

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | monoubiquitinated protein deubiquitination (GO:0035520) | 6.47553789 |
| 2 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 5.40342691 |
| 3 | cell morphogenesis involved in neuron differentiation (GO:0048667) | 5.19851172 |
| 4 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 5.09889380 |
| 5 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.75872265 |
| 6 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 4.72286119 |
| 7 | negative regulation of B cell apoptotic process (GO:0002903) | 4.55421061 |
| 8 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 4.54627121 |
| 9 | protein neddylation (GO:0045116) | 4.53680478 |
| 10 | pyrimidine nucleotide catabolic process (GO:0006244) | 4.50809843 |
| 11 | positive regulation of interleukin-17 production (GO:0032740) | 4.38083859 |
| 12 | ATP synthesis coupled proton transport (GO:0015986) | 4.37616118 |
| 13 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.37616118 |
| 14 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.36466743 |
| 15 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.36466743 |
| 16 | NADH dehydrogenase complex assembly (GO:0010257) | 4.36466743 |
| 17 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.34591282 |
| 18 | post-embryonic morphogenesis (GO:0009886) | 4.28745387 |
| 19 | platelet dense granule organization (GO:0060155) | 4.24244039 |
| 20 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.22598733 |
| 21 | protein complex biogenesis (GO:0070271) | 4.11395322 |
| 22 | regulation of regulatory T cell differentiation (GO:0045589) | 3.98276758 |
| 23 | ribosomal small subunit assembly (GO:0000028) | 3.91275265 |
| 24 | respiratory electron transport chain (GO:0022904) | 3.90120019 |
| 25 | L-methionine salvage (GO:0071267) | 3.83818220 |
| 26 | L-methionine biosynthetic process (GO:0071265) | 3.83818220 |
| 27 | amino acid salvage (GO:0043102) | 3.83818220 |
| 28 | electron transport chain (GO:0022900) | 3.80436109 |
| 29 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.79760766 |
| 30 | peptidyl-histidine modification (GO:0018202) | 3.77712002 |
| 31 | chaperone mediated protein folding requiring cofactor (GO:0051085) | 3.77594573 |
| 32 | synapsis (GO:0007129) | 3.77436516 |
| 33 | cobalamin metabolic process (GO:0009235) | 3.68386174 |
| 34 | negative regulation of heart rate (GO:0010459) | 3.68256332 |
| 35 | regulation of acute inflammatory response to antigenic stimulus (GO:0002864) | 3.60534405 |
| 36 | regulation of hypersensitivity (GO:0002883) | 3.58170229 |
| 37 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.57698608 |
| 38 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.53608382 |
| 39 | base-excision repair, AP site formation (GO:0006285) | 3.51704412 |
| 40 | regulation of cellular respiration (GO:0043457) | 3.45934808 |
| 41 | nucleotide transmembrane transport (GO:1901679) | 3.45265441 |
| 42 | regulation of B cell apoptotic process (GO:0002902) | 3.40688893 |
| 43 | phosphatidylinositol acyl-chain remodeling (GO:0036149) | 3.40433267 |
| 44 | serotonin receptor signaling pathway (GO:0007210) | 3.36731265 |
| 45 | phosphatidylserine acyl-chain remodeling (GO:0036150) | 3.32366895 |
| 46 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.28960748 |
| 47 | positive regulation of B cell mediated immunity (GO:0002714) | 3.25194011 |
| 48 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.25194011 |
| 49 | folic acid metabolic process (GO:0046655) | 3.24393555 |
| 50 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 3.18400435 |
| 51 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.15767724 |
| 52 | positive regulation of fibroblast migration (GO:0010763) | 3.14742891 |
| 53 | regulation of immunoglobulin secretion (GO:0051023) | 3.13724734 |
| 54 | regulation of rhodopsin mediated signaling pathway (GO:0022400) | 3.12404673 |
| 55 | deoxyribonucleotide catabolic process (GO:0009264) | 3.09649965 |
| 56 | cell wall macromolecule catabolic process (GO:0016998) | 3.06040790 |
| 57 | intestinal cholesterol absorption (GO:0030299) | 3.03616425 |
| 58 | positive regulation of isotype switching (GO:0045830) | 3.03096874 |
| 59 | resolution of meiotic recombination intermediates (GO:0000712) | 2.96412758 |
| 60 | phosphatidylcholine acyl-chain remodeling (GO:0036151) | 2.95966454 |
| 61 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.94402456 |
| 62 | response to pheromone (GO:0019236) | 2.93629223 |
| 63 | negative regulation of acute inflammatory response (GO:0002674) | 2.91640471 |
| 64 | positive regulation of DNA recombination (GO:0045911) | 2.89968786 |
| 65 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 2.89537307 |
| 66 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 2.87065249 |
| 67 | positive regulation of mast cell degranulation (GO:0043306) | 2.85708915 |
| 68 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 2.85708915 |
| 69 | leukotriene biosynthetic process (GO:0019370) | 2.85656558 |
| 70 | cardiolipin metabolic process (GO:0032048) | 2.83842864 |
| 71 | deoxyribose phosphate catabolic process (GO:0046386) | 2.83268322 |
| 72 | signal peptide processing (GO:0006465) | 2.82067450 |
| 73 | methionine biosynthetic process (GO:0009086) | 2.82037594 |
| 74 | rhodopsin mediated signaling pathway (GO:0016056) | 2.82034693 |
| 75 | oogenesis (GO:0048477) | 2.79816674 |
| 76 | regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664) | 2.77841379 |
| 77 | S-adenosylmethionine metabolic process (GO:0046500) | 2.77641336 |
| 78 | regulation of glomerular filtration (GO:0003093) | 2.77484295 |
| 79 | pteridine-containing compound biosynthetic process (GO:0042559) | 2.77344974 |
| 80 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.74761225 |
| 81 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.74761225 |
| 82 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.74761225 |
| 83 | rRNA modification (GO:0000154) | 2.74469612 |
| 84 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.72412963 |
| 85 | kynurenine metabolic process (GO:0070189) | 2.72079501 |
| 86 | phosphatidylethanolamine acyl-chain remodeling (GO:0036152) | 2.71895634 |
| 87 | mast cell activation (GO:0045576) | 2.67346928 |
| 88 | behavioral response to nicotine (GO:0035095) | 2.66913495 |
| 89 | gamma-aminobutyric acid transport (GO:0015812) | 2.65129744 |
| 90 | multicellular organism reproduction (GO:0032504) | 2.64610001 |
| 91 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.63653622 |
| 92 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.63653622 |
| 93 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.63581528 |
| 94 | proteasome assembly (GO:0043248) | 2.63101746 |
| 95 | tryptophan catabolic process (GO:0006569) | 2.61571551 |
| 96 | indole-containing compound catabolic process (GO:0042436) | 2.61571551 |
| 97 | indolalkylamine catabolic process (GO:0046218) | 2.61571551 |
| 98 | negative regulation of macroautophagy (GO:0016242) | 2.60714519 |
| 99 | methionine metabolic process (GO:0006555) | 2.60448474 |
| 100 | negative regulation of heart contraction (GO:0045822) | 2.59472299 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 4.36256664 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.24831381 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.62250607 |
| 4 | VDR_22108803_ChIP-Seq_LS180_Human | 3.35287322 |
| 5 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.99476304 |
| 6 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.93118812 |
| 7 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.85743132 |
| 8 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.80729098 |
| 9 | EWS_26573619_Chip-Seq_HEK293_Human | 2.70546149 |
| 10 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.42953606 |
| 11 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.38353429 |
| 12 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.31079995 |
| 13 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.30707455 |
| 14 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.30655571 |
| 15 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.27769434 |
| 16 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 2.24000871 |
| 17 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.20802996 |
| 18 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.04605062 |
| 19 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.98541975 |
| 20 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.95257277 |
| 21 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.85284138 |
| 22 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.84997616 |
| 23 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.82983392 |
| 24 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.82381362 |
| 25 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.73188168 |
| 26 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.67236216 |
| 27 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.67102045 |
| 28 | FUS_26573619_Chip-Seq_HEK293_Human | 1.66811384 |
| 29 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.64778463 |
| 30 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.64485289 |
| 31 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.63919393 |
| 32 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.58440603 |
| 33 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.57497073 |
| 34 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.57497073 |
| 35 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.56376019 |
| 36 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.56376019 |
| 37 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.53151734 |
| 38 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.47412604 |
| 39 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.47364453 |
| 40 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.42627473 |
| 41 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.42561223 |
| 42 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.41098386 |
| 43 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.39823892 |
| 44 | GATA3_26560356_Chip-Seq_TH2_Human | 1.37677578 |
| 45 | AR_20517297_ChIP-Seq_VCAP_Human | 1.36644996 |
| 46 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.33865100 |
| 47 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.33690615 |
| 48 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.33690615 |
| 49 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.32274384 |
| 50 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.27215230 |
| 51 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.25299837 |
| 52 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.25079125 |
| 53 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.24526725 |
| 54 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.24423716 |
| 55 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.23925356 |
| 56 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 1.23791930 |
| 57 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.23196563 |
| 58 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.23053381 |
| 59 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.21898126 |
| 60 | P300_19829295_ChIP-Seq_ESCs_Human | 1.17712849 |
| 61 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.17667659 |
| 62 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.14939312 |
| 63 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.14036709 |
| 64 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.12848555 |
| 65 | NCOR_22424771_ChIP-Seq_293T_Human | 1.12784219 |
| 66 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.10676478 |
| 67 | SMAD1_18555785_Chip-Seq_ESCs_Mouse | 1.10359121 |
| 68 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.09504441 |
| 69 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.09452301 |
| 70 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 1.06036572 |
| 71 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 1.05975729 |
| 72 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.05899172 |
| 73 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.05298724 |
| 74 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.04816235 |
| 75 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.04484073 |
| 76 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.04170413 |
| 77 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.03804167 |
| 78 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 1.03467353 |
| 79 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.02530079 |
| 80 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.01848343 |
| 81 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 0.98622705 |
| 82 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.98533321 |
| 83 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 0.98080144 |
| 84 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.97284293 |
| 85 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.96901746 |
| 86 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.96198956 |
| 87 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.94652794 |
| 88 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.94055627 |
| 89 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.93840971 |
| 90 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.93611784 |
| 91 | GATA3_26560356_Chip-Seq_TH1_Human | 0.93512936 |
| 92 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.92958927 |
| 93 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.92827129 |
| 94 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.92382445 |
| 95 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.92173139 |
| 96 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.91445911 |
| 97 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.90974878 |
| 98 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.90948058 |
| 99 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.90062316 |
| 100 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.89123331 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003646_muscle_fatigue | 6.47733174 |
| 2 | MP0001835_abnormal_antigen_presentation | 3.71262621 |
| 3 | MP0004147_increased_porphyrin_level | 3.57056712 |
| 4 | MP0006072_abnormal_retinal_apoptosis | 3.05989209 |
| 5 | MP0002837_dystrophic_cardiac_calcinosis | 2.90601330 |
| 6 | MP0003195_calcinosis | 2.88711264 |
| 7 | MP0002166_altered_tumor_susceptibility | 2.72727753 |
| 8 | MP0003011_delayed_dark_adaptation | 2.55731018 |
| 9 | MP0010386_abnormal_urinary_bladder | 2.33972282 |
| 10 | MP0003786_premature_aging | 2.30615601 |
| 11 | MP0002148_abnormal_hypersensitivity_rea | 2.19205070 |
| 12 | MP0002006_tumorigenesis | 2.18132914 |
| 13 | MP0000516_abnormal_urinary_system | 2.14447999 |
| 14 | MP0005367_renal/urinary_system_phenotyp | 2.14447999 |
| 15 | MP0008875_abnormal_xenobiotic_pharmacok | 2.11082484 |
| 16 | MP0003718_maternal_effect | 2.03697040 |
| 17 | MP0001853_heart_inflammation | 1.99640160 |
| 18 | MP0009764_decreased_sensitivity_to | 1.97063944 |
| 19 | MP0008995_early_reproductive_senescence | 1.95293418 |
| 20 | MP0001790_abnormal_immune_system | 1.91446489 |
| 21 | MP0005387_immune_system_phenotype | 1.91446489 |
| 22 | MP0001666_abnormal_nutrient_absorption | 1.90923202 |
| 23 | MP0002876_abnormal_thyroid_physiology | 1.90826392 |
| 24 | MP0005671_abnormal_response_to | 1.83260138 |
| 25 | MP0006292_abnormal_olfactory_placode | 1.80630528 |
| 26 | MP0000465_gastrointestinal_hemorrhage | 1.68891277 |
| 27 | MP0002736_abnormal_nociception_after | 1.68751387 |
| 28 | MP0005551_abnormal_eye_electrophysiolog | 1.65334401 |
| 29 | MP0006036_abnormal_mitochondrial_physio | 1.64404304 |
| 30 | MP0005085_abnormal_gallbladder_physiolo | 1.61846827 |
| 31 | MP0005646_abnormal_pituitary_gland | 1.53587130 |
| 32 | MP0004142_abnormal_muscle_tone | 1.49327430 |
| 33 | MP0003638_abnormal_response/metabolism_ | 1.43316133 |
| 34 | MP0000685_abnormal_immune_system | 1.42943287 |
| 35 | MP0002277_abnormal_respiratory_mucosa | 1.41506761 |
| 36 | MP0005253_abnormal_eye_physiology | 1.38518834 |
| 37 | MP0001727_abnormal_embryo_implantation | 1.37760048 |
| 38 | MP0003806_abnormal_nucleotide_metabolis | 1.35765776 |
| 39 | MP0001800_abnormal_humoral_immune | 1.34432209 |
| 40 | MP0005365_abnormal_bile_salt | 1.30041316 |
| 41 | MP0008872_abnormal_physiological_respon | 1.29598189 |
| 42 | MP0003724_increased_susceptibility_to | 1.29372703 |
| 43 | MP0003136_yellow_coat_color | 1.29167848 |
| 44 | MP0000538_abnormal_urinary_bladder | 1.28490025 |
| 45 | MP0001968_abnormal_touch/_nociception | 1.24877377 |
| 46 | MP0001905_abnormal_dopamine_level | 1.24589461 |
| 47 | MP0005670_abnormal_white_adipose | 1.22556579 |
| 48 | MP0003878_abnormal_ear_physiology | 1.22119531 |
| 49 | MP0005377_hearing/vestibular/ear_phenot | 1.22119531 |
| 50 | MP0002160_abnormal_reproductive_system | 1.22050995 |
| 51 | MP0004043_abnormal_pH_regulation | 1.15686206 |
| 52 | MP0005389_reproductive_system_phenotype | 1.15328574 |
| 53 | MP0003567_abnormal_fetal_cardiomyocyte | 1.07967313 |
| 54 | MP0002139_abnormal_hepatobiliary_system | 1.05635397 |
| 55 | MP0005332_abnormal_amino_acid | 1.03027455 |
| 56 | MP0003300_gastrointestinal_ulcer | 1.01122815 |
| 57 | MP0005084_abnormal_gallbladder_morpholo | 1.00964003 |
| 58 | MP0002095_abnormal_skin_pigmentation | 0.97383217 |
| 59 | MP0002723_abnormal_immune_serum | 0.94691090 |
| 60 | MP0005397_hematopoietic_system_phenotyp | 0.94354150 |
| 61 | MP0001545_abnormal_hematopoietic_system | 0.94354150 |
| 62 | MP0000427_abnormal_hair_cycle | 0.93271667 |
| 63 | MP0003950_abnormal_plasma_membrane | 0.92673082 |
| 64 | MP0001764_abnormal_homeostasis | 0.92129146 |
| 65 | MP0009785_altered_susceptibility_to | 0.90274594 |
| 66 | MP0005000_abnormal_immune_tolerance | 0.88997163 |
| 67 | MP0001919_abnormal_reproductive_system | 0.88968707 |
| 68 | MP0005645_abnormal_hypothalamus_physiol | 0.86706726 |
| 69 | MP0010329_abnormal_lipoprotein_level | 0.86048876 |
| 70 | MP0008469_abnormal_protein_level | 0.85595334 |
| 71 | MP0002452_abnormal_antigen_presenting | 0.84464772 |
| 72 | MP0003075_altered_response_to | 0.84073356 |
| 73 | MP0001501_abnormal_sleep_pattern | 0.83697679 |
| 74 | MP0005647_abnormal_sex_gland | 0.82457161 |
| 75 | MP0005165_increased_susceptibility_to | 0.81230835 |
| 76 | MP0001485_abnormal_pinna_reflex | 0.81205801 |
| 77 | MP0005319_abnormal_enzyme/_coenzyme | 0.81148646 |
| 78 | MP0003763_abnormal_thymus_physiology | 0.80053664 |
| 79 | MP0004130_abnormal_muscle_cell | 0.79961186 |
| 80 | MP0002733_abnormal_thermal_nociception | 0.79253653 |
| 81 | MP0000604_amyloidosis | 0.77126160 |
| 82 | MP0001986_abnormal_taste_sensitivity | 0.76519002 |
| 83 | MP0003252_abnormal_bile_duct | 0.76281009 |
| 84 | MP0001293_anophthalmia | 0.75001591 |
| 85 | MP0002420_abnormal_adaptive_immunity | 0.74824329 |
| 86 | MP0000639_abnormal_adrenal_gland | 0.74284677 |
| 87 | MP0001819_abnormal_immune_cell | 0.73093162 |
| 88 | MP0005025_abnormal_response_to | 0.73045039 |
| 89 | MP0001845_abnormal_inflammatory_respons | 0.72996639 |
| 90 | MP0005636_abnormal_mineral_homeostasis | 0.72326195 |
| 91 | MP0005410_abnormal_fertilization | 0.72040790 |
| 92 | MP0009046_muscle_twitch | 0.71366230 |
| 93 | MP0002332_abnormal_exercise_endurance | 0.70371331 |
| 94 | MP0001529_abnormal_vocalization | 0.70169393 |
| 95 | MP0001970_abnormal_pain_threshold | 0.69201176 |
| 96 | MP0005535_abnormal_body_temperature | 0.69108618 |
| 97 | MP0003172_abnormal_lysosome_physiology | 0.69045599 |
| 98 | MP0004885_abnormal_endolymph | 0.67914027 |
| 99 | MP0000343_altered_response_to | 0.66815544 |
| 100 | MP0004019_abnormal_vitamin_homeostasis | 0.65848342 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of alanine metabolism (HP:0010916) | 7.76391305 |
| 2 | Hyperalaninemia (HP:0003348) | 7.76391305 |
| 3 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 7.76391305 |
| 4 | Congenital stationary night blindness (HP:0007642) | 6.94451950 |
| 5 | 3-Methylglutaconic aciduria (HP:0003535) | 6.82702675 |
| 6 | Congenital, generalized hypertrichosis (HP:0004540) | 5.15896841 |
| 7 | Agammaglobulinemia (HP:0004432) | 4.95706797 |
| 8 | Hyperglycinemia (HP:0002154) | 4.21393198 |
| 9 | Abnormality of serum amino acid levels (HP:0003112) | 4.15518193 |
| 10 | Methylmalonic acidemia (HP:0002912) | 4.04649190 |
| 11 | Acute necrotizing encephalopathy (HP:0006965) | 3.53457187 |
| 12 | Cutaneous melanoma (HP:0012056) | 3.49775039 |
| 13 | Prostate neoplasm (HP:0100787) | 3.28593313 |
| 14 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.23979768 |
| 15 | Mitochondrial inheritance (HP:0001427) | 3.18323858 |
| 16 | Hepatic necrosis (HP:0002605) | 3.17582586 |
| 17 | Progressive macrocephaly (HP:0004481) | 3.15472159 |
| 18 | Nausea (HP:0002018) | 3.15220703 |
| 19 | Increased CSF lactate (HP:0002490) | 3.12656984 |
| 20 | Methylmalonic aciduria (HP:0012120) | 3.08728642 |
| 21 | Hepatocellular necrosis (HP:0001404) | 3.07476014 |
| 22 | Acute encephalopathy (HP:0006846) | 2.94966397 |
| 23 | IgG deficiency (HP:0004315) | 2.93390315 |
| 24 | Chronic sinusitis (HP:0011109) | 2.89716382 |
| 25 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.88082816 |
| 26 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.88082816 |
| 27 | Microretrognathia (HP:0000308) | 2.83960370 |
| 28 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.80842249 |
| 29 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.78533095 |
| 30 | Increased serum lactate (HP:0002151) | 2.72947172 |
| 31 | Abnormality of vitamin B metabolism (HP:0004340) | 2.61416553 |
| 32 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.59580836 |
| 33 | Lactic acidosis (HP:0003128) | 2.53735356 |
| 34 | Type I transferrin isoform profile (HP:0003642) | 2.53649037 |
| 35 | Abnormality of midbrain morphology (HP:0002418) | 2.42520115 |
| 36 | Molar tooth sign on MRI (HP:0002419) | 2.42520115 |
| 37 | Recurrent bronchitis (HP:0002837) | 2.39937590 |
| 38 | Proximal tubulopathy (HP:0000114) | 2.38931384 |
| 39 | Spastic paraparesis (HP:0002313) | 2.38848631 |
| 40 | Persistence of primary teeth (HP:0006335) | 2.37283172 |
| 41 | Hypoplasia of the fovea (HP:0007750) | 2.34185980 |
| 42 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 2.34185980 |
| 43 | Supernumerary spleens (HP:0009799) | 2.32825961 |
| 44 | Testicular atrophy (HP:0000029) | 2.31015587 |
| 45 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.28601956 |
| 46 | Progressive external ophthalmoplegia (HP:0000590) | 2.28186259 |
| 47 | Abnormality of the proximal phalanges of the hand (HP:0009834) | 2.28092844 |
| 48 | Cellular immunodeficiency (HP:0005374) | 2.23099248 |
| 49 | Hyperammonemia (HP:0001987) | 2.19926021 |
| 50 | Dicarboxylic aciduria (HP:0003215) | 2.17287655 |
| 51 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.17287655 |
| 52 | Clumsiness (HP:0002312) | 2.15779060 |
| 53 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.15588182 |
| 54 | Delayed CNS myelination (HP:0002188) | 2.14589593 |
| 55 | Generalized aminoaciduria (HP:0002909) | 2.12743667 |
| 56 | Leukodystrophy (HP:0002415) | 2.11588083 |
| 57 | Sensorimotor neuropathy (HP:0007141) | 2.10110337 |
| 58 | Aplastic anemia (HP:0001915) | 2.09686799 |
| 59 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.07903740 |
| 60 | Nephronophthisis (HP:0000090) | 2.04110773 |
| 61 | Abolished electroretinogram (ERG) (HP:0000550) | 2.01255062 |
| 62 | Cerebral edema (HP:0002181) | 2.00635333 |
| 63 | Abnormality of the prostate (HP:0008775) | 1.94994163 |
| 64 | Abnormal spermatogenesis (HP:0008669) | 1.94915905 |
| 65 | Stomatitis (HP:0010280) | 1.94196971 |
| 66 | Exercise intolerance (HP:0003546) | 1.93987667 |
| 67 | Azoospermia (HP:0000027) | 1.92864201 |
| 68 | Lethargy (HP:0001254) | 1.92769557 |
| 69 | Respiratory failure (HP:0002878) | 1.90329166 |
| 70 | Progressive inability to walk (HP:0002505) | 1.90302108 |
| 71 | Reduced antithrombin III activity (HP:0001976) | 1.89111949 |
| 72 | Abnormality of glycine metabolism (HP:0010895) | 1.88651314 |
| 73 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.88651314 |
| 74 | Hydroureter (HP:0000072) | 1.87746503 |
| 75 | Increased serum ferritin (HP:0003281) | 1.87483849 |
| 76 | Optic disc pallor (HP:0000543) | 1.84930049 |
| 77 | Increased intramyocellular lipid droplets (HP:0012240) | 1.84154518 |
| 78 | Flat face (HP:0012368) | 1.83776559 |
| 79 | Vacuolated lymphocytes (HP:0001922) | 1.82647119 |
| 80 | Ketosis (HP:0001946) | 1.81811675 |
| 81 | Panhypogammaglobulinemia (HP:0003139) | 1.80078599 |
| 82 | Abnormality of vitamin metabolism (HP:0100508) | 1.79602832 |
| 83 | Abnormality of the middle phalanges of the toes (HP:0010183) | 1.79007846 |
| 84 | Glucose intolerance (HP:0000833) | 1.76843147 |
| 85 | Flared iliac wings (HP:0002869) | 1.76284961 |
| 86 | Encephalitis (HP:0002383) | 1.74689134 |
| 87 | Increased hepatocellular lipid droplets (HP:0006565) | 1.74505548 |
| 88 | Pancreatic cysts (HP:0001737) | 1.73701515 |
| 89 | Recurrent cutaneous fungal infections (HP:0011370) | 1.73500155 |
| 90 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.73500155 |
| 91 | Lipid accumulation in hepatocytes (HP:0006561) | 1.70600637 |
| 92 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.70265967 |
| 93 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.70265967 |
| 94 | Abnormal protein glycosylation (HP:0012346) | 1.70265967 |
| 95 | Abnormal glycosylation (HP:0012345) | 1.70265967 |
| 96 | Abnormality of iron homeostasis (HP:0011031) | 1.67267696 |
| 97 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.67236422 |
| 98 | Papilloma (HP:0012740) | 1.66614042 |
| 99 | Verrucae (HP:0200043) | 1.66614042 |
| 100 | Abnormal glucose tolerance (HP:0001952) | 1.65655010 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TESK2 | 9.39020746 |
| 2 | GRK1 | 4.84918255 |
| 3 | ZAK | 3.38950572 |
| 4 | TIE1 | 3.08064110 |
| 5 | EIF2AK1 | 2.77915763 |
| 6 | FRK | 2.72816728 |
| 7 | TAF1 | 2.59390828 |
| 8 | MAPKAPK5 | 2.55448789 |
| 9 | MKNK1 | 2.51526599 |
| 10 | CDC7 | 2.38165700 |
| 11 | NME1 | 2.01371064 |
| 12 | TXK | 1.99852869 |
| 13 | PDK2 | 1.68752332 |
| 14 | TLK1 | 1.67943840 |
| 15 | MAP3K13 | 1.67793028 |
| 16 | SIK3 | 1.50275174 |
| 17 | VRK2 | 1.45251631 |
| 18 | NUAK1 | 1.39840636 |
| 19 | TEC | 1.30840820 |
| 20 | TRPM7 | 1.29174191 |
| 21 | EIF2AK3 | 1.23656825 |
| 22 | MAPKAPK3 | 1.23354219 |
| 23 | MAP3K14 | 1.19241483 |
| 24 | KIT | 1.16023631 |
| 25 | LYN | 1.15904301 |
| 26 | WNK4 | 1.13407813 |
| 27 | NME2 | 1.08013708 |
| 28 | MST4 | 0.97983097 |
| 29 | ACVR1B | 0.96404245 |
| 30 | MAP4K1 | 0.94580670 |
| 31 | ITK | 0.86249497 |
| 32 | DAPK1 | 0.85852654 |
| 33 | VRK1 | 0.84086807 |
| 34 | RPS6KA5 | 0.82503761 |
| 35 | TYK2 | 0.81891528 |
| 36 | SYK | 0.77502391 |
| 37 | TSSK6 | 0.77412817 |
| 38 | STK16 | 0.75393061 |
| 39 | ADRBK2 | 0.74752029 |
| 40 | TNK2 | 0.73479128 |
| 41 | SMG1 | 0.71099363 |
| 42 | PLK3 | 0.69250009 |
| 43 | IRAK4 | 0.66071907 |
| 44 | MAP3K12 | 0.65380936 |
| 45 | EGFR | 0.63218878 |
| 46 | MYLK | 0.62120600 |
| 47 | OXSR1 | 0.61903275 |
| 48 | PLK4 | 0.58397492 |
| 49 | STK39 | 0.58018976 |
| 50 | PRKAA2 | 0.55436426 |
| 51 | LCK | 0.55046124 |
| 52 | HCK | 0.53386352 |
| 53 | MAP4K2 | 0.53090330 |
| 54 | INSRR | 0.52852055 |
| 55 | CSK | 0.52593144 |
| 56 | ERBB3 | 0.52544139 |
| 57 | BCKDK | 0.50721763 |
| 58 | IKBKB | 0.50473938 |
| 59 | BMPR2 | 0.48376743 |
| 60 | AKT2 | 0.47600448 |
| 61 | CHEK2 | 0.44289854 |
| 62 | CAMKK2 | 0.43681836 |
| 63 | PAK3 | 0.42893835 |
| 64 | MUSK | 0.42464610 |
| 65 | PRKCE | 0.41983514 |
| 66 | FLT3 | 0.40152024 |
| 67 | AURKB | 0.39214112 |
| 68 | EIF2AK2 | 0.39055284 |
| 69 | MAPK11 | 0.37150088 |
| 70 | FGFR2 | 0.37111658 |
| 71 | IGF1R | 0.37078227 |
| 72 | CSNK1G3 | 0.36175348 |
| 73 | CSNK2A2 | 0.36040866 |
| 74 | MAPK4 | 0.35460462 |
| 75 | ATR | 0.35299593 |
| 76 | CSNK2A1 | 0.34507446 |
| 77 | PRKACB | 0.33940217 |
| 78 | CAMK2A | 0.33001317 |
| 79 | RPS6KA4 | 0.32855489 |
| 80 | PRKACG | 0.32606552 |
| 81 | CSNK1G2 | 0.32252886 |
| 82 | RPS6KB2 | 0.30732182 |
| 83 | PLK1 | 0.29143744 |
| 84 | CAMK2B | 0.27763488 |
| 85 | KDR | 0.26937932 |
| 86 | DAPK3 | 0.26904769 |
| 87 | CSNK1A1L | 0.26904412 |
| 88 | PRKACA | 0.25821600 |
| 89 | DYRK2 | 0.25085608 |
| 90 | CDK7 | 0.24134544 |
| 91 | MAP2K6 | 0.23901417 |
| 92 | CAMK2G | 0.23737277 |
| 93 | CSNK1A1 | 0.22820087 |
| 94 | BUB1 | 0.22691844 |
| 95 | OBSCN | 0.21654542 |
| 96 | SIK2 | 0.21140635 |
| 97 | CSNK1G1 | 0.21131507 |
| 98 | INSR | 0.20740309 |
| 99 | CAMK2D | 0.20576859 |
| 100 | PAK4 | 0.20355054 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.10732502 |
| 2 | Protein export_Homo sapiens_hsa03060 | 3.71285927 |
| 3 | Asthma_Homo sapiens_hsa05310 | 3.63903370 |
| 4 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.26117409 |
| 5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.92254145 |
| 6 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.84180532 |
| 7 | Phototransduction_Homo sapiens_hsa04744 | 2.65876224 |
| 8 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.49873917 |
| 9 | Parkinsons disease_Homo sapiens_hsa05012 | 2.44165982 |
| 10 | Allograft rejection_Homo sapiens_hsa05330 | 2.35742546 |
| 11 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.27284588 |
| 12 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 2.21611164 |
| 13 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.14214231 |
| 14 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.04272595 |
| 15 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.86285796 |
| 16 | Ribosome_Homo sapiens_hsa03010 | 1.81263731 |
| 17 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.63434543 |
| 18 | Homologous recombination_Homo sapiens_hsa03440 | 1.60817415 |
| 19 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.60402642 |
| 20 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.58772139 |
| 21 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.57434237 |
| 22 | Huntingtons disease_Homo sapiens_hsa05016 | 1.55363269 |
| 23 | Alzheimers disease_Homo sapiens_hsa05010 | 1.50916006 |
| 24 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.48121176 |
| 25 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.44014752 |
| 26 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.40165969 |
| 27 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.39060945 |
| 28 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.38482865 |
| 29 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.37614009 |
| 30 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.37317595 |
| 31 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.30511303 |
| 32 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.25465858 |
| 33 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.10534010 |
| 34 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.10324216 |
| 35 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.07897510 |
| 36 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.02247679 |
| 37 | Retinol metabolism_Homo sapiens_hsa00830 | 0.98694107 |
| 38 | RNA degradation_Homo sapiens_hsa03018 | 0.98476438 |
| 39 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.96565755 |
| 40 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.95162288 |
| 41 | RNA polymerase_Homo sapiens_hsa03020 | 0.93185969 |
| 42 | Purine metabolism_Homo sapiens_hsa00230 | 0.93118493 |
| 43 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.89706367 |
| 44 | Mismatch repair_Homo sapiens_hsa03430 | 0.89528401 |
| 45 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.89366902 |
| 46 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.89341982 |
| 47 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.89129983 |
| 48 | Basal transcription factors_Homo sapiens_hsa03022 | 0.87661671 |
| 49 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.86310207 |
| 50 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.85296816 |
| 51 | Base excision repair_Homo sapiens_hsa03410 | 0.85056235 |
| 52 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.85048465 |
| 53 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.83029219 |
| 54 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.81152704 |
| 55 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.79921798 |
| 56 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.78766278 |
| 57 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.78584167 |
| 58 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.77374768 |
| 59 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.74103169 |
| 60 | Spliceosome_Homo sapiens_hsa03040 | 0.73750246 |
| 61 | DNA replication_Homo sapiens_hsa03030 | 0.72499627 |
| 62 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.72138065 |
| 63 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.68556099 |
| 64 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.65759441 |
| 65 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.65053933 |
| 66 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.62914814 |
| 67 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.59466036 |
| 68 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.59116946 |
| 69 | Metabolic pathways_Homo sapiens_hsa01100 | 0.56009100 |
| 70 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.55285148 |
| 71 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.53301359 |
| 72 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.52541889 |
| 73 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.49971619 |
| 74 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.49291219 |
| 75 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.48872590 |
| 76 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.48865706 |
| 77 | Nicotine addiction_Homo sapiens_hsa05033 | 0.47317735 |
| 78 | Peroxisome_Homo sapiens_hsa04146 | 0.46854788 |
| 79 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.46051969 |
| 80 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.45948742 |
| 81 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.44011137 |
| 82 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.43096625 |
| 83 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.42898477 |
| 84 | Leishmaniasis_Homo sapiens_hsa05140 | 0.42705502 |
| 85 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.42440840 |
| 86 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.42345379 |
| 87 | Olfactory transduction_Homo sapiens_hsa04740 | 0.40898498 |
| 88 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.40587025 |
| 89 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.39628397 |
| 90 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.38664588 |
| 91 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.37848666 |
| 92 | Histidine metabolism_Homo sapiens_hsa00340 | 0.35405118 |
| 93 | Sulfur relay system_Homo sapiens_hsa04122 | 0.33394713 |
| 94 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.31032561 |
| 95 | Other glycan degradation_Homo sapiens_hsa00511 | 0.30855670 |
| 96 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.30030016 |
| 97 | RNA transport_Homo sapiens_hsa03013 | 0.29896555 |
| 98 | Morphine addiction_Homo sapiens_hsa05032 | 0.29834620 |
| 99 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.25451021 |
| 100 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.22791954 |

