PHC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)9.46330475
2polyketide metabolic process (GO:0030638)9.46330475
3doxorubicin metabolic process (GO:0044598)9.46330475
4protein localization to kinetochore (GO:0034501)6.15073896
5aminoglycoside antibiotic metabolic process (GO:0030647)6.14200353
6maintenance of protein location in nucleus (GO:0051457)6.12444661
7regulation of telomere maintenance via telomerase (GO:0032210)5.98080995
8somite rostral/caudal axis specification (GO:0032525)5.97253927
9regulation of nuclear cell cycle DNA replication (GO:0033262)5.81433052
10regulation of response to osmotic stress (GO:0047484)5.81085837
11establishment of integrated proviral latency (GO:0075713)5.79677257
12regulation of mammary gland epithelial cell proliferation (GO:0033599)5.79094245
13histone H4-K12 acetylation (GO:0043983)5.68563119
14negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.61781073
15negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.42657576
16histone H4-K5 acetylation (GO:0043981)5.41842461
17histone H4-K8 acetylation (GO:0043982)5.41842461
18negative regulation of telomerase activity (GO:0051974)5.41124725
19L-serine metabolic process (GO:0006563)5.40500080
20negative regulation of epidermis development (GO:0045683)5.36416739
21mitotic sister chromatid segregation (GO:0000070)5.15129377
22regulation of MHC class I biosynthetic process (GO:0045343)5.12492905
23negative regulation of cell cycle G2/M phase transition (GO:1902750)5.01577668
24heterochromatin organization (GO:0070828)4.93746039
25protein complex localization (GO:0031503)4.86192074
26notochord development (GO:0030903)4.84413170
27regulation of posttranscriptional gene silencing (GO:0060147)4.74553483
28regulation of gene silencing by miRNA (GO:0060964)4.74553483
29regulation of gene silencing by RNA (GO:0060966)4.74553483
30DNA replication-dependent nucleosome organization (GO:0034723)4.74442464
31DNA replication-dependent nucleosome assembly (GO:0006335)4.74442464
32muscle organ morphogenesis (GO:0048644)4.73478100
33nuclear pore complex assembly (GO:0051292)4.70207814
34rRNA transcription (GO:0009303)4.69871390
35protein localization to chromosome, centromeric region (GO:0071459)4.63449604
36IMP biosynthetic process (GO:0006188)4.59807174
37pre-miRNA processing (GO:0031054)4.56661061
38negative regulation of translation, ncRNA-mediated (GO:0040033)4.52551072
39regulation of translation, ncRNA-mediated (GO:0045974)4.52551072
40negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.52551072
41positive regulation of SMAD protein import into nucleus (GO:0060391)4.44955598
42regulation of cilium movement (GO:0003352)4.41358426
43regulation of histone H3-K9 methylation (GO:0051570)4.39105436
44sister chromatid segregation (GO:0000819)4.38046546
45positive regulation of DNA-dependent DNA replication (GO:2000105)4.37293004
46nuclear pore organization (GO:0006999)4.35027336
47paraxial mesoderm development (GO:0048339)4.32656755
48chromatin assembly (GO:0031497)4.31395274
49IMP metabolic process (GO:0046040)4.27964995
50establishment of viral latency (GO:0019043)4.27154717
51cell fate commitment involved in formation of primary germ layer (GO:0060795)4.25598618
52negative regulation of epidermal cell differentiation (GO:0045605)4.16613813
53negative regulation of telomere maintenance (GO:0032205)4.14742879
54regulation of helicase activity (GO:0051095)4.11298696
55histone H4-K16 acetylation (GO:0043984)4.06091621
56regulation of cell fate specification (GO:0042659)4.05431415
57branching involved in mammary gland duct morphogenesis (GO:0060444)3.95481913
58DNA replication checkpoint (GO:0000076)3.95081270
59negative regulation of histone methylation (GO:0031061)3.94114915
60primitive streak formation (GO:0090009)3.93896037
61L-alpha-amino acid transmembrane transport (GO:1902475)3.92390938
62rRNA methylation (GO:0031167)3.86510302
63cytidine metabolic process (GO:0046087)3.85920894
64cytidine catabolic process (GO:0006216)3.85920894
65cytidine deamination (GO:0009972)3.85920894
66nucleoside transmembrane transport (GO:1901642)3.83520099
67regulation of translation in response to stress (GO:0043555)3.82150069
68response to dietary excess (GO:0002021)3.82126710
69DNA strand elongation involved in DNA replication (GO:0006271)3.80475294
70chromatin remodeling at centromere (GO:0031055)3.76460059
71negative regulation of mitotic sister chromatid separation (GO:2000816)3.75764075
72negative regulation of sister chromatid segregation (GO:0033046)3.75764075
73negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.75764075
74negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.75764075
75negative regulation of mitotic sister chromatid segregation (GO:0033048)3.75764075
76negative regulation of chromosome segregation (GO:0051985)3.74120131
77phenol-containing compound catabolic process (GO:0019336)3.72450867
78lysine catabolic process (GO:0006554)3.70594939
79lysine metabolic process (GO:0006553)3.70594939
80regulation of chromatin silencing (GO:0031935)3.70557946
81regulation of apoptotic process involved in morphogenesis (GO:1902337)3.67879095
82somatic hypermutation of immunoglobulin genes (GO:0016446)3.63274731
83somatic diversification of immune receptors via somatic mutation (GO:0002566)3.63274731
84lung-associated mesenchyme development (GO:0060484)3.61912651
85regulation of telomere maintenance (GO:0032204)3.61766268
86hormone catabolic process (GO:0042447)3.61091050
87DNA strand elongation (GO:0022616)3.58923902
88rRNA modification (GO:0000154)3.57675870
89CENP-A containing nucleosome assembly (GO:0034080)3.56471272
90quinone metabolic process (GO:1901661)3.55709221
91intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.54486818
92purine nucleobase biosynthetic process (GO:0009113)3.53836452
93regulation of mitotic spindle checkpoint (GO:1903504)3.52858562
94regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.52858562
95nucleobase biosynthetic process (GO:0046112)3.51497138
96coenzyme catabolic process (GO:0009109)3.51295686
97trophectodermal cell differentiation (GO:0001829)3.49303614
98mitotic metaphase plate congression (GO:0007080)3.47148617
99regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.46794097
100mitotic spindle checkpoint (GO:0071174)3.45875587
101negative regulation of DNA-dependent DNA replication (GO:2000104)3.45532651
102DNA duplex unwinding (GO:0032508)3.45073227
103regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.43358140
104histone exchange (GO:0043486)3.42886822
105negative regulation of gene silencing (GO:0060969)3.41910780
106DNA geometric change (GO:0032392)3.41195616
107spindle checkpoint (GO:0031577)3.41095452
108cellular protein complex localization (GO:0034629)3.40586273
109pore complex assembly (GO:0046931)3.39995749
110DNA replication-independent nucleosome assembly (GO:0006336)3.39981238
111DNA replication-independent nucleosome organization (GO:0034724)3.39981238
112mitotic sister chromatid cohesion (GO:0007064)3.39233376
113intestinal epithelial cell development (GO:0060576)3.38229977
114RNA stabilization (GO:0043489)3.36792761
115mRNA stabilization (GO:0048255)3.36792761
116regulation of telomerase activity (GO:0051972)3.36351698
117regulation of hippo signaling (GO:0035330)3.34038016
118cardiovascular system development (GO:0072358)3.32013002
119microtubule severing (GO:0051013)3.30826006
120DNA unwinding involved in DNA replication (GO:0006268)3.30185152
121ATP-dependent chromatin remodeling (GO:0043044)3.29620294
122ribosome biogenesis (GO:0042254)3.27328549
123mitotic spindle assembly checkpoint (GO:0007094)3.27115852
124interferon-gamma production (GO:0032609)3.26673496
125regulation of sister chromatid segregation (GO:0033045)3.26380648
126regulation of mitotic sister chromatid separation (GO:0010965)3.26380648
127regulation of mitotic sister chromatid segregation (GO:0033047)3.26380648
128negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.25073001
129cullin deneddylation (GO:0010388)3.24423653
130maintenance of protein localization in organelle (GO:0072595)3.23759200
131regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.23528850
132regulation of mitotic metaphase/anaphase transition (GO:0030071)3.23528850
133regulation of chromosome segregation (GO:0051983)3.23271290
134telomere maintenance via telomerase (GO:0007004)3.20921616
135mitotic chromosome condensation (GO:0007076)3.17791567
136spindle assembly checkpoint (GO:0071173)3.17705620
137protein polyglutamylation (GO:0018095)3.17617928
138formation of translation preinitiation complex (GO:0001731)3.14679803
139anterior/posterior axis specification (GO:0009948)3.14305541
140intracellular estrogen receptor signaling pathway (GO:0030520)3.13723607
141bone trabecula formation (GO:0060346)3.12206448
142serine family amino acid biosynthetic process (GO:0009070)3.07993526
143non-recombinational repair (GO:0000726)3.07406484
144double-strand break repair via nonhomologous end joining (GO:0006303)3.07406484
145protein-DNA complex disassembly (GO:0032986)3.06807935
146nucleosome disassembly (GO:0006337)3.06807935
147regulation of gene silencing (GO:0060968)3.05197786
148regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04662211
149negative regulation of mitosis (GO:0045839)3.04542815
150regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.04242266
151regulation of SMAD protein import into nucleus (GO:0060390)3.04047756
152positive regulation of chromosome segregation (GO:0051984)3.03133673
153regulation of double-strand break repair (GO:2000779)3.02873442
154negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.02437056
155DNA damage response, detection of DNA damage (GO:0042769)3.00874823
156DNA replication initiation (GO:0006270)3.00688562
157retinoic acid receptor signaling pathway (GO:0048384)3.00242579
158intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.99597256
159regulation of cell fate commitment (GO:0010453)2.99572487
160positive regulation of protein deacetylation (GO:0090312)2.99086799
161ventricular system development (GO:0021591)2.98833631
162regulation of microtubule-based movement (GO:0060632)2.97405681
163ribosome assembly (GO:0042255)2.97122822
164negative regulation of DNA recombination (GO:0045910)2.95986224
165telomere maintenance via semi-conservative replication (GO:0032201)2.95701548
166spindle assembly (GO:0051225)2.95493374
167positive regulation of catenin import into nucleus (GO:0035413)2.92753098
168mitochondrion distribution (GO:0048311)2.92593672
169embryonic axis specification (GO:0000578)2.91417675
170histone arginine methylation (GO:0034969)2.91401152
171convergent extension (GO:0060026)2.90786094
172negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.90241989
173anterior/posterior axis specification, embryo (GO:0008595)2.90021588
174metaphase plate congression (GO:0051310)2.89629076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.80195434
2* KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.80195434
3* KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.80195434
4E2F7_22180533_ChIP-Seq_HELA_Human5.32617462
5BP1_19119308_ChIP-ChIP_Hs578T_Human5.01274375
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.61177717
7* NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.53319081
8* SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.25440623
9TP63_19390658_ChIP-ChIP_HaCaT_Human3.15067882
10* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.02905065
11* SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.00134449
12* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.96908148
13* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.75971603
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.72604400
15* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.63552135
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.58304122
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.43676921
18* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.38686335
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28029348
20* NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.18470961
21* NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.18086174
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.13769822
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.03338885
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01381464
25* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96464782
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96241392
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.95240832
28* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.93227892
29* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.90949118
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90189954
31* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.89250257
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.89180154
33* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.89099425
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85700402
35* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.84287091
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83302942
37* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.82266868
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79066848
39* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.77247977
40IRF1_19129219_ChIP-ChIP_H3396_Human1.74519916
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74216766
42* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.72629268
43* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68508649
44* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67646971
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67381170
46* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.64450004
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.60647770
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59057527
49* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.58200584
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57280991
51PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.56507820
52* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56015045
53* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55622879
54* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.54076365
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52695865
56* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.51647265
57* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.50707109
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.50515463
59* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.46078001
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42391376
61* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42228806
62TTF2_22483619_ChIP-Seq_HELA_Human1.40476500
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.40309398
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38063681
65* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.36563407
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.36114359
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35768846
68* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.33952381
69MYC_22102868_ChIP-Seq_BL_Human1.32902783
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.26589360
71* NANOG_16518401_ChIP-PET_MESCs_Mouse1.26504757
72GABP_17652178_ChIP-ChIP_JURKAT_Human1.25642120
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.25582058
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.25024182
75* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.21526875
76ELK1_19687146_ChIP-ChIP_HELA_Human1.21411728
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20457158
78* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.20002537
79* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18900510
80NANOG_16153702_ChIP-ChIP_HESCs_Human1.15338417
81CREB1_15753290_ChIP-ChIP_HEK293T_Human1.14415241
82ETS1_20019798_ChIP-Seq_JURKAT_Human1.13599771
83MYC_18940864_ChIP-ChIP_HL60_Human1.09143407
84* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08903071
85* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05053245
86* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04071084
87JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02906210
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02653075
89EWS_26573619_Chip-Seq_HEK293_Human1.02283029
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99332529
91FUS_26573619_Chip-Seq_HEK293_Human0.99322536
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98253528
93CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96942869
94SOX2_16153702_ChIP-ChIP_HESCs_Human0.96384981
95KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96204655
96POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95646595
97* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95575319
98WT1_19549856_ChIP-ChIP_CCG9911_Human0.95375127
99FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93861544
100EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92691091
101E2F1_18555785_ChIP-Seq_MESCs_Mouse0.91708510
102* KAP1_27257070_Chip-Seq_ESCs_Mouse0.91565868
103* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.91424074
104STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91208266
105* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90516479
106SALL1_21062744_ChIP-ChIP_HESCs_Human0.90307826
107NCOR1_26117541_ChIP-Seq_K562_Human0.90008452
108MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88360146
109EST1_17652178_ChIP-ChIP_JURKAT_Human0.86767109
110XRN2_22483619_ChIP-Seq_HELA_Human0.86589933
111EGR1_19374776_ChIP-ChIP_THP-1_Human0.85732563
112* TP53_22127205_ChIP-Seq_IMR90_Human0.84807985
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.83401656
114CDX2_20551321_ChIP-Seq_CACO-2_Human0.83385685
115KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.82604908
116ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.82268208
117KDM5A_27292631_Chip-Seq_BREAST_Human0.80979123
118NELFA_20434984_ChIP-Seq_ESCs_Mouse0.80503463
119SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.79967353
120ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79515894
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78301543
122NOTCH1_21737748_ChIP-Seq_TLL_Human0.77049560
123* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.76725275
124AR_21909140_ChIP-Seq_LNCAP_Human0.76302491
125* TCF7_22412390_ChIP-Seq_EML_Mouse0.75342395
126YY1_22570637_ChIP-Seq_MALME-3M_Human0.74741161
127* STAT3_18555785_ChIP-Seq_MESCs_Mouse0.74112744
128GATA1_26923725_Chip-Seq_HPCs_Mouse0.73961004
129CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.73931248
130* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.73792241
131KDM2B_26808549_Chip-Seq_SUP-B15_Human0.72600052
132FOXP3_21729870_ChIP-Seq_TREG_Human0.72598674

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development4.33122517
2MP0006292_abnormal_olfactory_placode4.13573763
3MP0004264_abnormal_extraembryonic_tissu3.90471120
4MP0003890_abnormal_embryonic-extraembry3.88181376
5MP0008877_abnormal_DNA_methylation3.75141281
6MP0003011_delayed_dark_adaptation3.56119153
7MP0008057_abnormal_DNA_replication3.52623648
8MP0002254_reproductive_system_inflammat3.50926831
9MP0005394_taste/olfaction_phenotype3.26462803
10MP0005499_abnormal_olfactory_system3.26462803
11MP0004957_abnormal_blastocyst_morpholog3.12969059
12MP0009672_abnormal_birth_weight3.08419779
13MP0002653_abnormal_ependyma_morphology3.00969754
14MP0004858_abnormal_nervous_system2.78702041
15MP0003122_maternal_imprinting2.75733882
16MP0005075_abnormal_melanosome_morpholog2.52860649
17MP0003121_genomic_imprinting2.50085528
18MP0002332_abnormal_exercise_endurance2.42404864
19MP0010352_gastrointestinal_tract_polyps2.33414658
20MP0003567_abnormal_fetal_cardiomyocyte2.28924744
21MP0001188_hyperpigmentation2.15761432
22MP0003718_maternal_effect2.13364923
23MP0003705_abnormal_hypodermis_morpholog2.09654171
24MP0005257_abnormal_intraocular_pressure2.07653497
25MP0010030_abnormal_orbit_morphology2.00947710
26* MP0001672_abnormal_embryogenesis/_devel1.98370949
27* MP0005380_embryogenesis_phenotype1.98370949
28MP0001293_anophthalmia1.97048570
29MP0003077_abnormal_cell_cycle1.84545433
30MP0004133_heterotaxia1.82147711
31MP0006035_abnormal_mitochondrial_morpho1.81744399
32MP0000350_abnormal_cell_proliferation1.77945933
33MP0003938_abnormal_ear_development1.77534995
34* MP0002088_abnormal_embryonic_growth/wei1.75729547
35* MP0003984_embryonic_growth_retardation1.74810558
36MP0003123_paternal_imprinting1.72540125
37MP0001849_ear_inflammation1.72434299
38MP0003111_abnormal_nucleus_morphology1.70410830
39* MP0002085_abnormal_embryonic_tissue1.65061342
40MP0010094_abnormal_chromosome_stability1.63534797
41MP0002084_abnormal_developmental_patter1.62471044
42MP0003119_abnormal_digestive_system1.59198662
43MP0008789_abnormal_olfactory_epithelium1.55337391
44MP0002127_abnormal_cardiovascular_syste1.55329320
45MP0002086_abnormal_extraembryonic_tissu1.51222787
46MP0002092_abnormal_eye_morphology1.49342629
47MP0008961_abnormal_basal_metabolism1.47754181
48MP0000762_abnormal_tongue_morphology1.47436767
49MP0000579_abnormal_nail_morphology1.47366506
50MP0001299_abnormal_eye_distance/1.46420019
51MP0000537_abnormal_urethra_morphology1.44915423
52MP0001730_embryonic_growth_arrest1.41690691
53MP0002277_abnormal_respiratory_mucosa1.39791699
54MP0004197_abnormal_fetal_growth/weight/1.38933020
55MP0010307_abnormal_tumor_latency1.37674395
56MP0000566_synostosis1.32305729
57MP0002233_abnormal_nose_morphology1.31460136
58MP0003283_abnormal_digestive_organ1.27565463
59MP0001348_abnormal_lacrimal_gland1.26216400
60MP0000432_abnormal_head_morphology1.25340243
61MP0008932_abnormal_embryonic_tissue1.24975368
62MP0001697_abnormal_embryo_size1.21584207
63MP0005266_abnormal_metabolism1.21101646
64MP0002938_white_spotting1.18587077
65MP0005377_hearing/vestibular/ear_phenot1.18314220
66MP0003878_abnormal_ear_physiology1.18314220
67MP0000428_abnormal_craniofacial_morphol1.17156362
68MP0003787_abnormal_imprinting1.15679398
69MP0001177_atelectasis1.14977970
70MP0005623_abnormal_meninges_morphology1.10626577
71* MP0002114_abnormal_axial_skeleton1.08408485
72* MP0002080_prenatal_lethality1.05754233
73MP0002249_abnormal_larynx_morphology1.04203701
74* MP0003935_abnormal_craniofacial_develop1.01061907
75MP0005391_vision/eye_phenotype1.00532146
76MP0000313_abnormal_cell_death0.99625295
77MP0008007_abnormal_cellular_replicative0.98931859
78* MP0003755_abnormal_palate_morphology0.98298609
79MP0009703_decreased_birth_body0.98239666
80MP0003861_abnormal_nervous_system0.98143772
81MP0008770_decreased_survivor_rate0.97340532
82* MP0002932_abnormal_joint_morphology0.96303071
83MP0003693_abnormal_embryo_hatching0.94805177
84MP0003136_yellow_coat_color0.94305949
85MP0002751_abnormal_autonomic_nervous0.94304812
86MP0004270_analgesia0.92662286
87MP0003183_abnormal_peptide_metabolism0.91916767
88MP0005248_abnormal_Harderian_gland0.89611691
89MP0002396_abnormal_hematopoietic_system0.89206810
90* MP0002925_abnormal_cardiovascular_devel0.88346122
91MP0002796_impaired_skin_barrier0.88250099
92MP0003315_abnormal_perineum_morphology0.88235966
93MP0001485_abnormal_pinna_reflex0.85741273
94* MP0000049_abnormal_middle_ear0.85406473
95MP0004043_abnormal_pH_regulation0.85094106
96MP0002970_abnormal_white_adipose0.83879669
97MP0006082_CNS_inflammation0.83292898
98MP0009697_abnormal_copulation0.82411961
99MP0002090_abnormal_vision0.82164071
100MP0003137_abnormal_impulse_conducting0.81235879
101MP0009278_abnormal_bone_marrow0.80504352
102* MP0002116_abnormal_craniofacial_bone0.79917776
103MP0001984_abnormal_olfaction0.79557814
104MP0004859_abnormal_synaptic_plasticity0.79524776
105MP0003115_abnormal_respiratory_system0.79439799
106MP0002736_abnormal_nociception_after0.78694005
107MP0002111_abnormal_tail_morphology0.78133019
108MP0006072_abnormal_retinal_apoptosis0.78046716
109MP0008058_abnormal_DNA_repair0.77152790
110MP0002210_abnormal_sex_determination0.74242443
111MP0004272_abnormal_basement_membrane0.74204920
112MP0002697_abnormal_eye_size0.74131055
113* MP0002081_perinatal_lethality0.72397503
114MP0000490_abnormal_crypts_of0.72156124
115MP0000750_abnormal_muscle_regeneration0.71070277
116MP0002269_muscular_atrophy0.70078295
117MP0003786_premature_aging0.69516444
118MP0005023_abnormal_wound_healing0.69213258
119MP0001145_abnormal_male_reproductive0.69013024
120* MP0001286_abnormal_eye_development0.68996886
121* MP0003937_abnormal_limbs/digits/tail_de0.66938712
122MP0002152_abnormal_brain_morphology0.64281362
123MP0001915_intracranial_hemorrhage0.63193333
124MP0001929_abnormal_gametogenesis0.62568034
125MP0001529_abnormal_vocalization0.61693247
126MP0000358_abnormal_cell_content/0.60720291
127MP0000631_abnormal_neuroendocrine_gland0.60477718
128MP0005384_cellular_phenotype0.59532870
129MP0005410_abnormal_fertilization0.59481827
130MP0000653_abnormal_sex_gland0.59272800
131MP0003942_abnormal_urinary_system0.59082587
132MP0001661_extended_life_span0.58827116
133MP0004233_abnormal_muscle_weight0.57902015
134MP0002098_abnormal_vibrissa_morphology0.57473473
135MP0002752_abnormal_somatic_nervous0.56703865
136MP0005253_abnormal_eye_physiology0.56091232
137MP0005395_other_phenotype0.55814249
138MP0001346_abnormal_lacrimal_gland0.55065687
139MP0000647_abnormal_sebaceous_gland0.54885117
140MP0000955_abnormal_spinal_cord0.51700596

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.85891695
2Hypochromic microcytic anemia (HP:0004840)5.10189493
3Ependymoma (HP:0002888)5.01652795
4Rib fusion (HP:0000902)4.93183172
5Abnormality of the lower motor neuron (HP:0002366)4.88201341
6Hepatoblastoma (HP:0002884)4.83762622
7Colon cancer (HP:0003003)4.75252824
8Multiple enchondromatosis (HP:0005701)4.25278034
9Neoplasm of striated muscle (HP:0009728)4.00238347
10Spastic diplegia (HP:0001264)3.86265772
11Rhabdomyosarcoma (HP:0002859)3.81338554
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.71196441
13Abnormality of the astrocytes (HP:0100707)3.67414075
14Astrocytoma (HP:0009592)3.67414075
15Nephroblastoma (Wilms tumor) (HP:0002667)3.67390830
16Septo-optic dysplasia (HP:0100842)3.60570427
17Rectal fistula (HP:0100590)3.51877992
18Rectovaginal fistula (HP:0000143)3.51877992
19Choanal stenosis (HP:0000452)3.45247384
20Cortical dysplasia (HP:0002539)3.42732479
21Embryonal renal neoplasm (HP:0011794)3.41465664
22Fused cervical vertebrae (HP:0002949)3.28348984
23Partial duplication of thumb phalanx (HP:0009944)3.25014816
24Chromsome breakage (HP:0040012)3.24948928
25Aplasia/hypoplasia of the humerus (HP:0006507)3.20865710
26Abnormality of the salivary glands (HP:0010286)3.19843878
27Short humerus (HP:0005792)3.18497741
28Intestinal fistula (HP:0100819)3.16314606
29Bifid tongue (HP:0010297)3.13760017
30Birth length less than 3rd percentile (HP:0003561)3.12261643
31Abnormal lung lobation (HP:0002101)2.99697782
32Vaginal fistula (HP:0004320)2.98990513
33Amyotrophic lateral sclerosis (HP:0007354)2.98935093
34Aplasia/Hypoplasia of the fovea (HP:0008060)2.92574006
35Hypoplasia of the fovea (HP:0007750)2.92574006
36Supernumerary spleens (HP:0009799)2.90059053
37Partial duplication of the phalanx of hand (HP:0009999)2.87304826
38Abnormal hair whorl (HP:0010721)2.84667338
39Glioma (HP:0009733)2.73386132
40Shawl scrotum (HP:0000049)2.71063834
41Large earlobe (HP:0009748)2.70566104
42Increased nuchal translucency (HP:0010880)2.67915222
43Chronic bronchitis (HP:0004469)2.67822916
44Impulsivity (HP:0100710)2.63482075
45Neoplasm of the adrenal cortex (HP:0100641)2.62549262
46Trismus (HP:0000211)2.62067759
47Anomalous pulmonary venous return (HP:0010772)2.60250495
48Testicular atrophy (HP:0000029)2.56881547
49Medulloblastoma (HP:0002885)2.55176214
50Hypoglycemic seizures (HP:0002173)2.54230006
51Preauricular skin tag (HP:0000384)2.53010570
52Agnosia (HP:0010524)2.52926831
53Hyperinsulinemic hypoglycemia (HP:0000825)2.52298417
54Selective tooth agenesis (HP:0001592)2.46942179
55Abnormality of homocysteine metabolism (HP:0010919)2.43054235
56Homocystinuria (HP:0002156)2.43054235
57Aplasia/Hypoplasia of the sternum (HP:0006714)2.41039351
58Aqueductal stenosis (HP:0002410)2.39244495
59Abnormality of chromosome segregation (HP:0002916)2.37855274
60Malignant gastrointestinal tract tumors (HP:0006749)2.37574813
61Gastrointestinal carcinoma (HP:0002672)2.37574813
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.36364731
63Meckel diverticulum (HP:0002245)2.36187518
64Abnormality of the phalanges of the hallux (HP:0010057)2.35078869
65Stenosis of the external auditory canal (HP:0000402)2.34441779
66Horizontal nystagmus (HP:0000666)2.32827701
67Generalized hypotonia (HP:0001290)2.30223801
68Skin tags (HP:0010609)2.29917477
69Neoplasm of the oral cavity (HP:0100649)2.29809072
70Abnormality of the septum pellucidum (HP:0007375)2.28819598
71Pseudobulbar signs (HP:0002200)2.28696733
72Maternal diabetes (HP:0009800)2.28124970
73Neoplasm of the heart (HP:0100544)2.26107419
74Hyperglycinemia (HP:0002154)2.25855384
75Skull defect (HP:0001362)2.25023926
76Absent radius (HP:0003974)2.24895126
77Ragged-red muscle fibers (HP:0003200)2.23878602
78Neoplasm of the colon (HP:0100273)2.23843093
79Hypopigmentation of the fundus (HP:0007894)2.23741655
80Abnormality of the musculature of the hand (HP:0001421)2.23290642
81Abnormality of the distal phalanx of the thumb (HP:0009617)2.22821543
82Abnormality of the ileum (HP:0001549)2.22523875
83Hyperglycinuria (HP:0003108)2.20626000
84Vertebral fusion (HP:0002948)2.20135688
85Biliary tract neoplasm (HP:0100574)2.19477526
86Absent septum pellucidum (HP:0001331)2.18702517
87Intestinal atresia (HP:0011100)2.18658952
88Abnormality of the pubic bones (HP:0003172)2.17848656
89Abnormality of the pulmonary veins (HP:0011718)2.17708988
90Preauricular pit (HP:0004467)2.17621267
91Periauricular skin pits (HP:0100277)2.17621267
92Supernumerary ribs (HP:0005815)2.16651521
93Abnormality of the fovea (HP:0000493)2.14907169
94Turricephaly (HP:0000262)2.14693978
95Missing ribs (HP:0000921)2.14240107
96Breast aplasia (HP:0100783)2.14233210
97Abnormality of serine family amino acid metabolism (HP:0010894)2.14169783
98Abnormality of glycine metabolism (HP:0010895)2.14169783
99Renal duplication (HP:0000075)2.13888232
100Ectopic kidney (HP:0000086)2.13066407
101Sensory axonal neuropathy (HP:0003390)2.12644121
102Pancreatic islet-cell hyperplasia (HP:0004510)2.12583605
103Carpal bone hypoplasia (HP:0001498)2.11448638
104Aplasia involving forearm bones (HP:0009822)2.10327417
105Absent forearm bone (HP:0003953)2.10327417
106Abnormality of the labia minora (HP:0012880)2.08833669
107Short 5th finger (HP:0009237)2.08722442
108Bronchomalacia (HP:0002780)2.07895324
109Malignant neoplasm of the central nervous system (HP:0100836)2.07566204
110Esophageal atresia (HP:0002032)2.07368957
111Abnormal cartilage morphology (HP:0002763)2.06643708
112Hand muscle atrophy (HP:0009130)2.05957039
113Clitoromegaly (HP:0000057)2.02431771
114Aplasia/Hypoplasia of the breasts (HP:0010311)2.02404041
115Abnormality of chromosome stability (HP:0003220)2.02369383
116Duplication of thumb phalanx (HP:0009942)2.02020474
117Cutaneous syndactyly (HP:0012725)2.01723372
118Abnormality of the clitoris (HP:0000056)2.01131180
119Tongue fasciculations (HP:0001308)1.99621888
120Absent eyebrow (HP:0002223)1.99004722
121Difficulty running (HP:0009046)1.98877138
122Trigonocephaly (HP:0000243)1.98738049
123Supernumerary bones of the axial skeleton (HP:0009144)1.97088162
124Aplasia/Hypoplasia of the macula (HP:0008059)1.96747010
125Abnormality of serum amino acid levels (HP:0003112)1.96674338
126Small intestinal stenosis (HP:0012848)1.96615105
127Duodenal stenosis (HP:0100867)1.96615105
128Myelomeningocele (HP:0002475)1.96040161
129Facial cleft (HP:0002006)1.95695683
130Atresia of the external auditory canal (HP:0000413)1.95191841
131Uterine neoplasm (HP:0010784)1.95116357
132Short hallux (HP:0010109)1.95106856
133Prominent occiput (HP:0000269)1.95054568
134Atrophy/Degeneration involving motor neurons (HP:0007373)1.94728722
135Hypoplastic female external genitalia (HP:0012815)1.94592507
136Nasolacrimal duct obstruction (HP:0000579)1.93619297
137Upper motor neuron abnormality (HP:0002127)1.93429220
138Abnormality of the duodenum (HP:0002246)1.92253562
139Horseshoe kidney (HP:0000085)1.91895041
140Absent eyelashes (HP:0000561)1.90464803
141Neoplasm of the adrenal gland (HP:0100631)1.90156386
142Hyperventilation (HP:0002883)1.89615266
143Neuroblastic tumors (HP:0004376)1.89393200
144Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.89393200
145Neuroblastoma (HP:0003006)1.89393200
146Primitive neuroectodermal tumor (HP:0030065)1.89393200
147Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.89100866
148Aplasia/Hypoplasia of the hallux (HP:0008362)1.88657188
149Hypochromic anemia (HP:0001931)1.88311235
150Adenoma sebaceum (HP:0009720)1.87176488
151Angiofibromas (HP:0010615)1.87176488
152Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86948734
153Skin pits (HP:0100276)1.86181533
154Broad thumb (HP:0011304)1.84638643
155Glossoptosis (HP:0000162)1.84193060
156Embryonal neoplasm (HP:0002898)1.82721232
157Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.82467350
158Gastrointestinal atresia (HP:0002589)1.81599471
159Tetraplegia (HP:0002445)1.81297600
160Cutaneous finger syndactyly (HP:0010554)1.81270436
161Progressive muscle weakness (HP:0003323)1.80862323
162Abnormality of abdominal situs (HP:0011620)1.79956911
163Abdominal situs inversus (HP:0003363)1.79956911
164Supernumerary nipples (HP:0002558)1.79739721
165High anterior hairline (HP:0009890)1.79312495
166Preaxial foot polydactyly (HP:0001841)1.79020605
167Shallow orbits (HP:0000586)1.78782670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.71122933
2GRK54.95961891
3GRK64.08571881
4TSSK63.75543021
5ERN13.50343290
6MKNK13.20499541
7MKNK23.00375730
8ADRBK22.98685486
9GRK12.98064199
10TTK2.89264199
11TAF12.88889777
12TYRO32.86144626
13TNIK2.82503703
14VRK22.51945633
15PLK32.51166174
16CSF1R2.47446419
17CDK192.31780480
18ZAK2.26239007
19MAPK72.13439442
20SMG12.10443637
21STK102.08043147
22TGFBR22.06538894
23GRK72.05822585
24PASK2.05307661
25WNK12.04821253
26EPHA21.92334984
27FGFR21.83737092
28CDK71.83519865
29MATK1.79843536
30MOS1.70322517
31PLK41.64120612
32CDC71.44370175
33CHEK21.41305912
34BRSK21.41298009
35NUAK11.39193021
36STK38L1.39067677
37MAP3K101.37866598
38CAMK41.36437303
39PAK41.34996695
40AKT31.31956139
41EEF2K1.31510098
42WNK31.31403639
43MARK21.30073546
44PLK11.28016460
45PRKG21.26117864
46FGFR11.25973525
47NTRK11.23601814
48PBK1.20617977
49CASK1.19528952
50CAMK1G1.17222720
51NLK1.14936264
52CAMK1D1.12469791
53ALK1.11665546
54TRIM281.08888269
55VRK11.05848469
56CHEK11.02357880
57PNCK1.02333433
58ADRBK11.00484535
59HIPK21.00406017
60ICK0.99030094
61MST40.96192891
62NEK20.93047442
63STK30.92749031
64CSNK1G10.92255142
65LATS20.91229242
66NME10.90749798
67ERBB40.84221563
68BRSK10.82159896
69RPS6KB20.81492174
70AKT20.81471795
71MAP2K40.80695582
72WEE10.80099367
73MTOR0.78891365
74STK240.73528258
75ACVR1B0.73258875
76MAP3K90.72294219
77BUB10.69963091
78BRD40.69389269
79PRKDC0.67582102
80CDK20.66746188
81FGFR30.66731403
82FGFR40.64416743
83DAPK10.62671018
84OXSR10.61374848
85AURKA0.60170197
86PRKCI0.59647464
87TIE10.59197502
88TGFBR10.59117190
89MAP2K60.58023739
90CSNK1G20.56860144
91BMPR1B0.55865627
92MAP3K70.55756249
93ATM0.55127620
94CDK40.54873267
95NEK10.54751934
96YES10.53991878
97STK160.52382461
98BCR0.50979387
99CSNK1E0.49993527
100DYRK20.49248136
101CSK0.47336402
102CDK60.46871756
103FLT30.46578245
104DYRK30.46424679
105DMPK0.45707903
106PTK20.44948786
107AURKB0.44277253
108EGFR0.43911371
109EIF2AK20.43644142
110PAK10.43282966
111CDK10.43167746
112CSNK1G30.42451170
113SRPK10.40419098
114MAPK120.39235656
115MAPK100.39156576
116BMX0.38831362
117CDK30.38686564
118MET0.38604183
119PLK20.38291185
120FGR0.38229247
121RPS6KA40.35596171
122PRPF4B0.35463896
123GSK3B0.34747573
124PDGFRA0.33358435
125MAP3K40.31591543
126RPS6KA10.31443630
127MAPK10.31125147
128PIM10.31112703
129CSNK2A10.31024119
130CDK150.30737583
131TESK20.30494893
132MAPK140.29983597
133PAK60.29545307
134CDK11A0.28976800
135CSNK1D0.28471735
136ATR0.27657325
137STK380.26843191
138CDK180.26535828
139IGF1R0.25358072
140ERBB20.25309967
141DYRK1A0.24986665
142PRKD30.24081482
143INSR0.22254972
144RIPK10.21175172
145MAPKAPK30.21008345
146PRKD20.20462456
147UHMK10.20222435
148CDK140.19994184
149NTRK20.19670443
150DDR20.19610947
151MAP3K80.18840629
152STK40.18615352
153GSK3A0.18050481
154PRKCD0.17989601
155PRKACB0.16867216
156PAK30.15783230
157RPS6KA30.14995568
158AKT10.14894945
159LATS10.14137924

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.60059200
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.24359243
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.51026232
4Fructose and mannose metabolism_Homo sapiens_hsa000513.35196306
5RNA transport_Homo sapiens_hsa030132.56396013
6Arachidonic acid metabolism_Homo sapiens_hsa005902.31679155
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.25888148
8mRNA surveillance pathway_Homo sapiens_hsa030152.20875813
9Galactose metabolism_Homo sapiens_hsa000522.07141852
10Mismatch repair_Homo sapiens_hsa034302.05202099
11Linoleic acid metabolism_Homo sapiens_hsa005912.01678104
12DNA replication_Homo sapiens_hsa030301.99567801
13Proteasome_Homo sapiens_hsa030501.93781545
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.87515853
15Fanconi anemia pathway_Homo sapiens_hsa034601.87376200
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83805048
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83479087
18One carbon pool by folate_Homo sapiens_hsa006701.77767445
19Spliceosome_Homo sapiens_hsa030401.76341912
20Cell cycle_Homo sapiens_hsa041101.73138367
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.72554477
22mTOR signaling pathway_Homo sapiens_hsa041501.63333818
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62894696
24Thyroid cancer_Homo sapiens_hsa052161.59588110
25Basal cell carcinoma_Homo sapiens_hsa052171.56813099
26Homologous recombination_Homo sapiens_hsa034401.51042913
27RNA degradation_Homo sapiens_hsa030181.46662852
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45676227
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42919210
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40122108
31Hedgehog signaling pathway_Homo sapiens_hsa043401.35633185
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30167798
33Propanoate metabolism_Homo sapiens_hsa006401.24963460
34Pyruvate metabolism_Homo sapiens_hsa006201.21691758
35Steroid biosynthesis_Homo sapiens_hsa001001.20213899
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20123261
37Ribosome_Homo sapiens_hsa030101.19207759
38Hippo signaling pathway_Homo sapiens_hsa043901.16763348
39MicroRNAs in cancer_Homo sapiens_hsa052061.07820558
40Base excision repair_Homo sapiens_hsa034101.05488100
41Basal transcription factors_Homo sapiens_hsa030221.03723458
42Ether lipid metabolism_Homo sapiens_hsa005651.03322587
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01502978
44RNA polymerase_Homo sapiens_hsa030201.00218325
45Purine metabolism_Homo sapiens_hsa002300.99779447
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98986207
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97758203
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96384672
49Central carbon metabolism in cancer_Homo sapiens_hsa052300.95857788
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.94048962
51Notch signaling pathway_Homo sapiens_hsa043300.93052578
52p53 signaling pathway_Homo sapiens_hsa041150.91729026
53Pathways in cancer_Homo sapiens_hsa052000.91571080
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91445927
55Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89960142
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86182152
57Inositol phosphate metabolism_Homo sapiens_hsa005620.84213746
58Fatty acid elongation_Homo sapiens_hsa000620.81756877
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80424350
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80025019
61Wnt signaling pathway_Homo sapiens_hsa043100.79875328
62Vitamin digestion and absorption_Homo sapiens_hsa049770.79426434
63Non-homologous end-joining_Homo sapiens_hsa034500.78228332
64Tight junction_Homo sapiens_hsa045300.74792005
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74316520
66Ovarian steroidogenesis_Homo sapiens_hsa049130.74296239
67Nucleotide excision repair_Homo sapiens_hsa034200.74176593
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73985762
69Choline metabolism in cancer_Homo sapiens_hsa052310.71428241
70Nicotine addiction_Homo sapiens_hsa050330.69612042
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67514093
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67412719
73Rap1 signaling pathway_Homo sapiens_hsa040150.66535154
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64905332
75Acute myeloid leukemia_Homo sapiens_hsa052210.63805618
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61701460
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61027710
78Protein export_Homo sapiens_hsa030600.59963212
79Bladder cancer_Homo sapiens_hsa052190.58926227
80Biosynthesis of amino acids_Homo sapiens_hsa012300.58000452
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57008374
82Arginine and proline metabolism_Homo sapiens_hsa003300.56960311
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56360646
84Adherens junction_Homo sapiens_hsa045200.56352084
85Oocyte meiosis_Homo sapiens_hsa041140.54496943
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54257090
87Chemical carcinogenesis_Homo sapiens_hsa052040.53614871
88Prostate cancer_Homo sapiens_hsa052150.52905080
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52685742
90Other glycan degradation_Homo sapiens_hsa005110.52590553
91Non-small cell lung cancer_Homo sapiens_hsa052230.52062640
92Pentose phosphate pathway_Homo sapiens_hsa000300.50384571
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48569832
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.46954554
95Proteoglycans in cancer_Homo sapiens_hsa052050.45396414
96AMPK signaling pathway_Homo sapiens_hsa041520.44393380
97Lysine degradation_Homo sapiens_hsa003100.43884971
98Colorectal cancer_Homo sapiens_hsa052100.42874126
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42434763
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41620591
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.41289434
102Herpes simplex infection_Homo sapiens_hsa051680.40447291
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40402326
104Viral carcinogenesis_Homo sapiens_hsa052030.40181916
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39669835
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.38860594
107TGF-beta signaling pathway_Homo sapiens_hsa043500.37910660
108beta-Alanine metabolism_Homo sapiens_hsa004100.37348782
109HTLV-I infection_Homo sapiens_hsa051660.37054086
110Ras signaling pathway_Homo sapiens_hsa040140.35568190
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35261157
112VEGF signaling pathway_Homo sapiens_hsa043700.35238245
113Pyrimidine metabolism_Homo sapiens_hsa002400.35202394
114Fatty acid metabolism_Homo sapiens_hsa012120.34257505
115Endometrial cancer_Homo sapiens_hsa052130.33194004
116Carbon metabolism_Homo sapiens_hsa012000.32696267
117African trypanosomiasis_Homo sapiens_hsa051430.32395632
118Glutathione metabolism_Homo sapiens_hsa004800.30653371
119Dorso-ventral axis formation_Homo sapiens_hsa043200.30605195
120Metabolic pathways_Homo sapiens_hsa011000.30529661
121Long-term depression_Homo sapiens_hsa047300.30085850
122Melanogenesis_Homo sapiens_hsa049160.29085229
123Folate biosynthesis_Homo sapiens_hsa007900.27142415
124Arginine biosynthesis_Homo sapiens_hsa002200.26585126
125Selenocompound metabolism_Homo sapiens_hsa004500.25819576
126Serotonergic synapse_Homo sapiens_hsa047260.23852929
127Taste transduction_Homo sapiens_hsa047420.23278974
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.23068804
129Huntingtons disease_Homo sapiens_hsa050160.22617493
130Glutamatergic synapse_Homo sapiens_hsa047240.22453918
131Glucagon signaling pathway_Homo sapiens_hsa049220.21657175
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.21461839
133Axon guidance_Homo sapiens_hsa043600.21335087
134Epstein-Barr virus infection_Homo sapiens_hsa051690.21286365
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19881299
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18457812
137Melanoma_Homo sapiens_hsa052180.13282809
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12991284
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.10451229
140Phototransduction_Homo sapiens_hsa047440.10434208
141Gap junction_Homo sapiens_hsa045400.10009783

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