PHF20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.83302964
2replication fork processing (GO:0031297)4.07211332
3chromatin remodeling at centromere (GO:0031055)3.77318792
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.74262044
5mitotic sister chromatid cohesion (GO:0007064)3.70467054
6exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.66640464
7nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.62680706
8protein neddylation (GO:0045116)3.61756812
9DNA deamination (GO:0045006)3.58732498
10CENP-A containing nucleosome assembly (GO:0034080)3.52949879
11regulation of mitotic spindle checkpoint (GO:1903504)3.52486519
12regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.52486519
13negative regulation of DNA-dependent DNA replication (GO:2000104)3.50837883
14neuron cell-cell adhesion (GO:0007158)3.50627167
15protein complex biogenesis (GO:0070271)3.46223371
16mitochondrial respiratory chain complex assembly (GO:0033108)3.43382905
17regulation of meiosis I (GO:0060631)3.34778774
18establishment of protein localization to mitochondrial membrane (GO:0090151)3.34286530
19protein-cofactor linkage (GO:0018065)3.30754895
20neural tube formation (GO:0001841)3.28915928
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.27948307
22NADH dehydrogenase complex assembly (GO:0010257)3.27948307
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.27948307
24maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.21963711
25histone exchange (GO:0043486)3.21324665
26DNA catabolic process, exonucleolytic (GO:0000738)3.20505065
27RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.16645328
28negative regulation of DNA recombination (GO:0045910)3.15981574
29proteasome assembly (GO:0043248)3.15537582
30piRNA metabolic process (GO:0034587)3.14768277
31protein prenylation (GO:0018342)3.14599220
32prenylation (GO:0097354)3.14599220
33centriole replication (GO:0007099)3.14306603
34RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12677973
35tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12677973
36energy coupled proton transport, down electrochemical gradient (GO:0015985)3.11339948
37ATP synthesis coupled proton transport (GO:0015986)3.11339948
38protein localization to synapse (GO:0035418)3.07952272
39single strand break repair (GO:0000012)3.05977599
40synaptic vesicle endocytosis (GO:0048488)3.04782034
41synaptic vesicle exocytosis (GO:0016079)2.95517454
42kinetochore assembly (GO:0051382)2.95303370
43positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.94130263
44telomere maintenance via telomerase (GO:0007004)2.93012033
45respiratory chain complex IV assembly (GO:0008535)2.89973359
46positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.87300969
47regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.87190930
48recombinational repair (GO:0000725)2.81581483
49negative regulation of translation, ncRNA-mediated (GO:0040033)2.80453429
50regulation of translation, ncRNA-mediated (GO:0045974)2.80453429
51negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.80453429
52peptidyl-histidine modification (GO:0018202)2.80344762
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.80107757
54intra-S DNA damage checkpoint (GO:0031573)2.79848367
55double-strand break repair via homologous recombination (GO:0000724)2.79453167
56negative regulation of meiosis (GO:0045835)2.78936512
57mitotic metaphase plate congression (GO:0007080)2.78621481
58DNA methylation involved in gamete generation (GO:0043046)2.75918256
59anterograde synaptic vesicle transport (GO:0048490)2.75495948
60regulation of relaxation of muscle (GO:1901077)2.75430929
61regulation of DNA methylation (GO:0044030)2.75264570
62IMP biosynthetic process (GO:0006188)2.73383410
63DNA-dependent DNA replication (GO:0006261)2.72888823
64rRNA modification (GO:0000154)2.72564696
65regulation of telomere maintenance (GO:0032204)2.72168627
66regulation of DNA endoreduplication (GO:0032875)2.71552192
67mitotic G2/M transition checkpoint (GO:0044818)2.71425320
68vocalization behavior (GO:0071625)2.71404466
69cell migration in hindbrain (GO:0021535)2.70572310
70DNA replication-independent nucleosome organization (GO:0034724)2.69635917
71DNA replication-independent nucleosome assembly (GO:0006336)2.69635917
72postreplication repair (GO:0006301)2.69173023
73DNA strand renaturation (GO:0000733)2.68337525
74histone mRNA metabolic process (GO:0008334)2.66108248
75DNA ligation (GO:0006266)2.65865132
76synapsis (GO:0007129)2.65091624
77inner mitochondrial membrane organization (GO:0007007)2.64491117
78regulation of nuclear cell cycle DNA replication (GO:0033262)2.64295338
79metaphase plate congression (GO:0051310)2.64154670
80neuron recognition (GO:0008038)2.64064853
81cytochrome complex assembly (GO:0017004)2.63729804
82double-strand break repair via nonhomologous end joining (GO:0006303)2.62292770
83non-recombinational repair (GO:0000726)2.62292770
84inositol phosphate catabolic process (GO:0071545)2.60703207
85somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.60181927
86isotype switching (GO:0045190)2.60181927
87somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.60181927
88sister chromatid cohesion (GO:0007062)2.59368377
89ubiquinone biosynthetic process (GO:0006744)2.58583578
90DNA demethylation (GO:0080111)2.57709888
91glutamate receptor signaling pathway (GO:0007215)2.57368143
92histone arginine methylation (GO:0034969)2.57303735
93platelet dense granule organization (GO:0060155)2.57168637
94presynaptic membrane assembly (GO:0097105)2.57062518
95postsynaptic membrane organization (GO:0001941)2.56705267
96regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.56540277
97nuclear pore complex assembly (GO:0051292)2.56226942
98negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.55627698
99nuclear pore organization (GO:0006999)2.53891795
100regulation of helicase activity (GO:0051095)2.52772964
101layer formation in cerebral cortex (GO:0021819)2.52735770
102regulation of mitochondrial translation (GO:0070129)2.52484482
103regulation of short-term neuronal synaptic plasticity (GO:0048172)2.51608464
104nucleotide-excision repair, DNA gap filling (GO:0006297)2.51531315
105regulation of synaptic vesicle exocytosis (GO:2000300)2.50078667
106regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.49832243
107axonal fasciculation (GO:0007413)2.48751355
108histone H2A acetylation (GO:0043968)2.48253464
109regulation of glucokinase activity (GO:0033131)2.48079634
110regulation of hexokinase activity (GO:1903299)2.48079634
111positive regulation of synapse maturation (GO:0090129)2.47727233
112gamma-aminobutyric acid signaling pathway (GO:0007214)2.47198505
113pseudouridine synthesis (GO:0001522)2.46870397
114G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.46512101
115glutamate secretion (GO:0014047)2.45846446
116mitochondrial DNA replication (GO:0006264)2.44672903
117attachment of spindle microtubules to kinetochore (GO:0008608)2.44567407
118positive regulation of meiosis (GO:0045836)2.44097251
119presynaptic membrane organization (GO:0097090)2.44004906
120regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.43930433
121regulation of glutamate receptor signaling pathway (GO:1900449)2.43594313
122cerebral cortex radially oriented cell migration (GO:0021799)2.42485255
123transmission of nerve impulse (GO:0019226)2.42287134
124synaptic transmission, glutamatergic (GO:0035249)2.42022000
125ionotropic glutamate receptor signaling pathway (GO:0035235)2.41804714
126neuron-neuron synaptic transmission (GO:0007270)2.41765035
127dendrite development (GO:0016358)2.41202628
128establishment of integrated proviral latency (GO:0075713)2.39194817
129microtubule depolymerization (GO:0007019)2.38265244
130locomotory exploration behavior (GO:0035641)2.37815358
131protein deneddylation (GO:0000338)2.36235585
132establishment of chromosome localization (GO:0051303)2.35835953
133meiotic chromosome segregation (GO:0045132)2.35635298
134regulation of meiosis (GO:0040020)2.35516608
135cullin deneddylation (GO:0010388)2.34010320
136maturation of 5.8S rRNA (GO:0000460)2.33904478
137regulation of gene silencing by RNA (GO:0060966)2.33803579
138regulation of posttranscriptional gene silencing (GO:0060147)2.33803579
139regulation of gene silencing by miRNA (GO:0060964)2.33803579
140mitotic sister chromatid segregation (GO:0000070)2.33541857
141innervation (GO:0060384)2.30829001
142microtubule polymerization or depolymerization (GO:0031109)2.30178720
143positive regulation of cellular response to oxidative stress (GO:1900409)2.29783767
144positive regulation of response to oxidative stress (GO:1902884)2.29783767
145regulation of centriole replication (GO:0046599)2.29106527
146male meiosis (GO:0007140)2.28400383
147somatic diversification of immune receptors via somatic mutation (GO:0002566)2.28027991
148somatic hypermutation of immunoglobulin genes (GO:0016446)2.28027991
149regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.27053243
150regulation of synaptic vesicle transport (GO:1902803)2.26195308
151spindle checkpoint (GO:0031577)2.23890414
152mitotic chromosome condensation (GO:0007076)2.22434284
153regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.22085706
154histone H4-K12 acetylation (GO:0043983)2.22068588
155DNA replication initiation (GO:0006270)2.21880770
156establishment of mitochondrion localization (GO:0051654)2.21507798
157negative regulation of histone methylation (GO:0031061)2.20460786
158neuronal action potential propagation (GO:0019227)2.20422507
159positive regulation of dendritic spine morphogenesis (GO:0061003)2.20221423
160negative regulation of synaptic transmission, GABAergic (GO:0032229)2.19239704
161negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.18060026
162exploration behavior (GO:0035640)2.17566887
163mitotic spindle checkpoint (GO:0071174)2.17548273
164DNA replication checkpoint (GO:0000076)2.16945691
165positive regulation of meiotic cell cycle (GO:0051446)2.16504144
166dendritic spine morphogenesis (GO:0060997)2.15033727
167kinetochore organization (GO:0051383)2.14259590
168negative regulation of chromosome segregation (GO:0051985)2.13781749
169female gamete generation (GO:0007292)2.13313534
170peptidyl-arginine omega-N-methylation (GO:0035247)2.12495534
171negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.12013686
172negative regulation of sister chromatid segregation (GO:0033046)2.12013686
173negative regulation of mitotic sister chromatid separation (GO:2000816)2.12013686
174negative regulation of mitotic sister chromatid segregation (GO:0033048)2.12013686
175DNA replication-dependent nucleosome organization (GO:0034723)2.11727221
176DNA replication-dependent nucleosome assembly (GO:0006335)2.11727221
177protein K6-linked ubiquitination (GO:0085020)2.11659434
178DNA alkylation (GO:0006305)2.11470484
179DNA methylation (GO:0006306)2.11470484
180regulation of mitotic sister chromatid separation (GO:0010965)2.11196192
181regulation of mitotic sister chromatid segregation (GO:0033047)2.11196192
182regulation of sister chromatid segregation (GO:0033045)2.11196192
183protein polyglutamylation (GO:0018095)2.10960473
184synaptic vesicle docking involved in exocytosis (GO:0016081)2.10812494
185DNA unwinding involved in DNA replication (GO:0006268)2.10494198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.30553296
2EZH2_22144423_ChIP-Seq_EOC_Human3.58061945
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.21437463
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.92230754
5GBX2_23144817_ChIP-Seq_PC3_Human2.74388075
6ELK1_19687146_ChIP-ChIP_HELA_Human2.70716877
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57403560
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.34372619
9FUS_26573619_Chip-Seq_HEK293_Human2.19838392
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18638795
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.11783117
12VDR_23849224_ChIP-Seq_CD4+_Human2.09108789
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99543978
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97533558
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95528108
16E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94153145
17FOXP3_21729870_ChIP-Seq_TREG_Human1.86395492
18PADI4_21655091_ChIP-ChIP_MCF-7_Human1.86305605
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85827537
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85749787
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.80290733
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80088019
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75640157
24SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.73987384
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68637190
26EWS_26573619_Chip-Seq_HEK293_Human1.66594371
27FOXM1_23109430_ChIP-Seq_U2OS_Human1.66207434
28TAF15_26573619_Chip-Seq_HEK293_Human1.66038993
29MYC_18940864_ChIP-ChIP_HL60_Human1.64003729
30* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60817300
31IGF1R_20145208_ChIP-Seq_DFB_Human1.57685206
32REST_21632747_ChIP-Seq_MESCs_Mouse1.56930211
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56349004
34RNF2_27304074_Chip-Seq_NSC_Mouse1.54897551
35* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54159473
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.51524763
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49765223
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49173015
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48014623
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48014623
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48014623
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46951362
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46119125
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46049640
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43830387
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40306014
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39097553
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38877562
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38312598
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.38099898
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37765358
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36539282
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33395119
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.32355193
55ER_23166858_ChIP-Seq_MCF-7_Human1.32058228
56* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31903775
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.31117674
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27697383
59* SMAD4_21799915_ChIP-Seq_A2780_Human1.27636783
60P300_19829295_ChIP-Seq_ESCs_Human1.24715383
61* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23776202
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.23258799
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22028719
64STAT3_23295773_ChIP-Seq_U87_Human1.21905911
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20819425
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20562281
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.20261002
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19391174
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18820037
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18613624
71* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18370190
72SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18363924
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17424200
74SOX2_16153702_ChIP-ChIP_HESCs_Human1.17085517
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16022107
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15529320
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.13641000
78MYC_18555785_ChIP-Seq_MESCs_Mouse1.13406842
79EST1_17652178_ChIP-ChIP_JURKAT_Human1.13311192
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13280010
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.11708641
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11411246
83NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.10796660
84* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10659849
85HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10538559
86STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10123176
87CBP_20019798_ChIP-Seq_JUKART_Human1.09940626
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09940626
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09908287
90SOX9_26525672_Chip-Seq_HEART_Mouse1.09844279
91ZNF274_21170338_ChIP-Seq_K562_Hela1.09032604
92TP53_22573176_ChIP-Seq_HFKS_Human1.08704231
93POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08681215
94MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08333411
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07703535
96VDR_22108803_ChIP-Seq_LS180_Human1.07123828
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06820121
98NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.06818150
99* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06443970
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05468861
101FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05453132
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05448344
103EZH2_27304074_Chip-Seq_ESCs_Mouse1.04785651
104EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04696609
105JUN_21703547_ChIP-Seq_K562_Human1.04591481
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04533366
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04301727
108* TCF4_23295773_ChIP-Seq_U87_Human1.03871139
109RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02408230
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01662953
111KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01610226
112SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00953462
113FLI1_27457419_Chip-Seq_LIVER_Mouse1.00371866
114AR_25329375_ChIP-Seq_VCAP_Human1.00333634
115SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00163679
116POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99812042
117CBX2_27304074_Chip-Seq_ESCs_Mouse0.99559370
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98432171
119* NANOG_18555785_Chip-Seq_ESCs_Mouse0.98422572
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98066573
121TP63_19390658_ChIP-ChIP_HaCaT_Human0.98004527
122* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97896939
123PIAS1_25552417_ChIP-Seq_VCAP_Human0.97404166
124PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97057887
125NANOG_16153702_ChIP-ChIP_HESCs_Human0.96857281
126* BCAT_22108803_ChIP-Seq_LS180_Human0.96289183
127MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96153107
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96101210
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96101210
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96022194
131* E2F1_21310950_ChIP-Seq_MCF-7_Human0.95606542
132GABP_19822575_ChIP-Seq_HepG2_Human0.95130913
133HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94791491
134STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94646980
135* E2F1_18555785_Chip-Seq_ESCs_Mouse0.94416072
136KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94408916
137* P53_22387025_ChIP-Seq_ESCs_Mouse0.94397688
138CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94185494
139SMAD3_21741376_ChIP-Seq_EPCs_Human0.94178292
140YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94067808
141TCF3_18692474_ChIP-Seq_MESCs_Mouse0.94021333
142* P300_18555785_Chip-Seq_ESCs_Mouse0.94009229
143IRF1_19129219_ChIP-ChIP_H3396_Human0.93407842
144FOXA1_25329375_ChIP-Seq_VCAP_Human0.93345291
145FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93345291
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92954042
147RNF2_27304074_Chip-Seq_ESCs_Mouse0.92864652
148TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.92699082
149SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92500285
150POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92407221
151EZH2_18974828_ChIP-Seq_MESCs_Mouse0.91803224
152RNF2_18974828_ChIP-Seq_MESCs_Mouse0.91803224
153POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91026620

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.30089340
2MP0004859_abnormal_synaptic_plasticity3.17715986
3MP0008877_abnormal_DNA_methylation3.15811763
4MP0003787_abnormal_imprinting2.68959969
5MP0004270_analgesia2.66809361
6MP0003635_abnormal_synaptic_transmissio2.28807879
7MP0003121_genomic_imprinting2.22926421
8MP0000372_irregular_coat_pigmentation2.17283216
9MP0003123_paternal_imprinting2.14751165
10MP0006292_abnormal_olfactory_placode2.02328420
11MP0002734_abnormal_mechanical_nocicepti1.96659910
12MP0008057_abnormal_DNA_replication1.95881398
13MP0002063_abnormal_learning/memory/cond1.95867508
14MP0000778_abnormal_nervous_system1.95526133
15MP0009046_muscle_twitch1.94596761
16MP0001968_abnormal_touch/_nociception1.93314805
17MP0005075_abnormal_melanosome_morpholog1.92653168
18MP0001188_hyperpigmentation1.86943191
19MP0010094_abnormal_chromosome_stability1.86501392
20MP0009745_abnormal_behavioral_response1.84950782
21MP0002572_abnormal_emotion/affect_behav1.80340170
22MP0003646_muscle_fatigue1.79885901
23MP0002736_abnormal_nociception_after1.76251558
24MP0009697_abnormal_copulation1.75845365
25MP0002735_abnormal_chemical_nociception1.73584761
26MP0001529_abnormal_vocalization1.68761360
27MP0002064_seizures1.67320383
28MP0002272_abnormal_nervous_system1.66131393
29MP0005174_abnormal_tail_pigmentation1.65938091
30MP0002184_abnormal_innervation1.63906959
31MP0003122_maternal_imprinting1.63857560
32MP0003786_premature_aging1.62476951
33MP0000427_abnormal_hair_cycle1.59471177
34MP0005423_abnormal_somatic_nervous1.58382974
35MP0001486_abnormal_startle_reflex1.56547592
36MP0002653_abnormal_ependyma_morphology1.54979693
37MP0003111_abnormal_nucleus_morphology1.48656537
38MP0008058_abnormal_DNA_repair1.44366206
39MP0008995_early_reproductive_senescence1.44344382
40MP0001293_anophthalmia1.44158442
41MP0004957_abnormal_blastocyst_morpholog1.43280783
42MP0001905_abnormal_dopamine_level1.40135606
43MP0003077_abnormal_cell_cycle1.39781407
44MP0006276_abnormal_autonomic_nervous1.39095208
45MP0002067_abnormal_sensory_capabilities1.36368832
46MP0002938_white_spotting1.35172504
47MP0001440_abnormal_grooming_behavior1.31628761
48MP0005367_renal/urinary_system_phenotyp1.30820731
49MP0000516_abnormal_urinary_system1.30820731
50MP0004885_abnormal_endolymph1.29373545
51MP0003567_abnormal_fetal_cardiomyocyte1.28934155
52MP0006072_abnormal_retinal_apoptosis1.28896217
53MP0003136_yellow_coat_color1.28079078
54MP0000955_abnormal_spinal_cord1.27709521
55MP0002733_abnormal_thermal_nociception1.26344267
56MP0008932_abnormal_embryonic_tissue1.25730066
57MP0002557_abnormal_social/conspecific_i1.24870709
58MP0001485_abnormal_pinna_reflex1.23819308
59MP0005645_abnormal_hypothalamus_physiol1.23480151
60MP0002882_abnormal_neuron_morphology1.21718947
61MP0003861_abnormal_nervous_system1.20342271
62MP0004811_abnormal_neuron_physiology1.20116697
63MP0002102_abnormal_ear_morphology1.19817689
64MP0001970_abnormal_pain_threshold1.19052711
65MP0003890_abnormal_embryonic-extraembry1.18914913
66MP0002152_abnormal_brain_morphology1.17489829
67MP0003806_abnormal_nucleotide_metabolis1.17460569
68MP0003632_abnormal_nervous_system1.17447099
69MP0002095_abnormal_skin_pigmentation1.16614207
70MP0002837_dystrophic_cardiac_calcinosis1.16609933
71MP0004145_abnormal_muscle_electrophysio1.15207217
72MP0003693_abnormal_embryo_hatching1.15027222
73MP0005499_abnormal_olfactory_system1.14684484
74MP0005394_taste/olfaction_phenotype1.14684484
75MP0005386_behavior/neurological_phenoty1.14033696
76MP0004924_abnormal_behavior1.14033696
77MP0000631_abnormal_neuroendocrine_gland1.12673987
78MP0003011_delayed_dark_adaptation1.10728788
79MP0004142_abnormal_muscle_tone1.10478960
80MP0003315_abnormal_perineum_morphology1.08486892
81MP0002210_abnormal_sex_determination1.08409011
82MP0001984_abnormal_olfaction1.05429628
83MP0003718_maternal_effect1.04611199
84MP0005623_abnormal_meninges_morphology1.03607897
85MP0004133_heterotaxia1.02896497
86MP0004742_abnormal_vestibular_system1.01181040
87MP0000569_abnormal_digit_pigmentation1.00968798
88MP0005171_absent_coat_pigmentation1.00444166
89MP0003937_abnormal_limbs/digits/tail_de1.00120965
90MP0006035_abnormal_mitochondrial_morpho1.00023373
91MP0008007_abnormal_cellular_replicative0.98879606
92MP0005389_reproductive_system_phenotype0.98763677
93MP0002234_abnormal_pharynx_morphology0.96596815
94MP0002752_abnormal_somatic_nervous0.96341122
95MP0002066_abnormal_motor_capabilities/c0.95857964
96MP0003186_abnormal_redox_activity0.95600169
97MP0001929_abnormal_gametogenesis0.95475834
98MP0001919_abnormal_reproductive_system0.94766747
99MP0002396_abnormal_hematopoietic_system0.94086239
100MP0001286_abnormal_eye_development0.93592750
101MP0002751_abnormal_autonomic_nervous0.92223591
102MP0005646_abnormal_pituitary_gland0.90545590
103MP0000371_diluted_coat_color0.89737760
104MP0001963_abnormal_hearing_physiology0.89662615
105MP0003698_abnormal_male_reproductive0.89341568
106MP0000653_abnormal_sex_gland0.89185594
107MP0000015_abnormal_ear_pigmentation0.89152769
108MP0005408_hypopigmentation0.89117512
109MP0002084_abnormal_developmental_patter0.88740345
110MP0001324_abnormal_eye_pigmentation0.88679769
111MP0001145_abnormal_male_reproductive0.88469395
112MP0008789_abnormal_olfactory_epithelium0.87388228
113MP0001501_abnormal_sleep_pattern0.86995001
114MP0008872_abnormal_physiological_respon0.85628264
115MP0003938_abnormal_ear_development0.85149773
116MP0002085_abnormal_embryonic_tissue0.84908540
117MP0003119_abnormal_digestive_system0.84069448
118MP0000647_abnormal_sebaceous_gland0.83589648
119MP0002277_abnormal_respiratory_mucosa0.83570877
120MP0004858_abnormal_nervous_system0.83476486
121MP0002160_abnormal_reproductive_system0.83141124
122MP0003755_abnormal_palate_morphology0.82549842
123MP0002638_abnormal_pupillary_reflex0.81799933
124MP0006036_abnormal_mitochondrial_physio0.81479193
125MP0004381_abnormal_hair_follicle0.81443789
126MP0002229_neurodegeneration0.80688159
127MP0001730_embryonic_growth_arrest0.79506426
128MP0000350_abnormal_cell_proliferation0.79244034
129MP0001986_abnormal_taste_sensitivity0.79109396
130MP0005084_abnormal_gallbladder_morpholo0.78716098
131MP0009703_decreased_birth_body0.77507414
132MP0003950_abnormal_plasma_membrane0.77286368
133MP0003631_nervous_system_phenotype0.75958036
134MP0005551_abnormal_eye_electrophysiolog0.75595589
135MP0002163_abnormal_gland_morphology0.75379197
136MP0008569_lethality_at_weaning0.73953259
137MP0005253_abnormal_eye_physiology0.73929890
138MP0001177_atelectasis0.68857762
139MP0004215_abnormal_myocardial_fiber0.68797918
140MP0002928_abnormal_bile_duct0.68148992
141MP0001697_abnormal_embryo_size0.66685856

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.05196165
2Focal motor seizures (HP:0011153)3.17670392
3Colon cancer (HP:0003003)3.14435780
4Pancreatic cysts (HP:0001737)3.01595799
5Pancreatic fibrosis (HP:0100732)3.00548824
6Acute necrotizing encephalopathy (HP:0006965)2.99760453
7Molar tooth sign on MRI (HP:0002419)2.97048730
8Abnormality of midbrain morphology (HP:0002418)2.97048730
9Atonic seizures (HP:0010819)2.93289369
10Increased hepatocellular lipid droplets (HP:0006565)2.91735364
113-Methylglutaconic aciduria (HP:0003535)2.86589378
12Birth length less than 3rd percentile (HP:0003561)2.80956668
13Progressive macrocephaly (HP:0004481)2.76964928
14Nephronophthisis (HP:0000090)2.75533013
15True hermaphroditism (HP:0010459)2.72573824
16Abnormality of the corticospinal tract (HP:0002492)2.69450952
17Lipid accumulation in hepatocytes (HP:0006561)2.67776875
18Mitochondrial inheritance (HP:0001427)2.66926482
19Increased CSF lactate (HP:0002490)2.63952013
20Abnormal mitochondria in muscle tissue (HP:0008316)2.57804855
21Acute encephalopathy (HP:0006846)2.55012359
22Abnormality of alanine metabolism (HP:0010916)2.54393753
23Hyperalaninemia (HP:0003348)2.54393753
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54393753
25Focal seizures (HP:0007359)2.53065166
26Abnormality of the renal medulla (HP:0100957)2.51160533
27Abnormality of the renal cortex (HP:0011035)2.50280846
28Methylmalonic acidemia (HP:0002912)2.48707384
29Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.48670171
30Degeneration of the lateral corticospinal tracts (HP:0002314)2.48670171
31Hepatic necrosis (HP:0002605)2.45741641
32Febrile seizures (HP:0002373)2.44851234
33Epileptic encephalopathy (HP:0200134)2.42463383
34Neoplasm of the adrenal cortex (HP:0100641)2.41860170
35Hepatocellular necrosis (HP:0001404)2.37657404
36Intestinal atresia (HP:0011100)2.37369246
37Abnormal lung lobation (HP:0002101)2.32340385
38Myokymia (HP:0002411)2.28706039
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.26282688
40Progressive cerebellar ataxia (HP:0002073)2.25705314
41Gait imbalance (HP:0002141)2.25056516
42Supernumerary spleens (HP:0009799)2.21590349
43Chromsome breakage (HP:0040012)2.16144942
44Visual hallucinations (HP:0002367)2.15715267
45Facial hemangioma (HP:0000329)2.11921753
46Shawl scrotum (HP:0000049)2.10683980
47Abnormal hair whorl (HP:0010721)2.10515613
48Stomach cancer (HP:0012126)2.10330125
49Cerebral hypomyelination (HP:0006808)2.10281804
50Medulloblastoma (HP:0002885)2.08417391
51Abnormality of the anterior horn cell (HP:0006802)2.06853555
52Degeneration of anterior horn cells (HP:0002398)2.06853555
53Broad-based gait (HP:0002136)2.06300494
54Papillary thyroid carcinoma (HP:0002895)2.05846279
55Myelodysplasia (HP:0002863)2.04679139
56Astrocytoma (HP:0009592)2.04608433
57Abnormality of the astrocytes (HP:0100707)2.04608433
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03971999
59Congenital stationary night blindness (HP:0007642)2.03545738
60Sloping forehead (HP:0000340)2.03234819
61Absent radius (HP:0003974)2.02933686
62Dandy-Walker malformation (HP:0001305)2.02750956
63Ependymoma (HP:0002888)2.02533869
64Aplasia/Hypoplasia of the sternum (HP:0006714)2.00987294
65Hypothermia (HP:0002045)1.99918346
66Absent forearm bone (HP:0003953)1.98503506
67Aplasia involving forearm bones (HP:0009822)1.98503506
68Nephroblastoma (Wilms tumor) (HP:0002667)1.95866683
69Cerebral edema (HP:0002181)1.95078612
70Gastroesophageal reflux (HP:0002020)1.94759444
71Congenital primary aphakia (HP:0007707)1.94202444
72Genital tract atresia (HP:0001827)1.92694217
73Patellar aplasia (HP:0006443)1.92223828
74Increased serum lactate (HP:0002151)1.91755918
75Small hand (HP:0200055)1.91082215
76Medial flaring of the eyebrow (HP:0010747)1.90834541
77Aplasia/Hypoplasia of the patella (HP:0006498)1.90455855
78Neoplasm of the oral cavity (HP:0100649)1.89977458
79Absence seizures (HP:0002121)1.89893575
80Hyperventilation (HP:0002883)1.89757317
81Renal Fanconi syndrome (HP:0001994)1.87817121
82Abnormality of the preputium (HP:0100587)1.87709699
83Renal cortical cysts (HP:0000803)1.87008245
84Breast hypoplasia (HP:0003187)1.86960922
85Drooling (HP:0002307)1.86659767
86Excessive salivation (HP:0003781)1.86659767
87Fibular aplasia (HP:0002990)1.86209102
88Dialeptic seizures (HP:0011146)1.86063617
89Termporal pattern (HP:0011008)1.85115909
90Insidious onset (HP:0003587)1.85115909
91Vaginal atresia (HP:0000148)1.83434451
92Aplasia/Hypoplasia of the tongue (HP:0010295)1.83206990
93Embryonal renal neoplasm (HP:0011794)1.83044397
94Reticulocytopenia (HP:0001896)1.81815945
95Anencephaly (HP:0002323)1.81808078
96Amyotrophic lateral sclerosis (HP:0007354)1.81259158
97Abnormality of the lower motor neuron (HP:0002366)1.80334741
98Abnormal biliary tract physiology (HP:0012439)1.80026520
99Bile duct proliferation (HP:0001408)1.80026520
100Rhabdomyosarcoma (HP:0002859)1.79918329
101Chronic hepatic failure (HP:0100626)1.79679220
102Shoulder girdle muscle weakness (HP:0003547)1.79242228
103Mutism (HP:0002300)1.79105084
104Small intestinal stenosis (HP:0012848)1.78388566
105Duodenal stenosis (HP:0100867)1.78388566
106Volvulus (HP:0002580)1.78124814
107Absent speech (HP:0001344)1.76863773
108Gaze-evoked nystagmus (HP:0000640)1.75633015
109Abnormality of the metopic suture (HP:0005556)1.75448819
110Aqueductal stenosis (HP:0002410)1.75292822
111Exertional dyspnea (HP:0002875)1.75227688
112Methylmalonic aciduria (HP:0012120)1.74863621
113Fair hair (HP:0002286)1.73962053
114Nephrogenic diabetes insipidus (HP:0009806)1.72992803
115Abnormality of DNA repair (HP:0003254)1.72947918
116Lissencephaly (HP:0001339)1.71028957
117Type I transferrin isoform profile (HP:0003642)1.70037335
118Spastic gait (HP:0002064)1.69315114
119Hypomagnesemia (HP:0002917)1.68615581
120Fetal akinesia sequence (HP:0001989)1.68597351
121Poor coordination (HP:0002370)1.68475115
122Lactic acidosis (HP:0003128)1.68347206
123Pendular nystagmus (HP:0012043)1.67527986
124Abnormality of cochlea (HP:0000375)1.67258256
125Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.66214871
126Abnormality of the duodenum (HP:0002246)1.66204881
127Morphological abnormality of the inner ear (HP:0011390)1.65610592
128Abnormality of methionine metabolism (HP:0010901)1.64538299
129Neoplasm of the adrenal gland (HP:0100631)1.64322297
130Urinary bladder sphincter dysfunction (HP:0002839)1.64101636
131Optic disc pallor (HP:0000543)1.64001289
132Adrenal hypoplasia (HP:0000835)1.63848965
133Abnormality of chromosome segregation (HP:0002916)1.63721113
134Hypoplasia of the pons (HP:0012110)1.63117656
135Prominent metopic ridge (HP:0005487)1.62851972
136Stenosis of the external auditory canal (HP:0000402)1.62474122
137Abnormality of the pons (HP:0007361)1.62213417
138Thin upper lip vermilion (HP:0000219)1.61708100
139Specific learning disability (HP:0001328)1.60986469
140Oligodactyly (hands) (HP:0001180)1.60911350
141Glioma (HP:0009733)1.60220484
142Abnormality of the septum pellucidum (HP:0007375)1.59315154
143Generalized tonic-clonic seizures (HP:0002069)1.58753940
144Absent septum pellucidum (HP:0001331)1.56708754
145Amblyopia (HP:0000646)1.56315116
146Abnormality of abdominal situs (HP:0011620)1.56231376
147Abdominal situs inversus (HP:0003363)1.56231376
148Agnosia (HP:0010524)1.51930970
149Truncal ataxia (HP:0002078)1.50912994
150Meckel diverticulum (HP:0002245)1.50586235
151Bifid tongue (HP:0010297)1.49780903
152Impaired vibration sensation in the lower limbs (HP:0002166)1.48589192
153Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.48281640
154Short tibia (HP:0005736)1.47566289
155Aplasia/Hypoplasia of the tibia (HP:0005772)1.47236422
156Abnormality of the ileum (HP:0001549)1.46622542
157Broad foot (HP:0001769)1.46311133
158Micropenis (HP:0000054)1.46310425
159Limb dystonia (HP:0002451)1.45667651
160Abnormality of chromosome stability (HP:0003220)1.45363430
161Cerebral inclusion bodies (HP:0100314)1.45114671
162Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.44834498
163Ectopic kidney (HP:0000086)1.44810187
164Septo-optic dysplasia (HP:0100842)1.44776265
165Dysmetria (HP:0001310)1.43360612
166Breast aplasia (HP:0100783)1.43255525
167Action tremor (HP:0002345)1.42734742
168CNS hypomyelination (HP:0003429)1.42547768
169Morphological abnormality of the pyramidal tract (HP:0002062)1.42076731
170Supranuclear gaze palsy (HP:0000605)1.42072539
171Aplasia/hypoplasia of the humerus (HP:0006507)1.41343599
172Broad alveolar ridges (HP:0000187)1.41224309

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K43.18425383
2PNCK3.15142696
3CDC72.94716234
4FRK2.77686160
5MARK12.74097273
6NUAK12.59087219
7CASK2.57981571
8NTRK32.57220019
9MAP3K92.48241799
10EIF2AK32.29523506
11EPHA42.23250449
12MAP2K72.21098820
13ZAK2.15489979
14TRIM282.14771339
15MST42.09683722
16PLK22.07784679
17LATS22.01612304
18STK391.95987626
19AKT31.94805346
20MAP4K21.86171602
21MINK11.80539851
22MAPK131.80458752
23PINK11.77321977
24BMPR1B1.77320294
25VRK21.76988204
26WNK41.71045438
27NTRK21.65760973
28PLK31.64734175
29MARK31.63659352
30ERBB31.59264174
31MAP3K61.52197619
32SRPK11.50207531
33TTK1.45370773
34EIF2AK11.44132235
35BCR1.42229698
36MUSK1.38330623
37BRSK21.37959467
38PAK61.37335622
39TAOK31.33677906
40BRAF1.29918525
41BMPR21.29497378
42DYRK21.28513148
43GRK51.27944142
44SIK31.26559269
45OBSCN1.25980637
46PRPF4B1.24136876
47PRKD31.22387533
48TSSK61.22190262
49CDK121.20270584
50KSR11.17925340
51STK38L1.17454346
52INSRR1.16904641
53CHEK21.16342596
54VRK11.15642321
55MAP3K121.12460085
56PLK11.12349455
57MAP2K41.12081858
58MKNK11.10822041
59KSR21.09676224
60WEE11.08201952
61CCNB11.05994302
62BRD41.05908449
63PAK31.05823297
64STK31.05670552
65TAF11.03205815
66NEK21.00503342
67FGR1.00062418
68NTRK10.99856599
69MKNK20.97405636
70EIF2AK20.95970503
71TRPM70.95727845
72CDK190.90893032
73BUB10.90680305
74CDK50.87901558
75MOS0.85999867
76CHEK10.85674471
77CSNK1G20.85483759
78TYRO30.84638798
79CSNK1G30.83199055
80DYRK1A0.83012859
81DAPK10.82825968
82PBK0.82767495
83CDK140.81748728
84NLK0.81734933
85OXSR10.81542885
86TLK10.80815563
87CDK180.80651381
88STK160.80510385
89PLK40.80349059
90ARAF0.78533558
91CDK150.77867979
92FGFR20.77034920
93DYRK30.76153747
94SGK4940.75462758
95SGK2230.75462758
96TNIK0.74023589
97CAMK2A0.72779219
98UHMK10.72609152
99RPS6KA40.72537251
100RAF10.71640609
101GRK10.71068540
102CSNK1E0.69844237
103PIK3CG0.69312345
104ATM0.68502601
105CDK11A0.67989417
106CDK10.66703494
107NEK10.66370696
108PDK20.65823343
109AURKA0.65712461
110ATR0.64455449
111CDK20.64255738
112PRKCG0.63169049
113CSNK1A1L0.62883808
114CDK80.62756469
115TEC0.61293783
116MAPK100.60309658
117SCYL20.59729009
118PASK0.58156370
119NEK60.57965951
120MELK0.57891818
121NME10.57555095
122AURKB0.56740273
123RIPK40.56654504
124ADRBK20.55997885
125CAMK10.55805918
126ROCK20.55619185
127ERBB40.55576748
128LATS10.55543691
129PRKCE0.55323281
130CSNK1G10.54151362
131SGK20.53125783
132WNK30.51068518
133TXK0.49922821
134WNK10.49871223
135CSNK1D0.49653308
136ALK0.49336938
137FGFR10.48433035
138GSK3B0.48394691
139CLK10.48109793
140FLT30.47516250
141CAMK40.45446421
142SIK20.44204751
143BRSK10.44164647
144PTK2B0.43797806
145CAMK2B0.43685142
146PRKDC0.43272726
147YES10.42102823
148SGK10.41752991
149STK380.40780309
150TGFBR10.40581009
151FER0.39003034
152CSNK2A20.38657398
153CSNK2A10.31456260
154CDK30.31208014

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.56305913
2Nicotine addiction_Homo sapiens_hsa050332.74697601
3Parkinsons disease_Homo sapiens_hsa050122.74110965
4Propanoate metabolism_Homo sapiens_hsa006402.31924940
5Synaptic vesicle cycle_Homo sapiens_hsa047212.07876342
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98803015
7Long-term potentiation_Homo sapiens_hsa047201.92591061
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.92153242
9Ribosome_Homo sapiens_hsa030101.91865517
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.90076215
11One carbon pool by folate_Homo sapiens_hsa006701.89446894
12Oocyte meiosis_Homo sapiens_hsa041141.84176889
13Alzheimers disease_Homo sapiens_hsa050101.77817939
14RNA polymerase_Homo sapiens_hsa030201.74260764
15Basal transcription factors_Homo sapiens_hsa030221.72724779
16Glutamatergic synapse_Homo sapiens_hsa047241.70691725
17Mismatch repair_Homo sapiens_hsa034301.70394793
18Cell cycle_Homo sapiens_hsa041101.70360943
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66827139
20RNA transport_Homo sapiens_hsa030131.65359212
21Circadian entrainment_Homo sapiens_hsa047131.60083710
22Long-term depression_Homo sapiens_hsa047301.56260906
23GABAergic synapse_Homo sapiens_hsa047271.56146277
24Morphine addiction_Homo sapiens_hsa050321.56029235
25Dopaminergic synapse_Homo sapiens_hsa047281.54096174
26Serotonergic synapse_Homo sapiens_hsa047261.50185337
27Amphetamine addiction_Homo sapiens_hsa050311.50030655
28Non-homologous end-joining_Homo sapiens_hsa034501.48634725
29Olfactory transduction_Homo sapiens_hsa047401.47512706
30Regulation of autophagy_Homo sapiens_hsa041401.46121625
31mRNA surveillance pathway_Homo sapiens_hsa030151.45903713
32Pyrimidine metabolism_Homo sapiens_hsa002401.44634166
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43022079
34DNA replication_Homo sapiens_hsa030301.40069980
35Fanconi anemia pathway_Homo sapiens_hsa034601.39339744
36Spliceosome_Homo sapiens_hsa030401.37901427
37Homologous recombination_Homo sapiens_hsa034401.35071885
38RNA degradation_Homo sapiens_hsa030181.33161777
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33064392
40Taste transduction_Homo sapiens_hsa047421.32832937
41Butanoate metabolism_Homo sapiens_hsa006501.28857514
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28564852
43Selenocompound metabolism_Homo sapiens_hsa004501.26892393
44Phototransduction_Homo sapiens_hsa047441.26053299
45Nucleotide excision repair_Homo sapiens_hsa034201.24634553
46Collecting duct acid secretion_Homo sapiens_hsa049661.18973239
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18729171
48Cholinergic synapse_Homo sapiens_hsa047251.14691124
49Axon guidance_Homo sapiens_hsa043601.12586919
50GnRH signaling pathway_Homo sapiens_hsa049121.08731920
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07672571
52Salivary secretion_Homo sapiens_hsa049701.06893185
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03060974
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02376084
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02123406
56Oxytocin signaling pathway_Homo sapiens_hsa049211.02080295
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01149149
58Gap junction_Homo sapiens_hsa045401.00306846
59Insulin secretion_Homo sapiens_hsa049110.97418483
60Glioma_Homo sapiens_hsa052140.96761714
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96585997
62ErbB signaling pathway_Homo sapiens_hsa040120.95257329
63Calcium signaling pathway_Homo sapiens_hsa040200.94866085
64Fatty acid elongation_Homo sapiens_hsa000620.94767923
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94679016
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93823723
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93166170
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92107125
69Colorectal cancer_Homo sapiens_hsa052100.91033577
70Renin secretion_Homo sapiens_hsa049240.89085087
71Melanogenesis_Homo sapiens_hsa049160.87207134
72Estrogen signaling pathway_Homo sapiens_hsa049150.87096858
73Wnt signaling pathway_Homo sapiens_hsa043100.84572282
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84247605
75Base excision repair_Homo sapiens_hsa034100.83961056
76p53 signaling pathway_Homo sapiens_hsa041150.83270876
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.83214361
78Steroid biosynthesis_Homo sapiens_hsa001000.82555688
79Vibrio cholerae infection_Homo sapiens_hsa051100.82517075
80Proteasome_Homo sapiens_hsa030500.82153670
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82071157
82Hippo signaling pathway_Homo sapiens_hsa043900.81171950
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80698073
84Gastric acid secretion_Homo sapiens_hsa049710.79935874
85Cocaine addiction_Homo sapiens_hsa050300.78535898
86Huntingtons disease_Homo sapiens_hsa050160.78125918
87Nitrogen metabolism_Homo sapiens_hsa009100.78019272
88Alcoholism_Homo sapiens_hsa050340.77368535
89cAMP signaling pathway_Homo sapiens_hsa040240.72351663
90Peroxisome_Homo sapiens_hsa041460.72262054
91Renal cell carcinoma_Homo sapiens_hsa052110.71599814
92Hedgehog signaling pathway_Homo sapiens_hsa043400.70952335
93Melanoma_Homo sapiens_hsa052180.69135947
94Ras signaling pathway_Homo sapiens_hsa040140.68747249
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65774479
96Choline metabolism in cancer_Homo sapiens_hsa052310.63264867
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62530725
98Dorso-ventral axis formation_Homo sapiens_hsa043200.62380660
99Primary immunodeficiency_Homo sapiens_hsa053400.62081820
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61852172
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.61437315
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61333882
103MAPK signaling pathway_Homo sapiens_hsa040100.61072976
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60969678
105MicroRNAs in cancer_Homo sapiens_hsa052060.60778476
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.60492299
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60132754
108TGF-beta signaling pathway_Homo sapiens_hsa043500.59647115
109Tight junction_Homo sapiens_hsa045300.58338554
110Purine metabolism_Homo sapiens_hsa002300.58068954
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56948874
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56789347
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.56617544
114Ovarian steroidogenesis_Homo sapiens_hsa049130.55646615
115Endometrial cancer_Homo sapiens_hsa052130.55018281
116Cardiac muscle contraction_Homo sapiens_hsa042600.54937772
117Metabolic pathways_Homo sapiens_hsa011000.54930764
118mTOR signaling pathway_Homo sapiens_hsa041500.54122434
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53726290
120Ether lipid metabolism_Homo sapiens_hsa005650.52117388
121Basal cell carcinoma_Homo sapiens_hsa052170.51592770
122Oxidative phosphorylation_Homo sapiens_hsa001900.51427431
123Pyruvate metabolism_Homo sapiens_hsa006200.51280027
124Rap1 signaling pathway_Homo sapiens_hsa040150.51059187
125Non-small cell lung cancer_Homo sapiens_hsa052230.50983102
126Circadian rhythm_Homo sapiens_hsa047100.50369378
127Epstein-Barr virus infection_Homo sapiens_hsa051690.49234566
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48183567
129Tryptophan metabolism_Homo sapiens_hsa003800.46570899
130Type I diabetes mellitus_Homo sapiens_hsa049400.46051845
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45162943
132Linoleic acid metabolism_Homo sapiens_hsa005910.40692959
133Fatty acid metabolism_Homo sapiens_hsa012120.37730835
134Folate biosynthesis_Homo sapiens_hsa007900.36097781
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30453409
136Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30120066
137beta-Alanine metabolism_Homo sapiens_hsa004100.25903477
138Lysine degradation_Homo sapiens_hsa003100.21853663
139Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19662470
140Maturity onset diabetes of the young_Homo sapiens_hsa049500.19564184
141Fatty acid biosynthesis_Homo sapiens_hsa000610.17910793
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17627921
143Asthma_Homo sapiens_hsa053100.16047450
144NOD-like receptor signaling pathway_Homo sapiens_hsa046210.11264826
145Glutathione metabolism_Homo sapiens_hsa004800.09982017
146Legionellosis_Homo sapiens_hsa051340.09175506
147Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08399733

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