PHF11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing a PHD (plant homeodomain) type zinc finger. This gene has been identified in some studies as a candidate gene for asthma. Naturally-occurring readthrough transcription may occur from the upstream SETDB2 (SET domain bifurcated 2) gene to this locus. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.20923956
2negative regulation of cell killing (GO:0031342)4.83299193
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.83299193
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.82681639
5antigen processing and presentation of endogenous antigen (GO:0019883)4.45842407
6type I interferon signaling pathway (GO:0060337)4.45510087
7cellular response to type I interferon (GO:0071357)4.45510087
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.43457652
9regulation of B cell receptor signaling pathway (GO:0050855)4.42942609
10response to type I interferon (GO:0034340)4.41532970
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.30587489
12immunoglobulin mediated immune response (GO:0016064)4.26929960
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.16182558
14negative regulation of interleukin-12 production (GO:0032695)4.10578747
15regulation of gamma-delta T cell activation (GO:0046643)4.02310141
16T cell migration (GO:0072678)3.93880629
17interferon-gamma-mediated signaling pathway (GO:0060333)3.90358387
18negative thymic T cell selection (GO:0045060)3.71671642
19negative T cell selection (GO:0043383)3.68109776
20regulation of gamma-delta T cell differentiation (GO:0045586)3.63701488
21positive thymic T cell selection (GO:0045059)3.60014916
22neutrophil activation involved in immune response (GO:0002283)3.58131668
23positive regulation by symbiont of host defense response (GO:0052509)3.57690421
24modulation by symbiont of host defense response (GO:0052031)3.57690421
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.57690421
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.57690421
27positive regulation by organism of defense response of other organism involved in symbiotic interact3.57690421
28modulation by symbiont of host immune response (GO:0052553)3.57690421
29negative regulation of T cell mediated immunity (GO:0002710)3.50510818
30positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.47928686
31regulation of T cell tolerance induction (GO:0002664)3.47519486
32response to peptidoglycan (GO:0032494)3.47200597
33response to interferon-beta (GO:0035456)3.44383511
34leukocyte aggregation (GO:0070486)3.44138918
35regulation of dendritic cell antigen processing and presentation (GO:0002604)3.43997291
36macrophage activation involved in immune response (GO:0002281)3.42209374
37cellular response to interleukin-15 (GO:0071350)3.41663391
38response to interleukin-15 (GO:0070672)3.41637712
39detection of other organism (GO:0098543)3.40952525
40defense response to protozoan (GO:0042832)3.40598930
41regulation of interferon-alpha production (GO:0032647)3.39444130
42regulation of alpha-beta T cell proliferation (GO:0046640)3.38202873
43B cell mediated immunity (GO:0019724)3.35650888
44detection of bacterium (GO:0016045)3.35596839
45positive regulation of antigen processing and presentation (GO:0002579)3.25387351
46regulation of tolerance induction (GO:0002643)3.25285916
47regulation of antigen processing and presentation (GO:0002577)3.24351553
48positive regulation of interferon-alpha production (GO:0032727)3.24280059
49positive T cell selection (GO:0043368)3.23867239
50negative regulation of viral genome replication (GO:0045071)3.23696402
51response to interferon-alpha (GO:0035455)3.22913356
52negative regulation of lymphocyte mediated immunity (GO:0002707)3.21414841
53regulation of T cell mediated cytotoxicity (GO:0001914)3.21001777
54regulation of T-helper 1 cell differentiation (GO:0045625)3.17413521
55response to protozoan (GO:0001562)3.16271405
56regulation of regulatory T cell differentiation (GO:0045589)3.15487841
57positive regulation of tolerance induction (GO:0002645)3.12342146
58T cell selection (GO:0045058)3.10181092
59positive regulation of T cell mediated cytotoxicity (GO:0001916)3.09406773
60interferon-gamma production (GO:0032609)3.06834693
61regulation of interferon-beta biosynthetic process (GO:0045357)3.06690799
62positive regulation of alpha-beta T cell proliferation (GO:0046641)3.05025888
63cellular response to interferon-gamma (GO:0071346)3.03754780
64tolerance induction (GO:0002507)3.03604098
65regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.03280766
66regulation of B cell differentiation (GO:0045577)3.02862747
67thymic T cell selection (GO:0045061)3.02234223
68positive regulation of B cell differentiation (GO:0045579)3.01507506
69positive regulation of defense response to virus by host (GO:0002230)3.01319850
70B cell receptor signaling pathway (GO:0050853)2.99606388
71positive regulation of type 2 immune response (GO:0002830)2.95656389
72regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.95318919
73negative regulation of leukocyte mediated immunity (GO:0002704)2.89672966
74detection of external biotic stimulus (GO:0098581)2.88746342
75cellular extravasation (GO:0045123)2.88663316
76response to interferon-gamma (GO:0034341)2.88611620
77neutrophil activation (GO:0042119)2.88464490
78production of molecular mediator involved in inflammatory response (GO:0002532)2.88134392
79myeloid cell activation involved in immune response (GO:0002275)2.86868191
80regulation of interleukin-12 production (GO:0032655)2.86054436
81regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.85509180
82interferon-gamma secretion (GO:0072643)2.82609147
83mast cell activation (GO:0045576)2.82544464
84negative regulation of cytokine production involved in immune response (GO:0002719)2.82239650
85microglial cell activation (GO:0001774)2.81292640
86response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.80338522
87response to host immune response (GO:0052572)2.80338522
88NIK/NF-kappaB signaling (GO:0038061)2.79650040
89granulocyte activation (GO:0036230)2.79607196
90regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.79107556
91regulation of natural killer cell mediated immunity (GO:0002715)2.79107556
92germinal center formation (GO:0002467)2.78752748
93regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.78567279
94T-helper cell differentiation (GO:0042093)2.77879977
95CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.77879977
96antigen receptor-mediated signaling pathway (GO:0050851)2.77434260
97activated T cell proliferation (GO:0050798)2.77278720
98response to muramyl dipeptide (GO:0032495)2.76434195
99positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.75698526
100lymphocyte chemotaxis (GO:0048247)2.75392863

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.66160495
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.89417105
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.84654273
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.58995597
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.52233144
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.94123492
7* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.72526717
8* IRF8_27001747_Chip-Seq_BMDM_Mouse3.06187615
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.99170382
10RUNX_20019798_ChIP-Seq_JUKART_Human2.97974749
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.89029687
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70560083
13MYB_26560356_Chip-Seq_TH2_Human2.70016541
14* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.54962062
15* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.37402868
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34638924
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.19433750
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.16504877
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.16167036
20SPI1_23547873_ChIP-Seq_NB4_Human2.14925448
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.13540699
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12430807
23MYB_26560356_Chip-Seq_TH1_Human2.03795649
24SCL_19346495_ChIP-Seq_HPC-7_Human1.95649466
25GATA3_26560356_Chip-Seq_TH2_Human1.94842554
26* MAF_26560356_Chip-Seq_TH1_Human1.92372370
27* GATA3_27048872_Chip-Seq_THYMUS_Human1.90216724
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.88790774
29GATA1_22025678_ChIP-Seq_K562_Human1.86852186
30VDR_24787735_ChIP-Seq_THP-1_Human1.79836877
31VDR_24763502_ChIP-Seq_THP-1_Human1.77987517
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.76915177
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76267880
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74061518
35SPI1_23127762_ChIP-Seq_K562_Human1.71998611
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.55335125
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48603748
38UTX_26944678_Chip-Seq_JUKART_Human1.48451640
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47183998
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45969698
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44926926
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.44641051
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38097375
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34851181
45PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34664208
46VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.34496679
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34325139
48GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33756210
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33304786
50MAF_26560356_Chip-Seq_TH2_Human1.32019990
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.27455495
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23335799
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.21626737
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19484240
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19364694
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17785539
57VDR_21846776_ChIP-Seq_THP-1_Human1.15512008
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.15053129
59PU_27001747_Chip-Seq_BMDM_Mouse1.11238889
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11208875
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10507255
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06439083
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02720196
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01913490
65STAT1_20625510_ChIP-Seq_HELA_Human1.01725688
66RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00704967
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00167714
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97450093
69MYC_22102868_ChIP-Seq_BL_Human0.96823297
70* SMRT_27268052_Chip-Seq_Bcells_Human0.96784450
71* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94742547
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92590495
73GATA1_19941827_ChIP-Seq_MEL_Mouse0.90494419
74GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86280317
75* BCL6_27268052_Chip-Seq_Bcells_Human0.85261728
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83441002
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81371008
78BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81307075
79GATA3_26560356_Chip-Seq_TH1_Human0.80424501
80FLI1_27457419_Chip-Seq_LIVER_Mouse0.79265635
81GATA1_19941826_ChIP-Seq_K562_Human0.79088999
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.78824826
83IKZF1_21737484_ChIP-ChIP_HCT116_Human0.77373501
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76490149
85TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76423030
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.74580440
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.73316860
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.72258404
89* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71869105
90* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.71171451
91TCF7_22412390_ChIP-Seq_EML_Mouse0.70040685
92PCGF2_27294783_Chip-Seq_ESCs_Mouse0.69328961
93CIITA_25753668_ChIP-Seq_RAJI_Human0.68712319
94* P300_27268052_Chip-Seq_Bcells_Human0.68605024
95BCOR_27268052_Chip-Seq_Bcells_Human0.67199445
96GATA1_22383799_ChIP-Seq_G1ME_Mouse0.65350512
97PU.1_20513432_ChIP-Seq_Bcells_Mouse0.64689897
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64187630
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64118052
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.63897204

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.31175333
2MP0003724_increased_susceptibility_to4.29174957
3MP0005671_abnormal_response_to3.72904281
4MP0003436_decreased_susceptibility_to3.46877017
5MP0003303_peritoneal_inflammation3.37617643
6MP0009785_altered_susceptibility_to3.35741167
7MP0005387_immune_system_phenotype3.22911920
8MP0001790_abnormal_immune_system3.22911920
9MP0005000_abnormal_immune_tolerance3.15356870
10MP0001800_abnormal_humoral_immune3.13033244
11MP0002148_abnormal_hypersensitivity_rea3.02108085
12MP0000685_abnormal_immune_system2.91282043
13MP0006082_CNS_inflammation2.80993721
14MP0005025_abnormal_response_to2.80506855
15MP0002723_abnormal_immune_serum2.75516529
16MP0003763_abnormal_thymus_physiology2.68108079
17MP0002452_abnormal_antigen_presenting2.64968001
18MP0002419_abnormal_innate_immunity2.64241073
19MP0002420_abnormal_adaptive_immunity2.51058338
20MP0001819_abnormal_immune_cell2.49319100
21MP0003300_gastrointestinal_ulcer2.15489983
22MP0010155_abnormal_intestine_physiology2.14403434
23MP0002405_respiratory_system_inflammati2.00703866
24MP0001533_abnormal_skeleton_physiology1.97919823
25MP0001845_abnormal_inflammatory_respons1.93447591
26MP0000716_abnormal_immune_system1.90168640
27MP0002398_abnormal_bone_marrow1.87326222
28MP0009333_abnormal_splenocyte_physiolog1.85510121
29MP0009764_decreased_sensitivity_to1.81136135
30MP0004947_skin_inflammation1.71677816
31MP0008469_abnormal_protein_level1.64393058
32MP0000689_abnormal_spleen_morphology1.60678919
33MP0002166_altered_tumor_susceptibility1.58609720
34MP0003866_abnormal_defecation1.54008128
35MP0005464_abnormal_platelet_physiology1.53837709
36MP0001873_stomach_inflammation1.53810869
37MP0002138_abnormal_hepatobiliary_system1.51565653
38MP0002722_abnormal_immune_system1.49724794
39MP0005310_abnormal_salivary_gland1.46541500
40MP0002429_abnormal_blood_cell1.45878709
41MP0001853_heart_inflammation1.38096187
42MP0000465_gastrointestinal_hemorrhage1.35086288
43MP0003172_abnormal_lysosome_physiology1.34654341
44MP0003183_abnormal_peptide_metabolism1.30469727
45MP0000703_abnormal_thymus_morphology1.30215335
46MP0003075_altered_response_to1.25012352
47MP0002006_tumorigenesis1.19863426
48MP0009278_abnormal_bone_marrow1.15444394
49MP0001545_abnormal_hematopoietic_system1.15134967
50MP0005397_hematopoietic_system_phenotyp1.15134967
51MP0002933_joint_inflammation1.13449919
52MP0005166_decreased_susceptibility_to1.13261832
53MP0004510_myositis1.12952350
54MP0003191_abnormal_cellular_cholesterol1.12921840
55MP0000858_altered_metastatic_potential1.11583343
56MP0002277_abnormal_respiratory_mucosa1.11420832
57MP0003195_calcinosis1.05740290
58MP0002254_reproductive_system_inflammat1.04227371
59MP0005164_abnormal_response_to1.01822181
60MP0003448_altered_tumor_morphology0.99682450
61MP0002998_abnormal_bone_remodeling0.98545543
62MP0004381_abnormal_hair_follicle0.96197281
63MP0005058_abnormal_lysosome_morphology0.95339368
64MP0004883_abnormal_blood_vessel0.95321623
65MP0000343_altered_response_to0.94348939
66MP0006054_spinal_hemorrhage0.94302691
67MP0009763_increased_sensitivity_to0.94019156
68MP0002132_abnormal_respiratory_system0.92400526
69MP0003828_pulmonary_edema0.92111617
70MP0003045_fibrosis0.91997777
71MP0001663_abnormal_digestive_system0.91872521
72MP0001851_eye_inflammation0.86182092
73MP0003806_abnormal_nucleotide_metabolis0.83938372
74MP0005075_abnormal_melanosome_morpholog0.83864456
75MP0005451_abnormal_body_composition0.82574357
76MP0005390_skeleton_phenotype0.81904248
77MP0000604_amyloidosis0.79375453
78MP0002693_abnormal_pancreas_physiology0.75717160
79MP0008260_abnormal_autophagy0.75197079
80MP0009765_abnormal_xenobiotic_induced0.72766141
81MP0008004_abnormal_stomach_pH0.72391404
82MP0002332_abnormal_exercise_endurance0.72305941
83MP0003656_abnormal_erythrocyte_physiolo0.72177749
84MP0001501_abnormal_sleep_pattern0.71342094
85MP0000249_abnormal_blood_vessel0.70914598
86MP0009840_abnormal_foam_cell0.68049225
87MP0001542_abnormal_bone_strength0.67669472
88MP0002396_abnormal_hematopoietic_system0.66396149
89MP0003252_abnormal_bile_duct0.64896839
90MP0003690_abnormal_glial_cell0.63193383
91MP0000569_abnormal_digit_pigmentation0.62258771
92MP0003795_abnormal_bone_structure0.61343673
93MP0005319_abnormal_enzyme/_coenzyme0.61152949
94MP0005167_abnormal_blood-brain_barrier0.58545322
95MP0002136_abnormal_kidney_physiology0.58205108
96MP0004808_abnormal_hematopoietic_stem0.58079037
97MP0001986_abnormal_taste_sensitivity0.57900404
98MP0001764_abnormal_homeostasis0.56261420
99MP0000015_abnormal_ear_pigmentation0.54948392
100MP0005535_abnormal_body_temperature0.54340818

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.45096748
2Myositis (HP:0100614)5.12764437
3Retrobulbar optic neuritis (HP:0100654)5.08878976
4Optic neuritis (HP:0100653)5.08878976
5Orchitis (HP:0100796)4.97179389
6Elevated erythrocyte sedimentation rate (HP:0003565)4.78680929
7Eczematoid dermatitis (HP:0000976)4.70214254
8Recurrent bacterial skin infections (HP:0005406)4.44023027
9Recurrent abscess formation (HP:0002722)4.23696248
10T lymphocytopenia (HP:0005403)4.21502202
11Abnormality of T cell number (HP:0011839)4.17511275
12Recurrent fungal infections (HP:0002841)4.08910018
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.98699097
14Mediastinal lymphadenopathy (HP:0100721)3.83484850
15Abnormality of macrophages (HP:0004311)3.82917650
16Vasculitis (HP:0002633)3.81593531
17Meningitis (HP:0001287)3.78228027
18Pulmonary infiltrates (HP:0002113)3.75755122
19Chronic mucocutaneous candidiasis (HP:0002728)3.71404946
20Recurrent cutaneous fungal infections (HP:0011370)3.71404946
21Gastrointestinal infarctions (HP:0005244)3.68153362
22Increased IgM level (HP:0003496)3.66457084
23Hemoptysis (HP:0002105)3.56288731
24Encephalitis (HP:0002383)3.53371471
25Keratoconjunctivitis sicca (HP:0001097)3.52639627
26Abnormality of T cells (HP:0002843)3.43910990
27Keratoconjunctivitis (HP:0001096)3.42678971
28Recurrent skin infections (HP:0001581)3.36634345
29Recurrent viral infections (HP:0004429)3.32266328
30IgG deficiency (HP:0004315)3.28285631
31Obstructive lung disease (HP:0006536)3.23687090
32Chronic obstructive pulmonary disease (HP:0006510)3.23687090
33Panhypogammaglobulinemia (HP:0003139)3.23377628
34Autoimmune hemolytic anemia (HP:0001890)3.23075089
35Recurrent gram-negative bacterial infections (HP:0005420)3.14711471
36Abnormality of B cell number (HP:0010975)3.08026823
37Recurrent bronchitis (HP:0002837)3.07121644
38Gangrene (HP:0100758)2.90294605
39Leukocytosis (HP:0001974)2.88355218
40Autoimmune thrombocytopenia (HP:0001973)2.85469635
41Agammaglobulinemia (HP:0004432)2.85362870
42Abnormality of T cell physiology (HP:0011840)2.82085732
43Eosinophilia (HP:0001880)2.81954719
44Pustule (HP:0200039)2.78045581
45Abnormality of the prostate (HP:0008775)2.76168144
46Arterial thrombosis (HP:0004420)2.75414869
47Chest pain (HP:0100749)2.75153070
48Chronic diarrhea (HP:0002028)2.71384598
49Pulmonary embolism (HP:0002204)2.67305890
50Granulocytopenia (HP:0001913)2.66436079
51Abnormality of the pleura (HP:0002103)2.65016113
52B lymphocytopenia (HP:0010976)2.62179927
53Severe combined immunodeficiency (HP:0004430)2.57123975
54Abnormality of eosinophils (HP:0001879)2.56579403
55Abnormality of liposaccharide metabolism (HP:0010968)2.54295143
56Abnormality of glycosphingolipid metabolism (HP:0004343)2.54295143
57Abnormality of glycolipid metabolism (HP:0010969)2.54295143
58Hypergammaglobulinemia (HP:0010702)2.52829522
59Anorexia (HP:0002039)2.52358872
60Lymphopenia (HP:0001888)2.47423707
61Urticaria (HP:0001025)2.46937243
62Increased IgE level (HP:0003212)2.44455944
63Chronic otitis media (HP:0000389)2.43276489
64Stomach cancer (HP:0012126)2.38740656
65Recurrent sinusitis (HP:0011108)2.36476027
66Abnormality of cells of the lymphoid lineage (HP:0012140)2.34820719
67Gingivitis (HP:0000230)2.31906773
68Joint swelling (HP:0001386)2.29037795
69Spontaneous hematomas (HP:0007420)2.27946111
70Systemic lupus erythematosus (HP:0002725)2.24946930
71Thyroiditis (HP:0100646)2.22279717
72Hematochezia (HP:0002573)2.21966592
73Inflammation of the large intestine (HP:0002037)2.21862649
74Polyneuropathy (HP:0001271)2.21803179
75Increased cerebral lipofuscin (HP:0011813)2.21720774
76Prostate neoplasm (HP:0100787)2.21569751
77Prolonged bleeding time (HP:0003010)2.20513228
78Petechiae (HP:0000967)2.19920705
79Epistaxis (HP:0000421)2.17628821
80Episodic fever (HP:0001954)2.17125587
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.14007222
82Abnormality of the pericardium (HP:0001697)2.10906604
83Keratitis (HP:0000491)2.09459479
84Alveolar cell carcinoma (HP:0006519)2.09193619
85Gastrointestinal stroma tumor (HP:0100723)2.08806423
86Glomerulopathy (HP:0100820)2.07960200
87Cellulitis (HP:0100658)2.07953602
88Skin rash (HP:0000988)2.07541432
89Hypochromic anemia (HP:0001931)2.07422545
90Gingival bleeding (HP:0000225)2.06358041
91Vacuolated lymphocytes (HP:0001922)2.04083889
92Combined immunodeficiency (HP:0005387)2.03736167
93Gastrointestinal inflammation (HP:0004386)2.03380912
94Colitis (HP:0002583)2.01287741
95Abnormality of iron homeostasis (HP:0011031)2.00912718
96IgM deficiency (HP:0002850)1.95993767
97Neoplasm of the tracheobronchial system (HP:0100552)1.95981148
98Bronchitis (HP:0012387)1.95410633
99IgA deficiency (HP:0002720)1.95288491
100Increased serum ferritin (HP:0003281)1.94172915

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.74509943
2TXK4.23558343
3RIPK43.10913738
4TYK22.88174989
5MAP3K142.87163851
6BLK2.64850649
7IKBKE2.53753417
8TAOK32.43564222
9JAK32.32508921
10IKBKB2.22198937
11FES2.18879287
12IRAK42.14008111
13SYK2.10889989
14CSK2.08324760
15ZAP702.06065578
16TBK12.02198406
17BTK1.97665873
18JAK11.97119725
19KIT1.92387560
20ITK1.87870725
21TEC1.79913781
22BMPR21.76995212
23GRK61.73765807
24FRK1.72560986
25TNK21.71518891
26ERN11.69059237
27LYN1.52800224
28GRK71.46400761
29CSF1R1.42163702
30LCK1.41681176
31MAP3K131.35640033
32HCK1.35118063
33ADRBK21.35008486
34MAP2K31.26004755
35MATK1.15330076
36NLK1.14224191
37JAK21.11953754
38IRAK11.05978920
39PRPF4B1.05877405
40MAP3K31.04322218
41SIK31.03269790
42IRAK31.03034187
43FGFR31.02084480
44PRKCQ0.95620855
45TGFBR20.94943508
46MAP3K110.92430030
47CHUK0.90145727
48FGR0.89094584
49CAMKK20.84360581
50HIPK20.82592724
51FGFR40.80931601
52MARK30.79860844
53MAP2K60.78086933
54STK100.77052414
55PIK3CG0.77035710
56PDK10.73990991
57EPHB10.69736241
58PIM10.69582363
59TLK10.69093110
60MAP3K120.65247713
61EPHA30.63353263
62ACVR1B0.63325350
63CDC42BPA0.62339047
64TRPM70.60744210
65TAOK20.60526881
66NME20.59501039
67MAP2K20.57903256
68MST40.57350588
69MAP3K10.57279155
70KDR0.55132425
71MAPK70.54278126
72MAPK110.49940106
73ABL10.49586277
74TAOK10.48102508
75MAP3K50.46272404
76PINK10.43133568
77MAP3K70.41797146
78DAPK20.40583505
79FYN0.40510275
80GRK10.40122488
81NUAK10.38960796
82PTK2B0.37611941
83ADRBK10.37143660
84GRK50.35054274
85MAPKAPK20.34747806
86EGFR0.30685942
87PDPK10.30474301
88PRKCD0.30158510
89IGF1R0.29521421
90LRRK20.28841012
91RPS6KA50.28609558
92INSR0.28076792
93CAMKK10.27187180
94IRAK20.26834847
95TESK20.26679305
96MELK0.26434161
97RIPK10.26176419
98MOS0.26166815
99MAP4K20.25761387
100CDK40.23784972

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.94294368
2Graft-versus-host disease_Homo sapiens_hsa053323.79818699
3Autoimmune thyroid disease_Homo sapiens_hsa053203.56068143
4Asthma_Homo sapiens_hsa053103.36568513
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.23679093
6Primary immunodeficiency_Homo sapiens_hsa053403.15849625
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.07702340
8Type I diabetes mellitus_Homo sapiens_hsa049402.99403639
9Leishmaniasis_Homo sapiens_hsa051402.84265866
10Staphylococcus aureus infection_Homo sapiens_hsa051502.81997561
11Antigen processing and presentation_Homo sapiens_hsa046122.51636209
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.23358444
13Osteoclast differentiation_Homo sapiens_hsa043802.22866219
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.06631230
15Hematopoietic cell lineage_Homo sapiens_hsa046402.02769265
16Toll-like receptor signaling pathway_Homo sapiens_hsa046202.01055787
17Rheumatoid arthritis_Homo sapiens_hsa053232.00006963
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.96077995
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.88713391
20Viral myocarditis_Homo sapiens_hsa054161.87853906
21Measles_Homo sapiens_hsa051621.85788322
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.83358666
23Tuberculosis_Homo sapiens_hsa051521.80211680
24T cell receptor signaling pathway_Homo sapiens_hsa046601.74391312
25B cell receptor signaling pathway_Homo sapiens_hsa046621.68862175
26Herpes simplex infection_Homo sapiens_hsa051681.62827077
27Malaria_Homo sapiens_hsa051441.61908873
28Influenza A_Homo sapiens_hsa051641.60113562
29Toxoplasmosis_Homo sapiens_hsa051451.52241269
30TNF signaling pathway_Homo sapiens_hsa046681.46449523
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.45021552
32African trypanosomiasis_Homo sapiens_hsa051431.41039554
33Legionellosis_Homo sapiens_hsa051341.37207513
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35329182
35Pertussis_Homo sapiens_hsa051331.23362822
36Chemokine signaling pathway_Homo sapiens_hsa040621.17265714
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08916714
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07439291
39Other glycan degradation_Homo sapiens_hsa005111.04878038
40Hepatitis C_Homo sapiens_hsa051600.95888121
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95583919
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92010099
43Phagosome_Homo sapiens_hsa041450.91336958
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86821486
45Hepatitis B_Homo sapiens_hsa051610.83148175
46Lysosome_Homo sapiens_hsa041420.81470968
47Acute myeloid leukemia_Homo sapiens_hsa052210.78120734
48Platelet activation_Homo sapiens_hsa046110.68916328
49Shigellosis_Homo sapiens_hsa051310.67172556
50Salmonella infection_Homo sapiens_hsa051320.66578414
51Apoptosis_Homo sapiens_hsa042100.65044169
52Epstein-Barr virus infection_Homo sapiens_hsa051690.62968745
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62200468
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.60745704
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60700792
56Systemic lupus erythematosus_Homo sapiens_hsa053220.56338806
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55416026
58HTLV-I infection_Homo sapiens_hsa051660.46800166
59Regulation of autophagy_Homo sapiens_hsa041400.45223546
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44197848
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.42866125
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.42252863
63Linoleic acid metabolism_Homo sapiens_hsa005910.41829446
64Prolactin signaling pathway_Homo sapiens_hsa049170.41444964
65Arachidonic acid metabolism_Homo sapiens_hsa005900.39935656
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39153064
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.35544624
68Ether lipid metabolism_Homo sapiens_hsa005650.33890318
69Caffeine metabolism_Homo sapiens_hsa002320.32594642
70Sulfur metabolism_Homo sapiens_hsa009200.31506253
71Dorso-ventral axis formation_Homo sapiens_hsa043200.29060581
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28340525
73Viral carcinogenesis_Homo sapiens_hsa052030.27455399
74Complement and coagulation cascades_Homo sapiens_hsa046100.26184928
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24860541
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24126683
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23380559
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21888427
79VEGF signaling pathway_Homo sapiens_hsa043700.21604131
80Insulin resistance_Homo sapiens_hsa049310.21238348
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20622773
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.18682935
83ABC transporters_Homo sapiens_hsa020100.17087230
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.17074420
85FoxO signaling pathway_Homo sapiens_hsa040680.16745297
86Collecting duct acid secretion_Homo sapiens_hsa049660.16067797
87MAPK signaling pathway_Homo sapiens_hsa040100.15978570
88Endocytosis_Homo sapiens_hsa041440.15763815
89Amoebiasis_Homo sapiens_hsa051460.15215134
90Pancreatic cancer_Homo sapiens_hsa052120.13048943
91Mineral absorption_Homo sapiens_hsa049780.10093608
92Sphingolipid metabolism_Homo sapiens_hsa006000.09258222
93Tryptophan metabolism_Homo sapiens_hsa003800.09233684
94Type II diabetes mellitus_Homo sapiens_hsa049300.08927317
95Renin-angiotensin system_Homo sapiens_hsa046140.08068304
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.07601058
97Phototransduction_Homo sapiens_hsa047440.05651333
98Non-small cell lung cancer_Homo sapiens_hsa052230.05289101
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.03927403
100Glycerolipid metabolism_Homo sapiens_hsa005610.03657411

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