ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore complex assembly (GO:0051292)	7.19471631
2	nuclear pore organization (GO:0006999)	6.32560886
3	pore complex assembly (GO:0046931)	5.55910700
4	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	5.17580430
5	nonmotile primary cilium assembly (GO:0035058)	4.69245179
6	regulation of centriole replication (GO:0046599)	4.68344294
7	DNA strand elongation (GO:0022616)	4.43559011
8	DNA strand elongation involved in DNA replication (GO:0006271)	4.43533651
9	mitotic sister chromatid cohesion (GO:0007064)	4.35478910
10	telomere maintenance via semi-conservative replication (GO:0032201)	4.31613175
11	telomere maintenance via recombination (GO:0000722)	4.07848417
12	regulation of cilium movement (GO:0003352)	4.05197391
13	chromatin remodeling at centromere (GO:0031055)	3.98475771
14	striatum development (GO:0021756)	3.96835838
15	mitochondrial fission (GO:0000266)	3.95085409
16	mitotic recombination (GO:0006312)	3.94653499
17	positive regulation of developmental pigmentation (GO:0048087)	3.93851230
18	CENP-A containing nucleosome assembly (GO:0034080)	3.80586988
19	DNA synthesis involved in DNA repair (GO:0000731)	3.77817674
20	DNA double-strand break processing (GO:0000729)	3.72034759
21	negative regulation of response to food (GO:0032096)	3.64072096
22	negative regulation of appetite (GO:0032099)	3.64072096
23	mitotic chromosome condensation (GO:0007076)	3.63988079
24	DNA replication-dependent nucleosome assembly (GO:0006335)	3.59087230
25	DNA replication-dependent nucleosome organization (GO:0034723)	3.59087230
26	DNA replication initiation (GO:0006270)	3.58942947
27	brain morphogenesis (GO:0048854)	3.57988826
28	mitotic nuclear envelope disassembly (GO:0007077)	3.55156988
29	DNA replication checkpoint (GO:0000076)	3.51978219
30	positive regulation of histone H3-K4 methylation (GO:0051571)	3.50016595
31	non-recombinational repair (GO:0000726)	3.49568458
32	double-strand break repair via nonhomologous end joining (GO:0006303)	3.49568458
33	double-strand break repair via homologous recombination (GO:0000724)	3.49383326
34	cellular response to leptin stimulus (GO:0044320)	3.43507163
35	recombinational repair (GO:0000725)	3.42006343
36	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.39002308
37	nuclear envelope disassembly (GO:0051081)	3.38303298
38	membrane disassembly (GO:0030397)	3.38303298
39	regulation of translational termination (GO:0006449)	3.37573182
40	regulation of mitotic spindle organization (GO:0060236)	3.37451575
41	regulation of centrosome duplication (GO:0010824)	3.35656272
42	telomere maintenance (GO:0000723)	3.35189024
43	protein K6-linked ubiquitination (GO:0085020)	3.35139049
44	mitotic sister chromatid segregation (GO:0000070)	3.32134903
45	signal peptide processing (GO:0006465)	3.31466819
46	telomere organization (GO:0032200)	3.30776691
47	interkinetic nuclear migration (GO:0022027)	3.29152930
48	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.27319822
49	regulation of centrosome cycle (GO:0046605)	3.25454846
50	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.24990018
51	regulation of mitotic spindle checkpoint (GO:1903504)	3.24990018
52	snRNA transcription (GO:0009301)	3.23109556
53	positive regulation of cardiac muscle tissue growth (GO:0055023)	3.21868924
54	DNA duplex unwinding (GO:0032508)	3.19321730
55	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.17837922
56	DNA geometric change (GO:0032392)	3.16771129
57	protein prenylation (GO:0018342)	3.16559463
58	prenylation (GO:0097354)	3.16559463
59	DNA unwinding involved in DNA replication (GO:0006268)	3.15008578
60	telomere maintenance via telomere lengthening (GO:0010833)	3.12121898
61	histone exchange (GO:0043486)	3.10660298
62	sister chromatid segregation (GO:0000819)	3.09162848
63	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.08401577
64	negative regulation of execution phase of apoptosis (GO:1900118)	3.07019688
65	postreplication repair (GO:0006301)	3.02157294
66	positive regulation of histone methylation (GO:0031062)	3.02139161
67	replication fork processing (GO:0031297)	2.98087337
68	negative regulation of DNA recombination (GO:0045910)	2.95697437
69	endosome to melanosome transport (GO:0035646)	2.95463105
70	endosome to pigment granule transport (GO:0043485)	2.95463105
71	regulation of histone H3-K9 methylation (GO:0051570)	2.95388101
72	regulation of spindle organization (GO:0090224)	2.94887820
73	double-strand break repair (GO:0006302)	2.94415095
74	centrosome organization (GO:0051297)	2.93762921
75	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.93272125
76	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.93272125
77	DNA replication-independent nucleosome assembly (GO:0006336)	2.93051893
78	DNA replication-independent nucleosome organization (GO:0034724)	2.93051893
79	positive regulation of cardiac muscle cell proliferation (GO:0060045)	2.92016218
80	positive regulation of cell cycle checkpoint (GO:1901978)	2.90999631
81	fibroblast migration (GO:0010761)	2.90123142
82	regulation of helicase activity (GO:0051095)	2.88479938
83	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.87900632
84	regulation of pigment cell differentiation (GO:0050932)	2.87518628
85	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.87494523
86	RNA polyadenylation (GO:0043631)	2.87231283
87	pericardium development (GO:0060039)	2.86830491
88	regulation of hippo signaling (GO:0035330)	2.86604232
89	metaphase plate congression (GO:0051310)	2.84986520
90	response to leptin (GO:0044321)	2.84460504
91	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.83651119
92	corticosteroid receptor signaling pathway (GO:0031958)	2.83555301
93	microtubule organizing center organization (GO:0031023)	2.81987381
94	positive regulation of heart growth (GO:0060421)	2.76718810
95	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.76352599
96	isotype switching (GO:0045190)	2.76352599
97	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.76352599
98	negative regulation of protein localization to cell surface (GO:2000009)	2.75475461
99	DNA-dependent DNA replication (GO:0006261)	2.73796120
100	replicative senescence (GO:0090399)	2.73762634

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	8.40422487
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.52524492
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.47596464
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.41715690
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.94097489
6	GATA1_22025678_ChIP-Seq_K562_Human	2.89533998
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.73844427
8	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.71190997
9	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.69628431
10	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.56882913
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.35422039
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.30774844
13	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.27913842
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.23237891
15	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.19837390
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.18269035
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.08259810
18	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.02707326
19	ZNF274_21170338_ChIP-Seq_K562_Hela	2.02109033
20	FUS_26573619_Chip-Seq_HEK293_Human	1.97672439
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.96287037
22	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.95629018
23	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.94702486
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.91713733
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.86870351
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.80251883
27	EWS_26573619_Chip-Seq_HEK293_Human	1.71153012
28	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.66192756
29	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.63518030
30	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.63327389
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.61111344
32	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.57716468
33	IGF1R_20145208_ChIP-Seq_DFB_Human	1.56039743
34	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.55827471
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.55520608
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.55184894
37	STAT3_23295773_ChIP-Seq_U87_Human	1.53733159
38	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.41015220
39	VDR_23849224_ChIP-Seq_CD4+_Human	1.36617379
40	TAF15_26573619_Chip-Seq_HEK293_Human	1.34415504
41	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.33788680
42	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.32992271
43	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.30722906
44	TCF4_23295773_ChIP-Seq_U87_Human	1.29376317
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.28405580
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.26516225
47	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.25748566
48	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.24031068
49	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.22208508
50	BCAT_22108803_ChIP-Seq_LS180_Human	1.20429739
51	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.20011005
52	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.17181739
53	KDM5A_27292631_Chip-Seq_BREAST_Human	1.16514838
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.15550849
55	SMAD4_21799915_ChIP-Seq_A2780_Human	1.14758779
56	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.14487661
57	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.13509107
58	P300_19829295_ChIP-Seq_ESCs_Human	1.12234397
59	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11978593
60	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.11194189
61	CBP_20019798_ChIP-Seq_JUKART_Human	1.11194189
62	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.10908901
63	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.10736493
64	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.08640893
65	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08640893
66	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.08575414
67	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.07829304
68	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06896199
69	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.03684503
70	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02720646
71	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.02628635
72	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.99936118
73	AR_25329375_ChIP-Seq_VCAP_Human	0.99803670
74	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.99699584
75	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99584349
76	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.98485048
77	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.98466360
78	DCP1A_22483619_ChIP-Seq_HELA_Human	0.97931613
79	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.95770587
80	FOXP3_21729870_ChIP-Seq_TREG_Human	0.94539159
81	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.94256427
82	MYC_18940864_ChIP-ChIP_HL60_Human	0.94241341
83	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.94140453
84	P53_22387025_ChIP-Seq_ESCs_Mouse	0.93937689
85	VDR_22108803_ChIP-Seq_LS180_Human	0.93767245
86	P300_18555785_Chip-Seq_ESCs_Mouse	0.93432643
87	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.92741611
88	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.91127865
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.89954367
90	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.88566831
91	SOX9_26525672_Chip-Seq_HEART_Mouse	0.88258971
92	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.88215328
93	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.87595863
94	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.86622760
95	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.86346352
96	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.84685993
97	AR_21909140_ChIP-Seq_LNCAP_Human	0.83868708
98	TFEB_21752829_ChIP-Seq_HELA_Human	0.82431377
99	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.81866738
100	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.81844460

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	5.85835661
2	MP0000569_abnormal_digit_pigmentation	4.58276191
3	MP0010094_abnormal_chromosome_stability	4.07517580
4	MP0001984_abnormal_olfaction	3.89842754
5	MP0008058_abnormal_DNA_repair	3.07469138
6	MP0003111_abnormal_nucleus_morphology	2.73161592
7	MP0003890_abnormal_embryonic-extraembry	2.59210165
8	MP0001529_abnormal_vocalization	2.55660337
9	MP0002734_abnormal_mechanical_nocicepti	2.38450783
10	MP0003077_abnormal_cell_cycle	2.23548616
11	MP0010307_abnormal_tumor_latency	2.15434835
12	MP0005408_hypopigmentation	1.86607318
13	MP0005083_abnormal_biliary_tract	1.84875444
14	MP0002822_catalepsy	1.84663154
15	MP0009697_abnormal_copulation	1.84242998
16	MP0000427_abnormal_hair_cycle	1.82197128
17	MP0000647_abnormal_sebaceous_gland	1.69762701
18	MP0005310_abnormal_salivary_gland	1.64765053
19	MP0008932_abnormal_embryonic_tissue	1.63055227
20	MP0002396_abnormal_hematopoietic_system	1.58206531
21	MP0010352_gastrointestinal_tract_polyps	1.55673013
22	MP0003950_abnormal_plasma_membrane	1.55004784
23	MP0000372_irregular_coat_pigmentation	1.50416763
24	MP0002736_abnormal_nociception_after	1.46387197
25	MP0003693_abnormal_embryo_hatching	1.41591924
26	MP0002160_abnormal_reproductive_system	1.37318315
27	MP0003718_maternal_effect	1.37057155
28	MP0001929_abnormal_gametogenesis	1.36137781
29	MP0005645_abnormal_hypothalamus_physiol	1.35837049
30	MP0008007_abnormal_cellular_replicative	1.32864778
31	MP0003786_premature_aging	1.31409736
32	MP0004957_abnormal_blastocyst_morpholog	1.31099164
33	MP0006035_abnormal_mitochondrial_morpho	1.27406748
34	MP0002009_preneoplasia	1.27111297
35	MP0000015_abnormal_ear_pigmentation	1.25928855
36	MP0005085_abnormal_gallbladder_physiolo	1.25064977
37	MP0001968_abnormal_touch/_nociception	1.23441157
38	MP0005423_abnormal_somatic_nervous	1.21007072
39	MP0005551_abnormal_eye_electrophysiolog	1.16263762
40	MP0005187_abnormal_penis_morphology	1.15327082
41	MP0006054_spinal_hemorrhage	1.11657349
42	MP0005499_abnormal_olfactory_system	1.11268252
43	MP0005394_taste/olfaction_phenotype	1.11268252
44	MP0002254_reproductive_system_inflammat	1.05448181
45	MP0004215_abnormal_myocardial_fiber	1.05296396
46	MP0010386_abnormal_urinary_bladder	1.03221383
47	MP0002102_abnormal_ear_morphology	1.03139102
48	MP0005248_abnormal_Harderian_gland	1.03019904
49	MP0008872_abnormal_physiological_respon	1.02611859
50	MP0002269_muscular_atrophy	1.02400829
51	MP0003632_abnormal_nervous_system	1.01959141
52	MP0008877_abnormal_DNA_methylation	1.00495454
53	MP0002210_abnormal_sex_determination	0.98642210
54	MP0009703_decreased_birth_body	0.97903995
55	MP0003698_abnormal_male_reproductive	0.97886708
56	MP0005253_abnormal_eye_physiology	0.97440450
57	MP0000538_abnormal_urinary_bladder	0.95825460
58	MP0002837_dystrophic_cardiac_calcinosis	0.94131868
59	MP0001919_abnormal_reproductive_system	0.93432058
60	MP0004924_abnormal_behavior	0.93079309
61	MP0005386_behavior/neurological_phenoty	0.93079309
62	MP0000358_abnormal_cell_content/	0.92073530
63	MP0001672_abnormal_embryogenesis/_devel	0.91892904
64	MP0005380_embryogenesis_phenotype	0.91892904
65	MP0008770_decreased_survivor_rate	0.91542965
66	MP0005266_abnormal_metabolism	0.90904768
67	MP0005389_reproductive_system_phenotype	0.89507520
68	MP0003984_embryonic_growth_retardation	0.88510617
69	MP0004808_abnormal_hematopoietic_stem	0.87169789
70	MP0000653_abnormal_sex_gland	0.85844723
71	MP0008789_abnormal_olfactory_epithelium	0.85267137
72	MP0002088_abnormal_embryonic_growth/wei	0.84930876
73	MP0001145_abnormal_male_reproductive	0.83901088
74	MP0002095_abnormal_skin_pigmentation	0.83426228
75	MP0001970_abnormal_pain_threshold	0.83002608
76	MP0003646_muscle_fatigue	0.82609878
77	MP0000350_abnormal_cell_proliferation	0.82019390
78	MP0002272_abnormal_nervous_system	0.78533751
79	MP0005171_absent_coat_pigmentation	0.76913058
80	MP0003699_abnormal_female_reproductive	0.76519084
81	MP0003221_abnormal_cardiomyocyte_apopto	0.75820315
82	MP0003936_abnormal_reproductive_system	0.75347625
83	MP0004147_increased_porphyrin_level	0.75105241
84	MP0002080_prenatal_lethality	0.74215392
85	MP0005076_abnormal_cell_differentiation	0.74094025
86	MP0001119_abnormal_female_reproductive	0.73334804
87	MP0001730_embryonic_growth_arrest	0.72658016
88	MP0003329_amyloid_beta_deposits	0.72626086
89	MP0002938_white_spotting	0.72203468
90	MP0002332_abnormal_exercise_endurance	0.70989930
91	MP0006072_abnormal_retinal_apoptosis	0.70657212
92	MP0002184_abnormal_innervation	0.69379179
93	MP0009046_muscle_twitch	0.68129363
94	MP0005367_renal/urinary_system_phenotyp	0.67700527
95	MP0000516_abnormal_urinary_system	0.67700527
96	MP0001661_extended_life_span	0.66740178
97	MP0002161_abnormal_fertility/fecundity	0.66380927
98	MP0008961_abnormal_basal_metabolism	0.66313989
99	MP0010329_abnormal_lipoprotein_level	0.65156595
100	MP0000371_diluted_coat_color	0.64609012

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Progressive inability to walk (HP:0002505)	6.25280594
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	5.27408439
3	Chromsome breakage (HP:0040012)	4.95197421
4	Birth length less than 3rd percentile (HP:0003561)	4.83260789
5	Abnormality of chromosome stability (HP:0003220)	4.09946014
6	Intestinal atresia (HP:0011100)	3.78311927
7	Medial flaring of the eyebrow (HP:0010747)	3.47267239
8	Congenital primary aphakia (HP:0007707)	3.44744104
9	Oligodactyly (hands) (HP:0001180)	3.42423634
10	Gait imbalance (HP:0002141)	3.34546814
11	Inability to walk (HP:0002540)	3.24873727
12	Volvulus (HP:0002580)	3.13711406
13	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.04607856
14	Fair hair (HP:0002286)	3.03639833
15	Poor coordination (HP:0002370)	2.92870922
16	Nephrogenic diabetes insipidus (HP:0009806)	2.92241826
17	Chin dimple (HP:0010751)	2.90555661
18	Abnormality of the ileum (HP:0001549)	2.88241642
19	Submucous cleft hard palate (HP:0000176)	2.87923955
20	Long clavicles (HP:0000890)	2.86392871
21	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.82774391
22	Abnormality of alanine metabolism (HP:0010916)	2.82774391
23	Hyperalaninemia (HP:0003348)	2.82774391
24	Meckel diverticulum (HP:0002245)	2.76482176
25	Delayed puberty (HP:0000823)	2.76015660
26	Pancreatic cysts (HP:0001737)	2.72513211
27	Clubbing of toes (HP:0100760)	2.72270889
28	Absent radius (HP:0003974)	2.71237943
29	Deep palmar crease (HP:0006191)	2.67186873
30	Hypoplastic nipples (HP:0002557)	2.63397549
31	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.63153099
32	Vaginal atresia (HP:0000148)	2.51791933
33	Aplasia involving forearm bones (HP:0009822)	2.47608128
34	Absent forearm bone (HP:0003953)	2.47608128
35	Abnormality of the parathyroid morphology (HP:0011766)	2.45333076
36	Astigmatism (HP:0000483)	2.45249133
37	Sloping forehead (HP:0000340)	2.44002596
38	Large for gestational age (HP:0001520)	2.43439919
39	Abnormality of the preputium (HP:0100587)	2.42018617
40	Genital tract atresia (HP:0001827)	2.38903827
41	Abnormality of the duodenum (HP:0002246)	2.37063349
42	Esophageal atresia (HP:0002032)	2.31066833
43	Overlapping toe (HP:0001845)	2.24739932
44	Abnormality of the carotid arteries (HP:0005344)	2.23799458
45	Generalized hypopigmentation of hair (HP:0011358)	2.22816767
46	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.21539767
47	Hypoplasia of the fovea (HP:0007750)	2.21539767
48	Microtia (HP:0008551)	2.21127554
49	Acute myeloid leukemia (HP:0004808)	2.18148494
50	Deep philtrum (HP:0002002)	2.13083841
51	Ectopic kidney (HP:0000086)	2.12458080
52	Sandal gap (HP:0001852)	2.11397563
53	Clitoromegaly (HP:0000057)	2.10938238
54	Lissencephaly (HP:0001339)	2.10837879
55	Duodenal stenosis (HP:0100867)	2.09872003
56	Small intestinal stenosis (HP:0012848)	2.09872003
57	Broad foot (HP:0001769)	2.09423125
58	Aqueductal stenosis (HP:0002410)	2.03460427
59	Anteriorly placed anus (HP:0001545)	1.97394682
60	Septate vagina (HP:0001153)	1.96980728
61	Labial hypoplasia (HP:0000066)	1.95636799
62	Abnormality of DNA repair (HP:0003254)	1.94995905
63	Patellar aplasia (HP:0006443)	1.94709871
64	Myelodysplasia (HP:0002863)	1.93717552
65	Oligodactyly (HP:0012165)	1.92583807
66	Prominent nose (HP:0000448)	1.90720369
67	Thyroid carcinoma (HP:0002890)	1.90030534
68	Obsessive-compulsive behavior (HP:0000722)	1.88483729
69	True hermaphroditism (HP:0010459)	1.88357739
70	IgA deficiency (HP:0002720)	1.87052143
71	Hypoplastic female external genitalia (HP:0012815)	1.84973442
72	Heterotopia (HP:0002282)	1.84445611
73	Decreased lacrimation (HP:0000633)	1.84073604
74	Anal atresia (HP:0002023)	1.83042945
75	Anal stenosis (HP:0002025)	1.79330040
76	Menstrual irregularities (HP:0000858)	1.79283966
77	Oculomotor apraxia (HP:0000657)	1.78506882
78	Abnormality of the astrocytes (HP:0100707)	1.78424830
79	Astrocytoma (HP:0009592)	1.78424830
80	Duplicated collecting system (HP:0000081)	1.78234411
81	Hypobetalipoproteinemia (HP:0003563)	1.77706555
82	Gastrointestinal atresia (HP:0002589)	1.77641265
83	Attenuation of retinal blood vessels (HP:0007843)	1.76351894
84	Large eyes (HP:0001090)	1.76027260
85	Prominent nasal bridge (HP:0000426)	1.75585549
86	Glioma (HP:0009733)	1.75316842
87	Abnormality of cochlea (HP:0000375)	1.75226688
88	Anencephaly (HP:0002323)	1.74161550
89	Pancreatic fibrosis (HP:0100732)	1.74111831
90	Cerebellar dysplasia (HP:0007033)	1.73405120
91	Micropenis (HP:0000054)	1.72190226
92	High pitched voice (HP:0001620)	1.71068238
93	Neoplasm of the oral cavity (HP:0100649)	1.70871693
94	Double outlet right ventricle (HP:0001719)	1.70862079
95	Congenital malformation of the right heart (HP:0011723)	1.70862079
96	Cafe-au-lait spot (HP:0000957)	1.70636652
97	Hyperventilation (HP:0002883)	1.70256287
98	Breast carcinoma (HP:0003002)	1.70200718
99	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.69359460
100	Abnormality of the fovea (HP:0000493)	1.69147333

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERBB4	6.53922775
2	FRK	4.52763030
3	PDK2	4.49325772
4	AKT3	4.32906188
5	EIF2AK1	3.60146650
6	EIF2AK3	3.14453696
7	ACVR1B	2.74615540
8	MAP3K4	2.28900031
9	CDC7	2.18633819
10	PBK	2.07085980
11	TNIK	2.02708760
12	ZAK	2.01807543
13	SGK2	1.99292950
14	DYRK3	1.83235842
15	WEE1	1.78608515
16	MKNK2	1.76913298
17	TTK	1.74714322
18	RPS6KA4	1.55613628
19	BRSK2	1.44185338
20	SRPK1	1.41898767
21	MST4	1.34282631
22	CLK1	1.27235157
23	SGK3	1.24956818
24	TSSK6	1.20142809
25	BUB1	1.19046459
26	BMPR1B	1.16183767
27	SGK223	1.12391984
28	SGK494	1.12391984
29	ATR	1.05904965
30	PLK1	1.05209596
31	ATM	0.99153600
32	MAPK11	0.94454989
33	NME1	0.94067895
34	MELK	0.93187783
35	RPS6KA5	0.92061460
36	BRD4	0.92026061
37	PLK4	0.91873755
38	GRK1	0.91435795
39	PNCK	0.89993649
40	EIF2AK2	0.89896786
41	NEK6	0.87798950
42	MKNK1	0.87605774
43	CASK	0.86222705
44	TGFBR1	0.85883433
45	PLK3	0.84116996
46	CDK12	0.80413700
47	STK16	0.78319525
48	CHEK1	0.75211745
49	CDK9	0.74534041
50	NEK2	0.73030142
51	NLK	0.70172584
52	VRK1	0.69807526
53	WNK3	0.69361023
54	AURKB	0.68611485
55	CCNB1	0.67102991
56	STK4	0.66245887
57	TLK1	0.66048207
58	CHEK2	0.63607356
59	CAMK1G	0.57512789
60	INSRR	0.57140482
61	MAP4K2	0.54340925
62	PRKD3	0.52491495
63	NUAK1	0.50354034
64	PRKDC	0.50079960
65	CAMK1D	0.49858936
66	MAP3K8	0.47767741
67	CSNK1G1	0.47333545
68	OBSCN	0.46850541
69	CSNK1A1L	0.43021254
70	PLK2	0.42649977
71	PRKCE	0.42413169
72	SGK1	0.40243295
73	BMPR2	0.39652640
74	MAP2K7	0.37979531
75	STK38L	0.37176178
76	BRAF	0.36448951
77	NEK1	0.34738301
78	FGFR1	0.34012043
79	TAF1	0.33141913
80	IKBKE	0.31983640
81	PRKCB	0.31186476
82	PIM1	0.31049027
83	RAF1	0.30731725
84	PASK	0.30157604
85	CDK7	0.29677271
86	PRKCI	0.28221482
87	RPS6KB1	0.27995057
88	CAMK2D	0.27974634
89	CDK1	0.27078705
90	PRKG1	0.26270841
91	PAK3	0.26238057
92	CDK2	0.25899471
93	PRKCG	0.24207079
94	CSNK1E	0.22194194
95	PRKACB	0.20735366
96	CAMK4	0.20571573
97	TRPM7	0.19948025
98	NTRK3	0.19241149
99	EGFR	0.18812952
100	CSNK2A1	0.18764435

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	4.27625385
2	Mismatch repair_Homo sapiens_hsa03430	3.88086410
3	Homologous recombination_Homo sapiens_hsa03440	3.55594135
4	Non-homologous end-joining_Homo sapiens_hsa03450	3.06950879
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.99991443
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.68955958
7	One carbon pool by folate_Homo sapiens_hsa00670	2.64078286
8	Nucleotide excision repair_Homo sapiens_hsa03420	2.56378201
9	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.54832078
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.48119998
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.30666446
12	Lysine degradation_Homo sapiens_hsa00310	2.24061708
13	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.16002958
14	Propanoate metabolism_Homo sapiens_hsa00640	2.07306524
15	Cell cycle_Homo sapiens_hsa04110	2.03960016
16	Nicotine addiction_Homo sapiens_hsa05033	2.00813326
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.90720648
18	Alcoholism_Homo sapiens_hsa05034	1.89887165
19	Base excision repair_Homo sapiens_hsa03410	1.81644389
20	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.67246212
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.64697695
22	Fatty acid metabolism_Homo sapiens_hsa01212	1.64003146
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.62223535
24	mRNA surveillance pathway_Homo sapiens_hsa03015	1.48956273
25	Basal transcription factors_Homo sapiens_hsa03022	1.47441117
26	Pyruvate metabolism_Homo sapiens_hsa00620	1.42692149
27	RNA degradation_Homo sapiens_hsa03018	1.37217879
28	RNA transport_Homo sapiens_hsa03013	1.28422095
29	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.26522275
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.24765407
31	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.17515653
32	Butanoate metabolism_Homo sapiens_hsa00650	1.15361651
33	Fatty acid elongation_Homo sapiens_hsa00062	1.11201332
34	ABC transporters_Homo sapiens_hsa02010	1.06374069
35	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.06322131
36	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.04415257
37	Steroid biosynthesis_Homo sapiens_hsa00100	1.03638462
38	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.03571739
39	Pyrimidine metabolism_Homo sapiens_hsa00240	1.00687957
40	Taste transduction_Homo sapiens_hsa04742	0.98718315
41	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.95829347
42	Thyroid cancer_Homo sapiens_hsa05216	0.93102762
43	Viral carcinogenesis_Homo sapiens_hsa05203	0.92493026
44	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.90166103
45	Purine metabolism_Homo sapiens_hsa00230	0.84531568
46	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.83540102
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.82219259
48	Oocyte meiosis_Homo sapiens_hsa04114	0.76899411
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.76473177
50	Proteasome_Homo sapiens_hsa03050	0.69551057
51	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.68806801
52	Linoleic acid metabolism_Homo sapiens_hsa00591	0.65909045
53	p53 signaling pathway_Homo sapiens_hsa04115	0.63743574
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.63273753
55	Morphine addiction_Homo sapiens_hsa05032	0.61709388
56	Spliceosome_Homo sapiens_hsa03040	0.61512266
57	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.60936123
58	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.55827230
59	Phototransduction_Homo sapiens_hsa04744	0.55783354
60	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.54497601
61	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.53502583
62	Colorectal cancer_Homo sapiens_hsa05210	0.49819717
63	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.49702214
64	ErbB signaling pathway_Homo sapiens_hsa04012	0.49531097
65	RNA polymerase_Homo sapiens_hsa03020	0.46425873
66	Pancreatic cancer_Homo sapiens_hsa05212	0.44676995
67	Protein export_Homo sapiens_hsa03060	0.44557042
68	GABAergic synapse_Homo sapiens_hsa04727	0.43829293
69	Prostate cancer_Homo sapiens_hsa05215	0.43719543
70	Fatty acid degradation_Homo sapiens_hsa00071	0.39221090
71	beta-Alanine metabolism_Homo sapiens_hsa00410	0.39054669
72	Carbon metabolism_Homo sapiens_hsa01200	0.38790489
73	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.38592359
74	Sphingolipid metabolism_Homo sapiens_hsa00600	0.38095869
75	Calcium signaling pathway_Homo sapiens_hsa04020	0.36638303
76	MicroRNAs in cancer_Homo sapiens_hsa05206	0.34344398
77	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.33840467
78	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.33706910
79	Nitrogen metabolism_Homo sapiens_hsa00910	0.33057017
80	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.32723645
81	Cholinergic synapse_Homo sapiens_hsa04725	0.31472514
82	Glucagon signaling pathway_Homo sapiens_hsa04922	0.30234379
83	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.29842718
84	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.28651835
85	FoxO signaling pathway_Homo sapiens_hsa04068	0.24310672
86	Serotonergic synapse_Homo sapiens_hsa04726	0.22659505
87	Endometrial cancer_Homo sapiens_hsa05213	0.22554694
88	Non-small cell lung cancer_Homo sapiens_hsa05223	0.21548261
89	Adherens junction_Homo sapiens_hsa04520	0.20884917
90	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.20011427
91	Metabolic pathways_Homo sapiens_hsa01100	0.19691203
92	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.18791768
93	Tight junction_Homo sapiens_hsa04530	0.17311285
94	Circadian rhythm_Homo sapiens_hsa04710	0.16507481
95	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.15324191
96	Peroxisome_Homo sapiens_hsa04146	0.15024287
97	Glioma_Homo sapiens_hsa05214	0.14172902
98	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.13982146
99	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.12163516
100	Circadian entrainment_Homo sapiens_hsa04713	0.11470493

PHBP12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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