PHBP11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.30724400
2tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.30724400
3DNA replication checkpoint (GO:0000076)5.26881317
4response to pheromone (GO:0019236)4.65138698
5proteasome assembly (GO:0043248)4.51392015
6regulation of centriole replication (GO:0046599)4.41606107
7synapsis (GO:0007129)4.37985222
8pseudouridine synthesis (GO:0001522)4.25901393
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.14258463
10DNA deamination (GO:0045006)4.06752434
11negative regulation of Notch signaling pathway (GO:0045746)4.05287439
12base-excision repair, AP site formation (GO:0006285)4.02584806
13regulation of cellular amino acid metabolic process (GO:0006521)3.97042626
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.93397508
15positive regulation of viral genome replication (GO:0045070)3.91299329
16regulation of chronic inflammatory response (GO:0002676)3.86812307
17termination of RNA polymerase I transcription (GO:0006363)3.82203657
18negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.79402008
19negative regulation of ligase activity (GO:0051352)3.79402008
20resolution of meiotic recombination intermediates (GO:0000712)3.74935841
21DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.66619777
22lactate metabolic process (GO:0006089)3.65921252
23arginine catabolic process (GO:0006527)3.61273821
24regulation of oxidative phosphorylation (GO:0002082)3.60820899
25postreplication repair (GO:0006301)3.60785279
26signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.60502625
27signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.60502625
28signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.60502625
29signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.59533859
30intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.59533859
31mitochondrial RNA metabolic process (GO:0000959)3.52235682
32positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.51708228
33regulation of oxidative stress-induced neuron death (GO:1903203)3.51423111
34protein K6-linked ubiquitination (GO:0085020)3.48335087
35signal transduction involved in DNA damage checkpoint (GO:0072422)3.46386508
36signal transduction involved in DNA integrity checkpoint (GO:0072401)3.46386508
37positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.43540785
38regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.42939064
39electron transport chain (GO:0022900)3.42010505
40signal transduction involved in cell cycle checkpoint (GO:0072395)3.40760549
41respiratory electron transport chain (GO:0022904)3.40040336
42DNA strand elongation involved in DNA replication (GO:0006271)3.32874294
43transcription elongation from RNA polymerase III promoter (GO:0006385)3.30871645
44termination of RNA polymerase III transcription (GO:0006386)3.30871645
45positive regulation of ligase activity (GO:0051351)3.30145444
46respiratory chain complex IV assembly (GO:0008535)3.26876956
47dopamine transport (GO:0015872)3.25903834
48autophagic vacuole fusion (GO:0000046)3.24520660
49negative regulation of fatty acid biosynthetic process (GO:0045717)3.24498667
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.23407072
51exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.22665874
52transcription from RNA polymerase I promoter (GO:0006360)3.21424844
53telomere maintenance via semi-conservative replication (GO:0032201)3.20429965
54cytochrome complex assembly (GO:0017004)3.19549669
55transcription initiation from RNA polymerase I promoter (GO:0006361)3.15345450
56CENP-A containing nucleosome assembly (GO:0034080)3.13929397
57protein complex biogenesis (GO:0070271)3.12405711
58regulation of ubiquitin-protein transferase activity (GO:0051438)3.11835414
59tRNA aminoacylation (GO:0043039)3.10632165
60amino acid activation (GO:0043038)3.10632165
61transcription elongation from RNA polymerase I promoter (GO:0006362)3.10366527
62ribosomal small subunit assembly (GO:0000028)3.10286836
63tRNA processing (GO:0008033)3.09788830
64nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07465875
65protein deneddylation (GO:0000338)3.06812859
66DNA strand elongation (GO:0022616)3.06368755
67tRNA metabolic process (GO:0006399)3.06112015
68tRNA modification (GO:0006400)3.04511768
69telomere maintenance via recombination (GO:0000722)3.04462038
70ribosome biogenesis (GO:0042254)3.03665331
71folic acid-containing compound biosynthetic process (GO:0009396)3.03405740
72positive regulation of protein homodimerization activity (GO:0090073)3.03024802
73spliceosomal snRNP assembly (GO:0000387)3.02595929
74regulation of ligase activity (GO:0051340)3.01924674
75ATP synthesis coupled proton transport (GO:0015986)3.01037676
76energy coupled proton transport, down electrochemical gradient (GO:0015985)3.01037676
77establishment of protein localization to mitochondrial membrane (GO:0090151)2.97465824
78transcription from mitochondrial promoter (GO:0006390)2.96223299
79mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.96137935
80tRNA aminoacylation for protein translation (GO:0006418)2.94964780
81cullin deneddylation (GO:0010388)2.94402314
82regulation of cellular respiration (GO:0043457)2.94247874
83chromatin remodeling at centromere (GO:0031055)2.94022754
84meiotic chromosome segregation (GO:0045132)2.93473553
85kinetochore assembly (GO:0051382)2.93083502
86negative regulation of protein acetylation (GO:1901984)2.91273919
87purine deoxyribonucleotide catabolic process (GO:0009155)2.90771346
88mitochondrial respiratory chain complex assembly (GO:0033108)2.90501574
89rRNA modification (GO:0000154)2.89094383
90chaperone-mediated protein transport (GO:0072321)2.87218427
91arginine metabolic process (GO:0006525)2.86153546
92positive regulation of cell cycle arrest (GO:0071158)2.85832679
93regulation of cellular amine metabolic process (GO:0033238)2.83909368
94DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.82798955
95regulation of mitochondrial translation (GO:0070129)2.82694681
96DNA catabolic process, exonucleolytic (GO:0000738)2.79756570
97mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.77836409
98mitochondrial respiratory chain complex I assembly (GO:0032981)2.77836409
99NADH dehydrogenase complex assembly (GO:0010257)2.77836409
100organelle membrane fusion (GO:0090174)2.76866744

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.45825972
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.05093165
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.00075285
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.94438374
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.93876235
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.79968309
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.65808120
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.37023001
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.11446036
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.99612310
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.77250369
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.64878693
13VDR_22108803_ChIP-Seq_LS180_Human2.60749998
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59161628
15VDR_23849224_ChIP-Seq_CD4+_Human2.58530321
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56462954
17FOXP3_21729870_ChIP-Seq_TREG_Human2.49410974
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.46409700
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.43646237
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41413570
21DCP1A_22483619_ChIP-Seq_HELA_Human2.24746945
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.22503929
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.21091523
24ELK1_19687146_ChIP-ChIP_HELA_Human2.13862427
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09268081
26GABP_19822575_ChIP-Seq_HepG2_Human2.06187173
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.05544199
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04493695
29ZNF274_21170338_ChIP-Seq_K562_Hela2.04297984
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.96909015
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96754484
32XRN2_22483619_ChIP-Seq_HELA_Human1.88693804
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.81901983
34MYC_18940864_ChIP-ChIP_HL60_Human1.77740615
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71135937
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67700783
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65380370
38KDM5A_27292631_Chip-Seq_BREAST_Human1.65230816
39TTF2_22483619_ChIP-Seq_HELA_Human1.65182343
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.59727982
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55615769
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52937467
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50481945
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48797300
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47492273
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43571163
47BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34506048
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29958835
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28758494
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27422936
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26046579
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25519284
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24133550
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.23311520
55NCOR1_26117541_ChIP-Seq_K562_Human1.22413312
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.18716941
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16624452
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14561563
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14258061
60P53_21459846_ChIP-Seq_SAOS-2_Human1.12263759
61TP53_22573176_ChIP-Seq_HFKS_Human1.11791354
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04189571
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04136265
64FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01191818
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.00100691
66ZNF263_19887448_ChIP-Seq_K562_Human0.98931900
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96113232
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95600721
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95034753
70IRF1_19129219_ChIP-ChIP_H3396_Human0.94822574
71GATA1_22025678_ChIP-Seq_K562_Human0.94707123
72LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93052221
73ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92856545
74ELF1_20517297_ChIP-Seq_JURKAT_Human0.92268636
75FLI1_27457419_Chip-Seq_LIVER_Mouse0.91929572
76CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91781248
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91289868
78STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90239582
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89313041
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89176680
81SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86000671
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81051792
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.80687766
84CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.80608386
85FOXP1_21924763_ChIP-Seq_HESCs_Human0.80344765
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80218356
87RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.79644871
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78156159
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78150589
90E2F1_20622854_ChIP-Seq_HELA_Human0.78096561
91ZFX_18555785_ChIP-Seq_MESCs_Mouse0.76193115
92NCOR_22424771_ChIP-Seq_293T_Human0.73045562
93GATA3_26560356_Chip-Seq_TH2_Human0.72922496
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71952462
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.70566946
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.70193209
97EWS_26573619_Chip-Seq_HEK293_Human0.69683105
98NANOG_20526341_ChIP-Seq_ESCs_Human0.69528424
99GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.69500681
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.68421922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence4.37751704
2MP0003786_premature_aging4.03190651
3MP0004147_increased_porphyrin_level3.69119598
4MP0008058_abnormal_DNA_repair3.34892501
5MP0001873_stomach_inflammation3.32315065
6MP0010094_abnormal_chromosome_stability3.17414661
7MP0005083_abnormal_biliary_tract3.17343014
8MP0001529_abnormal_vocalization3.01788948
9MP0003693_abnormal_embryo_hatching2.92357065
10MP0005360_urolithiasis2.87258993
11MP0008875_abnormal_xenobiotic_pharmacok2.76255205
12MP0008872_abnormal_physiological_respon2.62176920
13MP0005646_abnormal_pituitary_gland2.61769619
14MP0003111_abnormal_nucleus_morphology2.60217882
15MP0005167_abnormal_blood-brain_barrier2.24310769
16MP0003656_abnormal_erythrocyte_physiolo2.21851028
17MP0001919_abnormal_reproductive_system2.17192554
18MP0003941_abnormal_skin_development2.16887015
19MP0003718_maternal_effect2.15543280
20MP0002160_abnormal_reproductive_system2.14779822
21MP0008057_abnormal_DNA_replication2.11793373
22MP0004957_abnormal_blastocyst_morpholog2.09496813
23MP0005389_reproductive_system_phenotype2.06088030
24MP0005310_abnormal_salivary_gland1.94378673
25MP0006035_abnormal_mitochondrial_morpho1.79937180
26MP0004142_abnormal_muscle_tone1.61999959
27MP0006036_abnormal_mitochondrial_physio1.61396869
28MP0004019_abnormal_vitamin_homeostasis1.59920672
29MP0000358_abnormal_cell_content/1.56238939
30MP0000685_abnormal_immune_system1.54635415
31MP0009697_abnormal_copulation1.53777855
32MP0005636_abnormal_mineral_homeostasis1.50604292
33MP0002163_abnormal_gland_morphology1.47976804
34MP0003195_calcinosis1.47320996
35MP0009333_abnormal_splenocyte_physiolog1.44568530
36MP0003077_abnormal_cell_cycle1.43838186
37MP0001929_abnormal_gametogenesis1.35078168
38MP0000647_abnormal_sebaceous_gland1.25679474
39MP0000372_irregular_coat_pigmentation1.23930111
40MP0002102_abnormal_ear_morphology1.23387994
41MP0000613_abnormal_salivary_gland1.21513925
42MP0005410_abnormal_fertilization1.21430280
43MP0002210_abnormal_sex_determination1.20259140
44MP0002006_tumorigenesis1.18335154
45MP0005365_abnormal_bile_salt1.13931718
46MP0000427_abnormal_hair_cycle1.12524804
47MP0003936_abnormal_reproductive_system1.12004325
48MP0005671_abnormal_response_to1.10677058
49MP0001881_abnormal_mammary_gland1.10447572
50MP0002396_abnormal_hematopoietic_system1.09170256
51MP0006276_abnormal_autonomic_nervous1.07653495
52MP0006292_abnormal_olfactory_placode1.03919932
53MP0001835_abnormal_antigen_presentation1.00175120
54MP0004145_abnormal_muscle_electrophysio0.98812755
55MP0004947_skin_inflammation0.98692055
56MP0000653_abnormal_sex_gland0.98101091
57MP0002138_abnormal_hepatobiliary_system0.96674877
58MP0001790_abnormal_immune_system0.95705539
59MP0005387_immune_system_phenotype0.95705539
60MP0001984_abnormal_olfaction0.93322934
61MP0008932_abnormal_embryonic_tissue0.92116508
62MP0001119_abnormal_female_reproductive0.90333474
63MP0004133_heterotaxia0.89669667
64MP0006072_abnormal_retinal_apoptosis0.88133268
65MP0005332_abnormal_amino_acid0.86022565
66MP0008877_abnormal_DNA_methylation0.85405127
67MP0004043_abnormal_pH_regulation0.85097195
68MP0005085_abnormal_gallbladder_physiolo0.85084074
69MP0001145_abnormal_male_reproductive0.83893133
70MP0002148_abnormal_hypersensitivity_rea0.83670369
71MP0001764_abnormal_homeostasis0.77855669
72MP0010307_abnormal_tumor_latency0.75181422
73MP0000313_abnormal_cell_death0.74653459
74MP0009785_altered_susceptibility_to0.74193609
75MP0001243_abnormal_dermal_layer0.73576509
76MP0000689_abnormal_spleen_morphology0.73246486
77MP0002166_altered_tumor_susceptibility0.73005568
78MP0002019_abnormal_tumor_incidence0.71833303
79MP0002132_abnormal_respiratory_system0.71486399
80MP0005379_endocrine/exocrine_gland_phen0.69994848
81MP0001348_abnormal_lacrimal_gland0.69704336
82MP0000703_abnormal_thymus_morphology0.69475915
83MP0002928_abnormal_bile_duct0.69314025
84MP0002398_abnormal_bone_marrow0.68525261
85MP0000609_abnormal_liver_physiology0.68292165
86MP0001905_abnormal_dopamine_level0.66848734
87MP0002722_abnormal_immune_system0.65715234
88MP0003698_abnormal_male_reproductive0.65584141
89MP0003699_abnormal_female_reproductive0.65448696
90MP0002429_abnormal_blood_cell0.64963983
91MP0001800_abnormal_humoral_immune0.64355340
92MP0001666_abnormal_nutrient_absorption0.61830128
93MP0000678_abnormal_parathyroid_gland0.60255866
94MP0003646_muscle_fatigue0.59960631
95MP0001663_abnormal_digestive_system0.57954543
96MP0003186_abnormal_redox_activity0.57879117
97MP0001501_abnormal_sleep_pattern0.56714399
98MP0001765_abnormal_ion_homeostasis0.56003529
99MP0008770_decreased_survivor_rate0.55625140
100MP0002693_abnormal_pancreas_physiology0.55423314

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.57171379
2Abnormal mitochondria in muscle tissue (HP:0008316)5.30926912
3Acute encephalopathy (HP:0006846)4.93897590
4Birth length less than 3rd percentile (HP:0003561)4.67714335
5Progressive macrocephaly (HP:0004481)4.49791975
6Mitochondrial inheritance (HP:0001427)4.46618439
7Increased CSF lactate (HP:0002490)4.43027675
8Cerebral edema (HP:0002181)4.20979560
9Hepatocellular necrosis (HP:0001404)3.85545333
10Breech presentation (HP:0001623)3.78890921
11Hepatic necrosis (HP:0002605)3.61217472
12Aplastic anemia (HP:0001915)3.56286480
13Increased hepatocellular lipid droplets (HP:0006565)3.37518323
14Septate vagina (HP:0001153)3.37047341
15Abnormal biliary tract physiology (HP:0012439)3.26754022
16Bile duct proliferation (HP:0001408)3.26754022
17Lipid accumulation in hepatocytes (HP:0006561)3.18621718
18Abnormality of the preputium (HP:0100587)3.04203143
19Seborrheic dermatitis (HP:0001051)3.02035959
20Abnormality of pyrimidine metabolism (HP:0004353)2.81622533
21Concave nail (HP:0001598)2.81285632
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.75346055
23Increased serum lactate (HP:0002151)2.75073411
24Meckel diverticulum (HP:0002245)2.72326162
25Supernumerary spleens (HP:0009799)2.72050588
26Hyperthyroidism (HP:0000836)2.66558646
27Abnormality of the ileum (HP:0001549)2.63728633
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.58921289
29Asplenia (HP:0001746)2.58293886
30Pancreatic fibrosis (HP:0100732)2.54301707
313-Methylglutaconic aciduria (HP:0003535)2.52876452
32Truncus arteriosus (HP:0001660)2.52460939
33Chromsome breakage (HP:0040012)2.50683035
34Pancreatic cysts (HP:0001737)2.49895018
35Duplicated collecting system (HP:0000081)2.49685652
36Aplasia/Hypoplasia of the spleen (HP:0010451)2.42930659
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.39884288
38Exercise intolerance (HP:0003546)2.39570085
39Increased intramyocellular lipid droplets (HP:0012240)2.36483181
40Lactic acidosis (HP:0003128)2.36447338
41Abnormality of the pons (HP:0007361)2.35970975
42Respiratory failure (HP:0002878)2.30412590
43Aplasia/Hypoplasia of the earlobes (HP:0009906)2.30311200
44Single umbilical artery (HP:0001195)2.29749230
45Abnormality of the fetal cardiovascular system (HP:0010948)2.29749230
46Abnormal umbilical cord blood vessels (HP:0011403)2.29749230
47Poor suck (HP:0002033)2.28005257
48Optic disc pallor (HP:0000543)2.26473574
49Abnormal number of erythroid precursors (HP:0012131)2.24505564
50Esophageal neoplasm (HP:0100751)2.23182181
51Neoplasm of head and neck (HP:0012288)2.23182181
52Abnormality of the renal collecting system (HP:0004742)2.22728703
53Exertional dyspnea (HP:0002875)2.18589317
54IgG deficiency (HP:0004315)2.16916219
55Generalized aminoaciduria (HP:0002909)2.16802018
56Pancytopenia (HP:0001876)2.15586457
57Hypoplasia of the pons (HP:0012110)2.13573466
58Abnormality of the carotid arteries (HP:0005344)2.11916939
59Abnormal gallbladder physiology (HP:0012438)2.10925926
60Cholecystitis (HP:0001082)2.10925926
61Sclerocornea (HP:0000647)2.10274383
62Leukodystrophy (HP:0002415)2.09797176
63Lethargy (HP:0001254)2.09410709
64True hermaphroditism (HP:0010459)2.09302117
65Breast hypoplasia (HP:0003187)2.05002654
66Hypertensive crisis (HP:0100735)2.04478627
67Dry hair (HP:0011359)2.03888399
68Premature skin wrinkling (HP:0100678)2.03534518
69Duodenal stenosis (HP:0100867)2.01680250
70Small intestinal stenosis (HP:0012848)2.01680250
71Abnormality of chromosome stability (HP:0003220)2.01198283
72Renal Fanconi syndrome (HP:0001994)2.00528081
73Aplasia/Hypoplasia of the patella (HP:0006498)1.98369855
74Respiratory difficulties (HP:0002880)1.96963605
75Increased muscle lipid content (HP:0009058)1.96404268
76Clubbing of toes (HP:0100760)1.95778143
77Cerebral hypomyelination (HP:0006808)1.94955383
78Type II lissencephaly (HP:0007260)1.94889798
79Patellar aplasia (HP:0006443)1.90654926
80Abnormality of DNA repair (HP:0003254)1.90587262
81Progressive microcephaly (HP:0000253)1.86195548
82Self-mutilation (HP:0000742)1.85107535
83Abnormality of the tricuspid valve (HP:0001702)1.84226792
84CNS demyelination (HP:0007305)1.80784825
85Horseshoe kidney (HP:0000085)1.80209522
86Aplasia/Hypoplasia of the tongue (HP:0010295)1.79883688
87Abnormality of the labia minora (HP:0012880)1.79473147
88Blindness (HP:0000618)1.75621389
89Emotional lability (HP:0000712)1.75235751
90Vomiting (HP:0002013)1.74532905
91Decreased activity of mitochondrial respiratory chain (HP:0008972)1.74199725
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.74199725
93Severe combined immunodeficiency (HP:0004430)1.73985507
94Increased serum pyruvate (HP:0003542)1.73440431
95Large for gestational age (HP:0001520)1.72808115
96Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.72621477
97Stomatitis (HP:0010280)1.69244337
98Abnormality of cochlea (HP:0000375)1.69080571
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67808428
100Hyperalaninemia (HP:0003348)1.67808428

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK45.74410825
2MAP4K23.91138007
3EIF2AK13.01395648
4NME12.89188435
5TSSK62.81749540
6PBK2.80494902
7MST42.65559247
8SRPK12.47715342
9PLK22.47108304
10EIF2AK32.46541466
11VRK22.15768584
12BUB12.08922899
13ADRBK21.99070042
14TLK11.89382697
15ZAK1.86733800
16BCKDK1.83104164
17MAP3K121.82635272
18WNK41.82182263
19TRIM281.81997725
20CLK11.55995073
21NUAK11.53704205
22CDC71.51643921
23KDR1.44242321
24CDK81.42425337
25PDK21.39860291
26MAPKAPK31.37849231
27TAOK31.34404146
28CHEK21.33458375
29ALK1.22075588
30DAPK11.22002203
31ATR1.21165569
32OXSR11.12312091
33BMPR1B1.11716294
34GRK11.11155618
35NME21.10894002
36TTK1.09813979
37VRK11.08997488
38ACVR1B1.08179575
39MAP3K110.98656249
40EIF2AK20.97757328
41NEK10.95741658
42PLK30.93668461
43PLK10.90940780
44PASK0.87270497
45TGFBR10.85686579
46STK40.84916675
47TNK20.79849121
48MAP2K60.78251416
49PINK10.76391538
50STK390.75758748
51MAP3K40.75684145
52BRSK10.74919441
53RPS6KA50.74805910
54RIPK40.70104588
55WNK30.69246148
56CDK30.65651274
57CSNK2A10.64743240
58MATK0.59054440
59CSNK2A20.58099055
60AURKA0.57040181
61BRSK20.53837111
62PIM10.51080649
63WEE10.49976917
64GRK50.49860645
65IKBKB0.49805623
66CSNK1G30.49559160
67ATM0.48636512
68PIK3CG0.48044454
69CDK40.47111926
70GRK60.46805871
71MYLK0.44416055
72FLT30.44409538
73MAPK120.42500072
74TEC0.41620423
75CSNK1A1L0.41069213
76MAP2K40.40018245
77BMX0.37760015
78CHEK10.37467051
79CSNK1A10.37025475
80ADRBK10.36938239
81PAK10.36599746
82PRKCI0.36506898
83MAP3K80.35964161
84NTRK10.34717655
85MAP2K70.34626646
86MARK30.33727882
87MAPK130.33666809
88MKNK10.33570391
89NEK20.32491074
90STK160.30880234
91MAP2K20.29375657
92PHKG20.28901373
93PHKG10.28901373
94CDK10.28451180
95CDK70.28243278
96KSR20.28099482
97AURKB0.26455098
98TIE10.26446098
99CAMK10.26025397
100FES0.25572512

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.83938739
2Oxidative phosphorylation_Homo sapiens_hsa001903.14092440
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.99870970
4Fanconi anemia pathway_Homo sapiens_hsa034602.99237104
5Homologous recombination_Homo sapiens_hsa034402.98415441
6DNA replication_Homo sapiens_hsa030302.94858735
7RNA polymerase_Homo sapiens_hsa030202.85098449
8Mismatch repair_Homo sapiens_hsa034302.84681618
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.81365426
10One carbon pool by folate_Homo sapiens_hsa006702.57026502
11Base excision repair_Homo sapiens_hsa034102.54542951
12Parkinsons disease_Homo sapiens_hsa050122.33277692
13Non-homologous end-joining_Homo sapiens_hsa034502.29826715
14Basal transcription factors_Homo sapiens_hsa030222.17838079
15Ribosome_Homo sapiens_hsa030102.14861489
16Protein export_Homo sapiens_hsa030602.07399833
17Spliceosome_Homo sapiens_hsa030402.01167390
18Nucleotide excision repair_Homo sapiens_hsa034201.89664891
19RNA transport_Homo sapiens_hsa030131.85717376
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71553493
21Steroid biosynthesis_Homo sapiens_hsa001001.71278730
22Asthma_Homo sapiens_hsa053101.70913601
23Huntingtons disease_Homo sapiens_hsa050161.64281777
24Arginine biosynthesis_Homo sapiens_hsa002201.62957632
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.60237074
26Pyruvate metabolism_Homo sapiens_hsa006201.57517550
27RNA degradation_Homo sapiens_hsa030181.53048136
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43134032
29Propanoate metabolism_Homo sapiens_hsa006401.35797881
30Pyrimidine metabolism_Homo sapiens_hsa002401.34448631
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.29043203
32Alzheimers disease_Homo sapiens_hsa050101.28951397
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.26492025
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19845205
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.17812295
36Primary immunodeficiency_Homo sapiens_hsa053401.17191747
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15966583
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.15501860
39Collecting duct acid secretion_Homo sapiens_hsa049661.04416207
40Olfactory transduction_Homo sapiens_hsa047401.03633760
41Allograft rejection_Homo sapiens_hsa053300.99345232
42Autoimmune thyroid disease_Homo sapiens_hsa053200.95957886
43Purine metabolism_Homo sapiens_hsa002300.94980071
44Cell cycle_Homo sapiens_hsa041100.90036811
45Selenocompound metabolism_Homo sapiens_hsa004500.86458283
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84247144
47Glutathione metabolism_Homo sapiens_hsa004800.83181579
48Biosynthesis of amino acids_Homo sapiens_hsa012300.81552203
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80473397
50Nitrogen metabolism_Homo sapiens_hsa009100.78684451
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78104023
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73961423
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.73854347
54mRNA surveillance pathway_Homo sapiens_hsa030150.72236123
55Caffeine metabolism_Homo sapiens_hsa002320.70573882
56Metabolic pathways_Homo sapiens_hsa011000.68601435
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66740753
58Carbon metabolism_Homo sapiens_hsa012000.63812672
59Mineral absorption_Homo sapiens_hsa049780.62393109
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61148670
61Cardiac muscle contraction_Homo sapiens_hsa042600.57293009
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56896105
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.55361450
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53885144
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53393583
66Butanoate metabolism_Homo sapiens_hsa006500.48958668
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48905965
68Retinol metabolism_Homo sapiens_hsa008300.48394434
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47785618
70Fat digestion and absorption_Homo sapiens_hsa049750.44852544
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43118014
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42546123
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41937370
74Rheumatoid arthritis_Homo sapiens_hsa053230.40720168
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.39991148
76Fructose and mannose metabolism_Homo sapiens_hsa000510.39327294
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39188392
78Fatty acid elongation_Homo sapiens_hsa000620.38498221
79Vitamin B6 metabolism_Homo sapiens_hsa007500.37964620
80Epstein-Barr virus infection_Homo sapiens_hsa051690.35212930
81Chemical carcinogenesis_Homo sapiens_hsa052040.34367585
82Hematopoietic cell lineage_Homo sapiens_hsa046400.34126744
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.33213836
84Antigen processing and presentation_Homo sapiens_hsa046120.32798042
85Phototransduction_Homo sapiens_hsa047440.31190593
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.30220845
87Linoleic acid metabolism_Homo sapiens_hsa005910.26737804
88Herpes simplex infection_Homo sapiens_hsa051680.25211559
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24175835
90Type I diabetes mellitus_Homo sapiens_hsa049400.23794697
91T cell receptor signaling pathway_Homo sapiens_hsa046600.22603140
92Tryptophan metabolism_Homo sapiens_hsa003800.19093762
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18584477
94Fatty acid metabolism_Homo sapiens_hsa012120.18396577
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.18039328
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17902277
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17436611
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17158859
99Taste transduction_Homo sapiens_hsa047420.16679175
100Systemic lupus erythematosus_Homo sapiens_hsa053220.16284908

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