

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA unwinding involved in DNA replication (GO:0006268) | 5.55643807 |
| 2 | protein localization to kinetochore (GO:0034501) | 5.19964027 |
| 3 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.83863645 |
| 4 | DNA strand elongation (GO:0022616) | 4.60035669 |
| 5 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.52916666 |
| 6 | DNA replication initiation (GO:0006270) | 4.44786567 |
| 7 | negative regulation of erythrocyte differentiation (GO:0045647) | 4.44309818 |
| 8 | protein localization to chromosome, centromeric region (GO:0071459) | 4.37444593 |
| 9 | mitotic chromosome condensation (GO:0007076) | 4.30134076 |
| 10 | telomere maintenance via recombination (GO:0000722) | 4.26387099 |
| 11 | mitotic recombination (GO:0006312) | 4.15388571 |
| 12 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.88330633 |
| 13 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.88330633 |
| 14 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.87308141 |
| 15 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.87308141 |
| 16 | DNA replication checkpoint (GO:0000076) | 3.70692783 |
| 17 | mitotic nuclear envelope disassembly (GO:0007077) | 3.69749267 |
| 18 | mitotic sister chromatid cohesion (GO:0007064) | 3.68826272 |
| 19 | sister chromatid segregation (GO:0000819) | 3.67498762 |
| 20 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.66495171 |
| 21 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.64851430 |
| 22 | mitotic sister chromatid segregation (GO:0000070) | 3.64699471 |
| 23 | DNA geometric change (GO:0032392) | 3.61973753 |
| 24 | DNA duplex unwinding (GO:0032508) | 3.61006458 |
| 25 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.59268126 |
| 26 | kinetochore organization (GO:0051383) | 3.57888601 |
| 27 | nuclear pore complex assembly (GO:0051292) | 3.57827926 |
| 28 | telomere maintenance via telomere lengthening (GO:0010833) | 3.53461134 |
| 29 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.52607574 |
| 30 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.44263027 |
| 31 | meiotic chromosome segregation (GO:0045132) | 3.43336173 |
| 32 | nuclear pore organization (GO:0006999) | 3.42702645 |
| 33 | nuclear envelope disassembly (GO:0051081) | 3.42257532 |
| 34 | membrane disassembly (GO:0030397) | 3.42257532 |
| 35 | translesion synthesis (GO:0019985) | 3.41125141 |
| 36 | Golgi transport vesicle coating (GO:0048200) | 3.39277215 |
| 37 | COPI coating of Golgi vesicle (GO:0048205) | 3.39277215 |
| 38 | negative regulation of histone methylation (GO:0031061) | 3.30136990 |
| 39 | mitotic metaphase plate congression (GO:0007080) | 3.27987878 |
| 40 | regulation of histone H3-K9 methylation (GO:0051570) | 3.26623575 |
| 41 | heterochromatin organization (GO:0070828) | 3.26355552 |
| 42 | regulation of RNA export from nucleus (GO:0046831) | 3.24694609 |
| 43 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.20451063 |
| 44 | protein localization to chromosome (GO:0034502) | 3.16382040 |
| 45 | telomere maintenance (GO:0000723) | 3.15669506 |
| 46 | telomere organization (GO:0032200) | 3.11206708 |
| 47 | protein export from nucleus (GO:0006611) | 3.10035008 |
| 48 | metaphase plate congression (GO:0051310) | 3.09899460 |
| 49 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.07122730 |
| 50 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.06282632 |
| 51 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.05921543 |
| 52 | DNA replication-independent nucleosome organization (GO:0034724) | 3.05921543 |
| 53 | DNA conformation change (GO:0071103) | 3.05805514 |
| 54 | ribosomal small subunit biogenesis (GO:0042274) | 3.04793497 |
| 55 | chromatin assembly or disassembly (GO:0006333) | 3.01788423 |
| 56 | establishment of chromosome localization (GO:0051303) | 3.00769021 |
| 57 | IMP biosynthetic process (GO:0006188) | 3.00734953 |
| 58 | DNA topological change (GO:0006265) | 3.00318736 |
| 59 | positive regulation of chromosome segregation (GO:0051984) | 3.00198512 |
| 60 | proline biosynthetic process (GO:0006561) | 2.98198968 |
| 61 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.97303736 |
| 62 | regulation of nucleobase-containing compound transport (GO:0032239) | 2.95608184 |
| 63 | histone phosphorylation (GO:0016572) | 2.92602494 |
| 64 | regulation of spindle organization (GO:0090224) | 2.90113744 |
| 65 | regulation of sister chromatid cohesion (GO:0007063) | 2.89675238 |
| 66 | CENP-A containing nucleosome assembly (GO:0034080) | 2.89296105 |
| 67 | chromatin remodeling at centromere (GO:0031055) | 2.89022645 |
| 68 | chromosome condensation (GO:0030261) | 2.88802310 |
| 69 | regulation of gamma-delta T cell differentiation (GO:0045586) | 2.88223823 |
| 70 | kinetochore assembly (GO:0051382) | 2.87593470 |
| 71 | antigen processing and presentation of endogenous antigen (GO:0019883) | 2.86281282 |
| 72 | regulation of translational fidelity (GO:0006450) | 2.84292971 |
| 73 | negative regulation of gene silencing (GO:0060969) | 2.82418089 |
| 74 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 2.81357711 |
| 75 | positive regulation of DNA-dependent DNA replication (GO:2000105) | 2.80724999 |
| 76 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 2.79748378 |
| 77 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 2.79748378 |
| 78 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 2.78476525 |
| 79 | pore complex assembly (GO:0046931) | 2.78289736 |
| 80 | chromatin assembly (GO:0031497) | 2.75319779 |
| 81 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 2.74190354 |
| 82 | base-excision repair (GO:0006284) | 2.71567064 |
| 83 | negative regulation of RNA splicing (GO:0033119) | 2.71053310 |
| 84 | postreplication repair (GO:0006301) | 2.70514677 |
| 85 | regulation of gamma-delta T cell activation (GO:0046643) | 2.69519651 |
| 86 | positive regulation of gene expression, epigenetic (GO:0045815) | 2.69515565 |
| 87 | IMP metabolic process (GO:0046040) | 2.68776579 |
| 88 | formation of translation preinitiation complex (GO:0001731) | 2.67746962 |
| 89 | nuclear envelope organization (GO:0006998) | 2.67649572 |
| 90 | T cell apoptotic process (GO:0070231) | 2.66592969 |
| 91 | DNA synthesis involved in DNA repair (GO:0000731) | 2.66186157 |
| 92 | chromosome segregation (GO:0007059) | 2.65313199 |
| 93 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.64319988 |
| 94 | regulation of mitotic spindle organization (GO:0060236) | 2.63536892 |
| 95 | regulation of mammary gland epithelial cell proliferation (GO:0033599) | 2.61478938 |
| 96 | regulation of early endosome to late endosome transport (GO:2000641) | 2.60720534 |
| 97 | mismatch repair (GO:0006298) | 2.60406485 |
| 98 | dosage compensation (GO:0007549) | 2.60167530 |
| 99 | somatic diversification of immunoglobulins (GO:0016445) | 2.60124106 |
| 100 | 3-UTR-mediated mRNA stabilization (GO:0070935) | 2.59572654 |
| 101 | ribosomal small subunit assembly (GO:0000028) | 2.59440485 |
| 102 | regulation of translational termination (GO:0006449) | 2.58823388 |
| 103 | regulation of B cell receptor signaling pathway (GO:0050855) | 2.58170042 |
| 104 | regulation of centrosome cycle (GO:0046605) | 2.57611992 |
| 105 | regulation of chromatin silencing (GO:0031935) | 2.57606393 |
| 106 | mRNA stabilization (GO:0048255) | 2.57025561 |
| 107 | RNA stabilization (GO:0043489) | 2.57025561 |
| 108 | nucleobase biosynthetic process (GO:0046112) | 2.56726074 |
| 109 | pentose-phosphate shunt (GO:0006098) | 2.56695983 |
| 110 | negative regulation of mRNA processing (GO:0050686) | 2.56264484 |
| 111 | positive regulation of B cell differentiation (GO:0045579) | 2.55730101 |
| 112 | DNA packaging (GO:0006323) | 2.54866800 |
| 113 | somatic recombination of immunoglobulin gene segments (GO:0016447) | 2.53616570 |
| 114 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 2.52882263 |
| 115 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 2.52882263 |
| 116 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 2.52882263 |
| 117 | B cell receptor signaling pathway (GO:0050853) | 2.52244956 |
| 118 | isotype switching (GO:0045190) | 2.51937727 |
| 119 | regulation of exit from mitosis (GO:0007096) | 2.49331414 |
| 120 | folic acid metabolic process (GO:0046655) | 2.49276586 |
| 121 | mucosal-associated lymphoid tissue development (GO:0048537) | 2.48928690 |
| 122 | Peyers patch development (GO:0048541) | 2.48928690 |
| 123 | modulation by virus of host process (GO:0019054) | 2.46602609 |
| 124 | cellular protein complex localization (GO:0034629) | 2.45621541 |
| 125 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.45294826 |
| 126 | protoporphyrinogen IX metabolic process (GO:0046501) | 2.42753937 |
| 127 | modulation by symbiont of host cellular process (GO:0044068) | 2.42178973 |
| 128 | regulation of chromosome segregation (GO:0051983) | 2.41721545 |
| 129 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 2.40872849 |
| 130 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.40872849 |
| 131 | nucleosome disassembly (GO:0006337) | 2.36012868 |
| 132 | protein-DNA complex disassembly (GO:0032986) | 2.36012868 |
| 133 | pinocytosis (GO:0006907) | 2.34153241 |
| 134 | mitotic nuclear envelope reassembly (GO:0007084) | 2.33635866 |
| 135 | nuclear envelope reassembly (GO:0031468) | 2.33635866 |
| 136 | regulation of histone H3-K4 methylation (GO:0051569) | 2.31198000 |
| 137 | glucocorticoid receptor signaling pathway (GO:0042921) | 2.30988284 |
| 138 | negative regulation of mRNA metabolic process (GO:1903312) | 2.29692684 |
| 139 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.28934588 |
| 140 | * regulation of histone H3-K27 methylation (GO:0061085) | 2.28519477 |
| 141 | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr | 2.28398322 |
| 142 | thymic T cell selection (GO:0045061) | 2.28181057 |
| 143 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 2.27589273 |
| 144 | viral mRNA export from host cell nucleus (GO:0046784) | 2.27455938 |
| 145 | activation of Rac GTPase activity (GO:0032863) | 2.26701657 |
| 146 | establishment of mitotic spindle localization (GO:0040001) | 2.25337170 |
| 147 | spindle organization (GO:0007051) | 2.22822378 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * FOXM1_23109430_ChIP-Seq_U2OS_Human | 5.26263589 |
| 2 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.70284024 |
| 3 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.17455432 |
| 4 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.06987175 |
| 5 | MYC_22102868_ChIP-Seq_BL_Human | 2.86782632 |
| 6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.70703695 |
| 7 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.68744403 |
| 8 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.28066601 |
| 9 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.23890291 |
| 10 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.22261500 |
| 11 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.02439707 |
| 12 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.00524487 |
| 13 | E2F7_22180533_ChIP-Seq_HELA_Human | 11.0030562 |
| 14 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.85696861 |
| 15 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.84445510 |
| 16 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.81383651 |
| 17 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.80174059 |
| 18 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.74664993 |
| 19 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.73142845 |
| 20 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.72386155 |
| 21 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.72055101 |
| 22 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.72020540 |
| 23 | * NCOR1_26117541_ChIP-Seq_K562_Human | 1.65336719 |
| 24 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.64429218 |
| 25 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.61166773 |
| 26 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.60992712 |
| 27 | * LXR_22292898_ChIP-Seq_THP-1_Human | 1.58193208 |
| 28 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.56315575 |
| 29 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.56218529 |
| 30 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.56047807 |
| 31 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.55470262 |
| 32 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.51570061 |
| 33 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.48960587 |
| 34 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.46552028 |
| 35 | MAF_26560356_Chip-Seq_TH1_Human | 1.43862810 |
| 36 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.42794728 |
| 37 | UTX_26944678_Chip-Seq_JUKART_Human | 1.39678647 |
| 38 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.39305366 |
| 39 | * MYB_26560356_Chip-Seq_TH2_Human | 1.39195966 |
| 40 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.38463246 |
| 41 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.37084000 |
| 42 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.36787276 |
| 43 | MYB_26560356_Chip-Seq_TH1_Human | 1.36139227 |
| 44 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.35602059 |
| 45 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.35552659 |
| 46 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.35281665 |
| 47 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.34983135 |
| 48 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.34967504 |
| 49 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.34606295 |
| 50 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.32428977 |
| 51 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.32402421 |
| 52 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.30381241 |
| 53 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.30290361 |
| 54 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.30011107 |
| 55 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.29576466 |
| 56 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.28442886 |
| 57 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.27611861 |
| 58 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.26628485 |
| 59 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.26120116 |
| 60 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.23457795 |
| 61 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.22318527 |
| 62 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.22277269 |
| 63 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.20896859 |
| 64 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.20220905 |
| 65 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.20108570 |
| 66 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.19905501 |
| 67 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.19251057 |
| 68 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.18455820 |
| 69 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.18352776 |
| 70 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.17694841 |
| 71 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.17393539 |
| 72 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.17107892 |
| 73 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.16831636 |
| 74 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.14722405 |
| 75 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.13192996 |
| 76 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.13142508 |
| 77 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.12633930 |
| 78 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.12244926 |
| 79 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.12189218 |
| 80 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.12118416 |
| 81 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.11187156 |
| 82 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.11047372 |
| 83 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.10382407 |
| 84 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.10128843 |
| 85 | * MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.08342493 |
| 86 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.07683892 |
| 87 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.07597002 |
| 88 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.06825873 |
| 89 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.05728416 |
| 90 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.04869605 |
| 91 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.04510952 |
| 92 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.04111086 |
| 93 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.03499480 |
| 94 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.03295247 |
| 95 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.03281113 |
| 96 | MAF_26560356_Chip-Seq_TH2_Human | 1.03011647 |
| 97 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.02854556 |
| 98 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.02850346 |
| 99 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.02170845 |
| 100 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.00639596 |
| 101 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.00379780 |
| 102 | * ATF3_27146783_Chip-Seq_COLON_Human | 1.00155653 |
| 103 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.00110078 |
| 104 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.99774689 |
| 105 | * E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 0.99749503 |
| 106 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.99595898 |
| 107 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.99319585 |
| 108 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.99228549 |
| 109 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.99074879 |
| 110 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.98970194 |
| 111 | * ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.98873072 |
| 112 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 0.98782415 |
| 113 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 0.98597528 |
| 114 | * SPI1_23127762_ChIP-Seq_K562_Human | 0.98154277 |
| 115 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.97559737 |
| 116 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 0.95992573 |
| 117 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.95471725 |
| 118 | GATA1_19941826_ChIP-Seq_K562_Human | 0.95040768 |
| 119 | * GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.93625176 |
| 120 | * GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.93124820 |
| 121 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.90876453 |
| 122 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.88635779 |
| 123 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.85359242 |
| 124 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.85227170 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0010094_abnormal_chromosome_stability | 4.01217966 |
| 2 | MP0003693_abnormal_embryo_hatching | 3.49094263 |
| 3 | MP0008057_abnormal_DNA_replication | 3.41650273 |
| 4 | MP0002877_abnormal_melanocyte_morpholog | 3.36682672 |
| 5 | MP0005451_abnormal_body_composition | 3.32992855 |
| 6 | MP0003111_abnormal_nucleus_morphology | 3.32684744 |
| 7 | MP0003077_abnormal_cell_cycle | 3.06360660 |
| 8 | MP0010352_gastrointestinal_tract_polyps | 2.83801300 |
| 9 | MP0002396_abnormal_hematopoietic_system | 2.73723956 |
| 10 | MP0004957_abnormal_blastocyst_morpholog | 2.73619412 |
| 11 | MP0000685_abnormal_immune_system | 2.37606273 |
| 12 | MP0010307_abnormal_tumor_latency | 2.33442329 |
| 13 | MP0001800_abnormal_humoral_immune | 2.21904611 |
| 14 | MP0001835_abnormal_antigen_presentation | 2.17796640 |
| 15 | MP0003763_abnormal_thymus_physiology | 2.09909503 |
| 16 | MP0004808_abnormal_hematopoietic_stem | 1.98167347 |
| 17 | MP0002398_abnormal_bone_marrow | 1.97510873 |
| 18 | MP0008058_abnormal_DNA_repair | 1.96272396 |
| 19 | MP0005076_abnormal_cell_differentiation | 1.94666532 |
| 20 | MP0000490_abnormal_crypts_of | 1.89703208 |
| 21 | MP0009278_abnormal_bone_marrow | 1.84669750 |
| 22 | MP0002452_abnormal_antigen_presenting | 1.83072239 |
| 23 | MP0000350_abnormal_cell_proliferation | 1.82670357 |
| 24 | MP0004185_abnormal_adipocyte_glucose | 1.81499135 |
| 25 | MP0003705_abnormal_hypodermis_morpholog | 1.75466550 |
| 26 | MP0000689_abnormal_spleen_morphology | 1.74420464 |
| 27 | MP0008007_abnormal_cellular_replicative | 1.74076966 |
| 28 | MP0003303_peritoneal_inflammation | 1.72306687 |
| 29 | MP0005058_abnormal_lysosome_morphology | 1.70147640 |
| 30 | MP0003300_gastrointestinal_ulcer | 1.69564762 |
| 31 | MP0002722_abnormal_immune_system | 1.67920223 |
| 32 | MP0009333_abnormal_splenocyte_physiolog | 1.66796591 |
| 33 | MP0001790_abnormal_immune_system | 1.66790592 |
| 34 | MP0005387_immune_system_phenotype | 1.66790592 |
| 35 | MP0000703_abnormal_thymus_morphology | 1.65921466 |
| 36 | MP0001730_embryonic_growth_arrest | 1.63341632 |
| 37 | MP0002420_abnormal_adaptive_immunity | 1.62786162 |
| 38 | MP0003436_decreased_susceptibility_to | 1.61674444 |
| 39 | MP0002019_abnormal_tumor_incidence | 1.61643192 |
| 40 | MP0004233_abnormal_muscle_weight | 1.59994098 |
| 41 | MP0001819_abnormal_immune_cell | 1.59980769 |
| 42 | MP0002723_abnormal_immune_serum | 1.57410039 |
| 43 | MP0001348_abnormal_lacrimal_gland | 1.54408741 |
| 44 | MP0000716_abnormal_immune_system | 1.54180742 |
| 45 | MP0005671_abnormal_response_to | 1.52450286 |
| 46 | MP0002166_altered_tumor_susceptibility | 1.52357892 |
| 47 | MP0005397_hematopoietic_system_phenotyp | 1.51387344 |
| 48 | MP0001545_abnormal_hematopoietic_system | 1.51387344 |
| 49 | MP0005000_abnormal_immune_tolerance | 1.47562837 |
| 50 | MP0002429_abnormal_blood_cell | 1.46415759 |
| 51 | MP0001873_stomach_inflammation | 1.46310180 |
| 52 | MP0008932_abnormal_embryonic_tissue | 1.45128028 |
| 53 | MP0002405_respiratory_system_inflammati | 1.44618809 |
| 54 | MP0000678_abnormal_parathyroid_gland | 1.43514318 |
| 55 | MP0000569_abnormal_digit_pigmentation | 1.40887502 |
| 56 | MP0008260_abnormal_autophagy | 1.40791706 |
| 57 | MP0002006_tumorigenesis | 1.32591805 |
| 58 | MP0005025_abnormal_response_to | 1.31594823 |
| 59 | MP0005464_abnormal_platelet_physiology | 1.30934379 |
| 60 | MP0010155_abnormal_intestine_physiology | 1.26720570 |
| 61 | MP0008438_abnormal_cutaneous_collagen | 1.25582413 |
| 62 | MP0003566_abnormal_cell_adhesion | 1.25454466 |
| 63 | MP0000313_abnormal_cell_death | 1.25389660 |
| 64 | MP0001697_abnormal_embryo_size | 1.21815139 |
| 65 | MP0004947_skin_inflammation | 1.20271686 |
| 66 | MP0005380_embryogenesis_phenotype | 1.18776498 |
| 67 | MP0001672_abnormal_embryogenesis/_devel | 1.18776498 |
| 68 | MP0002080_prenatal_lethality | 1.17108767 |
| 69 | MP0002419_abnormal_innate_immunity | 1.13460839 |
| 70 | MP0004197_abnormal_fetal_growth/weight/ | 1.13085095 |
| 71 | MP0003448_altered_tumor_morphology | 1.11411151 |
| 72 | MP0001853_heart_inflammation | 1.10390381 |
| 73 | MP0003984_embryonic_growth_retardation | 1.09983712 |
| 74 | MP0002086_abnormal_extraembryonic_tissu | 1.09830327 |
| 75 | MP0000858_altered_metastatic_potential | 1.09382262 |
| 76 | MP0003123_paternal_imprinting | 1.08182852 |
| 77 | MP0002088_abnormal_embryonic_growth/wei | 1.07917053 |
| 78 | MP0005174_abnormal_tail_pigmentation | 1.03517807 |
| 79 | MP0002085_abnormal_embryonic_tissue | 1.02018632 |
| 80 | MP0000465_gastrointestinal_hemorrhage | 1.01030154 |
| 81 | MP0005310_abnormal_salivary_gland | 1.01011977 |
| 82 | MP0005023_abnormal_wound_healing | 0.99409207 |
| 83 | MP0003191_abnormal_cellular_cholesterol | 0.97464322 |
| 84 | MP0009785_altered_susceptibility_to | 0.96000559 |
| 85 | MP0001845_abnormal_inflammatory_respons | 0.95302800 |
| 86 | MP0001661_extended_life_span | 0.94400730 |
| 87 | MP0003866_abnormal_defecation | 0.93888491 |
| 88 | MP0005666_abnormal_adipose_tissue | 0.93824284 |
| 89 | MP0001915_intracranial_hemorrhage | 0.92619795 |
| 90 | MP0009840_abnormal_foam_cell | 0.91957892 |
| 91 | MP0003221_abnormal_cardiomyocyte_apopto | 0.91217891 |
| 92 | MP0008877_abnormal_DNA_methylation | 0.91189485 |
| 93 | MP0005621_abnormal_cell_physiology | 0.90612924 |
| 94 | MP0002084_abnormal_developmental_patter | 0.90519266 |
| 95 | MP0003950_abnormal_plasma_membrane | 0.86943445 |
| 96 | MP0000733_abnormal_muscle_development | 0.85329263 |
| 97 | MP0000477_abnormal_intestine_morphology | 0.84537850 |
| 98 | MP0000358_abnormal_cell_content/ | 0.82875941 |
| 99 | MP0009931_abnormal_skin_appearance | 0.81320596 |
| 100 | MP0005501_abnormal_skin_physiology | 0.79045002 |
| 101 | MP0000371_diluted_coat_color | 0.78719272 |
| 102 | MP0002970_abnormal_white_adipose | 0.76599033 |
| 103 | MP0005623_abnormal_meninges_morphology | 0.75977433 |
| 104 | MP0003786_premature_aging | 0.75636359 |
| 105 | MP0005083_abnormal_biliary_tract | 0.74751272 |
| 106 | MP0002009_preneoplasia | 0.74600103 |
| 107 | MP0005384_cellular_phenotype | 0.73823075 |
| 108 | MP0006054_spinal_hemorrhage | 0.73761462 |
| 109 | MP0009672_abnormal_birth_weight | 0.73726508 |
| 110 | MP0001849_ear_inflammation | 0.72064690 |
| 111 | MP0002148_abnormal_hypersensitivity_rea | 0.71641664 |
| 112 | MP0002933_joint_inflammation | 0.70619847 |
| 113 | MP0000747_muscle_weakness | 0.69799308 |
| 114 | MP0000759_abnormal_skeletal_muscle | 0.69554086 |
| 115 | MP0002060_abnormal_skin_morphology | 0.69416376 |
| 116 | MP0003091_abnormal_cell_migration | 0.66158308 |
| 117 | MP0003121_genomic_imprinting | 0.66107674 |
| 118 | MP0003567_abnormal_fetal_cardiomyocyte | 0.65736715 |
| 119 | MP0006082_CNS_inflammation | 0.63681630 |
| 120 | MP0003453_abnormal_keratinocyte_physiol | 0.62835819 |
| 121 | MP0003172_abnormal_lysosome_physiology | 0.62228065 |
| 122 | MP0001119_abnormal_female_reproductive | 0.60775738 |
| 123 | MP0003656_abnormal_erythrocyte_physiolo | 0.60538735 |
| 124 | MP0000767_abnormal_smooth_muscle | 0.60313774 |
| 125 | MP0000598_abnormal_liver_morphology | 0.59116242 |
| 126 | MP0000015_abnormal_ear_pigmentation | 0.59035324 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormal gallbladder physiology (HP:0012438) | 4.20912060 |
| 2 | Cholecystitis (HP:0001082) | 4.20912060 |
| 3 | Chromsome breakage (HP:0040012) | 3.46664815 |
| 4 | IgM deficiency (HP:0002850) | 3.38762207 |
| 5 | Hypertensive crisis (HP:0100735) | 3.21996166 |
| 6 | Reticulocytosis (HP:0001923) | 3.17733275 |
| 7 | Ankyloglossia (HP:0010296) | 3.14821247 |
| 8 | Abnormality of the fingertips (HP:0001211) | 3.14459675 |
| 9 | Recurrent viral infections (HP:0004429) | 3.13899467 |
| 10 | Birth length less than 3rd percentile (HP:0003561) | 3.13421515 |
| 11 | Selective tooth agenesis (HP:0001592) | 3.04160703 |
| 12 | Abnormality of chromosome stability (HP:0003220) | 3.03762739 |
| 13 | Cellulitis (HP:0100658) | 3.03441087 |
| 14 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.98919958 |
| 15 | Truncus arteriosus (HP:0001660) | 2.87098811 |
| 16 | Reticulocytopenia (HP:0001896) | 2.82466178 |
| 17 | Abnormality of oral frenula (HP:0000190) | 2.81851632 |
| 18 | Abnormality of reticulocytes (HP:0004312) | 2.81706972 |
| 19 | Polycythemia (HP:0001901) | 2.68766184 |
| 20 | Ependymoma (HP:0002888) | 2.67427948 |
| 21 | Insomnia (HP:0100785) | 2.66506682 |
| 22 | Fatigue (HP:0012378) | 2.60934784 |
| 23 | Disproportionate tall stature (HP:0001519) | 2.57458310 |
| 24 | Thrombocytosis (HP:0001894) | 2.56508813 |
| 25 | Agnosia (HP:0010524) | 2.54726596 |
| 26 | Recurrent fungal infections (HP:0002841) | 2.54704013 |
| 27 | Basal cell carcinoma (HP:0002671) | 2.54566036 |
| 28 | IgA deficiency (HP:0002720) | 2.53632591 |
| 29 | Recurrent abscess formation (HP:0002722) | 2.52871041 |
| 30 | Deviation of the thumb (HP:0009603) | 2.52227190 |
| 31 | Proximal placement of thumb (HP:0009623) | 2.51287455 |
| 32 | High pitched voice (HP:0001620) | 2.50982014 |
| 33 | Prominent nose (HP:0000448) | 2.46796524 |
| 34 | Medulloblastoma (HP:0002885) | 2.44181329 |
| 35 | Ectopic kidney (HP:0000086) | 2.43682463 |
| 36 | Increased connective tissue (HP:0009025) | 2.43428499 |
| 37 | Volvulus (HP:0002580) | 2.43308066 |
| 38 | Increased nuchal translucency (HP:0010880) | 2.39009859 |
| 39 | Recurrent bronchitis (HP:0002837) | 2.38871088 |
| 40 | Colon cancer (HP:0003003) | 2.37417894 |
| 41 | Agammaglobulinemia (HP:0004432) | 2.34803956 |
| 42 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 2.34237306 |
| 43 | Abnormality of the tricuspid valve (HP:0001702) | 2.33529600 |
| 44 | T lymphocytopenia (HP:0005403) | 2.32946495 |
| 45 | Hyperthyroidism (HP:0000836) | 2.32503654 |
| 46 | Orthostatic hypotension (HP:0001278) | 2.31082879 |
| 47 | Lymphoma (HP:0002665) | 2.29797467 |
| 48 | Distal lower limb amyotrophy (HP:0008944) | 2.29012002 |
| 49 | Myelodysplasia (HP:0002863) | 2.28603628 |
| 50 | Bowel incontinence (HP:0002607) | 2.27639239 |
| 51 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.26031991 |
| 52 | Abnormal large intestine physiology (HP:0012700) | 2.24847542 |
| 53 | Recurrent bacterial skin infections (HP:0005406) | 2.24598984 |
| 54 | Seborrheic dermatitis (HP:0001051) | 2.24305703 |
| 55 | Abnormality of T cell number (HP:0011839) | 2.23073187 |
| 56 | Mediastinal lymphadenopathy (HP:0100721) | 2.22756212 |
| 57 | Gastrointestinal inflammation (HP:0004386) | 2.22437243 |
| 58 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.21641228 |
| 59 | Short 4th metacarpal (HP:0010044) | 2.21310397 |
| 60 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.21310397 |
| 61 | Progressive muscle weakness (HP:0003323) | 2.21189126 |
| 62 | B lymphocytopenia (HP:0010976) | 2.20471630 |
| 63 | Abnormality of B cell number (HP:0010975) | 2.20471630 |
| 64 | Ileus (HP:0002595) | 2.20421127 |
| 65 | Leukopenia (HP:0001882) | 2.20104754 |
| 66 | Abnormality of T cells (HP:0002843) | 2.17856365 |
| 67 | Inflammation of the large intestine (HP:0002037) | 2.17436649 |
| 68 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.17240063 |
| 69 | Broad face (HP:0000283) | 2.16322646 |
| 70 | Overlapping toe (HP:0001845) | 2.16204900 |
| 71 | Eczematoid dermatitis (HP:0000976) | 2.15937695 |
| 72 | Meningitis (HP:0001287) | 2.14286616 |
| 73 | Colitis (HP:0002583) | 2.13666344 |
| 74 | Lymphopenia (HP:0001888) | 2.12301246 |
| 75 | Panhypogammaglobulinemia (HP:0003139) | 2.11967025 |
| 76 | Verrucae (HP:0200043) | 2.10852884 |
| 77 | Papilloma (HP:0012740) | 2.10852884 |
| 78 | Patellar dislocation (HP:0002999) | 2.10371675 |
| 79 | Cholelithiasis (HP:0001081) | 2.09854124 |
| 80 | Osteomyelitis (HP:0002754) | 2.08991333 |
| 81 | Autoimmune thrombocytopenia (HP:0001973) | 2.08291821 |
| 82 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.07173288 |
| 83 | IgG deficiency (HP:0004315) | 2.06964853 |
| 84 | Increased density of long bones (HP:0006392) | 2.05454650 |
| 85 | Achilles tendon contracture (HP:0001771) | 2.05167991 |
| 86 | Patellar aplasia (HP:0006443) | 2.04589341 |
| 87 | Chronic obstructive pulmonary disease (HP:0006510) | 2.03688388 |
| 88 | Obstructive lung disease (HP:0006536) | 2.03688388 |
| 89 | Rhabdomyosarcoma (HP:0002859) | 2.02159314 |
| 90 | Squamous cell carcinoma (HP:0002860) | 2.02152283 |
| 91 | Abnormal number of incisors (HP:0011064) | 1.98616310 |
| 92 | Meckel diverticulum (HP:0002245) | 1.98179941 |
| 93 | Breast hypoplasia (HP:0003187) | 1.96608841 |
| 94 | Deep palmar crease (HP:0006191) | 1.95707710 |
| 95 | Premature rupture of membranes (HP:0001788) | 1.95702806 |
| 96 | Abnormality of T cell physiology (HP:0011840) | 1.95344005 |
| 97 | Abnormality of the preputium (HP:0100587) | 1.95123131 |
| 98 | Cafe-au-lait spot (HP:0000957) | 1.94810125 |
| 99 | Nonimmune hydrops fetalis (HP:0001790) | 1.94615628 |
| 100 | Poikiloderma (HP:0001029) | 1.94610321 |
| 101 | Flat cornea (HP:0007720) | 1.94469393 |
| 102 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.93971488 |
| 103 | Long palpebral fissure (HP:0000637) | 1.93865682 |
| 104 | Abnormality of DNA repair (HP:0003254) | 1.93378617 |
| 105 | Microvesicular hepatic steatosis (HP:0001414) | 1.92633110 |
| 106 | Abnormality of the calcaneus (HP:0008364) | 1.92252795 |
| 107 | Pustule (HP:0200039) | 1.92055518 |
| 108 | Entropion (HP:0000621) | 1.90379222 |
| 109 | Astrocytoma (HP:0009592) | 1.90225720 |
| 110 | Abnormality of the astrocytes (HP:0100707) | 1.90225720 |
| 111 | Gastrointestinal stroma tumor (HP:0100723) | 1.89754538 |
| 112 | Long eyelashes (HP:0000527) | 1.88682295 |
| 113 | Abnormality of the ileum (HP:0001549) | 1.88662298 |
| 114 | Ulnar bowing (HP:0003031) | 1.88452012 |
| 115 | Absent thumb (HP:0009777) | 1.87763254 |
| 116 | Duplicated collecting system (HP:0000081) | 1.87339016 |
| 117 | Bone marrow hypocellularity (HP:0005528) | 1.87253131 |
| 118 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.86999420 |
| 119 | Recurrent cutaneous fungal infections (HP:0011370) | 1.86999420 |
| 120 | Ragged-red muscle fibers (HP:0003200) | 1.86311394 |
| 121 | Amaurosis fugax (HP:0100576) | 1.86179304 |
| 122 | Combined immunodeficiency (HP:0005387) | 1.86012514 |
| 123 | 11 pairs of ribs (HP:0000878) | 1.85870282 |
| 124 | Pointed chin (HP:0000307) | 1.85716911 |
| 125 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.85662018 |
| 126 | Gastrointestinal dysmotility (HP:0002579) | 1.85211291 |
| 127 | Blepharitis (HP:0000498) | 1.84831889 |
| 128 | Myositis (HP:0100614) | 1.84786010 |
| 129 | Vertebral compression fractures (HP:0002953) | 1.84610966 |
| 130 | Progressive external ophthalmoplegia (HP:0000590) | 1.83768789 |
| 131 | Periodontitis (HP:0000704) | 1.83135805 |
| 132 | Trismus (HP:0000211) | 1.82790083 |
| 133 | Abnormality of glycolysis (HP:0004366) | 1.80973021 |
| 134 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.80527458 |
| 135 | Cutis marmorata (HP:0000965) | 1.79043055 |
| 136 | Abnormal number of erythroid precursors (HP:0012131) | 1.78683023 |
| 137 | Upper limb amyotrophy (HP:0009129) | 1.78632743 |
| 138 | Distal upper limb amyotrophy (HP:0007149) | 1.78632743 |
| 139 | Recurrent lower respiratory tract infections (HP:0002783) | 1.78448307 |
| 140 | Hematochezia (HP:0002573) | 1.77171708 |
| 141 | Abnormality of the renal collecting system (HP:0004742) | 1.77039402 |
| 142 | Vasculitis (HP:0002633) | 1.76565799 |
| 143 | Impulsivity (HP:0100710) | 1.76236760 |
| 144 | Pallor (HP:0000980) | 1.75933360 |
| 145 | Chronic otitis media (HP:0000389) | 1.75728126 |
| 146 | Acute myeloid leukemia (HP:0004808) | 1.75068093 |
| 147 | Hyperacusis (HP:0010780) | 1.74072996 |
| 148 | Deep philtrum (HP:0002002) | 1.73840488 |
| 149 | Hypoparathyroidism (HP:0000829) | 1.73669125 |
| 150 | Flared metaphyses (HP:0003015) | 1.73310584 |
| 151 | Dilatation of the ascending aorta (HP:0005111) | 1.72874956 |
| 152 | Upper limb muscle weakness (HP:0003484) | 1.69471087 |
| 153 | Abnormality of the Achilles tendon (HP:0005109) | 1.67474680 |
| 154 | Protrusio acetabuli (HP:0003179) | 1.67213929 |
| 155 | Abnormality of the gallbladder (HP:0005264) | 1.66731036 |
| 156 | Viral hepatitis (HP:0006562) | 1.65258351 |
| 157 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.64189807 |
| 158 | Myopathic facies (HP:0002058) | 1.62957582 |
| 159 | Abnormal gallbladder morphology (HP:0012437) | 1.62906275 |
| 160 | Osteolytic defects of the hand bones (HP:0009699) | 1.62759543 |
| 161 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.62759543 |
| 162 | Granulocytopenia (HP:0001913) | 1.62744235 |
| 163 | Biconcave vertebral bodies (HP:0004586) | 1.62474272 |
| 164 | Increased IgE level (HP:0003212) | 1.62331390 |
| 165 | Renal duplication (HP:0000075) | 1.61699792 |
| 166 | Dislocated radial head (HP:0003083) | 1.61697190 |
| 167 | Abnormality of the thymus (HP:0000777) | 1.61565423 |
| 168 | Rough bone trabeculation (HP:0100670) | 1.61211692 |
| 169 | Broad distal phalanx of finger (HP:0009836) | 1.59192562 |
| 170 | Metaphyseal cupping (HP:0003021) | 1.58180822 |
| 171 | Atelectasis (HP:0100750) | 1.57917275 |
| 172 | Relative macrocephaly (HP:0004482) | 1.55475373 |
| 173 | Premature skin wrinkling (HP:0100678) | 1.55398678 |
| 174 | Elbow flexion contracture (HP:0002987) | 1.55391640 |
| 175 | Sandal gap (HP:0001852) | 1.55186447 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDC7 | 4.55383409 |
| 2 | PRPF4B | 3.35437910 |
| 3 | MAP4K1 | 3.28620353 |
| 4 | EEF2K | 3.19085117 |
| 5 | CDK12 | 3.12377933 |
| 6 | SMG1 | 2.92180472 |
| 7 | IRAK3 | 2.88681217 |
| 8 | NEK2 | 2.81020886 |
| 9 | ICK | 2.69467732 |
| 10 | PKN2 | 2.61015439 |
| 11 | STK10 | 2.60087571 |
| 12 | MAP3K10 | 2.39839132 |
| 13 | WEE1 | 2.25774575 |
| 14 | RIPK4 | 2.13258818 |
| 15 | BUB1 | 2.07306328 |
| 16 | TRIB3 | 2.03152505 |
| 17 | TTK | 1.87010005 |
| 18 | KSR2 | 1.84157115 |
| 19 | BLK | 1.73527422 |
| 20 | EIF2AK1 | 1.71991725 |
| 21 | ATR | 1.62476160 |
| 22 | JAK3 | 1.61728406 |
| 23 | CDK4 | 1.59953621 |
| 24 | RPS6KA4 | 1.59634832 |
| 25 | LRRK2 | 1.58526214 |
| 26 | SIK1 | 1.50042527 |
| 27 | MAP3K8 | 1.45661404 |
| 28 | ERN1 | 1.41928645 |
| 29 | TYK2 | 1.40517288 |
| 30 | MAP3K13 | 1.39466585 |
| 31 | TAOK2 | 1.36953209 |
| 32 | CSF1R | 1.35864008 |
| 33 | BRD4 | 1.35719979 |
| 34 | TAOK3 | 1.35213024 |
| 35 | TESK2 | 1.32972803 |
| 36 | RPS6KB2 | 1.27478878 |
| 37 | BTK | 1.26338913 |
| 38 | CDK7 | 1.26193976 |
| 39 | PIM1 | 1.24842603 |
| 40 | AURKB | 1.22316565 |
| 41 | FGFR4 | 1.21454006 |
| 42 | CLK1 | 1.20925475 |
| 43 | ACVR1B | 1.19671227 |
| 44 | PLK1 | 1.18412410 |
| 45 | GRK6 | 1.15125635 |
| 46 | ZAP70 | 1.14266166 |
| 47 | PLK4 | 1.13431482 |
| 48 | PASK | 1.13129767 |
| 49 | RAF1 | 1.12446159 |
| 50 | EIF2AK3 | 1.07085783 |
| 51 | STK4 | 1.05742996 |
| 52 | TBK1 | 1.03192322 |
| 53 | SYK | 1.01241664 |
| 54 | TTN | 0.99516465 |
| 55 | CDK6 | 0.99311265 |
| 56 | CCNB1 | 0.99021220 |
| 57 | MELK | 0.98561005 |
| 58 | CHEK1 | 0.98151589 |
| 59 | NME2 | 0.97987407 |
| 60 | MST1R | 0.97445288 |
| 61 | BRAF | 0.96382244 |
| 62 | MAP2K3 | 0.94006289 |
| 63 | CHEK2 | 0.93811459 |
| 64 | STK3 | 0.91509676 |
| 65 | FLT3 | 0.91352177 |
| 66 | SCYL2 | 0.91165018 |
| 67 | ALK | 0.88578193 |
| 68 | MKNK1 | 0.84607560 |
| 69 | PTK6 | 0.83981970 |
| 70 | PAK4 | 0.83058493 |
| 71 | DYRK3 | 0.82383785 |
| 72 | SIK3 | 0.81339992 |
| 73 | KIT | 0.78592936 |
| 74 | TGFBR1 | 0.77970461 |
| 75 | BRSK2 | 0.77321060 |
| 76 | NEK1 | 0.76303210 |
| 77 | ATM | 0.75795603 |
| 78 | PDGFRA | 0.75008539 |
| 79 | PBK | 0.74114706 |
| 80 | BMPR2 | 0.73839332 |
| 81 | MAP3K1 | 0.72673205 |
| 82 | ARAF | 0.70403893 |
| 83 | CDK8 | 0.69933322 |
| 84 | MOS | 0.68731499 |
| 85 | BMX | 0.68106284 |
| 86 | LCK | 0.67680791 |
| 87 | MAPKAPK3 | 0.67253111 |
| 88 | MTOR | 0.67184859 |
| 89 | CDK2 | 0.66928932 |
| 90 | MAP3K14 | 0.66554549 |
| 91 | SRPK1 | 0.66551054 |
| 92 | CDK9 | 0.64715923 |
| 93 | PAK1 | 0.64661264 |
| 94 | HCK | 0.63635490 |
| 95 | TSSK6 | 0.63103842 |
| 96 | TXK | 0.62902973 |
| 97 | IRAK2 | 0.61623096 |
| 98 | EPHB1 | 0.61136549 |
| 99 | IKBKB | 0.59720388 |
| 100 | ITK | 0.58010834 |
| 101 | BRSK1 | 0.57605815 |
| 102 | TNK2 | 0.56947088 |
| 103 | ILK | 0.56189737 |
| 104 | LYN | 0.55517374 |
| 105 | AURKA | 0.55375852 |
| 106 | CHUK | 0.55116653 |
| 107 | VRK2 | 0.53826058 |
| 108 | KSR1 | 0.51629256 |
| 109 | IRAK4 | 0.51416197 |
| 110 | TEC | 0.47927727 |
| 111 | IKBKE | 0.47544357 |
| 112 | CAMK1D | 0.47502096 |
| 113 | HIPK2 | 0.46773622 |
| 114 | MAP3K2 | 0.46162004 |
| 115 | CSK | 0.46039989 |
| 116 | MARK3 | 0.45819131 |
| 117 | TRPM7 | 0.45344540 |
| 118 | CDK1 | 0.44345209 |
| 119 | MAPK11 | 0.44236817 |
| 120 | NEK9 | 0.42657914 |
| 121 | SIK2 | 0.42535983 |
| 122 | RPS6KA6 | 0.41967456 |
| 123 | TESK1 | 0.41714808 |
| 124 | RET | 0.41343939 |
| 125 | MKNK2 | 0.41173178 |
| 126 | TLK1 | 0.39828319 |
| 127 | CDC42BPA | 0.39287865 |
| 128 | PAK2 | 0.38606953 |
| 129 | MST4 | 0.37681250 |
| 130 | LATS1 | 0.37522550 |
| 131 | KDR | 0.37085976 |
| 132 | PDPK1 | 0.36973163 |
| 133 | TAOK1 | 0.35812168 |
| 134 | JAK2 | 0.35518530 |
| 135 | MAPKAPK2 | 0.35420652 |
| 136 | NME1 | 0.33836962 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 5.08436619 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.07104515 |
| 3 | Base excision repair_Homo sapiens_hsa03410 | 3.00072277 |
| 4 | Homologous recombination_Homo sapiens_hsa03440 | 2.85750512 |
| 5 | Cell cycle_Homo sapiens_hsa04110 | 2.73843606 |
| 6 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.58321564 |
| 7 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.48826870 |
| 8 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.24957611 |
| 9 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.20624119 |
| 10 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 2.13918800 |
| 11 | Spliceosome_Homo sapiens_hsa03040 | 2.13727434 |
| 12 | RNA transport_Homo sapiens_hsa03013 | 2.04478989 |
| 13 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.90515123 |
| 14 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.80069442 |
| 15 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.79882262 |
| 16 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.76647491 |
| 17 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.67719428 |
| 18 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.52568824 |
| 19 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.51196106 |
| 20 | Ribosome_Homo sapiens_hsa03010 | 1.50138185 |
| 21 | Other glycan degradation_Homo sapiens_hsa00511 | 1.43678217 |
| 22 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.43167669 |
| 23 | RNA degradation_Homo sapiens_hsa03018 | 1.40499123 |
| 24 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.38167916 |
| 25 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.38080850 |
| 26 | Measles_Homo sapiens_hsa05162 | 1.30530616 |
| 27 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.30215000 |
| 28 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.29903007 |
| 29 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.29901609 |
| 30 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.25305331 |
| 31 | HTLV-I infection_Homo sapiens_hsa05166 | 1.22820075 |
| 32 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.22161036 |
| 33 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.21873233 |
| 34 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.21675330 |
| 35 | Leishmaniasis_Homo sapiens_hsa05140 | 1.17583578 |
| 36 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.13510044 |
| 37 | Apoptosis_Homo sapiens_hsa04210 | 1.12717170 |
| 38 | Glioma_Homo sapiens_hsa05214 | 1.10090798 |
| 39 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.09832786 |
| 40 | Hepatitis B_Homo sapiens_hsa05161 | 1.08927033 |
| 41 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.07385016 |
| 42 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.06349281 |
| 43 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.05843786 |
| 44 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.01888183 |
| 45 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.98856595 |
| 46 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.97747053 |
| 47 | Shigellosis_Homo sapiens_hsa05131 | 0.96502265 |
| 48 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.94066786 |
| 49 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.92141335 |
| 50 | Prion diseases_Homo sapiens_hsa05020 | 0.91702181 |
| 51 | RNA polymerase_Homo sapiens_hsa03020 | 0.90940748 |
| 52 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.90862193 |
| 53 | Carbon metabolism_Homo sapiens_hsa01200 | 0.89926685 |
| 54 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.89852878 |
| 55 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.89363554 |
| 56 | Legionellosis_Homo sapiens_hsa05134 | 0.87607292 |
| 57 | Lysine degradation_Homo sapiens_hsa00310 | 0.86691670 |
| 58 | Influenza A_Homo sapiens_hsa05164 | 0.85325971 |
| 59 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.84826953 |
| 60 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.84440016 |
| 61 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.84402675 |
| 62 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.84312751 |
| 63 | Viral myocarditis_Homo sapiens_hsa05416 | 0.83304952 |
| 64 | Colorectal cancer_Homo sapiens_hsa05210 | 0.82357744 |
| 65 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.82125838 |
| 66 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.79981940 |
| 67 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.78648547 |
| 68 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.77950131 |
| 69 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.75158814 |
| 70 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.74036837 |
| 71 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.73721698 |
| 72 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.68885991 |
| 73 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.67755228 |
| 74 | Galactose metabolism_Homo sapiens_hsa00052 | 0.66214296 |
| 75 | Basal transcription factors_Homo sapiens_hsa03022 | 0.66180349 |
| 76 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.65071451 |
| 77 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.64265600 |
| 78 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.64239200 |
| 79 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.64205126 |
| 80 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.64165556 |
| 81 | Prostate cancer_Homo sapiens_hsa05215 | 0.62665367 |
| 82 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.62108713 |
| 83 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.59743839 |
| 84 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.58686813 |
| 85 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.55526637 |
| 86 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.53949398 |
| 87 | Sulfur relay system_Homo sapiens_hsa04122 | 0.53737303 |
| 88 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.52844169 |
| 89 | Tuberculosis_Homo sapiens_hsa05152 | 0.52092938 |
| 90 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.50677694 |
| 91 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.50674671 |
| 92 | Salmonella infection_Homo sapiens_hsa05132 | 0.50212122 |
| 93 | Bladder cancer_Homo sapiens_hsa05219 | 0.50203652 |
| 94 | Focal adhesion_Homo sapiens_hsa04510 | 0.49946909 |
| 95 | Thyroid cancer_Homo sapiens_hsa05216 | 0.49618433 |
| 96 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.49533290 |
| 97 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.49339855 |
| 98 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.48551082 |
| 99 | Hepatitis C_Homo sapiens_hsa05160 | 0.48517518 |
| 100 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.47589314 |
| 101 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.47423101 |
| 102 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.44435396 |
| 103 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.44378700 |
| 104 | Platelet activation_Homo sapiens_hsa04611 | 0.44034164 |
| 105 | Alcoholism_Homo sapiens_hsa05034 | 0.43619775 |
| 106 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.43614653 |
| 107 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.42650620 |
| 108 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.42198476 |
| 109 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.42164989 |
| 110 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.40931031 |
| 111 | Asthma_Homo sapiens_hsa05310 | 0.40368458 |
| 112 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.40317191 |
| 113 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.39742514 |
| 114 | Allograft rejection_Homo sapiens_hsa05330 | 0.39702444 |
| 115 | Endometrial cancer_Homo sapiens_hsa05213 | 0.39070508 |
| 116 | Proteasome_Homo sapiens_hsa03050 | 0.38852582 |
| 117 | Pertussis_Homo sapiens_hsa05133 | 0.37182678 |
| 118 | Purine metabolism_Homo sapiens_hsa00230 | 0.36868642 |
| 119 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.36749691 |
| 120 | Pathways in cancer_Homo sapiens_hsa05200 | 0.34994724 |
| 121 | Malaria_Homo sapiens_hsa05144 | 0.34836252 |
| 122 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.34730466 |
| 123 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.34449536 |
| 124 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.34115147 |

