PHBP9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.94307854
2negative regulation of erythrocyte differentiation (GO:0045647)5.21407705
3response to muramyl dipeptide (GO:0032495)4.98003072
4regulation of gamma-delta T cell differentiation (GO:0045586)4.79533379
5positive regulation of granulocyte differentiation (GO:0030854)4.77125973
6regulation of gamma-delta T cell activation (GO:0046643)4.62536414
7negative thymic T cell selection (GO:0045060)4.42938003
8negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.41913747
9tolerance induction (GO:0002507)4.39016896
10positive regulation of B cell differentiation (GO:0045579)4.35045125
11response to peptidoglycan (GO:0032494)4.26736707
12negative T cell selection (GO:0043383)4.25328015
13histone H3-K36 demethylation (GO:0070544)4.19225071
14cellular extravasation (GO:0045123)4.12342116
15Peyers patch development (GO:0048541)4.09878062
16mucosal-associated lymphoid tissue development (GO:0048537)4.09878062
17positive thymic T cell selection (GO:0045059)3.81077375
18positive T cell selection (GO:0043368)3.79522905
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.75078365
20dosage compensation (GO:0007549)3.74257714
21regulation of B cell receptor signaling pathway (GO:0050855)3.72881001
22regulation of histone H3-K27 methylation (GO:0061085)3.72771390
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.71367457
24negative regulation of T cell mediated immunity (GO:0002710)3.70858316
253-UTR-mediated mRNA stabilization (GO:0070935)3.68703123
26T cell selection (GO:0045058)3.67149563
27thymic T cell selection (GO:0045061)3.65586871
28B cell receptor signaling pathway (GO:0050853)3.61205602
29regulation of B cell differentiation (GO:0045577)3.57529353
30leukocyte aggregation (GO:0070486)3.48640475
31histone H3-K4 trimethylation (GO:0080182)3.43312648
32negative regulation of cell killing (GO:0031342)3.40938492
33negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.40938492
34negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.38092594
35T cell migration (GO:0072678)3.34738282
36regulation of granulocyte differentiation (GO:0030852)3.33368990
37definitive hemopoiesis (GO:0060216)3.25843772
38negative regulation of interleukin-12 production (GO:0032695)3.22002548
39histone lysine demethylation (GO:0070076)3.20016408
40histone demethylation (GO:0016577)3.18834732
41negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.17980088
42activated T cell proliferation (GO:0050798)3.15938856
43B cell homeostasis (GO:0001782)3.12886319
44histone H3-K4 methylation (GO:0051568)3.10542718
45histone H3-K9 demethylation (GO:0033169)3.08623497
46modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.07448475
47positive regulation by organism of defense response of other organism involved in symbiotic interact3.07448475
48modulation by symbiont of host immune response (GO:0052553)3.07448475
49positive regulation by symbiont of host defense response (GO:0052509)3.07448475
50modulation by symbiont of host defense response (GO:0052031)3.07448475
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.07448475
52germinal center formation (GO:0002467)3.04532720
53embryonic process involved in female pregnancy (GO:0060136)3.02736281
54negative regulation of histone methylation (GO:0031061)3.00984197
55mRNA splice site selection (GO:0006376)3.00953887
56NIK/NF-kappaB signaling (GO:0038061)3.00180043
57T cell homeostasis (GO:0043029)2.98442372
58regulation of erythrocyte differentiation (GO:0045646)2.92578611
59negative regulation of lymphocyte mediated immunity (GO:0002707)2.92024310
60natural killer cell differentiation (GO:0001779)2.91241904
61positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.89618568
62antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.89519537
63antigen processing and presentation of endogenous antigen (GO:0019883)2.89402734
64regulation of necroptotic process (GO:0060544)2.88458759
65negative regulation of RNA splicing (GO:0033119)2.86944629
66regulation of alpha-beta T cell proliferation (GO:0046640)2.84860393
67histone H3-K9 modification (GO:0061647)2.83831901
68mannose metabolic process (GO:0006013)2.83252285
69protein demethylation (GO:0006482)2.83119924
70protein dealkylation (GO:0008214)2.83119924
71regulation of interleukin-2 biosynthetic process (GO:0045076)2.80248874
72granulocyte differentiation (GO:0030851)2.80213640
73mature B cell differentiation involved in immune response (GO:0002313)2.79922830
74antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.77014013
75energy homeostasis (GO:0097009)2.76297943
76response to host immune response (GO:0052572)2.75913898
77response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.75913898
78defense response to protozoan (GO:0042832)2.72776781
79lymphocyte homeostasis (GO:0002260)2.70365308
80histone H3 deacetylation (GO:0070932)2.69316018
81negative regulation of mRNA processing (GO:0050686)2.69106330
82positive regulation of Rap GTPase activity (GO:0032854)2.68581855
83response to host (GO:0075136)2.67804106
84response to host defenses (GO:0052200)2.67804106
85response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.67804106
86phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.66480308
87alpha-beta T cell activation (GO:0046631)2.63654478
88positive regulation of alpha-beta T cell proliferation (GO:0046641)2.62248493
89response to protozoan (GO:0001562)2.60076997
90leukocyte homeostasis (GO:0001776)2.59805923
91negative regulation of interleukin-6 production (GO:0032715)2.59374210
92interferon-gamma production (GO:0032609)2.57620317
93detection of other organism (GO:0098543)2.57444543
94alpha-beta T cell differentiation (GO:0046632)2.56888044
95response to interleukin-15 (GO:0070672)2.56584284
96peptidyl-lysine trimethylation (GO:0018023)2.56103325
97V(D)J recombination (GO:0033151)2.55863372
98mature B cell differentiation (GO:0002335)2.54220429
99CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.52183770
100negative regulation of leukocyte mediated immunity (GO:0002704)2.51897958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human4.17463890
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.95569532
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.86868227
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.65293334
5VDR_21846776_ChIP-Seq_THP-1_Human3.24199560
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.03787807
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.01115345
8E2F7_22180533_ChIP-Seq_HELA_Human2.89702368
9MAF_26560356_Chip-Seq_TH1_Human2.76278661
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.73895870
11MYB_26560356_Chip-Seq_TH2_Human2.61471847
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.61114070
13RUNX_20019798_ChIP-Seq_JUKART_Human2.47322419
14TCF7_22412390_ChIP-Seq_EML_Mouse2.47169196
15KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.43148893
16VDR_24763502_ChIP-Seq_THP-1_Human2.41895772
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.41744875
18UTX_26944678_Chip-Seq_JUKART_Human2.40063153
19SCL_19346495_ChIP-Seq_HPC-7_Human2.39090527
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36934034
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.34835469
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33676693
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.30280372
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.29606465
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28856362
26CIITA_25753668_ChIP-Seq_RAJI_Human2.28289557
27MYB_26560356_Chip-Seq_TH1_Human2.26278271
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.17367377
29KDM2B_26808549_Chip-Seq_DND41_Human2.16553738
30MAF_26560356_Chip-Seq_TH2_Human2.16335753
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15233205
32KDM2B_26808549_Chip-Seq_SUP-B15_Human2.13374608
33SPI1_23547873_ChIP-Seq_NB4_Human2.11271022
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.05280358
35RUNX1_22412390_ChIP-Seq_EML_Mouse2.03103636
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01522875
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99981732
38SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.80653150
39GATA1_22025678_ChIP-Seq_K562_Human1.76631938
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.75963649
41TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.73001118
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70064906
43SPI1_23127762_ChIP-Seq_K562_Human1.69805614
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.68042313
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66289569
46KDM2B_26808549_Chip-Seq_JURKAT_Human1.65699590
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64465326
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.64049307
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57057682
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52049552
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.51702036
52GATA3_27048872_Chip-Seq_THYMUS_Human1.50801896
53NCOR1_26117541_ChIP-Seq_K562_Human1.49512968
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48941746
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46477982
56GATA1_19941827_ChIP-Seq_MEL_Mouse1.41371542
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35492236
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32475424
59PU_27001747_Chip-Seq_BMDM_Mouse1.28625646
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28307495
61GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.28306127
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.26195548
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20893043
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19095231
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18656482
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16737550
67VDR_24787735_ChIP-Seq_THP-1_Human1.16670316
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15299146
69RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13399193
70KDM5A_27292631_Chip-Seq_BREAST_Human1.13032560
71CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12480592
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12416713
73PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12320902
74TFEB_21752829_ChIP-Seq_HELA_Human1.11429209
75GATA1_19941826_ChIP-Seq_K562_Human1.07985265
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05605321
77EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04437672
78VDR_23849224_ChIP-Seq_CD4+_Human1.02117991
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02057624
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99657994
81LXR_22292898_ChIP-Seq_THP-1_Human0.97850973
82FOXP3_21729870_ChIP-Seq_TREG_Human0.95243032
83CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94889061
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94624898
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94053163
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93974481
87PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93404211
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92682081
89GATA3_26560356_Chip-Seq_TH2_Human0.92462727
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90150952
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90036790
92CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88435521
93FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86102593
94Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84184165
95FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83862733
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83434957
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83300024
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83060451
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.82919837
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.80444141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.20584248
2MP0003763_abnormal_thymus_physiology3.99765357
3MP0003436_decreased_susceptibility_to3.77717386
4MP0002396_abnormal_hematopoietic_system3.14365582
5MP0008260_abnormal_autophagy2.89083152
6MP0001800_abnormal_humoral_immune2.56577848
7MP0009278_abnormal_bone_marrow2.56513996
8MP0001835_abnormal_antigen_presentation2.56233380
9MP0000685_abnormal_immune_system2.41573161
10MP0002009_preneoplasia2.38861031
11MP0005000_abnormal_immune_tolerance2.33612995
12MP0002398_abnormal_bone_marrow2.28337105
13MP0002420_abnormal_adaptive_immunity2.25161105
14MP0003303_peritoneal_inflammation2.22622382
15MP0003300_gastrointestinal_ulcer2.22189843
16MP0001819_abnormal_immune_cell2.22101134
17MP0002723_abnormal_immune_serum2.12711344
18MP0005397_hematopoietic_system_phenotyp2.12586208
19MP0001545_abnormal_hematopoietic_system2.12586208
20MP0002452_abnormal_antigen_presenting2.12447027
21MP0005387_immune_system_phenotype2.11886378
22MP0001790_abnormal_immune_system2.11886378
23MP0000703_abnormal_thymus_morphology2.10472853
24MP0002419_abnormal_innate_immunity2.05449341
25MP0001853_heart_inflammation1.99116397
26MP0004808_abnormal_hematopoietic_stem1.96805526
27MP0005025_abnormal_response_to1.95441432
28MP0000716_abnormal_immune_system1.91807023
29MP0009333_abnormal_splenocyte_physiolog1.90427462
30MP0002722_abnormal_immune_system1.89705657
31MP0000689_abnormal_spleen_morphology1.89344315
32MP0003656_abnormal_erythrocyte_physiolo1.84310735
33MP0005076_abnormal_cell_differentiation1.82156616
34MP0002405_respiratory_system_inflammati1.80745138
35MP0003172_abnormal_lysosome_physiology1.80193074
36MP0005464_abnormal_platelet_physiology1.74729602
37MP0004510_myositis1.74399474
38MP0002429_abnormal_blood_cell1.65533368
39MP0005671_abnormal_response_to1.58888475
40MP0003724_increased_susceptibility_to1.56143306
41MP0004947_skin_inflammation1.54065706
42MP0001873_stomach_inflammation1.51587301
43MP0008961_abnormal_basal_metabolism1.50460654
44MP0005451_abnormal_body_composition1.49125776
45MP0005058_abnormal_lysosome_morphology1.48334505
46MP0005310_abnormal_salivary_gland1.47963584
47MP0002166_altered_tumor_susceptibility1.44543147
48MP0001851_eye_inflammation1.38635790
49MP0003828_pulmonary_edema1.34613694
50MP0004233_abnormal_muscle_weight1.33151906
51MP0003866_abnormal_defecation1.32359240
52MP0010155_abnormal_intestine_physiology1.30860835
53MP0001533_abnormal_skeleton_physiology1.28944205
54MP0000465_gastrointestinal_hemorrhage1.24889104
55MP0004381_abnormal_hair_follicle1.23248127
56MP0002933_joint_inflammation1.22679862
57MP0002132_abnormal_respiratory_system1.20147030
58MP0009785_altered_susceptibility_to1.19524891
59MP0001845_abnormal_inflammatory_respons1.18689424
60MP0003221_abnormal_cardiomyocyte_apopto1.13677561
61MP0002019_abnormal_tumor_incidence1.13498047
62MP0002148_abnormal_hypersensitivity_rea1.12491800
63MP0005075_abnormal_melanosome_morpholog1.11611257
64MP0005621_abnormal_cell_physiology1.10253717
65MP0002998_abnormal_bone_remodeling1.08183667
66MP0004185_abnormal_adipocyte_glucose1.07507359
67MP0002138_abnormal_hepatobiliary_system1.06061374
68MP0003111_abnormal_nucleus_morphology1.03404887
69MP0003077_abnormal_cell_cycle1.02637346
70MP0003786_premature_aging1.00908937
71MP0000490_abnormal_crypts_of0.92116325
72MP0002006_tumorigenesis0.92009781
73MP0000858_altered_metastatic_potential0.91476231
74MP0008469_abnormal_protein_level0.88292765
75MP0010094_abnormal_chromosome_stability0.85240968
76MP0005666_abnormal_adipose_tissue0.80601175
77MP0000350_abnormal_cell_proliferation0.80222495
78MP0008995_early_reproductive_senescence0.79116342
79MP0003091_abnormal_cell_migration0.78165351
80MP0008007_abnormal_cellular_replicative0.77369645
81MP0005384_cellular_phenotype0.77323957
82MP0009115_abnormal_fat_cell0.76565411
83MP0002970_abnormal_white_adipose0.76192716
84MP0006082_CNS_inflammation0.74636597
85MP0000313_abnormal_cell_death0.73592448
86MP0009763_increased_sensitivity_to0.72056860
87MP0003448_altered_tumor_morphology0.71758283
88MP0002822_catalepsy0.70722123
89MP0003045_fibrosis0.69783136
90MP0003183_abnormal_peptide_metabolism0.69671909
91MP0003943_abnormal_hepatobiliary_system0.69229102
92MP0005266_abnormal_metabolism0.68808343
93MP0004130_abnormal_muscle_cell0.68628613
94MP0008058_abnormal_DNA_repair0.67374085
95MP0001502_abnormal_circadian_rhythm0.66818941
96MP0009764_decreased_sensitivity_to0.66601603
97MP0001348_abnormal_lacrimal_gland0.64079341
98MP0005375_adipose_tissue_phenotype0.63802662
99MP0003453_abnormal_keratinocyte_physiol0.63251737
100MP0005334_abnormal_fat_pad0.62586297

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.77022855
2Panhypogammaglobulinemia (HP:0003139)4.43549251
3Recurrent fungal infections (HP:0002841)4.33697640
4Abnormal delayed hypersensitivity skin test (HP:0002963)4.19555214
5Chronic mucocutaneous candidiasis (HP:0002728)4.09134917
6Recurrent cutaneous fungal infections (HP:0011370)4.09134917
7Recurrent viral infections (HP:0004429)3.85435847
8Pustule (HP:0200039)3.74095350
9Colitis (HP:0002583)3.73517696
10Recurrent bacterial skin infections (HP:0005406)3.69228437
11Papilledema (HP:0001085)3.59017431
12Abnormality of the fingertips (HP:0001211)3.51305102
13Recurrent abscess formation (HP:0002722)3.29024979
14Increased IgE level (HP:0003212)3.28979510
15Mediastinal lymphadenopathy (HP:0100721)3.25466887
16Gastrointestinal inflammation (HP:0004386)3.23922196
17Prolonged bleeding time (HP:0003010)3.19676372
18Elevated erythrocyte sedimentation rate (HP:0003565)3.15994469
19Viral hepatitis (HP:0006562)3.15333546
20Agammaglobulinemia (HP:0004432)3.03049939
21Recurrent skin infections (HP:0001581)3.00760414
22Cellulitis (HP:0100658)3.00496824
23Slow saccadic eye movements (HP:0000514)2.98806737
24Inflammation of the large intestine (HP:0002037)2.98615355
25Myositis (HP:0100614)2.98277372
26Meningitis (HP:0001287)2.94793466
27Stomatitis (HP:0010280)2.86215358
28Basal cell carcinoma (HP:0002671)2.76560185
29Annular pancreas (HP:0001734)2.70840010
30Abnormality of macrophages (HP:0004311)2.70064957
31Abnormality of T cell physiology (HP:0011840)2.68410494
32Fatigue (HP:0012378)2.67329616
33T lymphocytopenia (HP:0005403)2.64892119
34Prominent nose (HP:0000448)2.64775879
35Acute myeloid leukemia (HP:0004808)2.64598856
36Abnormality of T cells (HP:0002843)2.62848114
37Granulocytopenia (HP:0001913)2.56000618
38Verrucae (HP:0200043)2.54813991
39Papilloma (HP:0012740)2.54813991
40Recurrent gram-negative bacterial infections (HP:0005420)2.53685224
41Autoimmune hemolytic anemia (HP:0001890)2.49755244
42Epistaxis (HP:0000421)2.49604310
43Broad face (HP:0000283)2.48794065
44Encephalitis (HP:0002383)2.45562568
45Dislocated radial head (HP:0003083)2.45149936
46Severe combined immunodeficiency (HP:0004430)2.36244489
47Abnormality of T cell number (HP:0011839)2.35580905
48Narrow palate (HP:0000189)2.31662190
49Long eyelashes (HP:0000527)2.31331501
50Orchitis (HP:0100796)2.30163045
51Retrobulbar optic neuritis (HP:0100654)2.28673036
52Optic neuritis (HP:0100653)2.28673036
53Vasculitis (HP:0002633)2.27515089
54Chronic obstructive pulmonary disease (HP:0006510)2.25478677
55Obstructive lung disease (HP:0006536)2.25478677
56Spontaneous hematomas (HP:0007420)2.23868542
57Abnormality of the radial head (HP:0003995)2.21821624
58Abnormality of the columella (HP:0009929)2.20938237
59Lymphopenia (HP:0001888)2.18988168
60Acute lymphatic leukemia (HP:0006721)2.17053547
61Premature skin wrinkling (HP:0100678)2.16455303
62Subacute progressive viral hepatitis (HP:0006572)2.13499730
63Osteomyelitis (HP:0002754)2.12592419
64Anhidrosis (HP:0000970)2.10590755
65Personality changes (HP:0000751)2.09786022
66Dysmetric saccades (HP:0000641)2.01540278
67Gastrointestinal infarctions (HP:0005244)2.01210962
68Seborrheic dermatitis (HP:0001051)1.99032475
69Abnormality of cells of the lymphoid lineage (HP:0012140)1.98473534
70IgM deficiency (HP:0002850)1.98079880
71Stomach cancer (HP:0012126)1.97561839
72Hepatitis (HP:0012115)1.97118516
73Increased serum ferritin (HP:0003281)1.94269523
74Cutis marmorata (HP:0000965)1.93779886
75Abnormal hair whorl (HP:0010721)1.93737904
76Deep palmar crease (HP:0006191)1.93303846
77Obstructive sleep apnea (HP:0002870)1.92932499
78Sandal gap (HP:0001852)1.90840956
79Centrally nucleated skeletal muscle fibers (HP:0003687)1.90676216
80Leukocytosis (HP:0001974)1.89946978
81Autoimmune thrombocytopenia (HP:0001973)1.89403392
82Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.89361710
83Combined immunodeficiency (HP:0005387)1.89272447
84Aplasia/Hypoplasia of the thymus (HP:0010515)1.88532744
85Broad palm (HP:0001169)1.83156334
86Chest pain (HP:0100749)1.79376398
87Teleangiectasia of the skin (HP:0100585)1.79089563
88Gingivitis (HP:0000230)1.78862864
89Heterotopia (HP:0002282)1.75948655
90Episodic fever (HP:0001954)1.74704440
91Keratoconjunctivitis (HP:0001096)1.74032643
92Abnormality of the thoracic spine (HP:0100711)1.73683485
93Urticaria (HP:0001025)1.73358355
94Gastrointestinal stroma tumor (HP:0100723)1.72987128
95Supernumerary ribs (HP:0005815)1.71363710
96Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.70437165
97Thoracic kyphosis (HP:0002942)1.70081159
98Genetic anticipation (HP:0003743)1.68962608
99Reticulocytosis (HP:0001923)1.68923109
100Abnormality of the peritoneum (HP:0002585)1.68738192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.66968247
2CDK123.48765099
3MAP4K13.34821079
4MAP2K32.88761116
5TYK22.26227875
6RIPK42.11605981
7EEF2K1.91965401
8BRD41.90338271
9BTK1.88864698
10IRAK41.87812979
11ERN11.84118522
12TRIB31.79960606
13ZAP701.74660751
14SIK31.74531793
15PASK1.71081165
16MAP3K101.70663478
17GRK61.66724330
18FES1.66656797
19MAP3K141.61637349
20JAK31.58863701
21SCYL21.58859464
22TXK1.55166623
23IKBKE1.54131560
24BLK1.49376128
25NLK1.47787452
26MARK21.38485816
27TAOK21.37479111
28IRAK11.35490290
29TBK11.33913526
30TNK21.31039494
31TEC1.30768710
32IRAK21.30514013
33ITK1.30078072
34SIK11.25623391
35HCK1.23256673
36SIK21.19015111
37SYK1.18756894
38EPHB11.17635980
39ICK1.16711243
40FGFR41.12015016
41MAPK111.10238221
42JAK11.08813935
43CAMKK11.07288063
44TAOK11.06529057
45MAP3K11.05846379
46HIPK21.03806291
47CSK0.99173791
48IKBKB0.97546743
49FGFR30.96551703
50MAPK120.93517535
51CDK40.92762462
52MAP3K130.92515842
53LCK0.91952699
54MARK30.91509351
55CAMKK20.89042606
56MAP3K70.88796905
57TRPM70.86951627
58CDK60.83870394
59TAOK30.83381674
60MATK0.82021358
61CHUK0.81041072
62JAK20.79336668
63MAP3K110.76121815
64CDC42BPA0.75628176
65MAP3K30.73497683
66LYN0.72678487
67MAP3K60.72158289
68RPS6KL10.72109495
69RPS6KC10.72109495
70MTOR0.72025554
71CSF1R0.69295602
72MAPKAPK30.68846671
73CAMK1D0.68611875
74RPS6KB20.67652564
75KIT0.67078433
76TTN0.66843893
77NEK90.65288634
78STK100.63882937
79PIM10.61835452
80MAPK70.59418030
81RPS6KA60.57211186
82CAMK40.56701014
83PIK3CG0.55016248
84RET0.52750107
85PIK3CA0.50893897
86DYRK1B0.49611854
87MKNK10.48328653
88MAPK30.47463004
89SGK30.46931390
90TESK20.46758470
91KSR20.45908791
92SGK20.44791995
93BMPR20.44636868
94ATR0.44466611
95PDK10.44278167
96MAPK80.42828602
97MAPK100.42057524
98MKNK20.40464612
99YES10.38473260
100MAP2K60.37943235

Predicted pathways (KEGG)

RankGene SetZ-score
1Acute myeloid leukemia_Homo sapiens_hsa052212.60801829
2B cell receptor signaling pathway_Homo sapiens_hsa046622.57638284
3Primary immunodeficiency_Homo sapiens_hsa053402.42558129
4T cell receptor signaling pathway_Homo sapiens_hsa046602.28535425
5Osteoclast differentiation_Homo sapiens_hsa043802.28104721
6Non-small cell lung cancer_Homo sapiens_hsa052231.94900885
7Leishmaniasis_Homo sapiens_hsa051401.91275391
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.90774700
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.86493595
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.85448824
11Measles_Homo sapiens_hsa051621.82374748
12Chronic myeloid leukemia_Homo sapiens_hsa052201.79172126
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66943944
14Other glycan degradation_Homo sapiens_hsa005111.66871605
15Herpes simplex infection_Homo sapiens_hsa051681.64657874
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63490557
17Hepatitis B_Homo sapiens_hsa051611.59968449
18Pancreatic cancer_Homo sapiens_hsa052121.58197395
19TNF signaling pathway_Homo sapiens_hsa046681.48897714
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48415148
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45909198
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.41390592
23VEGF signaling pathway_Homo sapiens_hsa043701.40178424
24Colorectal cancer_Homo sapiens_hsa052101.39296472
25Influenza A_Homo sapiens_hsa051641.38262348
26Renal cell carcinoma_Homo sapiens_hsa052111.36867452
27Circadian rhythm_Homo sapiens_hsa047101.34679462
28Tuberculosis_Homo sapiens_hsa051521.34552255
29Toxoplasmosis_Homo sapiens_hsa051451.34393048
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.29288097
31mTOR signaling pathway_Homo sapiens_hsa041501.27208106
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24450369
33Epstein-Barr virus infection_Homo sapiens_hsa051691.22454252
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21317665
35Viral carcinogenesis_Homo sapiens_hsa052031.20742192
36Hematopoietic cell lineage_Homo sapiens_hsa046401.18092149
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16935772
38Platelet activation_Homo sapiens_hsa046111.13226897
39Prolactin signaling pathway_Homo sapiens_hsa049171.13001445
40Endometrial cancer_Homo sapiens_hsa052131.12870349
41Shigellosis_Homo sapiens_hsa051311.12597577
42FoxO signaling pathway_Homo sapiens_hsa040681.11198014
43Inositol phosphate metabolism_Homo sapiens_hsa005621.10216477
44Apoptosis_Homo sapiens_hsa042101.10117178
45HTLV-I infection_Homo sapiens_hsa051661.10095524
46Allograft rejection_Homo sapiens_hsa053301.09531353
47Autoimmune thyroid disease_Homo sapiens_hsa053201.09151749
48Graft-versus-host disease_Homo sapiens_hsa053321.06455616
49Chemokine signaling pathway_Homo sapiens_hsa040621.05860874
50Spliceosome_Homo sapiens_hsa030401.03030897
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00260625
52Lysine degradation_Homo sapiens_hsa003100.99619443
53Choline metabolism in cancer_Homo sapiens_hsa052310.98686362
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96392578
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.95911752
56Insulin resistance_Homo sapiens_hsa049310.95337484
57Regulation of autophagy_Homo sapiens_hsa041400.94731657
58mRNA surveillance pathway_Homo sapiens_hsa030150.93923250
59Prostate cancer_Homo sapiens_hsa052150.93783069
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93560922
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93370428
62Non-homologous end-joining_Homo sapiens_hsa034500.90884175
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89643759
64Legionellosis_Homo sapiens_hsa051340.89579083
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.89142341
66Hepatitis C_Homo sapiens_hsa051600.86500651
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85855136
68Notch signaling pathway_Homo sapiens_hsa043300.84312382
69ErbB signaling pathway_Homo sapiens_hsa040120.84073475
70HIF-1 signaling pathway_Homo sapiens_hsa040660.82383643
71Base excision repair_Homo sapiens_hsa034100.81315374
72Thyroid cancer_Homo sapiens_hsa052160.77832906
73Viral myocarditis_Homo sapiens_hsa054160.76516471
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75020149
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.74401874
76Small cell lung cancer_Homo sapiens_hsa052220.73292653
77Malaria_Homo sapiens_hsa051440.73100423
78Type II diabetes mellitus_Homo sapiens_hsa049300.73067831
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.71663266
80Antigen processing and presentation_Homo sapiens_hsa046120.71256722
81MAPK signaling pathway_Homo sapiens_hsa040100.70834748
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69395705
83Cell cycle_Homo sapiens_hsa041100.68143842
84Type I diabetes mellitus_Homo sapiens_hsa049400.67887955
85Staphylococcus aureus infection_Homo sapiens_hsa051500.63381955
86DNA replication_Homo sapiens_hsa030300.63283291
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62145725
88MicroRNAs in cancer_Homo sapiens_hsa052060.62109105
89GnRH signaling pathway_Homo sapiens_hsa049120.60838742
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.60156322
91Glioma_Homo sapiens_hsa052140.59310955
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59269199
93Pertussis_Homo sapiens_hsa051330.59073159
94Insulin signaling pathway_Homo sapiens_hsa049100.57839566
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56154986
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52106031
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.50841115
98RNA transport_Homo sapiens_hsa030130.50362525
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.47648828
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44764708

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