ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	6.76864094
2	gamma-aminobutyric acid transport (GO:0015812)	6.74483048
3	response to pheromone (GO:0019236)	6.11956910
4	DNA integration (GO:0015074)	5.76713181
5	negative regulation of interleukin-1 beta production (GO:0032691)	5.13435832
6	regulation of cholesterol esterification (GO:0010872)	5.00884614
7	regulation of cytokine secretion involved in immune response (GO:0002739)	4.53623870
8	phospholipid homeostasis (GO:0055091)	4.45335589
9	phospholipid efflux (GO:0033700)	4.44086253
10	protein-lipid complex assembly (GO:0065005)	4.20626605
11	keratinocyte development (GO:0003334)	4.19130022
12	peroxisome fission (GO:0016559)	4.11611450
13	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.11268956
14	negative regulation of gene silencing (GO:0060969)	4.11008352
15	negative regulation of interleukin-1 production (GO:0032692)	4.10665055
16	high-density lipoprotein particle remodeling (GO:0034375)	3.86571508
17	plasma lipoprotein particle assembly (GO:0034377)	3.83426111
18	regulation of posttranscriptional gene silencing (GO:0060147)	3.81743851
19	regulation of gene silencing by miRNA (GO:0060964)	3.81743851
20	regulation of gene silencing by RNA (GO:0060966)	3.81743851
21	regulation of heterotypic cell-cell adhesion (GO:0034114)	3.81439232
22	regulation of female receptivity (GO:0045924)	3.74581896
23	bile acid biosynthetic process (GO:0006699)	3.63691938
24	fatty acid elongation (GO:0030497)	3.62463216
25	rRNA catabolic process (GO:0016075)	3.61962879
26	regulation of alkaline phosphatase activity (GO:0010692)	3.58857724
27	reverse cholesterol transport (GO:0043691)	3.58377978
28	piRNA metabolic process (GO:0034587)	3.54753389
29	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.50900436
30	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	3.49759141
31	maturation of 5.8S rRNA (GO:0000460)	3.46941268
32	female mating behavior (GO:0060180)	3.41813524
33	positive regulation of Rho protein signal transduction (GO:0035025)	3.38371657
34	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.30215447
35	dicarboxylic acid catabolic process (GO:0043649)	3.29873120
36	sex differentiation (GO:0007548)	3.25354737
37	regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)	3.25077764
38	S-adenosylmethionine metabolic process (GO:0046500)	3.24218121
39	transmission of nerve impulse (GO:0019226)	3.23456043
40	hippocampus development (GO:0021766)	3.20375547
41	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.19752054
42	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.19752054
43	male meiosis (GO:0007140)	3.17365640
44	regulation of Rac GTPase activity (GO:0032314)	3.12237040
45	male meiosis I (GO:0007141)	3.10890729
46	negative regulation of macrophage differentiation (GO:0045650)	3.07211364
47	regulation of interleukin-1 beta secretion (GO:0050706)	3.06841848
48	regulation of cofactor metabolic process (GO:0051193)	3.04267301
49	regulation of coenzyme metabolic process (GO:0051196)	3.04267301
50	synapsis (GO:0007129)	3.02167000
51	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.99768514
52	axon regeneration (GO:0031103)	2.96676157
53	phosphatidylcholine biosynthetic process (GO:0006656)	2.95816899
54	alpha-linolenic acid metabolic process (GO:0036109)	2.94959895
55	response to folic acid (GO:0051593)	2.94292592
56	water-soluble vitamin biosynthetic process (GO:0042364)	2.92145838
57	peptidyl-histidine modification (GO:0018202)	2.91695925
58	head development (GO:0060322)	2.91246162
59	neuronal action potential propagation (GO:0019227)	2.90992202
60	DNA double-strand break processing (GO:0000729)	2.90351887
61	cell migration involved in gastrulation (GO:0042074)	2.88438654
62	sequestering of actin monomers (GO:0042989)	2.86922377
63	glycosphingolipid biosynthetic process (GO:0006688)	2.85547357
64	regulation of cardioblast differentiation (GO:0051890)	2.84462271
65	respiratory chain complex IV assembly (GO:0008535)	2.83845150
66	negative chemotaxis (GO:0050919)	2.82264112
67	reflex (GO:0060004)	2.81006567
68	chromosome organization involved in meiosis (GO:0070192)	2.80681880
69	regulation of relaxation of muscle (GO:1901077)	2.78375981
70	photoreceptor cell maintenance (GO:0045494)	2.73843303
71	DNA dealkylation (GO:0035510)	2.71124734
72	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.69618915
73	meiotic chromosome segregation (GO:0045132)	2.69008151
74	outer ear morphogenesis (GO:0042473)	2.67859905
75	neurofilament cytoskeleton organization (GO:0060052)	2.67324746
76	regulation of interleukin-1 secretion (GO:0050704)	2.66328385
77	DNA methylation involved in gamete generation (GO:0043046)	2.63436992
78	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.61958066
79	carnitine transport (GO:0015879)	2.60438678
80	amino-acid betaine transport (GO:0015838)	2.60438678
81	negative regulation of lipase activity (GO:0060192)	2.59765857
82	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.58361209
83	positive regulation of CREB transcription factor activity (GO:0032793)	2.57515265
84	proteasome assembly (GO:0043248)	2.56457793
85	regulation of synapse assembly (GO:0051963)	2.53848267
86	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	2.53753155
87	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	2.52863495
88	positive regulation of protein homodimerization activity (GO:0090073)	2.52500268
89	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.52250210
90	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.52250210
91	otic vesicle formation (GO:0030916)	2.52060148
92	positive regulation of amino acid transport (GO:0051957)	2.51605172
93	cholesterol efflux (GO:0033344)	2.50422204
94	galactose catabolic process (GO:0019388)	2.48947620
95	meiosis I (GO:0007127)	2.48152750
96	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.47461888
97	cholesterol catabolic process (GO:0006707)	2.47344817
98	sterol catabolic process (GO:0016127)	2.47344817
99	homocysteine metabolic process (GO:0050667)	2.47128778
100	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.46713777

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.48465071
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.14774866
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.09269112
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.97758173
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.78052343
6	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.48646763
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.47140355
8	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.40277022
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.37224376
10	EWS_26573619_Chip-Seq_HEK293_Human	2.29402024
11	FUS_26573619_Chip-Seq_HEK293_Human	2.28113938
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.26223834
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.09935583
14	P300_19829295_ChIP-Seq_ESCs_Human	2.08403671
15	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.04166992
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.01582888
17	ZNF274_21170338_ChIP-Seq_K562_Hela	1.97845253
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97354529
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.89242517
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.87523867
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.87458132
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.83330772
23	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.82994179
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.81200315
25	RNF2_27304074_Chip-Seq_NSC_Mouse	1.72098230
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.69393612
27	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.67653793
28	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.65908218
29	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.64862425
30	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.62221071
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.61027168
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.61027168
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.60121471
34	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.57601485
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56400175
36	AR_21572438_ChIP-Seq_LNCaP_Human	1.54919059
37	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.53632473
38	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53286187
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.53286187
40	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.52323558
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.51246341
42	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.48583256
43	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.43115139
44	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42116220
45	ER_23166858_ChIP-Seq_MCF-7_Human	1.40139450
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37383602
47	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.37361562
48	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.35357076
49	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.34831797
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.34406592
51	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.34127512
52	STAT3_23295773_ChIP-Seq_U87_Human	1.32217612
53	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.31404039
54	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.31014351
55	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.30064650
56	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27997709
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.27724120
58	TCF4_23295773_ChIP-Seq_U87_Human	1.27703542
59	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.26114197
60	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.25734269
61	TP53_22573176_ChIP-Seq_HFKS_Human	1.24648464
62	AR_25329375_ChIP-Seq_VCAP_Human	1.24646592
63	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22328585
64	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.21616765
65	TBL1_22424771_ChIP-Seq_293T_Human	1.19968142
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.19873569
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18251882
68	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16601878
69	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.15834405
70	NFYB_21822215_ChIP-Seq_K562_Human	1.15754316
71	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.15546586
72	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.15112805
73	HTT_18923047_ChIP-ChIP_STHdh_Human	1.14292381
74	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.13396362
75	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.11540294
76	ELK1_19687146_ChIP-ChIP_HELA_Human	1.10764911
77	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10450651
78	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10450651
79	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10016800
80	BCAT_22108803_ChIP-Seq_LS180_Human	1.09669577
81	REST_21632747_ChIP-Seq_MESCs_Mouse	1.09617088
82	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.08980954
83	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.08847009
84	PHF8_20622853_ChIP-Seq_HELA_Human	1.08613602
85	MYC_18940864_ChIP-ChIP_HL60_Human	1.04879422
86	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.03901807
87	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.03803303
88	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.03443324
89	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.02989081
90	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.01723655
91	AR_20517297_ChIP-Seq_VCAP_Human	1.01377811
92	NFYA_21822215_ChIP-Seq_K562_Human	0.99871080
93	VDR_22108803_ChIP-Seq_LS180_Human	0.99808602
94	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.99529069
95	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.99529069
96	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.99529069
97	CBP_21632823_ChIP-Seq_H3396_Human	0.99105703
98	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98978446
99	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.98624837
100	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.96984892

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005451_abnormal_body_composition	5.46517878
2	MP0008004_abnormal_stomach_pH	3.76703533
3	MP0003646_muscle_fatigue	3.64440751
4	MP0003878_abnormal_ear_physiology	3.38512321
5	MP0005377_hearing/vestibular/ear_phenot	3.38512321
6	MP0001986_abnormal_taste_sensitivity	3.17866405
7	MP0004885_abnormal_endolymph	3.04698509
8	MP0008877_abnormal_DNA_methylation	2.98214905
9	MP0009840_abnormal_foam_cell	2.63194643
10	MP0000537_abnormal_urethra_morphology	2.56010901
11	MP0003191_abnormal_cellular_cholesterol	2.25192673
12	MP0000516_abnormal_urinary_system	2.16406466
13	MP0005367_renal/urinary_system_phenotyp	2.16406466
14	MP0003119_abnormal_digestive_system	2.12150550
15	MP0009046_muscle_twitch	2.03105763
16	MP0002102_abnormal_ear_morphology	1.96650913
17	MP0006276_abnormal_autonomic_nervous	1.94371224
18	MP0002736_abnormal_nociception_after	1.92754825
19	MP0005408_hypopigmentation	1.89415640
20	MP0008057_abnormal_DNA_replication	1.86019086
21	MP0004142_abnormal_muscle_tone	1.75256742
22	MP0003880_abnormal_central_pattern	1.73855596
23	MP0003693_abnormal_embryo_hatching	1.72985699
24	MP0005551_abnormal_eye_electrophysiolog	1.70551434
25	MP0003315_abnormal_perineum_morphology	1.64131489
26	MP0004147_increased_porphyrin_level	1.63461582
27	MP0002822_catalepsy	1.59840717
28	MP0002837_dystrophic_cardiac_calcinosis	1.55667155
29	MP0004270_analgesia	1.53554354
30	MP0002638_abnormal_pupillary_reflex	1.52635687
31	MP0000639_abnormal_adrenal_gland	1.49997334
32	MP0005187_abnormal_penis_morphology	1.49396477
33	MP0002909_abnormal_adrenal_gland	1.47909440
34	MP0005423_abnormal_somatic_nervous	1.44661940
35	MP0006072_abnormal_retinal_apoptosis	1.44565901
36	MP0001968_abnormal_touch/_nociception	1.43288016
37	MP0009745_abnormal_behavioral_response	1.42672354
38	MP0005253_abnormal_eye_physiology	1.42326984
39	MP0005248_abnormal_Harderian_gland	1.41541778
40	MP0008789_abnormal_olfactory_epithelium	1.41274610
41	MP0002160_abnormal_reproductive_system	1.40504538
42	MP0002277_abnormal_respiratory_mucosa	1.39936720
43	MP0000631_abnormal_neuroendocrine_gland	1.37673186
44	MP0002734_abnormal_mechanical_nocicepti	1.32036342
45	MP0005499_abnormal_olfactory_system	1.30643269
46	MP0005394_taste/olfaction_phenotype	1.30643269
47	MP0003879_abnormal_hair_cell	1.29794891
48	MP0001486_abnormal_startle_reflex	1.22921520
49	MP0001188_hyperpigmentation	1.20700659
50	MP0002233_abnormal_nose_morphology	1.20551396
51	MP0002184_abnormal_innervation	1.19204016
52	MP0002735_abnormal_chemical_nociception	1.17312648
53	MP0001984_abnormal_olfaction	1.16394253
54	MP0004043_abnormal_pH_regulation	1.14995276
55	MP0001666_abnormal_nutrient_absorption	1.13672366
56	MP0000778_abnormal_nervous_system	1.12797166
57	MP0001963_abnormal_hearing_physiology	1.11115633
58	MP0000383_abnormal_hair_follicle	1.09341340
59	MP0000049_abnormal_middle_ear	1.07843526
60	MP0010329_abnormal_lipoprotein_level	1.07632396
61	MP0002272_abnormal_nervous_system	1.03494067
62	MP0003195_calcinosis	1.02061739
63	MP0001919_abnormal_reproductive_system	1.01774695
64	MP0003698_abnormal_male_reproductive	1.01282043
65	MP0008995_early_reproductive_senescence	0.99243847
66	MP0003385_abnormal_body_wall	0.98874668
67	MP0002210_abnormal_sex_determination	0.98728965
68	MP0001440_abnormal_grooming_behavior	0.96577423
69	MP0002090_abnormal_vision	0.95935339
70	MP0000647_abnormal_sebaceous_gland	0.95428326
71	MP0002557_abnormal_social/conspecific_i	0.94548568
72	MP0003937_abnormal_limbs/digits/tail_de	0.89774709
73	MP0001929_abnormal_gametogenesis	0.89701106
74	MP0001664_abnormal_digestion	0.88668575
75	MP0003122_maternal_imprinting	0.88007493
76	MP0000026_abnormal_inner_ear	0.86322207
77	MP0005389_reproductive_system_phenotype	0.85240308
78	MP0008872_abnormal_physiological_respon	0.85171639
79	MP0002572_abnormal_emotion/affect_behav	0.84711058
80	MP0003787_abnormal_imprinting	0.83845597
81	MP0005075_abnormal_melanosome_morpholog	0.82633956
82	MP0004859_abnormal_synaptic_plasticity	0.82418991
83	MP0002067_abnormal_sensory_capabilities	0.82128499
84	MP0003635_abnormal_synaptic_transmissio	0.80956308
85	MP0002069_abnormal_eating/drinking_beha	0.80615631
86	MP0002064_seizures	0.79484840
87	MP0001905_abnormal_dopamine_level	0.78973719
88	MP0001145_abnormal_male_reproductive	0.78941605
89	MP0001529_abnormal_vocalization	0.78601245
90	MP0001324_abnormal_eye_pigmentation	0.78436015
91	MP0000653_abnormal_sex_gland	0.77814158
92	MP0005645_abnormal_hypothalamus_physiol	0.77428007
93	MP0001485_abnormal_pinna_reflex	0.76482856
94	MP0002752_abnormal_somatic_nervous	0.76426796
95	MP0004085_abnormal_heartbeat	0.73914162
96	MP0000427_abnormal_hair_cycle	0.70782436
97	MP0003137_abnormal_impulse_conducting	0.70398291
98	MP0001243_abnormal_dermal_layer	0.70313189
99	MP0004924_abnormal_behavior	0.69456717
100	MP0005386_behavior/neurological_phenoty	0.69456717

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic hepatic failure (HP:0100626)	5.26473525
2	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.89237571
3	Spontaneous abortion (HP:0005268)	3.95631919
4	Papilledema (HP:0001085)	3.82046635
5	Amyloidosis (HP:0011034)	3.80131204
6	Hypoalphalipoproteinemia (HP:0003233)	3.76963582
7	Intrahepatic cholestasis (HP:0001406)	3.65708155
8	Rectal fistula (HP:0100590)	3.57714345
9	Rectovaginal fistula (HP:0000143)	3.57714345
10	Chronic bronchitis (HP:0004469)	3.34305092
11	Pendular nystagmus (HP:0012043)	3.28899379
12	Intestinal fistula (HP:0100819)	3.26889479
13	Split foot (HP:0001839)	3.23751068
14	Oligodactyly (hands) (HP:0001180)	3.17363130
15	Acute necrotizing encephalopathy (HP:0006965)	3.10254473
16	Severe visual impairment (HP:0001141)	3.08909050
17	Acute encephalopathy (HP:0006846)	3.04940679
18	Renal cortical cysts (HP:0000803)	2.95836489
19	Tubulointerstitial nephritis (HP:0001970)	2.95091841
20	Rhinitis (HP:0012384)	2.93024587
21	Partial duplication of the phalanx of hand (HP:0009999)	2.89101576
22	Amyotrophic lateral sclerosis (HP:0007354)	2.88736769
23	Vaginal fistula (HP:0004320)	2.87483990
24	Increased hepatocellular lipid droplets (HP:0006565)	2.81490390
25	Pancreatic cysts (HP:0001737)	2.80372715
26	Horizontal nystagmus (HP:0000666)	2.75390618
27	Intestinal atresia (HP:0011100)	2.71861391
28	Turricephaly (HP:0000262)	2.67381557
29	Steatorrhea (HP:0002570)	2.64455924
30	Abnormal respiratory motile cilium physiology (HP:0012261)	2.64334367
31	Abnormality of the renal cortex (HP:0011035)	2.57065475
32	Hypolipoproteinemia (HP:0010981)	2.52845069
33	Fat malabsorption (HP:0002630)	2.51958215
34	Poor suck (HP:0002033)	2.51707540
35	Abnormal mitochondria in muscle tissue (HP:0008316)	2.49616388
36	Abolished electroretinogram (ERG) (HP:0000550)	2.49329941
37	Abnormality of the labia minora (HP:0012880)	2.47476426
38	Vacuolated lymphocytes (HP:0001922)	2.47033758
39	Progressive macrocephaly (HP:0004481)	2.44526834
40	Large for gestational age (HP:0001520)	2.42997282
41	Papillary thyroid carcinoma (HP:0002895)	2.42853030
42	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.42754772
43	Posterior subcapsular cataract (HP:0007787)	2.41554726
44	Mitochondrial inheritance (HP:0001427)	2.41520837
45	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.35861411
46	Fibular aplasia (HP:0002990)	2.32516290
47	Hypothermia (HP:0002045)	2.30895212
48	Pancreatic islet-cell hyperplasia (HP:0004510)	2.27470280
49	Increased CSF lactate (HP:0002490)	2.26936283
50	Respiratory difficulties (HP:0002880)	2.25442717
51	Medial flaring of the eyebrow (HP:0010747)	2.24239423
52	Renal Fanconi syndrome (HP:0001994)	2.20851367
53	Hyperglycinemia (HP:0002154)	2.18568310
54	3-Methylglutaconic aciduria (HP:0003535)	2.14518299
55	Type I transferrin isoform profile (HP:0003642)	2.13599011
56	Generalized aminoaciduria (HP:0002909)	2.13172538
57	Chorioretinal atrophy (HP:0000533)	2.12862586
58	Absent speech (HP:0001344)	2.11610050
59	Progressive sensorineural hearing impairment (HP:0000408)	2.11331288
60	Oligodactyly (HP:0012165)	2.10999071
61	Attenuation of retinal blood vessels (HP:0007843)	2.10253580
62	Hypoplastic pelvis (HP:0008839)	2.09221266
63	Lipid accumulation in hepatocytes (HP:0006561)	2.08239648
64	Retinal atrophy (HP:0001105)	2.08101122
65	Congenital primary aphakia (HP:0007707)	2.07246807
66	Epidermoid cyst (HP:0200040)	2.03907826
67	Ketoacidosis (HP:0001993)	2.03221284
68	Delayed CNS myelination (HP:0002188)	2.03030591
69	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.01451182
70	Gait imbalance (HP:0002141)	2.01031858
71	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.00274856
72	Severe Myopia (HP:0011003)	1.99691199
73	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.99119490
74	Abnormal protein N-linked glycosylation (HP:0012347)	1.99119490
75	Abnormal protein glycosylation (HP:0012346)	1.99119490
76	Abnormal glycosylation (HP:0012345)	1.99119490
77	Genital tract atresia (HP:0001827)	1.97502580
78	Epileptic encephalopathy (HP:0200134)	1.96485581
79	Bifid tongue (HP:0010297)	1.96134261
80	Hepatocellular necrosis (HP:0001404)	1.95161629
81	Hypoalbuminemia (HP:0003073)	1.92091975
82	Abnormal albumin level (HP:0012116)	1.92091975
83	Vaginal atresia (HP:0000148)	1.89181015
84	Abnormality of renal resorption (HP:0011038)	1.88901171
85	Fetal akinesia sequence (HP:0001989)	1.88606989
86	Neonatal onset (HP:0003623)	1.87914625
87	Partial duplication of thumb phalanx (HP:0009944)	1.86990694
88	Methylmalonic acidemia (HP:0002912)	1.85586222
89	Proximal tubulopathy (HP:0000114)	1.84002900
90	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.83794509
91	Poor coordination (HP:0002370)	1.83034850
92	Nephronophthisis (HP:0000090)	1.82597464
93	Colon cancer (HP:0003003)	1.82199844
94	Aplasia/hypoplasia of the uterus (HP:0008684)	1.82173525
95	Gingival bleeding (HP:0000225)	1.81620957
96	Abnormal rod and cone electroretinograms (HP:0008323)	1.80520097
97	Exertional dyspnea (HP:0002875)	1.79462714
98	Nephrotic syndrome (HP:0000100)	1.76810645
99	Hypoplastic left heart (HP:0004383)	1.76779804
100	Glycosuria (HP:0003076)	1.76229894

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K4	5.17708322
2	CDK19	4.83929042
3	PNCK	4.63425146
4	MAP2K7	4.25418830
5	WNK3	3.75255153
6	PASK	3.39226620
7	MAPK13	3.32022686
8	PDK2	2.64770472
9	EIF2AK1	2.63860478
10	EPHA4	2.08082971
11	MAP2K4	2.04643374
12	MAP3K9	2.04601473
13	EIF2AK3	2.00756935
14	PRKD3	1.94027516
15	GRK1	1.68435886
16	MET	1.66648096
17	STK38	1.66492572
18	TRIM28	1.58504485
19	DAPK2	1.53934789
20	CAMKK1	1.51036481
21	BCR	1.41411909
22	CASK	1.41350169
23	TAOK3	1.40181351
24	ERBB3	1.34625921
25	NME1	1.32332720
26	CCNB1	1.24647025
27	TYRO3	1.11983758
28	STK38L	1.11574439
29	MST4	1.07555770
30	FGR	1.04202687
31	TESK2	0.98267263
32	PTK2B	0.97648559
33	MARK1	0.96214717
34	LMTK2	0.95324966
35	SRPK1	0.95101489
36	ZAK	0.95049743
37	LIMK1	0.93858933
38	BMX	0.93801998
39	PLK4	0.92287362
40	MAP4K2	0.91946126
41	MAP3K6	0.90879784
42	CSF1R	0.89722659
43	VRK1	0.79895658
44	PRKCE	0.79423529
45	CAMKK2	0.73979046
46	PLK2	0.73028881
47	PRKCG	0.71275984
48	PDGFRB	0.68897274
49	RPS6KB1	0.68679030
50	CAMK1G	0.62553736
51	PKN1	0.61098079
52	FRK	0.60363718
53	OXSR1	0.59351012
54	BRD4	0.58510479
55	TESK1	0.56992328
56	AKT3	0.54461288
57	NTRK2	0.52917523
58	INSRR	0.51688115
59	RET	0.50333079
60	CSNK1G3	0.49308684
61	CSNK1G2	0.48010659
62	BMPR2	0.46606194
63	PINK1	0.46353744
64	DYRK3	0.44520595
65	CAMK2A	0.44117074
66	PAK3	0.43712566
67	OBSCN	0.43682727
68	ATR	0.43094729
69	CSNK1G1	0.42155986
70	PRKACB	0.41944229
71	EPHA3	0.41086723
72	KDR	0.40466645
73	FGFR1	0.38428497
74	MINK1	0.36110871
75	STK11	0.36037663
76	ATM	0.34663894
77	KSR1	0.33815573
78	EGFR	0.33571890
79	ROCK1	0.31451729
80	ERBB4	0.31373384
81	SCYL2	0.29573935
82	CDK5	0.28200543
83	ERBB2	0.27154327
84	CSNK1A1L	0.25073046
85	IGF1R	0.23796777
86	CSNK1D	0.23481603
87	RPS6KA2	0.22161598
88	PRKACA	0.22103842
89	PRKCA	0.21278350
90	KIT	0.19923455
91	DDR2	0.19892304
92	UHMK1	0.19884650
93	MAP3K10	0.18569535
94	CAMK4	0.18380340
95	PDK1	0.18264815
96	CAMK1	0.18035529
97	PAK1	0.17639236
98	RPS6KA4	0.17584664
99	PDPK1	0.17580029
100	WEE1	0.16271596

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	5.55776160
2	Protein export_Homo sapiens_hsa03060	3.44599768
3	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.14309516
4	Nicotine addiction_Homo sapiens_hsa05033	3.02565164
5	Fat digestion and absorption_Homo sapiens_hsa04975	2.79983583
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.63907923
7	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.51892498
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.44951482
9	GABAergic synapse_Homo sapiens_hsa04727	2.24083185
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.23457767
11	Circadian rhythm_Homo sapiens_hsa04710	2.18066118
12	RNA degradation_Homo sapiens_hsa03018	2.16394939
13	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.09888455
14	Parkinsons disease_Homo sapiens_hsa05012	1.90940178
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.86409557
16	Morphine addiction_Homo sapiens_hsa05032	1.85613382
17	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.55177591
18	Butanoate metabolism_Homo sapiens_hsa00650	1.51189310
19	Dopaminergic synapse_Homo sapiens_hsa04728	1.50723061
20	Circadian entrainment_Homo sapiens_hsa04713	1.50540862
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.47524487
22	Taste transduction_Homo sapiens_hsa04742	1.47318335
23	Phototransduction_Homo sapiens_hsa04744	1.46235085
24	Peroxisome_Homo sapiens_hsa04146	1.41334928
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.37506695
26	Fatty acid elongation_Homo sapiens_hsa00062	1.31221180
27	Alcoholism_Homo sapiens_hsa05034	1.30152458
28	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.16911251
29	Pyruvate metabolism_Homo sapiens_hsa00620	1.10774386
30	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.10330837
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.08303999
32	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.06554077
33	Collecting duct acid secretion_Homo sapiens_hsa04966	1.05377497
34	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.04953998
35	Olfactory transduction_Homo sapiens_hsa04740	1.03952941
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.98573386
37	Cholinergic synapse_Homo sapiens_hsa04725	0.96795346
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.96134517
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.95690358
40	Regulation of autophagy_Homo sapiens_hsa04140	0.95225479
41	Oocyte meiosis_Homo sapiens_hsa04114	0.95187490
42	Huntingtons disease_Homo sapiens_hsa05016	0.94963940
43	Amphetamine addiction_Homo sapiens_hsa05031	0.94290823
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.92058920
45	Nitrogen metabolism_Homo sapiens_hsa00910	0.91631634
46	Glutamatergic synapse_Homo sapiens_hsa04724	0.91255426
47	Serotonergic synapse_Homo sapiens_hsa04726	0.90952580
48	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.90812490
49	Alzheimers disease_Homo sapiens_hsa05010	0.90112857
50	Cardiac muscle contraction_Homo sapiens_hsa04260	0.89813729
51	Selenocompound metabolism_Homo sapiens_hsa00450	0.88811517
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.87986831
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.84949273
54	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84363618
55	Basal transcription factors_Homo sapiens_hsa03022	0.82794909
56	Insulin secretion_Homo sapiens_hsa04911	0.80232883
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.75093921
58	Type II diabetes mellitus_Homo sapiens_hsa04930	0.74817940
59	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.70194867
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.68282130
61	Steroid biosynthesis_Homo sapiens_hsa00100	0.65591545
62	Other glycan degradation_Homo sapiens_hsa00511	0.65129709
63	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.64248175
64	Sulfur metabolism_Homo sapiens_hsa00920	0.62740354
65	Purine metabolism_Homo sapiens_hsa00230	0.61688855
66	Metabolic pathways_Homo sapiens_hsa01100	0.61304624
67	African trypanosomiasis_Homo sapiens_hsa05143	0.59193507
68	Long-term potentiation_Homo sapiens_hsa04720	0.58219348
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.57872023
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57023653
71	Cocaine addiction_Homo sapiens_hsa05030	0.54889892
72	Primary immunodeficiency_Homo sapiens_hsa05340	0.54168273
73	Axon guidance_Homo sapiens_hsa04360	0.53782526
74	Retinol metabolism_Homo sapiens_hsa00830	0.48279508
75	cAMP signaling pathway_Homo sapiens_hsa04024	0.47511482
76	RNA transport_Homo sapiens_hsa03013	0.47468435
77	Fanconi anemia pathway_Homo sapiens_hsa03460	0.44870017
78	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.43698024
79	DNA replication_Homo sapiens_hsa03030	0.42736547
80	Glucagon signaling pathway_Homo sapiens_hsa04922	0.42706760
81	Mismatch repair_Homo sapiens_hsa03430	0.42633663
82	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.42312052
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.40831164
84	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.40482444
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.39593609
86	Linoleic acid metabolism_Homo sapiens_hsa00591	0.39241134
87	ErbB signaling pathway_Homo sapiens_hsa04012	0.38271858
88	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.35834752
89	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.35057789
90	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.31860825
91	Calcium signaling pathway_Homo sapiens_hsa04020	0.29989326
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.29208278
93	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.27492536
94	Ether lipid metabolism_Homo sapiens_hsa00565	0.27464651
95	Lysine degradation_Homo sapiens_hsa00310	0.27359943
96	Gastric acid secretion_Homo sapiens_hsa04971	0.27227678
97	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.25751860
98	Base excision repair_Homo sapiens_hsa03410	0.23438965
99	Propanoate metabolism_Homo sapiens_hsa00640	0.22236558
100	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.21900147

PHBP13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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