

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 5.30724400 |
| 2 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 5.30724400 |
| 3 | DNA replication checkpoint (GO:0000076) | 5.26881317 |
| 4 | response to pheromone (GO:0019236) | 4.65138698 |
| 5 | proteasome assembly (GO:0043248) | 4.51392015 |
| 6 | regulation of centriole replication (GO:0046599) | 4.41606107 |
| 7 | synapsis (GO:0007129) | 4.37985222 |
| 8 | pseudouridine synthesis (GO:0001522) | 4.25901393 |
| 9 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.14258463 |
| 10 | DNA deamination (GO:0045006) | 4.06752434 |
| 11 | negative regulation of Notch signaling pathway (GO:0045746) | 4.05287439 |
| 12 | base-excision repair, AP site formation (GO:0006285) | 4.02584806 |
| 13 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.97042626 |
| 14 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.93397508 |
| 15 | positive regulation of viral genome replication (GO:0045070) | 3.91299329 |
| 16 | regulation of chronic inflammatory response (GO:0002676) | 3.86812307 |
| 17 | termination of RNA polymerase I transcription (GO:0006363) | 3.82203657 |
| 18 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.79402008 |
| 19 | negative regulation of ligase activity (GO:0051352) | 3.79402008 |
| 20 | resolution of meiotic recombination intermediates (GO:0000712) | 3.74935841 |
| 21 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.66619777 |
| 22 | lactate metabolic process (GO:0006089) | 3.65921252 |
| 23 | arginine catabolic process (GO:0006527) | 3.61273821 |
| 24 | regulation of oxidative phosphorylation (GO:0002082) | 3.60820899 |
| 25 | postreplication repair (GO:0006301) | 3.60785279 |
| 26 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.60502625 |
| 27 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.60502625 |
| 28 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.60502625 |
| 29 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.59533859 |
| 30 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.59533859 |
| 31 | mitochondrial RNA metabolic process (GO:0000959) | 3.52235682 |
| 32 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.51708228 |
| 33 | regulation of oxidative stress-induced neuron death (GO:1903203) | 3.51423111 |
| 34 | protein K6-linked ubiquitination (GO:0085020) | 3.48335087 |
| 35 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.46386508 |
| 36 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.46386508 |
| 37 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.43540785 |
| 38 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.42939064 |
| 39 | electron transport chain (GO:0022900) | 3.42010505 |
| 40 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.40760549 |
| 41 | respiratory electron transport chain (GO:0022904) | 3.40040336 |
| 42 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.32874294 |
| 43 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.30871645 |
| 44 | termination of RNA polymerase III transcription (GO:0006386) | 3.30871645 |
| 45 | positive regulation of ligase activity (GO:0051351) | 3.30145444 |
| 46 | respiratory chain complex IV assembly (GO:0008535) | 3.26876956 |
| 47 | dopamine transport (GO:0015872) | 3.25903834 |
| 48 | autophagic vacuole fusion (GO:0000046) | 3.24520660 |
| 49 | negative regulation of fatty acid biosynthetic process (GO:0045717) | 3.24498667 |
| 50 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.23407072 |
| 51 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.22665874 |
| 52 | transcription from RNA polymerase I promoter (GO:0006360) | 3.21424844 |
| 53 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.20429965 |
| 54 | cytochrome complex assembly (GO:0017004) | 3.19549669 |
| 55 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.15345450 |
| 56 | CENP-A containing nucleosome assembly (GO:0034080) | 3.13929397 |
| 57 | protein complex biogenesis (GO:0070271) | 3.12405711 |
| 58 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.11835414 |
| 59 | tRNA aminoacylation (GO:0043039) | 3.10632165 |
| 60 | amino acid activation (GO:0043038) | 3.10632165 |
| 61 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.10366527 |
| 62 | ribosomal small subunit assembly (GO:0000028) | 3.10286836 |
| 63 | tRNA processing (GO:0008033) | 3.09788830 |
| 64 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.07465875 |
| 65 | protein deneddylation (GO:0000338) | 3.06812859 |
| 66 | DNA strand elongation (GO:0022616) | 3.06368755 |
| 67 | tRNA metabolic process (GO:0006399) | 3.06112015 |
| 68 | tRNA modification (GO:0006400) | 3.04511768 |
| 69 | telomere maintenance via recombination (GO:0000722) | 3.04462038 |
| 70 | ribosome biogenesis (GO:0042254) | 3.03665331 |
| 71 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.03405740 |
| 72 | positive regulation of protein homodimerization activity (GO:0090073) | 3.03024802 |
| 73 | spliceosomal snRNP assembly (GO:0000387) | 3.02595929 |
| 74 | regulation of ligase activity (GO:0051340) | 3.01924674 |
| 75 | ATP synthesis coupled proton transport (GO:0015986) | 3.01037676 |
| 76 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.01037676 |
| 77 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.97465824 |
| 78 | transcription from mitochondrial promoter (GO:0006390) | 2.96223299 |
| 79 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.96137935 |
| 80 | tRNA aminoacylation for protein translation (GO:0006418) | 2.94964780 |
| 81 | cullin deneddylation (GO:0010388) | 2.94402314 |
| 82 | regulation of cellular respiration (GO:0043457) | 2.94247874 |
| 83 | chromatin remodeling at centromere (GO:0031055) | 2.94022754 |
| 84 | meiotic chromosome segregation (GO:0045132) | 2.93473553 |
| 85 | kinetochore assembly (GO:0051382) | 2.93083502 |
| 86 | negative regulation of protein acetylation (GO:1901984) | 2.91273919 |
| 87 | purine deoxyribonucleotide catabolic process (GO:0009155) | 2.90771346 |
| 88 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.90501574 |
| 89 | rRNA modification (GO:0000154) | 2.89094383 |
| 90 | chaperone-mediated protein transport (GO:0072321) | 2.87218427 |
| 91 | arginine metabolic process (GO:0006525) | 2.86153546 |
| 92 | positive regulation of cell cycle arrest (GO:0071158) | 2.85832679 |
| 93 | regulation of cellular amine metabolic process (GO:0033238) | 2.83909368 |
| 94 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.82798955 |
| 95 | regulation of mitochondrial translation (GO:0070129) | 2.82694681 |
| 96 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.79756570 |
| 97 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.77836409 |
| 98 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.77836409 |
| 99 | NADH dehydrogenase complex assembly (GO:0010257) | 2.77836409 |
| 100 | organelle membrane fusion (GO:0090174) | 2.76866744 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.45825972 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.05093165 |
| 3 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 4.00075285 |
| 4 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.94438374 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.93876235 |
| 6 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.79968309 |
| 7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.65808120 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.37023001 |
| 9 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.11446036 |
| 10 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.99612310 |
| 11 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.77250369 |
| 12 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.64878693 |
| 13 | VDR_22108803_ChIP-Seq_LS180_Human | 2.60749998 |
| 14 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.59161628 |
| 15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.58530321 |
| 16 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.56462954 |
| 17 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.49410974 |
| 18 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.46409700 |
| 19 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.43646237 |
| 20 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.41413570 |
| 21 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.24746945 |
| 22 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.22503929 |
| 23 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.21091523 |
| 24 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.13862427 |
| 25 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.09268081 |
| 26 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.06187173 |
| 27 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.05544199 |
| 28 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.04493695 |
| 29 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.04297984 |
| 30 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.96909015 |
| 31 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.96754484 |
| 32 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.88693804 |
| 33 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.81901983 |
| 34 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.77740615 |
| 35 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.71135937 |
| 36 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.67700783 |
| 37 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.65380370 |
| 38 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.65230816 |
| 39 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.65182343 |
| 40 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.59727982 |
| 41 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.55615769 |
| 42 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.52937467 |
| 43 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.50481945 |
| 44 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.48797300 |
| 45 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.47492273 |
| 46 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.43571163 |
| 47 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.34506048 |
| 48 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.29958835 |
| 49 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.28758494 |
| 50 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.27422936 |
| 51 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.26046579 |
| 52 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.25519284 |
| 53 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.24133550 |
| 54 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.23311520 |
| 55 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.22413312 |
| 56 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.18716941 |
| 57 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.16624452 |
| 58 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.14561563 |
| 59 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.14258061 |
| 60 | P53_21459846_ChIP-Seq_SAOS-2_Human | 1.12263759 |
| 61 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.11791354 |
| 62 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.04189571 |
| 63 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.04136265 |
| 64 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.01191818 |
| 65 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.00100691 |
| 66 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.98931900 |
| 67 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.96113232 |
| 68 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.95600721 |
| 69 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.95034753 |
| 70 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.94822574 |
| 71 | GATA1_22025678_ChIP-Seq_K562_Human | 0.94707123 |
| 72 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.93052221 |
| 73 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.92856545 |
| 74 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.92268636 |
| 75 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.91929572 |
| 76 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.91781248 |
| 77 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.91289868 |
| 78 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.90239582 |
| 79 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.89313041 |
| 80 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.89176680 |
| 81 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.86000671 |
| 82 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.81051792 |
| 83 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.80687766 |
| 84 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.80608386 |
| 85 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.80344765 |
| 86 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.80218356 |
| 87 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.79644871 |
| 88 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.78156159 |
| 89 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.78150589 |
| 90 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.78096561 |
| 91 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.76193115 |
| 92 | NCOR_22424771_ChIP-Seq_293T_Human | 0.73045562 |
| 93 | GATA3_26560356_Chip-Seq_TH2_Human | 0.72922496 |
| 94 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.71952462 |
| 95 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.70566946 |
| 96 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.70193209 |
| 97 | EWS_26573619_Chip-Seq_HEK293_Human | 0.69683105 |
| 98 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.69528424 |
| 99 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.69500681 |
| 100 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.68421922 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008995_early_reproductive_senescence | 4.37751704 |
| 2 | MP0003786_premature_aging | 4.03190651 |
| 3 | MP0004147_increased_porphyrin_level | 3.69119598 |
| 4 | MP0008058_abnormal_DNA_repair | 3.34892501 |
| 5 | MP0001873_stomach_inflammation | 3.32315065 |
| 6 | MP0010094_abnormal_chromosome_stability | 3.17414661 |
| 7 | MP0005083_abnormal_biliary_tract | 3.17343014 |
| 8 | MP0001529_abnormal_vocalization | 3.01788948 |
| 9 | MP0003693_abnormal_embryo_hatching | 2.92357065 |
| 10 | MP0005360_urolithiasis | 2.87258993 |
| 11 | MP0008875_abnormal_xenobiotic_pharmacok | 2.76255205 |
| 12 | MP0008872_abnormal_physiological_respon | 2.62176920 |
| 13 | MP0005646_abnormal_pituitary_gland | 2.61769619 |
| 14 | MP0003111_abnormal_nucleus_morphology | 2.60217882 |
| 15 | MP0005167_abnormal_blood-brain_barrier | 2.24310769 |
| 16 | MP0003656_abnormal_erythrocyte_physiolo | 2.21851028 |
| 17 | MP0001919_abnormal_reproductive_system | 2.17192554 |
| 18 | MP0003941_abnormal_skin_development | 2.16887015 |
| 19 | MP0003718_maternal_effect | 2.15543280 |
| 20 | MP0002160_abnormal_reproductive_system | 2.14779822 |
| 21 | MP0008057_abnormal_DNA_replication | 2.11793373 |
| 22 | MP0004957_abnormal_blastocyst_morpholog | 2.09496813 |
| 23 | MP0005389_reproductive_system_phenotype | 2.06088030 |
| 24 | MP0005310_abnormal_salivary_gland | 1.94378673 |
| 25 | MP0006035_abnormal_mitochondrial_morpho | 1.79937180 |
| 26 | MP0004142_abnormal_muscle_tone | 1.61999959 |
| 27 | MP0006036_abnormal_mitochondrial_physio | 1.61396869 |
| 28 | MP0004019_abnormal_vitamin_homeostasis | 1.59920672 |
| 29 | MP0000358_abnormal_cell_content/ | 1.56238939 |
| 30 | MP0000685_abnormal_immune_system | 1.54635415 |
| 31 | MP0009697_abnormal_copulation | 1.53777855 |
| 32 | MP0005636_abnormal_mineral_homeostasis | 1.50604292 |
| 33 | MP0002163_abnormal_gland_morphology | 1.47976804 |
| 34 | MP0003195_calcinosis | 1.47320996 |
| 35 | MP0009333_abnormal_splenocyte_physiolog | 1.44568530 |
| 36 | MP0003077_abnormal_cell_cycle | 1.43838186 |
| 37 | MP0001929_abnormal_gametogenesis | 1.35078168 |
| 38 | MP0000647_abnormal_sebaceous_gland | 1.25679474 |
| 39 | MP0000372_irregular_coat_pigmentation | 1.23930111 |
| 40 | MP0002102_abnormal_ear_morphology | 1.23387994 |
| 41 | MP0000613_abnormal_salivary_gland | 1.21513925 |
| 42 | MP0005410_abnormal_fertilization | 1.21430280 |
| 43 | MP0002210_abnormal_sex_determination | 1.20259140 |
| 44 | MP0002006_tumorigenesis | 1.18335154 |
| 45 | MP0005365_abnormal_bile_salt | 1.13931718 |
| 46 | MP0000427_abnormal_hair_cycle | 1.12524804 |
| 47 | MP0003936_abnormal_reproductive_system | 1.12004325 |
| 48 | MP0005671_abnormal_response_to | 1.10677058 |
| 49 | MP0001881_abnormal_mammary_gland | 1.10447572 |
| 50 | MP0002396_abnormal_hematopoietic_system | 1.09170256 |
| 51 | MP0006276_abnormal_autonomic_nervous | 1.07653495 |
| 52 | MP0006292_abnormal_olfactory_placode | 1.03919932 |
| 53 | MP0001835_abnormal_antigen_presentation | 1.00175120 |
| 54 | MP0004145_abnormal_muscle_electrophysio | 0.98812755 |
| 55 | MP0004947_skin_inflammation | 0.98692055 |
| 56 | MP0000653_abnormal_sex_gland | 0.98101091 |
| 57 | MP0002138_abnormal_hepatobiliary_system | 0.96674877 |
| 58 | MP0001790_abnormal_immune_system | 0.95705539 |
| 59 | MP0005387_immune_system_phenotype | 0.95705539 |
| 60 | MP0001984_abnormal_olfaction | 0.93322934 |
| 61 | MP0008932_abnormal_embryonic_tissue | 0.92116508 |
| 62 | MP0001119_abnormal_female_reproductive | 0.90333474 |
| 63 | MP0004133_heterotaxia | 0.89669667 |
| 64 | MP0006072_abnormal_retinal_apoptosis | 0.88133268 |
| 65 | MP0005332_abnormal_amino_acid | 0.86022565 |
| 66 | MP0008877_abnormal_DNA_methylation | 0.85405127 |
| 67 | MP0004043_abnormal_pH_regulation | 0.85097195 |
| 68 | MP0005085_abnormal_gallbladder_physiolo | 0.85084074 |
| 69 | MP0001145_abnormal_male_reproductive | 0.83893133 |
| 70 | MP0002148_abnormal_hypersensitivity_rea | 0.83670369 |
| 71 | MP0001764_abnormal_homeostasis | 0.77855669 |
| 72 | MP0010307_abnormal_tumor_latency | 0.75181422 |
| 73 | MP0000313_abnormal_cell_death | 0.74653459 |
| 74 | MP0009785_altered_susceptibility_to | 0.74193609 |
| 75 | MP0001243_abnormal_dermal_layer | 0.73576509 |
| 76 | MP0000689_abnormal_spleen_morphology | 0.73246486 |
| 77 | MP0002166_altered_tumor_susceptibility | 0.73005568 |
| 78 | MP0002019_abnormal_tumor_incidence | 0.71833303 |
| 79 | MP0002132_abnormal_respiratory_system | 0.71486399 |
| 80 | MP0005379_endocrine/exocrine_gland_phen | 0.69994848 |
| 81 | MP0001348_abnormal_lacrimal_gland | 0.69704336 |
| 82 | MP0000703_abnormal_thymus_morphology | 0.69475915 |
| 83 | MP0002928_abnormal_bile_duct | 0.69314025 |
| 84 | MP0002398_abnormal_bone_marrow | 0.68525261 |
| 85 | MP0000609_abnormal_liver_physiology | 0.68292165 |
| 86 | MP0001905_abnormal_dopamine_level | 0.66848734 |
| 87 | MP0002722_abnormal_immune_system | 0.65715234 |
| 88 | MP0003698_abnormal_male_reproductive | 0.65584141 |
| 89 | MP0003699_abnormal_female_reproductive | 0.65448696 |
| 90 | MP0002429_abnormal_blood_cell | 0.64963983 |
| 91 | MP0001800_abnormal_humoral_immune | 0.64355340 |
| 92 | MP0001666_abnormal_nutrient_absorption | 0.61830128 |
| 93 | MP0000678_abnormal_parathyroid_gland | 0.60255866 |
| 94 | MP0003646_muscle_fatigue | 0.59960631 |
| 95 | MP0001663_abnormal_digestive_system | 0.57954543 |
| 96 | MP0003186_abnormal_redox_activity | 0.57879117 |
| 97 | MP0001501_abnormal_sleep_pattern | 0.56714399 |
| 98 | MP0001765_abnormal_ion_homeostasis | 0.56003529 |
| 99 | MP0008770_decreased_survivor_rate | 0.55625140 |
| 100 | MP0002693_abnormal_pancreas_physiology | 0.55423314 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.57171379 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.30926912 |
| 3 | Acute encephalopathy (HP:0006846) | 4.93897590 |
| 4 | Birth length less than 3rd percentile (HP:0003561) | 4.67714335 |
| 5 | Progressive macrocephaly (HP:0004481) | 4.49791975 |
| 6 | Mitochondrial inheritance (HP:0001427) | 4.46618439 |
| 7 | Increased CSF lactate (HP:0002490) | 4.43027675 |
| 8 | Cerebral edema (HP:0002181) | 4.20979560 |
| 9 | Hepatocellular necrosis (HP:0001404) | 3.85545333 |
| 10 | Breech presentation (HP:0001623) | 3.78890921 |
| 11 | Hepatic necrosis (HP:0002605) | 3.61217472 |
| 12 | Aplastic anemia (HP:0001915) | 3.56286480 |
| 13 | Increased hepatocellular lipid droplets (HP:0006565) | 3.37518323 |
| 14 | Septate vagina (HP:0001153) | 3.37047341 |
| 15 | Abnormal biliary tract physiology (HP:0012439) | 3.26754022 |
| 16 | Bile duct proliferation (HP:0001408) | 3.26754022 |
| 17 | Lipid accumulation in hepatocytes (HP:0006561) | 3.18621718 |
| 18 | Abnormality of the preputium (HP:0100587) | 3.04203143 |
| 19 | Seborrheic dermatitis (HP:0001051) | 3.02035959 |
| 20 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.81622533 |
| 21 | Concave nail (HP:0001598) | 2.81285632 |
| 22 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.75346055 |
| 23 | Increased serum lactate (HP:0002151) | 2.75073411 |
| 24 | Meckel diverticulum (HP:0002245) | 2.72326162 |
| 25 | Supernumerary spleens (HP:0009799) | 2.72050588 |
| 26 | Hyperthyroidism (HP:0000836) | 2.66558646 |
| 27 | Abnormality of the ileum (HP:0001549) | 2.63728633 |
| 28 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.58921289 |
| 29 | Asplenia (HP:0001746) | 2.58293886 |
| 30 | Pancreatic fibrosis (HP:0100732) | 2.54301707 |
| 31 | 3-Methylglutaconic aciduria (HP:0003535) | 2.52876452 |
| 32 | Truncus arteriosus (HP:0001660) | 2.52460939 |
| 33 | Chromsome breakage (HP:0040012) | 2.50683035 |
| 34 | Pancreatic cysts (HP:0001737) | 2.49895018 |
| 35 | Duplicated collecting system (HP:0000081) | 2.49685652 |
| 36 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.42930659 |
| 37 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.39884288 |
| 38 | Exercise intolerance (HP:0003546) | 2.39570085 |
| 39 | Increased intramyocellular lipid droplets (HP:0012240) | 2.36483181 |
| 40 | Lactic acidosis (HP:0003128) | 2.36447338 |
| 41 | Abnormality of the pons (HP:0007361) | 2.35970975 |
| 42 | Respiratory failure (HP:0002878) | 2.30412590 |
| 43 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 2.30311200 |
| 44 | Single umbilical artery (HP:0001195) | 2.29749230 |
| 45 | Abnormality of the fetal cardiovascular system (HP:0010948) | 2.29749230 |
| 46 | Abnormal umbilical cord blood vessels (HP:0011403) | 2.29749230 |
| 47 | Poor suck (HP:0002033) | 2.28005257 |
| 48 | Optic disc pallor (HP:0000543) | 2.26473574 |
| 49 | Abnormal number of erythroid precursors (HP:0012131) | 2.24505564 |
| 50 | Esophageal neoplasm (HP:0100751) | 2.23182181 |
| 51 | Neoplasm of head and neck (HP:0012288) | 2.23182181 |
| 52 | Abnormality of the renal collecting system (HP:0004742) | 2.22728703 |
| 53 | Exertional dyspnea (HP:0002875) | 2.18589317 |
| 54 | IgG deficiency (HP:0004315) | 2.16916219 |
| 55 | Generalized aminoaciduria (HP:0002909) | 2.16802018 |
| 56 | Pancytopenia (HP:0001876) | 2.15586457 |
| 57 | Hypoplasia of the pons (HP:0012110) | 2.13573466 |
| 58 | Abnormality of the carotid arteries (HP:0005344) | 2.11916939 |
| 59 | Abnormal gallbladder physiology (HP:0012438) | 2.10925926 |
| 60 | Cholecystitis (HP:0001082) | 2.10925926 |
| 61 | Sclerocornea (HP:0000647) | 2.10274383 |
| 62 | Leukodystrophy (HP:0002415) | 2.09797176 |
| 63 | Lethargy (HP:0001254) | 2.09410709 |
| 64 | True hermaphroditism (HP:0010459) | 2.09302117 |
| 65 | Breast hypoplasia (HP:0003187) | 2.05002654 |
| 66 | Hypertensive crisis (HP:0100735) | 2.04478627 |
| 67 | Dry hair (HP:0011359) | 2.03888399 |
| 68 | Premature skin wrinkling (HP:0100678) | 2.03534518 |
| 69 | Duodenal stenosis (HP:0100867) | 2.01680250 |
| 70 | Small intestinal stenosis (HP:0012848) | 2.01680250 |
| 71 | Abnormality of chromosome stability (HP:0003220) | 2.01198283 |
| 72 | Renal Fanconi syndrome (HP:0001994) | 2.00528081 |
| 73 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.98369855 |
| 74 | Respiratory difficulties (HP:0002880) | 1.96963605 |
| 75 | Increased muscle lipid content (HP:0009058) | 1.96404268 |
| 76 | Clubbing of toes (HP:0100760) | 1.95778143 |
| 77 | Cerebral hypomyelination (HP:0006808) | 1.94955383 |
| 78 | Type II lissencephaly (HP:0007260) | 1.94889798 |
| 79 | Patellar aplasia (HP:0006443) | 1.90654926 |
| 80 | Abnormality of DNA repair (HP:0003254) | 1.90587262 |
| 81 | Progressive microcephaly (HP:0000253) | 1.86195548 |
| 82 | Self-mutilation (HP:0000742) | 1.85107535 |
| 83 | Abnormality of the tricuspid valve (HP:0001702) | 1.84226792 |
| 84 | CNS demyelination (HP:0007305) | 1.80784825 |
| 85 | Horseshoe kidney (HP:0000085) | 1.80209522 |
| 86 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.79883688 |
| 87 | Abnormality of the labia minora (HP:0012880) | 1.79473147 |
| 88 | Blindness (HP:0000618) | 1.75621389 |
| 89 | Emotional lability (HP:0000712) | 1.75235751 |
| 90 | Vomiting (HP:0002013) | 1.74532905 |
| 91 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.74199725 |
| 92 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.74199725 |
| 93 | Severe combined immunodeficiency (HP:0004430) | 1.73985507 |
| 94 | Increased serum pyruvate (HP:0003542) | 1.73440431 |
| 95 | Large for gestational age (HP:0001520) | 1.72808115 |
| 96 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.72621477 |
| 97 | Stomatitis (HP:0010280) | 1.69244337 |
| 98 | Abnormality of cochlea (HP:0000375) | 1.69080571 |
| 99 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.67808428 |
| 100 | Hyperalaninemia (HP:0003348) | 1.67808428 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PLK4 | 5.74410825 |
| 2 | MAP4K2 | 3.91138007 |
| 3 | EIF2AK1 | 3.01395648 |
| 4 | NME1 | 2.89188435 |
| 5 | TSSK6 | 2.81749540 |
| 6 | PBK | 2.80494902 |
| 7 | MST4 | 2.65559247 |
| 8 | SRPK1 | 2.47715342 |
| 9 | PLK2 | 2.47108304 |
| 10 | EIF2AK3 | 2.46541466 |
| 11 | VRK2 | 2.15768584 |
| 12 | BUB1 | 2.08922899 |
| 13 | ADRBK2 | 1.99070042 |
| 14 | TLK1 | 1.89382697 |
| 15 | ZAK | 1.86733800 |
| 16 | BCKDK | 1.83104164 |
| 17 | MAP3K12 | 1.82635272 |
| 18 | WNK4 | 1.82182263 |
| 19 | TRIM28 | 1.81997725 |
| 20 | CLK1 | 1.55995073 |
| 21 | NUAK1 | 1.53704205 |
| 22 | CDC7 | 1.51643921 |
| 23 | KDR | 1.44242321 |
| 24 | CDK8 | 1.42425337 |
| 25 | PDK2 | 1.39860291 |
| 26 | MAPKAPK3 | 1.37849231 |
| 27 | TAOK3 | 1.34404146 |
| 28 | CHEK2 | 1.33458375 |
| 29 | ALK | 1.22075588 |
| 30 | DAPK1 | 1.22002203 |
| 31 | ATR | 1.21165569 |
| 32 | OXSR1 | 1.12312091 |
| 33 | BMPR1B | 1.11716294 |
| 34 | GRK1 | 1.11155618 |
| 35 | NME2 | 1.10894002 |
| 36 | TTK | 1.09813979 |
| 37 | VRK1 | 1.08997488 |
| 38 | ACVR1B | 1.08179575 |
| 39 | MAP3K11 | 0.98656249 |
| 40 | EIF2AK2 | 0.97757328 |
| 41 | NEK1 | 0.95741658 |
| 42 | PLK3 | 0.93668461 |
| 43 | PLK1 | 0.90940780 |
| 44 | PASK | 0.87270497 |
| 45 | TGFBR1 | 0.85686579 |
| 46 | STK4 | 0.84916675 |
| 47 | TNK2 | 0.79849121 |
| 48 | MAP2K6 | 0.78251416 |
| 49 | PINK1 | 0.76391538 |
| 50 | STK39 | 0.75758748 |
| 51 | MAP3K4 | 0.75684145 |
| 52 | BRSK1 | 0.74919441 |
| 53 | RPS6KA5 | 0.74805910 |
| 54 | RIPK4 | 0.70104588 |
| 55 | WNK3 | 0.69246148 |
| 56 | CDK3 | 0.65651274 |
| 57 | CSNK2A1 | 0.64743240 |
| 58 | MATK | 0.59054440 |
| 59 | CSNK2A2 | 0.58099055 |
| 60 | AURKA | 0.57040181 |
| 61 | BRSK2 | 0.53837111 |
| 62 | PIM1 | 0.51080649 |
| 63 | WEE1 | 0.49976917 |
| 64 | GRK5 | 0.49860645 |
| 65 | IKBKB | 0.49805623 |
| 66 | CSNK1G3 | 0.49559160 |
| 67 | ATM | 0.48636512 |
| 68 | PIK3CG | 0.48044454 |
| 69 | CDK4 | 0.47111926 |
| 70 | GRK6 | 0.46805871 |
| 71 | MYLK | 0.44416055 |
| 72 | FLT3 | 0.44409538 |
| 73 | MAPK12 | 0.42500072 |
| 74 | TEC | 0.41620423 |
| 75 | CSNK1A1L | 0.41069213 |
| 76 | MAP2K4 | 0.40018245 |
| 77 | BMX | 0.37760015 |
| 78 | CHEK1 | 0.37467051 |
| 79 | CSNK1A1 | 0.37025475 |
| 80 | ADRBK1 | 0.36938239 |
| 81 | PAK1 | 0.36599746 |
| 82 | PRKCI | 0.36506898 |
| 83 | MAP3K8 | 0.35964161 |
| 84 | NTRK1 | 0.34717655 |
| 85 | MAP2K7 | 0.34626646 |
| 86 | MARK3 | 0.33727882 |
| 87 | MAPK13 | 0.33666809 |
| 88 | MKNK1 | 0.33570391 |
| 89 | NEK2 | 0.32491074 |
| 90 | STK16 | 0.30880234 |
| 91 | MAP2K2 | 0.29375657 |
| 92 | PHKG2 | 0.28901373 |
| 93 | PHKG1 | 0.28901373 |
| 94 | CDK1 | 0.28451180 |
| 95 | CDK7 | 0.28243278 |
| 96 | KSR2 | 0.28099482 |
| 97 | AURKB | 0.26455098 |
| 98 | TIE1 | 0.26446098 |
| 99 | CAMK1 | 0.26025397 |
| 100 | FES | 0.25572512 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.83938739 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.14092440 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.99870970 |
| 4 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.99237104 |
| 5 | Homologous recombination_Homo sapiens_hsa03440 | 2.98415441 |
| 6 | DNA replication_Homo sapiens_hsa03030 | 2.94858735 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 2.85098449 |
| 8 | Mismatch repair_Homo sapiens_hsa03430 | 2.84681618 |
| 9 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.81365426 |
| 10 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.57026502 |
| 11 | Base excision repair_Homo sapiens_hsa03410 | 2.54542951 |
| 12 | Parkinsons disease_Homo sapiens_hsa05012 | 2.33277692 |
| 13 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.29826715 |
| 14 | Basal transcription factors_Homo sapiens_hsa03022 | 2.17838079 |
| 15 | Ribosome_Homo sapiens_hsa03010 | 2.14861489 |
| 16 | Protein export_Homo sapiens_hsa03060 | 2.07399833 |
| 17 | Spliceosome_Homo sapiens_hsa03040 | 2.01167390 |
| 18 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.89664891 |
| 19 | RNA transport_Homo sapiens_hsa03013 | 1.85717376 |
| 20 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.71553493 |
| 21 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.71278730 |
| 22 | Asthma_Homo sapiens_hsa05310 | 1.70913601 |
| 23 | Huntingtons disease_Homo sapiens_hsa05016 | 1.64281777 |
| 24 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.62957632 |
| 25 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.60237074 |
| 26 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.57517550 |
| 27 | RNA degradation_Homo sapiens_hsa03018 | 1.53048136 |
| 28 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.43134032 |
| 29 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.35797881 |
| 30 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.34448631 |
| 31 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.29043203 |
| 32 | Alzheimers disease_Homo sapiens_hsa05010 | 1.28951397 |
| 33 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.26492025 |
| 34 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.19845205 |
| 35 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.17812295 |
| 36 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.17191747 |
| 37 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.15966583 |
| 38 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.15501860 |
| 39 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.04416207 |
| 40 | Olfactory transduction_Homo sapiens_hsa04740 | 1.03633760 |
| 41 | Allograft rejection_Homo sapiens_hsa05330 | 0.99345232 |
| 42 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.95957886 |
| 43 | Purine metabolism_Homo sapiens_hsa00230 | 0.94980071 |
| 44 | Cell cycle_Homo sapiens_hsa04110 | 0.90036811 |
| 45 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.86458283 |
| 46 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.84247144 |
| 47 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.83181579 |
| 48 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.81552203 |
| 49 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.80473397 |
| 50 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.78684451 |
| 51 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.78104023 |
| 52 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.73961423 |
| 53 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.73854347 |
| 54 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.72236123 |
| 55 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.70573882 |
| 56 | Metabolic pathways_Homo sapiens_hsa01100 | 0.68601435 |
| 57 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.66740753 |
| 58 | Carbon metabolism_Homo sapiens_hsa01200 | 0.63812672 |
| 59 | Mineral absorption_Homo sapiens_hsa04978 | 0.62393109 |
| 60 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.61148670 |
| 61 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.57293009 |
| 62 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.56896105 |
| 63 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.55361450 |
| 64 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.53885144 |
| 65 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.53393583 |
| 66 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.48958668 |
| 67 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.48905965 |
| 68 | Retinol metabolism_Homo sapiens_hsa00830 | 0.48394434 |
| 69 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.47785618 |
| 70 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.44852544 |
| 71 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.43118014 |
| 72 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.42546123 |
| 73 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.41937370 |
| 74 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.40720168 |
| 75 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.39991148 |
| 76 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.39327294 |
| 77 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.39188392 |
| 78 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.38498221 |
| 79 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.37964620 |
| 80 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.35212930 |
| 81 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.34367585 |
| 82 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.34126744 |
| 83 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.33213836 |
| 84 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.32798042 |
| 85 | Phototransduction_Homo sapiens_hsa04744 | 0.31190593 |
| 86 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.30220845 |
| 87 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.26737804 |
| 88 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.25211559 |
| 89 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.24175835 |
| 90 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.23794697 |
| 91 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.22603140 |
| 92 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.19093762 |
| 93 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.18584477 |
| 94 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.18396577 |
| 95 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.18039328 |
| 96 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.17902277 |
| 97 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.17436611 |
| 98 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.17158859 |
| 99 | Taste transduction_Homo sapiens_hsa04742 | 0.16679175 |
| 100 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.16284908 |

