PHC1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)8.43480532
2regulation of gene silencing by miRNA (GO:0060964)8.43480532
3regulation of gene silencing by RNA (GO:0060966)8.43480532
4pre-miRNA processing (GO:0031054)6.48456195
5positive regulation of SMAD protein import into nucleus (GO:0060391)5.80217818
6heterochromatin organization (GO:0070828)5.52141993
7paraxial mesoderm development (GO:0048339)5.49187963
8L-serine metabolic process (GO:0006563)5.33602494
9protein complex localization (GO:0031503)5.16916374
10regulation of histone H3-K9 methylation (GO:0051570)5.12915524
11establishment of integrated proviral latency (GO:0075713)5.07386611
12L-alpha-amino acid transmembrane transport (GO:1902475)5.06754192
13negative regulation of histone methylation (GO:0031061)5.04016082
14histone arginine methylation (GO:0034969)4.96839313
15nuclear pore complex assembly (GO:0051292)4.81592518
16DNA unwinding involved in DNA replication (GO:0006268)4.79329299
17regulation of cell fate specification (GO:0042659)4.76912099
18negative regulation of gene silencing (GO:0060969)4.73984581
19regulation of gene silencing (GO:0060968)4.71158984
20regulation of chromatin silencing (GO:0031935)4.63374853
21protein-DNA complex disassembly (GO:0032986)4.38248707
22nucleosome disassembly (GO:0006337)4.38248707
23protein localization to kinetochore (GO:0034501)4.28859311
24nuclear pore organization (GO:0006999)4.27218892
25regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.26476870
26peptidyl-arginine omega-N-methylation (GO:0035247)4.05844937
27regulation of SMAD protein import into nucleus (GO:0060390)4.03968398
28convergent extension (GO:0060026)4.03644060
29negative regulation of translation, ncRNA-mediated (GO:0040033)3.97090951
30regulation of translation, ncRNA-mediated (GO:0045974)3.97090951
31negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.97090951
32lung-associated mesenchyme development (GO:0060484)3.94996654
33cell fate commitment involved in formation of primary germ layer (GO:0060795)3.84659122
34positive regulation of catenin import into nucleus (GO:0035413)3.79157508
35establishment of viral latency (GO:0019043)3.75328235
36IMP biosynthetic process (GO:0006188)3.65917517
37planar cell polarity pathway involved in neural tube closure (GO:0090179)3.59624366
38peptidyl-arginine methylation (GO:0018216)3.52499723
39peptidyl-arginine N-methylation (GO:0035246)3.52499723
40regulation of stem cell maintenance (GO:2000036)3.48742369
41IMP metabolic process (GO:0046040)3.48404516
42protein localization to chromosome, centromeric region (GO:0071459)3.45457757
43negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.41524748
44cellular protein complex localization (GO:0034629)3.38261705
45histone H3-K36 demethylation (GO:0070544)3.34462331
46glomerular visceral epithelial cell development (GO:0072015)3.33275682
47regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.32673502
48pore complex assembly (GO:0046931)3.31239286
49regulation of telomere maintenance via telomerase (GO:0032210)3.25662775
50negative regulation of androgen receptor signaling pathway (GO:0060766)3.25129999
51chromatin silencing (GO:0006342)3.23684919
52lysine metabolic process (GO:0006553)3.23054906
53lysine catabolic process (GO:0006554)3.23054906
54DNA strand elongation involved in DNA replication (GO:0006271)3.22961842
55DNA duplex unwinding (GO:0032508)3.22504179
56regulation of translational fidelity (GO:0006450)3.20188955
57chromatin assembly (GO:0031497)3.19310587
58DNA geometric change (GO:0032392)3.09827602
59regulation of helicase activity (GO:0051095)3.09106394
60DNA strand elongation (GO:0022616)3.08678464
61mitotic sister chromatid cohesion (GO:0007064)3.08565861
62serine family amino acid biosynthetic process (GO:0009070)3.03500621
63RNA stabilization (GO:0043489)2.97680728
64mRNA stabilization (GO:0048255)2.97680728
65negative regulation of mRNA processing (GO:0050686)2.95660653
66regulation of cell fate commitment (GO:0010453)2.94311137
67notochord development (GO:0030903)2.93758735
68glomerular epithelial cell development (GO:0072310)2.93748417
69somatic stem cell division (GO:0048103)2.92793195
70generation of neurons (GO:0048699)2.90707637
71positive regulation of chromosome segregation (GO:0051984)2.90538987
72ATP-dependent chromatin remodeling (GO:0043044)2.89384462
73single strand break repair (GO:0000012)2.86828884
74positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.85123465
75positive regulation of cell cycle G2/M phase transition (GO:1902751)2.85123465
76negative regulation of cell fate specification (GO:0009996)2.83655359
77establishment of apical/basal cell polarity (GO:0035089)2.83454893
78negative regulation of mRNA metabolic process (GO:1903312)2.81038543
79DNA replication initiation (GO:0006270)2.78995331
80anterior/posterior axis specification, embryo (GO:0008595)2.76726620
81somatic diversification of immune receptors via somatic mutation (GO:0002566)2.74135893
82somatic hypermutation of immunoglobulin genes (GO:0016446)2.74135893
83regulation of mRNA stability (GO:0043488)2.74058768
84negative regulation of chromosome segregation (GO:0051985)2.73715890
85regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.72074432
86positive regulation of gene expression, epigenetic (GO:0045815)2.68511231
87negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.67693568
88negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.67693568
89negative regulation of mitotic sister chromatid segregation (GO:0033048)2.67693568
90negative regulation of mitotic sister chromatid separation (GO:2000816)2.67693568
91negative regulation of sister chromatid segregation (GO:0033046)2.67693568
92presynaptic membrane assembly (GO:0097105)2.67137619
93negative regulation of RNA splicing (GO:0033119)2.66774883
94negative regulation of telomerase activity (GO:0051974)2.66748008
95DNA replication-dependent nucleosome assembly (GO:0006335)2.64700636
96DNA replication-dependent nucleosome organization (GO:0034723)2.64700636
97regulation of NFAT protein import into nucleus (GO:0051532)2.64082789
98glutamine metabolic process (GO:0006541)2.61463174
99mitotic nuclear envelope disassembly (GO:0007077)2.61094583
100regulation of catenin import into nucleus (GO:0035412)2.60549577

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.97354992
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.99228844
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.99228844
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.99228844
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.26046094
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.25848033
7POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.25497075
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.10697308
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.96359120
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79024084
11NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.62593743
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.53901683
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.47897069
14ZFP281_18757296_ChIP-ChIP_E14_Mouse2.33702400
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31269083
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.30772859
17TCF3_18692474_ChIP-Seq_MEFs_Mouse2.26205798
18SOX2_16153702_ChIP-ChIP_HESCs_Human2.24140829
19SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.22851502
20MYC_22102868_ChIP-Seq_BL_Human2.12790570
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.09510524
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07235766
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04407683
24ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.00012100
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.98582973
26SOX2_18555785_ChIP-Seq_MESCs_Mouse1.97954208
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.96717743
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.93196458
29NANOG_16153702_ChIP-ChIP_HESCs_Human1.92249517
30TCF3_18692474_ChIP-Seq_MESCs_Mouse1.89508311
31DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.88875762
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.87636499
33CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.86379491
34SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.85725774
35NANOG_21062744_ChIP-ChIP_HESCs_Human1.85456270
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82565164
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.79057638
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77300500
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73328608
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72765332
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72711223
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70798414
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70153965
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58360173
45NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.57371295
46SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.55797675
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55750810
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52500428
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50466793
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48624902
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.46315514
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45468261
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.44092117
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43973800
55POU5F1_16518401_ChIP-PET_MESCs_Mouse1.42095779
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.38279485
57ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37778410
58HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.37434833
59TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.37043962
60POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.34366325
61SOX2_18692474_ChIP-Seq_MESCs_Mouse1.34294769
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.33971408
63XRN2_22483619_ChIP-Seq_HELA_Human1.33675614
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33599557
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33334905
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31385614
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31311210
68KAP1_27257070_Chip-Seq_ESCs_Mouse1.28384771
69CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28167714
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28022320
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.27136304
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25235534
73NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.21740986
74SOX2_18692474_ChIP-Seq_MEFs_Mouse1.21582597
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19407057
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16729947
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14855777
78PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.14017934
79ERG_21242973_ChIP-ChIP_JURKAT_Human1.12608596
80POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.11767743
81OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10412823
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10196474
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09854684
84TTF2_22483619_ChIP-Seq_HELA_Human1.09183246
85WT1_19549856_ChIP-ChIP_CCG9911_Human1.09092421
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07622833
87TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03809806
88YY1_21170310_ChIP-Seq_MESCs_Mouse1.03528528
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02866682
90TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02672425
91NANOG_18692474_ChIP-Seq_MESCs_Mouse1.02215354
92TP63_19390658_ChIP-ChIP_HaCaT_Human1.01539583
93ISL1_27105846_Chip-Seq_CPCs_Mouse1.00765834
94CLOCK_20551151_ChIP-Seq_293T_Human0.96865616
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96837359
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96695891
97NANOG_18692474_ChIP-Seq_MEFs_Mouse0.94320471
98NANOG_16518401_ChIP-PET_MESCs_Mouse0.92473641
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92100923
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88241307

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat7.24196156
2MP0003941_abnormal_skin_development3.45366218
3MP0009672_abnormal_birth_weight3.13222322
4MP0003693_abnormal_embryo_hatching3.12060963
5MP0003111_abnormal_nucleus_morphology2.99200107
6MP0004957_abnormal_blastocyst_morpholog2.87920656
7MP0003890_abnormal_embryonic-extraembry2.52151967
8MP0010094_abnormal_chromosome_stability2.39986088
9MP0008877_abnormal_DNA_methylation2.39288375
10MP0008057_abnormal_DNA_replication2.39255014
11MP0008932_abnormal_embryonic_tissue2.32706161
12MP0001730_embryonic_growth_arrest2.31583718
13MP0001849_ear_inflammation2.20171625
14MP0010030_abnormal_orbit_morphology2.00752373
15MP0003119_abnormal_digestive_system2.00409308
16MP0010352_gastrointestinal_tract_polyps1.97407828
17MP0003077_abnormal_cell_cycle1.89899821
18MP0001672_abnormal_embryogenesis/_devel1.87809725
19MP0005380_embryogenesis_phenotype1.87809725
20MP0002085_abnormal_embryonic_tissue1.86847985
21MP0008058_abnormal_DNA_repair1.85413944
22MP0003567_abnormal_fetal_cardiomyocyte1.84569112
23MP0003718_maternal_effect1.83466169
24MP0002697_abnormal_eye_size1.80991245
25MP0003937_abnormal_limbs/digits/tail_de1.80266106
26MP0002084_abnormal_developmental_patter1.79903876
27MP0009703_decreased_birth_body1.76366673
28MP0005377_hearing/vestibular/ear_phenot1.75576036
29MP0003878_abnormal_ear_physiology1.75576036
30MP0009278_abnormal_bone_marrow1.74159716
31MP0004133_heterotaxia1.71457195
32MP0003984_embryonic_growth_retardation1.69800622
33MP0000537_abnormal_urethra_morphology1.64950440
34MP0003136_yellow_coat_color1.64395230
35MP0002088_abnormal_embryonic_growth/wei1.62570049
36MP0001293_anophthalmia1.58994547
37MP0000350_abnormal_cell_proliferation1.49852387
38MP0001299_abnormal_eye_distance/1.49116312
39MP0004197_abnormal_fetal_growth/weight/1.45149074
40MP0003705_abnormal_hypodermis_morpholog1.43314940
41MP0002080_prenatal_lethality1.42237420
42MP0000049_abnormal_middle_ear1.42168166
43MP0001697_abnormal_embryo_size1.38607345
44MP0003861_abnormal_nervous_system1.34527186
45MP0004272_abnormal_basement_membrane1.33892017
46MP0000428_abnormal_craniofacial_morphol1.28967884
47MP0004233_abnormal_muscle_weight1.27668420
48MP0000566_synostosis1.26722989
49MP0001286_abnormal_eye_development1.19392103
50MP0003566_abnormal_cell_adhesion1.19065866
51MP0000432_abnormal_head_morphology1.18796555
52MP0010307_abnormal_tumor_latency1.18254400
53MP0002111_abnormal_tail_morphology1.17010038
54MP0005076_abnormal_cell_differentiation1.13296863
55MP0005257_abnormal_intraocular_pressure1.12527904
56MP0002086_abnormal_extraembryonic_tissu1.12355027
57MP0004858_abnormal_nervous_system1.07517327
58MP0001915_intracranial_hemorrhage1.06080262
59MP0008007_abnormal_cellular_replicative1.05395670
60MP0003115_abnormal_respiratory_system1.05291650
61MP0006292_abnormal_olfactory_placode1.04434112
62MP0003935_abnormal_craniofacial_develop1.00056028
63MP0002089_abnormal_postnatal_growth/wei0.98867990
64MP0002796_impaired_skin_barrier0.97244152
65MP0003787_abnormal_imprinting0.97195248
66MP0002938_white_spotting0.95455270
67MP0000579_abnormal_nail_morphology0.95143017
68MP0002233_abnormal_nose_morphology0.94419003
69MP0005394_taste/olfaction_phenotype0.93352391
70MP0005499_abnormal_olfactory_system0.93352391
71MP0004264_abnormal_extraembryonic_tissu0.92556657
72MP0001188_hyperpigmentation0.91948685
73MP0000313_abnormal_cell_death0.91444367
74MP0001661_extended_life_span0.91326758
75MP0000678_abnormal_parathyroid_gland0.90876952
76MP0002396_abnormal_hematopoietic_system0.90721545
77MP0004859_abnormal_synaptic_plasticity0.90462436
78MP0003942_abnormal_urinary_system0.88592985
79MP0002925_abnormal_cardiovascular_devel0.86394948
80MP0003122_maternal_imprinting0.83300422
81MP0002751_abnormal_autonomic_nervous0.83055425
82MP0003121_genomic_imprinting0.82185841
83MP0002092_abnormal_eye_morphology0.81431187
84MP0002081_perinatal_lethality0.81361353
85MP0004270_analgesia0.81267068
86MP0003938_abnormal_ear_development0.81037453
87MP0010630_abnormal_cardiac_muscle0.79723288
88MP0002009_preneoplasia0.79088394
89MP0008770_decreased_survivor_rate0.74841119
90MP0004185_abnormal_adipocyte_glucose0.72797608
91MP0002116_abnormal_craniofacial_bone0.71604226
92MP0000003_abnormal_adipose_tissue0.67444951
93MP0005501_abnormal_skin_physiology0.67000607
94MP0003755_abnormal_palate_morphology0.65778591
95MP0002152_abnormal_brain_morphology0.64588231
96MP0003385_abnormal_body_wall0.64516816
97MP0004808_abnormal_hematopoietic_stem0.62086075
98MP0002090_abnormal_vision0.61744548
99MP0005621_abnormal_cell_physiology0.61557921
100MP0009384_cardiac_valve_regurgitation0.61237926

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)4.69796632
2Choanal stenosis (HP:0000452)3.95006131
3Spastic diplegia (HP:0001264)3.89630117
4Cortical dysplasia (HP:0002539)3.70826325
5Colon cancer (HP:0003003)3.53391071
6Abnormality of the labia minora (HP:0012880)3.38998165
7Nephroblastoma (Wilms tumor) (HP:0002667)3.31927613
8Embryonal renal neoplasm (HP:0011794)3.06116459
9Bronchomalacia (HP:0002780)3.03143377
10Selective tooth agenesis (HP:0001592)3.03098902
11Septo-optic dysplasia (HP:0100842)3.01046656
12Aplasia/Hypoplasia of the sternum (HP:0006714)2.96936751
13Bilateral microphthalmos (HP:0007633)2.93674247
14Turricephaly (HP:0000262)2.91114368
15Shallow orbits (HP:0000586)2.86631249
16Skull defect (HP:0001362)2.81580533
17Ependymoma (HP:0002888)2.72567685
18Neoplasm of the adrenal cortex (HP:0100641)2.68226826
19Broad thumb (HP:0011304)2.68045032
20Trigonocephaly (HP:0000243)2.67004493
21Broad metatarsal (HP:0001783)2.58424424
22Urethral obstruction (HP:0000796)2.50258215
23Increased nuchal translucency (HP:0010880)2.45641640
24Chronic bronchitis (HP:0004469)2.44106087
25Aqueductal stenosis (HP:0002410)2.42625736
26High anterior hairline (HP:0009890)2.41556593
27Malignant gastrointestinal tract tumors (HP:0006749)2.37596851
28Gastrointestinal carcinoma (HP:0002672)2.37596851
29Medulloblastoma (HP:0002885)2.32572628
30Myelomeningocele (HP:0002475)2.29533557
31Abnormal hair whorl (HP:0010721)2.27491155
32Abnormal lung lobation (HP:0002101)2.26657773
33Rhabdomyosarcoma (HP:0002859)2.23757461
34Generalized hypotonia (HP:0001290)2.23451013
35Arnold-Chiari malformation (HP:0002308)2.22172194
36Broad phalanges of the hand (HP:0009768)2.19361636
37Dysmetric saccades (HP:0000641)2.18713096
38Intestinal fistula (HP:0100819)2.17722068
39Cutaneous syndactyly (HP:0012725)2.17574732
40Maternal diabetes (HP:0009800)2.15119049
41Broad finger (HP:0001500)2.14570963
42Absent eyelashes (HP:0000561)2.12711517
43Hyperacusis (HP:0010780)2.09563989
44Embryonal neoplasm (HP:0002898)2.09141755
45Facial cleft (HP:0002006)2.08899516
46Impulsivity (HP:0100710)2.07545933
47Vaginal fistula (HP:0004320)2.06798829
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.06240161
49Rectal fistula (HP:0100590)2.03424372
50Rectovaginal fistula (HP:0000143)2.03424372
51Abnormality of homocysteine metabolism (HP:0010919)2.01158919
52Homocystinuria (HP:0002156)2.01158919
53Omphalocele (HP:0001539)2.01060103
54Overriding aorta (HP:0002623)2.01059562
55Carpal bone hypoplasia (HP:0001498)1.99326014
56Anal stenosis (HP:0002025)1.97697740
57Intestinal atresia (HP:0011100)1.97307567
58Humeroradial synostosis (HP:0003041)1.95748150
59Synostosis involving the elbow (HP:0003938)1.95748150
60Short hallux (HP:0010109)1.94826945
61Absent eyebrow (HP:0002223)1.94599135
62Multiple enchondromatosis (HP:0005701)1.92290758
63Hypotelorism (HP:0000601)1.91609361
64Broad long bones (HP:0005622)1.90655824
65Abnormality of the septum pellucidum (HP:0007375)1.90568092
66Aplasia/Hypoplasia of the hallux (HP:0008362)1.89778666
67Cutaneous finger syndactyly (HP:0010554)1.87875870
68Preauricular skin tag (HP:0000384)1.86964784
69Broad phalanx (HP:0006009)1.85887898
70Esophageal atresia (HP:0002032)1.85647839
71Absent radius (HP:0003974)1.85604838
72Birth length less than 3rd percentile (HP:0003561)1.85443365
73Aplasia involving bones of the upper limbs (HP:0009823)1.83186674
74Aplasia of the phalanges of the hand (HP:0009802)1.83186674
75Aplasia involving bones of the extremities (HP:0009825)1.83186674
76Hypoglycemic seizures (HP:0002173)1.82788810
77Neoplasm of striated muscle (HP:0009728)1.82045489
78Chromsome breakage (HP:0040012)1.80684540
79Lower limb amyotrophy (HP:0007210)1.79791684
80Bifid tongue (HP:0010297)1.79435200
81Pancreatic islet-cell hyperplasia (HP:0004510)1.79120119
82Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78484849
83Partial duplication of thumb phalanx (HP:0009944)1.78151709
84Long foot (HP:0001833)1.77845662
85Uterine leiomyosarcoma (HP:0002891)1.77844514
86Leiomyosarcoma (HP:0100243)1.77844514
87Abnormality of the lacrimal duct (HP:0011481)1.77477173
88Abnormality of the salivary glands (HP:0010286)1.75255208
89Duplication of thumb phalanx (HP:0009942)1.72933290
90Progressive external ophthalmoplegia (HP:0000590)1.72465513
91Abnormal number of incisors (HP:0011064)1.72169216
92Skin tags (HP:0010609)1.71617995
93Absent forearm bone (HP:0003953)1.69655341
94Aplasia involving forearm bones (HP:0009822)1.69655341
95Partial agenesis of the corpus callosum (HP:0001338)1.66356808
96Abnormality of abdominal situs (HP:0011620)1.65467200
97Abdominal situs inversus (HP:0003363)1.65467200
98Absent septum pellucidum (HP:0001331)1.65229536
99Primitive neuroectodermal tumor (HP:0030065)1.65173834
100Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.65173834

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.91493431
2EEF2K3.63071382
3SMG13.35853852
4TSSK63.00134061
5TTK2.97444039
6CDC72.89884520
7CDK122.87138284
8PASK2.57281752
9FGFR22.49167045
10MKNK12.35576592
11CAMK1D2.30237143
12TAF12.29633554
13CDK192.20618832
14VRK22.17407304
15CAMK1G2.08586795
16FGFR42.05804391
17SRPK11.98541884
18BUB11.63596493
19PLK31.57845284
20BRD41.56778491
21MAP3K91.55506260
22DYRK21.53939807
23FGFR11.51321931
24BMX1.49955844
25MKNK21.44785365
26TYRO31.40214564
27PDGFRA1.34746036
28NLK1.31489068
29ICK1.26680438
30ZAK1.25314063
31PLK41.23208583
32CDK71.17264213
33TNIK1.15489387
34STK38L1.14135387
35CHEK21.11355047
36TTN1.11328453
37LATS11.10706421
38KDR1.09709372
39LATS21.09699528
40CSNK1G11.09462851
41NTRK11.07423471
42ALK1.02209190
43ERBB41.01958997
44ATR1.00198552
45NEK21.00001869
46TIE10.94442468
47DYRK30.92721719
48CHEK10.92595959
49MTOR0.90655984
50PAK40.87901206
51PLK10.86063110
52CDK40.84812513
53STK30.84050206
54ATM0.83049037
55FLT30.81614593
56CDK20.78716875
57RPS6KB20.76307132
58CASK0.75905505
59NME10.69864936
60CDK10.69761478
61DYRK1A0.67211446
62PTK20.65443152
63PIM10.61666278
64RPS6KA10.60238124
65PRKDC0.59729081
66STK240.57654125
67FGR0.56943982
68MAP3K80.56194309
69EGFR0.53346674
70CDK60.52772459
71SGK4940.52673723
72SGK2230.52673723
73MAPK100.51528523
74DAPK10.50832573
75MAP3K40.50658900
76SGK30.50624546
77GSK3B0.50033808
78EIF2AK20.49365469
79MET0.46930408
80AURKB0.46533163
81CSNK1G30.46181002
82RPS6KA20.45711987
83MAPK90.45683821
84STK40.42122137
85CDK90.40938364
86CDK11A0.39682221
87CSNK1E0.39667758
88CLK10.39640346
89CSNK1A1L0.38894418
90CSNK1G20.38296905
91BRSK20.38099082
92VRK10.37601860
93MAP2K20.37431898
94MAPK140.37294344
95CDK150.37092427
96AKT10.36008394
97CDK180.35561795
98SGK20.35128871
99YES10.34859199
100BRSK10.34761877

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.40931523
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.91572887
3Mismatch repair_Homo sapiens_hsa034302.68141308
4Base excision repair_Homo sapiens_hsa034102.64061997
5Spliceosome_Homo sapiens_hsa030402.50766797
6mRNA surveillance pathway_Homo sapiens_hsa030152.49493212
7Non-homologous end-joining_Homo sapiens_hsa034502.38009366
8Biosynthesis of amino acids_Homo sapiens_hsa012302.37421390
9Adherens junction_Homo sapiens_hsa045202.36690139
10RNA transport_Homo sapiens_hsa030132.31671192
11Cell cycle_Homo sapiens_hsa041102.25520335
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.20024432
13Selenocompound metabolism_Homo sapiens_hsa004502.19615570
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.11453165
15Lysine degradation_Homo sapiens_hsa003102.10987159
16Cysteine and methionine metabolism_Homo sapiens_hsa002702.09689746
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.82383841
18One carbon pool by folate_Homo sapiens_hsa006701.79385323
19Thyroid cancer_Homo sapiens_hsa052161.74165157
20Basal cell carcinoma_Homo sapiens_hsa052171.66257974
21Tight junction_Homo sapiens_hsa045301.62114511
22MicroRNAs in cancer_Homo sapiens_hsa052061.58436366
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.55628648
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49140453
25Wnt signaling pathway_Homo sapiens_hsa043101.47966635
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.45036332
27Hippo signaling pathway_Homo sapiens_hsa043901.44190979
28Pentose phosphate pathway_Homo sapiens_hsa000301.39580291
29Colorectal cancer_Homo sapiens_hsa052101.36159590
30Basal transcription factors_Homo sapiens_hsa030221.28397903
31Carbon metabolism_Homo sapiens_hsa012001.26057544
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20703711
33Vitamin B6 metabolism_Homo sapiens_hsa007501.19712163
34Prostate cancer_Homo sapiens_hsa052151.19598592
35Nucleotide excision repair_Homo sapiens_hsa034201.13071023
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12360576
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11506234
38Notch signaling pathway_Homo sapiens_hsa043301.10452657
39Endometrial cancer_Homo sapiens_hsa052131.10137924
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.08852985
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07426233
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02988825
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02673423
44RNA polymerase_Homo sapiens_hsa030200.98777694
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97786906
46Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94901224
47Oocyte meiosis_Homo sapiens_hsa041140.94543820
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92212112
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91465899
50Fanconi anemia pathway_Homo sapiens_hsa034600.91330311
51RNA degradation_Homo sapiens_hsa030180.91074082
52Homologous recombination_Homo sapiens_hsa034400.85342629
53Hedgehog signaling pathway_Homo sapiens_hsa043400.77161602
54Melanogenesis_Homo sapiens_hsa049160.72621798
55p53 signaling pathway_Homo sapiens_hsa041150.70790144
56Axon guidance_Homo sapiens_hsa043600.69714080
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68309296
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67780363
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67636934
60Pyrimidine metabolism_Homo sapiens_hsa002400.65475629
61Purine metabolism_Homo sapiens_hsa002300.61414738
62Chronic myeloid leukemia_Homo sapiens_hsa052200.61103548
63Gap junction_Homo sapiens_hsa045400.60122576
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59876573
65Pyruvate metabolism_Homo sapiens_hsa006200.57456844
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57316984
67TGF-beta signaling pathway_Homo sapiens_hsa043500.57125848
68Bladder cancer_Homo sapiens_hsa052190.57114627
69Proteoglycans in cancer_Homo sapiens_hsa052050.56741063
70AMPK signaling pathway_Homo sapiens_hsa041520.55157809
71Insulin signaling pathway_Homo sapiens_hsa049100.54236077
72Pathways in cancer_Homo sapiens_hsa052000.54196767
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54182569
74Steroid biosynthesis_Homo sapiens_hsa001000.52108226
75Galactose metabolism_Homo sapiens_hsa000520.50816975
76Rap1 signaling pathway_Homo sapiens_hsa040150.50784711
77Glucagon signaling pathway_Homo sapiens_hsa049220.50727600
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49657097
79ErbB signaling pathway_Homo sapiens_hsa040120.46293645
80Arginine and proline metabolism_Homo sapiens_hsa003300.45618723
81Viral carcinogenesis_Homo sapiens_hsa052030.44478148
82Melanoma_Homo sapiens_hsa052180.43834498
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43660436
84Fatty acid elongation_Homo sapiens_hsa000620.42601612
85Long-term depression_Homo sapiens_hsa047300.42104345
86Fructose and mannose metabolism_Homo sapiens_hsa000510.39088553
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39026676
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.38543861
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37345809
90Thyroid hormone synthesis_Homo sapiens_hsa049180.35180740
91Nicotine addiction_Homo sapiens_hsa050330.32307464
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30945584
93Inositol phosphate metabolism_Homo sapiens_hsa005620.29559836
94Choline metabolism in cancer_Homo sapiens_hsa052310.29404335
95Acute myeloid leukemia_Homo sapiens_hsa052210.28017934
96Taste transduction_Homo sapiens_hsa047420.27093891
97Vitamin digestion and absorption_Homo sapiens_hsa049770.26435972
98Focal adhesion_Homo sapiens_hsa045100.25918477
99Estrogen signaling pathway_Homo sapiens_hsa049150.25619266
100Protein digestion and absorption_Homo sapiens_hsa049740.25372306

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