PHBP15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1auditory behavior (GO:0031223)6.19763838
2pyrimidine ribonucleoside catabolic process (GO:0046133)5.88766326
3tongue development (GO:0043586)5.54201428
4pyrimidine nucleotide catabolic process (GO:0006244)5.36253832
5ribonucleoside diphosphate metabolic process (GO:0009185)5.15853002
6resolution of meiotic recombination intermediates (GO:0000712)5.05527943
7primitive streak formation (GO:0090009)4.96951821
8positive regulation of gastrulation (GO:2000543)4.95058335
9NIK/NF-kappaB signaling (GO:0038061)4.72020670
10regulation of cell-cell adhesion mediated by cadherin (GO:2000047)4.64277157
11isoprenoid biosynthetic process (GO:0008299)4.35766259
12regulation of RIG-I signaling pathway (GO:0039535)4.34921670
13histone H4-K12 acetylation (GO:0043983)4.34907174
14positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.33615905
15activated T cell proliferation (GO:0050798)4.32511829
16mechanosensory behavior (GO:0007638)4.14617616
17endothelial tube morphogenesis (GO:0061154)4.05144039
18morphogenesis of an endothelium (GO:0003159)4.05144039
19necroptotic process (GO:0070266)3.93004142
20response to auditory stimulus (GO:0010996)3.91065624
21regulation of synapse structural plasticity (GO:0051823)3.86467165
22regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.82556683
23cytoplasmic mRNA processing body assembly (GO:0033962)3.76470047
24nerve growth factor signaling pathway (GO:0038180)3.70227344
25protein localization to Golgi apparatus (GO:0034067)3.66865541
26dopaminergic neuron differentiation (GO:0071542)3.66534256
27postsynaptic membrane organization (GO:0001941)3.60932382
28potassium ion export (GO:0071435)3.59782089
29neuron maturation (GO:0042551)3.56665623
30glycerol metabolic process (GO:0006071)3.56293663
31sequestering of actin monomers (GO:0042989)3.55639250
32dopamine transport (GO:0015872)3.52570546
33neuronal stem cell maintenance (GO:0097150)3.51189906
34protein polyglutamylation (GO:0018095)3.49965533
35purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.47620033
36somite rostral/caudal axis specification (GO:0032525)3.42885494
37interkinetic nuclear migration (GO:0022027)3.42170621
38fat-soluble vitamin biosynthetic process (GO:0042362)3.38758244
39positive regulation of mitochondrial fission (GO:0090141)3.35393542
40mating behavior (GO:0007617)3.30870595
41regulation of protein polyubiquitination (GO:1902914)3.29372716
42striatum development (GO:0021756)3.27578787
43alditol metabolic process (GO:0019400)3.23444093
44negative regulation of neurotransmitter transport (GO:0051589)3.21609705
45neuron cell-cell adhesion (GO:0007158)3.14506007
46phosphatidylserine acyl-chain remodeling (GO:0036150)3.13765488
47cellular response to nerve growth factor stimulus (GO:1990090)3.13396653
48response to nerve growth factor (GO:1990089)3.13396653
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.12261921
50central nervous system projection neuron axonogenesis (GO:0021952)3.10637399
51negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.09163107
52anterograde synaptic vesicle transport (GO:0048490)3.09140633
53fatty acid elongation (GO:0030497)3.08156310
54behavioral response to nicotine (GO:0035095)3.06133286
55monoubiquitinated protein deubiquitination (GO:0035520)3.05203775
56negative regulation of peptidyl-serine phosphorylation (GO:0033137)3.04804809
57parental behavior (GO:0060746)3.04242221
58negative regulation of gluconeogenesis (GO:0045721)3.02158664
59regulation of mitochondrial fission (GO:0090140)3.01746521
60purine deoxyribonucleotide metabolic process (GO:0009151)3.00940408
61presynaptic membrane assembly (GO:0097105)3.00771532
62prepulse inhibition (GO:0060134)3.00120512
63cell proliferation in forebrain (GO:0021846)2.99448277
64peroxisome fission (GO:0016559)2.97945281
65forebrain neuron differentiation (GO:0021879)2.95960115
66signal complex assembly (GO:0007172)2.94773011
67mannosylation (GO:0097502)2.90726200
68serotonin metabolic process (GO:0042428)2.90552150
69programmed necrotic cell death (GO:0097300)2.89043746
70myotube differentiation (GO:0014902)2.88513153
71pre-miRNA processing (GO:0031054)2.84963984
72negative regulation of neurotransmitter secretion (GO:0046929)2.83742627
73epithelial cell differentiation involved in kidney development (GO:0035850)2.83319739
74neuron recognition (GO:0008038)2.82908046
75positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.81736155
76regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.80752355
77dentate gyrus development (GO:0021542)2.80546324
78regulation of glycogen (starch) synthase activity (GO:2000465)2.79353051
79positive regulation of synapse assembly (GO:0051965)2.77785779
80regulation of female gonad development (GO:2000194)2.77358551
81phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.77091048
82ubiquinone metabolic process (GO:0006743)2.76666798
83cellular response to electrical stimulus (GO:0071257)2.76374990
84necrotic cell death (GO:0070265)2.74503026
85dopamine biosynthetic process (GO:0042416)2.71452781
86dendritic spine morphogenesis (GO:0060997)2.70615307
87regulation of hexokinase activity (GO:1903299)2.69545996
88regulation of glucokinase activity (GO:0033131)2.69545996
89central nervous system neuron axonogenesis (GO:0021955)2.66201159
90ubiquinone biosynthetic process (GO:0006744)2.65427722
91RNA destabilization (GO:0050779)2.65121253
92microtubule depolymerization (GO:0007019)2.62407761
93behavioral response to ethanol (GO:0048149)2.62307909
94vocalization behavior (GO:0071625)2.60837148
95post-embryonic morphogenesis (GO:0009886)2.60158268
96negative regulation of multicellular organism growth (GO:0040015)2.59602273
97rRNA catabolic process (GO:0016075)2.59336685
98purine deoxyribonucleotide catabolic process (GO:0009155)2.57173589
99phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.55999987
100nucleoside diphosphate catabolic process (GO:0009134)10.4718416

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse5.43301463
2IGF1R_20145208_ChIP-Seq_DFB_Human5.13443089
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.21781006
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.09772475
5TAF15_26573619_Chip-Seq_HEK293_Human2.96832962
6ZNF274_21170338_ChIP-Seq_K562_Hela2.77905973
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.68685574
8GBX2_23144817_ChIP-Seq_PC3_Human2.59553660
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.46800715
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.41862652
11FUS_26573619_Chip-Seq_HEK293_Human2.19647738
12MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse2.08736094
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02825306
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.01943504
15EZH2_22144423_ChIP-Seq_EOC_Human2.01452096
16SMAD4_21799915_ChIP-Seq_A2780_Human1.96551171
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95810619
18KLF5_20875108_ChIP-Seq_MESCs_Mouse1.88922374
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87825880
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84510405
21AR_21572438_ChIP-Seq_LNCaP_Human1.80088682
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.75156302
23GATA1_22025678_ChIP-Seq_K562_Human1.75016070
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73793185
25EWS_26573619_Chip-Seq_HEK293_Human1.71634071
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.68470168
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.65815129
28ELK1_19687146_ChIP-ChIP_HELA_Human1.62056609
29RNF2_27304074_Chip-Seq_NSC_Mouse1.60750978
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55485264
31TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55454170
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54380216
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.54207121
34AR_25329375_ChIP-Seq_VCAP_Human1.53912889
35ELK4_26923725_Chip-Seq_MESODERM_Mouse1.48660374
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47249993
37P300_19829295_ChIP-Seq_ESCs_Human1.46612842
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.45548951
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43920434
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.41482370
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.40849717
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39308222
43RUNX2_22187159_ChIP-Seq_PCA_Human1.38437966
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38204449
45HTT_18923047_ChIP-ChIP_STHdh_Human1.36988224
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.35267801
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34793246
48CBP_20019798_ChIP-Seq_JUKART_Human1.34793246
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34397539
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34172635
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34046182
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33357802
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31649029
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31525701
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31525701
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.30932645
57TP53_16413492_ChIP-PET_HCT116_Human1.29353013
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.28688750
59CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27709571
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25882836
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25639473
62E2F4_17652178_ChIP-ChIP_JURKAT_Human1.23875804
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22405437
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21886936
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20911083
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19393911
67SALL4_22934838_ChIP-ChIP_CD34+_Human1.18515681
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14761945
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14666452
70FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13771319
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.10584333
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09644322
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.08978125
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08679276
75STAT3_23295773_ChIP-Seq_U87_Human1.07705876
76TP53_20018659_ChIP-ChIP_R1E_Mouse1.06637337
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.05271816
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05028939
79KDM2B_26808549_Chip-Seq_REH_Human1.03495753
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02393893
81SOX2_16153702_ChIP-ChIP_HESCs_Human1.02130306
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00174424
83REST_21632747_ChIP-Seq_MESCs_Mouse0.96794523
84SOX9_26525672_Chip-Seq_HEART_Mouse0.94900477
85TAL1_26923725_Chip-Seq_HPCs_Mouse0.94751687
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94606700
87JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94081339
88E2F1_18555785_Chip-Seq_ESCs_Mouse0.92700137
89P53_22387025_ChIP-Seq_ESCs_Mouse0.92621507
90MYC_18940864_ChIP-ChIP_HL60_Human0.91774233
91ELF5_23300383_ChIP-Seq_T47D_Human0.91621287
92AHR_22903824_ChIP-Seq_MCF-7_Human0.91399803
93NCOR_22424771_ChIP-Seq_293T_Human0.91008152
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90793973
95REST_18959480_ChIP-ChIP_MESCs_Mouse0.90040565
96RXR_22108803_ChIP-Seq_LS180_Human0.87535559
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87290625
98TBL1_22424771_ChIP-Seq_293T_Human0.86720687
99TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86023810
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85212950

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004742_abnormal_vestibular_system4.57586235
2MP0001529_abnormal_vocalization3.31061957
3MP0000569_abnormal_digit_pigmentation2.83016884
4MP0003283_abnormal_digestive_organ2.69794537
5MP0005423_abnormal_somatic_nervous2.65311433
6MP0008961_abnormal_basal_metabolism2.63615185
7MP0003890_abnormal_embryonic-extraembry2.61990047
8MP0001188_hyperpigmentation2.45212548
9MP0003122_maternal_imprinting2.41074621
10MP0000778_abnormal_nervous_system2.28537794
11MP0003011_delayed_dark_adaptation2.21979077
12MP0002234_abnormal_pharynx_morphology2.16819689
13MP0006276_abnormal_autonomic_nervous2.15812328
14MP0003646_muscle_fatigue2.08825043
15MP0003880_abnormal_central_pattern2.00630893
16MP0001905_abnormal_dopamine_level2.00047142
17MP0002638_abnormal_pupillary_reflex1.98162020
18MP0004885_abnormal_endolymph1.92863972
19MP0002928_abnormal_bile_duct1.88258896
20MP0002822_catalepsy1.87479792
21MP0008877_abnormal_DNA_methylation1.84056332
22MP0001502_abnormal_circadian_rhythm1.78824896
23MP0004133_heterotaxia1.73318159
24MP0000631_abnormal_neuroendocrine_gland1.70299107
25MP0004270_analgesia1.68672859
26MP0003959_abnormal_lean_body1.65923574
27MP0001764_abnormal_homeostasis1.65194130
28MP0006072_abnormal_retinal_apoptosis1.58397063
29MP0002909_abnormal_adrenal_gland1.56103781
30MP0003119_abnormal_digestive_system1.52568205
31MP0001486_abnormal_startle_reflex1.52476689
32MP0002971_abnormal_brown_adipose1.49837282
33MP0005310_abnormal_salivary_gland1.48652904
34MP0002064_seizures1.45330921
35MP0003635_abnormal_synaptic_transmissio1.45228001
36MP0001485_abnormal_pinna_reflex1.42243095
37MP0002837_dystrophic_cardiac_calcinosis1.41799329
38MP0004142_abnormal_muscle_tone1.40228429
39MP0003121_genomic_imprinting1.35748851
40MP0005253_abnormal_eye_physiology1.35076037
41MP0002184_abnormal_innervation1.34993607
42MP0004883_abnormal_blood_vessel1.31273089
43MP0002751_abnormal_autonomic_nervous1.28474777
44MP0009379_abnormal_foot_pigmentation1.25864714
45MP0005645_abnormal_hypothalamus_physiol1.23708905
46MP0004043_abnormal_pH_regulation1.22758126
47MP0002067_abnormal_sensory_capabilities1.21405573
48MP0002572_abnormal_emotion/affect_behav1.17187650
49MP0003943_abnormal_hepatobiliary_system1.16869663
50MP0003787_abnormal_imprinting1.14292523
51MP0003183_abnormal_peptide_metabolism1.13302448
52MP0006292_abnormal_olfactory_placode1.11346808
53MP0005220_abnormal_exocrine_pancreas1.10547686
54MP0008058_abnormal_DNA_repair1.08916745
55MP0002063_abnormal_learning/memory/cond1.08077603
56MP0005551_abnormal_eye_electrophysiolog1.07670825
57MP0001984_abnormal_olfaction1.07440277
58MP0001986_abnormal_taste_sensitivity1.07398909
59MP0003315_abnormal_perineum_morphology1.06729013
60MP0009745_abnormal_behavioral_response1.06546188
61MP0001944_abnormal_pancreas_morphology1.05980297
62MP0000462_abnormal_digestive_system1.04164210
63MP0002127_abnormal_cardiovascular_syste1.03016753
64MP0009046_muscle_twitch1.01838073
65MP0005448_abnormal_energy_balance0.97839057
66MP0005195_abnormal_posterior_eye0.94850564
67MP0005075_abnormal_melanosome_morpholog0.92752946
68MP0003693_abnormal_embryo_hatching0.92437618
69MP0002970_abnormal_white_adipose0.91799373
70MP0004233_abnormal_muscle_weight0.91081067
71MP0002882_abnormal_neuron_morphology0.89959313
72MP0002277_abnormal_respiratory_mucosa0.88608896
73MP0004811_abnormal_neuron_physiology0.87821033
74MP0001191_abnormal_skin_condition0.87038763
75MP0002272_abnormal_nervous_system0.86733448
76MP0002152_abnormal_brain_morphology0.86096945
77MP0005248_abnormal_Harderian_gland0.85439470
78MP0005083_abnormal_biliary_tract0.85256580
79MP0009250_abnormal_appendicular_skeleto0.83337703
80MP0000751_myopathy0.81637729
81MP0002069_abnormal_eating/drinking_beha0.81547698
82MP0000955_abnormal_spinal_cord0.79769305
83MP0004085_abnormal_heartbeat0.78942029
84MP0005452_abnormal_adipose_tissue0.78194369
85MP0004134_abnormal_chest_morphology0.76314185
86MP0002752_abnormal_somatic_nervous0.76220855
87MP0003123_paternal_imprinting0.74054932
88MP0004808_abnormal_hematopoietic_stem0.72965715
89MP0003137_abnormal_impulse_conducting0.71543295
90MP0002066_abnormal_motor_capabilities/c0.69877875
91MP0002295_abnormal_pulmonary_circulatio0.69751698
92MP0001943_abnormal_respiration0.69485500
93MP0000750_abnormal_muscle_regeneration0.68428796
94MP0001340_abnormal_eyelid_morphology0.67623942
95MP0000026_abnormal_inner_ear0.66720324
96MP0005391_vision/eye_phenotype0.66694183
97MP0001440_abnormal_grooming_behavior0.66405009
98MP0005376_homeostasis/metabolism_phenot0.65733530
99MP0009115_abnormal_fat_cell0.65661348
100MP0002081_perinatal_lethality0.65397866

Predicted human phenotypes

RankGene SetZ-score
1Gonadotropin excess (HP:0000837)5.51603154
2Type II lissencephaly (HP:0007260)5.22556897
3Neonatal respiratory distress (HP:0002643)5.05567400
4Anterior segment dysgenesis (HP:0007700)4.56945796
5Retinal dysplasia (HP:0007973)4.28439143
6Progressive cerebellar ataxia (HP:0002073)3.84070141
7Oligodactyly (HP:0012165)3.79853185
8Genetic anticipation (HP:0003743)3.75907309
9Congenital primary aphakia (HP:0007707)3.66657972
10Gait imbalance (HP:0002141)3.64583135
11Partial agenesis of the corpus callosum (HP:0001338)3.62231023
12Nephrogenic diabetes insipidus (HP:0009806)3.47167021
13Abnormality of the aortic arch (HP:0012303)3.46480625
14Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.34957178
15Poor coordination (HP:0002370)3.28687364
16Medial flaring of the eyebrow (HP:0010747)3.22631349
17Fibular aplasia (HP:0002990)3.00916383
18Abnormal eating behavior (HP:0100738)2.85786428
19Spinal cord lesions (HP:0100561)2.81105139
20Syringomyelia (HP:0003396)2.81105139
21Aplasia/hypoplasia of the uterus (HP:0008684)2.78994070
22Specific learning disability (HP:0001328)2.78551098
23Cortical dysplasia (HP:0002539)2.77290176
24Cerebellar dysplasia (HP:0007033)2.73017328
25Intellectual disability, profound (HP:0002187)2.72653908
26Delayed epiphyseal ossification (HP:0002663)2.62252782
27Oligodactyly (hands) (HP:0001180)2.57740401
28Congenital stationary night blindness (HP:0007642)2.56881382
29Unilateral renal agenesis (HP:0000122)2.55789269
30Papillary thyroid carcinoma (HP:0002895)2.55548356
31Thyroid carcinoma (HP:0002890)2.50140316
32Abnormality of the phalanges of the 2nd finger (HP:0009541)2.47073118
33Broad foot (HP:0001769)2.46111124
34Carpal bone hypoplasia (HP:0001498)2.45697429
35Biliary tract neoplasm (HP:0100574)2.40506134
36Reduced antithrombin III activity (HP:0001976)2.37472529
37Genital tract atresia (HP:0001827)2.37126162
38Severe global developmental delay (HP:0011344)2.37052669
39Supernumerary bones of the axial skeleton (HP:0009144)2.35227323
40Acute lymphatic leukemia (HP:0006721)2.34191576
41Uterine leiomyosarcoma (HP:0002891)2.33001925
42Leiomyosarcoma (HP:0100243)2.33001925
43Optic nerve hypoplasia (HP:0000609)2.32310366
44Hyperventilation (HP:0002883)2.32118203
45Vaginal atresia (HP:0000148)2.30506887
46Transitional cell carcinoma of the bladder (HP:0006740)2.29333827
47Abnormality of the costochondral junction (HP:0000919)2.28772417
48Limb hypertonia (HP:0002509)2.24363083
49Hypoplastic iliac wings (HP:0002866)2.24224607
50Short foot (HP:0001773)2.23151262
51Metaphyseal dysplasia (HP:0100255)2.22607018
52Truncal obesity (HP:0001956)2.21364540
53Increased hepatocellular lipid droplets (HP:0006565)2.20618972
54Abnormality of dental color (HP:0011073)2.20066524
55Metaphyseal irregularity (HP:0003025)2.19653847
56Non-midline cleft lip (HP:0100335)2.16565112
57Aqueductal stenosis (HP:0002410)2.15217864
58Lissencephaly (HP:0001339)2.14684627
59Pachygyria (HP:0001302)2.13983141
60Hyperglycinemia (HP:0002154)2.12946647
61Brushfield spots (HP:0001088)2.12771055
62Thickened calvaria (HP:0002684)2.12553150
63Ulnar claw (HP:0001178)2.09467536
64Enlarged epiphyses (HP:0010580)2.07397583
65Hypoplastic pelvis (HP:0008839)2.03355287
66Arthropathy (HP:0003040)2.02749343
67Bladder neoplasm (HP:0009725)2.02057083
68Bladder carcinoma (HP:0002862)2.02057083
69Lipid accumulation in hepatocytes (HP:0006561)2.00731151
70Small hand (HP:0200055)2.00715125
71Hypoplasia of the pons (HP:0012110)2.00544993
72Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98963962
73Supernumerary ribs (HP:0005815)1.96533680
74Hypoplasia of the uterus (HP:0000013)1.95424395
75Limb dystonia (HP:0002451)1.93296052
76Abnormality of the nasal septum (HP:0000419)1.93173575
77Peripheral hypomyelination (HP:0007182)1.92220323
78Left ventricular hypertrophy (HP:0001712)1.91227043
79Polymicrogyria (HP:0002126)1.90315247
80Abnormality of the parietal bone (HP:0002696)1.89802719
81Aplasia/Hypoplasia of the tibia (HP:0005772)1.89657336
82Morphological abnormality of the middle ear (HP:0008609)1.86079930
83Short tibia (HP:0005736)1.84863240
84Hyperpituitarism (HP:0010514)1.84519477
85Curly hair (HP:0002212)1.82967083
86Annular pancreas (HP:0001734)1.82443967
87Myoglobinuria (HP:0002913)1.81052717
88Abnormality of the pubic bones (HP:0003172)1.80672561
89Abolished electroretinogram (ERG) (HP:0000550)1.80548570
90Thickened nuchal skin fold (HP:0000474)1.79119282
91Scanning speech (HP:0002168)1.78228789
92Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.77241814
93Thin bony cortex (HP:0002753)1.70813214
94Thoracic kyphosis (HP:0002942)1.69423662
95Upper limb muscle weakness (HP:0003484)1.69162059
96Hemiparesis (HP:0001269)1.67825007
97Aplasia/Hypoplasia of the lens (HP:0008063)1.66270368
98Flat occiput (HP:0005469)1.65971372
99Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.65065440
100Intellectual disability, progressive (HP:0006887)1.63714194

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.31319263
2RPS6KA44.00658447
3TRIM283.91833032
4CDC73.81402403
5ERN12.62578026
6CDK32.45392476
7ADRBK22.32778041
8MAP2K72.26873774
9SIK22.21532409
10UHMK12.16198567
11AKT32.09325275
12MATK1.90588142
13MAPK151.72463443
14FLT31.72362569
15TAOK11.55719413
16VRK11.54548649
17BUB11.53000517
18MKNK21.51934793
19MAP3K41.50364551
20TYRO31.44454891
21STK161.42805238
22BRSK21.42249888
23IRAK11.27107843
24ERBB21.23411632
25FRK1.19042528
26EPHB21.16885438
27PTK2B1.07166989
28CCNB11.02551891
29PASK1.02332843
30MARK10.97918614
31CHUK0.95646890
32NLK0.95174926
33CDC42BPA0.94806573
34MAPK130.91414155
35MKNK10.91016379
36CSNK1G30.90435763
37WNK30.87737928
38CAMK40.87055690
39PBK0.84456648
40SGK20.81336731
41NEK60.81220077
42DYRK30.81096766
43TRPM70.80873215
44CSNK1A1L0.80218257
45RPS6KA50.79490029
46CDK11A0.76125663
47CDK140.76048256
48PKN20.75767932
49TTK0.74958105
50MAP3K60.74744668
51CSF1R0.74516726
52MARK30.73824694
53CDK150.72915685
54HIPK20.71587901
55CDK180.71452192
56CSNK1G10.70342081
57NTRK10.70204211
58DDR20.68595533
59MAP2K40.67372859
60STK240.66573557
61NTRK20.65402168
62PRKD30.65085049
63PNCK0.64373650
64TAOK30.63715660
65YES10.61655942
66PDGFRA0.60324696
67PRKG20.56854547
68PAK30.55712907
69BCR0.54524630
70CSNK1G20.54128419
71PDGFRB0.52157289
72CDK190.51651089
73MAP4K10.51291457
74MARK20.49282320
75TGFBR10.48105677
76IRAK20.47948591
77ERBB40.47313482
78PLK10.43406556
79VRK20.40863958
80MAPK100.40637489
81PRKCH0.38565821
82SIK30.38507637
83TXK0.38415052
84CSNK1A10.38071732
85PLK30.37868730
86CHEK20.36275607
87STK110.34840283
88DYRK1B0.34741535
89NEK20.33359330
90RIPK40.32924048
91PRKCI0.31863388
92NUAK10.31732759
93PRKD20.30469771
94SRPK10.29571958
95TSSK60.28526930
96ATM0.28189441
97CAMKK20.28054274
98SGK4940.26529536
99SGK2230.26529536
100ZAK0.25532565

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.39532703
2Steroid biosynthesis_Homo sapiens_hsa001004.08082298
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.93703487
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.62318116
5Cocaine addiction_Homo sapiens_hsa050302.55075943
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.53160165
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.48060055
8Folate biosynthesis_Homo sapiens_hsa007902.46104634
9Mismatch repair_Homo sapiens_hsa034302.40975754
10Nicotine addiction_Homo sapiens_hsa050332.10022620
11Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.87115617
12Fatty acid elongation_Homo sapiens_hsa000621.85705139
13Butanoate metabolism_Homo sapiens_hsa006501.78380967
14Ether lipid metabolism_Homo sapiens_hsa005651.69005972
15Morphine addiction_Homo sapiens_hsa050321.65000161
16Inositol phosphate metabolism_Homo sapiens_hsa005621.61948731
17Thyroid cancer_Homo sapiens_hsa052161.60738683
18Taste transduction_Homo sapiens_hsa047421.57750646
19Circadian rhythm_Homo sapiens_hsa047101.54222476
20Insulin secretion_Homo sapiens_hsa049111.52578205
21Protein export_Homo sapiens_hsa030601.35927006
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34293357
23Pyrimidine metabolism_Homo sapiens_hsa002401.32962826
24Glycerolipid metabolism_Homo sapiens_hsa005611.31971022
25Purine metabolism_Homo sapiens_hsa002301.31636543
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31553652
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28912166
28Basal transcription factors_Homo sapiens_hsa030221.26392784
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23549221
30Alcoholism_Homo sapiens_hsa050341.22887006
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20271615
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.17268764
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.16263493
34Phototransduction_Homo sapiens_hsa047441.14375843
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07714598
36Serotonergic synapse_Homo sapiens_hsa047261.04103956
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03201380
38Huntingtons disease_Homo sapiens_hsa050161.02727311
39Notch signaling pathway_Homo sapiens_hsa043301.02206950
40Selenocompound metabolism_Homo sapiens_hsa004500.95257777
41Circadian entrainment_Homo sapiens_hsa047130.94384774
42Gap junction_Homo sapiens_hsa045400.93996681
43Sulfur metabolism_Homo sapiens_hsa009200.92303864
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92101507
45Fatty acid metabolism_Homo sapiens_hsa012120.90888756
46Sphingolipid metabolism_Homo sapiens_hsa006000.90784749
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90521316
48Wnt signaling pathway_Homo sapiens_hsa043100.86146237
49Adherens junction_Homo sapiens_hsa045200.85919763
50Oocyte meiosis_Homo sapiens_hsa041140.82500445
51Oxidative phosphorylation_Homo sapiens_hsa001900.78433303
52Basal cell carcinoma_Homo sapiens_hsa052170.77976273
53Parkinsons disease_Homo sapiens_hsa050120.77740958
54Spliceosome_Homo sapiens_hsa030400.77030405
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76590947
56Cell cycle_Homo sapiens_hsa041100.76062958
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75749324
58Propanoate metabolism_Homo sapiens_hsa006400.75158768
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72780468
60Systemic lupus erythematosus_Homo sapiens_hsa053220.70700933
61Amphetamine addiction_Homo sapiens_hsa050310.69317486
62RNA degradation_Homo sapiens_hsa030180.68110718
63Non-homologous end-joining_Homo sapiens_hsa034500.66947563
64Peroxisome_Homo sapiens_hsa041460.66425231
65Tryptophan metabolism_Homo sapiens_hsa003800.66161408
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65342857
67GABAergic synapse_Homo sapiens_hsa047270.65194238
68Homologous recombination_Homo sapiens_hsa034400.65058178
69Glutamatergic synapse_Homo sapiens_hsa047240.64016753
70Dopaminergic synapse_Homo sapiens_hsa047280.63419040
71Cardiac muscle contraction_Homo sapiens_hsa042600.63308992
72Lysosome_Homo sapiens_hsa041420.62804732
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62642524
74p53 signaling pathway_Homo sapiens_hsa041150.61609354
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57488153
76Bile secretion_Homo sapiens_hsa049760.56675612
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56147470
78mRNA surveillance pathway_Homo sapiens_hsa030150.55403464
79Thyroid hormone synthesis_Homo sapiens_hsa049180.54815908
80Axon guidance_Homo sapiens_hsa043600.52096283
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50418536
82Chemokine signaling pathway_Homo sapiens_hsa040620.49467115
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47378281
84Cholinergic synapse_Homo sapiens_hsa047250.46137799
85Calcium signaling pathway_Homo sapiens_hsa040200.43419316
86RNA polymerase_Homo sapiens_hsa030200.43245627
87Caffeine metabolism_Homo sapiens_hsa002320.42880665
88MicroRNAs in cancer_Homo sapiens_hsa052060.42385481
89Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42173416
90Hedgehog signaling pathway_Homo sapiens_hsa043400.40635071
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39755134
92Metabolic pathways_Homo sapiens_hsa011000.39056521
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36260636
94Fat digestion and absorption_Homo sapiens_hsa049750.34517425
95Oxytocin signaling pathway_Homo sapiens_hsa049210.32608825
96Herpes simplex infection_Homo sapiens_hsa051680.32455744
97Fatty acid biosynthesis_Homo sapiens_hsa000610.32338110
98TGF-beta signaling pathway_Homo sapiens_hsa043500.29285254
99Melanogenesis_Homo sapiens_hsa049160.29067863
100Gastric acid secretion_Homo sapiens_hsa049710.28851559

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