PHBP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of isotype switching to IgG isotypes (GO:0048302)8.17706697
2positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)7.89670804
3regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)7.12407819
4regulation of immunoglobulin secretion (GO:0051023)6.78348896
5positive regulation of isotype switching (GO:0045830)5.95365001
6regulation of regulatory T cell differentiation (GO:0045589)5.78796150
7positive regulation of DNA recombination (GO:0045911)5.53909832
8termination of RNA polymerase I transcription (GO:0006363)4.92243057
9proteasome assembly (GO:0043248)4.90364745
10regulation of podosome assembly (GO:0071801)4.88128499
11positive regulation of immunoglobulin production (GO:0002639)4.88061880
12negative regulation of B cell apoptotic process (GO:0002903)4.85542994
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.26791332
14regulation of chronic inflammatory response (GO:0002676)4.21146982
15transcription elongation from RNA polymerase III promoter (GO:0006385)4.08034093
16termination of RNA polymerase III transcription (GO:0006386)4.08034093
17regulation of isotype switching (GO:0045191)4.07640619
18transcription elongation from RNA polymerase I promoter (GO:0006362)4.04526142
19T-helper cell differentiation (GO:0042093)4.02515889
20CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.02515889
21transcription from RNA polymerase I promoter (GO:0006360)3.99222836
22peptidyl-histidine modification (GO:0018202)3.96469684
23positive regulation of interleukin-17 production (GO:0032740)3.94836516
24positive regulation of B cell proliferation (GO:0030890)3.83761584
25regulation of RIG-I signaling pathway (GO:0039535)3.81874495
26positive regulation of immunoglobulin mediated immune response (GO:0002891)3.71454766
27positive regulation of B cell mediated immunity (GO:0002714)3.71454766
28transcription initiation from RNA polymerase I promoter (GO:0006361)3.70016498
29ribosome biogenesis (GO:0042254)3.67599784
30regulation of immunoglobulin production (GO:0002637)3.65463837
31water-soluble vitamin biosynthetic process (GO:0042364)3.59638591
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59297944
33positive regulation of granulocyte differentiation (GO:0030854)3.50371653
34alpha-beta T cell differentiation involved in immune response (GO:0002293)3.49608840
35alpha-beta T cell activation involved in immune response (GO:0002287)3.49608840
36T cell differentiation involved in immune response (GO:0002292)3.49608840
37regulation of cellular amino acid metabolic process (GO:0006521)3.46663419
38regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.43074177
39DNA damage response, detection of DNA damage (GO:0042769)3.42447657
40CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.38270508
41negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.38082464
42CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.36043565
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.36025799
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.36025799
45ATP synthesis coupled proton transport (GO:0015986)3.34789082
46energy coupled proton transport, down electrochemical gradient (GO:0015985)3.34789082
47iron ion import (GO:0097286)3.33629389
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.30362103
49negative regulation of ligase activity (GO:0051352)3.29384800
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.29384800
51positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.21020892
52protein K6-linked ubiquitination (GO:0085020)3.19682837
53rRNA modification (GO:0000154)3.19130689
54maturation of SSU-rRNA (GO:0030490)3.19083859
55polarized epithelial cell differentiation (GO:0030859)3.18006381
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.17433097
57mitochondrial respiratory chain complex I assembly (GO:0032981)3.17433097
58NADH dehydrogenase complex assembly (GO:0010257)3.17433097
59kynurenine metabolic process (GO:0070189)3.14782881
60CD4-positive, alpha-beta T cell activation (GO:0035710)3.10747781
61protein complex biogenesis (GO:0070271)3.09510749
62DNA double-strand break processing (GO:0000729)3.09383059
63GTP biosynthetic process (GO:0006183)3.06769234
64negative regulation of heart rate (GO:0010459)3.06336365
65mitochondrial respiratory chain complex assembly (GO:0033108)3.05752187
66regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.05664657
67positive regulation of activated T cell proliferation (GO:0042104)3.05024138
68negative regulation of T-helper cell differentiation (GO:0045623)3.01000398
69negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.01000398
70tryptophan metabolic process (GO:0006568)3.00996678
71DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99836618
72ribonucleoprotein complex biogenesis (GO:0022613)2.98241198
73hormone catabolic process (GO:0042447)2.98236766
74rRNA processing (GO:0006364)2.98208834
75alpha-beta T cell differentiation (GO:0046632)2.94327256
76folic acid-containing compound biosynthetic process (GO:0009396)2.93973568
77cullin deneddylation (GO:0010388)2.93895482
78cellular component biogenesis (GO:0044085)2.93705805
79protein targeting to mitochondrion (GO:0006626)2.93379691
80signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.93176692
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.93176692
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.93176692
83pseudouridine synthesis (GO:0001522)2.92997724
84exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.92287411
85intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.91535249
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.91535249
87negative regulation of heart contraction (GO:0045822)2.90222130
88rRNA metabolic process (GO:0016072)2.90118085
89signal transduction involved in cell cycle checkpoint (GO:0072395)2.88774723
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87747400
91chaperone-mediated protein transport (GO:0072321)2.87632178
92behavioral response to nicotine (GO:0035095)2.87275782
93signal transduction involved in DNA damage checkpoint (GO:0072422)2.83100269
94signal transduction involved in DNA integrity checkpoint (GO:0072401)2.83100269
95positive regulation of hormone biosynthetic process (GO:0046886)2.80416727
96positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)2.79637568
97DNA deamination (GO:0045006)2.79246317
98anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.78946346
99tRNA processing (GO:0008033)2.77942496
100negative regulation of acute inflammatory response (GO:0002674)2.77503764

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.24408696
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.65096680
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.55555808
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.05085676
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.82190104
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.48253092
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.32198404
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.14642776
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.14219041
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.08560391
11VDR_23849224_ChIP-Seq_CD4+_Human2.95595792
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79745759
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.78596841
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.62445654
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.56714422
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.43508055
17DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.30281169
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.24569044
19DCP1A_22483619_ChIP-Seq_HELA_Human2.20202841
20FOXP3_21729870_ChIP-Seq_TREG_Human2.13713235
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08187541
22MYC_18358816_ChIP-ChIP_MESCs_Mouse1.99693651
23MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99281911
24YY1_21170310_ChIP-Seq_MESCs_Mouse1.77766824
25XRN2_22483619_ChIP-Seq_HELA_Human1.77335030
26GABP_19822575_ChIP-Seq_HepG2_Human1.76314410
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74740889
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74180581
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66963323
30ELK1_19687146_ChIP-ChIP_HELA_Human1.66504392
31ZNF274_21170338_ChIP-Seq_K562_Hela1.65708179
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65654874
33LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65127746
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63587142
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.61841819
36VDR_22108803_ChIP-Seq_LS180_Human1.58917956
37TTF2_22483619_ChIP-Seq_HELA_Human1.58641559
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54053146
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52517154
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49193881
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.44346196
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41253929
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40511824
44EWS_26573619_Chip-Seq_HEK293_Human1.37692754
45TAF15_26573619_Chip-Seq_HEK293_Human1.34185114
46TP53_22573176_ChIP-Seq_HFKS_Human1.32206230
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.26910335
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25922760
49MYC_18940864_ChIP-ChIP_HL60_Human1.22691779
50E2F7_22180533_ChIP-Seq_HELA_Human1.19744946
51PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.19180969
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18476044
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16282933
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14249713
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12048192
56BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07171090
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06140413
58P53_21459846_ChIP-Seq_SAOS-2_Human1.04563509
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04208111
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03891529
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03694642
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.02842249
63E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01717529
64ERA_21632823_ChIP-Seq_H3396_Human1.01414594
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00093868
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99947075
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98957395
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98951018
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98880613
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98619803
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96631508
72STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94837434
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94588995
74MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92592466
75ELK1_22589737_ChIP-Seq_MCF10A_Human0.92232155
76CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92058985
77HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90729632
78AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90685514
79FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87945208
80NANOG_20526341_ChIP-Seq_ESCs_Human0.87219078
81SA1_27219007_Chip-Seq_Bcells_Human0.86551974
82NCOR_22424771_ChIP-Seq_293T_Human0.86422015
83MYC_19829295_ChIP-Seq_ESCs_Human0.84646110
84E2F1_20622854_ChIP-Seq_HELA_Human0.84105154
85SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83259225
86PHF8_20622853_ChIP-Seq_HELA_Human0.83033657
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82944752
88EZH2_27294783_Chip-Seq_NPCs_Mouse0.82224577
89GATA6_21074721_ChIP-Seq_CACO-2_Human0.80977234
90SOX2_19829295_ChIP-Seq_ESCs_Human0.80691424
91NANOG_19829295_ChIP-Seq_ESCs_Human0.80691424
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.80455928
93EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.77661322
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77024720
95MYCN_18555785_ChIP-Seq_MESCs_Mouse0.75751205
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74307520
97GATA3_26560356_Chip-Seq_TH2_Human0.73992723
98FOXP1_21924763_ChIP-Seq_HESCs_Human0.73794848
99GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.73674965
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.73157491

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system4.71570741
2MP0001873_stomach_inflammation4.50489891
3MP0004147_increased_porphyrin_level4.13245612
4MP0000604_amyloidosis3.39575282
5MP0003718_maternal_effect3.32661387
6MP0008875_abnormal_xenobiotic_pharmacok2.99448010
7MP0008872_abnormal_physiological_respon2.97088767
8MP0001835_abnormal_antigen_presentation2.72462186
9MP0003941_abnormal_skin_development2.71455203
10MP0001348_abnormal_lacrimal_gland2.41005765
11MP0001502_abnormal_circadian_rhythm2.28162365
12MP0000465_gastrointestinal_hemorrhage2.27264535
13MP0001853_heart_inflammation2.20768599
14MP0005645_abnormal_hypothalamus_physiol2.17495147
15MP0001879_abnormal_lymphatic_vessel2.06946050
16MP0002254_reproductive_system_inflammat2.05796387
17MP0003300_gastrointestinal_ulcer1.95844856
18MP0002234_abnormal_pharynx_morphology1.93956759
19MP0005084_abnormal_gallbladder_morpholo1.85313587
20MP0003283_abnormal_digestive_organ1.81451998
21MP0005167_abnormal_blood-brain_barrier1.77530954
22MP0002638_abnormal_pupillary_reflex1.76116454
23MP0003693_abnormal_embryo_hatching1.75884063
24MP0000372_irregular_coat_pigmentation1.73255167
25MP0006036_abnormal_mitochondrial_physio1.72714905
26MP0003786_premature_aging1.69804406
27MP0006082_CNS_inflammation1.67829278
28MP0003329_amyloid_beta_deposits1.61522846
29MP0009697_abnormal_copulation1.60672889
30MP0004782_abnormal_surfactant_physiolog1.59649134
31MP0002138_abnormal_hepatobiliary_system1.53529503
32MP0002876_abnormal_thyroid_physiology1.47139488
33MP0004142_abnormal_muscle_tone1.45225481
34MP0001881_abnormal_mammary_gland1.41680080
35MP0002277_abnormal_respiratory_mucosa1.41446252
36MP0002160_abnormal_reproductive_system1.38263587
37MP0005310_abnormal_salivary_gland1.37942370
38MP0003763_abnormal_thymus_physiology1.37915289
39MP0001790_abnormal_immune_system1.37539111
40MP0005387_immune_system_phenotype1.37539111
41MP0009333_abnormal_splenocyte_physiolog1.34629417
42MP0004043_abnormal_pH_regulation1.33232771
43MP0003646_muscle_fatigue1.32527102
44MP0003186_abnormal_redox_activity1.29298712
45MP0003806_abnormal_nucleotide_metabolis1.27821571
46MP0006035_abnormal_mitochondrial_morpho1.24947681
47MP0008058_abnormal_DNA_repair1.20138329
48MP0006276_abnormal_autonomic_nervous1.19210406
49MP0002163_abnormal_gland_morphology1.18265356
50MP0001905_abnormal_dopamine_level1.17265198
51MP0002148_abnormal_hypersensitivity_rea1.15581510
52MP0003656_abnormal_erythrocyte_physiolo1.13489320
53MP0005395_other_phenotype1.07774871
54MP0004084_abnormal_cardiac_muscle1.05520253
55MP0006292_abnormal_olfactory_placode1.03919175
56MP0009046_muscle_twitch0.99491881
57MP0001958_emphysema0.98329818
58MP0002751_abnormal_autonomic_nervous0.97917482
59MP0001529_abnormal_vocalization0.96608378
60MP0003567_abnormal_fetal_cardiomyocyte0.94660315
61MP0001663_abnormal_digestive_system0.93578736
62MP0001986_abnormal_taste_sensitivity0.93201489
63MP0002928_abnormal_bile_duct0.91508702
64MP0003866_abnormal_defecation0.90939951
65MP0005379_endocrine/exocrine_gland_phen0.90701416
66MP0004145_abnormal_muscle_electrophysio0.90403900
67MP0009745_abnormal_behavioral_response0.89899758
68MP0004381_abnormal_hair_follicle0.89641695
69MP0003252_abnormal_bile_duct0.89041519
70MP0003385_abnormal_body_wall0.88172060
71MP0000749_muscle_degeneration0.87853087
72MP0003936_abnormal_reproductive_system0.87621507
73MP0001800_abnormal_humoral_immune0.86876043
74MP0003303_peritoneal_inflammation0.86841394
75MP0002796_impaired_skin_barrier0.84295109
76MP0002693_abnormal_pancreas_physiology0.83675573
77MP0000627_abnormal_mammary_gland0.82211868
78MP0002405_respiratory_system_inflammati0.81670858
79MP0004957_abnormal_blastocyst_morpholog0.81548098
80MP0004885_abnormal_endolymph0.81479298
81MP0005671_abnormal_response_to0.81377492
82MP0000470_abnormal_stomach_morphology0.81223816
83MP0001984_abnormal_olfaction0.79995651
84MP0010094_abnormal_chromosome_stability0.78895059
85MP0005381_digestive/alimentary_phenotyp0.73123283
86MP0002938_white_spotting0.71364703
87MP0000747_muscle_weakness0.70964170
88MP0005551_abnormal_eye_electrophysiolog0.70512278
89MP0001968_abnormal_touch/_nociception0.70346078
90MP0001188_hyperpigmentation0.69636060
91MP0005319_abnormal_enzyme/_coenzyme0.68746744
92MP0004036_abnormal_muscle_relaxation0.68165981
93MP0005332_abnormal_amino_acid0.67188518
94MP0004215_abnormal_myocardial_fiber0.65126596
95MP0003119_abnormal_digestive_system0.64062431
96MP0005171_absent_coat_pigmentation0.63763365
97MP0002166_altered_tumor_susceptibility0.63760344
98MP0002006_tumorigenesis0.62979691
99MP0003011_delayed_dark_adaptation0.61420731
100MP0005330_cardiomyopathy0.61263760

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)5.84458411
2Lipid accumulation in hepatocytes (HP:0006561)5.57038069
3Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.99789358
4Renal Fanconi syndrome (HP:0001994)4.34888410
5Testicular atrophy (HP:0000029)4.29785573
6Mitochondrial inheritance (HP:0001427)4.22061001
7Exertional dyspnea (HP:0002875)4.15021102
83-Methylglutaconic aciduria (HP:0003535)4.13513979
9Acute necrotizing encephalopathy (HP:0006965)3.98249869
10Increased CSF lactate (HP:0002490)3.93994067
11Increased intramyocellular lipid droplets (HP:0012240)3.93222106
12Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.73018983
13Acute encephalopathy (HP:0006846)3.62493119
14Increased muscle lipid content (HP:0009058)3.56745890
15Abnormal mitochondria in muscle tissue (HP:0008316)3.53402628
16Increased serum lactate (HP:0002151)3.50670504
17Hepatocellular necrosis (HP:0001404)3.50471066
18Cerebral hypomyelination (HP:0006808)3.40459300
19Progressive macrocephaly (HP:0004481)3.19743010
20Hypoplasia of the pons (HP:0012110)3.06551489
21Type II lissencephaly (HP:0007260)3.01695434
22Hepatic necrosis (HP:0002605)2.99360602
23Microvesicular hepatic steatosis (HP:0001414)2.98064798
24Abnormality of the pons (HP:0007361)2.95447973
25Respiratory difficulties (HP:0002880)2.95054136
26Malignant hyperthermia (HP:0002047)2.91765981
27Aplastic anemia (HP:0001915)2.82682473
28Decreased electroretinogram (ERG) amplitude (HP:0000654)2.78182722
29Dyschromatopsia (HP:0007641)2.77955644
30Abnormal biliary tract physiology (HP:0012439)2.75956245
31Bile duct proliferation (HP:0001408)2.75956245
32Progressive muscle weakness (HP:0003323)2.73252759
33Exercise intolerance (HP:0003546)2.71909932
34Hyperphosphaturia (HP:0003109)2.71240499
35Optic disc pallor (HP:0000543)2.60562957
36Cerebellar dysplasia (HP:0007033)2.56988428
37Cerebral hemorrhage (HP:0001342)2.53076448
38Mesangial abnormality (HP:0001966)2.52428154
39Elevated erythrocyte sedimentation rate (HP:0003565)2.50493159
40Abnormality of the ileum (HP:0001549)2.49475153
41Hypoalbuminemia (HP:0003073)2.48352522
42Abnormal albumin level (HP:0012116)2.48352522
43Stomatitis (HP:0010280)2.48091379
44Pancreatic cysts (HP:0001737)2.47369511
45Shoulder girdle muscle weakness (HP:0003547)2.46224790
46Focal motor seizures (HP:0011153)2.45252651
47Abnormal urine phosphate concentration (HP:0012599)2.42320371
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.41818190
49Large for gestational age (HP:0001520)2.38101253
50Pelvic girdle muscle weakness (HP:0003749)2.36849784
51Lactic acidosis (HP:0003128)2.36262524
52Meckel diverticulum (HP:0002245)2.32697224
53Abnormality of urine glucose concentration (HP:0011016)2.32627371
54Glycosuria (HP:0003076)2.32627371
55Pendular nystagmus (HP:0012043)2.29350392
56Congenital stationary night blindness (HP:0007642)2.29310057
57Cerebral edema (HP:0002181)2.28933116
58Abnormality of midbrain morphology (HP:0002418)2.28125385
59Molar tooth sign on MRI (HP:0002419)2.28125385
60Absent thumb (HP:0009777)2.26626046
61Neuroendocrine neoplasm (HP:0100634)2.25825912
62Abnormality of renal resorption (HP:0011038)2.21659162
63IgG deficiency (HP:0004315)2.17290350
64Autoimmune hemolytic anemia (HP:0001890)2.16401903
65Colon cancer (HP:0003003)2.12979332
66Neoplasm of head and neck (HP:0012288)2.10467653
67Esophageal neoplasm (HP:0100751)2.10467653
68Chorioretinal atrophy (HP:0000533)2.08117793
69Pancytopenia (HP:0001876)2.07764445
70Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07064800
71Neoplasm of the peripheral nervous system (HP:0100007)2.04892903
72Fatigue (HP:0012378)2.04178137
73Emotional lability (HP:0000712)2.00664129
74Congenital, generalized hypertrichosis (HP:0004540)1.99749300
75Pheochromocytoma (HP:0002666)1.94972401
76Abnormality of the hip-girdle musculature (HP:0001445)1.94023025
77Abnormality of the musculature of the pelvis (HP:0001469)1.94023025
78Premature ovarian failure (HP:0008209)1.93604679
79Respiratory failure (HP:0002878)1.91499005
80Optic nerve coloboma (HP:0000588)1.90871029
81Respiratory insufficiency due to muscle weakness (HP:0002747)1.84996363
82Arthropathy (HP:0003040)1.83290579
83Amniotic constriction ring (HP:0009775)1.82496944
84Abnormality of placental membranes (HP:0011409)1.82496944
85Tubular atrophy (HP:0000092)1.82479163
86Lethargy (HP:0001254)1.80820823
87Abnormality of the preputium (HP:0100587)1.79705813
88Conjunctival hamartoma (HP:0100780)1.75585382
89Progressive inability to walk (HP:0002505)1.74493754
90Attenuation of retinal blood vessels (HP:0007843)1.74459581
91Polydipsia (HP:0001959)1.73639509
92Abnormal drinking behavior (HP:0030082)1.73639509
93Leukodystrophy (HP:0002415)1.72800291
94Renal tubular dysfunction (HP:0000124)1.72162049
95Prolonged partial thromboplastin time (HP:0003645)1.71831573
96Methylmalonic aciduria (HP:0012120)1.70338936
97Squamous cell carcinoma (HP:0002860)1.69218769
98Weak cry (HP:0001612)1.69000920
99Abnormality of the carotid arteries (HP:0005344)1.68925612
100Abnormality of the renal cortex (HP:0011035)1.68449144

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.60844620
2TIE14.34668959
3EIF2AK14.27942393
4TSSK64.25487744
5EIF2AK32.96438794
6BUB12.82564747
7CDK82.75235574
8NUAK12.54647856
9NLK2.32813807
10NME12.31225600
11MST42.19846772
12TEC2.11682709
13FES1.96968197
14ADRBK21.96112769
15PINK11.88951986
16SRPK11.79058113
17MAPKAPK31.73321706
18GRK11.66468357
19TLK11.60101264
20TAOK31.58254927
21TRIM281.55258612
22ZAK1.50463736
23OBSCN1.46625458
24WNK41.45047525
25MAP4K21.42875934
26MAP3K141.40780035
27NME21.36762903
28NEK11.35148371
29PHKG21.31210538
30PHKG11.31210538
31VRK21.31046195
32CCNB11.30611693
33DYRK31.17306344
34SIK31.16993833
35TAOK11.15041774
36AKT31.08049974
37TNIK1.02355287
38PLK31.01335425
39MAPK150.99111769
40CSK0.95279535
41ITK0.95234010
42ACVR1B0.94241378
43STK160.92544329
44STK40.90470393
45TYRO30.86684807
46MAPK130.85359939
47PASK0.85244917
48FER0.83687520
49KIT0.82876978
50TXK0.79532299
51PAK40.76275285
52BMPR1B0.74199044
53FRK0.71331119
54RPS6KA50.70383414
55MUSK0.69604784
56ADRBK10.68830384
57EIF2AK20.68469482
58PLK10.68087661
59TGFBR10.67329506
60MATK0.66955057
61NTRK10.65938096
62VRK10.64268715
63TGFBR20.60856086
64KDR0.58643978
65IKBKB0.58112079
66DMPK0.55936153
67CSNK2A10.53196608
68INSRR0.51940548
69PKN10.50900056
70TYK20.44065013
71ALK0.43257063
72CSNK2A20.42811440
73DYRK20.39122421
74BTK0.38770351
75MAP2K60.38600626
76PIK3CG0.36206908
77MAP3K30.35396556
78IKBKE0.34819336
79CAMK10.34526571
80MKNK20.33768335
81MAPK110.33726352
82CSNK1A10.33719028
83TAOK20.32548458
84PRKG10.32179276
85CHEK20.26988496
86CSNK1A1L0.26666254
87ILK0.25399953
88INSR0.25061253
89AKT20.24697892
90RPS6KB20.24613149
91ATR0.24133109
92PIM20.23401072
93STK390.23325433
94BCR0.22790507
95CSNK1E0.22616419
96WNK10.22119121
97LCK0.22117318
98CSNK1G30.21807557
99PRKCQ0.21135150
100CDK30.20723363

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.69492280
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.21637256
3RNA polymerase_Homo sapiens_hsa030204.09242464
4Oxidative phosphorylation_Homo sapiens_hsa001903.17764543
5Protein export_Homo sapiens_hsa030602.91361517
6Ribosome_Homo sapiens_hsa030102.76319248
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.71492224
8Parkinsons disease_Homo sapiens_hsa050122.65857024
9One carbon pool by folate_Homo sapiens_hsa006702.52554541
10Allograft rejection_Homo sapiens_hsa053302.30595146
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.29290243
12Basal transcription factors_Homo sapiens_hsa030222.25395357
13Autoimmune thyroid disease_Homo sapiens_hsa053202.24516580
14Asthma_Homo sapiens_hsa053102.15659658
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92550913
16Pyrimidine metabolism_Homo sapiens_hsa002401.80472597
17Alzheimers disease_Homo sapiens_hsa050101.76207484
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75451573
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75389117
20Huntingtons disease_Homo sapiens_hsa050161.70809675
21RNA transport_Homo sapiens_hsa030131.63818687
22Spliceosome_Homo sapiens_hsa030401.61204113
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.60971593
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56469860
25Mismatch repair_Homo sapiens_hsa034301.56353816
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46169167
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39373918
28Purine metabolism_Homo sapiens_hsa002301.38352178
29Fanconi anemia pathway_Homo sapiens_hsa034601.33459132
30DNA replication_Homo sapiens_hsa030301.32307060
31RNA degradation_Homo sapiens_hsa030181.27347131
32Cardiac muscle contraction_Homo sapiens_hsa042601.24447205
33Nitrogen metabolism_Homo sapiens_hsa009101.23975354
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.23463301
35Sulfur metabolism_Homo sapiens_hsa009201.21936716
36T cell receptor signaling pathway_Homo sapiens_hsa046601.16810548
37Nucleotide excision repair_Homo sapiens_hsa034201.08106912
38Tryptophan metabolism_Homo sapiens_hsa003801.03266908
39Homologous recombination_Homo sapiens_hsa034401.02100100
40Type I diabetes mellitus_Homo sapiens_hsa049400.97995717
41Hematopoietic cell lineage_Homo sapiens_hsa046400.93656294
42Linoleic acid metabolism_Homo sapiens_hsa005910.92070481
43Selenocompound metabolism_Homo sapiens_hsa004500.90537563
44Graft-versus-host disease_Homo sapiens_hsa053320.89469886
45Primary immunodeficiency_Homo sapiens_hsa053400.83532486
46Dorso-ventral axis formation_Homo sapiens_hsa043200.77191338
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76932932
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76410663
49Caffeine metabolism_Homo sapiens_hsa002320.76077918
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.75933838
51Mineral absorption_Homo sapiens_hsa049780.72199377
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71955453
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71292153
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.70175413
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69706887
56Propanoate metabolism_Homo sapiens_hsa006400.67967128
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.67957588
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67620068
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67286737
60Measles_Homo sapiens_hsa051620.66454515
61Collecting duct acid secretion_Homo sapiens_hsa049660.66106393
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65754349
63Metabolic pathways_Homo sapiens_hsa011000.61983747
64Non-homologous end-joining_Homo sapiens_hsa034500.61108202
65Fat digestion and absorption_Homo sapiens_hsa049750.60708394
66Olfactory transduction_Homo sapiens_hsa047400.59035063
67Glutathione metabolism_Homo sapiens_hsa004800.58062841
68Phototransduction_Homo sapiens_hsa047440.54861894
69Chemical carcinogenesis_Homo sapiens_hsa052040.52093282
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.50060958
71Steroid biosynthesis_Homo sapiens_hsa001000.48905984
72Sulfur relay system_Homo sapiens_hsa041220.47944557
73Arginine and proline metabolism_Homo sapiens_hsa003300.44662798
74mRNA surveillance pathway_Homo sapiens_hsa030150.43598125
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.39511136
76Peroxisome_Homo sapiens_hsa041460.39274810
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38765095
78Base excision repair_Homo sapiens_hsa034100.38402442
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37818378
80Pyruvate metabolism_Homo sapiens_hsa006200.37731674
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35152857
82Rheumatoid arthritis_Homo sapiens_hsa053230.34095540
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31470144
84Circadian rhythm_Homo sapiens_hsa047100.29760297
85Epstein-Barr virus infection_Homo sapiens_hsa051690.27870587
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.26387406
87Retinol metabolism_Homo sapiens_hsa008300.25671170
88Fatty acid degradation_Homo sapiens_hsa000710.25586675
89Arachidonic acid metabolism_Homo sapiens_hsa005900.22482970
90HTLV-I infection_Homo sapiens_hsa051660.22297572
91ABC transporters_Homo sapiens_hsa020100.20639660
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20192637
93Regulation of autophagy_Homo sapiens_hsa041400.19708353
94Vitamin B6 metabolism_Homo sapiens_hsa007500.19491742
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.15401668
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14807323
97Fatty acid biosynthesis_Homo sapiens_hsa000610.12400827
98Carbon metabolism_Homo sapiens_hsa012000.10489674
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.10454811
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.06785340

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