PHBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.61949269
2proteasome assembly (GO:0043248)7.26234984
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.57464818
4ATP synthesis coupled proton transport (GO:0015986)6.57464818
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.02219157
6establishment of protein localization to mitochondrial membrane (GO:0090151)5.98127072
7maturation of SSU-rRNA (GO:0030490)5.63387065
8respiratory electron transport chain (GO:0022904)5.37140976
9electron transport chain (GO:0022900)5.23964115
10establishment of integrated proviral latency (GO:0075713)5.08758077
11ribosomal large subunit biogenesis (GO:0042273)4.84168552
12chaperone-mediated protein transport (GO:0072321)4.77093800
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.58069367
14protein complex biogenesis (GO:0070271)4.45200458
15viral transcription (GO:0019083)4.31321053
16positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.31143750
17rRNA modification (GO:0000154)4.28935755
18protein neddylation (GO:0045116)4.27743008
19establishment of viral latency (GO:0019043)4.25590694
20pseudouridine synthesis (GO:0001522)4.25508732
21regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.24848106
22mitochondrial respiratory chain complex assembly (GO:0033108)4.23309850
23translational termination (GO:0006415)4.22834012
24water-soluble vitamin biosynthetic process (GO:0042364)4.22712885
25oxidative phosphorylation (GO:0006119)4.17305183
26negative regulation of ligase activity (GO:0051352)4.16520469
27negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.16520469
28histone mRNA metabolic process (GO:0008334)4.16334430
29regulation of cellular amino acid metabolic process (GO:0006521)4.12893643
30ribosomal small subunit biogenesis (GO:0042274)4.09265248
31anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.09242833
32ribosomal small subunit assembly (GO:0000028)4.07966940
33aldehyde catabolic process (GO:0046185)4.07288419
34regulation of oxidative phosphorylation (GO:0002082)4.07198611
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.05107188
36cotranslational protein targeting to membrane (GO:0006613)3.99168415
37DNA damage response, detection of DNA damage (GO:0042769)3.97678386
38protein targeting to ER (GO:0045047)3.95035787
39DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.89476905
40signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.86878022
41signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.86878022
42signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.86878022
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.85166487
44NADH dehydrogenase complex assembly (GO:0010257)3.85166487
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.85166487
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.83986899
47intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.82411000
48signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.82411000
49ATP biosynthetic process (GO:0006754)3.77383075
50nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.76749869
51protein localization to endoplasmic reticulum (GO:0070972)3.74491179
52signal transduction involved in DNA integrity checkpoint (GO:0072401)3.73871495
53signal transduction involved in DNA damage checkpoint (GO:0072422)3.73871495
54establishment of protein localization to endoplasmic reticulum (GO:0072599)3.73239403
55spliceosomal snRNP assembly (GO:0000387)3.72090319
56translational elongation (GO:0006414)3.71161662
57translation (GO:0006412)3.71153457
58regulation of cellular respiration (GO:0043457)3.69472126
59positive regulation of ligase activity (GO:0051351)3.68061104
60signal transduction involved in cell cycle checkpoint (GO:0072395)3.67479193
61chromatin remodeling at centromere (GO:0031055)3.65595571
62positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.61376337
63protein targeting to mitochondrion (GO:0006626)3.57765680
64purine nucleoside triphosphate biosynthetic process (GO:0009145)3.57243014
65hydrogen ion transmembrane transport (GO:1902600)3.55263372
66regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.55019916
67regulation of mitotic spindle checkpoint (GO:1903504)3.55019916
68rRNA methylation (GO:0031167)3.54017284
69purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.50285038
70CENP-A containing nucleosome assembly (GO:0034080)3.49443064
71transcription elongation from RNA polymerase III promoter (GO:0006385)3.47547698
72termination of RNA polymerase III transcription (GO:0006386)3.47547698
73maturation of 5.8S rRNA (GO:0000460)3.41799886
74respiratory chain complex IV assembly (GO:0008535)3.40002930
75protein localization to mitochondrion (GO:0070585)3.38260381
76cellular respiration (GO:0045333)3.37579455
77translational initiation (GO:0006413)3.37346639
78establishment of protein localization to mitochondrion (GO:0072655)3.37153363
79platelet dense granule organization (GO:0060155)3.34872841
80protein-cofactor linkage (GO:0018065)3.27767591
81telomere maintenance via semi-conservative replication (GO:0032201)3.27270536
82regulation of ligase activity (GO:0051340)3.26848429
83DNA ligation (GO:0006266)3.22930771
84cytochrome complex assembly (GO:0017004)3.22140030
85rRNA processing (GO:0006364)3.20923160
867-methylguanosine mRNA capping (GO:0006370)3.20733616
87regulation of ubiquitin-protein transferase activity (GO:0051438)3.19192024
88antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.17776027
89cellular component biogenesis (GO:0044085)3.16943417
90mismatch repair (GO:0006298)3.14801813
91RNA capping (GO:0036260)3.13274219
927-methylguanosine RNA capping (GO:0009452)3.13274219
93proton transport (GO:0015992)3.10685705
94ribonucleoside triphosphate biosynthetic process (GO:0009201)3.09230276
95aerobic respiration (GO:0009060)3.09082232
96rRNA metabolic process (GO:0016072)3.08917358
97nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.08847349
98transcription from mitochondrial promoter (GO:0006390)3.08549080
99cellular protein complex disassembly (GO:0043624)3.06905019
100non-recombinational repair (GO:0000726)3.06221228

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.67411129
2EST1_17652178_ChIP-ChIP_JURKAT_Human4.81066597
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.64162912
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.80403020
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.71725663
6CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.45945602
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.40588355
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.30163356
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.13108637
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.07656299
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01235917
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.00564303
13E2F7_22180533_ChIP-Seq_HELA_Human2.90497233
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71943871
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53996842
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46721355
17VDR_23849224_ChIP-Seq_CD4+_Human2.45653387
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.40210145
19ELK1_19687146_ChIP-ChIP_HELA_Human2.36581794
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34116646
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27280840
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.23629981
23FOXP3_21729870_ChIP-Seq_TREG_Human2.18451221
24MYC_18940864_ChIP-ChIP_HL60_Human2.13961606
25VDR_22108803_ChIP-Seq_LS180_Human2.09758518
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.04984804
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04473636
28DCP1A_22483619_ChIP-Seq_HELA_Human2.02248668
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.01631273
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.98863984
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.92901389
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91038111
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.84929622
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84476794
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83228337
36TTF2_22483619_ChIP-Seq_HELA_Human1.80096116
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.77510457
38EWS_26573619_Chip-Seq_HEK293_Human1.77189121
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72569578
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67557828
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58376975
42XRN2_22483619_ChIP-Seq_HELA_Human1.54976833
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.54030044
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49269489
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44864889
46GABP_19822575_ChIP-Seq_HepG2_Human1.38196441
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37928694
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33588641
49IRF1_19129219_ChIP-ChIP_H3396_Human1.30695957
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.28007058
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25728512
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25162100
53ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23968899
54ZNF274_21170338_ChIP-Seq_K562_Hela1.23860151
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21713601
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19932137
57FUS_26573619_Chip-Seq_HEK293_Human1.16836336
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15298277
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15228340
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14443010
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13910984
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12763975
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06954060
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.06523129
65CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03274192
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00999914
67NFE2_27457419_Chip-Seq_LIVER_Mouse0.99979620
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98906021
69E2F1_21310950_ChIP-Seq_MCF-7_Human0.97788103
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97117697
71CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96732789
72ERG_20517297_ChIP-Seq_VCAP_Human0.96396807
73TP53_22573176_ChIP-Seq_HFKS_Human0.95702122
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95679047
75SOX2_19829295_ChIP-Seq_ESCs_Human0.95010308
76NANOG_19829295_ChIP-Seq_ESCs_Human0.95010308
77AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93379000
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92370724
79AR_20517297_ChIP-Seq_VCAP_Human0.92368514
80KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91100459
81P300_19829295_ChIP-Seq_ESCs_Human0.90276611
82SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90152440
83SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89289218
84NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88959200
85PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88147595
86EZH2_27294783_Chip-Seq_NPCs_Mouse0.85510207
87PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83685512
88SOX17_20123909_ChIP-Seq_XEN_Mouse0.83246557
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81716651
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.80088282
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80088282
92IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.78575014
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.78404340
94MYC_19829295_ChIP-Seq_ESCs_Human0.77000239
95NCOR_22424771_ChIP-Seq_293T_Human0.75608013
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.74170682
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.73957917
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73759650
99CTBP2_25329375_ChIP-Seq_LNCAP_Human0.73050190
100CTCF_18555785_ChIP-Seq_MESCs_Mouse0.71846724

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.52501819
2MP0003806_abnormal_nucleotide_metabolis4.91798984
3MP0008058_abnormal_DNA_repair3.89264415
4MP0004147_increased_porphyrin_level3.48699473
5MP0003195_calcinosis2.92570475
6MP0003950_abnormal_plasma_membrane2.89441662
7MP0010094_abnormal_chromosome_stability2.80476499
8MP0003136_yellow_coat_color2.74009433
9MP0009379_abnormal_foot_pigmentation2.73267715
10MP0003693_abnormal_embryo_hatching2.49915948
11MP0000372_irregular_coat_pigmentation2.41710569
12MP0001529_abnormal_vocalization2.41203414
13MP0002102_abnormal_ear_morphology2.35645985
14MP0004142_abnormal_muscle_tone2.07932554
15MP0010030_abnormal_orbit_morphology2.06692674
16MP0005367_renal/urinary_system_phenotyp2.04233638
17MP0000516_abnormal_urinary_system2.04233638
18MP0002234_abnormal_pharynx_morphology2.00893732
19MP0001293_anophthalmia1.99267504
20MP0004957_abnormal_blastocyst_morpholog1.95768073
21MP0002736_abnormal_nociception_after1.86181320
22MP0003878_abnormal_ear_physiology1.83992113
23MP0005377_hearing/vestibular/ear_phenot1.83992113
24MP0002822_catalepsy1.78473005
25MP0002090_abnormal_vision1.71597181
26MP0002837_dystrophic_cardiac_calcinosis1.70866406
27MP0003315_abnormal_perineum_morphology1.69301163
28MP0003186_abnormal_redox_activity1.65514581
29MP0006035_abnormal_mitochondrial_morpho1.61764074
30MP0006036_abnormal_mitochondrial_physio1.61400488
31MP0003718_maternal_effect1.56476403
32MP0005084_abnormal_gallbladder_morpholo1.55908540
33MP0005551_abnormal_eye_electrophysiolog1.49865384
34MP0003111_abnormal_nucleus_morphology1.47052444
35MP0002938_white_spotting1.44815445
36MP0000537_abnormal_urethra_morphology1.40146926
37MP0001485_abnormal_pinna_reflex1.37403482
38MP0004145_abnormal_muscle_electrophysio1.36204903
39MP0008932_abnormal_embryonic_tissue1.34000671
40MP0004885_abnormal_endolymph1.26462880
41MP0006054_spinal_hemorrhage1.24606111
42MP0005408_hypopigmentation1.24152918
43MP0003567_abnormal_fetal_cardiomyocyte1.19968057
44MP0005671_abnormal_response_to1.19570444
45MP0003938_abnormal_ear_development1.12286984
46MP0005075_abnormal_melanosome_morpholog1.10717348
47MP0005410_abnormal_fertilization1.10351593
48MP0001666_abnormal_nutrient_absorption1.09042021
49MP0001968_abnormal_touch/_nociception1.07140945
50MP0008789_abnormal_olfactory_epithelium1.03655746
51MP0003077_abnormal_cell_cycle1.02232973
52MP0006072_abnormal_retinal_apoptosis1.00825568
53MP0003283_abnormal_digestive_organ0.99983035
54MP0001486_abnormal_startle_reflex0.98671795
55MP0000647_abnormal_sebaceous_gland0.94690152
56MP0005171_absent_coat_pigmentation0.94223559
57MP0000383_abnormal_hair_follicle0.93845854
58MP0003786_premature_aging0.92851508
59MP0001286_abnormal_eye_development0.92829450
60MP0009333_abnormal_splenocyte_physiolog0.90379239
61MP0001905_abnormal_dopamine_level0.89132576
62MP0002277_abnormal_respiratory_mucosa0.88820309
63MP0003119_abnormal_digestive_system0.87520672
64MP0002160_abnormal_reproductive_system0.86421325
65MP0002751_abnormal_autonomic_nervous0.83279718
66MP0005253_abnormal_eye_physiology0.82565766
67MP0005379_endocrine/exocrine_gland_phen0.82553767
68MP0008872_abnormal_physiological_respon0.79308468
69MP0001929_abnormal_gametogenesis0.79209797
70MP0004043_abnormal_pH_regulation0.78549290
71MP0002095_abnormal_skin_pigmentation0.77873700
72MP0000762_abnormal_tongue_morphology0.77530901
73MP0002282_abnormal_trachea_morphology0.77249667
74MP0004133_heterotaxia0.76195188
75MP0001440_abnormal_grooming_behavior0.73124186
76MP0000427_abnormal_hair_cycle0.71619609
77MP0002638_abnormal_pupillary_reflex0.70513300
78MP0005332_abnormal_amino_acid0.67840712
79MP0002272_abnormal_nervous_system0.67709686
80MP0001324_abnormal_eye_pigmentation0.67109191
81MP0001764_abnormal_homeostasis0.66759489
82MP0001145_abnormal_male_reproductive0.66645655
83MP0001984_abnormal_olfaction0.65295956
84MP0005645_abnormal_hypothalamus_physiol0.65190863
85MP0000358_abnormal_cell_content/0.63653981
86MP0002210_abnormal_sex_determination0.63234875
87MP0005195_abnormal_posterior_eye0.62119422
88MP0000026_abnormal_inner_ear0.61411704
89MP0005636_abnormal_mineral_homeostasis0.60506972
90MP0009053_abnormal_anal_canal0.59600575
91MP0002396_abnormal_hematopoietic_system0.59205238
92MP0005391_vision/eye_phenotype0.59011676
93MP0003698_abnormal_male_reproductive0.58154136
94MP0005167_abnormal_blood-brain_barrier0.57719576
95MP0010678_abnormal_skin_adnexa0.57331883
96MP0000371_diluted_coat_color0.57326267
97MP0004381_abnormal_hair_follicle0.56553035
98MP0001346_abnormal_lacrimal_gland0.56506128
99MP0000653_abnormal_sex_gland0.56164806
100MP0001661_extended_life_span0.55969933

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.83495259
2Abnormal mitochondria in muscle tissue (HP:0008316)5.49999351
3Hepatocellular necrosis (HP:0001404)5.06405499
4Mitochondrial inheritance (HP:0001427)5.04095797
5Progressive macrocephaly (HP:0004481)5.00995400
6Acute encephalopathy (HP:0006846)4.84761013
7Increased CSF lactate (HP:0002490)4.45665071
83-Methylglutaconic aciduria (HP:0003535)4.43534858
9Hepatic necrosis (HP:0002605)4.27341072
10Increased hepatocellular lipid droplets (HP:0006565)4.02450500
11Lipid accumulation in hepatocytes (HP:0006561)3.97927295
12Cerebral edema (HP:0002181)3.76213462
13Congenital, generalized hypertrichosis (HP:0004540)3.75542968
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.65755169
15Aplasia/Hypoplasia of the sacrum (HP:0008517)3.56254825
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.53477353
17Renal Fanconi syndrome (HP:0001994)3.46550497
18Increased serum lactate (HP:0002151)3.45294298
19Large for gestational age (HP:0001520)3.36950725
20Oral leukoplakia (HP:0002745)3.36703122
21Abnormality of methionine metabolism (HP:0010901)3.35854832
22Leukodystrophy (HP:0002415)3.25957689
23Increased intramyocellular lipid droplets (HP:0012240)3.24340608
24Hypothermia (HP:0002045)3.19089366
25Reticulocytopenia (HP:0001896)3.13117402
26Decreased activity of mitochondrial respiratory chain (HP:0008972)3.02261002
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.02261002
28Exercise intolerance (HP:0003546)3.00934054
29Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.99400629
30Septo-optic dysplasia (HP:0100842)2.93829160
31Reduced antithrombin III activity (HP:0001976)2.92881076
32Absent septum pellucidum (HP:0001331)2.92560465
33Increased muscle lipid content (HP:0009058)2.88527158
34Abnormality of the labia minora (HP:0012880)2.87450233
35Exertional dyspnea (HP:0002875)2.85428811
36Respiratory failure (HP:0002878)2.75538731
37Lactic acidosis (HP:0003128)2.73684419
38Macrocytic anemia (HP:0001972)2.73156677
39Abnormality of aspartate family amino acid metabolism (HP:0010899)2.72748647
40Abnormality of the septum pellucidum (HP:0007375)2.67818865
41Type I transferrin isoform profile (HP:0003642)2.65006369
42Hyperinsulinemic hypoglycemia (HP:0000825)2.63030806
43Maternal diabetes (HP:0009800)2.61813361
44Birth length less than 3rd percentile (HP:0003561)2.55069077
45Abnormality of the pons (HP:0007361)2.54650404
46Optic disc pallor (HP:0000543)2.39256563
47Abnormality of homocysteine metabolism (HP:0010919)2.35655815
48Homocystinuria (HP:0002156)2.35655815
49Pancreatic islet-cell hyperplasia (HP:0004510)2.32975419
50Duplicated collecting system (HP:0000081)2.31072862
51Lethargy (HP:0001254)2.30782702
52Abnormality of sulfur amino acid metabolism (HP:0004339)2.28646993
53Rough bone trabeculation (HP:0100670)2.28394737
54Submucous cleft hard palate (HP:0000176)2.26855752
55Adrenal hypoplasia (HP:0000835)2.19751939
56Colon cancer (HP:0003003)2.16120681
57CNS demyelination (HP:0007305)2.15486213
58Testicular atrophy (HP:0000029)2.15252590
59Hypoglycemic seizures (HP:0002173)2.14613547
60Megaloblastic anemia (HP:0001889)2.10091483
61Abnormality of renal resorption (HP:0011038)2.09758366
62Abnormality of the nasal septum (HP:0000419)2.08985733
63Abnormality of the renal collecting system (HP:0004742)2.08002715
64Hyperphosphaturia (HP:0003109)2.07781248
65Respiratory difficulties (HP:0002880)2.04347216
66Microvesicular hepatic steatosis (HP:0001414)2.04004031
67Degeneration of anterior horn cells (HP:0002398)2.03317669
68Abnormality of the anterior horn cell (HP:0006802)2.03317669
69Porencephaly (HP:0002132)2.00176242
70Horseshoe kidney (HP:0000085)1.99829998
71Parakeratosis (HP:0001036)1.98997802
72Abnormality of cells of the erythroid lineage (HP:0012130)1.96345178
73Anosmia (HP:0000458)1.90177132
74Hypomagnesemia (HP:0002917)1.85595626
75Congenital ichthyosiform erythroderma (HP:0007431)1.85120357
76Abnormal number of erythroid precursors (HP:0012131)1.84544439
77Dry hair (HP:0011359)1.82408682
78Meckel diverticulum (HP:0002245)1.82134765
79Sparse eyelashes (HP:0000653)1.81361034
80Cellular immunodeficiency (HP:0005374)1.80760255
81Stenosis of the external auditory canal (HP:0000402)1.80551077
82Emotional lability (HP:0000712)1.80427513
83Median cleft lip (HP:0000161)1.80280995
84Abnormal lung lobation (HP:0002101)1.79914450
85Aplastic anemia (HP:0001915)1.79145626
86Pancytopenia (HP:0001876)1.78148821
87Esophageal atresia (HP:0002032)1.76962130
88Abnormality of the preputium (HP:0100587)1.75734315
89Aqueductal stenosis (HP:0002410)1.75167707
90Amniotic constriction ring (HP:0009775)1.73552666
91Abnormality of placental membranes (HP:0011409)1.73552666
92Cleft eyelid (HP:0000625)1.73445507
93Pallor (HP:0000980)1.73289672
94Abnormality of the ileum (HP:0001549)1.71145993
95Anophthalmia (HP:0000528)1.68658137
96Abnormality of midbrain morphology (HP:0002418)1.67974904
97Molar tooth sign on MRI (HP:0002419)1.67974904
98Methylmalonic acidemia (HP:0002912)1.67605151
99Polydipsia (HP:0001959)1.66503354
100Abnormal drinking behavior (HP:0030082)1.66503354

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.76280759
2EIF2AK13.94508898
3MST43.65422572
4STK163.45789158
5TSSK63.05539811
6TRIM282.99649077
7EIF2AK32.84080711
8TAF12.73483417
9BUB12.62159838
10ZAK2.45266005
11VRK12.28857745
12PLK32.26146043
13NEK12.13181348
14PBK2.12177415
15NUAK12.08027308
16CCNB11.99640303
17SRPK11.89143150
18MARK31.84202927
19BRSK21.67992977
20TIE11.66786211
21WEE11.58291970
22CDC71.53020716
23NME11.45648652
24STK41.43148361
25TEC1.42594153
26EPHA41.39814043
27EPHB21.32549426
28STK391.27272148
29EIF2AK21.15769722
30BMPR1B1.14356022
31ACVR1B1.10567914
32TTK1.07478882
33DAPK31.04974352
34PDK21.04129737
35FGR1.01916295
36WNK31.01825747
37FGFR10.98490072
38STK38L0.96030244
39BRSK10.94731392
40MAP3K120.93559590
41DAPK10.93309268
42NME20.93222580
43BMPR20.90837333
44DYRK20.90061063
45WNK40.88796204
46PLK20.81710200
47ILK0.81633472
48MYLK0.81494163
49ATR0.77284714
50CSNK1G10.76228749
51AURKB0.76149662
52FRK0.73810426
53ADRBK20.73182466
54DMPK0.72219735
55TAOK30.71949632
56PLK10.70796553
57PLK40.66079097
58GRK10.65344335
59PAK40.61665408
60PASK0.60771630
61CSNK1G30.60073431
62TLK10.57908890
63ALK0.57696033
64ADRBK10.57376443
65OXSR10.54411813
66MKNK20.53063827
67RPS6KB20.52786368
68PKN10.50600440
69CSNK2A20.50587868
70MKNK10.49666964
71TXK0.48910951
72PRKCG0.48080528
73CHEK20.47609130
74STK240.45268029
75INSRR0.44781168
76CSNK2A10.43849807
77ITK0.42754728
78MAP3K90.42702194
79TGFBR10.42666171
80STK30.40867615
81CSNK1E0.40178160
82MAP2K60.39806483
83CSNK1G20.39699822
84MATK0.39697869
85NLK0.38550989
86CSNK1A1L0.37545685
87MELK0.36633969
88CDK70.36537324
89TNIK0.36347704
90MAPK130.33681556
91FGFR20.29801746
92MAP4K20.29731944
93MINK10.29475299
94IKBKB0.29106968
95PRKDC0.28796123
96GRK50.28126233
97ATM0.27825496
98KDR0.26484492
99CHEK10.25801824
100MAPKAPK30.25643795

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.10061032
2Oxidative phosphorylation_Homo sapiens_hsa001904.73633784
3Ribosome_Homo sapiens_hsa030104.14966769
4Parkinsons disease_Homo sapiens_hsa050123.88380976
5Huntingtons disease_Homo sapiens_hsa050162.75670995
6Protein export_Homo sapiens_hsa030602.72855413
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64833217
8Alzheimers disease_Homo sapiens_hsa050102.57504591
9Non-homologous end-joining_Homo sapiens_hsa034502.56584187
10DNA replication_Homo sapiens_hsa030302.36159355
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.24068150
12RNA polymerase_Homo sapiens_hsa030202.17900810
13Mismatch repair_Homo sapiens_hsa034302.15953715
14Collecting duct acid secretion_Homo sapiens_hsa049662.02924481
15Spliceosome_Homo sapiens_hsa030401.93323072
16Cardiac muscle contraction_Homo sapiens_hsa042601.87749883
17Homologous recombination_Homo sapiens_hsa034401.81461296
18Nucleotide excision repair_Homo sapiens_hsa034201.72553474
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64044340
20Basal transcription factors_Homo sapiens_hsa030221.50973457
21One carbon pool by folate_Homo sapiens_hsa006701.49047390
22RNA degradation_Homo sapiens_hsa030181.48937716
23Pyrimidine metabolism_Homo sapiens_hsa002401.36340121
24Fanconi anemia pathway_Homo sapiens_hsa034601.35522044
25RNA transport_Homo sapiens_hsa030131.34628458
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33777976
27Base excision repair_Homo sapiens_hsa034101.26256648
28Asthma_Homo sapiens_hsa053101.20646549
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20406541
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14911272
31Purine metabolism_Homo sapiens_hsa002301.13242107
32Vitamin B6 metabolism_Homo sapiens_hsa007501.07936576
33Pyruvate metabolism_Homo sapiens_hsa006201.07508950
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07222246
35Nitrogen metabolism_Homo sapiens_hsa009101.05277508
36Cell cycle_Homo sapiens_hsa041101.00444853
37Folate biosynthesis_Homo sapiens_hsa007900.99341756
38Glutathione metabolism_Homo sapiens_hsa004800.97160791
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96625064
40Vitamin digestion and absorption_Homo sapiens_hsa049770.96008873
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89391685
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87322613
43Type I diabetes mellitus_Homo sapiens_hsa049400.86886265
44Rheumatoid arthritis_Homo sapiens_hsa053230.86037612
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.78785282
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.78245971
47Allograft rejection_Homo sapiens_hsa053300.78116976
48Autoimmune thyroid disease_Homo sapiens_hsa053200.77563103
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77181280
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76986676
51Metabolic pathways_Homo sapiens_hsa011000.75649803
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72546076
53Propanoate metabolism_Homo sapiens_hsa006400.71505250
54Graft-versus-host disease_Homo sapiens_hsa053320.70924309
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.68862489
56Phototransduction_Homo sapiens_hsa047440.63493289
57Sulfur relay system_Homo sapiens_hsa041220.63028912
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61028077
59Systemic lupus erythematosus_Homo sapiens_hsa053220.58300680
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58187398
61Vibrio cholerae infection_Homo sapiens_hsa051100.57984794
62Tryptophan metabolism_Homo sapiens_hsa003800.57513613
63Fat digestion and absorption_Homo sapiens_hsa049750.54091109
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.53992516
65Fatty acid elongation_Homo sapiens_hsa000620.53832543
66Carbon metabolism_Homo sapiens_hsa012000.52050541
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49491477
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48982460
69Chemical carcinogenesis_Homo sapiens_hsa052040.48298378
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47778085
71Antigen processing and presentation_Homo sapiens_hsa046120.47152324
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.45595504
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44640004
74beta-Alanine metabolism_Homo sapiens_hsa004100.43498429
75Linoleic acid metabolism_Homo sapiens_hsa005910.43191832
76Epstein-Barr virus infection_Homo sapiens_hsa051690.42684133
77Fatty acid degradation_Homo sapiens_hsa000710.42057872
78Biosynthesis of amino acids_Homo sapiens_hsa012300.41183425
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39031401
80Sulfur metabolism_Homo sapiens_hsa009200.37499651
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36940402
82N-Glycan biosynthesis_Homo sapiens_hsa005100.36768663
83Oocyte meiosis_Homo sapiens_hsa041140.35675265
84Regulation of autophagy_Homo sapiens_hsa041400.34465108
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33423664
86Peroxisome_Homo sapiens_hsa041460.33304674
87mRNA surveillance pathway_Homo sapiens_hsa030150.33229514
88Wnt signaling pathway_Homo sapiens_hsa043100.33032553
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30785320
90Tyrosine metabolism_Homo sapiens_hsa003500.29708122
91Selenocompound metabolism_Homo sapiens_hsa004500.29107353
92Arachidonic acid metabolism_Homo sapiens_hsa005900.28467910
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27718613
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27546053
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26514298
96Caffeine metabolism_Homo sapiens_hsa002320.25646671
97Butanoate metabolism_Homo sapiens_hsa006500.25632412
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.23445098
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.22571539
100Synaptic vesicle cycle_Homo sapiens_hsa047210.22130161

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