

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 7.61949269 |
| 2 | proteasome assembly (GO:0043248) | 7.26234984 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 6.57464818 |
| 4 | ATP synthesis coupled proton transport (GO:0015986) | 6.57464818 |
| 5 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 6.02219157 |
| 6 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.98127072 |
| 7 | maturation of SSU-rRNA (GO:0030490) | 5.63387065 |
| 8 | respiratory electron transport chain (GO:0022904) | 5.37140976 |
| 9 | electron transport chain (GO:0022900) | 5.23964115 |
| 10 | establishment of integrated proviral latency (GO:0075713) | 5.08758077 |
| 11 | ribosomal large subunit biogenesis (GO:0042273) | 4.84168552 |
| 12 | chaperone-mediated protein transport (GO:0072321) | 4.77093800 |
| 13 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.58069367 |
| 14 | protein complex biogenesis (GO:0070271) | 4.45200458 |
| 15 | viral transcription (GO:0019083) | 4.31321053 |
| 16 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.31143750 |
| 17 | rRNA modification (GO:0000154) | 4.28935755 |
| 18 | protein neddylation (GO:0045116) | 4.27743008 |
| 19 | establishment of viral latency (GO:0019043) | 4.25590694 |
| 20 | pseudouridine synthesis (GO:0001522) | 4.25508732 |
| 21 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.24848106 |
| 22 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.23309850 |
| 23 | translational termination (GO:0006415) | 4.22834012 |
| 24 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.22712885 |
| 25 | oxidative phosphorylation (GO:0006119) | 4.17305183 |
| 26 | negative regulation of ligase activity (GO:0051352) | 4.16520469 |
| 27 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.16520469 |
| 28 | histone mRNA metabolic process (GO:0008334) | 4.16334430 |
| 29 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.12893643 |
| 30 | ribosomal small subunit biogenesis (GO:0042274) | 4.09265248 |
| 31 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 4.09242833 |
| 32 | ribosomal small subunit assembly (GO:0000028) | 4.07966940 |
| 33 | aldehyde catabolic process (GO:0046185) | 4.07288419 |
| 34 | regulation of oxidative phosphorylation (GO:0002082) | 4.07198611 |
| 35 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.05107188 |
| 36 | cotranslational protein targeting to membrane (GO:0006613) | 3.99168415 |
| 37 | DNA damage response, detection of DNA damage (GO:0042769) | 3.97678386 |
| 38 | protein targeting to ER (GO:0045047) | 3.95035787 |
| 39 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.89476905 |
| 40 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.86878022 |
| 41 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.86878022 |
| 42 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.86878022 |
| 43 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.85166487 |
| 44 | NADH dehydrogenase complex assembly (GO:0010257) | 3.85166487 |
| 45 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.85166487 |
| 46 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.83986899 |
| 47 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.82411000 |
| 48 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.82411000 |
| 49 | ATP biosynthetic process (GO:0006754) | 3.77383075 |
| 50 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.76749869 |
| 51 | protein localization to endoplasmic reticulum (GO:0070972) | 3.74491179 |
| 52 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.73871495 |
| 53 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.73871495 |
| 54 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.73239403 |
| 55 | spliceosomal snRNP assembly (GO:0000387) | 3.72090319 |
| 56 | translational elongation (GO:0006414) | 3.71161662 |
| 57 | translation (GO:0006412) | 3.71153457 |
| 58 | regulation of cellular respiration (GO:0043457) | 3.69472126 |
| 59 | positive regulation of ligase activity (GO:0051351) | 3.68061104 |
| 60 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.67479193 |
| 61 | chromatin remodeling at centromere (GO:0031055) | 3.65595571 |
| 62 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.61376337 |
| 63 | protein targeting to mitochondrion (GO:0006626) | 3.57765680 |
| 64 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.57243014 |
| 65 | hydrogen ion transmembrane transport (GO:1902600) | 3.55263372 |
| 66 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.55019916 |
| 67 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.55019916 |
| 68 | rRNA methylation (GO:0031167) | 3.54017284 |
| 69 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.50285038 |
| 70 | CENP-A containing nucleosome assembly (GO:0034080) | 3.49443064 |
| 71 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.47547698 |
| 72 | termination of RNA polymerase III transcription (GO:0006386) | 3.47547698 |
| 73 | maturation of 5.8S rRNA (GO:0000460) | 3.41799886 |
| 74 | respiratory chain complex IV assembly (GO:0008535) | 3.40002930 |
| 75 | protein localization to mitochondrion (GO:0070585) | 3.38260381 |
| 76 | cellular respiration (GO:0045333) | 3.37579455 |
| 77 | translational initiation (GO:0006413) | 3.37346639 |
| 78 | establishment of protein localization to mitochondrion (GO:0072655) | 3.37153363 |
| 79 | platelet dense granule organization (GO:0060155) | 3.34872841 |
| 80 | protein-cofactor linkage (GO:0018065) | 3.27767591 |
| 81 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.27270536 |
| 82 | regulation of ligase activity (GO:0051340) | 3.26848429 |
| 83 | DNA ligation (GO:0006266) | 3.22930771 |
| 84 | cytochrome complex assembly (GO:0017004) | 3.22140030 |
| 85 | rRNA processing (GO:0006364) | 3.20923160 |
| 86 | 7-methylguanosine mRNA capping (GO:0006370) | 3.20733616 |
| 87 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.19192024 |
| 88 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.17776027 |
| 89 | cellular component biogenesis (GO:0044085) | 3.16943417 |
| 90 | mismatch repair (GO:0006298) | 3.14801813 |
| 91 | RNA capping (GO:0036260) | 3.13274219 |
| 92 | 7-methylguanosine RNA capping (GO:0009452) | 3.13274219 |
| 93 | proton transport (GO:0015992) | 3.10685705 |
| 94 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.09230276 |
| 95 | aerobic respiration (GO:0009060) | 3.09082232 |
| 96 | rRNA metabolic process (GO:0016072) | 3.08917358 |
| 97 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.08847349 |
| 98 | transcription from mitochondrial promoter (GO:0006390) | 3.08549080 |
| 99 | cellular protein complex disassembly (GO:0043624) | 3.06905019 |
| 100 | non-recombinational repair (GO:0000726) | 3.06221228 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.67411129 |
| 2 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.81066597 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.64162912 |
| 4 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.80403020 |
| 5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.71725663 |
| 6 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.45945602 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.40588355 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.30163356 |
| 9 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.13108637 |
| 10 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 3.07656299 |
| 11 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.01235917 |
| 12 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.00564303 |
| 13 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.90497233 |
| 14 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.71943871 |
| 15 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.53996842 |
| 16 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.46721355 |
| 17 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.45653387 |
| 18 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.40210145 |
| 19 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.36581794 |
| 20 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.34116646 |
| 21 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.27280840 |
| 22 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.23629981 |
| 23 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.18451221 |
| 24 | MYC_18940864_ChIP-ChIP_HL60_Human | 2.13961606 |
| 25 | VDR_22108803_ChIP-Seq_LS180_Human | 2.09758518 |
| 26 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.04984804 |
| 27 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.04473636 |
| 28 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.02248668 |
| 29 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.01631273 |
| 30 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.98863984 |
| 31 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.92901389 |
| 32 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.91038111 |
| 33 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.84929622 |
| 34 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.84476794 |
| 35 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.83228337 |
| 36 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.80096116 |
| 37 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.77510457 |
| 38 | EWS_26573619_Chip-Seq_HEK293_Human | 1.77189121 |
| 39 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.72569578 |
| 40 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.67557828 |
| 41 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.58376975 |
| 42 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.54976833 |
| 43 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.54030044 |
| 44 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.49269489 |
| 45 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.44864889 |
| 46 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.38196441 |
| 47 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.37928694 |
| 48 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.33588641 |
| 49 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.30695957 |
| 50 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.28007058 |
| 51 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.25728512 |
| 52 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.25162100 |
| 53 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.23968899 |
| 54 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.23860151 |
| 55 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.21713601 |
| 56 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.19932137 |
| 57 | FUS_26573619_Chip-Seq_HEK293_Human | 1.16836336 |
| 58 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.15298277 |
| 59 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.15228340 |
| 60 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.14443010 |
| 61 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.13910984 |
| 62 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.12763975 |
| 63 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.06954060 |
| 64 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.06523129 |
| 65 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.03274192 |
| 66 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.00999914 |
| 67 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.99979620 |
| 68 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.98906021 |
| 69 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.97788103 |
| 70 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.97117697 |
| 71 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.96732789 |
| 72 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.96396807 |
| 73 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.95702122 |
| 74 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.95679047 |
| 75 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.95010308 |
| 76 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.95010308 |
| 77 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.93379000 |
| 78 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92370724 |
| 79 | AR_20517297_ChIP-Seq_VCAP_Human | 0.92368514 |
| 80 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.91100459 |
| 81 | P300_19829295_ChIP-Seq_ESCs_Human | 0.90276611 |
| 82 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.90152440 |
| 83 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.89289218 |
| 84 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.88959200 |
| 85 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.88147595 |
| 86 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.85510207 |
| 87 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.83685512 |
| 88 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.83246557 |
| 89 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.81716651 |
| 90 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.80088282 |
| 91 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.80088282 |
| 92 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.78575014 |
| 93 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.78404340 |
| 94 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.77000239 |
| 95 | NCOR_22424771_ChIP-Seq_293T_Human | 0.75608013 |
| 96 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.74170682 |
| 97 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.73957917 |
| 98 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.73759650 |
| 99 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.73050190 |
| 100 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.71846724 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0006292_abnormal_olfactory_placode | 5.52501819 |
| 2 | MP0003806_abnormal_nucleotide_metabolis | 4.91798984 |
| 3 | MP0008058_abnormal_DNA_repair | 3.89264415 |
| 4 | MP0004147_increased_porphyrin_level | 3.48699473 |
| 5 | MP0003195_calcinosis | 2.92570475 |
| 6 | MP0003950_abnormal_plasma_membrane | 2.89441662 |
| 7 | MP0010094_abnormal_chromosome_stability | 2.80476499 |
| 8 | MP0003136_yellow_coat_color | 2.74009433 |
| 9 | MP0009379_abnormal_foot_pigmentation | 2.73267715 |
| 10 | MP0003693_abnormal_embryo_hatching | 2.49915948 |
| 11 | MP0000372_irregular_coat_pigmentation | 2.41710569 |
| 12 | MP0001529_abnormal_vocalization | 2.41203414 |
| 13 | MP0002102_abnormal_ear_morphology | 2.35645985 |
| 14 | MP0004142_abnormal_muscle_tone | 2.07932554 |
| 15 | MP0010030_abnormal_orbit_morphology | 2.06692674 |
| 16 | MP0005367_renal/urinary_system_phenotyp | 2.04233638 |
| 17 | MP0000516_abnormal_urinary_system | 2.04233638 |
| 18 | MP0002234_abnormal_pharynx_morphology | 2.00893732 |
| 19 | MP0001293_anophthalmia | 1.99267504 |
| 20 | MP0004957_abnormal_blastocyst_morpholog | 1.95768073 |
| 21 | MP0002736_abnormal_nociception_after | 1.86181320 |
| 22 | MP0003878_abnormal_ear_physiology | 1.83992113 |
| 23 | MP0005377_hearing/vestibular/ear_phenot | 1.83992113 |
| 24 | MP0002822_catalepsy | 1.78473005 |
| 25 | MP0002090_abnormal_vision | 1.71597181 |
| 26 | MP0002837_dystrophic_cardiac_calcinosis | 1.70866406 |
| 27 | MP0003315_abnormal_perineum_morphology | 1.69301163 |
| 28 | MP0003186_abnormal_redox_activity | 1.65514581 |
| 29 | MP0006035_abnormal_mitochondrial_morpho | 1.61764074 |
| 30 | MP0006036_abnormal_mitochondrial_physio | 1.61400488 |
| 31 | MP0003718_maternal_effect | 1.56476403 |
| 32 | MP0005084_abnormal_gallbladder_morpholo | 1.55908540 |
| 33 | MP0005551_abnormal_eye_electrophysiolog | 1.49865384 |
| 34 | MP0003111_abnormal_nucleus_morphology | 1.47052444 |
| 35 | MP0002938_white_spotting | 1.44815445 |
| 36 | MP0000537_abnormal_urethra_morphology | 1.40146926 |
| 37 | MP0001485_abnormal_pinna_reflex | 1.37403482 |
| 38 | MP0004145_abnormal_muscle_electrophysio | 1.36204903 |
| 39 | MP0008932_abnormal_embryonic_tissue | 1.34000671 |
| 40 | MP0004885_abnormal_endolymph | 1.26462880 |
| 41 | MP0006054_spinal_hemorrhage | 1.24606111 |
| 42 | MP0005408_hypopigmentation | 1.24152918 |
| 43 | MP0003567_abnormal_fetal_cardiomyocyte | 1.19968057 |
| 44 | MP0005671_abnormal_response_to | 1.19570444 |
| 45 | MP0003938_abnormal_ear_development | 1.12286984 |
| 46 | MP0005075_abnormal_melanosome_morpholog | 1.10717348 |
| 47 | MP0005410_abnormal_fertilization | 1.10351593 |
| 48 | MP0001666_abnormal_nutrient_absorption | 1.09042021 |
| 49 | MP0001968_abnormal_touch/_nociception | 1.07140945 |
| 50 | MP0008789_abnormal_olfactory_epithelium | 1.03655746 |
| 51 | MP0003077_abnormal_cell_cycle | 1.02232973 |
| 52 | MP0006072_abnormal_retinal_apoptosis | 1.00825568 |
| 53 | MP0003283_abnormal_digestive_organ | 0.99983035 |
| 54 | MP0001486_abnormal_startle_reflex | 0.98671795 |
| 55 | MP0000647_abnormal_sebaceous_gland | 0.94690152 |
| 56 | MP0005171_absent_coat_pigmentation | 0.94223559 |
| 57 | MP0000383_abnormal_hair_follicle | 0.93845854 |
| 58 | MP0003786_premature_aging | 0.92851508 |
| 59 | MP0001286_abnormal_eye_development | 0.92829450 |
| 60 | MP0009333_abnormal_splenocyte_physiolog | 0.90379239 |
| 61 | MP0001905_abnormal_dopamine_level | 0.89132576 |
| 62 | MP0002277_abnormal_respiratory_mucosa | 0.88820309 |
| 63 | MP0003119_abnormal_digestive_system | 0.87520672 |
| 64 | MP0002160_abnormal_reproductive_system | 0.86421325 |
| 65 | MP0002751_abnormal_autonomic_nervous | 0.83279718 |
| 66 | MP0005253_abnormal_eye_physiology | 0.82565766 |
| 67 | MP0005379_endocrine/exocrine_gland_phen | 0.82553767 |
| 68 | MP0008872_abnormal_physiological_respon | 0.79308468 |
| 69 | MP0001929_abnormal_gametogenesis | 0.79209797 |
| 70 | MP0004043_abnormal_pH_regulation | 0.78549290 |
| 71 | MP0002095_abnormal_skin_pigmentation | 0.77873700 |
| 72 | MP0000762_abnormal_tongue_morphology | 0.77530901 |
| 73 | MP0002282_abnormal_trachea_morphology | 0.77249667 |
| 74 | MP0004133_heterotaxia | 0.76195188 |
| 75 | MP0001440_abnormal_grooming_behavior | 0.73124186 |
| 76 | MP0000427_abnormal_hair_cycle | 0.71619609 |
| 77 | MP0002638_abnormal_pupillary_reflex | 0.70513300 |
| 78 | MP0005332_abnormal_amino_acid | 0.67840712 |
| 79 | MP0002272_abnormal_nervous_system | 0.67709686 |
| 80 | MP0001324_abnormal_eye_pigmentation | 0.67109191 |
| 81 | MP0001764_abnormal_homeostasis | 0.66759489 |
| 82 | MP0001145_abnormal_male_reproductive | 0.66645655 |
| 83 | MP0001984_abnormal_olfaction | 0.65295956 |
| 84 | MP0005645_abnormal_hypothalamus_physiol | 0.65190863 |
| 85 | MP0000358_abnormal_cell_content/ | 0.63653981 |
| 86 | MP0002210_abnormal_sex_determination | 0.63234875 |
| 87 | MP0005195_abnormal_posterior_eye | 0.62119422 |
| 88 | MP0000026_abnormal_inner_ear | 0.61411704 |
| 89 | MP0005636_abnormal_mineral_homeostasis | 0.60506972 |
| 90 | MP0009053_abnormal_anal_canal | 0.59600575 |
| 91 | MP0002396_abnormal_hematopoietic_system | 0.59205238 |
| 92 | MP0005391_vision/eye_phenotype | 0.59011676 |
| 93 | MP0003698_abnormal_male_reproductive | 0.58154136 |
| 94 | MP0005167_abnormal_blood-brain_barrier | 0.57719576 |
| 95 | MP0010678_abnormal_skin_adnexa | 0.57331883 |
| 96 | MP0000371_diluted_coat_color | 0.57326267 |
| 97 | MP0004381_abnormal_hair_follicle | 0.56553035 |
| 98 | MP0001346_abnormal_lacrimal_gland | 0.56506128 |
| 99 | MP0000653_abnormal_sex_gland | 0.56164806 |
| 100 | MP0001661_extended_life_span | 0.55969933 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.83495259 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.49999351 |
| 3 | Hepatocellular necrosis (HP:0001404) | 5.06405499 |
| 4 | Mitochondrial inheritance (HP:0001427) | 5.04095797 |
| 5 | Progressive macrocephaly (HP:0004481) | 5.00995400 |
| 6 | Acute encephalopathy (HP:0006846) | 4.84761013 |
| 7 | Increased CSF lactate (HP:0002490) | 4.45665071 |
| 8 | 3-Methylglutaconic aciduria (HP:0003535) | 4.43534858 |
| 9 | Hepatic necrosis (HP:0002605) | 4.27341072 |
| 10 | Increased hepatocellular lipid droplets (HP:0006565) | 4.02450500 |
| 11 | Lipid accumulation in hepatocytes (HP:0006561) | 3.97927295 |
| 12 | Cerebral edema (HP:0002181) | 3.76213462 |
| 13 | Congenital, generalized hypertrichosis (HP:0004540) | 3.75542968 |
| 14 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.65755169 |
| 15 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.56254825 |
| 16 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.53477353 |
| 17 | Renal Fanconi syndrome (HP:0001994) | 3.46550497 |
| 18 | Increased serum lactate (HP:0002151) | 3.45294298 |
| 19 | Large for gestational age (HP:0001520) | 3.36950725 |
| 20 | Oral leukoplakia (HP:0002745) | 3.36703122 |
| 21 | Abnormality of methionine metabolism (HP:0010901) | 3.35854832 |
| 22 | Leukodystrophy (HP:0002415) | 3.25957689 |
| 23 | Increased intramyocellular lipid droplets (HP:0012240) | 3.24340608 |
| 24 | Hypothermia (HP:0002045) | 3.19089366 |
| 25 | Reticulocytopenia (HP:0001896) | 3.13117402 |
| 26 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.02261002 |
| 27 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.02261002 |
| 28 | Exercise intolerance (HP:0003546) | 3.00934054 |
| 29 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.99400629 |
| 30 | Septo-optic dysplasia (HP:0100842) | 2.93829160 |
| 31 | Reduced antithrombin III activity (HP:0001976) | 2.92881076 |
| 32 | Absent septum pellucidum (HP:0001331) | 2.92560465 |
| 33 | Increased muscle lipid content (HP:0009058) | 2.88527158 |
| 34 | Abnormality of the labia minora (HP:0012880) | 2.87450233 |
| 35 | Exertional dyspnea (HP:0002875) | 2.85428811 |
| 36 | Respiratory failure (HP:0002878) | 2.75538731 |
| 37 | Lactic acidosis (HP:0003128) | 2.73684419 |
| 38 | Macrocytic anemia (HP:0001972) | 2.73156677 |
| 39 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.72748647 |
| 40 | Abnormality of the septum pellucidum (HP:0007375) | 2.67818865 |
| 41 | Type I transferrin isoform profile (HP:0003642) | 2.65006369 |
| 42 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.63030806 |
| 43 | Maternal diabetes (HP:0009800) | 2.61813361 |
| 44 | Birth length less than 3rd percentile (HP:0003561) | 2.55069077 |
| 45 | Abnormality of the pons (HP:0007361) | 2.54650404 |
| 46 | Optic disc pallor (HP:0000543) | 2.39256563 |
| 47 | Abnormality of homocysteine metabolism (HP:0010919) | 2.35655815 |
| 48 | Homocystinuria (HP:0002156) | 2.35655815 |
| 49 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.32975419 |
| 50 | Duplicated collecting system (HP:0000081) | 2.31072862 |
| 51 | Lethargy (HP:0001254) | 2.30782702 |
| 52 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.28646993 |
| 53 | Rough bone trabeculation (HP:0100670) | 2.28394737 |
| 54 | Submucous cleft hard palate (HP:0000176) | 2.26855752 |
| 55 | Adrenal hypoplasia (HP:0000835) | 2.19751939 |
| 56 | Colon cancer (HP:0003003) | 2.16120681 |
| 57 | CNS demyelination (HP:0007305) | 2.15486213 |
| 58 | Testicular atrophy (HP:0000029) | 2.15252590 |
| 59 | Hypoglycemic seizures (HP:0002173) | 2.14613547 |
| 60 | Megaloblastic anemia (HP:0001889) | 2.10091483 |
| 61 | Abnormality of renal resorption (HP:0011038) | 2.09758366 |
| 62 | Abnormality of the nasal septum (HP:0000419) | 2.08985733 |
| 63 | Abnormality of the renal collecting system (HP:0004742) | 2.08002715 |
| 64 | Hyperphosphaturia (HP:0003109) | 2.07781248 |
| 65 | Respiratory difficulties (HP:0002880) | 2.04347216 |
| 66 | Microvesicular hepatic steatosis (HP:0001414) | 2.04004031 |
| 67 | Degeneration of anterior horn cells (HP:0002398) | 2.03317669 |
| 68 | Abnormality of the anterior horn cell (HP:0006802) | 2.03317669 |
| 69 | Porencephaly (HP:0002132) | 2.00176242 |
| 70 | Horseshoe kidney (HP:0000085) | 1.99829998 |
| 71 | Parakeratosis (HP:0001036) | 1.98997802 |
| 72 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.96345178 |
| 73 | Anosmia (HP:0000458) | 1.90177132 |
| 74 | Hypomagnesemia (HP:0002917) | 1.85595626 |
| 75 | Congenital ichthyosiform erythroderma (HP:0007431) | 1.85120357 |
| 76 | Abnormal number of erythroid precursors (HP:0012131) | 1.84544439 |
| 77 | Dry hair (HP:0011359) | 1.82408682 |
| 78 | Meckel diverticulum (HP:0002245) | 1.82134765 |
| 79 | Sparse eyelashes (HP:0000653) | 1.81361034 |
| 80 | Cellular immunodeficiency (HP:0005374) | 1.80760255 |
| 81 | Stenosis of the external auditory canal (HP:0000402) | 1.80551077 |
| 82 | Emotional lability (HP:0000712) | 1.80427513 |
| 83 | Median cleft lip (HP:0000161) | 1.80280995 |
| 84 | Abnormal lung lobation (HP:0002101) | 1.79914450 |
| 85 | Aplastic anemia (HP:0001915) | 1.79145626 |
| 86 | Pancytopenia (HP:0001876) | 1.78148821 |
| 87 | Esophageal atresia (HP:0002032) | 1.76962130 |
| 88 | Abnormality of the preputium (HP:0100587) | 1.75734315 |
| 89 | Aqueductal stenosis (HP:0002410) | 1.75167707 |
| 90 | Amniotic constriction ring (HP:0009775) | 1.73552666 |
| 91 | Abnormality of placental membranes (HP:0011409) | 1.73552666 |
| 92 | Cleft eyelid (HP:0000625) | 1.73445507 |
| 93 | Pallor (HP:0000980) | 1.73289672 |
| 94 | Abnormality of the ileum (HP:0001549) | 1.71145993 |
| 95 | Anophthalmia (HP:0000528) | 1.68658137 |
| 96 | Abnormality of midbrain morphology (HP:0002418) | 1.67974904 |
| 97 | Molar tooth sign on MRI (HP:0002419) | 1.67974904 |
| 98 | Methylmalonic acidemia (HP:0002912) | 1.67605151 |
| 99 | Polydipsia (HP:0001959) | 1.66503354 |
| 100 | Abnormal drinking behavior (HP:0030082) | 1.66503354 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.76280759 |
| 2 | EIF2AK1 | 3.94508898 |
| 3 | MST4 | 3.65422572 |
| 4 | STK16 | 3.45789158 |
| 5 | TSSK6 | 3.05539811 |
| 6 | TRIM28 | 2.99649077 |
| 7 | EIF2AK3 | 2.84080711 |
| 8 | TAF1 | 2.73483417 |
| 9 | BUB1 | 2.62159838 |
| 10 | ZAK | 2.45266005 |
| 11 | VRK1 | 2.28857745 |
| 12 | PLK3 | 2.26146043 |
| 13 | NEK1 | 2.13181348 |
| 14 | PBK | 2.12177415 |
| 15 | NUAK1 | 2.08027308 |
| 16 | CCNB1 | 1.99640303 |
| 17 | SRPK1 | 1.89143150 |
| 18 | MARK3 | 1.84202927 |
| 19 | BRSK2 | 1.67992977 |
| 20 | TIE1 | 1.66786211 |
| 21 | WEE1 | 1.58291970 |
| 22 | CDC7 | 1.53020716 |
| 23 | NME1 | 1.45648652 |
| 24 | STK4 | 1.43148361 |
| 25 | TEC | 1.42594153 |
| 26 | EPHA4 | 1.39814043 |
| 27 | EPHB2 | 1.32549426 |
| 28 | STK39 | 1.27272148 |
| 29 | EIF2AK2 | 1.15769722 |
| 30 | BMPR1B | 1.14356022 |
| 31 | ACVR1B | 1.10567914 |
| 32 | TTK | 1.07478882 |
| 33 | DAPK3 | 1.04974352 |
| 34 | PDK2 | 1.04129737 |
| 35 | FGR | 1.01916295 |
| 36 | WNK3 | 1.01825747 |
| 37 | FGFR1 | 0.98490072 |
| 38 | STK38L | 0.96030244 |
| 39 | BRSK1 | 0.94731392 |
| 40 | MAP3K12 | 0.93559590 |
| 41 | DAPK1 | 0.93309268 |
| 42 | NME2 | 0.93222580 |
| 43 | BMPR2 | 0.90837333 |
| 44 | DYRK2 | 0.90061063 |
| 45 | WNK4 | 0.88796204 |
| 46 | PLK2 | 0.81710200 |
| 47 | ILK | 0.81633472 |
| 48 | MYLK | 0.81494163 |
| 49 | ATR | 0.77284714 |
| 50 | CSNK1G1 | 0.76228749 |
| 51 | AURKB | 0.76149662 |
| 52 | FRK | 0.73810426 |
| 53 | ADRBK2 | 0.73182466 |
| 54 | DMPK | 0.72219735 |
| 55 | TAOK3 | 0.71949632 |
| 56 | PLK1 | 0.70796553 |
| 57 | PLK4 | 0.66079097 |
| 58 | GRK1 | 0.65344335 |
| 59 | PAK4 | 0.61665408 |
| 60 | PASK | 0.60771630 |
| 61 | CSNK1G3 | 0.60073431 |
| 62 | TLK1 | 0.57908890 |
| 63 | ALK | 0.57696033 |
| 64 | ADRBK1 | 0.57376443 |
| 65 | OXSR1 | 0.54411813 |
| 66 | MKNK2 | 0.53063827 |
| 67 | RPS6KB2 | 0.52786368 |
| 68 | PKN1 | 0.50600440 |
| 69 | CSNK2A2 | 0.50587868 |
| 70 | MKNK1 | 0.49666964 |
| 71 | TXK | 0.48910951 |
| 72 | PRKCG | 0.48080528 |
| 73 | CHEK2 | 0.47609130 |
| 74 | STK24 | 0.45268029 |
| 75 | INSRR | 0.44781168 |
| 76 | CSNK2A1 | 0.43849807 |
| 77 | ITK | 0.42754728 |
| 78 | MAP3K9 | 0.42702194 |
| 79 | TGFBR1 | 0.42666171 |
| 80 | STK3 | 0.40867615 |
| 81 | CSNK1E | 0.40178160 |
| 82 | MAP2K6 | 0.39806483 |
| 83 | CSNK1G2 | 0.39699822 |
| 84 | MATK | 0.39697869 |
| 85 | NLK | 0.38550989 |
| 86 | CSNK1A1L | 0.37545685 |
| 87 | MELK | 0.36633969 |
| 88 | CDK7 | 0.36537324 |
| 89 | TNIK | 0.36347704 |
| 90 | MAPK13 | 0.33681556 |
| 91 | FGFR2 | 0.29801746 |
| 92 | MAP4K2 | 0.29731944 |
| 93 | MINK1 | 0.29475299 |
| 94 | IKBKB | 0.29106968 |
| 95 | PRKDC | 0.28796123 |
| 96 | GRK5 | 0.28126233 |
| 97 | ATM | 0.27825496 |
| 98 | KDR | 0.26484492 |
| 99 | CHEK1 | 0.25801824 |
| 100 | MAPKAPK3 | 0.25643795 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.10061032 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.73633784 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 4.14966769 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.88380976 |
| 5 | Huntingtons disease_Homo sapiens_hsa05016 | 2.75670995 |
| 6 | Protein export_Homo sapiens_hsa03060 | 2.72855413 |
| 7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.64833217 |
| 8 | Alzheimers disease_Homo sapiens_hsa05010 | 2.57504591 |
| 9 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.56584187 |
| 10 | DNA replication_Homo sapiens_hsa03030 | 2.36159355 |
| 11 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.24068150 |
| 12 | RNA polymerase_Homo sapiens_hsa03020 | 2.17900810 |
| 13 | Mismatch repair_Homo sapiens_hsa03430 | 2.15953715 |
| 14 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.02924481 |
| 15 | Spliceosome_Homo sapiens_hsa03040 | 1.93323072 |
| 16 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.87749883 |
| 17 | Homologous recombination_Homo sapiens_hsa03440 | 1.81461296 |
| 18 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.72553474 |
| 19 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.64044340 |
| 20 | Basal transcription factors_Homo sapiens_hsa03022 | 1.50973457 |
| 21 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.49047390 |
| 22 | RNA degradation_Homo sapiens_hsa03018 | 1.48937716 |
| 23 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.36340121 |
| 24 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.35522044 |
| 25 | RNA transport_Homo sapiens_hsa03013 | 1.34628458 |
| 26 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.33777976 |
| 27 | Base excision repair_Homo sapiens_hsa03410 | 1.26256648 |
| 28 | Asthma_Homo sapiens_hsa05310 | 1.20646549 |
| 29 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.20406541 |
| 30 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.14911272 |
| 31 | Purine metabolism_Homo sapiens_hsa00230 | 1.13242107 |
| 32 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.07936576 |
| 33 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.07508950 |
| 34 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.07222246 |
| 35 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.05277508 |
| 36 | Cell cycle_Homo sapiens_hsa04110 | 1.00444853 |
| 37 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.99341756 |
| 38 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.97160791 |
| 39 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.96625064 |
| 40 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.96008873 |
| 41 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.89391685 |
| 42 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.87322613 |
| 43 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.86886265 |
| 44 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.86037612 |
| 45 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.78785282 |
| 46 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.78245971 |
| 47 | Allograft rejection_Homo sapiens_hsa05330 | 0.78116976 |
| 48 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.77563103 |
| 49 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.77181280 |
| 50 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.76986676 |
| 51 | Metabolic pathways_Homo sapiens_hsa01100 | 0.75649803 |
| 52 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.72546076 |
| 53 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.71505250 |
| 54 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.70924309 |
| 55 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.68862489 |
| 56 | Phototransduction_Homo sapiens_hsa04744 | 0.63493289 |
| 57 | Sulfur relay system_Homo sapiens_hsa04122 | 0.63028912 |
| 58 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.61028077 |
| 59 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.58300680 |
| 60 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.58187398 |
| 61 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.57984794 |
| 62 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.57513613 |
| 63 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.54091109 |
| 64 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.53992516 |
| 65 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.53832543 |
| 66 | Carbon metabolism_Homo sapiens_hsa01200 | 0.52050541 |
| 67 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.49491477 |
| 68 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.48982460 |
| 69 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.48298378 |
| 70 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.47778085 |
| 71 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.47152324 |
| 72 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.45595504 |
| 73 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.44640004 |
| 74 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.43498429 |
| 75 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.43191832 |
| 76 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.42684133 |
| 77 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.42057872 |
| 78 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.41183425 |
| 79 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.39031401 |
| 80 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.37499651 |
| 81 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.36940402 |
| 82 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.36768663 |
| 83 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.35675265 |
| 84 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.34465108 |
| 85 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.33423664 |
| 86 | Peroxisome_Homo sapiens_hsa04146 | 0.33304674 |
| 87 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.33229514 |
| 88 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.33032553 |
| 89 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.30785320 |
| 90 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.29708122 |
| 91 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.29107353 |
| 92 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.28467910 |
| 93 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.27718613 |
| 94 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.27546053 |
| 95 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.26514298 |
| 96 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.25646671 |
| 97 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.25632412 |
| 98 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.23445098 |
| 99 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.22571539 |
| 100 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.22130161 |

