051690.73904602
60Spliceosome_Homo sapiens_hsa030400.72938725
61Biosynthesis of amino acids_Homo sapiens_hsa012300.72913231
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72469429
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72348247
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71933631
65Ether lipid metabolism_Homo sapiens_hsa005650.69524089
66p53 signaling pathway_Homo sapiens_hsa041150.68554878
67HTLV-I infection_Homo sapiens_hsa051660.68350883
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68263166
69Pathways in cancer_Homo sapiens_hsa052000.68079958
70Small cell lung cancer_Homo sapiens_hsa052220.67914968
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66693795
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66561623
73Acute myeloid leukemia_Homo sapiens_hsa052210.66554001
74MicroRNAs in cancer_Homo sapiens_hsa052060.64052864
75Arginine and proline metabolism_Homo sapiens_hsa003300.62913029
76Hedgehog signaling pathway_Homo sapiens_hsa043400.61467875
77Complement and coagulation cascades_Homo sapiens_hsa046100.61293071
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60366700
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60117877
80Fatty acid elongation_Homo sapiens_hsa000620.60071076
81Colorectal cancer_Homo sapiens_hsa052100.58157500
82Bladder cancer_Homo sapiens_hsa052190.56233902
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56143638
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55890178
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55729363
86Huntingtons disease_Homo sapiens_hsa050160.54328613
87Choline metabolism in cancer_Homo sapiens_hsa052310.53476108
88Rap1 signaling pathway_Homo sapiens_hsa040150.53169257
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53012411
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52400696
91Non-small cell lung cancer_Homo sapiens_hsa052230.52201365
92Base excision repair_Homo sapiens_hsa034100.51487302
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.50553761
94Glutathione metabolism_Homo sapiens_hsa004800.49199492
95Selenocompound metabolism_Homo sapiens_hsa004500.49118578
96Endometrial cancer_Homo sapiens_hsa052130.49032742
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48291059
98Parkinsons disease_Homo sapiens_hsa050120.47152873
99Hippo signaling pathway_Homo sapiens_hsa043900.44799690
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44351720
101AMPK signaling pathway_Homo sapiens_hsa041520.43518478
102Oocyte meiosis_Homo sapiens_hsa041140.42075904
103African trypanosomiasis_Homo sapiens_hsa051430.41959482
104Insulin signaling pathway_Homo sapiens_hsa049100.41248780
105Herpes simplex infection_Homo sapiens_hsa051680.40204260
106Basal transcription factors_Homo sapiens_hsa030220.40082806
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38336692
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.37825947
109Phenylalanine metabolism_Homo sapiens_hsa003600.37685363
110Prostate cancer_Homo sapiens_hsa052150.37296029
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.35881121
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35036662
113B cell receptor signaling pathway_Homo sapiens_hsa046620.34019197
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33888718
115Glioma_Homo sapiens_hsa052140.33307233
116HIF-1 signaling pathway_Homo sapiens_hsa040660.32719409
117Retinol metabolism_Homo sapiens_hsa008300.30756259
118Hepatitis B_Homo sapiens_hsa051610.30745842
119Proteoglycans in cancer_Homo sapiens_hsa052050.30738037
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.30598579
121Notch signaling pathway_Homo sapiens_hsa043300.30104381
122Apoptosis_Homo sapiens_hsa042100.29728833
123RNA polymerase_Homo sapiens_hsa030200.29521129
124Shigellosis_Homo sapiens_hsa051310.29496020
125VEGF signaling pathway_Homo sapiens_hsa043700.28952256
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.28923617
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28906841
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28260507
129Prion diseases_Homo sapiens_hsa050200.27990712
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24981656
131Wnt signaling pathway_Homo sapiens_hsa043100.22535102
132Tight junction_Homo sapiens_hsa045300.22124966
133Metabolic pathways_Homo sapiens_hsa011000.22103033
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21770376
135Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21555287
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21448960
137Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21353597
138Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19366105
139Lysine degradation_Homo sapiens_hsa003100.19320217
140PPAR signaling pathway_Homo sapiens_hsa033200.18942020
141PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18573334
142Regulation of autophagy_Homo sapiens_hsa041400.18155426
143Pancreatic cancer_Homo sapiens_hsa052120.18137233
144Protein digestion and absorption_Homo sapiens_hsa049740.17656814
145Bile secretion_Homo sapiens_hsa049760.17268531
146Glycerolipid metabolism_Homo sapiens_hsa005610.17193964

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