PHBP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1monoubiquitinated protein deubiquitination (GO:0035520)6.47553789
2pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.40342691
3cell morphogenesis involved in neuron differentiation (GO:0048667)5.19851172
4positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.09889380
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.75872265
6regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.72286119
7negative regulation of B cell apoptotic process (GO:0002903)4.55421061
8L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.54627121
9protein neddylation (GO:0045116)4.53680478
10pyrimidine nucleotide catabolic process (GO:0006244)4.50809843
11positive regulation of interleukin-17 production (GO:0032740)4.38083859
12ATP synthesis coupled proton transport (GO:0015986)4.37616118
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.37616118
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.36466743
15mitochondrial respiratory chain complex I assembly (GO:0032981)4.36466743
16NADH dehydrogenase complex assembly (GO:0010257)4.36466743
17water-soluble vitamin biosynthetic process (GO:0042364)4.34591282
18post-embryonic morphogenesis (GO:0009886)4.28745387
19platelet dense granule organization (GO:0060155)4.24244039
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.22598733
21protein complex biogenesis (GO:0070271)4.11395322
22regulation of regulatory T cell differentiation (GO:0045589)3.98276758
23ribosomal small subunit assembly (GO:0000028)3.91275265
24respiratory electron transport chain (GO:0022904)3.90120019
25L-methionine salvage (GO:0071267)3.83818220
26L-methionine biosynthetic process (GO:0071265)3.83818220
27amino acid salvage (GO:0043102)3.83818220
28electron transport chain (GO:0022900)3.80436109
29mitochondrial respiratory chain complex assembly (GO:0033108)3.79760766
30peptidyl-histidine modification (GO:0018202)3.77712002
31chaperone mediated protein folding requiring cofactor (GO:0051085)3.77594573
32synapsis (GO:0007129)3.77436516
33cobalamin metabolic process (GO:0009235)3.68386174
34negative regulation of heart rate (GO:0010459)3.68256332
35regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.60534405
36regulation of hypersensitivity (GO:0002883)3.58170229
37establishment of protein localization to mitochondrial membrane (GO:0090151)3.57698608
38pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.53608382
39base-excision repair, AP site formation (GO:0006285)3.51704412
40regulation of cellular respiration (GO:0043457)3.45934808
41nucleotide transmembrane transport (GO:1901679)3.45265441
42regulation of B cell apoptotic process (GO:0002902)3.40688893
43phosphatidylinositol acyl-chain remodeling (GO:0036149)3.40433267
44serotonin receptor signaling pathway (GO:0007210)3.36731265
45phosphatidylserine acyl-chain remodeling (GO:0036150)3.32366895
46folic acid-containing compound biosynthetic process (GO:0009396)3.28960748
47positive regulation of B cell mediated immunity (GO:0002714)3.25194011
48positive regulation of immunoglobulin mediated immune response (GO:0002891)3.25194011
49folic acid metabolic process (GO:0046655)3.24393555
50positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.18400435
51regulation of isotype switching to IgG isotypes (GO:0048302)3.15767724
52positive regulation of fibroblast migration (GO:0010763)3.14742891
53regulation of immunoglobulin secretion (GO:0051023)3.13724734
54regulation of rhodopsin mediated signaling pathway (GO:0022400)3.12404673
55deoxyribonucleotide catabolic process (GO:0009264)3.09649965
56cell wall macromolecule catabolic process (GO:0016998)3.06040790
57intestinal cholesterol absorption (GO:0030299)3.03616425
58positive regulation of isotype switching (GO:0045830)3.03096874
59resolution of meiotic recombination intermediates (GO:0000712)2.96412758
60phosphatidylcholine acyl-chain remodeling (GO:0036151)2.95966454
61regulation of cellular amino acid metabolic process (GO:0006521)2.94402456
62response to pheromone (GO:0019236)2.93629223
63negative regulation of acute inflammatory response (GO:0002674)2.91640471
64positive regulation of DNA recombination (GO:0045911)2.89968786
65regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.89537307
66positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.87065249
67positive regulation of mast cell degranulation (GO:0043306)2.85708915
68positive regulation of mast cell activation involved in immune response (GO:0033008)2.85708915
69leukotriene biosynthetic process (GO:0019370)2.85656558
70cardiolipin metabolic process (GO:0032048)2.83842864
71deoxyribose phosphate catabolic process (GO:0046386)2.83268322
72signal peptide processing (GO:0006465)2.82067450
73methionine biosynthetic process (GO:0009086)2.82037594
74rhodopsin mediated signaling pathway (GO:0016056)2.82034693
75oogenesis (GO:0048477)2.79816674
76regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.77841379
77S-adenosylmethionine metabolic process (GO:0046500)2.77641336
78regulation of glomerular filtration (GO:0003093)2.77484295
79pteridine-containing compound biosynthetic process (GO:0042559)2.77344974
80signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.74761225
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.74761225
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.74761225
83rRNA modification (GO:0000154)2.74469612
84DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.72412963
85kynurenine metabolic process (GO:0070189)2.72079501
86phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.71895634
87mast cell activation (GO:0045576)2.67346928
88behavioral response to nicotine (GO:0035095)2.66913495
89gamma-aminobutyric acid transport (GO:0015812)2.65129744
90multicellular organism reproduction (GO:0032504)2.64610001
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.63653622
92signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.63653622
93nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.63581528
94proteasome assembly (GO:0043248)2.63101746
95tryptophan catabolic process (GO:0006569)2.61571551
96indole-containing compound catabolic process (GO:0042436)2.61571551
97indolalkylamine catabolic process (GO:0046218)2.61571551
98negative regulation of macroautophagy (GO:0016242)2.60714519
99methionine metabolic process (GO:0006555)2.60448474
100negative regulation of heart contraction (GO:0045822)2.59472299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.36256664
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.24831381
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.62250607
4VDR_22108803_ChIP-Seq_LS180_Human3.35287322
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.99476304
6TAF15_26573619_Chip-Seq_HEK293_Human2.93118812
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.85743132
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80729098
9EWS_26573619_Chip-Seq_HEK293_Human2.70546149
10VDR_23849224_ChIP-Seq_CD4+_Human2.42953606
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.38353429
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31079995
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.30707455
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.30655571
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.27769434
16AUTS2_25519132_ChIP-Seq_293T-REX_Human2.24000871
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.20802996
18ZNF274_21170338_ChIP-Seq_K562_Hela2.04605062
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98541975
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.95257277
21FOXP3_21729870_ChIP-Seq_TREG_Human1.85284138
22EGR1_23403033_ChIP-Seq_LIVER_Mouse1.84997616
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.82983392
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82381362
25PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.73188168
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67236216
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.67102045
28FUS_26573619_Chip-Seq_HEK293_Human1.66811384
29CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.64778463
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.64485289
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63919393
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.58440603
33CBP_20019798_ChIP-Seq_JUKART_Human1.57497073
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57497073
35FOXA1_27270436_Chip-Seq_PROSTATE_Human1.56376019
36FOXA1_25329375_ChIP-Seq_VCAP_Human1.56376019
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53151734
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47412604
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47364453
40EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.42627473
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42561223
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41098386
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.39823892
44GATA3_26560356_Chip-Seq_TH2_Human1.37677578
45AR_20517297_ChIP-Seq_VCAP_Human1.36644996
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33865100
47SOX2_19829295_ChIP-Seq_ESCs_Human1.33690615
48NANOG_19829295_ChIP-Seq_ESCs_Human1.33690615
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32274384
50ER_23166858_ChIP-Seq_MCF-7_Human1.27215230
51GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25299837
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25079125
53FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24526725
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24423716
55MYC_18940864_ChIP-ChIP_HL60_Human1.23925356
56CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.23791930
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23196563
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23053381
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21898126
60P300_19829295_ChIP-Seq_ESCs_Human1.17712849
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17667659
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14939312
63STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14036709
64ELK1_19687146_ChIP-ChIP_HELA_Human1.12848555
65NCOR_22424771_ChIP-Seq_293T_Human1.12784219
66NANOG_20526341_ChIP-Seq_ESCs_Human1.10676478
67SMAD1_18555785_Chip-Seq_ESCs_Mouse1.10359121
68STAT3_18555785_Chip-Seq_ESCs_Mouse1.09504441
69MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09452301
70OCT4_18555785_Chip-Seq_ESCs_Mouse1.06036572
71RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05975729
72TP53_22573176_ChIP-Seq_HFKS_Human1.05899172
73RUNX_20019798_ChIP-Seq_JUKART_Human1.05298724
74P53_22387025_ChIP-Seq_ESCs_Mouse1.04816235
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04484073
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04170413
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.03804167
78SOX2_18555785_Chip-Seq_ESCs_Mouse1.03467353
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02530079
80TAF2_19829295_ChIP-Seq_ESCs_Human1.01848343
81CMYC_18555785_Chip-Seq_ESCs_Mouse0.98622705
82E2F1_20622854_ChIP-Seq_HELA_Human0.98533321
83NMYC_18555785_Chip-Seq_ESCs_Mouse0.98080144
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97284293
85HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96901746
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96198956
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94652794
88P53_21459846_ChIP-Seq_SAOS-2_Human0.94055627
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93840971
90OCT4_20526341_ChIP-Seq_ESCs_Human0.93611784
91GATA3_26560356_Chip-Seq_TH1_Human0.93512936
92MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92958927
93BCAT_22108803_ChIP-Seq_LS180_Human0.92827129
94RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92382445
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92173139
96P300_18555785_Chip-Seq_ESCs_Mouse0.91445911
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90974878
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90948058
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90062316
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89123331

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.47733174
2MP0001835_abnormal_antigen_presentation3.71262621
3MP0004147_increased_porphyrin_level3.57056712
4MP0006072_abnormal_retinal_apoptosis3.05989209
5MP0002837_dystrophic_cardiac_calcinosis2.90601330
6MP0003195_calcinosis2.88711264
7MP0002166_altered_tumor_susceptibility2.72727753
8MP0003011_delayed_dark_adaptation2.55731018
9MP0010386_abnormal_urinary_bladder2.33972282
10MP0003786_premature_aging2.30615601
11MP0002148_abnormal_hypersensitivity_rea2.19205070
12MP0002006_tumorigenesis2.18132914
13MP0000516_abnormal_urinary_system2.14447999
14MP0005367_renal/urinary_system_phenotyp2.14447999
15MP0008875_abnormal_xenobiotic_pharmacok2.11082484
16MP0003718_maternal_effect2.03697040
17MP0001853_heart_inflammation1.99640160
18MP0009764_decreased_sensitivity_to1.97063944
19MP0008995_early_reproductive_senescence1.95293418
20MP0001790_abnormal_immune_system1.91446489
21MP0005387_immune_system_phenotype1.91446489
22MP0001666_abnormal_nutrient_absorption1.90923202
23MP0002876_abnormal_thyroid_physiology1.90826392
24MP0005671_abnormal_response_to1.83260138
25MP0006292_abnormal_olfactory_placode1.80630528
26MP0000465_gastrointestinal_hemorrhage1.68891277
27MP0002736_abnormal_nociception_after1.68751387
28MP0005551_abnormal_eye_electrophysiolog1.65334401
29MP0006036_abnormal_mitochondrial_physio1.64404304
30MP0005085_abnormal_gallbladder_physiolo1.61846827
31MP0005646_abnormal_pituitary_gland1.53587130
32MP0004142_abnormal_muscle_tone1.49327430
33MP0003638_abnormal_response/metabolism_1.43316133
34MP0000685_abnormal_immune_system1.42943287
35MP0002277_abnormal_respiratory_mucosa1.41506761
36MP0005253_abnormal_eye_physiology1.38518834
37MP0001727_abnormal_embryo_implantation1.37760048
38MP0003806_abnormal_nucleotide_metabolis1.35765776
39MP0001800_abnormal_humoral_immune1.34432209
40MP0005365_abnormal_bile_salt1.30041316
41MP0008872_abnormal_physiological_respon1.29598189
42MP0003724_increased_susceptibility_to1.29372703
43MP0003136_yellow_coat_color1.29167848
44MP0000538_abnormal_urinary_bladder1.28490025
45MP0001968_abnormal_touch/_nociception1.24877377
46MP0001905_abnormal_dopamine_level1.24589461
47MP0005670_abnormal_white_adipose1.22556579
48MP0003878_abnormal_ear_physiology1.22119531
49MP0005377_hearing/vestibular/ear_phenot1.22119531
50MP0002160_abnormal_reproductive_system1.22050995
51MP0004043_abnormal_pH_regulation1.15686206
52MP0005389_reproductive_system_phenotype1.15328574
53MP0003567_abnormal_fetal_cardiomyocyte1.07967313
54MP0002139_abnormal_hepatobiliary_system1.05635397
55MP0005332_abnormal_amino_acid1.03027455
56MP0003300_gastrointestinal_ulcer1.01122815
57MP0005084_abnormal_gallbladder_morpholo1.00964003
58MP0002095_abnormal_skin_pigmentation0.97383217
59MP0002723_abnormal_immune_serum0.94691090
60MP0005397_hematopoietic_system_phenotyp0.94354150
61MP0001545_abnormal_hematopoietic_system0.94354150
62MP0000427_abnormal_hair_cycle0.93271667
63MP0003950_abnormal_plasma_membrane0.92673082
64MP0001764_abnormal_homeostasis0.92129146
65MP0009785_altered_susceptibility_to0.90274594
66MP0005000_abnormal_immune_tolerance0.88997163
67MP0001919_abnormal_reproductive_system0.88968707
68MP0005645_abnormal_hypothalamus_physiol0.86706726
69MP0010329_abnormal_lipoprotein_level0.86048876
70MP0008469_abnormal_protein_level0.85595334
71MP0002452_abnormal_antigen_presenting0.84464772
72MP0003075_altered_response_to0.84073356
73MP0001501_abnormal_sleep_pattern0.83697679
74MP0005647_abnormal_sex_gland0.82457161
75MP0005165_increased_susceptibility_to0.81230835
76MP0001485_abnormal_pinna_reflex0.81205801
77MP0005319_abnormal_enzyme/_coenzyme0.81148646
78MP0003763_abnormal_thymus_physiology0.80053664
79MP0004130_abnormal_muscle_cell0.79961186
80MP0002733_abnormal_thermal_nociception0.79253653
81MP0000604_amyloidosis0.77126160
82MP0001986_abnormal_taste_sensitivity0.76519002
83MP0003252_abnormal_bile_duct0.76281009
84MP0001293_anophthalmia0.75001591
85MP0002420_abnormal_adaptive_immunity0.74824329
86MP0000639_abnormal_adrenal_gland0.74284677
87MP0001819_abnormal_immune_cell0.73093162
88MP0005025_abnormal_response_to0.73045039
89MP0001845_abnormal_inflammatory_respons0.72996639
90MP0005636_abnormal_mineral_homeostasis0.72326195
91MP0005410_abnormal_fertilization0.72040790
92MP0009046_muscle_twitch0.71366230
93MP0002332_abnormal_exercise_endurance0.70371331
94MP0001529_abnormal_vocalization0.70169393
95MP0001970_abnormal_pain_threshold0.69201176
96MP0005535_abnormal_body_temperature0.69108618
97MP0003172_abnormal_lysosome_physiology0.69045599
98MP0004885_abnormal_endolymph0.67914027
99MP0000343_altered_response_to0.66815544
100MP0004019_abnormal_vitamin_homeostasis0.65848342

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)7.76391305
2Hyperalaninemia (HP:0003348)7.76391305
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)7.76391305
4Congenital stationary night blindness (HP:0007642)6.94451950
53-Methylglutaconic aciduria (HP:0003535)6.82702675
6Congenital, generalized hypertrichosis (HP:0004540)5.15896841
7Agammaglobulinemia (HP:0004432)4.95706797
8Hyperglycinemia (HP:0002154)4.21393198
9Abnormality of serum amino acid levels (HP:0003112)4.15518193
10Methylmalonic acidemia (HP:0002912)4.04649190
11Acute necrotizing encephalopathy (HP:0006965)3.53457187
12Cutaneous melanoma (HP:0012056)3.49775039
13Prostate neoplasm (HP:0100787)3.28593313
14Abnormal mitochondria in muscle tissue (HP:0008316)3.23979768
15Mitochondrial inheritance (HP:0001427)3.18323858
16Hepatic necrosis (HP:0002605)3.17582586
17Progressive macrocephaly (HP:0004481)3.15472159
18Nausea (HP:0002018)3.15220703
19Increased CSF lactate (HP:0002490)3.12656984
20Methylmalonic aciduria (HP:0012120)3.08728642
21Hepatocellular necrosis (HP:0001404)3.07476014
22Acute encephalopathy (HP:0006846)2.94966397
23IgG deficiency (HP:0004315)2.93390315
24Chronic sinusitis (HP:0011109)2.89716382
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.88082816
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.88082816
27Microretrognathia (HP:0000308)2.83960370
28Abnormality of the vitamin B12 metabolism (HP:0004341)2.80842249
29Elevated erythrocyte sedimentation rate (HP:0003565)2.78533095
30Increased serum lactate (HP:0002151)2.72947172
31Abnormality of vitamin B metabolism (HP:0004340)2.61416553
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.59580836
33Lactic acidosis (HP:0003128)2.53735356
34Type I transferrin isoform profile (HP:0003642)2.53649037
35Abnormality of midbrain morphology (HP:0002418)2.42520115
36Molar tooth sign on MRI (HP:0002419)2.42520115
37Recurrent bronchitis (HP:0002837)2.39937590
38Proximal tubulopathy (HP:0000114)2.38931384
39Spastic paraparesis (HP:0002313)2.38848631
40Persistence of primary teeth (HP:0006335)2.37283172
41Hypoplasia of the fovea (HP:0007750)2.34185980
42Aplasia/Hypoplasia of the fovea (HP:0008060)2.34185980
43Supernumerary spleens (HP:0009799)2.32825961
44Testicular atrophy (HP:0000029)2.31015587
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.28601956
46Progressive external ophthalmoplegia (HP:0000590)2.28186259
47Abnormality of the proximal phalanges of the hand (HP:0009834)2.28092844
48Cellular immunodeficiency (HP:0005374)2.23099248
49Hyperammonemia (HP:0001987)2.19926021
50Dicarboxylic aciduria (HP:0003215)2.17287655
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17287655
52Clumsiness (HP:0002312)2.15779060
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.15588182
54Delayed CNS myelination (HP:0002188)2.14589593
55Generalized aminoaciduria (HP:0002909)2.12743667
56Leukodystrophy (HP:0002415)2.11588083
57Sensorimotor neuropathy (HP:0007141)2.10110337
58Aplastic anemia (HP:0001915)2.09686799
59Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07903740
60Nephronophthisis (HP:0000090)2.04110773
61Abolished electroretinogram (ERG) (HP:0000550)2.01255062
62Cerebral edema (HP:0002181)2.00635333
63Abnormality of the prostate (HP:0008775)1.94994163
64Abnormal spermatogenesis (HP:0008669)1.94915905
65Stomatitis (HP:0010280)1.94196971
66Exercise intolerance (HP:0003546)1.93987667
67Azoospermia (HP:0000027)1.92864201
68Lethargy (HP:0001254)1.92769557
69Respiratory failure (HP:0002878)1.90329166
70Progressive inability to walk (HP:0002505)1.90302108
71Reduced antithrombin III activity (HP:0001976)1.89111949
72Abnormality of glycine metabolism (HP:0010895)1.88651314
73Abnormality of serine family amino acid metabolism (HP:0010894)1.88651314
74Hydroureter (HP:0000072)1.87746503
75Increased serum ferritin (HP:0003281)1.87483849
76Optic disc pallor (HP:0000543)1.84930049
77Increased intramyocellular lipid droplets (HP:0012240)1.84154518
78Flat face (HP:0012368)1.83776559
79Vacuolated lymphocytes (HP:0001922)1.82647119
80Ketosis (HP:0001946)1.81811675
81Panhypogammaglobulinemia (HP:0003139)1.80078599
82Abnormality of vitamin metabolism (HP:0100508)1.79602832
83Abnormality of the middle phalanges of the toes (HP:0010183)1.79007846
84Glucose intolerance (HP:0000833)1.76843147
85Flared iliac wings (HP:0002869)1.76284961
86Encephalitis (HP:0002383)1.74689134
87Increased hepatocellular lipid droplets (HP:0006565)1.74505548
88Pancreatic cysts (HP:0001737)1.73701515
89Recurrent cutaneous fungal infections (HP:0011370)1.73500155
90Chronic mucocutaneous candidiasis (HP:0002728)1.73500155
91Lipid accumulation in hepatocytes (HP:0006561)1.70600637
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70265967
93Abnormal protein N-linked glycosylation (HP:0012347)1.70265967
94Abnormal protein glycosylation (HP:0012346)1.70265967
95Abnormal glycosylation (HP:0012345)1.70265967
96Abnormality of iron homeostasis (HP:0011031)1.67267696
97Abnormal rod and cone electroretinograms (HP:0008323)1.67236422
98Papilloma (HP:0012740)1.66614042
99Verrucae (HP:0200043)1.66614042
100Abnormal glucose tolerance (HP:0001952)1.65655010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK29.39020746
2GRK14.84918255
3ZAK3.38950572
4TIE13.08064110
5EIF2AK12.77915763
6FRK2.72816728
7TAF12.59390828
8MAPKAPK52.55448789
9MKNK12.51526599
10CDC72.38165700
11NME12.01371064
12TXK1.99852869
13PDK21.68752332
14TLK11.67943840
15MAP3K131.67793028
16SIK31.50275174
17VRK21.45251631
18NUAK11.39840636
19TEC1.30840820
20TRPM71.29174191
21EIF2AK31.23656825
22MAPKAPK31.23354219
23MAP3K141.19241483
24KIT1.16023631
25LYN1.15904301
26WNK41.13407813
27NME21.08013708
28MST40.97983097
29ACVR1B0.96404245
30MAP4K10.94580670
31ITK0.86249497
32DAPK10.85852654
33VRK10.84086807
34RPS6KA50.82503761
35TYK20.81891528
36SYK0.77502391
37TSSK60.77412817
38STK160.75393061
39ADRBK20.74752029
40TNK20.73479128
41SMG10.71099363
42PLK30.69250009
43IRAK40.66071907
44MAP3K120.65380936
45EGFR0.63218878
46MYLK0.62120600
47OXSR10.61903275
48PLK40.58397492
49STK390.58018976
50PRKAA20.55436426
51LCK0.55046124
52HCK0.53386352
53MAP4K20.53090330
54INSRR0.52852055
55CSK0.52593144
56ERBB30.52544139
57BCKDK0.50721763
58IKBKB0.50473938
59BMPR20.48376743
60AKT20.47600448
61CHEK20.44289854
62CAMKK20.43681836
63PAK30.42893835
64MUSK0.42464610
65PRKCE0.41983514
66FLT30.40152024
67AURKB0.39214112
68EIF2AK20.39055284
69MAPK110.37150088
70FGFR20.37111658
71IGF1R0.37078227
72CSNK1G30.36175348
73CSNK2A20.36040866
74MAPK40.35460462
75ATR0.35299593
76CSNK2A10.34507446
77PRKACB0.33940217
78CAMK2A0.33001317
79RPS6KA40.32855489
80PRKACG0.32606552
81CSNK1G20.32252886
82RPS6KB20.30732182
83PLK10.29143744
84CAMK2B0.27763488
85KDR0.26937932
86DAPK30.26904769
87CSNK1A1L0.26904412
88PRKACA0.25821600
89DYRK20.25085608
90CDK70.24134544
91MAP2K60.23901417
92CAMK2G0.23737277
93CSNK1A10.22820087
94BUB10.22691844
95OBSCN0.21654542
96SIK20.21140635
97CSNK1G10.21131507
98INSR0.20740309
99CAMK2D0.20576859
100PAK40.20355054

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.10732502
2Protein export_Homo sapiens_hsa030603.71285927
3Asthma_Homo sapiens_hsa053103.63903370
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.26117409
5Oxidative phosphorylation_Homo sapiens_hsa001902.92254145
6Sulfur metabolism_Homo sapiens_hsa009202.84180532
7Phototransduction_Homo sapiens_hsa047442.65876224
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.49873917
9Parkinsons disease_Homo sapiens_hsa050122.44165982
10Allograft rejection_Homo sapiens_hsa053302.35742546
11Autoimmune thyroid disease_Homo sapiens_hsa053202.27284588
12Linoleic acid metabolism_Homo sapiens_hsa005912.21611164
13Graft-versus-host disease_Homo sapiens_hsa053322.14214231
14Type I diabetes mellitus_Homo sapiens_hsa049402.04272595
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.86285796
16Ribosome_Homo sapiens_hsa030101.81263731
17One carbon pool by folate_Homo sapiens_hsa006701.63434543
18Homologous recombination_Homo sapiens_hsa034401.60817415
19Cardiac muscle contraction_Homo sapiens_hsa042601.60402642
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.58772139
21Hematopoietic cell lineage_Homo sapiens_hsa046401.57434237
22Huntingtons disease_Homo sapiens_hsa050161.55363269
23Alzheimers disease_Homo sapiens_hsa050101.50916006
24Propanoate metabolism_Homo sapiens_hsa006401.48121176
25Caffeine metabolism_Homo sapiens_hsa002321.44014752
26Primary immunodeficiency_Homo sapiens_hsa053401.40165969
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39060945
28Tryptophan metabolism_Homo sapiens_hsa003801.38482865
29Antigen processing and presentation_Homo sapiens_hsa046121.37614009
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.37317595
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.30511303
32Fanconi anemia pathway_Homo sapiens_hsa034601.25465858
33Nitrogen metabolism_Homo sapiens_hsa009101.10534010
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10324216
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07897510
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02247679
37Retinol metabolism_Homo sapiens_hsa008300.98694107
38RNA degradation_Homo sapiens_hsa030180.98476438
39Fat digestion and absorption_Homo sapiens_hsa049750.96565755
40Folate biosynthesis_Homo sapiens_hsa007900.95162288
41RNA polymerase_Homo sapiens_hsa030200.93185969
42Purine metabolism_Homo sapiens_hsa002300.93118493
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89706367
44Mismatch repair_Homo sapiens_hsa034300.89528401
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89366902
46Pyrimidine metabolism_Homo sapiens_hsa002400.89341982
47Rheumatoid arthritis_Homo sapiens_hsa053230.89129983
48Basal transcription factors_Homo sapiens_hsa030220.87661671
49beta-Alanine metabolism_Homo sapiens_hsa004100.86310207
50Pyruvate metabolism_Homo sapiens_hsa006200.85296816
51Base excision repair_Homo sapiens_hsa034100.85056235
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.85048465
53Arachidonic acid metabolism_Homo sapiens_hsa005900.83029219
54Glycerolipid metabolism_Homo sapiens_hsa005610.81152704
55Ether lipid metabolism_Homo sapiens_hsa005650.79921798
56Vitamin digestion and absorption_Homo sapiens_hsa049770.78766278
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78584167
58Chemical carcinogenesis_Homo sapiens_hsa052040.77374768
59Staphylococcus aureus infection_Homo sapiens_hsa051500.74103169
60Spliceosome_Homo sapiens_hsa030400.73750246
61DNA replication_Homo sapiens_hsa030300.72499627
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72138065
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68556099
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.65759441
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65053933
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62914814
67Ovarian steroidogenesis_Homo sapiens_hsa049130.59466036
68Pancreatic secretion_Homo sapiens_hsa049720.59116946
69Metabolic pathways_Homo sapiens_hsa011000.56009100
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55285148
71Phenylalanine metabolism_Homo sapiens_hsa003600.53301359
72Fatty acid elongation_Homo sapiens_hsa000620.52541889
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49971619
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.49291219
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48872590
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.48865706
77Nicotine addiction_Homo sapiens_hsa050330.47317735
78Peroxisome_Homo sapiens_hsa041460.46854788
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46051969
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45948742
81Nucleotide excision repair_Homo sapiens_hsa034200.44011137
82Tyrosine metabolism_Homo sapiens_hsa003500.43096625
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42898477
84Leishmaniasis_Homo sapiens_hsa051400.42705502
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.42440840
86Butanoate metabolism_Homo sapiens_hsa006500.42345379
87Olfactory transduction_Homo sapiens_hsa047400.40898498
88Serotonergic synapse_Homo sapiens_hsa047260.40587025
89Protein digestion and absorption_Homo sapiens_hsa049740.39628397
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38664588
91Fatty acid degradation_Homo sapiens_hsa000710.37848666
92Histidine metabolism_Homo sapiens_hsa003400.35405118
93Sulfur relay system_Homo sapiens_hsa041220.33394713
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31032561
95Other glycan degradation_Homo sapiens_hsa005110.30855670
96Systemic lupus erythematosus_Homo sapiens_hsa053220.30030016
97RNA transport_Homo sapiens_hsa030130.29896555
98Morphine addiction_Homo sapiens_hsa050320.29834620
99Glutathione metabolism_Homo sapiens_hsa004800.25451021
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22791954

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