PHF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.10617662
2piRNA metabolic process (GO:0034587)4.33872072
3negative regulation of cell killing (GO:0031342)4.19136046
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.19136046
5regulation of ARF protein signal transduction (GO:0032012)4.09460321
6positive thymic T cell selection (GO:0045059)4.01908712
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.98964372
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.98964372
9regulation of gamma-delta T cell differentiation (GO:0045586)3.78123709
10antigen processing and presentation of endogenous antigen (GO:0019883)3.73500779
11regulation of T-helper 2 cell differentiation (GO:0045628)3.71954587
12positive regulation of histone deacetylation (GO:0031065)3.66848550
13positive regulation of gamma-delta T cell activation (GO:0046645)3.64035900
14negative regulation of hormone metabolic process (GO:0032351)3.53486027
15negative regulation of hormone biosynthetic process (GO:0032353)3.53486027
16positive regulation of Rap GTPase activity (GO:0032854)3.46466909
17response to muramyl dipeptide (GO:0032495)3.43847909
18thymic T cell selection (GO:0045061)3.42256040
19tolerance induction (GO:0002507)3.39151838
20cytoplasmic mRNA processing body assembly (GO:0033962)3.32968783
21regulation of gamma-delta T cell activation (GO:0046643)3.28318078
22regulation of meiosis I (GO:0060631)3.26961374
23mannose metabolic process (GO:0006013)3.23291633
24regulation of meiosis (GO:0040020)3.20424657
25growth hormone receptor signaling pathway (GO:0060396)3.14479859
26type B pancreatic cell development (GO:0003323)3.12295239
27male meiosis (GO:0007140)3.06160050
28protein localization to endosome (GO:0036010)3.04451473
29positive T cell selection (GO:0043368)3.03262950
30negative regulation of inclusion body assembly (GO:0090084)3.01010950
31negative regulation of glycoprotein biosynthetic process (GO:0010561)3.00988437
32regulation of glucocorticoid metabolic process (GO:0031943)2.97557194
33leukocyte aggregation (GO:0070486)2.97508067
34histone H3-K36 demethylation (GO:0070544)2.96894959
35regulation of cholesterol homeostasis (GO:2000188)2.95086943
36regulation of female gonad development (GO:2000194)2.93805858
37response to laminar fluid shear stress (GO:0034616)2.89258257
38cellular response to growth hormone stimulus (GO:0071378)2.87795037
39histone H3-K9 demethylation (GO:0033169)2.87354830
40T cell selection (GO:0045058)2.87251776
41signal complex assembly (GO:0007172)2.87159128
42germinal center formation (GO:0002467)2.86903848
43histone H2A monoubiquitination (GO:0035518)2.81729412
44glandular epithelial cell development (GO:0002068)2.81603217
45negative regulation of cAMP-mediated signaling (GO:0043951)2.81118789
46protein targeting to Golgi (GO:0000042)2.79882650
47negative thymic T cell selection (GO:0045060)2.77917328
48regulation of clathrin-mediated endocytosis (GO:2000369)2.74577522
49positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.73974116
50positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.73650926
51regulation of Rap GTPase activity (GO:0032317)2.73344349
52negative T cell selection (GO:0043383)2.73038554
53positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.71540110
54positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.71193694
55establishment of protein localization to Golgi (GO:0072600)2.70169351
56modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.68559866
57positive regulation by organism of defense response of other organism involved in symbiotic interact2.68559866
58modulation by symbiont of host immune response (GO:0052553)2.68559866
59positive regulation by symbiont of host defense response (GO:0052509)2.68559866
60modulation by symbiont of host defense response (GO:0052031)2.68559866
61modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.68559866
62JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.68149444
63response to interleukin-15 (GO:0070672)2.67802109
64positive regulation of granulocyte differentiation (GO:0030854)2.67161354
65phosphatidylglycerol biosynthetic process (GO:0006655)2.66528033
66regulation of cilium assembly (GO:1902017)2.64873510
67phosphatidylethanolamine biosynthetic process (GO:0006646)2.64117611
68macrophage activation involved in immune response (GO:0002281)2.62447150
69histone demethylation (GO:0016577)2.60973639
70negative regulation of erythrocyte differentiation (GO:0045647)2.60069909
71sperm capacitation (GO:0048240)2.59184267
72regulation of Rab GTPase activity (GO:0032313)2.58699406
73positive regulation of Rab GTPase activity (GO:0032851)2.58699406
74sexual reproduction (GO:0019953)2.58176997
75synaptonemal complex assembly (GO:0007130)2.57556808
76detection of bacterium (GO:0016045)2.57315048
77regulation of steroid hormone biosynthetic process (GO:0090030)2.56904571
78negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.56531749
79negative regulation of lymphocyte mediated immunity (GO:0002707)2.56141695
80RNA destabilization (GO:0050779)2.55492248
81histone lysine demethylation (GO:0070076)2.55233339
82negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.54699017
83regulation of interleukin-12 biosynthetic process (GO:0045075)2.53347756
84positive regulation of type 2 immune response (GO:0002830)2.53248800
85gene silencing by RNA (GO:0031047)2.52263660
86histone H3 deacetylation (GO:0070932)2.51968564
87detection of other organism (GO:0098543)2.51092459
88positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.50666428
89synaptonemal complex organization (GO:0070193)2.50378513
90monoubiquitinated protein deubiquitination (GO:0035520)2.49982934
91regulation of meiotic cell cycle (GO:0051445)2.49454014
92positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.47564041
93regulation of B cell receptor signaling pathway (GO:0050855)2.46525061
94negative regulation of leukocyte mediated immunity (GO:0002704)2.45671394
95histone H4 deacetylation (GO:0070933)2.44547625
96macroautophagy (GO:0016236)2.44411543
97regulation of extracellular matrix disassembly (GO:0010715)2.43725443
98negative regulation of viral release from host cell (GO:1902187)2.43443352
99retrograde transport, vesicle recycling within Golgi (GO:0000301)2.43349560
100histone H2A ubiquitination (GO:0033522)2.42396205
101antigen processing and presentation via MHC class Ib (GO:0002475)2.39391019
102negative regulation of granulocyte differentiation (GO:0030853)2.39223275
103acrosome reaction (GO:0007340)2.38704155
104phosphatidylethanolamine metabolic process (GO:0046337)2.38457838
105intracellular estrogen receptor signaling pathway (GO:0030520)2.38356645
106modulation by virus of host process (GO:0019054)2.37974101
107negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.37657338
108positive regulation of CREB transcription factor activity (GO:0032793)2.35433823
109regulation of T cell tolerance induction (GO:0002664)2.35304188
110female gamete generation (GO:0007292)2.34653409
111negative regulation of meiosis (GO:0045835)2.34439864
112cell-cell junction maintenance (GO:0045217)2.32671815
113activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.31415951
114positive regulation of protein deacetylation (GO:0090312)2.31279996
115B cell receptor signaling pathway (GO:0050853)2.30483497
116response to type I interferon (GO:0034340)2.29988666
117modulation by symbiont of host cellular process (GO:0044068)2.29741780
118cellular response to type I interferon (GO:0071357)2.29661966
119type I interferon signaling pathway (GO:0060337)2.29661966
120sodium ion export (GO:0071436)2.28436613
121DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.28254126
122positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.26843985
123regulation of type 2 immune response (GO:0002828)2.26472063
124protein dealkylation (GO:0008214)2.26431514
125protein demethylation (GO:0006482)2.26431514
126negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.26306903
127COPI coating of Golgi vesicle (GO:0048205)2.26160173
128Golgi transport vesicle coating (GO:0048200)2.26160173
129regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.25890999
130positive regulation of extracellular matrix organization (GO:1903055)2.25403025
131adaptation of signaling pathway (GO:0023058)2.25325395
132activation of JUN kinase activity (GO:0007257)2.25124117
133protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.23958075
134NIK/NF-kappaB signaling (GO:0038061)2.23213088
135regulation of inclusion body assembly (GO:0090083)2.22303013
136regulation of RIG-I signaling pathway (GO:0039535)2.21502712
137natural killer cell differentiation (GO:0001779)2.21018422
138negative regulation of toll-like receptor signaling pathway (GO:0034122)2.20541579
139regulation of granulocyte differentiation (GO:0030852)2.20521164
140DNA damage response, signal transduction resulting in transcription (GO:0042772)2.20445107
141meiotic cell cycle (GO:0051321)2.20087943
142negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.19810672
143positive regulation of sodium ion transmembrane transport (GO:1902307)2.19544535
144regulation of Golgi to plasma membrane protein transport (GO:0042996)2.18768750
145regulation of ARF GTPase activity (GO:0032312)2.18227750
146protein targeting to plasma membrane (GO:0072661)2.18186144
147regulation of T cell mediated cytotoxicity (GO:0001914)2.17793943
148regulation of corticosteroid hormone secretion (GO:2000846)2.17635407
149regulation of leukocyte degranulation (GO:0043300)2.16960481
150cellular response to interleukin-15 (GO:0071350)2.16820360
151regulation of tolerance induction (GO:0002643)2.16625004
152diacylglycerol metabolic process (GO:0046339)2.16262792
153negative regulation of T-helper cell differentiation (GO:0045623)2.15008666
154negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.15008666
155regulation of histone deacetylation (GO:0031063)2.14574192
156fusion of sperm to egg plasma membrane (GO:0007342)2.14496720
157regulation of early endosome to late endosome transport (GO:2000641)2.14178223
158negative regulation of innate immune response (GO:0045824)2.13558394
159C21-steroid hormone metabolic process (GO:0008207)2.13148882
160regulation of mast cell degranulation (GO:0043304)2.13013910
161carnitine shuttle (GO:0006853)2.12530334
162multicellular organism reproduction (GO:0032504)2.12480955
163negative regulation of lipid transport (GO:0032369)2.12129151
164negative regulation of meiotic cell cycle (GO:0051447)2.11670091
165response to acidic pH (GO:0010447)2.11535743
166stress granule assembly (GO:0034063)2.10862411
167positive regulation of nuclease activity (GO:0032075)2.10556917
168stress fiber assembly (GO:0043149)2.09758215
169regulation of hippo signaling (GO:0035330)2.09638114
170response to peptidoglycan (GO:0032494)2.09247835
171detection of external biotic stimulus (GO:0098581)2.08896451
172male meiosis I (GO:0007141)2.07752963
173negative regulation of glycoprotein metabolic process (GO:1903019)2.07691683

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.69919708
2MYC_22102868_ChIP-Seq_BL_Human2.60932587
3TCF7_22412390_ChIP-Seq_EML_Mouse2.35826452
4KDM2B_26808549_Chip-Seq_SUP-B15_Human2.33446222
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23433963
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.22445537
7KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.20681081
8KDM2B_26808549_Chip-Seq_DND41_Human2.20033647
9FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.14116048
10E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.04375629
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.98090206
12STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95909137
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.93685692
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91456912
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83548755
16RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83453704
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.82917167
18DROSHA_22980978_ChIP-Seq_HELA_Human1.78951026
19KDM2B_26808549_Chip-Seq_JURKAT_Human1.76404669
20RUNX_20019798_ChIP-Seq_JUKART_Human1.75793671
21KDM2B_26808549_Chip-Seq_K562_Human1.73089182
22UTX_26944678_Chip-Seq_JUKART_Human1.71180035
23SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.60656497
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.59611716
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57868480
26VDR_21846776_ChIP-Seq_THP-1_Human1.55438873
27* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55385640
28ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52605928
29MAF_26560356_Chip-Seq_TH1_Human1.47765399
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47376901
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.46974263
32CTCF_27219007_Chip-Seq_Bcells_Human1.46781695
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.46361563
34LXR_22158963_ChIP-Seq_LIVER_Mouse1.45862994
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.44475983
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.43464155
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.43096149
38RUNX1_27514584_Chip-Seq_MCF-7_Human1.41746452
39PPARA_22158963_ChIP-Seq_LIVER_Mouse1.38977169
40BCL6_27268052_Chip-Seq_Bcells_Human1.36751782
41DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.34443155
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.32999091
43LXR_22292898_ChIP-Seq_THP-1_Human1.31461383
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.30285988
45SMC4_20622854_ChIP-Seq_HELA_Human1.30155859
46* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29228630
47GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28410750
48GATA1_19941826_ChIP-Seq_K562_Human1.27864998
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.26380410
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25850189
51P68_20966046_ChIP-Seq_HELA_Human1.25597581
52GATA3_27048872_Chip-Seq_THYMUS_Human1.25035325
53UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24960871
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24076515
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.23195991
56SPI1_23127762_ChIP-Seq_K562_Human1.22476666
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22344370
58* MYB_26560356_Chip-Seq_TH1_Human1.21757437
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.21658058
60FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20942249
61* MYB_26560356_Chip-Seq_TH2_Human1.20549501
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19327434
63FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18743658
64ELK4_26923725_Chip-Seq_MESODERM_Mouse1.18087942
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.17432964
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17287992
67RACK7_27058665_Chip-Seq_MCF-7_Human1.16680920
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16469796
69TBX20_22080862_ChIP-Seq_HEART_Mouse1.16055826
70TBX20_22328084_ChIP-Seq_HEART_Mouse1.16055826
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15814137
72EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13919490
73SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12967612
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11549684
75CREB1_26743006_Chip-Seq_LNCaP_Human1.11388464
76SA1_27219007_Chip-Seq_Bcells_Human1.11081940
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09778032
78TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09718976
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08257063
80SCL_19346495_ChIP-Seq_HPC-7_Human1.08101409
81FOXA2_19822575_ChIP-Seq_HepG2_Human1.07869689
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.07474578
83CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07366533
84E2F1_20622854_ChIP-Seq_HELA_Human1.06952001
85MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06852039
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06834381
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06619231
88PHF8_20622854_ChIP-Seq_HELA_Human1.05824128
89FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.05557651
90NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05256332
91SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04598538
92SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04546002
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03784129
94IRF8_27001747_Chip-Seq_BMDM_Mouse1.03492674
95* OCT4_19829295_ChIP-Seq_ESCs_Human1.02846710
96VDR_24763502_ChIP-Seq_THP-1_Human1.01835614
97TP63_22573176_ChIP-Seq_HFKS_Human1.01627882
98MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01363440
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00892613
100* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99754357
101SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99036249
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99014569
103PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98924218
104ZNF263_19887448_ChIP-Seq_K562_Human0.98887488
105RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98799339
106CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98669495
107MAF_26560356_Chip-Seq_TH2_Human0.98454407
108RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98147858
109DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98139454
110GATA2_19941826_ChIP-Seq_K562_Human0.98003356
111ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97451325
112ELF1_20517297_ChIP-Seq_JURKAT_Human0.97294557
113MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97200525
114NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96746862
115ATF3_27146783_Chip-Seq_COLON_Human0.95682950
116* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95646993
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95482179
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94597260
119* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94185406
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93428729
121TET1_21490601_ChIP-Seq_MESCs_Mouse0.93247966
122BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92893490
123GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92520371
124GATA1_26923725_Chip-Seq_HPCs_Mouse0.92364974
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91934117
126NCOR1_26117541_ChIP-Seq_K562_Human0.91747005
127MYC_27129775_Chip-Seq_CORNEA_Mouse0.91589524
128ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90791121
129GATA2_21666600_ChIP-Seq_HMVEC_Human0.90034227
130BCOR_27268052_Chip-Seq_Bcells_Human0.89943772
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89438649
132RARB_27405468_Chip-Seq_BRAIN_Mouse0.88696982
133CTCF_21964334_Chip-Seq_Bcells_Human0.88154680
134STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.87438590
135RUNX1_22412390_ChIP-Seq_EML_Mouse0.86712419
136SA1_27219007_Chip-Seq_ERYTHROID_Human0.86348302

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.63853564
2MP0008961_abnormal_basal_metabolism3.44808333
3MP0005451_abnormal_body_composition3.16113427
4MP0002653_abnormal_ependyma_morphology3.00209154
5MP0003172_abnormal_lysosome_physiology2.98149701
6MP0004510_myositis2.62308163
7MP0003300_gastrointestinal_ulcer2.56889845
8MP0003763_abnormal_thymus_physiology2.47124493
9MP0001348_abnormal_lacrimal_gland2.43826308
10MP0003724_increased_susceptibility_to2.43011030
11MP0002909_abnormal_adrenal_gland2.40952922
12MP0004185_abnormal_adipocyte_glucose2.40051786
13MP0003303_peritoneal_inflammation2.13055370
14MP0010234_abnormal_vibrissa_follicle2.04979580
15MP0009840_abnormal_foam_cell2.03643197
16MP0000685_abnormal_immune_system2.00584016
17MP0005365_abnormal_bile_salt1.97173884
18MP0005310_abnormal_salivary_gland1.97087536
19MP0002877_abnormal_melanocyte_morpholog1.90780607
20MP0009278_abnormal_bone_marrow1.89805957
21MP0002419_abnormal_innate_immunity1.87823673
22MP0008260_abnormal_autophagy1.82469526
23MP0005670_abnormal_white_adipose1.80122331
24MP0005025_abnormal_response_to1.76171591
25MP0001533_abnormal_skeleton_physiology1.74970057
26MP0002933_joint_inflammation1.74470756
27MP0003045_fibrosis1.72282294
28MP0003252_abnormal_bile_duct1.68970255
29MP0001790_abnormal_immune_system1.67839578
30MP0005387_immune_system_phenotype1.67839578
31MP0003279_aneurysm1.66494178
32MP0002837_dystrophic_cardiac_calcinosis1.65237420
33MP0002139_abnormal_hepatobiliary_system1.61819435
34MP0001800_abnormal_humoral_immune1.59818241
35MP0001835_abnormal_antigen_presentation1.59292466
36MP0005377_hearing/vestibular/ear_phenot1.58538774
37MP0003878_abnormal_ear_physiology1.58538774
38MP0002132_abnormal_respiratory_system1.56028093
39MP0002998_abnormal_bone_remodeling1.54015590
40MP0004130_abnormal_muscle_cell1.50075404
41MP0005410_abnormal_fertilization1.48707282
42MP0005666_abnormal_adipose_tissue1.48029053
43MP0005360_urolithiasis1.47509596
44MP0002928_abnormal_bile_duct1.46228404
45MP0000678_abnormal_parathyroid_gland1.45507137
46MP0003191_abnormal_cellular_cholesterol1.42257940
47MP0009333_abnormal_splenocyte_physiolog1.41090874
48MP0001765_abnormal_ion_homeostasis1.40782775
49MP0010368_abnormal_lymphatic_system1.40606808
50MP0003828_pulmonary_edema1.40390280
51MP0001944_abnormal_pancreas_morphology1.40066149
52MP0003879_abnormal_hair_cell1.39481411
53MP0002693_abnormal_pancreas_physiology1.38372191
54MP0001501_abnormal_sleep_pattern1.34016911
55MP0000639_abnormal_adrenal_gland1.33128066
56MP0000003_abnormal_adipose_tissue1.31614188
57MP0005375_adipose_tissue_phenotype1.31046191
58MP0002138_abnormal_hepatobiliary_system1.30461015
59MP0003699_abnormal_female_reproductive1.29858094
60MP0003705_abnormal_hypodermis_morpholog1.29710193
61MP0001929_abnormal_gametogenesis1.29004936
62MP0001873_stomach_inflammation1.28967615
63MP0005397_hematopoietic_system_phenotyp1.26472439
64MP0001545_abnormal_hematopoietic_system1.26472439
65MP0005423_abnormal_somatic_nervous1.26250879
66MP0004858_abnormal_nervous_system1.25862510
67MP0000609_abnormal_liver_physiology1.24895430
68MP0009785_altered_susceptibility_to1.24304450
69MP0002168_other_aberrant_phenotype1.23955237
70MP0003329_amyloid_beta_deposits1.22271253
71MP0008569_lethality_at_weaning1.20960616
72MP0001958_emphysema1.18245195
73MP0001851_eye_inflammation1.17910641
74MP0003075_altered_response_to1.17132520
75MP0003690_abnormal_glial_cell1.15083324
76MP0002398_abnormal_bone_marrow1.14981714
77MP0001853_heart_inflammation1.13406014
78MP0001849_ear_inflammation1.12571349
79MP0005464_abnormal_platelet_physiology1.11450307
80MP0006082_CNS_inflammation1.10139856
81MP0002078_abnormal_glucose_homeostasis1.09658148
82MP0002723_abnormal_immune_serum1.09442652
83MP0004947_skin_inflammation1.08736779
84MP0000013_abnormal_adipose_tissue1.08683298
85MP0002405_respiratory_system_inflammati1.08505259
86MP0005671_abnormal_response_to1.05852405
87MP0000249_abnormal_blood_vessel1.03351014
88MP0002822_catalepsy1.02434853
89MP0004264_abnormal_extraembryonic_tissu1.01754113
90MP0002420_abnormal_adaptive_immunity1.01443976
91MP0002452_abnormal_antigen_presenting1.00659681
92MP0003866_abnormal_defecation1.00520157
93MP0004036_abnormal_muscle_relaxation0.98313201
94MP0001819_abnormal_immune_cell0.98236817
95MP0005409_darkened_coat_color0.98010748
96MP0002971_abnormal_brown_adipose0.96927364
97MP0000716_abnormal_immune_system0.96890403
98MP0003183_abnormal_peptide_metabolism0.95564562
99MP0005390_skeleton_phenotype0.95413757
100MP0010329_abnormal_lipoprotein_level0.94915212
101MP0000689_abnormal_spleen_morphology0.94817685
102MP0001502_abnormal_circadian_rhythm0.93555510
103MP0002429_abnormal_blood_cell0.93222773
104MP0005076_abnormal_cell_differentiation0.91833654
105MP0001845_abnormal_inflammatory_respons0.91761405
106MP0004381_abnormal_hair_follicle0.90840883
107MP0002148_abnormal_hypersensitivity_rea0.90572640
108MP0003091_abnormal_cell_migration0.89968439
109MP0009643_abnormal_urine_homeostasis0.89733855
110MP0009764_decreased_sensitivity_to0.89295995
111MP0005166_decreased_susceptibility_to0.88236091
112MP0005000_abnormal_immune_tolerance0.88087118
113MP0000751_myopathy0.87355024
114MP0004808_abnormal_hematopoietic_stem0.87119439
115MP0000703_abnormal_thymus_morphology0.86849585
116MP0008874_decreased_physiological_sensi0.85472941
117MP0008877_abnormal_DNA_methylation0.84715359
118MP0001119_abnormal_female_reproductive0.84524301
119MP0005395_other_phenotype0.84300356
120MP0003635_abnormal_synaptic_transmissio0.84125897
121MP0002118_abnormal_lipid_homeostasis0.84017013
122MP0004859_abnormal_synaptic_plasticity0.82946426
123MP0002161_abnormal_fertility/fecundity0.82895814
124MP0000653_abnormal_sex_gland0.82657286
125MP0000858_altered_metastatic_potential0.81772005
126MP0005058_abnormal_lysosome_morphology0.80652142
127MP0008875_abnormal_xenobiotic_pharmacok0.80358261
128MP0000604_amyloidosis0.80276913
129MP0003436_decreased_susceptibility_to0.79977129
130MP0002136_abnormal_kidney_physiology0.79330896
131MP0010155_abnormal_intestine_physiology0.79224160
132MP0003453_abnormal_keratinocyte_physiol0.79186327
133MP0002269_muscular_atrophy0.78207898
134MP0005220_abnormal_exocrine_pancreas0.77900695
135MP0000920_abnormal_myelination0.77608267
136MP0008469_abnormal_protein_level0.77324482
137MP0002249_abnormal_larynx_morphology0.77102807
138MP0003868_abnormal_feces_composition0.74827871
139MP0002722_abnormal_immune_system0.74410303
140MP0005535_abnormal_body_temperature0.74267628
141MP0002970_abnormal_white_adipose0.74059551
142MP0003566_abnormal_cell_adhesion0.74024115
143MP0005085_abnormal_gallbladder_physiolo0.72511095
144MP0009115_abnormal_fat_cell0.71526412
145MP0002063_abnormal_learning/memory/cond0.69981415

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)4.67654285
2Nasal polyposis (HP:0100582)4.49246179
3Abnormality of the nasal mucosa (HP:0000433)4.42642154
4Abnormality of the fingertips (HP:0001211)4.04646108
5Eczematoid dermatitis (HP:0000976)3.98366107
6Obstructive sleep apnea (HP:0002870)3.95443533
7Polycythemia (HP:0001901)3.41165044
8Cerebral aneurysm (HP:0004944)3.14677715
9Long toe (HP:0010511)3.10293419
10Infertility (HP:0000789)3.09118024
11Supranuclear gaze palsy (HP:0000605)3.01558230
12Chronic bronchitis (HP:0004469)3.00747051
13Myositis (HP:0100614)2.93944207
14Abnormality of macrophages (HP:0004311)2.92660402
15Arterial tortuosity (HP:0005116)2.87853528
16Bronchitis (HP:0012387)2.86483579
17Aortic aneurysm (HP:0004942)2.85778304
18Colitis (HP:0002583)2.84557455
19Striae distensae (HP:0001065)2.77266946
20Recurrent bronchitis (HP:0002837)2.76974598
21Bundle branch block (HP:0011710)2.72697276
22Aneurysm (HP:0002617)2.72546877
23Neurofibrillary tangles (HP:0002185)2.70451701
24Broad face (HP:0000283)2.65755092
25Asymmetric septal hypertrophy (HP:0001670)2.57265062
26Hyperacusis (HP:0010780)2.55720183
27Fatigue (HP:0012378)2.54499251
28Deep venous thrombosis (HP:0002625)2.54453723
29Abnormality of binocular vision (HP:0011514)2.53987013
30Diplopia (HP:0000651)2.53987013
31Cellulitis (HP:0100658)2.53869934
32Orchitis (HP:0100796)2.53118917
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.51382488
34Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.50597119
35Peripheral hypomyelination (HP:0007182)2.50141026
36Vascular tortuosity (HP:0004948)2.47164854
37Recurrent bacterial skin infections (HP:0005406)2.46514386
38Insulin-resistant diabetes mellitus (HP:0000831)2.45001748
39Segmental peripheral demyelination/remyelination (HP:0003481)2.42696018
40Gastrointestinal inflammation (HP:0004386)2.41571129
41Increased IgE level (HP:0003212)2.41492583
42Gingivitis (HP:0000230)2.41366154
43Recurrent abscess formation (HP:0002722)2.39493142
44Inflammation of the large intestine (HP:0002037)2.38739091
45Abnormal delayed hypersensitivity skin test (HP:0002963)2.37849098
46Slow saccadic eye movements (HP:0000514)2.35554723
47Gastrointestinal stroma tumor (HP:0100723)2.33670562
48Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.31262212
49Chronic obstructive pulmonary disease (HP:0006510)2.28833811
50Obstructive lung disease (HP:0006536)2.28833811
51Bronchiectasis (HP:0002110)2.26088447
52Spondylolisthesis (HP:0003302)2.24574456
53Autoimmune thrombocytopenia (HP:0001973)2.23126252
54Myocardial infarction (HP:0001658)2.21565311
55Elevated erythrocyte sedimentation rate (HP:0003565)2.21559801
56Cerebral inclusion bodies (HP:0100314)2.21221038
57Hematochezia (HP:0002573)2.18986113
58Mediastinal lymphadenopathy (HP:0100721)2.17785736
59Thin bony cortex (HP:0002753)2.16150647
60Severe visual impairment (HP:0001141)2.15925252
61Recurrent otitis media (HP:0000403)2.14078551
62Vasculitis (HP:0002633)2.13778305
63Optic neuritis (HP:0100653)2.13686215
64Retrobulbar optic neuritis (HP:0100654)2.13686215
65Hyperglycemia (HP:0003074)2.13031607
66Emphysema (HP:0002097)2.11017934
67Atrioventricular block (HP:0001678)2.10578143
68Enlarged penis (HP:0000040)2.10247640
69Ankle clonus (HP:0011448)2.09820118
70Deep palmar crease (HP:0006191)2.09695053
71Papillary thyroid carcinoma (HP:0002895)2.09355942
72Meningitis (HP:0001287)2.08029015
73Easy fatigability (HP:0003388)2.07970877
74Sensorimotor neuropathy (HP:0007141)2.07903904
75Prolonged bleeding time (HP:0003010)2.05781148
76Gout (HP:0001997)2.05630829
77Recurrent gram-negative bacterial infections (HP:0005420)2.03764235
78EMG: neuropathic changes (HP:0003445)2.01374180
79Heterotopia (HP:0002282)2.01172559
80Abnormality of small intestinal villus morphology (HP:0011472)2.00105442
81Villous atrophy (HP:0011473)2.00105442
82Pustule (HP:0200039)1.99858853
83Late onset (HP:0003584)1.97409265
84Ketoacidosis (HP:0001993)1.95421026
85Chronic otitis media (HP:0000389)1.94357644
86Mitral valve prolapse (HP:0001634)1.93669658
87Annular pancreas (HP:0001734)1.92908201
88Stomatitis (HP:0010280)1.92896798
89Onion bulb formation (HP:0003383)1.92102274
90Heart block (HP:0012722)1.91524211
91Abnormality of the lower motor neuron (HP:0002366)1.90340342
92Hypochromic anemia (HP:0001931)1.89608416
93Chest pain (HP:0100749)1.88655943
94Aortic dissection (HP:0002647)1.88223062
95Growth hormone excess (HP:0000845)1.87703809
96Recurrent fungal infections (HP:0002841)1.86098057
97Ventricular fibrillation (HP:0001663)1.84963932
98Hemorrhage of the eye (HP:0011885)1.84639659
99Camptodactyly of toe (HP:0001836)1.84426608
100Interstitial pulmonary disease (HP:0006530)1.83615359
101Agammaglobulinemia (HP:0004432)1.83522958
102Atelectasis (HP:0100750)1.82241801
103Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81891395
104Abnormality of polysaccharide metabolism (HP:0011012)1.81891395
105Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81891395
106Increased CSF protein (HP:0002922)1.80988449
107Pulmonary infiltrates (HP:0002113)1.80925603
108Abnormality of the aortic arch (HP:0012303)1.80859605
109Restrictive lung disease (HP:0002091)1.79958664
110Stridor (HP:0010307)1.79150030
111Insulin resistance (HP:0000855)1.77881524
112Mucopolysacchariduria (HP:0008155)1.77544358
113Urinary glycosaminoglycan excretion (HP:0003541)1.77544358
114Gastrointestinal infarctions (HP:0005244)1.76900871
115Rapidly progressive (HP:0003678)1.76837509
116Verrucae (HP:0200043)1.75580916
117Papilloma (HP:0012740)1.75580916
118Arterial thrombosis (HP:0004420)1.74782907
119Macroorchidism (HP:0000053)1.74667254
120Hypertriglyceridemia (HP:0002155)1.74490190
121Dysmetric saccades (HP:0000641)1.74325099
122Complement deficiency (HP:0004431)1.73498449
123Spontaneous hematomas (HP:0007420)1.73383469
124Cubitus valgus (HP:0002967)1.72907789
125Abnormal atrioventricular conduction (HP:0005150)1.72852773
126Cervical subluxation (HP:0003308)1.72650684
127Turricephaly (HP:0000262)1.72514703
128Ketosis (HP:0001946)1.72309854
129Anosmia (HP:0000458)1.71100435
130Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.69501421
131Distal lower limb amyotrophy (HP:0008944)1.68574724
132Papilledema (HP:0001085)1.67915064
133Epistaxis (HP:0000421)1.67861219
134Hand muscle atrophy (HP:0009130)1.67821368
135Global brain atrophy (HP:0002283)1.67787578
136Episodic fever (HP:0001954)1.67511730
137Metaphyseal cupping (HP:0003021)1.66623443
138Abnormality of calcium-phosphate metabolism (HP:0100530)1.66340941
139Peritonitis (HP:0002586)1.65473916
140Shawl scrotum (HP:0000049)1.65379633
141Recurrent sinusitis (HP:0011108)1.65171940
142Hypercortisolism (HP:0001578)1.63974997
143Dysostosis multiplex (HP:0000943)1.63310171
144Stereotypic behavior (HP:0000733)1.63188722
145Hemiplegia (HP:0002301)1.63092256
146Abnormality of endocrine pancreas physiology (HP:0012093)1.62786988
147Abnormality of the pancreatic islet cells (HP:0006476)1.62786988
148Acne (HP:0001061)1.62680760
149Increased connective tissue (HP:0009025)1.62642423
150Distal upper limb amyotrophy (HP:0007149)1.61527102
151Upper limb amyotrophy (HP:0009129)1.61527102
152Recurrent skin infections (HP:0001581)1.60911310
153Increased variability in muscle fiber diameter (HP:0003557)1.60885977
154Neuronal loss in central nervous system (HP:0002529)1.60865842
155Amyloidosis (HP:0011034)1.60603780
156Narrow palate (HP:0000189)1.60597312
157Polygenic inheritance (HP:0010982)1.60272344
158Decreased motor nerve conduction velocity (HP:0003431)1.60170420
159Spinal canal stenosis (HP:0003416)1.59808705
160Neoplasm of the heart (HP:0100544)1.58929707
161Protrusio acetabuli (HP:0003179)1.58152634
162Difficulty running (HP:0009046)1.57670428
163T lymphocytopenia (HP:0005403)1.56334549
164Precocious puberty (HP:0000826)1.55125552
165Postural instability (HP:0002172)1.53876934
166Loss of speech (HP:0002371)1.53773678
167Panhypogammaglobulinemia (HP:0003139)1.53558285
168Hyperkalemia (HP:0002153)1.53484971
169Exercise-induced myalgia (HP:0003738)1.53377198
170Sandal gap (HP:0001852)1.53216103
171Lip pit (HP:0100267)1.52830555

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KSR23.16318355
2TAOK13.12637286
3PRPF4B3.08195748
4TAOK33.07977121
5EEF2K2.95902786
6TRIB32.95108059
7MAP3K132.82556444
8MAP3K92.72971983
9LATS12.56664464
10PRKD32.48505925
11RIPK42.47253755
12MAP4K12.33941207
13ERN12.22228457
14LATS22.00375161
15MAP3K61.89087289
16PRKD21.82858589
17STK381.75099264
18TESK11.72608420
19MOS1.66252508
20MAPKAPK31.63173326
21SIK31.53260484
22TNK21.50979785
23BLK1.49711157
24DDR21.49528083
25MARK21.48693666
26MAP2K31.48030953
27PAK61.42643219
28HIPK21.40235048
29RAF11.36757668
30PKN21.35260361
31IRAK41.34493931
32JAK31.30384033
33UHMK11.27871058
34JAK11.27160703
35PRKCH1.26494309
36STK101.25952133
37MAP3K101.25155308
38TYK21.24958968
39FGFR41.22678586
40CDC42BPA1.21877131
41MAP3K111.21618209
42RET1.21426456
43MAPK151.18751665
44DMPK1.17843810
45TYRO31.13828291
46FES1.11605759
47RIPK11.11587972
48STK38L1.10657625
49MAP3K11.10041575
50MAP3K31.00444333
51SIK11.00368460
52BRD40.99861149
53JAK20.98361760
54TGFBR20.97562711
55MAP3K140.96178390
56CDK90.95629031
57TXK0.94948580
58ZAP700.94501166
59SMG10.93971962
60SIK20.91849260
61ERBB40.90933943
62MAP3K70.89951535
63RPS6KA20.88664781
64GRK60.87709836
65TTN0.87707486
66ITK0.83748676
67IRAK30.83426002
68ICK0.83170778
69MUSK0.82600908
70PDGFRA0.82538349
71NLK0.80382802
72EPHB10.78976474
73CAMK1G0.77947546
74SGK30.76443489
75RPS6KC10.74865435
76RPS6KL10.74865435
77STK30.73336137
78PDGFRB0.72875725
79PDK10.72249931
80ARAF0.72235071
81FGFR30.72137470
82MAP2K20.71106131
83SYK0.70617503
84NEK20.70568118
85PRKAA10.70458175
86MAPK70.70094695
87BMX0.69808115
88PTK20.68728964
89TAOK20.68078252
90PRKAA20.65824414
91MAP3K20.65282019
92CAMKK10.65278280
93PTK60.65265657
94KSR10.63904740
95NTRK30.63816282
96MELK0.63357792
97IKBKE0.63029934
98PDK30.61532747
99PDK40.61532747
100RPS6KA60.59478732
101IKBKB0.59140090
102MAPK110.59066277
103IRAK20.58466967
104CAMK1D0.58179882
105PDPK10.57851305
106BMPR20.57203842
107LCK0.56577871
108HCK0.56059632
109CSK0.55057946
110EPHA30.53930057
111WNK40.53195149
112MAPK40.53051887
113PINK10.52644125
114LRRK20.52354630
115STK110.51871544
116SGK2230.51028546
117SGK4940.51028546
118PRKD10.50707594
119CAMK40.50314637
120NTRK20.47682665
121MARK30.47239510
122CHUK0.47188763
123CDK120.46748157
124MTOR0.46107682
125RPS6KA10.45742587
126TBK10.45347746
127INSRR0.45245414
128MAP3K40.44973848
129CAMK10.44695922
130PTK2B0.44677708
131SGK20.44271440
132MAP2K60.43749022
133MAP2K40.43446285
134BTK0.41898286
135LMTK20.40548670
136NTRK10.40209469
137PAK30.40029281
138WNK10.35939495
139DYRK1B0.35288484
140MAPK120.35222252
141BRAF0.32349264

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043201.97734202
2Circadian rhythm_Homo sapiens_hsa047101.71100273
3B cell receptor signaling pathway_Homo sapiens_hsa046621.67956883
4Pancreatic cancer_Homo sapiens_hsa052121.61693227
5Prolactin signaling pathway_Homo sapiens_hsa049171.59426602
6VEGF signaling pathway_Homo sapiens_hsa043701.55161715
7Ovarian steroidogenesis_Homo sapiens_hsa049131.53179112
8Maturity onset diabetes of the young_Homo sapiens_hsa049501.52580081
9Leishmaniasis_Homo sapiens_hsa051401.50508024
10Allograft rejection_Homo sapiens_hsa053301.44784828
11Type II diabetes mellitus_Homo sapiens_hsa049301.43600044
12mTOR signaling pathway_Homo sapiens_hsa041501.41540842
13Insulin resistance_Homo sapiens_hsa049311.41224944
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41049319
15Autoimmune thyroid disease_Homo sapiens_hsa053201.41020812
16Graft-versus-host disease_Homo sapiens_hsa053321.39098854
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37150866
18GnRH signaling pathway_Homo sapiens_hsa049121.34893348
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.34386437
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31845621
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25011303
22T cell receptor signaling pathway_Homo sapiens_hsa046601.24757863
23Primary immunodeficiency_Homo sapiens_hsa053401.24477036
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24146595
25Chronic myeloid leukemia_Homo sapiens_hsa052201.21218648
26Estrogen signaling pathway_Homo sapiens_hsa049151.19811625
27Longevity regulating pathway - mammal_Homo sapiens_hsa042111.18169817
28Type I diabetes mellitus_Homo sapiens_hsa049401.16793125
29Insulin secretion_Homo sapiens_hsa049111.16643055
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14093389
31Lysine degradation_Homo sapiens_hsa003101.13267929
32Nitrogen metabolism_Homo sapiens_hsa009101.11952931
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09863189
34Osteoclast differentiation_Homo sapiens_hsa043801.09134412
35Tuberculosis_Homo sapiens_hsa051521.07754867
36Choline metabolism in cancer_Homo sapiens_hsa052311.06705507
37Influenza A_Homo sapiens_hsa051641.06394805
38Non-small cell lung cancer_Homo sapiens_hsa052231.04266015
39Glucagon signaling pathway_Homo sapiens_hsa049221.03678014
40Acute myeloid leukemia_Homo sapiens_hsa052211.02308450
41Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01063551
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00064581
43Endometrial cancer_Homo sapiens_hsa052130.99601637
44Inositol phosphate metabolism_Homo sapiens_hsa005620.97369565
45Renal cell carcinoma_Homo sapiens_hsa052110.97118793
46Neurotrophin signaling pathway_Homo sapiens_hsa047220.96456316
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.95887898
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.94774010
49Viral myocarditis_Homo sapiens_hsa054160.93646765
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.92686135
51Colorectal cancer_Homo sapiens_hsa052100.92405672
52Insulin signaling pathway_Homo sapiens_hsa049100.91500164
53Measles_Homo sapiens_hsa051620.90362535
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90252803
55Platelet activation_Homo sapiens_hsa046110.89214799
56Notch signaling pathway_Homo sapiens_hsa043300.89091727
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88492586
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87537117
59Prion diseases_Homo sapiens_hsa050200.86021204
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85681268
61Chemokine signaling pathway_Homo sapiens_hsa040620.85557450
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.84799606
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84071373
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83506937
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82713199
66Malaria_Homo sapiens_hsa051440.82609965
67ABC transporters_Homo sapiens_hsa020100.82377538
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81788559
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.81621128
70Long-term potentiation_Homo sapiens_hsa047200.81486759
71AMPK signaling pathway_Homo sapiens_hsa041520.80362682
72Bile secretion_Homo sapiens_hsa049760.79935809
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.79552764
74MAPK signaling pathway_Homo sapiens_hsa040100.78891139
75FoxO signaling pathway_Homo sapiens_hsa040680.78535338
76Toxoplasmosis_Homo sapiens_hsa051450.78220304
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78035237
78Antigen processing and presentation_Homo sapiens_hsa046120.77045451
79Glycerolipid metabolism_Homo sapiens_hsa005610.76920911
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.76810516
81Endocytosis_Homo sapiens_hsa041440.76355505
82Hepatitis C_Homo sapiens_hsa051600.76212544
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75992858
84Cocaine addiction_Homo sapiens_hsa050300.75878872
85Synaptic vesicle cycle_Homo sapiens_hsa047210.75835444
86cAMP signaling pathway_Homo sapiens_hsa040240.74514057
87Other glycan degradation_Homo sapiens_hsa005110.74432328
88Gastric acid secretion_Homo sapiens_hsa049710.73632579
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.73233825
90Herpes simplex infection_Homo sapiens_hsa051680.72946999
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72900853
92Glioma_Homo sapiens_hsa052140.72745248
93Oxytocin signaling pathway_Homo sapiens_hsa049210.68268040
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68214934
95Pancreatic secretion_Homo sapiens_hsa049720.67150819
96Pertussis_Homo sapiens_hsa051330.66511103
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66434827
98Hematopoietic cell lineage_Homo sapiens_hsa046400.66338560
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65654400
100Renin secretion_Homo sapiens_hsa049240.65367664
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65313137
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65250978
103TNF signaling pathway_Homo sapiens_hsa046680.64682908
104Apoptosis_Homo sapiens_hsa042100.64156011
105Cholinergic synapse_Homo sapiens_hsa047250.63532454
106Amphetamine addiction_Homo sapiens_hsa050310.63192997
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62844308
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62266378
109Hepatitis B_Homo sapiens_hsa051610.61794749
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61479800
111Prostate cancer_Homo sapiens_hsa052150.60896671
112Arginine biosynthesis_Homo sapiens_hsa002200.60753007
113PPAR signaling pathway_Homo sapiens_hsa033200.60713211
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59777473
115Adherens junction_Homo sapiens_hsa045200.59541629
116Morphine addiction_Homo sapiens_hsa050320.58863940
117HIF-1 signaling pathway_Homo sapiens_hsa040660.58502211
118Thyroid hormone synthesis_Homo sapiens_hsa049180.58402623
119Amoebiasis_Homo sapiens_hsa051460.58357681
120Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57744123
121ErbB signaling pathway_Homo sapiens_hsa040120.57704542
122Fatty acid degradation_Homo sapiens_hsa000710.57419859
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.56690343
124Bladder cancer_Homo sapiens_hsa052190.56454133
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56448256
126Phagosome_Homo sapiens_hsa041450.56361495
127Ras signaling pathway_Homo sapiens_hsa040140.56306363
128Salivary secretion_Homo sapiens_hsa049700.54623876
129Olfactory transduction_Homo sapiens_hsa047400.54477208
130Rap1 signaling pathway_Homo sapiens_hsa040150.54033837
131Staphylococcus aureus infection_Homo sapiens_hsa051500.48488753
132Small cell lung cancer_Homo sapiens_hsa052220.47638494
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.45496924
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45453390
135NF-kappa B signaling pathway_Homo sapiens_hsa040640.45353953

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