PHEX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein is thought to be involved in bone and dentin mineralization and renal phosphate reabsorption. Mutations in this gene cause X-linked hypophosphatemic rickets. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)8.27555283
2regulation of DNA methylation (GO:0044030)7.80662560
3oocyte development (GO:0048599)7.67653072
4piRNA metabolic process (GO:0034587)7.34947530
5keratan sulfate catabolic process (GO:0042340)7.13046725
6regulation of acrosome reaction (GO:0060046)6.69287151
7response to parathyroid hormone (GO:0071107)6.60628389
8regulation of meiosis I (GO:0060631)6.49583377
9meiotic cell cycle (GO:0051321)6.27853263
10multicellular organism reproduction (GO:0032504)6.07606915
11retinal cone cell development (GO:0046549)5.58754107
12DNA methylation involved in gamete generation (GO:0043046)5.32822260
13regulation of gonadotropin secretion (GO:0032276)5.26721173
14chondrocyte proliferation (GO:0035988)5.03951087
15keratan sulfate biosynthetic process (GO:0018146)5.01359199
16female gamete generation (GO:0007292)5.00362725
17phosphate ion homeostasis (GO:0055062)4.84810935
18trivalent inorganic anion homeostasis (GO:0072506)4.84810935
19presynaptic membrane assembly (GO:0097105)4.73555044
20regulation of cell maturation (GO:1903429)4.72226846
21negative regulation of reproductive process (GO:2000242)4.54581138
22limb bud formation (GO:0060174)4.51432931
23keratan sulfate metabolic process (GO:0042339)4.42351205
24regulation of histone H3-K9 methylation (GO:0051570)4.34214401
25presynaptic membrane organization (GO:0097090)4.27618147
26regulation of steroid hormone secretion (GO:2000831)4.20291175
27gene silencing by RNA (GO:0031047)4.19673781
28positive regulation of histone H3-K4 methylation (GO:0051571)4.10887640
29positive regulation of reproductive process (GO:2000243)3.99083697
30mesenchymal cell differentiation involved in kidney development (GO:0072161)3.88968142
31mesenchymal cell differentiation involved in renal system development (GO:2001012)3.88968142
32regulation of steroid hormone biosynthetic process (GO:0090030)3.88765220
33reproduction (GO:0000003)3.86607823
34neuron cell-cell adhesion (GO:0007158)3.74267805
35regulation of transforming growth factor beta2 production (GO:0032909)3.69392387
36smooth muscle tissue development (GO:0048745)3.62653819
37centriole replication (GO:0007099)3.61447175
38postsynaptic membrane organization (GO:0001941)3.58815956
39regulation of endocrine process (GO:0044060)3.57998092
40negative regulation of hormone biosynthetic process (GO:0032353)3.55293980
41glycine transport (GO:0015816)3.51983558
42positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.51133260
43positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.51133260
44positive regulation of mitotic sister chromatid separation (GO:1901970)3.51133260
45keratinocyte development (GO:0003334)3.48257934
46tachykinin receptor signaling pathway (GO:0007217)3.47682529
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.45861305
48superoxide anion generation (GO:0042554)3.43399837
49negative regulation of histone methylation (GO:0031061)3.38684119
50endochondral ossification (GO:0001958)3.36359175
51replacement ossification (GO:0036075)3.36359175
52regulation of timing of cell differentiation (GO:0048505)3.35576043
53facial nerve structural organization (GO:0021612)3.35433070
54interkinetic nuclear migration (GO:0022027)3.35016254
55righting reflex (GO:0060013)3.34778771
56negative regulation of hormone metabolic process (GO:0032351)3.33964688
57positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.31362866
58import into cell (GO:0098657)3.30209794
59cranial nerve structural organization (GO:0021604)3.29302004
60axon ensheathment in central nervous system (GO:0032291)3.26531743
61central nervous system myelination (GO:0022010)3.26531743
62negative regulation of T cell differentiation in thymus (GO:0033085)3.23051527
63G-protein coupled receptor internalization (GO:0002031)3.18444922
64cerebral cortex radially oriented cell migration (GO:0021799)3.17511832
65negative regulation of bone mineralization (GO:0030502)3.13526672
66cranial nerve morphogenesis (GO:0021602)3.13209528
67fertilization (GO:0009566)3.12400922
68* biomineral tissue development (GO:0031214)3.06737438
69positive regulation of digestive system process (GO:0060456)3.05666736
70single fertilization (GO:0007338)3.04012899
71male meiosis (GO:0007140)3.02422834
72positive regulation of gastrulation (GO:2000543)3.02303000
73regulation of reproductive process (GO:2000241)3.02165786
74protein kinase C signaling (GO:0070528)3.00854924
75positive regulation of action potential (GO:0045760)2.98321997
76positive regulation of humoral immune response (GO:0002922)2.97527031
77epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.95838825
78synapsis (GO:0007129)2.94729044
79labyrinthine layer development (GO:0060711)2.92357647
80negative regulation of alpha-beta T cell differentiation (GO:0046639)2.91293924
81regulation of meiosis (GO:0040020)2.91185639
82thrombin receptor signaling pathway (GO:0070493)2.88437450
83regulation of non-canonical Wnt signaling pathway (GO:2000050)2.85043025
84cartilage condensation (GO:0001502)2.84410408
85cell aggregation (GO:0098743)2.84410408
86positive regulation of synapse assembly (GO:0051965)2.83900438
87primitive streak formation (GO:0090009)2.83620169
88regulation of development, heterochronic (GO:0040034)2.83238126
89sympathetic nervous system development (GO:0048485)2.83103945
90regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.81670701
91endoderm development (GO:0007492)2.81484589
92bone resorption (GO:0045453)2.81433962
93retina layer formation (GO:0010842)2.81189282
94attachment of spindle microtubules to kinetochore (GO:0008608)2.80706468
95positive regulation of chondrocyte differentiation (GO:0032332)2.80434651
96negative regulation of biomineral tissue development (GO:0070168)2.79015133
97mesenchymal cell differentiation (GO:0048762)2.75149094
98positive regulation of epidermal cell differentiation (GO:0045606)2.74971952
99lateral sprouting from an epithelium (GO:0060601)2.74824681
100activin receptor signaling pathway (GO:0032924)2.74281795
101startle response (GO:0001964)2.73788727
102positive regulation of prostaglandin secretion (GO:0032308)2.71700492
103cornea development in camera-type eye (GO:0061303)2.69944497
104regulation of synapse assembly (GO:0051963)2.69772108
105long-chain fatty acid biosynthetic process (GO:0042759)2.68750486
106dopamine biosynthetic process (GO:0042416)2.67358327
107negative regulation of myoblast differentiation (GO:0045662)2.66743136
108positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.66121674
109interleukin-6-mediated signaling pathway (GO:0070102)2.64698224
110regulation of inositol phosphate biosynthetic process (GO:0010919)2.63841384
111female gonad development (GO:0008585)2.62998437
112neuron recognition (GO:0008038)2.61305912
113negative regulation of execution phase of apoptosis (GO:1900118)2.60896250
114positive regulation of protein autophosphorylation (GO:0031954)2.60404147
115vocalization behavior (GO:0071625)2.59400228
116short-term memory (GO:0007614)2.59352833
117L-amino acid import (GO:0043092)2.59259751
118positive regulation of chromosome segregation (GO:0051984)2.59061177
119male meiosis I (GO:0007141)2.58429942
120pyrimidine-containing compound transmembrane transport (GO:0072531)2.58189354
121regulation of alkaline phosphatase activity (GO:0010692)2.56914263
122negative regulation of keratinocyte proliferation (GO:0010839)2.56859346
123phosphorelay signal transduction system (GO:0000160)2.56603382
124epithelial cilium movement (GO:0003351)2.56570732
125cell differentiation involved in kidney development (GO:0061005)2.56169406
126photoreceptor cell differentiation (GO:0046530)2.55286801
127eye photoreceptor cell differentiation (GO:0001754)2.55286801
128kidney morphogenesis (GO:0060993)2.54614579
129mesonephros development (GO:0001823)2.53779370
130regulation of G0 to G1 transition (GO:0070316)2.53735414
131reflex (GO:0060004)2.53155219
132relaxation of smooth muscle (GO:0044557)2.52689248
133ossification (GO:0001503)2.52580225
134regulation of meiotic cell cycle (GO:0051445)2.52533323
135adult feeding behavior (GO:0008343)2.51827750
136regulation of prostaglandin secretion (GO:0032306)2.51746577
137DNA methylation (GO:0006306)2.51349112
138DNA alkylation (GO:0006305)2.51349112
139inner ear receptor stereocilium organization (GO:0060122)2.51190516
140detection of light stimulus involved in visual perception (GO:0050908)2.51050106
141detection of light stimulus involved in sensory perception (GO:0050962)2.51050106
142cell proliferation in forebrain (GO:0021846)2.50222811
143N-terminal protein amino acid acetylation (GO:0006474)2.49543864
144oogenesis (GO:0048477)2.48671134
145genitalia morphogenesis (GO:0035112)2.48604157
146positive regulation of steroid hormone secretion (GO:2000833)2.48498161
147organ growth (GO:0035265)2.47333899
148ganglion development (GO:0061548)2.46321597
149transmission of nerve impulse (GO:0019226)2.46045413
150anatomical structure arrangement (GO:0048532)2.45776771
151ionotropic glutamate receptor signaling pathway (GO:0035235)2.45348526
152G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.44879193
153negative regulation of homotypic cell-cell adhesion (GO:0034111)2.44392336
154extracellular regulation of signal transduction (GO:1900115)2.42264280
155extracellular negative regulation of signal transduction (GO:1900116)2.42264280
156photoreceptor cell maintenance (GO:0045494)2.41543546
157regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.41061872
158cilium movement (GO:0003341)2.40989203
159response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.40661542
160cell differentiation involved in metanephros development (GO:0072202)2.40000338
161positive regulation of protein kinase C signaling (GO:0090037)2.39212050
162axonal fasciculation (GO:0007413)2.38755608
163dentate gyrus development (GO:0021542)2.38604661
164adenosine metabolic process (GO:0046085)2.38442332
165regulation of pigment cell differentiation (GO:0050932)2.36999759
166serotonin receptor signaling pathway (GO:0007210)2.35636035
167glutamate receptor signaling pathway (GO:0007215)2.35123137
168polyol transport (GO:0015791)2.33917454
169central nervous system projection neuron axonogenesis (GO:0021952)2.33760889
170drinking behavior (GO:0042756)2.33646966
171positive regulation of meiosis (GO:0045836)2.33070560
172lymphoid progenitor cell differentiation (GO:0002320)2.32000178
173developmental pigmentation (GO:0048066)2.31483884
174protein heterotetramerization (GO:0051290)2.30863813
175regulation of male gonad development (GO:2000018)2.30858086
176centriole assembly (GO:0098534)2.30092716
177spinal cord motor neuron differentiation (GO:0021522)2.29727504
178regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.29469862
179mesenchymal-epithelial cell signaling (GO:0060638)2.28485130
180male sex determination (GO:0030238)2.28463316
181calcium ion import (GO:0070509)2.27268940
182glucosamine-containing compound catabolic process (GO:1901072)2.26929852
183regulation of platelet aggregation (GO:0090330)2.26533871
184positive regulation of uterine smooth muscle contraction (GO:0070474)2.26380734
185negative regulation of leukocyte chemotaxis (GO:0002689)2.25713066
186positive regulation of meiotic cell cycle (GO:0051446)2.24628677
187cerebral cortex cell migration (GO:0021795)2.23136986
188forebrain neuron differentiation (GO:0021879)2.23119368
189otic vesicle formation (GO:0030916)2.22749749
190DNA integration (GO:0015074)2.22725910
191activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.20995039
192response to pheromone (GO:0019236)2.20656164
193nucleotide transmembrane transport (GO:1901679)2.20361119
194oligodendrocyte differentiation (GO:0048709)2.19849926

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.89512584
2GBX2_23144817_ChIP-Seq_PC3_Human3.88042136
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.52500284
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.52440608
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71640110
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.66781364
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.62917026
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.53103381
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.46084536
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.42911477
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.38778759
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35187193
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31255249
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28451255
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.23378182
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23125277
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.21785591
18TAF15_26573619_Chip-Seq_HEK293_Human2.21706247
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19353699
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.17323972
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14109412
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12003442
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.06862850
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.06862850
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04555280
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.04534186
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.04519311
28FLI1_27457419_Chip-Seq_LIVER_Mouse2.02911726
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95501440
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.94437852
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.89583924
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.84324001
33P300_19829295_ChIP-Seq_ESCs_Human1.83940948
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83099063
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.79853043
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.79289107
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77178498
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.75562399
39RNF2_27304074_Chip-Seq_NSC_Mouse1.74405833
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.72655461
41AR_21572438_ChIP-Seq_LNCaP_Human1.71607340
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.69456642
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.69371055
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68626026
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68530803
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.68368660
47CBP_20019798_ChIP-Seq_JUKART_Human1.68368660
48* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.67967691
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.67958015
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.67817527
51EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.65663462
52VDR_22108803_ChIP-Seq_LS180_Human1.64400251
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.63357383
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.63220997
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63057387
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62748479
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.62714543
58AHR_22903824_ChIP-Seq_MCF-7_Human1.61523157
59* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59928252
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57510993
61IGF1R_20145208_ChIP-Seq_DFB_Human1.56058831
62MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55392875
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54748403
64E2F1_18555785_Chip-Seq_ESCs_Mouse1.54689337
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.54149842
66P53_22387025_ChIP-Seq_ESCs_Mouse1.54128765
67SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53771844
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.52964189
69SUZ12_18555785_Chip-Seq_ESCs_Mouse1.52346282
70SMAD4_21799915_ChIP-Seq_A2780_Human1.51555453
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.48895466
72TP53_16413492_ChIP-PET_HCT116_Human1.48617153
73EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.47768251
74BP1_19119308_ChIP-ChIP_Hs578T_Human1.47233509
75CJUN_26792858_Chip-Seq_BT549_Human1.46800173
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.46251549
77ER_23166858_ChIP-Seq_MCF-7_Human1.45197062
78KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44675507
79KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44675507
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44675507
81CMYC_18555785_Chip-Seq_ESCs_Mouse1.43267073
82TP53_18474530_ChIP-ChIP_U2OS_Human1.42426755
83FUS_26573619_Chip-Seq_HEK293_Human1.42333831
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.41268029
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.40632956
86P300_18555785_Chip-Seq_ESCs_Mouse1.40343012
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39631397
88NMYC_18555785_Chip-Seq_ESCs_Mouse1.39294994
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.37344673
90RUNX1_27457419_Chip-Seq_LIVER_Mouse1.37201236
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35557492
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35401075
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33707256
94BCAT_22108803_ChIP-Seq_LS180_Human1.32793524
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30983070
96SOX2_18555785_Chip-Seq_ESCs_Mouse1.30979540
97* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30848590
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30844516
99* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29896388
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29444061
101WT1_19549856_ChIP-ChIP_CCG9911_Human1.28491108
102CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28169340
103TP63_19390658_ChIP-ChIP_HaCaT_Human1.27899690
104OCT4_18555785_Chip-Seq_ESCs_Mouse1.27808985
105TAL1_26923725_Chip-Seq_HPCs_Mouse1.27044881
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25904420
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.25786574
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24032644
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24032644
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23250311
111PU1_27457419_Chip-Seq_LIVER_Mouse1.23141709
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23102773
113KLF4_18555785_Chip-Seq_ESCs_Mouse1.22598801
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22586713
115ZFX_18555785_Chip-Seq_ESCs_Mouse1.22372197
116ESRRB_18555785_Chip-Seq_ESCs_Mouse1.20807525
117CDX2_22108803_ChIP-Seq_LS180_Human1.19794328
118* RUNX2_22187159_ChIP-Seq_PCA_Human1.19122274
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18855307
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.18714946
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17905767
122CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17726964
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16686843
124AR_25329375_ChIP-Seq_VCAP_Human1.16636736
125CTCF_18555785_Chip-Seq_ESCs_Mouse1.16529494
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.16234831
127SMAD1_18555785_Chip-Seq_ESCs_Mouse1.16070433
128EWS_26573619_Chip-Seq_HEK293_Human1.15987344
129STAT3_23295773_ChIP-Seq_U87_Human1.15851142
130NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15554024
131ZNF274_21170338_ChIP-Seq_K562_Hela1.14832506
132NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13245910
133OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13231286
134ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11746250
135* TCF4_23295773_ChIP-Seq_U87_Human1.11515065
136* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11278001
137DROSHA_22980978_ChIP-Seq_HELA_Human1.11188975
138* SMAD4_21741376_ChIP-Seq_EPCs_Human1.11098988
139* TP63_23658742_ChIP-Seq_EP156T_Human1.10256452
140ARNT_22903824_ChIP-Seq_MCF-7_Human1.09582390
141SMAD3_21741376_ChIP-Seq_HESCs_Human1.08609212
142ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01006550
143TCF4_22108803_ChIP-Seq_LS180_Human0.97187438
144SMRT_27268052_Chip-Seq_Bcells_Human0.93875439
145CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92584447
146* SOX2_21211035_ChIP-Seq_LN229_Gbm0.91562303
147RXR_22108803_ChIP-Seq_LS180_Human0.91475990
148KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90881431
149NANOG_19829295_ChIP-Seq_ESCs_Human0.90554846
150SOX2_19829295_ChIP-Seq_ESCs_Human0.90554846

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis5.97716188
2* MP0003718_maternal_effect5.46256487
3MP0001188_hyperpigmentation3.86966919
4MP0003283_abnormal_digestive_organ3.86339972
5MP0006292_abnormal_olfactory_placode3.81942620
6MP0008877_abnormal_DNA_methylation3.79202516
7MP0002102_abnormal_ear_morphology3.60726987
8MP0003136_yellow_coat_color3.47281936
9MP0000566_synostosis3.22911418
10* MP0005395_other_phenotype3.12315043
11MP0003880_abnormal_central_pattern2.76666073
12MP0008057_abnormal_DNA_replication2.62772731
13MP0003183_abnormal_peptide_metabolism2.59411465
14MP0002138_abnormal_hepatobiliary_system2.59154316
15MP0003950_abnormal_plasma_membrane2.58391207
16MP0005409_darkened_coat_color2.50505355
17MP0010368_abnormal_lymphatic_system2.50402524
18MP0004381_abnormal_hair_follicle2.40019463
19MP0005171_absent_coat_pigmentation2.29131759
20MP0002139_abnormal_hepatobiliary_system2.24357442
21MP0002277_abnormal_respiratory_mucosa2.21540358
22MP0003890_abnormal_embryonic-extraembry2.21096203
23MP0010234_abnormal_vibrissa_follicle2.01111651
24MP0005503_abnormal_tendon_morphology2.00343717
25MP0004742_abnormal_vestibular_system1.95093902
26MP0005083_abnormal_biliary_tract1.94549626
27MP0001486_abnormal_startle_reflex1.93791689
28MP0005085_abnormal_gallbladder_physiolo1.93613240
29MP0001542_abnormal_bone_strength1.89765204
30MP0003699_abnormal_female_reproductive1.89345301
31MP0000049_abnormal_middle_ear1.89250975
32MP0002876_abnormal_thyroid_physiology1.87678787
33MP0003938_abnormal_ear_development1.79602591
34MP0002638_abnormal_pupillary_reflex1.76446071
35MP0005646_abnormal_pituitary_gland1.75452122
36MP0008995_early_reproductive_senescence1.74393939
37* MP0009250_abnormal_appendicular_skeleto1.73150898
38MP0002168_other_aberrant_phenotype1.67319239
39MP0000631_abnormal_neuroendocrine_gland1.63300996
40MP0001929_abnormal_gametogenesis1.61146081
41MP0001346_abnormal_lacrimal_gland1.56513476
42MP0002210_abnormal_sex_determination1.55874527
43MP0005645_abnormal_hypothalamus_physiol1.55606724
44* MP0000026_abnormal_inner_ear1.54861047
45MP0009780_abnormal_chondrocyte_physiolo1.54607876
46MP0010386_abnormal_urinary_bladder1.53815034
47MP0004134_abnormal_chest_morphology1.53522905
48MP0008260_abnormal_autophagy1.53050743
49MP0002234_abnormal_pharynx_morphology1.51579918
50MP0002249_abnormal_larynx_morphology1.51485193
51MP0000015_abnormal_ear_pigmentation1.49882978
52MP0001986_abnormal_taste_sensitivity1.45637151
53MP0010678_abnormal_skin_adnexa1.44844222
54MP0009745_abnormal_behavioral_response1.43733277
55MP0005647_abnormal_sex_gland1.43683295
56MP0009379_abnormal_foot_pigmentation1.42585887
57MP0000653_abnormal_sex_gland1.41641972
58MP0006276_abnormal_autonomic_nervous1.40066832
59MP0003252_abnormal_bile_duct1.38133184
60MP0005423_abnormal_somatic_nervous1.37980408
61MP0003787_abnormal_imprinting1.37369477
62MP0010030_abnormal_orbit_morphology1.36807095
63MP0000778_abnormal_nervous_system1.33462630
64MP0002557_abnormal_social/conspecific_i1.33231341
65MP0009046_muscle_twitch1.32520876
66MP0002735_abnormal_chemical_nociception1.29842528
67* MP0003795_abnormal_bone_structure1.29732575
68MP0000427_abnormal_hair_cycle1.28929015
69MP0005360_urolithiasis1.28657592
70MP0003937_abnormal_limbs/digits/tail_de1.28560910
71MP0001968_abnormal_touch/_nociception1.28321564
72MP0005379_endocrine/exocrine_gland_phen1.28205031
73MP0005174_abnormal_tail_pigmentation1.28018511
74MP0008789_abnormal_olfactory_epithelium1.25754454
75MP0001984_abnormal_olfaction1.24779361
76MP0002177_abnormal_outer_ear1.24656858
77MP0005257_abnormal_intraocular_pressure1.24329950
78MP0002938_white_spotting1.23546203
79* MP0001963_abnormal_hearing_physiology1.23156302
80MP0002272_abnormal_nervous_system1.23083888
81MP0005389_reproductive_system_phenotype1.23031771
82MP0003385_abnormal_body_wall1.22465617
83MP0003315_abnormal_perineum_morphology1.21565548
84MP0000579_abnormal_nail_morphology1.21271088
85MP0005551_abnormal_eye_electrophysiolog1.20592980
86MP0000762_abnormal_tongue_morphology1.19686296
87MP0001666_abnormal_nutrient_absorption1.19626038
88MP0003941_abnormal_skin_development1.19502197
89MP0003935_abnormal_craniofacial_develop1.19234529
90MP0002233_abnormal_nose_morphology1.18179602
91MP0002067_abnormal_sensory_capabilities1.16389342
92MP0002572_abnormal_emotion/affect_behav1.15387177
93* MP0002998_abnormal_bone_remodeling1.14724105
94MP0001119_abnormal_female_reproductive1.12896369
95MP0002161_abnormal_fertility/fecundity1.12278838
96MP0002184_abnormal_innervation1.11822770
97MP0001881_abnormal_mammary_gland1.11746680
98MP0008004_abnormal_stomach_pH1.11702427
99MP0005275_abnormal_skin_tensile1.11355537
100MP0001905_abnormal_dopamine_level1.08908792
101MP0001145_abnormal_male_reproductive1.08227114
102MP0005410_abnormal_fertilization1.07720803
103MP0003635_abnormal_synaptic_transmissio1.06748566
104MP0003879_abnormal_hair_cell1.06667250
105MP0006072_abnormal_retinal_apoptosis1.05998121
106MP0000681_abnormal_thyroid_gland1.05103256
107MP0001485_abnormal_pinna_reflex1.04569351
108MP0001501_abnormal_sleep_pattern1.03965263
109* MP0005390_skeleton_phenotype1.03482305
110MP0001533_abnormal_skeleton_physiology1.02927721
111MP0003755_abnormal_palate_morphology1.01851980
112MP0003868_abnormal_feces_composition1.01810326
113MP0002736_abnormal_nociception_after1.01422593
114* MP0002752_abnormal_somatic_nervous0.99376926
115MP0002064_seizures0.98627125
116MP0005187_abnormal_penis_morphology0.98002734
117* MP0002116_abnormal_craniofacial_bone0.97546825
118MP0001919_abnormal_reproductive_system0.96082965
119MP0001879_abnormal_lymphatic_vessel0.96081991
120MP0000462_abnormal_digestive_system0.95244605
121MP0003045_fibrosis0.95192046
122MP0005023_abnormal_wound_healing0.94588189
123MP0002160_abnormal_reproductive_system0.93860727
124MP0005084_abnormal_gallbladder_morpholo0.93658629
125* MP0002113_abnormal_skeleton_development0.93316356
126MP0008875_abnormal_xenobiotic_pharmacok0.93283122
127MP0005394_taste/olfaction_phenotype0.93218164
128MP0005499_abnormal_olfactory_system0.93218164
129MP0000383_abnormal_hair_follicle0.91666069
130MP0002734_abnormal_mechanical_nocicepti0.91533701
131MP0001440_abnormal_grooming_behavior0.89330076
132MP0004233_abnormal_muscle_weight0.89199368
133* MP0002109_abnormal_limb_morphology0.88655272
134MP0004133_heterotaxia0.88555394
135MP0000613_abnormal_salivary_gland0.88203183
136MP0002063_abnormal_learning/memory/cond0.87388227
137MP0004142_abnormal_muscle_tone0.85966880
138MP0003698_abnormal_male_reproductive0.85437190
139MP0005253_abnormal_eye_physiology0.82906539
140* MP0002115_abnormal_skeleton_extremities0.82810689
141* MP0000163_abnormal_cartilage_morphology0.82561113
142MP0005248_abnormal_Harderian_gland0.82485419
143MP0000432_abnormal_head_morphology0.82413677
144* MP0002896_abnormal_bone_mineralization0.82359312
145MP0002751_abnormal_autonomic_nervous0.81119855
146MP0008438_abnormal_cutaneous_collagen0.80042314
147MP0005451_abnormal_body_composition0.79050636
148MP0001502_abnormal_circadian_rhythm0.78829527
149MP0000569_abnormal_digit_pigmentation0.78118500
150MP0000372_irregular_coat_pigmentation0.78038282
151MP0003936_abnormal_reproductive_system0.76029149
152MP0002163_abnormal_gland_morphology0.75975993
153* MP0005508_abnormal_skeleton_morphology0.74961836
154MP0000920_abnormal_myelination0.74509100
155MP0002108_abnormal_muscle_morphology0.73167573
156MP0002132_abnormal_respiratory_system0.73075863
157MP0002882_abnormal_neuron_morphology0.70795771
158MP0000647_abnormal_sebaceous_gland0.70464764
159MP0002090_abnormal_vision0.70227632
160MP0000767_abnormal_smooth_muscle0.68441110
161MP0004084_abnormal_cardiac_muscle0.68309696
162MP0008058_abnormal_DNA_repair0.67747807
163MP0000627_abnormal_mammary_gland0.61957093
164MP0002127_abnormal_cardiovascular_syste0.61045625
165MP0004924_abnormal_behavior0.60947845
166MP0005386_behavior/neurological_phenoty0.60947845
167MP0010307_abnormal_tumor_latency0.58944704
168* MP0001664_abnormal_digestion0.57988958
169MP0000465_gastrointestinal_hemorrhage0.57974051
170MP0002928_abnormal_bile_duct0.57299724
171MP0009697_abnormal_copulation0.54617736
172MP0005365_abnormal_bile_salt0.54418134

Predicted human phenotypes

RankGene SetZ-score
1Increased density of long bones (HP:0006392)6.98228268
2* Hypophosphatemic rickets (HP:0004912)6.78975858
3* Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.12283287
4Abnormality of the vertebral endplates (HP:0005106)5.43265390
5Gonadotropin excess (HP:0000837)4.98541900
6Overgrowth (HP:0001548)4.69494352
7Facial diplegia (HP:0001349)4.64375369
8Broad ribs (HP:0000885)4.19493522
9Absent/shortened dynein arms (HP:0200106)4.12178236
10Dynein arm defect of respiratory motile cilia (HP:0012255)4.12178236
11Septo-optic dysplasia (HP:0100842)3.94736832
12Irregular vertebral endplates (HP:0003301)3.75116619
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.64430025
14Enlarged epiphyses (HP:0010580)3.60831053
15Mild short stature (HP:0003502)3.60493373
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.59747924
17Abnormal ciliary motility (HP:0012262)3.53359563
18Metaphyseal cupping (HP:0003021)3.52755358
19* Abnormality of calcium-phosphate metabolism (HP:0100530)3.43300082
20Flared iliac wings (HP:0002869)3.27043356
21Febrile seizures (HP:0002373)3.26821416
22Male infertility (HP:0003251)3.26329161
23Supernumerary spleens (HP:0009799)3.22911344
24Morphological abnormality of the middle ear (HP:0008609)3.08310771
25Abnormality of incisor morphology (HP:0011063)3.06120589
26* Cranial hyperostosis (HP:0004437)3.03059110
27Coxa vara (HP:0002812)2.99678664
28Aplasia cutis congenita (HP:0001057)2.99006454
29Chromsome breakage (HP:0040012)2.97821484
30White forelock (HP:0002211)2.97565052
31Upper limb muscle weakness (HP:0003484)2.95948970
32Abnormality of the phalanges of the hallux (HP:0010057)2.95471681
33Papillary thyroid carcinoma (HP:0002895)2.92815518
34Abnormal respiratory motile cilium physiology (HP:0012261)2.91846153
35Patchy hypopigmentation of hair (HP:0011365)2.87947231
36Focal motor seizures (HP:0011153)2.87479540
37Aplasia/Hypoplasia of the fovea (HP:0008060)2.85189840
38Hypoplasia of the fovea (HP:0007750)2.85189840
39Abnormal respiratory epithelium morphology (HP:0012253)2.84139272
40Abnormal respiratory motile cilium morphology (HP:0005938)2.84139272
41Gonadal dysgenesis (HP:0000133)2.77453123
42Absent septum pellucidum (HP:0001331)2.77340128
43* Craniofacial hyperostosis (HP:0004493)2.76351232
44Optic nerve hypoplasia (HP:0000609)2.71519617
45Cupped ribs (HP:0000887)2.71205540
46Duplicated collecting system (HP:0000081)2.71057122
47Abnormality of the renal collecting system (HP:0004742)2.67383138
48Short middle phalanx of finger (HP:0005819)2.65213794
49Persistence of primary teeth (HP:0006335)2.64842793
50Congenital sensorineural hearing impairment (HP:0008527)2.64400017
51Constricted visual fields (HP:0001133)2.55471488
52Aplasia involving bones of the upper limbs (HP:0009823)2.55359189
53Aplasia of the phalanges of the hand (HP:0009802)2.55359189
54Aplasia involving bones of the extremities (HP:0009825)2.55359189
55Choanal stenosis (HP:0000452)2.55158115
56Tubulointerstitial nephritis (HP:0001970)2.53840182
57Conical tooth (HP:0000698)2.53237335
58Abnormality of femoral epiphyses (HP:0006499)2.52615679
59Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.52615679
60Infertility (HP:0000789)2.50657840
61Premature ovarian failure (HP:0008209)2.50115158
62Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.50056568
63Lip pit (HP:0100267)2.49114684
64Abnormality of the septum pellucidum (HP:0007375)2.48558838
65Prostate neoplasm (HP:0100787)2.48253411
66* Rickets (HP:0002748)2.47912981
67Abnormality of the epiphysis of the femoral head (HP:0010574)2.47333060
68Oligodactyly (hands) (HP:0001180)2.46929606
69Abnormality of the renal medulla (HP:0100957)2.46748949
70Azoospermia (HP:0000027)2.45966111
71Parakeratosis (HP:0001036)2.45866804
72* Genu varum (HP:0002970)2.45061010
73Renal cortical cysts (HP:0000803)2.44920171
74Nasolacrimal duct obstruction (HP:0000579)2.44026247
75Abnormality of the proximal phalanges of the hand (HP:0009834)2.43546415
76Hyperventilation (HP:0002883)2.42157078
77Abnormality of carpal bone ossification (HP:0006257)2.41737438
78Nephronophthisis (HP:0000090)2.40550993
79Abnormality of the fovea (HP:0000493)2.39933783
80Fair hair (HP:0002286)2.37553479
81Facial hemangioma (HP:0000329)2.36898077
82Mixed hearing impairment (HP:0000410)2.36715587
83Sudden death (HP:0001699)2.36493275
84Spondylolisthesis (HP:0003302)2.35563280
85Aplasia/Hypoplasia of the tibia (HP:0005772)2.35279462
86Abnormality of the femoral head (HP:0003368)2.31280277
87Abnormality of the nasal septum (HP:0000419)2.30312904
88Hypoplasia of the uterus (HP:0000013)2.29235231
89Short tibia (HP:0005736)2.24537912
90Duplication of thumb phalanx (HP:0009942)2.23625433
91Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.20233915
92Neonatal short-limb short stature (HP:0008921)2.20154114
93Decreased central vision (HP:0007663)2.19834141
94Abnormality of the lacrimal duct (HP:0011481)2.18846026
95* Tibial bowing (HP:0002982)2.16663822
96Metaphyseal dysplasia (HP:0100255)2.16175256
97Abnormality of the phalanges of the 2nd finger (HP:0009541)2.14964734
98Striae distensae (HP:0001065)2.14815367
99Relative macrocephaly (HP:0004482)2.14185095
100Abnormality of the nasolacrimal system (HP:0000614)2.14068409
101Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14037191
102Abnormality of the 1st metacarpal (HP:0010009)2.11212332
103Abnormal hand bone ossification (HP:0010660)2.10635516
104Abnormality of the middle phalanges of the toes (HP:0010183)2.08758798
105Fibular hypoplasia (HP:0003038)2.07744194
106Abnormality of primary teeth (HP:0006481)2.05961812
107Abnormal hair whorl (HP:0010721)2.05159266
108Abnormality of abdominal situs (HP:0011620)2.02795224
109Abdominal situs inversus (HP:0003363)2.02795224
110Bell-shaped thorax (HP:0001591)2.01345343
111Atelectasis (HP:0100750)2.00975327
112* Femoral bowing (HP:0002980)2.00134791
113Papilledema (HP:0001085)11.8117133
114Epileptic encephalopathy (HP:0200134)1.98674430
115Thyroid-stimulating hormone excess (HP:0002925)1.97977604
116Wrist flexion contracture (HP:0001239)1.97458189
117Overfolded helix (HP:0000396)1.96574506
118Attenuation of retinal blood vessels (HP:0007843)1.96304875
119Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.96178433
120Ovoid vertebral bodies (HP:0003300)1.95461118
121Stomach cancer (HP:0012126)1.93771530
122Abnormality of secondary sexual hair (HP:0009888)1.92630858
123Abnormality of the axillary hair (HP:0100134)1.92630858
124Absent frontal sinuses (HP:0002688)1.91138049
125Cupped ear (HP:0000378)1.89017084
126Congenital stationary night blindness (HP:0007642)1.88902274
127Absent speech (HP:0001344)1.88783817
128Abnormality of molar morphology (HP:0011070)1.88636667
129Abnormality of molar (HP:0011077)1.88636667
130Protruding tongue (HP:0010808)1.88108110
131Cutaneous finger syndactyly (HP:0010554)1.86698298
132Abnormality of dentin (HP:0010299)1.86377605
133Hypoplastic iliac wings (HP:0002866)1.86224032
134Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.83266493
135Thyroid carcinoma (HP:0002890)1.81640098
136Hypothermia (HP:0002045)1.80943772
137Concave nail (HP:0001598)1.80686770
138Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.79931832
139Corneal dystrophy (HP:0001131)1.79535374
140Submucous cleft hard palate (HP:0000176)1.79320319
141Pulmonary artery stenosis (HP:0004415)1.78989055
142Limited hip movement (HP:0008800)1.78491511
143Broad-based gait (HP:0002136)1.78054247
144Carpal bone hypoplasia (HP:0001498)1.78030055
145Wormian bones (HP:0002645)1.78016691
146Generalized hypopigmentation of hair (HP:0011358)1.77144884
147Enlarged penis (HP:0000040)1.76905880
148Enlarged kidneys (HP:0000105)1.76102996
149Decreased lacrimation (HP:0000633)1.75673157
150Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.74800646
151Rhinitis (HP:0012384)1.73858483
152Male pseudohermaphroditism (HP:0000037)1.73737653
153Abnormality of the frontal sinuses (HP:0002687)1.73135761
154Cholecystitis (HP:0001082)1.73103491
155Abnormal gallbladder physiology (HP:0012438)1.73103491
156Xerostomia (HP:0000217)1.72036952
157Increased corneal curvature (HP:0100692)1.71177332
158Keratoconus (HP:0000563)1.71177332
159Abnormality of the parietal bone (HP:0002696)1.70379145
160Median cleft lip (HP:0000161)1.69212665
161Adrenal hypoplasia (HP:0000835)1.69133802
162Absent rod-and cone-mediated responses on ERG (HP:0007688)1.69092636
163Abnormal spermatogenesis (HP:0008669)1.68946868
164Aplasia/Hypoplasia of the tongue (HP:0010295)1.68174465
165Abnormal sex determination (HP:0012244)1.68009507
166Sex reversal (HP:0012245)1.68009507
167Anterior segment dysgenesis (HP:0007700)1.67458159
168Abnormal ossification of hand bones (HP:0005921)1.67135339
169Prolonged neonatal jaundice (HP:0006579)1.66902213
170Stage 5 chronic kidney disease (HP:0003774)1.66457870
171Aplasia/Hypoplasia of the lens (HP:0008063)1.66039042
172Abnormality of the renal cortex (HP:0011035)1.65860840
173Alacrima (HP:0000522)1.65685812
174Fibular aplasia (HP:0002990)1.65425430
175Abnormality of the acetabulum (HP:0003170)1.64394292
176Humeroradial synostosis (HP:0003041)1.64394027
177Synostosis involving the elbow (HP:0003938)1.64394027
178Abnormality of the dental pulp (HP:0006479)1.64374856
179Abnormality of the middle phalanges of the hand (HP:0009833)1.64264940
180Small epiphyses (HP:0010585)1.64127067
181Gaze-evoked nystagmus (HP:0000640)1.61484844
182Aplasia/hypoplasia of the uterus (HP:0008684)1.61108991
183Nausea (HP:0002018)1.60520455
184Abnormality of the epiphyses of the hand (HP:0005924)1.60051783
185Short femoral neck (HP:0100864)1.59916168
186Abnormality of macular pigmentation (HP:0008002)1.59370858
187Increased number of teeth (HP:0011069)1.59147850
188Capillary hemangiomas (HP:0005306)1.58882029
189Secondary amenorrhea (HP:0000869)1.56580293
190Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.56521004

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.80309934
2MAP3K95.11814615
3ARAF4.60312837
4MST43.66211152
5TNIK3.10811673
6TAOK32.96940556
7MET2.88113516
8STK242.87427262
9BLK2.76185969
10INSRR2.68597194
11STK162.63368856
12MKNK22.47801009
13BMPR1B2.28661225
14EIF2AK22.22109896
15EIF2AK32.07644359
16MOS1.98427921
17CDK91.96303319
18TRIM281.89758355
19NEK91.89034201
20MELK1.86377771
21BRAF1.84272463
22NTRK31.83225641
23MUSK1.81796032
24MAP2K71.72000654
25MAP3K141.65573037
26PKN11.65191018
27STK31.64440833
28NEK61.63320036
29GRK11.59274754
30IRAK41.58468795
31KSR11.56367055
32CDK31.55225485
33YES11.50416763
34ADRBK21.50046279
35ZAK1.49700550
36RAF11.48350527
37MKNK11.47905764
38KSR21.44630047
39MAPK131.41779182
40STK391.41103108
41BMPR21.33250291
42GRK71.30858653
43PRPF4B1.29922418
44IRAK31.29712765
45EPHA31.27018984
46OXSR11.26131043
47TXK1.20855058
48EPHA41.20801386
49PRKCI1.20540236
50TNK21.14721025
51BRSK21.12254149
52DMPK1.11575569
53DDR21.10728260
54NUAK11.08914884
55MAP3K41.06300216
56IRAK11.06065074
57TGFBR21.05800925
58TTK1.05157451
59SIK31.03172156
60PBK1.01352262
61SIK21.00893257
62AURKA0.99972167
63PIK3CA0.95336961
64IRAK20.93764148
65MARK10.93154490
66NLK0.92104975
67CDK120.91958942
68PRKCE0.91838591
69BCR0.89995128
70EPHB20.89699209
71CDK70.89604200
72LATS10.87670445
73ACVR1B0.86642876
74BRD40.86520177
75FES0.86345326
76PIK3CG0.83144619
77TGFBR10.77055319
78NTRK20.76429856
79TRPM70.75851814
80AKT30.75720297
81PNCK0.72816291
82MAPK150.72200425
83CLK10.72076302
84FRK0.70487728
85DYRK1A0.68430413
86DYRK20.67689565
87CAMK2A0.67235761
88FGR0.65880773
89WNK10.65711322
90PRKG10.64140814
91TIE10.63842699
92PLK10.63519490
93TEC0.62627006
94CAMK2B0.62123791
95PTK2B0.60777673
96RIPK40.59863940
97MAPKAPK30.59397356
98TAOK20.58840936
99CHUK0.58840305
100PINK10.58342697
101CSNK1A1L0.57866695
102TLK10.56135569
103PLK30.55238814
104MAP3K120.54478259
105MAP2K10.53308627
106MYLK0.52977701
107WNK30.51605043
108PRKD20.51600557
109CSNK1D0.50547500
110PTK20.50195738
111CAMK10.49166325
112CAMK1G0.48637055
113CAMK2D0.47842034
114SGK20.47840621
115CSF1R0.47714912
116PRKCQ0.47145815
117ADRBK10.46801936
118SGK2230.46772118
119SGK4940.46772118
120ATM0.45870680
121FER0.45612928
122MARK20.45000623
123STK38L0.44658445
124UHMK10.44641273
125SGK10.44516595
126MAP3K130.43223479
127IKBKB0.42271577
128MAPK70.40431843
129PLK20.39477697
130MST1R0.38860526
131MAPKAPK50.38143385
132MAPK120.38002774
133PRKCG0.37949057
134ERBB30.37171022
135PRKACA0.37092105
136CSNK1G30.36678410
137PRKAA20.36573314
138ERBB40.36128832
139SRPK10.35775306
140CDC42BPA0.35654734
141WNK40.35600452
142MAP3K50.35271291
143FGFR20.34263533
144CSNK1G10.33959958
145CDK80.33742781
146ROCK20.33718676
147ROCK10.33576949
148PIM10.33392221
149CHEK10.32886868
150FLT30.32364233
151MAPK100.31659107
152CDC70.31519260
153PAK10.30824853
154STK380.29797240
155CSNK1G20.29585049
156MAP3K70.28038832
157PDK10.27990621
158CDK10.25729402

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.40618993
2Dorso-ventral axis formation_Homo sapiens_hsa043202.94354164
3Nicotine addiction_Homo sapiens_hsa050332.93868023
4Caffeine metabolism_Homo sapiens_hsa002322.93212267
5Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.47730916
6Phototransduction_Homo sapiens_hsa047442.43586439
7TGF-beta signaling pathway_Homo sapiens_hsa043502.37259093
8Cell cycle_Homo sapiens_hsa041102.12232255
9Autoimmune thyroid disease_Homo sapiens_hsa053202.11752288
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96883481
11Taste transduction_Homo sapiens_hsa047421.95609101
12Sphingolipid metabolism_Homo sapiens_hsa006001.91669362
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.86908788
14Serotonergic synapse_Homo sapiens_hsa047261.82479887
15Oocyte meiosis_Homo sapiens_hsa041141.74934780
16Morphine addiction_Homo sapiens_hsa050321.73699108
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.69833647
18Ether lipid metabolism_Homo sapiens_hsa005651.69003874
19Axon guidance_Homo sapiens_hsa043601.66590085
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.66275896
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.62823645
22Glutamatergic synapse_Homo sapiens_hsa047241.60643945
23Arachidonic acid metabolism_Homo sapiens_hsa005901.53922388
24RNA degradation_Homo sapiens_hsa030181.51592824
25Fanconi anemia pathway_Homo sapiens_hsa034601.51517357
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50388360
27ABC transporters_Homo sapiens_hsa020101.49165188
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.47759668
29Focal adhesion_Homo sapiens_hsa045101.39520901
30Rheumatoid arthritis_Homo sapiens_hsa053231.35152042
31Ovarian steroidogenesis_Homo sapiens_hsa049131.31126486
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30668813
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29771376
34ECM-receptor interaction_Homo sapiens_hsa045121.26022103
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.23814571
36Adherens junction_Homo sapiens_hsa045201.22924778
37Linoleic acid metabolism_Homo sapiens_hsa005911.22056345
38Non-homologous end-joining_Homo sapiens_hsa034501.21919413
39GABAergic synapse_Homo sapiens_hsa047271.16107732
40Mismatch repair_Homo sapiens_hsa034301.15550970
41Circadian entrainment_Homo sapiens_hsa047131.13538699
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.11952777
43Calcium signaling pathway_Homo sapiens_hsa040201.11826820
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10779575
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10551668
46Collecting duct acid secretion_Homo sapiens_hsa049661.09277922
47Thyroid cancer_Homo sapiens_hsa052161.08605979
48Graft-versus-host disease_Homo sapiens_hsa053321.08381277
49Olfactory transduction_Homo sapiens_hsa047401.07110242
50Melanoma_Homo sapiens_hsa052181.06876357
51Wnt signaling pathway_Homo sapiens_hsa043101.03444481
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02909155
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99550780
54Salivary secretion_Homo sapiens_hsa049700.99121191
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97084824
56Asthma_Homo sapiens_hsa053100.95744004
57Basal cell carcinoma_Homo sapiens_hsa052170.95248331
58p53 signaling pathway_Homo sapiens_hsa041150.94344829
59Long-term depression_Homo sapiens_hsa047300.93719113
60Nitrogen metabolism_Homo sapiens_hsa009100.93299881
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.92863808
62Fatty acid elongation_Homo sapiens_hsa000620.90802085
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.90077701
64Gap junction_Homo sapiens_hsa045400.88531943
65Malaria_Homo sapiens_hsa051440.88500157
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87667864
67Ras signaling pathway_Homo sapiens_hsa040140.87439853
68Protein digestion and absorption_Homo sapiens_hsa049740.86420277
69Hematopoietic cell lineage_Homo sapiens_hsa046400.85955241
70Allograft rejection_Homo sapiens_hsa053300.85641447
71Hippo signaling pathway_Homo sapiens_hsa043900.85216125
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.83167964
73Inositol phosphate metabolism_Homo sapiens_hsa005620.82496699
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.82253103
75FoxO signaling pathway_Homo sapiens_hsa040680.82116556
76Phagosome_Homo sapiens_hsa041450.81773178
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80234250
78Cholinergic synapse_Homo sapiens_hsa047250.79226431
79cAMP signaling pathway_Homo sapiens_hsa040240.76881367
80Amphetamine addiction_Homo sapiens_hsa050310.75813559
81Renin secretion_Homo sapiens_hsa049240.75260342
82Cocaine addiction_Homo sapiens_hsa050300.74983004
83Nucleotide excision repair_Homo sapiens_hsa034200.73789816
84Other glycan degradation_Homo sapiens_hsa005110.71897550
85Insulin secretion_Homo sapiens_hsa049110.69818963
86Vitamin digestion and absorption_Homo sapiens_hsa049770.69656849
87Base excision repair_Homo sapiens_hsa034100.67692334
88Renal cell carcinoma_Homo sapiens_hsa052110.67182995
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66115443
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65394783
91Basal transcription factors_Homo sapiens_hsa030220.63588858
92Oxytocin signaling pathway_Homo sapiens_hsa049210.63520588
93African trypanosomiasis_Homo sapiens_hsa051430.63354046
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62951191
95Histidine metabolism_Homo sapiens_hsa003400.61729908
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61187892
97Melanogenesis_Homo sapiens_hsa049160.60934196
98Steroid biosynthesis_Homo sapiens_hsa001000.60741147
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60353644
100Small cell lung cancer_Homo sapiens_hsa052220.60254869
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.59841029
102Hedgehog signaling pathway_Homo sapiens_hsa043400.59533769
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59014180
104Circadian rhythm_Homo sapiens_hsa047100.58858887
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58730219
106Retinol metabolism_Homo sapiens_hsa008300.58617106
107ErbB signaling pathway_Homo sapiens_hsa040120.57840240
108MicroRNAs in cancer_Homo sapiens_hsa052060.57630419
109Dopaminergic synapse_Homo sapiens_hsa047280.56532454
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55275228
111Prolactin signaling pathway_Homo sapiens_hsa049170.55042008
112Oxidative phosphorylation_Homo sapiens_hsa001900.54397467
113MAPK signaling pathway_Homo sapiens_hsa040100.54232989
114Pancreatic cancer_Homo sapiens_hsa052120.54173812
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53414805
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53138029
117Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51285659
118Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51182671
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51011462
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50933976
121beta-Alanine metabolism_Homo sapiens_hsa004100.50876492
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.49739441
123Proteoglycans in cancer_Homo sapiens_hsa052050.49527496
124Dilated cardiomyopathy_Homo sapiens_hsa054140.49386452
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48453982
126Mineral absorption_Homo sapiens_hsa049780.48400217
127Chemokine signaling pathway_Homo sapiens_hsa040620.48131035
128Hepatitis B_Homo sapiens_hsa051610.46352500
129Prostate cancer_Homo sapiens_hsa052150.46300028
130Homologous recombination_Homo sapiens_hsa034400.46257506
131Colorectal cancer_Homo sapiens_hsa052100.45957957
132GnRH signaling pathway_Homo sapiens_hsa049120.45604971
133Bile secretion_Homo sapiens_hsa049760.44465562
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44251325
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42803920
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42707877
137Measles_Homo sapiens_hsa051620.42194267
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41929516
139Osteoclast differentiation_Homo sapiens_hsa043800.41775758
140Pancreatic secretion_Homo sapiens_hsa049720.41454528
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40662034
142Platelet activation_Homo sapiens_hsa046110.40400676
143Chemical carcinogenesis_Homo sapiens_hsa052040.40213926
144mTOR signaling pathway_Homo sapiens_hsa041500.39161012
145Selenocompound metabolism_Homo sapiens_hsa004500.38526617
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38438767
147Choline metabolism in cancer_Homo sapiens_hsa052310.37620921
148RNA transport_Homo sapiens_hsa030130.36290141
149Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33043966
150Maturity onset diabetes of the young_Homo sapiens_hsa049500.32092617

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