

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | piRNA metabolic process (GO:0034587) | 8.67523673 |
| 2 | regulation of meiosis I (GO:0060631) | 7.16365406 |
| 3 | DNA methylation involved in gamete generation (GO:0043046) | 6.37090789 |
| 4 | synaptonemal complex assembly (GO:0007130) | 6.17931181 |
| 5 | synaptonemal complex organization (GO:0070193) | 5.70370323 |
| 6 | male meiosis (GO:0007140) | 5.61077737 |
| 7 | gonadal mesoderm development (GO:0007506) | 5.36250300 |
| 8 | gene silencing by RNA (GO:0031047) | 4.77989813 |
| 9 | positive regulation of male gonad development (GO:2000020) | 4.68985772 |
| 10 | DNA unwinding involved in DNA replication (GO:0006268) | 4.65763456 |
| 11 | negative regulation of meiosis (GO:0045835) | 4.57050308 |
| 12 | nuclear pore organization (GO:0006999) | 4.53636726 |
| 13 | nuclear pore complex assembly (GO:0051292) | 4.51136831 |
| 14 | meiotic nuclear division (GO:0007126) | 4.38998554 |
| 15 | heterochromatin organization (GO:0070828) | 4.24584621 |
| 16 | cellular protein complex localization (GO:0034629) | 4.06234661 |
| 17 | chromosome organization involved in meiosis (GO:0070192) | 4.02874164 |
| 18 | regulation of male gonad development (GO:2000018) | 3.97238455 |
| 19 | male meiosis I (GO:0007141) | 3.96992509 |
| 20 | DNA alkylation (GO:0006305) | 3.96733338 |
| 21 | DNA methylation (GO:0006306) | 3.96733338 |
| 22 | sex determination (GO:0007530) | 3.90910015 |
| 23 | oocyte development (GO:0048599) | 3.90230413 |
| 24 | protein complex localization (GO:0031503) | 3.85558876 |
| 25 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 3.82668198 |
| 26 | sex differentiation (GO:0007548) | 3.76677870 |
| 27 | female gamete generation (GO:0007292) | 3.75469305 |
| 28 | meiotic cell cycle (GO:0051321) | 3.71648433 |
| 29 | regulation of chromatin binding (GO:0035561) | 3.71605664 |
| 30 | gene silencing (GO:0016458) | 3.69931302 |
| 31 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.69719194 |
| 32 | histone H4-K12 acetylation (GO:0043983) | 3.69294280 |
| 33 | mitotic nuclear envelope disassembly (GO:0007077) | 3.68382818 |
| 34 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.57328599 |
| 35 | meiosis I (GO:0007127) | 3.57261971 |
| 36 | regulation of meiosis (GO:0040020) | 3.56267138 |
| 37 | regulation of gene silencing by RNA (GO:0060966) | 3.53651457 |
| 38 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.53651457 |
| 39 | regulation of gene silencing by miRNA (GO:0060964) | 3.53651457 |
| 40 | paraxial mesoderm development (GO:0048339) | 3.52223194 |
| 41 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.52115287 |
| 42 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.52115287 |
| 43 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 3.51620325 |
| 44 | membrane disassembly (GO:0030397) | 3.50825647 |
| 45 | nuclear envelope disassembly (GO:0051081) | 3.50825647 |
| 46 | mitotic metaphase plate congression (GO:0007080) | 3.50730770 |
| 47 | pre-miRNA processing (GO:0031054) | 3.50336863 |
| 48 | regulation of RNA export from nucleus (GO:0046831) | 3.49256087 |
| 49 | DNA strand elongation (GO:0022616) | 3.48881294 |
| 50 | oogenesis (GO:0048477) | 3.48651072 |
| 51 | negative regulation of retinoic acid receptor signaling pathway (GO:0048387) | 3.47938405 |
| 52 | histone H2A monoubiquitination (GO:0035518) | 3.47023586 |
| 53 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.46915469 |
| 54 | meiotic cell cycle process (GO:1903046) | 3.45940503 |
| 55 | positive regulation of meiosis (GO:0045836) | 3.45552754 |
| 56 | regulation of histone H3-K9 methylation (GO:0051570) | 3.45159919 |
| 57 | pore complex assembly (GO:0046931) | 3.44093761 |
| 58 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.41790212 |
| 59 | mitotic sister chromatid cohesion (GO:0007064) | 3.40974290 |
| 60 | positive regulation of meiotic cell cycle (GO:0051446) | 3.34668532 |
| 61 | regulation of sister chromatid cohesion (GO:0007063) | 3.34312269 |
| 62 | DNA replication initiation (GO:0006270) | 3.32290805 |
| 63 | positive regulation of chromosome segregation (GO:0051984) | 3.31917371 |
| 64 | chromatin assembly (GO:0031497) | 3.31487261 |
| 65 | inner cell mass cell proliferation (GO:0001833) | 3.27257129 |
| 66 | sister chromatid segregation (GO:0000819) | 3.27070004 |
| 67 | oocyte maturation (GO:0001556) | 3.24933601 |
| 68 | regulation of chromosome segregation (GO:0051983) | 3.23828714 |
| 69 | negative regulation of meiotic cell cycle (GO:0051447) | 3.23655635 |
| 70 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.22881154 |
| 71 | regulation of mammary gland epithelial cell proliferation (GO:0033599) | 3.20876324 |
| 72 | protein localization to kinetochore (GO:0034501) | 3.19130476 |
| 73 | fusion of sperm to egg plasma membrane (GO:0007342) | 3.17316862 |
| 74 | metaphase plate congression (GO:0051310) | 3.16772580 |
| 75 | negative regulation of chromosome segregation (GO:0051985) | 3.15772400 |
| 76 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.12865403 |
| 77 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.12459504 |
| 78 | protein localization to chromosome, centromeric region (GO:0071459) | 3.12124822 |
| 79 | protein localization to chromosome (GO:0034502) | 3.11969120 |
| 80 | regulation of spindle organization (GO:0090224) | 3.10054849 |
| 81 | meiotic chromosome segregation (GO:0045132) | 3.09353328 |
| 82 | mitotic spindle checkpoint (GO:0071174) | 3.08749143 |
| 83 | mitotic spindle assembly checkpoint (GO:0007094) | 3.08487625 |
| 84 | convergent extension (GO:0060026) | 3.03953193 |
| 85 | * chromosome condensation (GO:0030261) | 3.03665455 |
| 86 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.03333542 |
| 87 | negative regulation of sister chromatid segregation (GO:0033046) | 3.03333542 |
| 88 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.03333542 |
| 89 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.03333542 |
| 90 | sister chromatid cohesion (GO:0007062) | 3.01821991 |
| 91 | ribosomal small subunit biogenesis (GO:0042274) | 3.01249518 |
| 92 | DNA methylation or demethylation (GO:0044728) | 3.00687836 |
| 93 | male sex determination (GO:0030238) | 2.99036628 |
| 94 | spindle assembly checkpoint (GO:0071173) | 2.99015864 |
| 95 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.97630822 |
| 96 | spindle checkpoint (GO:0031577) | 2.97046072 |
| 97 | nuclear envelope organization (GO:0006998) | 2.96848892 |
| 98 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 2.96578133 |
| 99 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 2.96578133 |
| 100 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 2.96578133 |
| 101 | regulation of nucleobase-containing compound transport (GO:0032239) | 2.96495209 |
| 102 | DNA replication checkpoint (GO:0000076) | 2.96167153 |
| 103 | negative regulation of histone methylation (GO:0031061) | 2.95537023 |
| 104 | * mitotic chromosome condensation (GO:0007076) | 2.93439936 |
| 105 | mitotic sister chromatid segregation (GO:0000070) | 2.90342520 |
| 106 | protein K6-linked ubiquitination (GO:0085020) | 2.89323148 |
| 107 | regulation of mitotic sister chromatid separation (GO:0010965) | 2.86972050 |
| 108 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.86972050 |
| 109 | regulation of sister chromatid segregation (GO:0033045) | 2.86972050 |
| 110 | regulation of mitotic spindle organization (GO:0060236) | 2.85847670 |
| 111 | regulation of NFAT protein import into nucleus (GO:0051532) | 2.84764639 |
| 112 | establishment of chromosome localization (GO:0051303) | 2.84526256 |
| 113 | regulation of female gonad development (GO:2000194) | 2.83488402 |
| 114 | histone H4-K5 acetylation (GO:0043981) | 2.83226031 |
| 115 | histone H4-K8 acetylation (GO:0043982) | 2.83226031 |
| 116 | regulation of meiotic cell cycle (GO:0051445) | 2.82806459 |
| 117 | DNA synthesis involved in DNA repair (GO:0000731) | 2.81703411 |
| 118 | negative regulation of DNA repair (GO:0045738) | 2.78613266 |
| 119 | establishment of integrated proviral latency (GO:0075713) | 2.77273244 |
| 120 | chromatin assembly or disassembly (GO:0006333) | 2.76561281 |
| 121 | mitotic G1 DNA damage checkpoint (GO:0031571) | 2.75624403 |
| 122 | DNA topological change (GO:0006265) | 2.73845900 |
| 123 | chromatin remodeling at centromere (GO:0031055) | 2.70799815 |
| 124 | CENP-A containing nucleosome assembly (GO:0034080) | 2.69961853 |
| 125 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 2.69536086 |
| 126 | mRNA stabilization (GO:0048255) | 2.65657249 |
| 127 | RNA stabilization (GO:0043489) | 2.65657249 |
| 128 | adherens junction assembly (GO:0034333) | 2.65334379 |
| 129 | synapsis (GO:0007129) | 2.54849966 |
| 130 | trophoblast giant cell differentiation (GO:0060707) | 2.54355529 |
| 131 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 2.53470664 |
| 132 | establishment of mitotic spindle localization (GO:0040001) | 2.53310743 |
| 133 | formation of translation preinitiation complex (GO:0001731) | 2.53236907 |
| 134 | regulation of early endosome to late endosome transport (GO:2000641) | 2.52731731 |
| 135 | notochord development (GO:0030903) | 2.51880119 |
| 136 | ATP-dependent chromatin remodeling (GO:0043044) | 2.51613104 |
| 137 | DNA replication-independent nucleosome organization (GO:0034724) | 2.51348609 |
| 138 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.51348609 |
| 139 | histone H3-K36 demethylation (GO:0070544) | 2.50494488 |
| 140 | regulation of branching involved in prostate gland morphogenesis (GO:0060687) | 2.48530121 |
| 141 | regulation of DNA methylation (GO:0044030) | 2.46329944 |
| 142 | telomere maintenance via recombination (GO:0000722) | 2.44936695 |
| 143 | mitotic recombination (GO:0006312) | 2.44548601 |
| 144 | * DNA packaging (GO:0006323) | 2.44071830 |
| 145 | DNA duplex unwinding (GO:0032508) | 2.43903027 |
| 146 | regulation of translational fidelity (GO:0006450) | 2.43604364 |
| 147 | focal adhesion assembly (GO:0048041) | 2.43135678 |
| 148 | cell-substrate adherens junction assembly (GO:0007045) | 2.43135678 |
| 149 | negative regulation of gene silencing (GO:0060969) | 2.42513229 |
| 150 | Wnt signaling pathway, planar cell polarity pathway (GO:0060071) | 2.42286185 |
| 151 | embryonic body morphogenesis (GO:0010172) | 2.39699511 |
| 152 | negative regulation of fibroblast apoptotic process (GO:2000270) | 2.37489143 |
| 153 | positive regulation of SMAD protein import into nucleus (GO:0060391) | 2.37307030 |
| 154 | outer ear morphogenesis (GO:0042473) | 2.36684484 |
| 155 | regulation of transcription from RNA polymerase I promoter (GO:0006356) | 2.35515387 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.93667957 |
| 2 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 5.25637873 |
| 3 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 4.48577598 |
| 4 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 3.69805122 |
| 5 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.33607149 |
| 6 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 2.89568226 |
| 7 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 2.89568226 |
| 8 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 2.89568226 |
| 9 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.84655757 |
| 10 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.79320064 |
| 11 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.70701990 |
| 12 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.55696640 |
| 13 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.41036988 |
| 14 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.33951227 |
| 15 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.21017996 |
| 16 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.20869074 |
| 17 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.17736776 |
| 18 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.09218730 |
| 19 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 2.04215345 |
| 20 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 2.02835777 |
| 21 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.02498887 |
| 22 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.99477641 |
| 23 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.98092876 |
| 24 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.92040737 |
| 25 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.84986905 |
| 26 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.74928372 |
| 27 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.71383033 |
| 28 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.71301670 |
| 29 | MYC_22102868_ChIP-Seq_BL_Human | 1.69090381 |
| 30 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.62134250 |
| 31 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.62031674 |
| 32 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.59975796 |
| 33 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.58552639 |
| 34 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.58279575 |
| 35 | * THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.56900898 |
| 36 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.55513896 |
| 37 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.55103354 |
| 38 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.54427796 |
| 39 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.51807127 |
| 40 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.51192038 |
| 41 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.48863458 |
| 42 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.47467519 |
| 43 | * WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.47266172 |
| 44 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.47258559 |
| 45 | * TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.44109508 |
| 46 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.42743678 |
| 47 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.38661803 |
| 48 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.38407065 |
| 49 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.38138865 |
| 50 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.37188218 |
| 51 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.36297634 |
| 52 | * TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.35654774 |
| 53 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.33872341 |
| 54 | ATF3_27146783_Chip-Seq_COLON_Human | 1.32883837 |
| 55 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.28926639 |
| 56 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.28682795 |
| 57 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.28589550 |
| 58 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.28012824 |
| 59 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.27882152 |
| 60 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.24472151 |
| 61 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.23127928 |
| 62 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.22425431 |
| 63 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.21849246 |
| 64 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.20309977 |
| 65 | * CHD1_26751641_Chip-Seq_LNCaP_Human | 1.20120053 |
| 66 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.19975750 |
| 67 | * P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.19088607 |
| 68 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.17349975 |
| 69 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.17168269 |
| 70 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.16562062 |
| 71 | * NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 1.16385823 |
| 72 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.15104930 |
| 73 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.14326955 |
| 74 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.12842079 |
| 75 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 1.12021286 |
| 76 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.11542801 |
| 77 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.10585665 |
| 78 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 1.10158498 |
| 79 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.06586259 |
| 80 | * UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.06225001 |
| 81 | * TCF7_22412390_ChIP-Seq_EML_Mouse | 1.05744218 |
| 82 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.05587101 |
| 83 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.05532506 |
| 84 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.04164560 |
| 85 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.03517761 |
| 86 | * ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.03491793 |
| 87 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.03218196 |
| 88 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.03123532 |
| 89 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.02945889 |
| 90 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.02861010 |
| 91 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 1.02571708 |
| 92 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.01061986 |
| 93 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.00631801 |
| 94 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.98993378 |
| 95 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.97617352 |
| 96 | * KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.97598725 |
| 97 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.97551752 |
| 98 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.97034353 |
| 99 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.96734406 |
| 100 | * NCOR1_26117541_ChIP-Seq_K562_Human | 0.96563179 |
| 101 | * KDM2B_26808549_Chip-Seq_DND41_Human | 0.96088986 |
| 102 | * TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.95093428 |
| 103 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.95031577 |
| 104 | TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 0.94995870 |
| 105 | TP53_22127205_ChIP-Seq_IMR90_Human | 0.94861382 |
| 106 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.94652538 |
| 107 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.93586328 |
| 108 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.93301472 |
| 109 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 0.93179700 |
| 110 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.92658704 |
| 111 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.92002898 |
| 112 | * KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.91832871 |
| 113 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.91473879 |
| 114 | * KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.91450639 |
| 115 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.89827588 |
| 116 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 0.88071093 |
| 117 | * ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.87625260 |
| 118 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.87046777 |
| 119 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.86854413 |
| 120 | PRDM14_21183938_ChIP-Seq_MESCs_Mouse | 0.86503763 |
| 121 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.85769365 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008877_abnormal_DNA_methylation | 5.65182684 |
| 2 | MP0008995_early_reproductive_senescence | 3.80719115 |
| 3 | MP0003123_paternal_imprinting | 2.95807910 |
| 4 | MP0003111_abnormal_nucleus_morphology | 2.93697916 |
| 5 | MP0004957_abnormal_blastocyst_morpholog | 2.82363864 |
| 6 | MP0003693_abnormal_embryo_hatching | 2.80073755 |
| 7 | MP0002210_abnormal_sex_determination | 2.67561778 |
| 8 | MP0003315_abnormal_perineum_morphology | 2.66449358 |
| 9 | MP0010094_abnormal_chromosome_stability | 2.62127819 |
| 10 | MP0003878_abnormal_ear_physiology | 2.60361956 |
| 11 | MP0005377_hearing/vestibular/ear_phenot | 2.60361956 |
| 12 | MP0003786_premature_aging | 2.59543142 |
| 13 | MP0001929_abnormal_gametogenesis | 2.40710753 |
| 14 | MP0003077_abnormal_cell_cycle | 2.37317942 |
| 15 | MP0008057_abnormal_DNA_replication | 2.32955463 |
| 16 | MP0002653_abnormal_ependyma_morphology | 2.32413798 |
| 17 | MP0001145_abnormal_male_reproductive | 2.24317788 |
| 18 | MP0000653_abnormal_sex_gland | 2.07429163 |
| 19 | MP0001730_embryonic_growth_arrest | 2.04030206 |
| 20 | MP0005076_abnormal_cell_differentiation | 2.02703937 |
| 21 | MP0010352_gastrointestinal_tract_polyps | 2.00369582 |
| 22 | MP0008438_abnormal_cutaneous_collagen | 1.94136705 |
| 23 | MP0006292_abnormal_olfactory_placode | 1.87585333 |
| 24 | MP0003121_genomic_imprinting | 1.85462467 |
| 25 | MP0000566_synostosis | 1.83939458 |
| 26 | MP0008007_abnormal_cellular_replicative | 1.79716641 |
| 27 | MP0005257_abnormal_intraocular_pressure | 1.79477834 |
| 28 | MP0003718_maternal_effect | 1.74239231 |
| 29 | MP0008058_abnormal_DNA_repair | 1.72992340 |
| 30 | MP0003705_abnormal_hypodermis_morpholog | 1.70178249 |
| 31 | MP0008932_abnormal_embryonic_tissue | 1.65954336 |
| 32 | MP0003698_abnormal_male_reproductive | 1.65268903 |
| 33 | MP0002084_abnormal_developmental_patter | 1.65116171 |
| 34 | MP0005623_abnormal_meninges_morphology | 1.65102194 |
| 35 | MP0002796_impaired_skin_barrier | 1.64818989 |
| 36 | MP0000350_abnormal_cell_proliferation | 1.62512247 |
| 37 | MP0005380_embryogenesis_phenotype | 1.61803389 |
| 38 | MP0001672_abnormal_embryogenesis/_devel | 1.61803389 |
| 39 | MP0010307_abnormal_tumor_latency | 1.61112947 |
| 40 | MP0010368_abnormal_lymphatic_system | 1.58529283 |
| 41 | MP0002085_abnormal_embryonic_tissue | 1.58348989 |
| 42 | MP0002697_abnormal_eye_size | 1.55459006 |
| 43 | MP0000678_abnormal_parathyroid_gland | 1.53816060 |
| 44 | MP0002160_abnormal_reproductive_system | 1.53167584 |
| 45 | MP0004197_abnormal_fetal_growth/weight/ | 1.50786794 |
| 46 | MP0001697_abnormal_embryo_size | 1.46535151 |
| 47 | MP0000537_abnormal_urethra_morphology | 1.45286265 |
| 48 | MP0003119_abnormal_digestive_system | 1.45173252 |
| 49 | MP0003984_embryonic_growth_retardation | 1.44909814 |
| 50 | MP0001346_abnormal_lacrimal_gland | 1.44287012 |
| 51 | MP0002088_abnormal_embryonic_growth/wei | 1.43232338 |
| 52 | MP0005501_abnormal_skin_physiology | 1.41786883 |
| 53 | MP0003941_abnormal_skin_development | 1.37845646 |
| 54 | MP0005410_abnormal_fertilization | 1.36184765 |
| 55 | MP0002249_abnormal_larynx_morphology | 1.35689606 |
| 56 | MP0009278_abnormal_bone_marrow | 1.34643839 |
| 57 | MP0000762_abnormal_tongue_morphology | 1.33650551 |
| 58 | MP0003453_abnormal_keratinocyte_physiol | 1.33534885 |
| 59 | MP0002086_abnormal_extraembryonic_tissu | 1.33397119 |
| 60 | MP0001727_abnormal_embryo_implantation | 1.31651573 |
| 61 | MP0000049_abnormal_middle_ear | 1.31518733 |
| 62 | MP0001119_abnormal_female_reproductive | 1.30440071 |
| 63 | MP0002089_abnormal_postnatal_growth/wei | 1.30235969 |
| 64 | MP0002161_abnormal_fertility/fecundity | 1.24481622 |
| 65 | MP0004233_abnormal_muscle_weight | 1.23947118 |
| 66 | MP0005409_darkened_coat_color | 1.21704319 |
| 67 | MP0003937_abnormal_limbs/digits/tail_de | 1.21183207 |
| 68 | MP0004185_abnormal_adipocyte_glucose | 1.20676667 |
| 69 | MP0003115_abnormal_respiratory_system | 1.19629843 |
| 70 | MP0002080_prenatal_lethality | 1.17088211 |
| 71 | MP0009672_abnormal_birth_weight | 1.16627538 |
| 72 | MP0002102_abnormal_ear_morphology | 1.15522307 |
| 73 | MP0010030_abnormal_orbit_morphology | 1.15431952 |
| 74 | MP0002233_abnormal_nose_morphology | 1.14475698 |
| 75 | MP0003283_abnormal_digestive_organ | 1.13397555 |
| 76 | MP0003890_abnormal_embryonic-extraembry | 1.11597115 |
| 77 | MP0003699_abnormal_female_reproductive | 1.10382178 |
| 78 | MP0003936_abnormal_reproductive_system | 1.09055933 |
| 79 | MP0009053_abnormal_anal_canal | 1.08412610 |
| 80 | MP0001661_extended_life_span | 1.08126928 |
| 81 | MP0005395_other_phenotype | 1.05425889 |
| 82 | MP0003567_abnormal_fetal_cardiomyocyte | 1.05320398 |
| 83 | MP0005389_reproductive_system_phenotype | 1.05224860 |
| 84 | MP0002254_reproductive_system_inflammat | 1.03224030 |
| 85 | MP0000428_abnormal_craniofacial_morphol | 1.02625472 |
| 86 | MP0009384_cardiac_valve_regurgitation | 1.01305844 |
| 87 | MP0008260_abnormal_autophagy | 1.01021275 |
| 88 | MP0000579_abnormal_nail_morphology | 1.00669279 |
| 89 | MP0003385_abnormal_body_wall | 1.00092886 |
| 90 | MP0009250_abnormal_appendicular_skeleto | 0.99082611 |
| 91 | MP0010234_abnormal_vibrissa_follicle | 0.98693235 |
| 92 | MP0004272_abnormal_basement_membrane | 0.96967839 |
| 93 | MP0000733_abnormal_muscle_development | 0.96100667 |
| 94 | MP0009703_decreased_birth_body | 0.95737651 |
| 95 | MP0003942_abnormal_urinary_system | 0.94485342 |
| 96 | MP0001299_abnormal_eye_distance/ | 0.93623264 |
| 97 | MP0002060_abnormal_skin_morphology | 0.92780262 |
| 98 | MP0001915_intracranial_hemorrhage | 0.91050048 |
| 99 | MP0000490_abnormal_crypts_of | 0.90663988 |
| 100 | MP0005394_taste/olfaction_phenotype | 0.90634376 |
| 101 | MP0005499_abnormal_olfactory_system | 0.90634376 |
| 102 | MP0001849_ear_inflammation | 0.90522504 |
| 103 | MP0005451_abnormal_body_composition | 0.90307013 |
| 104 | MP0001286_abnormal_eye_development | 0.87986004 |
| 105 | MP0002114_abnormal_axial_skeleton | 0.86872201 |
| 106 | MP0008789_abnormal_olfactory_epithelium | 0.86478881 |
| 107 | MP0009379_abnormal_foot_pigmentation | 0.86203206 |
| 108 | MP0003755_abnormal_palate_morphology | 0.84374324 |
| 109 | MP0005503_abnormal_tendon_morphology | 0.84124471 |
| 110 | MP0003935_abnormal_craniofacial_develop | 0.83655495 |
| 111 | MP0000313_abnormal_cell_death | 0.78699842 |
| 112 | MP0002092_abnormal_eye_morphology | 0.78697450 |
| 113 | MP0005647_abnormal_sex_gland | 0.77594051 |
| 114 | MP0000432_abnormal_head_morphology | 0.76516246 |
| 115 | MP0005023_abnormal_wound_healing | 0.74571177 |
| 116 | MP0003787_abnormal_imprinting | 0.74489902 |
| 117 | MP0003122_maternal_imprinting | 0.74389437 |
| 118 | MP0001293_anophthalmia | 0.73900278 |
| 119 | MP0003566_abnormal_cell_adhesion | 0.72515015 |
| 120 | MP0002111_abnormal_tail_morphology | 0.71224327 |
| 121 | MP0006138_congestive_heart_failure | 0.71094061 |
| 122 | MP0004264_abnormal_extraembryonic_tissu | 0.69200576 |
| 123 | MP0003861_abnormal_nervous_system | 0.68236799 |
| 124 | MP0000534_abnormal_ureter_morphology | 0.67267183 |
| 125 | MP0003091_abnormal_cell_migration | 0.66957269 |
| 126 | MP0002019_abnormal_tumor_incidence | 0.66583796 |
| 127 | MP0005621_abnormal_cell_physiology | 0.66432308 |
| 128 | MP0000462_abnormal_digestive_system | 0.66306936 |
| 129 | MP0002116_abnormal_craniofacial_bone | 0.65374617 |
| 130 | MP0005508_abnormal_skeleton_morphology | 0.64055787 |
| 131 | MP0002877_abnormal_melanocyte_morpholog | 0.63560801 |
| 132 | MP0005248_abnormal_Harderian_gland | 0.63345086 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Male infertility (HP:0003251) | 6.18995584 |
| 2 | Gonadotropin excess (HP:0000837) | 3.81970648 |
| 3 | Gonadal dysgenesis (HP:0000133) | 3.67131121 |
| 4 | Facial hemangioma (HP:0000329) | 3.60574397 |
| 5 | Ankle contracture (HP:0006466) | 3.44004869 |
| 6 | Metaphyseal cupping (HP:0003021) | 3.38414684 |
| 7 | Azoospermia (HP:0000027) | 3.31276149 |
| 8 | Abnormal spermatogenesis (HP:0008669) | 3.08618786 |
| 9 | Abnormal sex determination (HP:0012244) | 2.96181994 |
| 10 | Sex reversal (HP:0012245) | 2.96181994 |
| 11 | Hand muscle atrophy (HP:0009130) | 2.95644483 |
| 12 | Secondary amenorrhea (HP:0000869) | 2.90736111 |
| 13 | Tongue fasciculations (HP:0001308) | 2.87209072 |
| 14 | Infertility (HP:0000789) | 2.87045231 |
| 15 | Abnormality of the phalanges of the hallux (HP:0010057) | 2.85105607 |
| 16 | Breast hypoplasia (HP:0003187) | 2.83017067 |
| 17 | Muscle fibrillation (HP:0010546) | 2.75867330 |
| 18 | Male pseudohermaphroditism (HP:0000037) | 2.73701046 |
| 19 | 11 pairs of ribs (HP:0000878) | 2.70742384 |
| 20 | Selective tooth agenesis (HP:0001592) | 2.70263306 |
| 21 | Shawl scrotum (HP:0000049) | 2.64048262 |
| 22 | Impulsivity (HP:0100710) | 2.62506272 |
| 23 | Premature ovarian failure (HP:0008209) | 2.61706280 |
| 24 | Ependymoma (HP:0002888) | 2.61352145 |
| 25 | Abnormality of the labia minora (HP:0012880) | 2.60833801 |
| 26 | Missing ribs (HP:0000921) | 2.54490947 |
| 27 | Proximal placement of thumb (HP:0009623) | 2.53622163 |
| 28 | Abnormality of the lower motor neuron (HP:0002366) | 2.51895550 |
| 29 | Overlapping toe (HP:0001845) | 2.51138102 |
| 30 | Hyperacusis (HP:0010780) | 2.49827754 |
| 31 | Degeneration of anterior horn cells (HP:0002398) | 2.45989991 |
| 32 | Abnormality of the anterior horn cell (HP:0006802) | 2.45989991 |
| 33 | Partial duplication of the phalanx of hand (HP:0009999) | 2.44525753 |
| 34 | Deviation of the thumb (HP:0009603) | 2.43619820 |
| 35 | Oligodactyly (HP:0012165) | 2.43479814 |
| 36 | Duplication of thumb phalanx (HP:0009942) | 2.41571432 |
| 37 | Partial duplication of thumb phalanx (HP:0009944) | 2.41044696 |
| 38 | Ulnar bowing (HP:0003031) | 2.38104535 |
| 39 | Patellar aplasia (HP:0006443) | 2.37042205 |
| 40 | Protrusio acetabuli (HP:0003179) | 2.35070377 |
| 41 | Upper limb amyotrophy (HP:0009129) | 2.32365911 |
| 42 | Distal upper limb amyotrophy (HP:0007149) | 2.32365911 |
| 43 | Increased nuchal translucency (HP:0010880) | 2.32143833 |
| 44 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.28597591 |
| 45 | Long palpebral fissure (HP:0000637) | 2.24552648 |
| 46 | Spinal muscular atrophy (HP:0007269) | 2.23129333 |
| 47 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.22398519 |
| 48 | Broad distal phalanx of finger (HP:0009836) | 2.21902057 |
| 49 | Short 4th metacarpal (HP:0010044) | 2.17507773 |
| 50 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.17507773 |
| 51 | Heterotopia (HP:0002282) | 2.17309902 |
| 52 | Microglossia (HP:0000171) | 2.15663651 |
| 53 | Reticulocytopenia (HP:0001896) | 2.15269021 |
| 54 | Broad thumb (HP:0011304) | 2.14363395 |
| 55 | Capillary hemangiomas (HP:0005306) | 2.14079055 |
| 56 | Shallow orbits (HP:0000586) | 2.12093382 |
| 57 | Neonatal short-limb short stature (HP:0008921) | 2.11764661 |
| 58 | Abnormality of the astrocytes (HP:0100707) | 2.11549307 |
| 59 | Astrocytoma (HP:0009592) | 2.11549307 |
| 60 | Coronal craniosynostosis (HP:0004440) | 2.11548899 |
| 61 | Septate vagina (HP:0001153) | 2.09983466 |
| 62 | Breech presentation (HP:0001623) | 2.09924788 |
| 63 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 2.06958233 |
| 64 | Testicular neoplasm (HP:0010788) | 2.06562465 |
| 65 | Supernumerary spleens (HP:0009799) | 2.04835871 |
| 66 | Turricephaly (HP:0000262) | 2.04045387 |
| 67 | Medulloblastoma (HP:0002885) | 2.04009313 |
| 68 | Cerebral aneurysm (HP:0004944) | 2.02879604 |
| 69 | Sandal gap (HP:0001852) | 2.02506853 |
| 70 | Short humerus (HP:0005792) | 2.02159683 |
| 71 | Aplasia/hypoplasia of the humerus (HP:0006507) | 2.01076881 |
| 72 | Rectal prolapse (HP:0002035) | 1.99809928 |
| 73 | Abnormality of male internal genitalia (HP:0000022) | 1.99549150 |
| 74 | Broad alveolar ridges (HP:0000187) | 1.99077531 |
| 75 | Birth length less than 3rd percentile (HP:0003561) | 1.98964002 |
| 76 | Abnormal number of incisors (HP:0011064) | 1.98086078 |
| 77 | Abnormality of the calcaneus (HP:0008364) | 1.97893670 |
| 78 | Abnormal lung lobation (HP:0002101) | 1.96817065 |
| 79 | Atresia of the external auditory canal (HP:0000413) | 1.95174136 |
| 80 | Ectopic kidney (HP:0000086) | 1.95163608 |
| 81 | Disproportionate tall stature (HP:0001519) | 1.95071212 |
| 82 | Progressive muscle weakness (HP:0003323) | 1.94605700 |
| 83 | Insomnia (HP:0100785) | 1.94361344 |
| 84 | Chromsome breakage (HP:0040012) | 1.93454869 |
| 85 | Osteomalacia (HP:0002749) | 1.92690114 |
| 86 | Pelvic girdle muscle weakness (HP:0003749) | 1.92674945 |
| 87 | High anterior hairline (HP:0009890) | 1.91799384 |
| 88 | Short phalanx of the thumb (HP:0009660) | 1.90524608 |
| 89 | Arnold-Chiari malformation (HP:0002308) | 1.89898336 |
| 90 | Overriding aorta (HP:0002623) | 1.89003319 |
| 91 | Natal tooth (HP:0000695) | 1.88985752 |
| 92 | Glioma (HP:0009733) | 1.87875107 |
| 93 | Broad phalanges of the hand (HP:0009768) | 1.87843857 |
| 94 | Carpal bone hypoplasia (HP:0001498) | 1.87653346 |
| 95 | Rhabdomyosarcoma (HP:0002859) | 1.86010592 |
| 96 | Genu recurvatum (HP:0002816) | 1.85603175 |
| 97 | Abnormality of the musculature of the hand (HP:0001421) | 1.84755566 |
| 98 | Primary amenorrhea (HP:0000786) | 1.83757572 |
| 99 | Difficulty climbing stairs (HP:0003551) | 1.83639828 |
| 100 | Vertebral arch anomaly (HP:0008438) | 1.83514336 |
| 101 | Absent radius (HP:0003974) | 1.82937930 |
| 102 | Abnormality of the salivary glands (HP:0010286) | 1.82509186 |
| 103 | Trismus (HP:0000211) | 1.82501460 |
| 104 | Shoulder girdle muscle weakness (HP:0003547) | 1.82217336 |
| 105 | Deep palmar crease (HP:0006191) | 1.80121329 |
| 106 | Short thumb (HP:0009778) | 1.79800151 |
| 107 | Neoplasm of striated muscle (HP:0009728) | 1.79674004 |
| 108 | Rib fusion (HP:0000902) | 1.79333907 |
| 109 | Upper motor neuron abnormality (HP:0002127) | 1.79287468 |
| 110 | Broad finger (HP:0001500) | 1.78742008 |
| 111 | Spinal rigidity (HP:0003306) | 1.78717801 |
| 112 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.77448926 |
| 113 | Colon cancer (HP:0003003) | 1.77221340 |
| 114 | Broad long bones (HP:0005622) | 1.76983800 |
| 115 | Long eyelashes (HP:0000527) | 1.75200559 |
| 116 | Mitral valve prolapse (HP:0001634) | 1.74872779 |
| 117 | Abnormality of the 1st metacarpal (HP:0010009) | 1.74261106 |
| 118 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.73604731 |
| 119 | Premature rupture of membranes (HP:0001788) | 1.73446747 |
| 120 | Abnormality of the aortic arch (HP:0012303) | 1.73415645 |
| 121 | Uterine leiomyosarcoma (HP:0002891) | 1.71994778 |
| 122 | Leiomyosarcoma (HP:0100243) | 1.71994778 |
| 123 | Wrist flexion contracture (HP:0001239) | 1.71779133 |
| 124 | Facial cleft (HP:0002006) | 1.71677396 |
| 125 | Urethral obstruction (HP:0000796) | 1.70771319 |
| 126 | Papillary thyroid carcinoma (HP:0002895) | 1.70090255 |
| 127 | Bowel diverticulosis (HP:0005222) | 1.69957665 |
| 128 | Aplasia involving forearm bones (HP:0009822) | 1.69613840 |
| 129 | Absent forearm bone (HP:0003953) | 1.69613840 |
| 130 | Mitral regurgitation (HP:0001653) | 1.69343948 |
| 131 | Back pain (HP:0003418) | 1.68866311 |
| 132 | Thin ribs (HP:0000883) | 1.68574338 |
| 133 | Bladder diverticulum (HP:0000015) | 1.68497359 |
| 134 | Aplasia involving bones of the extremities (HP:0009825) | 1.68313878 |
| 135 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.68313878 |
| 136 | Aplasia of the phalanges of the hand (HP:0009802) | 1.68313878 |
| 137 | Short 1st metacarpal (HP:0010034) | 1.67857590 |
| 138 | Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026) | 1.67857590 |
| 139 | Prominent nose (HP:0000448) | 1.67402109 |
| 140 | Abnormality of dentin (HP:0010299) | 1.67092751 |
| 141 | Biliary tract neoplasm (HP:0100574) | 1.66614927 |
| 142 | Abnormality of the 4th metacarpal (HP:0010012) | 1.66380281 |
| 143 | Gastrointestinal carcinoma (HP:0002672) | 1.66321078 |
| 144 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.66321078 |
| 145 | Broad metatarsal (HP:0001783) | 1.65996398 |
| 146 | Slender long bone (HP:0003100) | 1.65958448 |
| 147 | Neoplasm of the oral cavity (HP:0100649) | 1.65808725 |
| 148 | Neoplasm of the pancreas (HP:0002894) | 1.65759752 |
| 149 | Advanced eruption of teeth (HP:0006288) | 1.65758327 |
| 150 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.65362799 |
| 151 | Broad phalanx (HP:0006009) | 1.65045144 |
| 152 | Ankyloglossia (HP:0010296) | 1.64951115 |
| 153 | Renal duplication (HP:0000075) | 1.63940949 |
| 154 | Achilles tendon contracture (HP:0001771) | 1.63582211 |
| 155 | Deviation of the hallux (HP:0010051) | 1.62917303 |
| 156 | Radioulnar synostosis (HP:0002974) | 1.62434219 |
| 157 | Abdominal situs inversus (HP:0003363) | 1.61843260 |
| 158 | Abnormality of abdominal situs (HP:0011620) | 1.61843260 |
| 159 | Bowel incontinence (HP:0002607) | 1.61289566 |
| 160 | Bicornuate uterus (HP:0000813) | 1.61218895 |
| 161 | Germ cell neoplasia (HP:0100728) | 1.59599330 |
| 162 | Short middle phalanx of the 5th finger (HP:0004220) | 1.57572743 |
| 163 | Abnormal large intestine physiology (HP:0012700) | 1.56295606 |
| 164 | Cortical dysplasia (HP:0002539) | 1.55636590 |
| 165 | Hypercortisolism (HP:0001578) | 1.55518429 |
| 166 | Deep philtrum (HP:0002002) | 1.54569856 |
| 167 | Choanal stenosis (HP:0000452) | 1.54429722 |
| 168 | Squamous cell carcinoma (HP:0002860) | 1.53649849 |
| 169 | Skull defect (HP:0001362) | 1.53559659 |
| 170 | Biconcave vertebral bodies (HP:0004586) | 1.53241925 |
| 171 | Renovascular hypertension (HP:0100817) | 1.53137466 |
| 172 | Spinal cord lesions (HP:0100561) | 1.52439262 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDK12 | 4.90807802 |
| 2 | CDC7 | 3.59505780 |
| 3 | LATS1 | 3.25703388 |
| 4 | NEK2 | 2.90649639 |
| 5 | LATS2 | 2.84220409 |
| 6 | WEE1 | 2.71583735 |
| 7 | SMG1 | 2.61589252 |
| 8 | TYRO3 | 2.50719960 |
| 9 | ICK | 2.44901164 |
| 10 | PRKD3 | 2.42639241 |
| 11 | BUB1 | 2.40470329 |
| 12 | TRIB3 | 2.29850539 |
| 13 | STK38L | 2.28370581 |
| 14 | TTK | 2.25347477 |
| 15 | PLK4 | 2.00702045 |
| 16 | PRPF4B | 1.96448877 |
| 17 | CDK7 | 1.93132581 |
| 18 | STK3 | 1.81111282 |
| 19 | PLK1 | 1.79546159 |
| 20 | ACVR1B | 1.78623137 |
| 21 | EEF2K | 1.66486351 |
| 22 | CDK9 | 1.63815694 |
| 23 | BRD4 | 1.60308313 |
| 24 | CDK4 | 1.47123579 |
| 25 | STK24 | 1.43791564 |
| 26 | MOS | 1.43699935 |
| 27 | PDK4 | 1.41588467 |
| 28 | PDK3 | 1.41588467 |
| 29 | MTOR | 1.41517451 |
| 30 | TAOK1 | 1.38535986 |
| 31 | CAMK1G | 1.37896625 |
| 32 | PNCK | 1.34341644 |
| 33 | CHEK2 | 1.33816989 |
| 34 | MAP3K10 | 1.29915778 |
| 35 | SIK1 | 1.26786251 |
| 36 | CHEK1 | 1.22506766 |
| 37 | PDGFRA | 1.20430554 |
| 38 | CDK19 | 1.19835133 |
| 39 | EPHA2 | 1.16800022 |
| 40 | MAP3K13 | 1.16097470 |
| 41 | TSSK6 | 1.15641224 |
| 42 | MELK | 1.15128148 |
| 43 | BRSK2 | 1.14491499 |
| 44 | RIPK1 | 1.13872841 |
| 45 | NME2 | 1.12450127 |
| 46 | IRAK3 | 1.10317517 |
| 47 | CDK8 | 1.03697247 |
| 48 | TAOK2 | 1.02204274 |
| 49 | PAK4 | 1.00928427 |
| 50 | ATR | 1.00830631 |
| 51 | PASK | 0.99580283 |
| 52 | WNK3 | 0.98707412 |
| 53 | FGFR4 | 0.95277981 |
| 54 | AURKB | 0.94631558 |
| 55 | PLK3 | 0.93928165 |
| 56 | KSR2 | 0.91548799 |
| 57 | CLK1 | 0.88497244 |
| 58 | PKN2 | 0.87775569 |
| 59 | TAF1 | 0.87090812 |
| 60 | ATM | 0.86784280 |
| 61 | PBK | 0.85884180 |
| 62 | MAP3K8 | 0.83089904 |
| 63 | DYRK3 | 0.81033548 |
| 64 | STK10 | 0.81013774 |
| 65 | PDK2 | 0.80729629 |
| 66 | CDK2 | 0.80587855 |
| 67 | NTRK1 | 0.79789647 |
| 68 | STK16 | 0.79549795 |
| 69 | TTN | 0.79543705 |
| 70 | PAK2 | 0.78465896 |
| 71 | YES1 | 0.77089433 |
| 72 | MAP3K9 | 0.75207811 |
| 73 | KSR1 | 0.74240607 |
| 74 | RPS6KB2 | 0.71235848 |
| 75 | DMPK | 0.70738673 |
| 76 | MAP3K6 | 0.69207541 |
| 77 | TGFBR1 | 0.68995147 |
| 78 | PTK6 | 0.68536028 |
| 79 | CAMK1D | 0.68507890 |
| 80 | DDR2 | 0.67039965 |
| 81 | NEK9 | 0.66806539 |
| 82 | PTK2 | 0.66229972 |
| 83 | AURKA | 0.66168034 |
| 84 | CDK1 | 0.63888055 |
| 85 | EPHB2 | 0.63636047 |
| 86 | RPS6KA4 | 0.63628958 |
| 87 | MKNK2 | 0.62704472 |
| 88 | STK4 | 0.60991656 |
| 89 | CDK6 | 0.60343759 |
| 90 | ALK | 0.60036475 |
| 91 | BRAF | 0.58609654 |
| 92 | STK38 | 0.58126832 |
| 93 | CDK11A | 0.58107978 |
| 94 | AKT2 | 0.57490541 |
| 95 | MET | 0.56851526 |
| 96 | NEK1 | 0.56823788 |
| 97 | CSNK1A1L | 0.56286904 |
| 98 | MAP2K2 | 0.55628436 |
| 99 | ERBB4 | 0.54823556 |
| 100 | PAK1 | 0.53932551 |
| 101 | BRSK1 | 0.53773031 |
| 102 | PIM1 | 0.51315443 |
| 103 | WNK1 | 0.49507042 |
| 104 | RAF1 | 0.49153336 |
| 105 | DYRK2 | 0.48889968 |
| 106 | RPS6KC1 | 0.47971168 |
| 107 | RPS6KL1 | 0.47971168 |
| 108 | SCYL2 | 0.47529314 |
| 109 | PRKD2 | 0.47458586 |
| 110 | CDK15 | 0.45937390 |
| 111 | ARAF | 0.45909560 |
| 112 | MKNK1 | 0.45206018 |
| 113 | BMX | 0.45154454 |
| 114 | RPS6KA1 | 0.44402311 |
| 115 | CSNK1E | 0.44338535 |
| 116 | CSNK1G1 | 0.43468789 |
| 117 | TESK2 | 0.43266629 |
| 118 | EIF2AK1 | 0.42982705 |
| 119 | IRAK2 | 0.42429260 |
| 120 | PDGFRB | 0.41914619 |
| 121 | RET | 0.41873960 |
| 122 | BMPR2 | 0.41804082 |
| 123 | FGFR1 | 0.40092658 |
| 124 | SRPK1 | 0.37858448 |
| 125 | MAPK1 | 0.37148290 |
| 126 | PRKCI | 0.36208253 |
| 127 | PRKDC | 0.36200931 |
| 128 | TESK1 | 0.35646952 |
| 129 | CHUK | 0.35099945 |
| 130 | MAP3K3 | 0.34767918 |
| 131 | GSK3B | 0.33823525 |
| 132 | TBK1 | 0.33668909 |
| 133 | AKT3 | 0.33309676 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.57814081 |
| 2 | RNA transport_Homo sapiens_hsa03013 | 3.36102892 |
| 3 | Cell cycle_Homo sapiens_hsa04110 | 3.31057878 |
| 4 | Basal transcription factors_Homo sapiens_hsa03022 | 3.11731067 |
| 5 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.56747133 |
| 6 | DNA replication_Homo sapiens_hsa03030 | 2.43403030 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 2.28740053 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 2.27222065 |
| 9 | Oocyte meiosis_Homo sapiens_hsa04114 | 2.23291734 |
| 10 | Mismatch repair_Homo sapiens_hsa03430 | 2.09326442 |
| 11 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 2.08630358 |
| 12 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 2.04830955 |
| 13 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.99062290 |
| 14 | Base excision repair_Homo sapiens_hsa03410 | 1.96186265 |
| 15 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.86781660 |
| 16 | Homologous recombination_Homo sapiens_hsa03440 | 1.73299955 |
| 17 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.73272180 |
| 18 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.72182735 |
| 19 | RNA degradation_Homo sapiens_hsa03018 | 1.71199960 |
| 20 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.70070673 |
| 21 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.69794057 |
| 22 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.68812525 |
| 23 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.67694649 |
| 24 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.51590155 |
| 25 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.49295558 |
| 26 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.47118328 |
| 27 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.45006665 |
| 28 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.43537045 |
| 29 | Adherens junction_Homo sapiens_hsa04520 | 1.40772579 |
| 30 | Ribosome_Homo sapiens_hsa03010 | 1.35356521 |
| 31 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.31206716 |
| 32 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.28955512 |
| 33 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.22495752 |
| 34 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.17982985 |
| 35 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.16260812 |
| 36 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 1.13472153 |
| 37 | HTLV-I infection_Homo sapiens_hsa05166 | 1.13265477 |
| 38 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.12551474 |
| 39 | Lysine degradation_Homo sapiens_hsa00310 | 1.11993465 |
| 40 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.11052344 |
| 41 | Thyroid cancer_Homo sapiens_hsa05216 | 1.10646970 |
| 42 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.09866469 |
| 43 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.08363317 |
| 44 | Tight junction_Homo sapiens_hsa04530 | 1.07657666 |
| 45 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.06389899 |
| 46 | ECM-receptor interaction_Homo sapiens_hsa04512 | 1.05660321 |
| 47 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.04238167 |
| 48 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.02982955 |
| 49 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.01145051 |
| 50 | Colorectal cancer_Homo sapiens_hsa05210 | 1.00213546 |
| 51 | Prostate cancer_Homo sapiens_hsa05215 | 0.96404093 |
| 52 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.95304664 |
| 53 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.93373747 |
| 54 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.92637678 |
| 55 | Prion diseases_Homo sapiens_hsa05020 | 0.89757322 |
| 56 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.88507169 |
| 57 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.88040863 |
| 58 | Focal adhesion_Homo sapiens_hsa04510 | 0.87976502 |
| 59 | Proteasome_Homo sapiens_hsa03050 | 0.86132847 |
| 60 | Sulfur relay system_Homo sapiens_hsa04122 | 0.84897418 |
| 61 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.82866146 |
| 62 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.80672085 |
| 63 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.80387275 |
| 64 | Endometrial cancer_Homo sapiens_hsa05213 | 0.78724104 |
| 65 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.77813829 |
| 66 | Pathways in cancer_Homo sapiens_hsa05200 | 0.77582811 |
| 67 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.77257278 |
| 68 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.75402331 |
| 69 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.74435650 |
| 70 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.74125168 |
| 71 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.71352495 |
| 72 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.71343140 |
| 73 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.71034391 |
| 74 | Bladder cancer_Homo sapiens_hsa05219 | 0.71026171 |
| 75 | Melanogenesis_Homo sapiens_hsa04916 | 0.69695441 |
| 76 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.66667316 |
| 77 | Circadian rhythm_Homo sapiens_hsa04710 | 0.66036639 |
| 78 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.65259076 |
| 79 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.64882594 |
| 80 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.64802495 |
| 81 | Purine metabolism_Homo sapiens_hsa00230 | 0.64633055 |
| 82 | Galactose metabolism_Homo sapiens_hsa00052 | 0.63121228 |
| 83 | Gap junction_Homo sapiens_hsa04540 | 0.63111407 |
| 84 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.63085655 |
| 85 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.63057085 |
| 86 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.61291333 |
| 87 | Amoebiasis_Homo sapiens_hsa05146 | 0.61140791 |
| 88 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.61070021 |
| 89 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.57850831 |
| 90 | Shigellosis_Homo sapiens_hsa05131 | 0.57737243 |
| 91 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.57235159 |
| 92 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.57017998 |
| 93 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.55918505 |
| 94 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.54938886 |
| 95 | Influenza A_Homo sapiens_hsa05164 | 0.54680809 |
| 96 | Viral myocarditis_Homo sapiens_hsa05416 | 0.52127201 |
| 97 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.51489991 |
| 98 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.51142897 |
| 99 | Carbon metabolism_Homo sapiens_hsa01200 | 0.51008681 |
| 100 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.49320530 |
| 101 | Hepatitis B_Homo sapiens_hsa05161 | 0.48440738 |
| 102 | Glioma_Homo sapiens_hsa05214 | 0.48379437 |
| 103 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.48374339 |
| 104 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.48297817 |
| 105 | Mineral absorption_Homo sapiens_hsa04978 | 0.47153052 |
| 106 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.45349652 |
| 107 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.44523045 |
| 108 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.43843414 |
| 109 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.42474918 |
| 110 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.42194763 |
| 111 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.41418870 |
| 112 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.40810973 |
| 113 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.39130274 |
| 114 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.37446103 |
| 115 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.37025927 |
| 116 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.36887729 |
| 117 | Melanoma_Homo sapiens_hsa05218 | 0.36730149 |
| 118 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.36482324 |
| 119 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.36224740 |
| 120 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.35763997 |
| 121 | Apoptosis_Homo sapiens_hsa04210 | 0.34907540 |
| 122 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.33899045 |
| 123 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.33446274 |
| 124 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.33326369 |

