

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 6.66311729 |
| 2 | cytidine deamination (GO:0009972) | 6.11462623 |
| 3 | cytidine metabolic process (GO:0046087) | 6.11462623 |
| 4 | cytidine catabolic process (GO:0006216) | 6.11462623 |
| 5 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 5.25105418 |
| 6 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 5.21899441 |
| 7 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.63952986 |
| 8 | proteasome assembly (GO:0043248) | 4.53417484 |
| 9 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.44552206 |
| 10 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.43656199 |
| 11 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 4.35322136 |
| 12 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 4.35322136 |
| 13 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 4.35322136 |
| 14 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 4.32603644 |
| 15 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 4.32603644 |
| 16 | regulation of chronic inflammatory response (GO:0002676) | 4.25837130 |
| 17 | purine deoxyribonucleotide catabolic process (GO:0009155) | 4.25452750 |
| 18 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 4.13108597 |
| 19 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 4.12620346 |
| 20 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 4.12620346 |
| 21 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.12271214 |
| 22 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 4.09841232 |
| 23 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 4.04766439 |
| 24 | negative regulation of ligase activity (GO:0051352) | 4.02256294 |
| 25 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.02256294 |
| 26 | Peyers patch development (GO:0048541) | 3.93948455 |
| 27 | mucosal-associated lymphoid tissue development (GO:0048537) | 3.93948455 |
| 28 | cellular response to interleukin-15 (GO:0071350) | 3.85102852 |
| 29 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.83668669 |
| 30 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.82574139 |
| 31 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.81489815 |
| 32 | regulation of regulatory T cell differentiation (GO:0045589) | 3.81442620 |
| 33 | positive thymic T cell selection (GO:0045059) | 3.76386595 |
| 34 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.72434502 |
| 35 | purine deoxyribonucleotide metabolic process (GO:0009151) | 3.62742337 |
| 36 | positive T cell selection (GO:0043368) | 3.59929066 |
| 37 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.54988876 |
| 38 | positive regulation of cell cycle arrest (GO:0071158) | 3.54528854 |
| 39 | rRNA modification (GO:0000154) | 3.52141120 |
| 40 | platelet dense granule organization (GO:0060155) | 3.50394972 |
| 41 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.48320935 |
| 42 | pseudouridine synthesis (GO:0001522) | 3.47626536 |
| 43 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.47143072 |
| 44 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.46352516 |
| 45 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.41074825 |
| 46 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.40987696 |
| 47 | positive regulation of ligase activity (GO:0051351) | 3.40407076 |
| 48 | positive regulation of defense response to virus by host (GO:0002230) | 3.35264711 |
| 49 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.34121672 |
| 50 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.33380534 |
| 51 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.30641886 |
| 52 | ATP synthesis coupled proton transport (GO:0015986) | 3.30641886 |
| 53 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.30081177 |
| 54 | purine deoxyribonucleoside triphosphate metabolic process (GO:0009215) | 3.28864629 |
| 55 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 3.26814176 |
| 56 | regulation of cellular amine metabolic process (GO:0033238) | 3.25094467 |
| 57 | actin nucleation (GO:0045010) | 3.24001654 |
| 58 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.22684496 |
| 59 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.22684496 |
| 60 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.14827393 |
| 61 | positive regulation of calcium-mediated signaling (GO:0050850) | 3.11212689 |
| 62 | response to interferon-beta (GO:0035456) | 3.07419710 |
| 63 | rRNA methylation (GO:0031167) | 3.04830098 |
| 64 | iron-sulfur cluster assembly (GO:0016226) | 3.00937529 |
| 65 | metallo-sulfur cluster assembly (GO:0031163) | 3.00937529 |
| 66 | pyrimidine nucleoside catabolic process (GO:0046135) | 3.00391306 |
| 67 | regulation of cell cycle arrest (GO:0071156) | 2.99964382 |
| 68 | adaptation of signaling pathway (GO:0023058) | 2.98404138 |
| 69 | lymph node development (GO:0048535) | 2.97043291 |
| 70 | regulation of immunoglobulin secretion (GO:0051023) | 2.96669151 |
| 71 | negative regulation of T cell apoptotic process (GO:0070233) | 2.95278690 |
| 72 | regulation of cell killing (GO:0031341) | 2.92529850 |
| 73 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.90068013 |
| 74 | positive regulation of cell killing (GO:0031343) | 2.89854794 |
| 75 | negative T cell selection (GO:0043383) | 2.87417996 |
| 76 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.86979240 |
| 77 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.86979240 |
| 78 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.86912366 |
| 79 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 2.85659682 |
| 80 | deoxyribonucleotide catabolic process (GO:0009264) | 2.85180055 |
| 81 | interferon-gamma production (GO:0032609) | 2.83973064 |
| 82 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.83232948 |
| 83 | regulation of ligase activity (GO:0051340) | 2.83051447 |
| 84 | regulation of gamma-delta T cell differentiation (GO:0045586) | 2.82631524 |
| 85 | negative regulation of viral genome replication (GO:0045071) | 2.82276975 |
| 86 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 2.81662643 |
| 87 | response to interleukin-15 (GO:0070672) | 2.81363819 |
| 88 | negative regulation of thymocyte apoptotic process (GO:0070244) | 2.80687104 |
| 89 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 2.80591118 |
| 90 | protein neddylation (GO:0045116) | 2.79334740 |
| 91 | positive regulation of DNA recombination (GO:0045911) | 2.76018229 |
| 92 | positive regulation of tolerance induction (GO:0002645) | 2.74856466 |
| 93 | respiratory electron transport chain (GO:0022904) | 2.74751351 |
| 94 | negative regulation of G1/S transition of mitotic cell cycle (GO:2000134) | 2.74663797 |
| 95 | negative regulation of cell cycle G1/S phase transition (GO:1902807) | 2.74663797 |
| 96 | signal transduction in response to DNA damage (GO:0042770) | 2.74634575 |
| 97 | negative regulation of protein ubiquitination (GO:0031397) | 2.74007965 |
| 98 | kynurenine metabolic process (GO:0070189) | 2.73634056 |
| 99 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.70426581 |
| 100 | electron transport chain (GO:0022900) | 2.69047085 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.39628076 |
| 2 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 4.30641261 |
| 3 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 4.11955865 |
| 4 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.95274845 |
| 5 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.85658895 |
| 6 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.76202231 |
| 7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.26899700 |
| 8 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.21884409 |
| 9 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.17759916 |
| 10 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.52884189 |
| 11 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.51711049 |
| 12 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.48374885 |
| 13 | VDR_22108803_ChIP-Seq_LS180_Human | 2.45112723 |
| 14 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.42960191 |
| 15 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.28903976 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.04406539 |
| 17 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.04204555 |
| 18 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.01692822 |
| 19 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.00811147 |
| 20 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.00620429 |
| 21 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.94310269 |
| 22 | MYB_26560356_Chip-Seq_TH2_Human | 1.84641785 |
| 23 | GATA3_26560356_Chip-Seq_TH2_Human | 1.80376134 |
| 24 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.76562015 |
| 25 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.73875984 |
| 26 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.68382836 |
| 27 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.68066145 |
| 28 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.64882292 |
| 29 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.64035346 |
| 30 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.57625734 |
| 31 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.57344441 |
| 32 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.54363216 |
| 33 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.53646618 |
| 34 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.51834478 |
| 35 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.50851663 |
| 36 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.50220791 |
| 37 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.48624288 |
| 38 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.46768031 |
| 39 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.46336001 |
| 40 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.44512765 |
| 41 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.37935948 |
| 42 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.36010028 |
| 43 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.35056151 |
| 44 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.34179152 |
| 45 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.32216251 |
| 46 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.30351015 |
| 47 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.30287308 |
| 48 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.29327742 |
| 49 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.27108289 |
| 50 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.27104660 |
| 51 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.25588240 |
| 52 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.24694793 |
| 53 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.23501577 |
| 54 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.23501577 |
| 55 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.23183996 |
| 56 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.22062154 |
| 57 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.21676395 |
| 58 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.21461222 |
| 59 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.21359538 |
| 60 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.20618873 |
| 61 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.20034917 |
| 62 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 1.16581850 |
| 63 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.15387538 |
| 64 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.15133219 |
| 65 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.13336189 |
| 66 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.11286296 |
| 67 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.11019304 |
| 68 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.10521442 |
| 69 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.10272414 |
| 70 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.08755205 |
| 71 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.08276740 |
| 72 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.07661937 |
| 73 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 1.06988176 |
| 74 | AR_20517297_ChIP-Seq_VCAP_Human | 1.05958824 |
| 75 | MYB_26560356_Chip-Seq_TH1_Human | 1.05946222 |
| 76 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.04622401 |
| 77 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.03885923 |
| 78 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.03885923 |
| 79 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 1.03498789 |
| 80 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.02601486 |
| 81 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.02564564 |
| 82 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.01308553 |
| 83 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.00250520 |
| 84 | ERA_21632823_ChIP-Seq_H3396_Human | 0.99613249 |
| 85 | EWS_26573619_Chip-Seq_HEK293_Human | 0.99381657 |
| 86 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.99331087 |
| 87 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.98475476 |
| 88 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.98271516 |
| 89 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.98147841 |
| 90 | NCOR_22424771_ChIP-Seq_293T_Human | 0.97050214 |
| 91 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.96902073 |
| 92 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.96224602 |
| 93 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.95946775 |
| 94 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.95939407 |
| 95 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.94454939 |
| 96 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.92851840 |
| 97 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.92819987 |
| 98 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.90807627 |
| 99 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.90231048 |
| 100 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.89003527 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005671_abnormal_response_to | 4.40367578 |
| 2 | MP0001835_abnormal_antigen_presentation | 3.58978496 |
| 3 | MP0000685_abnormal_immune_system | 3.23542861 |
| 4 | MP0009785_altered_susceptibility_to | 2.73644717 |
| 5 | MP0005084_abnormal_gallbladder_morpholo | 2.57265374 |
| 6 | MP0008872_abnormal_physiological_respon | 2.50109259 |
| 7 | MP0008875_abnormal_xenobiotic_pharmacok | 2.49293832 |
| 8 | MP0002148_abnormal_hypersensitivity_rea | 2.41022074 |
| 9 | MP0002138_abnormal_hepatobiliary_system | 2.35670643 |
| 10 | MP0005000_abnormal_immune_tolerance | 2.23961556 |
| 11 | MP0009333_abnormal_splenocyte_physiolog | 2.20386147 |
| 12 | MP0002102_abnormal_ear_morphology | 2.18337154 |
| 13 | MP0002006_tumorigenesis | 2.13663354 |
| 14 | MP0001790_abnormal_immune_system | 2.00542398 |
| 15 | MP0005387_immune_system_phenotype | 2.00542398 |
| 16 | MP0003763_abnormal_thymus_physiology | 1.99865098 |
| 17 | MP0001501_abnormal_sleep_pattern | 1.94400729 |
| 18 | MP0002723_abnormal_immune_serum | 1.90020706 |
| 19 | MP0001800_abnormal_humoral_immune | 1.89059572 |
| 20 | MP0000372_irregular_coat_pigmentation | 1.88338469 |
| 21 | MP0009764_decreased_sensitivity_to | 1.87179556 |
| 22 | MP0002166_altered_tumor_susceptibility | 1.86983172 |
| 23 | MP0005025_abnormal_response_to | 1.84610082 |
| 24 | MP0002420_abnormal_adaptive_immunity | 1.83089349 |
| 25 | MP0003252_abnormal_bile_duct | 1.81132636 |
| 26 | MP0001819_abnormal_immune_cell | 1.79469775 |
| 27 | MP0003724_increased_susceptibility_to | 1.78087479 |
| 28 | MP0001968_abnormal_touch/_nociception | 1.71822294 |
| 29 | MP0003646_muscle_fatigue | 1.71093758 |
| 30 | MP0002837_dystrophic_cardiac_calcinosis | 1.69120185 |
| 31 | MP0001881_abnormal_mammary_gland | 1.64420672 |
| 32 | MP0003786_premature_aging | 1.64078776 |
| 33 | MP0005645_abnormal_hypothalamus_physiol | 1.63854158 |
| 34 | MP0002452_abnormal_antigen_presenting | 1.55636158 |
| 35 | MP0008058_abnormal_DNA_repair | 1.53849137 |
| 36 | MP0002736_abnormal_nociception_after | 1.53710264 |
| 37 | MP0003866_abnormal_defecation | 1.52976574 |
| 38 | MP0001873_stomach_inflammation | 1.45858237 |
| 39 | MP0003195_calcinosis | 1.44812977 |
| 40 | MP0000716_abnormal_immune_system | 1.43300914 |
| 41 | MP0002398_abnormal_bone_marrow | 1.37251523 |
| 42 | MP0006082_CNS_inflammation | 1.37114915 |
| 43 | MP0006072_abnormal_retinal_apoptosis | 1.34675630 |
| 44 | MP0005165_increased_susceptibility_to | 1.33485167 |
| 45 | MP0000689_abnormal_spleen_morphology | 1.33053281 |
| 46 | MP0010234_abnormal_vibrissa_follicle | 1.32721348 |
| 47 | MP0003806_abnormal_nucleotide_metabolis | 1.32103332 |
| 48 | MP0002405_respiratory_system_inflammati | 1.31961865 |
| 49 | MP0001188_hyperpigmentation | 1.29402638 |
| 50 | MP0010155_abnormal_intestine_physiology | 1.28378050 |
| 51 | MP0008877_abnormal_DNA_methylation | 1.26465357 |
| 52 | MP0003436_decreased_susceptibility_to | 1.25467453 |
| 53 | MP0003693_abnormal_embryo_hatching | 1.23799138 |
| 54 | MP0002933_joint_inflammation | 1.21858747 |
| 55 | MP0000703_abnormal_thymus_morphology | 1.21412281 |
| 56 | MP0005410_abnormal_fertilization | 1.21158430 |
| 57 | MP0003075_altered_response_to | 1.19438922 |
| 58 | MP0001845_abnormal_inflammatory_respons | 1.18851542 |
| 59 | MP0005646_abnormal_pituitary_gland | 1.17027978 |
| 60 | MP0002163_abnormal_gland_morphology | 1.17005033 |
| 61 | MP0002429_abnormal_blood_cell | 1.16008332 |
| 62 | MP0004381_abnormal_hair_follicle | 1.13337754 |
| 63 | MP0002419_abnormal_innate_immunity | 1.13078327 |
| 64 | MP0006036_abnormal_mitochondrial_physio | 1.12581933 |
| 65 | MP0002722_abnormal_immune_system | 1.10503625 |
| 66 | MP0001905_abnormal_dopamine_level | 1.09860546 |
| 67 | MP0006276_abnormal_autonomic_nervous | 1.09859046 |
| 68 | MP0000604_amyloidosis | 1.04518774 |
| 69 | MP0003718_maternal_effect | 1.02173972 |
| 70 | MP0000627_abnormal_mammary_gland | 1.01900400 |
| 71 | MP0002019_abnormal_tumor_incidence | 1.01371766 |
| 72 | MP0008469_abnormal_protein_level | 1.00732760 |
| 73 | MP0006035_abnormal_mitochondrial_morpho | 0.99654489 |
| 74 | MP0003011_delayed_dark_adaptation | 0.99209796 |
| 75 | MP0004947_skin_inflammation | 0.99169242 |
| 76 | MP0002733_abnormal_thermal_nociception | 0.98701140 |
| 77 | MP0002277_abnormal_respiratory_mucosa | 0.97857887 |
| 78 | MP0005551_abnormal_eye_electrophysiolog | 0.96168026 |
| 79 | MP0010386_abnormal_urinary_bladder | 0.95972132 |
| 80 | MP0001919_abnormal_reproductive_system | 0.93384991 |
| 81 | MP0005389_reproductive_system_phenotype | 0.93335205 |
| 82 | MP0001853_heart_inflammation | 0.93211321 |
| 83 | MP0004147_increased_porphyrin_level | 0.92702363 |
| 84 | MP0008873_increased_physiological_sensi | 0.89647803 |
| 85 | MP0003638_abnormal_response/metabolism_ | 0.89449524 |
| 86 | MP0009697_abnormal_copulation | 0.89125855 |
| 87 | MP0009763_increased_sensitivity_to | 0.87302963 |
| 88 | MP0000465_gastrointestinal_hemorrhage | 0.85764280 |
| 89 | MP0001986_abnormal_taste_sensitivity | 0.85039605 |
| 90 | MP0001533_abnormal_skeleton_physiology | 0.85025445 |
| 91 | MP0004145_abnormal_muscle_electrophysio | 0.84946810 |
| 92 | MP0005377_hearing/vestibular/ear_phenot | 0.84734407 |
| 93 | MP0003878_abnormal_ear_physiology | 0.84734407 |
| 94 | MP0001984_abnormal_olfaction | 0.84662493 |
| 95 | MP0002693_abnormal_pancreas_physiology | 0.84375192 |
| 96 | MP0001348_abnormal_lacrimal_gland | 0.84003583 |
| 97 | MP0005636_abnormal_mineral_homeostasis | 0.83688236 |
| 98 | MP0003936_abnormal_reproductive_system | 0.82587958 |
| 99 | MP0009643_abnormal_urine_homeostasis | 0.81301966 |
| 100 | MP0003448_altered_tumor_morphology | 0.80784189 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Stomatitis (HP:0010280) | 5.25198621 |
| 2 | IgG deficiency (HP:0004315) | 4.60121894 |
| 3 | Elevated erythrocyte sedimentation rate (HP:0003565) | 4.36085131 |
| 4 | Increased intramyocellular lipid droplets (HP:0012240) | 4.10327197 |
| 5 | Severe combined immunodeficiency (HP:0004430) | 4.05362795 |
| 6 | Hepatocellular necrosis (HP:0001404) | 3.89590853 |
| 7 | T lymphocytopenia (HP:0005403) | 3.74229014 |
| 8 | Aplastic anemia (HP:0001915) | 3.72385102 |
| 9 | Mitochondrial inheritance (HP:0001427) | 3.68499479 |
| 10 | Increased hepatocellular lipid droplets (HP:0006565) | 3.66150086 |
| 11 | Abnormality of T cell number (HP:0011839) | 3.59434284 |
| 12 | Increased muscle lipid content (HP:0009058) | 3.51993354 |
| 13 | Increased CSF lactate (HP:0002490) | 3.50724322 |
| 14 | Lipid accumulation in hepatocytes (HP:0006561) | 3.38709272 |
| 15 | Increased IgM level (HP:0003496) | 3.37339087 |
| 16 | Hepatic necrosis (HP:0002605) | 3.34173747 |
| 17 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.31099352 |
| 18 | Acute necrotizing encephalopathy (HP:0006965) | 3.29155168 |
| 19 | Combined immunodeficiency (HP:0005387) | 3.17077805 |
| 20 | Renal Fanconi syndrome (HP:0001994) | 3.15504134 |
| 21 | Acute encephalopathy (HP:0006846) | 2.99121582 |
| 22 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.94069629 |
| 23 | Abnormality of T cells (HP:0002843) | 2.94019126 |
| 24 | Congenital stationary night blindness (HP:0007642) | 2.93134381 |
| 25 | Abnormality of eosinophils (HP:0001879) | 2.86112011 |
| 26 | Spastic paraparesis (HP:0002313) | 2.84574437 |
| 27 | Type 2 muscle fiber atrophy (HP:0003554) | 2.83965546 |
| 28 | Hypoproteinemia (HP:0003075) | 2.75252902 |
| 29 | Retrobulbar optic neuritis (HP:0100654) | 2.68231724 |
| 30 | Optic neuritis (HP:0100653) | 2.68231724 |
| 31 | Thyroiditis (HP:0100646) | 2.67383186 |
| 32 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.66491300 |
| 33 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.61175550 |
| 34 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.61175550 |
| 35 | Recurrent bronchitis (HP:0002837) | 2.59589144 |
| 36 | Cerebral edema (HP:0002181) | 2.58667482 |
| 37 | Eosinophilia (HP:0001880) | 2.58527559 |
| 38 | Myositis (HP:0100614) | 2.58381739 |
| 39 | Progressive macrocephaly (HP:0004481) | 2.58288269 |
| 40 | Pancreatic cysts (HP:0001737) | 2.55592136 |
| 41 | Autoimmune hemolytic anemia (HP:0001890) | 2.52053136 |
| 42 | Methylmalonic acidemia (HP:0002912) | 2.51501889 |
| 43 | Increased serum lactate (HP:0002151) | 2.49775880 |
| 44 | Exertional dyspnea (HP:0002875) | 2.49439228 |
| 45 | Oral leukoplakia (HP:0002745) | 2.45849612 |
| 46 | Muscle fiber atrophy (HP:0100295) | 2.43654599 |
| 47 | Prostate neoplasm (HP:0100787) | 2.42037693 |
| 48 | Microretrognathia (HP:0000308) | 2.33608350 |
| 49 | Cerebral hypomyelination (HP:0006808) | 2.31133568 |
| 50 | Lactic acidosis (HP:0003128) | 2.28072360 |
| 51 | Conical tooth (HP:0000698) | 2.27680404 |
| 52 | 3-Methylglutaconic aciduria (HP:0003535) | 2.26964236 |
| 53 | Abnormality of the prostate (HP:0008775) | 2.25510823 |
| 54 | Abnormality of alanine metabolism (HP:0010916) | 2.20677105 |
| 55 | Hyperalaninemia (HP:0003348) | 2.20677105 |
| 56 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.20677105 |
| 57 | Orchitis (HP:0100796) | 2.18808306 |
| 58 | Decreased central vision (HP:0007663) | 2.17144441 |
| 59 | Short tibia (HP:0005736) | 2.15976222 |
| 60 | Hypoplasia of the pons (HP:0012110) | 2.15658863 |
| 61 | Keratoconjunctivitis sicca (HP:0001097) | 2.15349768 |
| 62 | Sensory axonal neuropathy (HP:0003390) | 2.15268655 |
| 63 | Respiratory difficulties (HP:0002880) | 2.14367275 |
| 64 | Severe visual impairment (HP:0001141) | 2.13099545 |
| 65 | Abnormality of the pons (HP:0007361) | 2.13093306 |
| 66 | Chronic diarrhea (HP:0002028) | 2.11779646 |
| 67 | Keratoconjunctivitis (HP:0001096) | 2.08109823 |
| 68 | Lethargy (HP:0001254) | 2.08060511 |
| 69 | Abnormality of B cell number (HP:0010975) | 2.07279894 |
| 70 | Abnormality of T cell physiology (HP:0011840) | 2.06288902 |
| 71 | Pancytopenia (HP:0001876) | 2.06113696 |
| 72 | Methylmalonic aciduria (HP:0012120) | 2.05934499 |
| 73 | Pustule (HP:0200039) | 2.05622715 |
| 74 | Congenital, generalized hypertrichosis (HP:0004540) | 2.04979903 |
| 75 | Exercise intolerance (HP:0003546) | 2.04469061 |
| 76 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.03204988 |
| 77 | Abolished electroretinogram (ERG) (HP:0000550) | 2.02858991 |
| 78 | Recurrent cutaneous fungal infections (HP:0011370) | 2.01506522 |
| 79 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.01506522 |
| 80 | Encephalitis (HP:0002383) | 1.98920061 |
| 81 | Facial diplegia (HP:0001349) | 1.96836987 |
| 82 | Granulocytopenia (HP:0001913) | 1.94676629 |
| 83 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.94672522 |
| 84 | Abnormality of the renal cortex (HP:0011035) | 1.94586397 |
| 85 | Polydipsia (HP:0001959) | 1.94450747 |
| 86 | Abnormal drinking behavior (HP:0030082) | 1.94450747 |
| 87 | Attenuation of retinal blood vessels (HP:0007843) | 1.94324934 |
| 88 | Leukocytosis (HP:0001974) | 1.93940709 |
| 89 | Type I transferrin isoform profile (HP:0003642) | 1.92995072 |
| 90 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.92036957 |
| 91 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.91689211 |
| 92 | Dicarboxylic aciduria (HP:0003215) | 1.91689211 |
| 93 | Gaze-evoked nystagmus (HP:0000640) | 1.90610257 |
| 94 | Abnormal albumin level (HP:0012116) | 1.86459419 |
| 95 | Hypoalbuminemia (HP:0003073) | 1.86459419 |
| 96 | Chronic sinusitis (HP:0011109) | 1.85676316 |
| 97 | B lymphocytopenia (HP:0010976) | 1.83328339 |
| 98 | Delayed CNS myelination (HP:0002188) | 1.82323058 |
| 99 | Polyuria (HP:0000103) | 1.81453757 |
| 100 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.80912046 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDR | 4.70122098 |
| 2 | TXK | 3.56018191 |
| 3 | TESK2 | 3.49646823 |
| 4 | BCKDK | 3.46524470 |
| 5 | ZAK | 2.67476573 |
| 6 | EIF2AK3 | 2.59396638 |
| 7 | TLK1 | 2.51593546 |
| 8 | MAPKAPK3 | 2.43130963 |
| 9 | VRK2 | 2.40598438 |
| 10 | MAP3K14 | 2.32855138 |
| 11 | BUB1 | 2.29868728 |
| 12 | MST4 | 2.25547650 |
| 13 | SRPK1 | 2.23761833 |
| 14 | TAOK3 | 2.19176403 |
| 15 | NUAK1 | 2.17143061 |
| 16 | MAP3K12 | 2.12642888 |
| 17 | ADRBK2 | 2.07430168 |
| 18 | TIE1 | 1.95413595 |
| 19 | MAP4K2 | 1.90326590 |
| 20 | INSRR | 1.86593410 |
| 21 | GRK1 | 1.80848047 |
| 22 | DAPK1 | 1.75518962 |
| 23 | LIMK1 | 1.67858297 |
| 24 | TSSK6 | 1.65570346 |
| 25 | EIF2AK1 | 1.64074456 |
| 26 | STK39 | 1.57005546 |
| 27 | TESK1 | 1.41785951 |
| 28 | PDK2 | 1.29154120 |
| 29 | MAP4K1 | 1.26182890 |
| 30 | WNK4 | 1.22016451 |
| 31 | NME1 | 1.20806528 |
| 32 | OXSR1 | 1.18672515 |
| 33 | TRIM28 | 1.18564883 |
| 34 | PRKCQ | 1.16048715 |
| 35 | NEK1 | 1.13079587 |
| 36 | ITK | 1.11065626 |
| 37 | KIT | 1.10694500 |
| 38 | IKBKE | 1.10304428 |
| 39 | GRK6 | 1.04693416 |
| 40 | TEC | 1.02375908 |
| 41 | NME2 | 1.01243300 |
| 42 | FES | 0.98483908 |
| 43 | IKBKB | 0.98272113 |
| 44 | EIF2AK2 | 0.96857931 |
| 45 | MYLK | 0.96384489 |
| 46 | VRK1 | 0.93200373 |
| 47 | SYK | 0.90115919 |
| 48 | MAP3K4 | 0.88865485 |
| 49 | LCK | 0.85487145 |
| 50 | MKNK1 | 0.85052376 |
| 51 | PIM2 | 0.80091217 |
| 52 | PIK3CA | 0.79568926 |
| 53 | SCYL2 | 0.76097125 |
| 54 | JAK3 | 0.74106898 |
| 55 | BTK | 0.73873778 |
| 56 | MAPKAPK5 | 0.72232627 |
| 57 | PINK1 | 0.71756971 |
| 58 | RPS6KA5 | 0.70900857 |
| 59 | PHKG2 | 0.69383192 |
| 60 | PHKG1 | 0.69383192 |
| 61 | PLK2 | 0.67388728 |
| 62 | MAP3K6 | 0.62524578 |
| 63 | FRK | 0.60401144 |
| 64 | CSNK1G3 | 0.57759271 |
| 65 | OBSCN | 0.57150230 |
| 66 | PLK3 | 0.55749351 |
| 67 | MATK | 0.55430544 |
| 68 | STK16 | 0.55012374 |
| 69 | TNK2 | 0.53067182 |
| 70 | MAP2K2 | 0.50447470 |
| 71 | ARAF | 0.46875155 |
| 72 | CSNK1A1L | 0.46582991 |
| 73 | IGF1R | 0.46133635 |
| 74 | ERBB3 | 0.45878811 |
| 75 | LYN | 0.45848094 |
| 76 | PRKCI | 0.44889000 |
| 77 | MAP2K6 | 0.44276917 |
| 78 | PLK1 | 0.43409650 |
| 79 | CAMKK2 | 0.42250641 |
| 80 | ABL2 | 0.37573365 |
| 81 | GRK5 | 0.36793906 |
| 82 | AKT3 | 0.36761022 |
| 83 | ALK | 0.36444555 |
| 84 | ATR | 0.36315319 |
| 85 | CSK | 0.36081428 |
| 86 | ADRBK1 | 0.35949417 |
| 87 | ZAP70 | 0.35079823 |
| 88 | CSNK1G1 | 0.34358272 |
| 89 | SIK3 | 0.34339467 |
| 90 | INSR | 0.33275544 |
| 91 | CSNK2A1 | 0.33164467 |
| 92 | RPS6KA4 | 0.32797903 |
| 93 | MKNK2 | 0.31108460 |
| 94 | CAMK2G | 0.28227773 |
| 95 | EGFR | 0.27888308 |
| 96 | AURKA | 0.27730642 |
| 97 | MAPK13 | 0.26511094 |
| 98 | GRK7 | 0.26371295 |
| 99 | PAK4 | 0.25065055 |
| 100 | PRKCA | 0.24609930 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 6.19008719 |
| 2 | Primary immunodeficiency_Homo sapiens_hsa05340 | 4.18438513 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.80782126 |
| 4 | Asthma_Homo sapiens_hsa05310 | 2.71378775 |
| 5 | Allograft rejection_Homo sapiens_hsa05330 | 2.66701590 |
| 6 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.65017512 |
| 7 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.29066689 |
| 8 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.25337744 |
| 9 | Parkinsons disease_Homo sapiens_hsa05012 | 2.22919773 |
| 10 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.10414240 |
| 11 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.07125576 |
| 12 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.89310060 |
| 13 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.85731502 |
| 14 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.85204783 |
| 15 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.76937334 |
| 16 | RNA polymerase_Homo sapiens_hsa03020 | 1.65679268 |
| 17 | Protein export_Homo sapiens_hsa03060 | 1.60633856 |
| 18 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.53825849 |
| 19 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.53596642 |
| 20 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.46464473 |
| 21 | Alzheimers disease_Homo sapiens_hsa05010 | 1.43629509 |
| 22 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.41281661 |
| 23 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.40769723 |
| 24 | Huntingtons disease_Homo sapiens_hsa05016 | 1.35678681 |
| 25 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.32988006 |
| 26 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.28165511 |
| 27 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.24427984 |
| 28 | Ribosome_Homo sapiens_hsa03010 | 1.23851901 |
| 29 | Homologous recombination_Homo sapiens_hsa03440 | 1.23773558 |
| 30 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.20472254 |
| 31 | RNA degradation_Homo sapiens_hsa03018 | 1.19741615 |
| 32 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.14238432 |
| 33 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.13703952 |
| 34 | Peroxisome_Homo sapiens_hsa04146 | 1.13657140 |
| 35 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.11034986 |
| 36 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.09811371 |
| 37 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.09259363 |
| 38 | Phototransduction_Homo sapiens_hsa04744 | 1.04881782 |
| 39 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.04692974 |
| 40 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.04585678 |
| 41 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.02814406 |
| 42 | Mismatch repair_Homo sapiens_hsa03430 | 1.02723628 |
| 43 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.01497349 |
| 44 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.97165243 |
| 45 | Base excision repair_Homo sapiens_hsa03410 | 0.97012587 |
| 46 | Measles_Homo sapiens_hsa05162 | 0.95853406 |
| 47 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.95654147 |
| 48 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.93205292 |
| 49 | Basal transcription factors_Homo sapiens_hsa03022 | 0.91510500 |
| 50 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.90898620 |
| 51 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.90673243 |
| 52 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.89651027 |
| 53 | Purine metabolism_Homo sapiens_hsa00230 | 0.85932633 |
| 54 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.80993546 |
| 55 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.80938904 |
| 56 | Shigellosis_Homo sapiens_hsa05131 | 0.79524167 |
| 57 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.79489533 |
| 58 | DNA replication_Homo sapiens_hsa03030 | 0.78127443 |
| 59 | Viral myocarditis_Homo sapiens_hsa05416 | 0.77053787 |
| 60 | Spliceosome_Homo sapiens_hsa03040 | 0.75520592 |
| 61 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.73300324 |
| 62 | RNA transport_Homo sapiens_hsa03013 | 0.72347076 |
| 63 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.71397836 |
| 64 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.68037529 |
| 65 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.64677727 |
| 66 | Olfactory transduction_Homo sapiens_hsa04740 | 0.62155270 |
| 67 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.60043958 |
| 68 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.59392254 |
| 69 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.58081711 |
| 70 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.56810978 |
| 71 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.56688674 |
| 72 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.55599250 |
| 73 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.55407460 |
| 74 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.53396117 |
| 75 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.53141062 |
| 76 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.50947779 |
| 77 | Retinol metabolism_Homo sapiens_hsa00830 | 0.50780775 |
| 78 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.49103694 |
| 79 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.48754079 |
| 80 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.46427952 |
| 81 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.45496598 |
| 82 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.44649825 |
| 83 | Metabolic pathways_Homo sapiens_hsa01100 | 0.41951841 |
| 84 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.39682475 |
| 85 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.38053236 |
| 86 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.35706630 |
| 87 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.35020328 |
| 88 | Circadian rhythm_Homo sapiens_hsa04710 | 0.34064932 |
| 89 | Sulfur relay system_Homo sapiens_hsa04122 | 0.33965578 |
| 90 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.32163761 |
| 91 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.30684971 |
| 92 | Malaria_Homo sapiens_hsa05144 | 0.27872599 |
| 93 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.27829780 |
| 94 | Taste transduction_Homo sapiens_hsa04742 | 0.27547346 |
| 95 | ABC transporters_Homo sapiens_hsa02010 | 0.24559021 |
| 96 | Salmonella infection_Homo sapiens_hsa05132 | 0.24308080 |
| 97 | HTLV-I infection_Homo sapiens_hsa05166 | 0.23802929 |
| 98 | Legionellosis_Homo sapiens_hsa05134 | 0.23381389 |
| 99 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.22879214 |
| 100 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.21596496 |

