PHC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)4.79133464
2modulation by symbiont of host defense response (GO:0052031)4.79133464
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.79133464
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.79133464
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.79133464
6modulation by symbiont of host immune response (GO:0052553)4.79133464
7negative regulation of cell killing (GO:0031342)4.38101198
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.38101198
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.22807523
10response to peptidoglycan (GO:0032494)4.16307517
11detection of molecule of bacterial origin (GO:0032490)4.14827186
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.99611852
13macrophage activation involved in immune response (GO:0002281)3.96935591
14detection of other organism (GO:0098543)3.82990314
15protein localization to endosome (GO:0036010)3.74827458
16negative regulation of erythrocyte differentiation (GO:0045647)3.71840523
17antigen processing and presentation of endogenous antigen (GO:0019883)3.71705908
18detection of external biotic stimulus (GO:0098581)3.69151069
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.61094188
20detection of bacterium (GO:0016045)3.56592741
21neutrophil activation involved in immune response (GO:0002283)3.45231841
22stress fiber assembly (GO:0043149)3.44711428
23cytoskeletal anchoring at plasma membrane (GO:0007016)3.31424753
24leukocyte migration involved in inflammatory response (GO:0002523)3.30271243
25cellular extravasation (GO:0045123)3.27852134
26positive regulation of histone deacetylation (GO:0031065)3.27253757
27cortical actin cytoskeleton organization (GO:0030866)3.26224008
28detection of biotic stimulus (GO:0009595)3.23577293
29negative regulation of interleukin-12 production (GO:0032695)3.21208062
30negative regulation of fatty acid transport (GO:2000192)3.20608437
31positive regulation of gamma-delta T cell activation (GO:0046645)3.19289339
32positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.17430413
33response to host (GO:0075136)3.16226652
34response to host defenses (GO:0052200)3.16226652
35response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.16226652
36negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.15615322
37barbed-end actin filament capping (GO:0051016)3.13713625
38regulation of T-helper 2 cell differentiation (GO:0045628)3.13711028
39regulation of myeloid leukocyte mediated immunity (GO:0002886)3.13016344
40semaphorin-plexin signaling pathway (GO:0071526)3.10482056
41regulation of leukocyte degranulation (GO:0043300)3.10147789
42growth hormone receptor signaling pathway (GO:0060396)3.09245801
43response to host immune response (GO:0052572)3.07473064
44response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.07473064
45regulation of early endosome to late endosome transport (GO:2000641)3.03250565
46response to muramyl dipeptide (GO:0032495)3.00582611
47regulation of mast cell degranulation (GO:0043304)2.99481107
48leukocyte aggregation (GO:0070486)2.96836284
49endothelial tube morphogenesis (GO:0061154)2.96037793
50morphogenesis of an endothelium (GO:0003159)2.96037793
51regulation of hippo signaling (GO:0035330)2.90629779
52cytoplasmic mRNA processing body assembly (GO:0033962)2.89565128
53macrophage activation (GO:0042116)2.89249822
54regulation of interferon-beta biosynthetic process (GO:0045357)2.87087882
55cell adhesion mediated by integrin (GO:0033627)2.84860553
56positive regulation of cellular amide metabolic process (GO:0034250)2.84415999
57lipopolysaccharide-mediated signaling pathway (GO:0031663)2.78788154
58hippo signaling (GO:0035329)2.78097595
59cortical cytoskeleton organization (GO:0030865)2.74208699
60positive regulation of receptor recycling (GO:0001921)2.74011372
61regulation of macrophage cytokine production (GO:0010935)2.72624164
62intracellular estrogen receptor signaling pathway (GO:0030520)2.72178609
63adherens junction assembly (GO:0034333)2.71749867
64negative regulation of catenin import into nucleus (GO:0035414)2.70967854
65negative regulation of toll-like receptor signaling pathway (GO:0034122)2.70389885
66neutrophil activation (GO:0042119)2.69724574
67antigen processing and presentation via MHC class Ib (GO:0002475)2.69606191
68regulation of mast cell activation involved in immune response (GO:0033006)2.68557969
69germinal center formation (GO:0002467)2.68371460
70negative regulation of lymphocyte mediated immunity (GO:0002707)2.68289460
71corticosteroid receptor signaling pathway (GO:0031958)2.67149754
72platelet-derived growth factor receptor signaling pathway (GO:0048008)2.64595644
73cellular response to growth hormone stimulus (GO:0071378)2.63632204
74regulation of regulated secretory pathway (GO:1903305)2.62686089
75negative regulation of leukocyte mediated immunity (GO:0002704)2.62299212
76polarized epithelial cell differentiation (GO:0030859)2.61997893
77positive regulation of epithelial to mesenchymal transition (GO:0010718)2.61620525
78SMAD protein complex assembly (GO:0007183)2.60409146
79regulation of ARF GTPase activity (GO:0032312)2.60070251
80production of molecular mediator involved in inflammatory response (GO:0002532)2.60035472
81glucocorticoid receptor signaling pathway (GO:0042921)2.58836477
82embryonic foregut morphogenesis (GO:0048617)2.57332466
83hypotonic response (GO:0006971)2.56550342
84granulocyte activation (GO:0036230)2.55558896
85positive regulation of Cdc42 GTPase activity (GO:0043089)2.54206726
86respiratory burst (GO:0045730)2.51534253
87mannose metabolic process (GO:0006013)2.50945897
88negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.50882721
89regulation of extracellular matrix disassembly (GO:0010715)2.50405393
90peptidyl-lysine dimethylation (GO:0018027)2.47430725
91microglial cell activation (GO:0001774)2.47343109
92modulation by symbiont of host cellular process (GO:0044068)2.45959815
93negative regulation of cell size (GO:0045792)2.45189609
94positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.44249231
95mesodermal cell differentiation (GO:0048333)2.44208604
96regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43590933
97positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.42183809
98skin morphogenesis (GO:0043589)2.41773312
99response to interleukin-15 (GO:0070672)2.41092778
100positive regulation of extracellular matrix organization (GO:1903055)2.41041949
101regulation of necroptotic process (GO:0060544)2.40795795
102endodermal cell differentiation (GO:0035987)2.40788760
103lens fiber cell development (GO:0070307)2.39166357
104neutrophil mediated immunity (GO:0002446)2.39076435
105negative regulation of type 2 immune response (GO:0002829)2.38549167
106planar cell polarity pathway involved in neural tube closure (GO:0090179)2.38182218
107renal system development (GO:0072001)2.37908840
108positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.37466921
109negative regulation of cytokine production involved in immune response (GO:0002719)2.37277776
110glial cell proliferation (GO:0014009)2.35690900
111RNA stabilization (GO:0043489)2.34692969
112mRNA stabilization (GO:0048255)2.34692969
113positive regulation of blood vessel endothelial cell migration (GO:0043536)2.33417723
114myeloid cell activation involved in immune response (GO:0002275)2.33220786
115regulation of p38MAPK cascade (GO:1900744)2.32574790
116positive regulation of leukocyte degranulation (GO:0043302)2.31490765
117response to laminar fluid shear stress (GO:0034616)2.31121295
118cellular response to type I interferon (GO:0071357)2.30453825
119type I interferon signaling pathway (GO:0060337)2.30453825
120response to type I interferon (GO:0034340)2.30068794
121regulation of interleukin-12 biosynthetic process (GO:0045075)2.29986555
122positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.29834299
123establishment of epithelial cell polarity (GO:0090162)2.28929860
124regulation of gamma-delta T cell activation (GO:0046643)2.26424076
125regulation of amyloid precursor protein catabolic process (GO:1902991)2.26227676
126regulation of NFAT protein import into nucleus (GO:0051532)2.26015746
127positive regulation of macrophage cytokine production (GO:0060907)2.25939362
128cell-substrate junction assembly (GO:0007044)2.25800034
129modulation by virus of host process (GO:0019054)2.24419273
130apoptotic cell clearance (GO:0043277)2.23755808
131natural killer cell differentiation (GO:0001779)2.22942814
132positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.21502939
133immunoglobulin mediated immune response (GO:0016064)2.21274343
134plasma membrane repair (GO:0001778)2.20730910
135layer formation in cerebral cortex (GO:0021819)2.20132890
136pinocytosis (GO:0006907)2.20010876
137regulation of T cell tolerance induction (GO:0002664)2.19491559
138negative regulation of interleukin-6 production (GO:0032715)2.19374856
139positive regulation of mast cell activation (GO:0033005)2.19184800
140negative regulation of phagocytosis (GO:0050765)2.18944750
141positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.18859167
142regulation of superoxide anion generation (GO:0032928)2.18604003
143positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.18466271
144cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.18062827
145heterochromatin organization (GO:0070828)2.15344006
146signal complex assembly (GO:0007172)2.15214554
147establishment or maintenance of apical/basal cell polarity (GO:0035088)2.15093666
148establishment or maintenance of bipolar cell polarity (GO:0061245)2.15093666
149protein targeting to plasma membrane (GO:0072661)2.13727209
150positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.13017683
151positive regulation of protein deacetylation (GO:0090312)2.12840387
152response to nerve growth factor (GO:1990089)2.12766591
153cellular response to nerve growth factor stimulus (GO:1990090)2.12766591
154receptor catabolic process (GO:0032801)2.11617184
155response to fluid shear stress (GO:0034405)2.10456639
156paraxial mesoderm development (GO:0048339)2.10107747
157actin filament bundle assembly (GO:0051017)2.08918710
158actin filament bundle organization (GO:0061572)2.08918710
159regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.08798796
160regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.08315963
161protein heterotrimerization (GO:0070208)2.05056880
162vascular endothelial growth factor signaling pathway (GO:0038084)2.04932138
163establishment of endothelial barrier (GO:0061028)2.04816146
164collagen fibril organization (GO:0030199)2.04773641
165basement membrane organization (GO:0071711)2.04467910
1663-UTR-mediated mRNA stabilization (GO:0070935)2.02690080
167renal filtration (GO:0097205)2.02637866
168camera-type eye morphogenesis (GO:0048593)2.02433988
169establishment of nucleus localization (GO:0040023)2.02112158
170cell migration involved in sprouting angiogenesis (GO:0002042)2.01938167
171cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.01773671
172regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.01736311
173proximal/distal pattern formation (GO:0009954)2.01555413
174apoptotic process involved in morphogenesis (GO:0060561)2.01084000
175positive thymic T cell selection (GO:0045059)2.00717311
176epithelial cell differentiation involved in prostate gland development (GO:0060742)1.99977114
177activation of signaling protein activity involved in unfolded protein response (GO:0006987)1.99855600
178positive regulation of p38MAPK cascade (GO:1900745)1.99489876
179regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.99382813
180positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)1.99311059
181cytoskeleton-dependent cytokinesis (GO:0061640)1.99100254
182insulin-like growth factor receptor signaling pathway (GO:0048009)1.99018390
183ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043161.98689007
184cell-substrate adherens junction assembly (GO:0007045)1.97779889
185focal adhesion assembly (GO:0048041)1.97779889
186eye morphogenesis (GO:0048592)1.97472230
187myelin maintenance (GO:0043217)1.97413441
188positive regulation of Rap GTPase activity (GO:0032854)1.95876521
189axon extension involved in axon guidance (GO:0048846)1.95862370
190neuron projection extension involved in neuron projection guidance (GO:1902284)1.95862370
191endocytic recycling (GO:0032456)1.95460953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.93325969
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.14428041
3MYC_22102868_ChIP-Seq_BL_Human2.94332283
4* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.91383946
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.90398390
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.88001188
7* KDM2B_26808549_Chip-Seq_DND41_Human2.80605676
8* ELK3_25401928_ChIP-Seq_HUVEC_Human2.49543801
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.43964342
10* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.41323725
11* TCF7_22412390_ChIP-Seq_EML_Mouse2.36893668
12* KDM2B_26808549_Chip-Seq_K562_Human2.35207648
13* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.34673799
14WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.29332483
15VDR_21846776_ChIP-Seq_THP-1_Human2.28933830
16* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.28319201
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16607543
18* KDM2B_26808549_Chip-Seq_JURKAT_Human2.14903040
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12823459
20ZFP281_18757296_ChIP-ChIP_E14_Mouse2.09026673
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.08965109
22* P300_27058665_Chip-Seq_ZR-75-30cells_Human2.06876458
23* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01590309
24ZFP281_27345836_Chip-Seq_ESCs_Mouse2.00363247
25* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96055229
26LXR_22292898_ChIP-Seq_THP-1_Human1.93269442
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92206897
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.87721229
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.85918829
30DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.84000438
31* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.83750797
32* RACK7_27058665_Chip-Seq_MCF-7_Human1.82691617
33* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.81621868
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.81273687
35TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.78076388
36CLOCK_20551151_ChIP-Seq_293T_Human1.73413191
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.72545127
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69145557
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.66565031
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.65742921
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64762705
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62543784
43* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60442605
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.56688992
45* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.56680610
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55335473
47* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.54876669
48* MAF_26560356_Chip-Seq_TH1_Human1.53792089
49UTX_26944678_Chip-Seq_JUKART_Human1.53699969
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.53359412
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.51301650
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.51030516
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.50647274
54NFIB_24661679_ChIP-Seq_LUNG_Mouse1.50399879
55* VDR_24763502_ChIP-Seq_THP-1_Human1.50350367
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.49661336
57ATF3_27146783_Chip-Seq_COLON_Human1.48715788
58* CREB1_26743006_Chip-Seq_LNCaP_Human1.43872927
59TP53_22127205_ChIP-Seq_IMR90_Human1.42611150
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.41283556
61* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37557457
62* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34657050
63* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.33990974
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31665388
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31553090
66FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.31292266
67* UBF1/2_26484160_Chip-Seq_HMECs_Human1.28675336
68RUNX1_27514584_Chip-Seq_MCF-7_Human1.27434219
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.26461314
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25882196
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24658615
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24093509
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23668250
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22711523
75* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19582949
76* SPI1_23547873_ChIP-Seq_NB4_Human1.18680538
77* TBX20_22080862_ChIP-Seq_HEART_Mouse1.17458680
78* TBX20_22328084_ChIP-Seq_HEART_Mouse1.17458680
79FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16787745
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16766033
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15826569
82ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15436566
83* SPI1_23127762_ChIP-Seq_K562_Human1.15370921
84DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15357150
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.14755935
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14530878
87NCOR1_26117541_ChIP-Seq_K562_Human1.12903344
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12864694
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11773838
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11671345
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11568092
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10658793
93MAF_26560356_Chip-Seq_TH2_Human1.09390108
94TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08734864
95STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07512355
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06803594
97* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06516986
98VDR_24787735_ChIP-Seq_THP-1_Human1.06371204
99* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06150405
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05624267
101RXR_22158963_ChIP-Seq_LIVER_Mouse1.05548113
102MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05419372
103GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05241456
104SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05034732
105STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.04910490
106ISL1_27105846_Chip-Seq_CPCs_Mouse1.04627698
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04402438
108FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03245150
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02414483
110NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01937378
111SA1_27219007_Chip-Seq_ERYTHROID_Human1.00992112
112* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00626490
113* TET1_21451524_ChIP-Seq_MESCs_Mouse0.99682873
114FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99205719
115DROSHA_22980978_ChIP-Seq_HELA_Human0.98687769
116PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98530418
117ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97907462
118BCOR_27268052_Chip-Seq_Bcells_Human0.97655472
119HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96968709
120ZNF263_19887448_ChIP-Seq_K562_Human0.96794465
121* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96607601
122SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95339384
123* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95238960
124JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95206149
125SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94585547
126RUNX_20019798_ChIP-Seq_JUKART_Human0.94227796
127* TP53_23651856_ChIP-Seq_MEFs_Mouse0.93285891
128GATA1_19941826_ChIP-Seq_K562_Human0.93263123
129DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93186679
130P68_20966046_ChIP-Seq_HELA_Human0.92142539
131BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92011979
132SMC4_20622854_ChIP-Seq_HELA_Human0.91319238
133BRD4_25478319_ChIP-Seq_HGPS_Human0.91104308
134PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90950474
135CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89975340

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.21687091
2MP0003436_decreased_susceptibility_to3.68672529
3MP0003724_increased_susceptibility_to3.45123136
4MP0003191_abnormal_cellular_cholesterol3.15938128
5MP0003300_gastrointestinal_ulcer2.89730817
6MP0005076_abnormal_cell_differentiation2.66627826
7MP0003303_peritoneal_inflammation2.64326042
8MP0005623_abnormal_meninges_morphology2.57517845
9MP0005058_abnormal_lysosome_morphology2.41569512
10MP0003172_abnormal_lysosome_physiology2.41078513
11MP0002419_abnormal_innate_immunity2.37780181
12MP0009278_abnormal_bone_marrow2.34454693
13MP0008260_abnormal_autophagy2.32141186
14MP0008438_abnormal_cutaneous_collagen2.29488860
15MP0000537_abnormal_urethra_morphology2.28900584
16MP0000733_abnormal_muscle_development2.18779844
17MP0003828_pulmonary_edema2.13864672
18MP0001533_abnormal_skeleton_physiology2.13305061
19MP0003091_abnormal_cell_migration2.10522876
20MP0004510_myositis2.09880938
21MP0002877_abnormal_melanocyte_morpholog2.09452926
22MP0010352_gastrointestinal_tract_polyps2.05243298
23MP0001849_ear_inflammation2.00908229
24MP0009840_abnormal_foam_cell1.99963673
25MP0010030_abnormal_orbit_morphology1.98312556
26MP0001958_emphysema1.98042420
27MP0005025_abnormal_response_to1.92867692
28MP0002653_abnormal_ependyma_morphology1.92651548
29MP0003566_abnormal_cell_adhesion1.87695720
30MP0006082_CNS_inflammation1.81735820
31MP0010234_abnormal_vibrissa_follicle1.78122155
32MP0010368_abnormal_lymphatic_system1.75564499
33MP0003075_altered_response_to1.70577290
34MP0005464_abnormal_platelet_physiology1.70388032
35MP0003329_amyloid_beta_deposits1.70192055
36MP0005257_abnormal_intraocular_pressure1.70167907
37MP0003385_abnormal_body_wall1.65512669
38MP0003115_abnormal_respiratory_system1.61186190
39MP0009785_altered_susceptibility_to1.60288728
40MP0004272_abnormal_basement_membrane1.59653589
41MP0001835_abnormal_antigen_presentation1.58751013
42MP0005000_abnormal_immune_tolerance1.56083668
43MP0009053_abnormal_anal_canal1.56057928
44MP0003279_aneurysm1.54815321
45MP0005023_abnormal_wound_healing1.53181411
46MP0006054_spinal_hemorrhage1.52193721
47MP0005387_immune_system_phenotype1.49019379
48MP0001790_abnormal_immune_system1.49019379
49MP0000767_abnormal_smooth_muscle1.48496581
50MP0005409_darkened_coat_color1.47590397
51MP0004947_skin_inflammation1.46469848
52MP0005164_abnormal_response_to1.46461400
53MP0008961_abnormal_basal_metabolism1.44372818
54MP0000428_abnormal_craniofacial_morphol1.44133747
55MP0001879_abnormal_lymphatic_vessel1.43004147
56MP0004185_abnormal_adipocyte_glucose1.42526277
57MP0000604_amyloidosis1.39788369
58MP0003690_abnormal_glial_cell1.34717929
59MP0000343_altered_response_to1.32273358
60MP0000534_abnormal_ureter_morphology1.31725296
61MP0004858_abnormal_nervous_system1.31642636
62MP0002420_abnormal_adaptive_immunity1.30836023
63MP0002723_abnormal_immune_serum1.30806947
64MP0001819_abnormal_immune_cell1.29303241
65MP0004883_abnormal_blood_vessel1.29169435
66MP0003453_abnormal_keratinocyte_physiol1.28602663
67MP0002452_abnormal_antigen_presenting1.27041462
68MP0001348_abnormal_lacrimal_gland1.25652337
69MP0001915_intracranial_hemorrhage1.25564354
70MP0002405_respiratory_system_inflammati1.25317593
71MP0003935_abnormal_craniofacial_develop1.20895325
72MP0002925_abnormal_cardiovascular_devel1.20781721
73MP0001800_abnormal_humoral_immune1.20553494
74MP0002132_abnormal_respiratory_system1.20089068
75MP0001299_abnormal_eye_distance/1.17234376
76MP0003283_abnormal_digestive_organ1.15121960
77MP0003942_abnormal_urinary_system1.14781697
78MP0003755_abnormal_palate_morphology1.14429555
79MP0003448_altered_tumor_morphology1.12814026
80MP0003045_fibrosis1.12252620
81MP0002148_abnormal_hypersensitivity_rea1.12057567
82MP0005508_abnormal_skeleton_morphology1.11412596
83MP0005248_abnormal_Harderian_gland1.10669093
84MP0002234_abnormal_pharynx_morphology1.09409608
85* MP0002932_abnormal_joint_morphology1.08625229
86MP0004197_abnormal_fetal_growth/weight/1.04474183
87MP0002896_abnormal_bone_mineralization1.02986974
88MP0004808_abnormal_hematopoietic_stem1.02403184
89MP0001845_abnormal_inflammatory_respons1.01486563
90MP0009250_abnormal_appendicular_skeleto1.01475854
91MP0001730_embryonic_growth_arrest1.01268765
92MP0005166_decreased_susceptibility_to1.00358918
93MP0005503_abnormal_tendon_morphology1.00007143
94MP0010155_abnormal_intestine_physiology0.99481613
95MP0005275_abnormal_skin_tensile0.99294443
96MP0008469_abnormal_protein_level0.98613939
97MP0000685_abnormal_immune_system0.97470137
98MP0002084_abnormal_developmental_patter0.97212378
99MP0000858_altered_metastatic_potential0.96573169
100MP0000003_abnormal_adipose_tissue0.96352037
101MP0008004_abnormal_stomach_pH0.96295308
102MP0003183_abnormal_peptide_metabolism0.93939607
103MP0001614_abnormal_blood_vessel0.92964319
104MP0000920_abnormal_myelination0.92963126
105MP0002085_abnormal_embryonic_tissue0.92654505
106MP0003937_abnormal_limbs/digits/tail_de0.92234919
107MP0002282_abnormal_trachea_morphology0.92141993
108MP0002116_abnormal_craniofacial_bone0.91737683
109MP0001545_abnormal_hematopoietic_system0.91325491
110MP0005397_hematopoietic_system_phenotyp0.91325491
111MP0001851_eye_inflammation0.90812926
112MP0000750_abnormal_muscle_regeneration0.90782921
113MP0009764_decreased_sensitivity_to0.88647591
114MP0003119_abnormal_digestive_system0.88007098
115MP0000716_abnormal_immune_system0.86853195
116* MP0000350_abnormal_cell_proliferation0.86473678
117MP0000432_abnormal_head_morphology0.86030893
118MP0000249_abnormal_blood_vessel0.85193275
119MP0003795_abnormal_bone_structure0.84909592
120MP0010307_abnormal_tumor_latency0.82962996
121MP0005187_abnormal_penis_morphology0.82740307
122MP0001784_abnormal_fluid_regulation0.82729154
123MP0002933_joint_inflammation0.82656240
124MP0000751_myopathy0.82270298
125MP0000465_gastrointestinal_hemorrhage0.81733626
126MP0002998_abnormal_bone_remodeling0.81477564
127MP0003866_abnormal_defecation0.81470513
128MP0003634_abnormal_glial_cell0.80118515
129MP0002089_abnormal_postnatal_growth/wei0.79798436
130MP0002128_abnormal_blood_circulation0.79758055
131MP0010630_abnormal_cardiac_muscle0.78860914
132MP0003984_embryonic_growth_retardation0.78696941
133MP0010678_abnormal_skin_adnexa0.78097482
134MP0001697_abnormal_embryo_size0.77456004
135MP0003861_abnormal_nervous_system0.77352538
136MP0002088_abnormal_embryonic_growth/wei0.76813120
137MP0001340_abnormal_eyelid_morphology0.76540126
138MP0002086_abnormal_extraembryonic_tissu0.76435030
139MP0009333_abnormal_splenocyte_physiolog0.75893159
140MP0002398_abnormal_bone_marrow0.75827773
141MP0005451_abnormal_body_composition0.75614602
142MP0002092_abnormal_eye_morphology0.75475495
143MP0005380_embryogenesis_phenotype0.75319988
144MP0001672_abnormal_embryogenesis/_devel0.75319988
145MP0008007_abnormal_cellular_replicative0.75047583
146MP0002113_abnormal_skeleton_development0.74869042
147MP0001175_abnormal_lung_morphology0.74529702
148MP0004381_abnormal_hair_follicle0.74491384
149MP0008874_decreased_physiological_sensi0.73616921
150MP0005375_adipose_tissue_phenotype0.72327270
151MP0000747_muscle_weakness0.72313295
152MP0005390_skeleton_phenotype0.69950147
153MP0000266_abnormal_heart_morphology0.69764221
154MP0004087_abnormal_muscle_fiber0.69498001
155MP0002429_abnormal_blood_cell0.68120958
156MP0005621_abnormal_cell_physiology0.68095396
157MP0000678_abnormal_parathyroid_gland0.67871975
158MP0005666_abnormal_adipose_tissue0.67566582
159MP0002396_abnormal_hematopoietic_system0.67177128
160MP0000049_abnormal_middle_ear0.67169668
161MP0003879_abnormal_hair_cell0.66560387

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.33117189
2Shallow orbits (HP:0000586)3.98661410
3Cerebral aneurysm (HP:0004944)3.67948859
4Abnormality of macrophages (HP:0004311)3.63231740
5Peritonitis (HP:0002586)3.49659987
6Myositis (HP:0100614)3.48738267
7Protrusio acetabuli (HP:0003179)3.48354957
8Orchitis (HP:0100796)3.43621090
9Recurrent gram-negative bacterial infections (HP:0005420)3.38072528
10Recurrent abscess formation (HP:0002722)3.36255814
11Premature rupture of membranes (HP:0001788)3.30071714
12Hyperacusis (HP:0010780)3.08577422
13Recurrent bacterial skin infections (HP:0005406)3.05933392
14Bladder diverticulum (HP:0000015)3.01673515
15Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.95764550
16Short 4th metacarpal (HP:0010044)2.95764550
17Amyloidosis (HP:0011034)2.89593702
18Vascular tortuosity (HP:0004948)2.76506504
19Ulnar bowing (HP:0003031)2.72024160
20Aortic aneurysm (HP:0004942)2.68056630
21Gingivitis (HP:0000230)2.66650739
22Optic neuritis (HP:0100653)2.66346846
23Retrobulbar optic neuritis (HP:0100654)2.66346846
24Vertebral compression fractures (HP:0002953)2.65975512
25Arterial tortuosity (HP:0005116)2.62745398
26Mitral valve prolapse (HP:0001634)2.59744011
27Renal duplication (HP:0000075)2.55065603
28Spontaneous hematomas (HP:0007420)2.52450681
29Increased variability in muscle fiber diameter (HP:0003557)2.52147188
30Gastrointestinal infarctions (HP:0005244)2.50234883
31Aortic dissection (HP:0002647)2.50058149
32Increased IgE level (HP:0003212)2.47820238
33Overriding aorta (HP:0002623)2.47626294
34Obstructive sleep apnea (HP:0002870)2.47046818
35Genu recurvatum (HP:0002816)2.46324883
36Deep venous thrombosis (HP:0002625)2.44314001
37Chronic obstructive pulmonary disease (HP:0006510)2.41928657
38Obstructive lung disease (HP:0006536)2.41928657
39Abnormality of the 4th metacarpal (HP:0010012)2.41649972
40Dilatation of the ascending aorta (HP:0005111)2.38870718
41Deviation of the hallux (HP:0010051)2.37200810
42Hallux valgus (HP:0001822)2.32651564
43Mediastinal lymphadenopathy (HP:0100721)2.31626080
44Neurofibrillary tangles (HP:0002185)2.30551650
45Atrophic scars (HP:0001075)2.26808143
46Aneurysm (HP:0002617)2.25611635
47Upper limb amyotrophy (HP:0009129)2.25024222
48Distal upper limb amyotrophy (HP:0007149)2.25024222
49Increased density of long bones (HP:0006392)2.23761094
50Systemic lupus erythematosus (HP:0002725)2.21957724
51Abnormality of skeletal muscle fiber size (HP:0012084)2.21179832
52Broad metatarsal (HP:0001783)2.20027928
53Camptodactyly of toe (HP:0001836)2.17309145
54Bowel diverticulosis (HP:0005222)2.15917914
55Abnormality of glycolipid metabolism (HP:0010969)2.14471411
56Abnormality of liposaccharide metabolism (HP:0010968)2.14471411
57Abnormality of glycosphingolipid metabolism (HP:0004343)2.14471411
58Scapular winging (HP:0003691)2.13777742
59Abnormality of the peritoneum (HP:0002585)2.13653210
60Distal lower limb amyotrophy (HP:0008944)2.12455748
61Insomnia (HP:0100785)2.12144295
62Disproportionate tall stature (HP:0001519)2.11631678
63Hemorrhage of the eye (HP:0011885)2.11561490
64Loss of speech (HP:0002371)2.09773281
65Dysostosis multiplex (HP:0000943)2.09753751
66Segmental peripheral demyelination/remyelination (HP:0003481)2.09719304
67Insidious onset (HP:0003587)2.08846255
68Termporal pattern (HP:0011008)2.08846255
69Rectal prolapse (HP:0002035)2.08535775
70Subacute progressive viral hepatitis (HP:0006572)2.07786240
71Purpura (HP:0000979)2.06538013
72Metaphyseal cupping (HP:0003021)2.06105629
73Episodic fever (HP:0001954)2.05548249
74Asymmetry of the thorax (HP:0001555)2.05499724
75Elfin facies (HP:0004428)2.04161057
76Supranuclear gaze palsy (HP:0000605)2.03665952
77Trigonocephaly (HP:0000243)2.03426057
78Broad face (HP:0000283)2.02969248
79Pointed chin (HP:0000307)2.02910477
80Thin bony cortex (HP:0002753)2.02551616
81Hypochromic microcytic anemia (HP:0004840)2.01425304
82Arnold-Chiari malformation (HP:0002308)1.99861198
83Bronchomalacia (HP:0002780)1.99243477
84Persistence of primary teeth (HP:0006335)1.98397350
85Gingival bleeding (HP:0000225)1.97298829
86Axonal loss (HP:0003447)1.94733932
87Abnormality of complement system (HP:0005339)1.93945424
88Cerebral inclusion bodies (HP:0100314)1.93812338
89Urticaria (HP:0001025)1.91116801
90Ankle contracture (HP:0006466)1.90915398
91Stomatitis (HP:0010280)1.90774539
92Distal lower limb muscle weakness (HP:0009053)1.89908592
93Difficulty running (HP:0009046)1.89905926
94Prolonged bleeding time (HP:0003010)1.89026127
95Buphthalmos (HP:0000557)1.88993166
96Vertebral arch anomaly (HP:0008438)1.88981392
97Recurrent skin infections (HP:0001581)1.87887884
98Broad thumb (HP:0011304)1.87543600
99Renovascular hypertension (HP:0100817)1.87336364
100Enlarged penis (HP:0000040)1.86248725
101Milia (HP:0001056)1.85564138
102Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85264171
103Abnormality of polysaccharide metabolism (HP:0011012)1.85264171
104Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85264171
105Difficulty climbing stairs (HP:0003551)1.84997134
106Flat cornea (HP:0007720)1.84128224
107Hematochezia (HP:0002573)1.84087806
108Fragile skin (HP:0001030)1.84030322
109Chest pain (HP:0100749)1.83923664
110Keratoconjunctivitis sicca (HP:0001097)1.83746379
111Mucopolysacchariduria (HP:0008155)1.82888840
112Urinary glycosaminoglycan excretion (HP:0003541)1.82888840
113Meningitis (HP:0001287)1.82652813
114Pathologic fracture (HP:0002756)1.82491580
115Increased cerebral lipofuscin (HP:0011813)1.81290721
116Asymmetric septal hypertrophy (HP:0001670)1.81166554
117Exostoses (HP:0100777)1.80286410
118Striae distensae (HP:0001065)1.79648423
119Hypochromic anemia (HP:0001931)1.79475685
120Abnormality of oral frenula (HP:0000190)1.78715890
121Ankyloglossia (HP:0010296)1.78281831
122Epistaxis (HP:0000421)1.77800189
123Blue sclerae (HP:0000592)1.76723240
124Bowing of the arm (HP:0006488)1.76695434
125Bowed forearm bones (HP:0003956)1.76695434
126Mitral regurgitation (HP:0001653)1.76228419
127Macroorchidism (HP:0000053)1.75458140
128Turricephaly (HP:0000262)1.74389860
129Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.73545777
130Wormian bones (HP:0002645)1.73276215
131Recurrent fungal infections (HP:0002841)1.73125507
132Interstitial pulmonary disease (HP:0006530)1.72613111
133Centrally nucleated skeletal muscle fibers (HP:0003687)1.72537948
134Myocardial infarction (HP:0001658)1.71725377
135Cellulitis (HP:0100658)1.71530846
136Achilles tendon contracture (HP:0001771)1.71193595
137Muscle fiber splitting (HP:0003555)1.71011036
138Polycythemia (HP:0001901)1.70806857
139Onion bulb formation (HP:0003383)1.70102515
140Nuclear cataract (HP:0100018)1.69991786
141Spinal rigidity (HP:0003306)1.68615250
142Abnormality of the distal phalanx of the thumb (HP:0009617)1.68198379
143Back pain (HP:0003418)1.67815058
144Hand muscle atrophy (HP:0009130)1.66969959
145Abnormality of the fingertips (HP:0001211)1.66679517
146Lymphangioma (HP:0100764)1.66415198
147Arachnodactyly (HP:0001166)1.65308445
148Long toe (HP:0010511)1.65304562
149Fatigue (HP:0012378)1.65260226
150Joint contractures involving the joints of the feet (HP:0100492)1.65179547
151Flexion contracture of toe (HP:0005830)1.65179547
152Hyperextensible skin (HP:0000974)1.63964753
153Coronal craniosynostosis (HP:0004440)1.61215641
154Cervical subluxation (HP:0003308)1.59597714
155Increased nuchal translucency (HP:0010880)1.59551145
156Increased connective tissue (HP:0009025)1.58312262
157Male infertility (HP:0003251)1.57830796
158Hypercortisolism (HP:0001578)1.57594307
159Spondylolisthesis (HP:0003302)1.57347380
160Limited elbow extension (HP:0001377)1.56458943
161Abnormality of the calcaneus (HP:0008364)1.56296561
162Bladder neoplasm (HP:0009725)1.55209813
163Bladder carcinoma (HP:0002862)1.55209813
164Transitional cell carcinoma of the bladder (HP:0006740)1.54537167
165Broad phalanges of the hand (HP:0009768)1.54069029
166Overgrowth (HP:0001548)1.53778278
167Elevated erythrocyte sedimentation rate (HP:0003565)1.51941327
168Congenital glaucoma (HP:0001087)1.51833225
169Osteolytic defects of the hand bones (HP:0009699)1.50674445
170Osteolytic defects of the phalanges of the hand (HP:0009771)1.50674445
171Leiomyosarcoma (HP:0100243)1.50461039

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.68654690
2MAP3K103.88878836
3MAP2K32.82351771
4LATS22.67207695
5PKN22.60412705
6PRPF4B2.50968979
7LATS12.49296335
8RIPK42.42958721
9ERN12.28455447
10EEF2K2.27891243
11EPHB12.22902749
12PRKD32.19411023
13TAOK12.17986444
14PTK62.15694191
15IRAK42.01878068
16MAP3K31.97920539
17EPHB21.95435508
18BMX1.82664330
19TYK21.80514007
20PDGFRA1.75568292
21ZAP701.71931204
22ICK1.68950045
23IRAK31.67126737
24BLK1.62664218
25TTN1.61828565
26CDK121.60110789
27KSR21.58606249
28TYRO31.58293660
29MAP3K61.52058184
30RIPK11.49468788
31DDR21.49053841
32RPS6KA41.48806474
33SMG11.48140406
34LRRK21.44973113
35DMPK1.29567482
36PAK61.29042882
37FES1.27568718
38MAP4K11.27478924
39PDGFRB1.26829505
40TNK21.26757335
41MAP3K131.26236003
42PRKCH1.22052286
43PRKD21.21941471
44ALK1.21502946
45PTK21.20002700
46SIK31.18931543
47TAOK21.16181546
48MOS1.15667183
49SIK11.10845813
50STK101.10226407
51PDPK11.09661317
52PAK41.09131340
53RET1.05688876
54CDK61.03691125
55HIPK21.01287832
56MTOR1.00723589
57FGR0.99305903
58PAK20.98733101
59KSR10.97637128
60ILK0.94787203
61STK30.89599753
62SIK20.87990046
63GRK60.86825184
64EPHA30.86194033
65CDK40.85388085
66IRAK20.83822496
67FGFR40.82674564
68MAP2K20.81036778
69LMTK20.80471669
70CDK90.79310014
71PRKD10.78555456
72PDK10.77787432
73CAMK1G0.77203291
74CLK10.76412429
75JAK20.74145101
76BTK0.72755447
77ARAF0.72421847
78SGK30.71502833
79NEK20.69759367
80MAP3K80.69070996
81DYRK1B0.67408148
82RPS6KA20.65802056
83TBK10.65559423
84MARK20.63603112
85ROCK20.63430722
86MAP3K70.62866075
87PRKG20.62648891
88NTRK10.61845572
89TESK20.61461086
90CAMKK10.61255849
91RPS6KL10.60961922
92RPS6KC10.60961922
93MST1R0.60944364
94YES10.59473376
95MAP3K140.58873829
96FGFR20.58477690
97LIMK10.58063535
98STK110.57672369
99CHUK0.56987578
100CSF1R0.56708578
101ERBB20.56287789
102MAP2K40.55884946
103MAP3K90.55767713
104MAPK120.55582636
105MAP3K10.53572207
106PAK30.52318585
107MELK0.52232636
108HCK0.51821763
109STK380.51259106
110TESK10.51217907
111MAP3K20.51061083
112MAP3K110.50637114
113MET0.50404386
114TGFBR20.49589545
115FYN0.49493838
116IRAK10.48586772
117UHMK10.48538303
118CSNK1A1L0.47389997
119MAPK70.47153965
120GSK3A0.45586541
121SYK0.45426089
122CSK0.44404080
123JAK10.44364964
124KIT0.43894673
125FGFR30.43358425
126LCK0.43022883
127LYN0.42816386
128SCYL20.41641904
129CDK150.40813843
130CAMK1D0.40624131
131FER0.39491182
132CDK180.38099800
133MAP2K10.37881893
134PTK2B0.37382983
135WNK10.36827691
136ABL10.36707819
137CDK11A0.36609803
138CDK140.35802047
139CDC42BPA0.34973931
140FGFR10.34734304
141MARK30.34155097
142JAK30.33880199
143STK38L0.33814326
144EPHA20.33081622

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052202.17864635
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.14500768
3Other glycan degradation_Homo sapiens_hsa005111.93731360
4Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.85864616
5Pancreatic cancer_Homo sapiens_hsa052121.82436953
6Staphylococcus aureus infection_Homo sapiens_hsa051501.80413162
7Renal cell carcinoma_Homo sapiens_hsa052111.64008414
8Small cell lung cancer_Homo sapiens_hsa052221.60224522
9Adherens junction_Homo sapiens_hsa045201.58089022
10Proteoglycans in cancer_Homo sapiens_hsa052051.56913895
11Focal adhesion_Homo sapiens_hsa045101.56879283
12Bladder cancer_Homo sapiens_hsa052191.56310684
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.53678434
14MicroRNAs in cancer_Homo sapiens_hsa052061.51968915
15Endometrial cancer_Homo sapiens_hsa052131.49774775
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48974306
17Dorso-ventral axis formation_Homo sapiens_hsa043201.48314841
18Non-small cell lung cancer_Homo sapiens_hsa052231.46976725
19VEGF signaling pathway_Homo sapiens_hsa043701.46071540
20Hippo signaling pathway_Homo sapiens_hsa043901.46026292
21Notch signaling pathway_Homo sapiens_hsa043301.45664622
22Colorectal cancer_Homo sapiens_hsa052101.45255830
23Glioma_Homo sapiens_hsa052141.45137833
24B cell receptor signaling pathway_Homo sapiens_hsa046621.40579042
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.37480082
26ECM-receptor interaction_Homo sapiens_hsa045121.37427280
27Neurotrophin signaling pathway_Homo sapiens_hsa047221.35296202
28Viral myocarditis_Homo sapiens_hsa054161.34821111
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.25981739
30Shigellosis_Homo sapiens_hsa051311.25280410
31Prolactin signaling pathway_Homo sapiens_hsa049171.23067527
32Toxoplasmosis_Homo sapiens_hsa051451.22041282
33Prion diseases_Homo sapiens_hsa050201.21859938
34Phagosome_Homo sapiens_hsa041451.21307621
35Axon guidance_Homo sapiens_hsa043601.21241599
36Basal cell carcinoma_Homo sapiens_hsa052171.19288827
37Osteoclast differentiation_Homo sapiens_hsa043801.18575581
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17734217
39Estrogen signaling pathway_Homo sapiens_hsa049151.15078242
40Acute myeloid leukemia_Homo sapiens_hsa052211.13407215
41Amoebiasis_Homo sapiens_hsa051461.13299678
42Regulation of actin cytoskeleton_Homo sapiens_hsa048101.13088151
43mTOR signaling pathway_Homo sapiens_hsa041501.12967481
44TGF-beta signaling pathway_Homo sapiens_hsa043501.10097985
45Prostate cancer_Homo sapiens_hsa052151.08963749
46Lysosome_Homo sapiens_hsa041421.08088358
47Hedgehog signaling pathway_Homo sapiens_hsa043401.07353187
48TNF signaling pathway_Homo sapiens_hsa046681.06277232
49Hepatitis B_Homo sapiens_hsa051611.06237532
50Leishmaniasis_Homo sapiens_hsa051401.05992994
51Phospholipase D signaling pathway_Homo sapiens_hsa040721.05674708
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04574574
53ErbB signaling pathway_Homo sapiens_hsa040121.03150292
54Chemokine signaling pathway_Homo sapiens_hsa040621.02800502
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02778733
56Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02733743
57Endocytosis_Homo sapiens_hsa041441.01906654
58Platelet activation_Homo sapiens_hsa046111.01071180
59Thyroid cancer_Homo sapiens_hsa052161.00565429
60T cell receptor signaling pathway_Homo sapiens_hsa046601.00430564
61Rap1 signaling pathway_Homo sapiens_hsa040151.00426547
62Tight junction_Homo sapiens_hsa045300.97663284
63HTLV-I infection_Homo sapiens_hsa051660.96992602
64Influenza A_Homo sapiens_hsa051640.96621335
65Complement and coagulation cascades_Homo sapiens_hsa046100.96449017
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96319173
67Hepatitis C_Homo sapiens_hsa051600.95418540
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92682621
69Pathways in cancer_Homo sapiens_hsa052000.92506193
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92194992
71MAPK signaling pathway_Homo sapiens_hsa040100.89733203
72African trypanosomiasis_Homo sapiens_hsa051430.88687714
73Salmonella infection_Homo sapiens_hsa051320.88629875
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88572551
75GnRH signaling pathway_Homo sapiens_hsa049120.88481428
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.88457462
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87608031
78Apoptosis_Homo sapiens_hsa042100.87149264
79Gap junction_Homo sapiens_hsa045400.85612103
80Dilated cardiomyopathy_Homo sapiens_hsa054140.84838879
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83719312
82Melanogenesis_Homo sapiens_hsa049160.83705685
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81572809
84Insulin signaling pathway_Homo sapiens_hsa049100.81478673
85Legionellosis_Homo sapiens_hsa051340.79987888
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78800041
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78711535
88Wnt signaling pathway_Homo sapiens_hsa043100.77829061
89Choline metabolism in cancer_Homo sapiens_hsa052310.77292910
90FoxO signaling pathway_Homo sapiens_hsa040680.76509705
91HIF-1 signaling pathway_Homo sapiens_hsa040660.74412969
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73914116
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.73861839
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72797440
95Viral carcinogenesis_Homo sapiens_hsa052030.72083229
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71855373
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70514115
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70061038
99Melanoma_Homo sapiens_hsa052180.69885500
100Ras signaling pathway_Homo sapiens_hsa040140.69748953
101Measles_Homo sapiens_hsa051620.68846562
102Insulin resistance_Homo sapiens_hsa049310.66767675
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66491854
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.66394401
105Malaria_Homo sapiens_hsa051440.66005297
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65478450
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65443128
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65383426
109Cocaine addiction_Homo sapiens_hsa050300.65315309
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.65151660
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65039006
112Vibrio cholerae infection_Homo sapiens_hsa051100.64845006
113Tuberculosis_Homo sapiens_hsa051520.64327379
114Type II diabetes mellitus_Homo sapiens_hsa049300.64281523
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63573164
116Inositol phosphate metabolism_Homo sapiens_hsa005620.63543214
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63513614
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63405874
119Hematopoietic cell lineage_Homo sapiens_hsa046400.62362774
120Pertussis_Homo sapiens_hsa051330.60323409
121Cholinergic synapse_Homo sapiens_hsa047250.60310679
122Long-term potentiation_Homo sapiens_hsa047200.59997929
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.59952551
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58391024
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57551588
126Herpes simplex infection_Homo sapiens_hsa051680.54316309

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