PHF21A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.59818839
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.19416745
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.19416745
4modulation by symbiont of host immune response (GO:0052553)5.19416745
5positive regulation by symbiont of host defense response (GO:0052509)5.19416745
6modulation by symbiont of host defense response (GO:0052031)5.19416745
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.19416745
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.79566478
9regulation of B cell receptor signaling pathway (GO:0050855)4.44476990
10macrophage activation involved in immune response (GO:0002281)4.33523501
11detection of molecule of bacterial origin (GO:0032490)4.23475778
12regulation of gamma-delta T cell activation (GO:0046643)4.20496977
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.20421167
14cellular extravasation (GO:0045123)4.13979694
15antigen processing and presentation of endogenous antigen (GO:0019883)4.04898170
16detection of other organism (GO:0098543)4.00389737
17leukocyte aggregation (GO:0070486)3.90209937
18negative regulation of lymphocyte mediated immunity (GO:0002707)3.88883528
19regulation of gamma-delta T cell differentiation (GO:0045586)3.86698844
20response to interleukin-15 (GO:0070672)3.84090158
21positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.79911907
22detection of external biotic stimulus (GO:0098581)3.75062571
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.74054769
24activated T cell proliferation (GO:0050798)3.73265500
25microglial cell activation (GO:0001774)3.72057741
26detection of bacterium (GO:0016045)3.72003072
27negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.71422575
28leukocyte migration involved in inflammatory response (GO:0002523)3.67923530
29response to peptidoglycan (GO:0032494)3.65982430
30response to muramyl dipeptide (GO:0032495)3.64882962
31neutrophil activation involved in immune response (GO:0002283)3.61814421
32histone H3-K4 trimethylation (GO:0080182)3.59374189
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.58843349
34negative regulation of erythrocyte differentiation (GO:0045647)3.57885661
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.42084689
36response to host immune response (GO:0052572)3.42084689
37cytoplasmic mRNA processing body assembly (GO:0033962)3.41981370
38regulation of interferon-beta biosynthetic process (GO:0045357)3.39857630
39negative regulation of leukocyte mediated immunity (GO:0002704)3.39096271
40histone H3-K36 demethylation (GO:0070544)3.36671929
41neutrophil activation (GO:0042119)3.36274715
42neutrophil mediated immunity (GO:0002446)3.36039620
43detection of biotic stimulus (GO:0009595)3.35339446
44negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.34837847
45negative regulation of cell killing (GO:0031342)3.34837847
46B cell receptor signaling pathway (GO:0050853)3.34800493
47cellular response to interleukin-15 (GO:0071350)3.29970615
48response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.25422293
49response to host (GO:0075136)3.25422293
50response to host defenses (GO:0052200)3.25422293
51negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.24463428
52negative regulation of translation, ncRNA-mediated (GO:0040033)3.24463428
53regulation of translation, ncRNA-mediated (GO:0045974)3.24463428
54positive regulation of histone deacetylation (GO:0031065)3.24339846
55macrophage activation (GO:0042116)3.24164704
56histone H3-K9 demethylation (GO:0033169)3.22443298
57germinal center formation (GO:0002467)3.18350530
58negative regulation of T cell mediated immunity (GO:0002710)3.18040008
59negative regulation of interleukin-12 production (GO:0032695)3.11643451
60mitotic sister chromatid cohesion (GO:0007064)3.09896543
61negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.07680403
62positive regulation of hormone biosynthetic process (GO:0046886)3.07667480
63regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.02839662
64positive T cell selection (GO:0043368)2.99994389
65insulin-like growth factor receptor signaling pathway (GO:0048009)2.98692229
66histone H3-K4 methylation (GO:0051568)2.97309401
67positive regulation of granulocyte differentiation (GO:0030854)2.95528053
68myeloid leukocyte mediated immunity (GO:0002444)2.94742974
69granulocyte activation (GO:0036230)2.93166149
70peptidyl-lysine dimethylation (GO:0018027)2.88466887
71regulation of B cell differentiation (GO:0045577)2.87493577
72negative regulation of B cell mediated immunity (GO:0002713)2.87100334
73negative regulation of immunoglobulin mediated immune response (GO:0002890)2.87100334
74proximal/distal pattern formation (GO:0009954)2.85634322
75respiratory burst (GO:0045730)2.84290116
76pre-miRNA processing (GO:0031054)2.81986601
77peptidyl-lysine trimethylation (GO:0018023)2.80582402
78myeloid cell activation involved in immune response (GO:0002275)2.80136745
79regulation of mast cell degranulation (GO:0043304)2.79819753
80histone H3-K9 methylation (GO:0051567)2.79249545
81negative regulation of type 2 immune response (GO:0002829)2.78935051
82regulation of myeloid leukocyte mediated immunity (GO:0002886)2.76271899
83positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.75927203
84negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.73497943
85negative regulation of T-helper cell differentiation (GO:0045623)2.73434885
86negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.73434885
87positive regulation of cellular amide metabolic process (GO:0034250)2.72668119
88histone lysine demethylation (GO:0070076)2.71110644
89regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.70538879
90positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.70489179
91regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.69218174
92tolerance induction (GO:0002507)2.68439516
93planar cell polarity pathway involved in neural tube closure (GO:0090179)2.68207540
94histone H3-K9 modification (GO:0061647)2.68084800
95antigen processing and presentation via MHC class Ib (GO:0002475)2.63831292
96regulation of leukocyte degranulation (GO:0043300)2.63673820
97production of molecular mediator involved in inflammatory response (GO:0002532)2.63264008
98histone demethylation (GO:0016577)2.61543636
99glucocorticoid receptor signaling pathway (GO:0042921)2.61477257
100regulation of tolerance induction (GO:0002643)2.61422074
101regulation of mast cell activation involved in immune response (GO:0033006)2.60739202
102response to type I interferon (GO:0034340)2.60208137
103histone lysine methylation (GO:0034968)2.59994747
104cellular response to type I interferon (GO:0071357)2.59727930
105type I interferon signaling pathway (GO:0060337)2.59727930
106positive regulation of Rap GTPase activity (GO:0032854)2.59130196
107positive regulation of B cell differentiation (GO:0045579)2.58414062
108NLS-bearing protein import into nucleus (GO:0006607)2.56314233
109regulation of T-helper 2 cell differentiation (GO:0045628)2.55568572
110lateral sprouting from an epithelium (GO:0060601)2.55475385
111embryonic camera-type eye morphogenesis (GO:0048596)2.54349423
112stress granule assembly (GO:0034063)2.54329229
113regulation of amyloid precursor protein catabolic process (GO:1902991)2.53414377
114positive regulation of mast cell activation (GO:0033005)2.53247681
115negative regulation of toll-like receptor signaling pathway (GO:0034122)2.51560319
116phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.51305865
117regulation of macrophage cytokine production (GO:0010935)2.50615709
118embryonic retina morphogenesis in camera-type eye (GO:0060059)2.49849098
119positive regulation of gene expression, epigenetic (GO:0045815)2.49513067
120head development (GO:0060322)2.48140052
121histone H4-K16 acetylation (GO:0043984)2.44494514
122peptidyl-lysine methylation (GO:0018022)2.43653341
123negative regulation of histone methylation (GO:0031061)2.43448217
124regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.42079028
125heart morphogenesis (GO:0003007)2.41366009
126glial cell proliferation (GO:0014009)2.38500631
127negative thymic T cell selection (GO:0045060)2.37943793
128growth hormone receptor signaling pathway (GO:0060396)2.35823829
129negative T cell selection (GO:0043383)2.33629364
130regulation of establishment of planar polarity (GO:0090175)2.33590291
131protein demethylation (GO:0006482)2.33555506
132protein dealkylation (GO:0008214)2.33555506
133regulation of histone deacetylation (GO:0031063)2.31727347
134Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.31373649
135negative regulation of catenin import into nucleus (GO:0035414)2.30469793
136hippo signaling (GO:0035329)2.28207144
137positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.26692480
138regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.26692480
139corticosteroid receptor signaling pathway (GO:0031958)2.25447388
140regulation of protein deacetylation (GO:0090311)2.25324595
141dorsal/ventral axis specification (GO:0009950)2.24206703
142regulation of T cell tolerance induction (GO:0002664)2.24181463
143epithelial cell fate commitment (GO:0072148)2.23744243
144establishment of nucleus localization (GO:0040023)2.23698679
145positive regulation of protein deacetylation (GO:0090312)2.22606508
146cellular response to growth hormone stimulus (GO:0071378)2.22216106
147dendrite morphogenesis (GO:0048813)2.18580859
148genitalia morphogenesis (GO:0035112)2.17630118
149positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.17505491
150regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.17505491
151interkinetic nuclear migration (GO:0022027)2.16542919
152nucleosome disassembly (GO:0006337)2.15188743
153protein-DNA complex disassembly (GO:0032986)2.15188743
154thymic T cell selection (GO:0045061)2.15064814
155axis elongation (GO:0003401)2.13623995
156radial glial cell differentiation (GO:0060019)2.12536980
157negative regulation of vascular permeability (GO:0043116)2.11833062
158regulation of ARF protein signal transduction (GO:0032012)2.10539013
159glandular epithelial cell development (GO:0002068)2.09843437
160body morphogenesis (GO:0010171)2.09011927
161mRNA splice site selection (GO:0006376)2.08781215
162gastrulation with mouth forming second (GO:0001702)2.08409880
163positive regulation of RNA splicing (GO:0033120)2.07731201
164retrograde transport, vesicle recycling within Golgi (GO:0000301)2.07603287
165mRNA stabilization (GO:0048255)2.07495679
166RNA stabilization (GO:0043489)2.07495679
167tube closure (GO:0060606)2.03325139
168regulation of protein polyubiquitination (GO:1902914)2.03202306
169embryonic body morphogenesis (GO:0010172)2.02979060
170neural tube closure (GO:0001843)2.02737184
171paraxial mesoderm development (GO:0048339)2.02243474
172histone methylation (GO:0016571)2.01540002
173type B pancreatic cell development (GO:0003323)2.01444877
174nucleus localization (GO:0051647)2.01376368
175positive thymic T cell selection (GO:0045059)2.00784759
176non-canonical Wnt signaling pathway (GO:0035567)1.99741902
177positive regulation of tolerance induction (GO:0002645)1.99452736
178convergent extension (GO:0060026)1.98880681
179positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)1.98754934
180T cell selection (GO:0045058)1.98336743
181regulation of non-canonical Wnt signaling pathway (GO:2000050)1.96676532
182embryonic eye morphogenesis (GO:0048048)1.95882577
183eye morphogenesis (GO:0048592)1.95066244
184regulation of NFAT protein import into nucleus (GO:0051532)1.95035125
185face development (GO:0060324)1.95013101
186regulation of RNA export from nucleus (GO:0046831)1.94850760

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.57266603
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.93872045
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.88819075
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.75320298
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72108863
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.69609049
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.66896531
8VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.50068690
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48077640
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.47286313
11EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.38739232
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.38146678
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.37004427
14DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.23891022
15EZH2_22144423_ChIP-Seq_EOC_Human2.21429981
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.19072588
17WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.17523747
18KDM2B_26808549_Chip-Seq_DND41_Human2.15315512
19MYC_22102868_ChIP-Seq_BL_Human2.12924375
20TCF7_22412390_ChIP-Seq_EML_Mouse2.12395387
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.12357873
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.08748277
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04986211
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04377628
25ZFP281_27345836_Chip-Seq_ESCs_Mouse2.00557933
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96157088
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.92037206
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91823262
29NFIB_24661679_ChIP-Seq_LUNG_Mouse1.90650835
30TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.86954631
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86593495
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86434341
33KDM2B_26808549_Chip-Seq_JURKAT_Human1.84735650
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.81913640
35MYB_26560356_Chip-Seq_TH2_Human1.80749889
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80666247
37DROSHA_22980978_ChIP-Seq_HELA_Human1.79183768
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74631650
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.72864217
40* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66848021
41* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.64803053
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63208833
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.62537632
44KDM2B_26808549_Chip-Seq_K562_Human1.60798412
45RUNX_20019798_ChIP-Seq_JUKART_Human1.59942041
46ISL1_27105846_Chip-Seq_CPCs_Mouse1.58167622
47SPI1_23547873_ChIP-Seq_NB4_Human1.55413921
48VDR_21846776_ChIP-Seq_THP-1_Human1.55262449
49* MYB_26560356_Chip-Seq_TH1_Human1.51828317
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50043172
51FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.49203997
52* GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48110273
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47993940
54* GATA1_19941827_ChIP-Seq_MEL_Mouse1.47368161
55* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.46460131
56* MAF_26560356_Chip-Seq_TH2_Human1.43483631
57PKCTHETA_26484144_Chip-Seq_BREAST_Human1.43012424
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.42553478
59STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.40493080
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39859207
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.38524538
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37655495
63GATA3_27048872_Chip-Seq_THYMUS_Human1.35434711
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34583955
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.32284077
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31873074
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31126840
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28961548
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.28422876
70SCL_19346495_ChIP-Seq_HPC-7_Human1.28192313
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26325631
72* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26286294
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26043349
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25204527
75JARID2_20064375_ChIP-Seq_MESCs_Mouse1.24833379
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.24109889
77RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24083356
78EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24083356
79* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23903020
80HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23901151
81AHR_22903824_ChIP-Seq_MCF-7_Human1.23820696
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.21292639
83GATA1_19941826_ChIP-Seq_K562_Human1.20969045
84* UTX_26944678_Chip-Seq_JUKART_Human1.20546578
85SPI1_23127762_ChIP-Seq_K562_Human1.19725778
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18166358
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18166358
88VDR_24763502_ChIP-Seq_THP-1_Human1.17724210
89CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16011938
90RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15401421
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14378606
92TP53_16413492_ChIP-PET_HCT116_Human1.13839141
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11743990
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11645864
95STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09766557
96* MAF_26560356_Chip-Seq_TH1_Human1.09407909
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09353916
98RARB_27405468_Chip-Seq_BRAIN_Mouse1.09120971
99* AR_19668381_ChIP-Seq_PC3_Human1.07010351
100VDR_24787735_ChIP-Seq_THP-1_Human1.05972440
101* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05795903
102PU_27001747_Chip-Seq_BMDM_Mouse1.05189067
103JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05089345
104PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04268950
105KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03913818
106KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03913818
107KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03913818
108OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03876398
109NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02726722
110YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02649512
111SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02547871
112IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02212912
113RING1B_27294783_Chip-Seq_ESCs_Mouse1.00884132
114SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00036376
115TCF4_18268006_ChIP-ChIP_LS174T_Human0.99921416
116GATA2_19941826_ChIP-Seq_K562_Human0.99521084
117* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98820005
118GATA1_22025678_ChIP-Seq_K562_Human0.98149350
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97468296
120SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95074343
121TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95069938
122ELK3_25401928_ChIP-Seq_HUVEC_Human0.94777363
123SMAD_19615063_ChIP-ChIP_OVARY_Human0.94662736
124TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94609866
125EZH2_27294783_Chip-Seq_ESCs_Mouse0.91863645
126WT1_19549856_ChIP-ChIP_CCG9911_Human0.91434615
127SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90725816
128MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90340245
129TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89976490
130BRD4_25478319_ChIP-Seq_HGPS_Human0.89305005
131SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88821077
132NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88655326
133* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88123940
134CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88105382
135PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88067307
136SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.88044109
137RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87149066
138EED_16625203_ChIP-ChIP_MESCs_Mouse0.86909039
139GATA2_21666600_ChIP-Seq_HMVEC_Human0.86820832
140GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83507746
141ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.83466758
142RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83065100
143ZNF274_21170338_ChIP-Seq_K562_Hela0.81605024
144ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.81450535
145CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80159986
146* NCOR1_26117541_ChIP-Seq_K562_Human0.79871776
147* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.77437227
148RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.75339971
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.74429660
150CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.73402104
151SMRT_27268052_Chip-Seq_Bcells_Human0.73129723
152GATA3_26560356_Chip-Seq_TH2_Human0.72558156
153AR_21572438_ChIP-Seq_LNCaP_Human0.72194520

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.60646047
2MP0000569_abnormal_digit_pigmentation4.19856338
3MP0003436_decreased_susceptibility_to3.92863454
4MP0001835_abnormal_antigen_presentation2.94083255
5MP0001800_abnormal_humoral_immune2.75954014
6MP0003787_abnormal_imprinting2.71984552
7MP0002419_abnormal_innate_immunity2.70046954
8MP0000685_abnormal_immune_system2.48485352
9MP0008260_abnormal_autophagy2.38823975
10MP0001790_abnormal_immune_system2.38235334
11MP0005387_immune_system_phenotype2.38235334
12MP0005025_abnormal_response_to2.35713787
13MP0005000_abnormal_immune_tolerance2.33027151
14MP0005671_abnormal_response_to2.30999232
15MP0002723_abnormal_immune_serum2.29875360
16MP0002420_abnormal_adaptive_immunity2.27802413
17MP0003172_abnormal_lysosome_physiology2.25810257
18MP0001819_abnormal_immune_cell2.23237970
19MP0005076_abnormal_cell_differentiation2.20553809
20MP0002452_abnormal_antigen_presenting2.09982044
21MP0003183_abnormal_peptide_metabolism2.04520660
22MP0003122_maternal_imprinting2.04358199
23MP0008961_abnormal_basal_metabolism2.03148546
24MP0002405_respiratory_system_inflammati1.99128982
25MP0003828_pulmonary_edema1.90697794
26MP0005248_abnormal_Harderian_gland1.88899834
27MP0005623_abnormal_meninges_morphology1.88836088
28MP0003121_genomic_imprinting1.88471692
29MP0002398_abnormal_bone_marrow1.86637458
30MP0000428_abnormal_craniofacial_morphol1.85225419
31MP0001533_abnormal_skeleton_physiology1.83023762
32MP0003385_abnormal_body_wall1.82322233
33MP0000733_abnormal_muscle_development1.79831714
34MP0003690_abnormal_glial_cell1.78327619
35MP0009278_abnormal_bone_marrow1.78309668
36MP0009785_altered_susceptibility_to1.77466393
37MP0002009_preneoplasia1.75451033
38MP0003300_gastrointestinal_ulcer1.73920885
39MP0000716_abnormal_immune_system1.73062959
40MP0003935_abnormal_craniofacial_develop1.63922701
41MP0003115_abnormal_respiratory_system1.61200355
42MP0003942_abnormal_urinary_system1.54027806
43MP0002132_abnormal_respiratory_system1.53073767
44MP0004883_abnormal_blood_vessel1.52551382
45MP0006082_CNS_inflammation1.51871360
46MP0005503_abnormal_tendon_morphology1.50017275
47MP0002653_abnormal_ependyma_morphology1.49712258
48MP0001851_eye_inflammation1.48332295
49MP0002722_abnormal_immune_system1.47627709
50MP0004808_abnormal_hematopoietic_stem1.45703692
51MP0000689_abnormal_spleen_morphology1.41358790
52MP0003866_abnormal_defecation1.41323763
53MP0005187_abnormal_penis_morphology1.41261647
54MP0001299_abnormal_eye_distance/1.39387340
55MP0002166_altered_tumor_susceptibility1.39338865
56MP0002277_abnormal_respiratory_mucosa1.38619897
57MP0004947_skin_inflammation1.36853201
58MP0003045_fibrosis1.36283076
59MP0004381_abnormal_hair_follicle1.33124007
60MP0005464_abnormal_platelet_physiology1.32424820
61MP0002116_abnormal_craniofacial_bone1.29218386
62MP0000432_abnormal_head_morphology1.29123870
63MP0001545_abnormal_hematopoietic_system1.27639013
64MP0005397_hematopoietic_system_phenotyp1.27639013
65MP0002998_abnormal_bone_remodeling1.26954497
66MP0003937_abnormal_limbs/digits/tail_de1.26728384
67MP0009780_abnormal_chondrocyte_physiolo1.25788596
68MP0002429_abnormal_blood_cell1.25767727
69MP0009250_abnormal_appendicular_skeleto1.23305688
70MP0000049_abnormal_middle_ear1.22404868
71MP0003283_abnormal_digestive_organ1.21392941
72MP0000778_abnormal_nervous_system1.20925933
73MP0004859_abnormal_synaptic_plasticity1.20784105
74MP0001293_anophthalmia1.19422328
75MP0001346_abnormal_lacrimal_gland1.18939945
76MP0002396_abnormal_hematopoietic_system1.17685678
77MP0002932_abnormal_joint_morphology1.17380108
78MP0004130_abnormal_muscle_cell1.17152018
79MP0001845_abnormal_inflammatory_respons1.16720937
80MP0002089_abnormal_postnatal_growth/wei1.16466965
81MP0000537_abnormal_urethra_morphology1.15827613
82MP0010155_abnormal_intestine_physiology1.15794780
83MP0005451_abnormal_body_composition1.15653661
84MP0000534_abnormal_ureter_morphology1.11848014
85MP0002925_abnormal_cardiovascular_devel1.11744927
86MP0009703_decreased_birth_body1.11695466
87MP0001879_abnormal_lymphatic_vessel1.11355565
88MP0003755_abnormal_palate_morphology1.11107637
89MP0000465_gastrointestinal_hemorrhage1.10585590
90MP0003091_abnormal_cell_migration1.10362963
91MP0010352_gastrointestinal_tract_polyps1.09707629
92MP0001270_distended_abdomen1.09443616
93MP0001849_ear_inflammation1.09299604
94MP0009053_abnormal_anal_canal1.08549961
95MP0003567_abnormal_fetal_cardiomyocyte1.08369443
96MP0002148_abnormal_hypersensitivity_rea1.07731155
97MP0008877_abnormal_DNA_methylation1.06704912
98MP0000003_abnormal_adipose_tissue1.06215013
99MP0004197_abnormal_fetal_growth/weight/1.05643978
100MP0010030_abnormal_orbit_morphology1.05424893
101MP0001348_abnormal_lacrimal_gland1.05250956
102MP0002249_abnormal_larynx_morphology1.04705995
103MP0004885_abnormal_endolymph1.04516991
104MP0003119_abnormal_digestive_system1.03871200
105MP0003861_abnormal_nervous_system1.02743040
106MP0002697_abnormal_eye_size1.00287555
107MP0005310_abnormal_salivary_gland1.00168647
108MP0003303_peritoneal_inflammation0.98480040
109MP0003191_abnormal_cellular_cholesterol0.98265720
110MP0002177_abnormal_outer_ear0.98203801
111MP0002877_abnormal_melanocyte_morpholog0.97602318
112MP0003890_abnormal_embryonic-extraembry0.97170296
113MP0002092_abnormal_eye_morphology0.96571652
114MP0002109_abnormal_limb_morphology0.95332554
115MP0003656_abnormal_erythrocyte_physiolo0.94185017
116MP0002084_abnormal_developmental_patter0.94009357
117MP0003705_abnormal_hypodermis_morpholog0.93387728
118MP0004233_abnormal_muscle_weight0.93374333
119MP0002938_white_spotting0.93022655
120MP0005164_abnormal_response_to0.92878232
121MP0001958_emphysema0.92655220
122MP0005390_skeleton_phenotype0.92368930
123MP0006072_abnormal_retinal_apoptosis0.91218721
124MP0000703_abnormal_thymus_morphology0.90882684
125MP0005174_abnormal_tail_pigmentation0.90435416
126MP0002928_abnormal_bile_duct0.89154111
127MP0002006_tumorigenesis0.87562405
128MP0002933_joint_inflammation0.87201124
129MP0001784_abnormal_fluid_regulation0.85493934
130MP0005409_darkened_coat_color0.84014363
131MP0004510_myositis0.83769099
132MP0000462_abnormal_digestive_system0.83179344
133MP0001986_abnormal_taste_sensitivity0.83144960
134MP0005375_adipose_tissue_phenotype0.82869852
135MP0002108_abnormal_muscle_morphology0.82782149
136MP0002085_abnormal_embryonic_tissue0.82765513
137MP0005508_abnormal_skeleton_morphology0.82600315
138MP0003763_abnormal_thymus_physiology0.82384662
139MP0002114_abnormal_axial_skeleton0.82111555
140MP0009672_abnormal_birth_weight0.81346831
141MP0000516_abnormal_urinary_system0.80254488
142MP0005367_renal/urinary_system_phenotyp0.80254488
143MP0000858_altered_metastatic_potential0.79825457
144MP0008469_abnormal_protein_level0.78879963
145MP0002133_abnormal_respiratory_system0.78515748
146MP0005388_respiratory_system_phenotype0.78515748
147MP0006054_spinal_hemorrhage0.78117762
148MP0000566_synostosis0.77989347
149* MP0002081_perinatal_lethality0.77314824
150MP0008438_abnormal_cutaneous_collagen0.76970807
151MP0000767_abnormal_smooth_muscle0.76372065
152MP0003279_aneurysm0.76348583
153MP0003878_abnormal_ear_physiology0.75842257
154MP0005377_hearing/vestibular/ear_phenot0.75842257
155MP0010630_abnormal_cardiac_muscle0.74533614
156MP0001915_intracranial_hemorrhage0.74346224
157MP0000266_abnormal_heart_morphology0.74148877
158MP0003221_abnormal_cardiomyocyte_apopto0.73022543
159MP0000015_abnormal_ear_pigmentation0.72820859
160MP0010368_abnormal_lymphatic_system0.72707020
161MP0002233_abnormal_nose_morphology0.71666701
162MP0009333_abnormal_splenocyte_physiolog0.71604374
163MP0000631_abnormal_neuroendocrine_gland0.70233501
164MP0008569_lethality_at_weaning0.69136883
165MP0009115_abnormal_fat_cell0.65859741
166MP0003329_amyloid_beta_deposits0.63931685
167MP0005666_abnormal_adipose_tissue0.60156606
168MP0000604_amyloidosis0.57110206
169MP0000249_abnormal_blood_vessel0.54630421
170MP0003795_abnormal_bone_structure0.54027999
171MP0009764_decreased_sensitivity_to0.53147054
172MP0003075_altered_response_to0.53049513

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.32536184
2Recurrent bacterial skin infections (HP:0005406)4.52176715
3Myositis (HP:0100614)4.48984329
4Recurrent abscess formation (HP:0002722)4.45330979
5Orchitis (HP:0100796)4.04953114
6Retrobulbar optic neuritis (HP:0100654)3.91310928
7Optic neuritis (HP:0100653)3.91310928
8Recurrent gram-negative bacterial infections (HP:0005420)3.78155058
9Gastrointestinal infarctions (HP:0005244)3.73115352
10Abnormality of the fingertips (HP:0001211)3.64893057
11Spontaneous hematomas (HP:0007420)3.64191028
12Abnormality of macrophages (HP:0004311)3.64059771
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.53331286
14Short 4th metacarpal (HP:0010044)3.53331286
15Peritonitis (HP:0002586)3.52587009
16Stomatitis (HP:0010280)3.52258188
17Recurrent fungal infections (HP:0002841)3.37979030
18Shallow orbits (HP:0000586)3.36044422
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.34894928
20Macroorchidism (HP:0000053)3.30362343
21Hypochromic microcytic anemia (HP:0004840)3.25434287
22Elevated erythrocyte sedimentation rate (HP:0003565)3.24859608
23Increased IgE level (HP:0003212)3.12065292
24Meningitis (HP:0001287)3.09389497
25Volvulus (HP:0002580)3.07412792
26Chronic mucocutaneous candidiasis (HP:0002728)3.06518234
27Recurrent cutaneous fungal infections (HP:0011370)3.06518234
28Recurrent skin infections (HP:0001581)3.06366872
29Mediastinal lymphadenopathy (HP:0100721)3.04816539
30Gingivitis (HP:0000230)3.02811992
31Papilledema (HP:0001085)2.90560416
32Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.80932701
33Encephalitis (HP:0002383)2.78940207
34Prolonged bleeding time (HP:0003010)2.75451429
35Keratoconjunctivitis sicca (HP:0001097)2.73596764
36Trigonocephaly (HP:0000243)2.73538089
37Chronic obstructive pulmonary disease (HP:0006510)2.71810878
38Obstructive lung disease (HP:0006536)2.71810878
39Narrow palate (HP:0000189)2.68707665
40Chest pain (HP:0100749)2.67298906
41Abnormality of the 4th metacarpal (HP:0010012)2.66398101
42Cellulitis (HP:0100658)2.65749810
43Vasculitis (HP:0002633)2.63827299
44Hyperacusis (HP:0010780)2.62757764
45Broad metatarsal (HP:0001783)2.60646570
46Midline defect of the nose (HP:0004122)2.56617683
47Abnormality of the peritoneum (HP:0002585)2.56266317
48Long eyelashes (HP:0000527)2.55006187
49T lymphocytopenia (HP:0005403)2.51148661
50Gingival bleeding (HP:0000225)2.49917019
51Hypochromic anemia (HP:0001931)2.44764906
52Renal duplication (HP:0000075)2.42262315
53Keratoconjunctivitis (HP:0001096)2.40939560
54Leukocytosis (HP:0001974)2.39025661
55Abnormality of the parietal bone (HP:0002696)2.37379856
56Inflammation of the large intestine (HP:0002037)2.32788170
57Episodic fever (HP:0001954)2.32675943
58Cerebral aneurysm (HP:0004944)2.31744002
59Gastrointestinal inflammation (HP:0004386)2.31743505
60Supernumerary ribs (HP:0005815)2.31542037
61Obsessive-compulsive behavior (HP:0000722)2.30538195
62Panhypogammaglobulinemia (HP:0003139)2.29027594
63Hemoptysis (HP:0002105)2.27012294
64Elfin facies (HP:0004428)2.25937070
65Arterial thrombosis (HP:0004420)2.25126301
66Abnormality of T cell number (HP:0011839)2.23430645
67Genetic anticipation (HP:0003743)2.22040378
68Hemiplegia (HP:0002301)2.17360994
69Increased nuchal translucency (HP:0010880)2.16472772
70Metaphyseal cupping (HP:0003021)2.15745689
71Difficulty running (HP:0009046)2.14883708
72Abnormality of the nasal septum (HP:0000419)2.13406400
73Urticaria (HP:0001025)2.12944265
74Colitis (HP:0002583)2.12298733
75Renovascular hypertension (HP:0100817)2.11470870
76Broad thumb (HP:0011304)2.09590108
77Neoplasm of the heart (HP:0100544)2.07438942
78Pulmonary infiltrates (HP:0002113)2.05174636
79Heterotopia (HP:0002282)2.04062377
80Pustule (HP:0200039)2.03183254
81Pulmonary embolism (HP:0002204)2.02431304
82Epistaxis (HP:0000421)2.01499773
83Absent frontal sinuses (HP:0002688)2.00709994
84Abnormality of incisor morphology (HP:0011063)2.00530826
85Syringomyelia (HP:0003396)2.00191181
86Spinal cord lesions (HP:0100561)2.00191181
87Recurrent viral infections (HP:0004429)1.99841474
88Abnormality of the diencephalon (HP:0010662)1.99324999
89Aqueductal stenosis (HP:0002410)1.98943457
90Overriding aorta (HP:0002623)1.97837242
91Supernumerary bones of the axial skeleton (HP:0009144)1.96684658
92Slow saccadic eye movements (HP:0000514)1.96498873
93Abnormality of the endocardium (HP:0004306)1.94881007
94Sepsis (HP:0100806)1.92785809
95Viral hepatitis (HP:0006562)1.92169262
96Anal stenosis (HP:0002025)1.91639435
97Hepatoblastoma (HP:0002884)1.91068584
98Neoplasm of the oral cavity (HP:0100649)1.91063019
99Subacute progressive viral hepatitis (HP:0006572)1.89671219
100Amyloidosis (HP:0011034)1.88239557
101Osteomyelitis (HP:0002754)1.88181627
102Lymphopenia (HP:0001888)1.88155905
103Thick eyebrow (HP:0000574)1.86871530
104Flat cornea (HP:0007720)1.85243170
105Hypoplasia of the maxilla (HP:0000327)1.82517761
106Deep palmar crease (HP:0006191)1.81457319
107Microcytic anemia (HP:0001935)1.80385907
108Abnormality of T cells (HP:0002843)1.80289837
109Aortic aneurysm (HP:0004942)1.79687843
110Hypoplastic labia majora (HP:0000059)1.79161379
111Broad finger (HP:0001500)1.78480250
112Broad phalanges of the hand (HP:0009768)1.78459249
113Lymphangioma (HP:0100764)1.76888480
114Granulocytopenia (HP:0001913)1.76088350
115Abnormality of binocular vision (HP:0011514)1.75897490
116Diplopia (HP:0000651)1.75897490
117Bowel diverticulosis (HP:0005222)1.75810398
118Smooth philtrum (HP:0000319)1.74676729
119Dislocated radial head (HP:0003083)1.74476842
120Truncal obesity (HP:0001956)1.73030417
121Broad phalanx (HP:0006009)1.72076144
122Abnormal hair whorl (HP:0010721)1.71864353
123Abnormality of the radial head (HP:0003995)1.71493413
124Disproportionate tall stature (HP:0001519)1.71369034
125Enlarged penis (HP:0000040)1.70789814
126Asymmetry of the thorax (HP:0001555)1.70671699
127Synophrys (HP:0000664)1.70338206
128Spondylolisthesis (HP:0003302)1.70064316
129Bladder diverticulum (HP:0000015)1.69322206
130Pointed chin (HP:0000307)1.68650790
131Recurrent bronchitis (HP:0002837)1.68565658
132Acne (HP:0001061)1.67857776
133Agammaglobulinemia (HP:0004432)1.67837644
134Alacrima (HP:0000522)1.66948462
135Laryngomalacia (HP:0001601)1.66856093
136Abnormality of the pleura (HP:0002103)1.66840063
137Recurrent sinusitis (HP:0011108)1.66828467
138Abnormality of the columella (HP:0009929)1.66122770
139Broad toe (HP:0001837)1.65641375
140Transitional cell carcinoma of the bladder (HP:0006740)1.64546909
141Chronic otitis media (HP:0000389)1.64218948
142Deviation of the hallux (HP:0010051)1.64213718
143Abnormality of cells of the lymphoid lineage (HP:0012140)1.63746607
144Broad long bones (HP:0005622)1.63446771
145Urethral obstruction (HP:0000796)1.63123348
146Depressed nasal tip (HP:0000437)1.62847152
147Vertebral arch anomaly (HP:0008438)1.62696108
148Abnormality of the astrocytes (HP:0100707)1.62517411
149Astrocytoma (HP:0009592)1.62517411
150Broad hallux (HP:0010055)1.62286236
151Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.61231340
152Leiomyosarcoma (HP:0100243)1.61158426
153Uterine leiomyosarcoma (HP:0002891)1.61158426
154Vitreoretinal degeneration (HP:0000655)1.61059698
155Arnold-Chiari malformation (HP:0002308)1.60669667
156Obstructive sleep apnea (HP:0002870)1.60439445
157Bell-shaped thorax (HP:0001591)1.60106019
158Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.59268425
159Abnormality of the labia majora (HP:0012881)1.59122213
160Mitral valve prolapse (HP:0001634)1.58433771
161Hallux valgus (HP:0001822)1.56906192
162Papillary thyroid carcinoma (HP:0002895)1.56879925
163Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.56339565
164Peripheral hypomyelination (HP:0007182)1.55767095
165Polycythemia (HP:0001901)1.55016371
166Vertigo (HP:0002321)1.54793423
167Segmental peripheral demyelination/remyelination (HP:0003481)1.54296530
168Bladder neoplasm (HP:0009725)1.53891931
169Bladder carcinoma (HP:0002862)1.53891931
170Broad palm (HP:0001169)1.53193706
171Cutaneous finger syndactyly (HP:0010554)1.52818720
172Sacral dimple (HP:0000960)1.52152272
173Increased number of teeth (HP:0011069)1.51769184
174Anorexia (HP:0002039)1.50560148
175Deep philtrum (HP:0002002)1.50320157
176Onion bulb formation (HP:0003383)1.50253104
177Hypoplastic ischia (HP:0003175)1.50013816
178Dental malocclusion (HP:0000689)1.49531290
179Vesicoureteral reflux (HP:0000076)1.49499369
180Ureteral obstruction (HP:0006000)1.48538925
181Acute lymphatic leukemia (HP:0006721)1.48398346
182Anteriorly placed anus (HP:0001545)1.48010000
183Hematochezia (HP:0002573)1.47965901
184Ureteral stenosis (HP:0000071)1.47777800
185Skin tags (HP:0010609)1.47680825
186Decreased lacrimation (HP:0000633)1.47668250
187Turricephaly (HP:0000262)1.47269188

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.63821418
2CDK123.53756878
3CAMK1G2.97316596
4BRD42.55037057
5CAMK1D2.37186824
6IRAK42.27109707
7MAP3K102.26695799
8BLK2.18422110
9FGFR22.10766479
10ERN12.04804366
11MAP2K31.99469079
12SIK21.93500969
13FES1.90492699
14ICK1.83566725
15PDGFRA1.80385690
16PTK61.77763604
17DMPK1.73441038
18FGFR31.73328313
19INSRR1.66829932
20TRIB31.63091767
21YES11.60665834
22PRKD21.58740470
23SIK11.54860659
24KSR21.51176578
25HIPK21.48271980
26LATS11.45895932
27GRK61.44642722
28ZAP701.42626990
29TYRO31.35700116
30EEF2K1.35654497
31PRKD31.34117053
32FGR1.33715528
33WNK11.31518810
34NTRK21.31210573
35MAP3K131.27458336
36PKN21.25225524
37JAK21.23175733
38PDGFRB1.22949147
39CSNK1A1L1.21493996
40CDC42BPA1.20079795
41MTOR1.19823836
42MARK21.19517522
43TXK1.19241735
44SGK31.18913608
45SYK1.18514141
46SIK31.14681773
47NLK1.14140942
48EPHB11.11866085
49FGFR41.11411536
50IKBKE1.09801358
51TAOK11.09261009
52CHUK1.08961436
53PRKCH1.08867593
54MARK31.08665075
55JAK11.08156563
56AKT31.03143496
57MAP3K71.01323769
58MAP3K61.00796382
59DDR20.99488922
60CAMK40.98927099
61RIPK10.98173552
62MAP3K10.97201533
63CDK60.95412703
64FGFR10.94949642
65TGFBR20.94085779
66EPHA30.91992389
67MAPK70.91254202
68CDK90.91080942
69MKNK20.90535011
70SGK20.90185996
71LYN0.89153623
72MAP3K140.87288966
73TNIK0.86412970
74PTK20.86357542
75DYRK1B0.86356346
76RET0.82575710
77ALK0.81896212
78EPHB20.79620316
79MARK10.79388448
80MAP3K30.77564225
81MAP4K10.77219985
82ITK0.75027791
83LRRK20.74908274
84STK380.74409244
85PRKD10.74281299
86HCK0.73339567
87JAK30.72905288
88CAMKK10.71906881
89STK110.71702422
90BMX0.71252288
91CSNK1G10.70589795
92MAP2K40.70335112
93PDK10.70080210
94UHMK10.69935347
95ERBB20.68225470
96KIT0.67576487
97BTK0.67525147
98STK30.67005773
99CLK10.66658981
100PTK2B0.66407802
101TBK10.65992122
102MKNK10.65527334
103CSNK1G20.64472887
104PASK0.62740885
105MAP3K20.62325453
106IRAK20.59295933
107PAK20.58926849
108MAPK120.58624198
109PRKAA20.58394092
110TTN0.58260445
111RAF10.58234403
112CDK190.57648359
113TEC0.57263816
114PKN10.56932710
115SGK10.55785128
116MAPK80.54225905
117TYK20.53872592
118PRPF4B0.53322467
119MAP3K110.53220530
120SGK2230.52819668
121SGK4940.52819668
122MAPK100.52132711
123PIK3CG0.49683763
124IRAK10.49548736
125CSK0.48989072
126MAPK140.47823153
127AKT10.47711297
128NTRK30.47335935
129PRKCZ0.47325969
130CSF1R0.47035897
131CSNK1G30.46993248
132RPS6KC10.46991627
133RPS6KL10.46991627
134TNK20.46908755
135FYN0.46194345
136MAPK10.46109565
137KSR10.46017311
138TAOK30.45968390
139GSK3B0.45717632
140GSK3A0.45404695
141NEK20.43619339
142LCK0.42830003
143CSNK1D0.41805937
144PRKDC0.41288657
145CAMK10.40962876

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.00242569
2Basal cell carcinoma_Homo sapiens_hsa052171.58526976
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58516820
4Chronic myeloid leukemia_Homo sapiens_hsa052201.57889766
5Notch signaling pathway_Homo sapiens_hsa043301.57475243
6Staphylococcus aureus infection_Homo sapiens_hsa051501.52550373
7Tuberculosis_Homo sapiens_hsa051521.47312644
8Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46359789
9Lysine degradation_Homo sapiens_hsa003101.43104514
10Endometrial cancer_Homo sapiens_hsa052131.39649167
11Type II diabetes mellitus_Homo sapiens_hsa049301.39329552
12Thyroid hormone signaling pathway_Homo sapiens_hsa049191.36248687
13B cell receptor signaling pathway_Homo sapiens_hsa046621.34882021
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31460457
15MicroRNAs in cancer_Homo sapiens_hsa052061.30153200
16Neurotrophin signaling pathway_Homo sapiens_hsa047221.26110709
17Malaria_Homo sapiens_hsa051441.26031946
18Dorso-ventral axis formation_Homo sapiens_hsa043201.25756141
19Hedgehog signaling pathway_Homo sapiens_hsa043401.24036179
20Colorectal cancer_Homo sapiens_hsa052101.23631580
21T cell receptor signaling pathway_Homo sapiens_hsa046601.23351547
22Renal cell carcinoma_Homo sapiens_hsa052111.23207931
23Non-small cell lung cancer_Homo sapiens_hsa052231.22274639
24Proteoglycans in cancer_Homo sapiens_hsa052051.22182055
25Axon guidance_Homo sapiens_hsa043601.21996117
26Wnt signaling pathway_Homo sapiens_hsa043101.21416299
27Glioma_Homo sapiens_hsa052141.19941961
28mTOR signaling pathway_Homo sapiens_hsa041501.19446497
29Adherens junction_Homo sapiens_hsa045201.18739889
30Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.17384443
31Prostate cancer_Homo sapiens_hsa052151.15911780
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15063844
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15024548
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13795851
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12678602
36Small cell lung cancer_Homo sapiens_hsa052221.12532976
37Acute myeloid leukemia_Homo sapiens_hsa052211.12292353
38Focal adhesion_Homo sapiens_hsa045101.11616246
39Pancreatic cancer_Homo sapiens_hsa052121.10988984
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09933021
41Influenza A_Homo sapiens_hsa051641.09153187
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08884946
43Estrogen signaling pathway_Homo sapiens_hsa049151.06261856
44Graft-versus-host disease_Homo sapiens_hsa053321.06210018
45Osteoclast differentiation_Homo sapiens_hsa043801.05857512
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05760224
47ErbB signaling pathway_Homo sapiens_hsa040121.05583868
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03050674
49Melanogenesis_Homo sapiens_hsa049161.02885208
50Prolactin signaling pathway_Homo sapiens_hsa049171.01832132
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01028444
52Pathways in cancer_Homo sapiens_hsa052000.98418446
53Hippo signaling pathway_Homo sapiens_hsa043900.97554325
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97484464
55Circadian entrainment_Homo sapiens_hsa047130.96755493
56Platelet activation_Homo sapiens_hsa046110.96727317
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96712251
58Inositol phosphate metabolism_Homo sapiens_hsa005620.95910325
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95871538
60Long-term potentiation_Homo sapiens_hsa047200.95250482
61Chemokine signaling pathway_Homo sapiens_hsa040620.94702715
62Renin secretion_Homo sapiens_hsa049240.93552021
63Rap1 signaling pathway_Homo sapiens_hsa040150.93255291
64mRNA surveillance pathway_Homo sapiens_hsa030150.92714205
65MAPK signaling pathway_Homo sapiens_hsa040100.92383735
66Insulin secretion_Homo sapiens_hsa049110.91610495
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91244654
68Hepatitis C_Homo sapiens_hsa051600.91046365
69Allograft rejection_Homo sapiens_hsa053300.90192845
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.90038822
71Cholinergic synapse_Homo sapiens_hsa047250.89849963
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.89803409
73Insulin resistance_Homo sapiens_hsa049310.89792193
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89316393
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.88918946
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88808611
77Hematopoietic cell lineage_Homo sapiens_hsa046400.87886383
78HTLV-I infection_Homo sapiens_hsa051660.87819449
79VEGF signaling pathway_Homo sapiens_hsa043700.87564157
80Viral myocarditis_Homo sapiens_hsa054160.87138082
81Primary immunodeficiency_Homo sapiens_hsa053400.86820234
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86726457
83cAMP signaling pathway_Homo sapiens_hsa040240.86721545
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86640869
85Toxoplasmosis_Homo sapiens_hsa051450.86098472
86Choline metabolism in cancer_Homo sapiens_hsa052310.85118014
87Autoimmune thyroid disease_Homo sapiens_hsa053200.84986649
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84695200
89Cocaine addiction_Homo sapiens_hsa050300.84630891
90Hepatitis B_Homo sapiens_hsa051610.84135259
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84058440
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83671785
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.83601425
94Herpes simplex infection_Homo sapiens_hsa051680.83541524
95Oxytocin signaling pathway_Homo sapiens_hsa049210.82691486
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82485175
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81744843
98Dilated cardiomyopathy_Homo sapiens_hsa054140.80863010
99Glutamatergic synapse_Homo sapiens_hsa047240.78340773
100FoxO signaling pathway_Homo sapiens_hsa040680.77415710
101Circadian rhythm_Homo sapiens_hsa047100.76774730
102GnRH signaling pathway_Homo sapiens_hsa049120.76763059
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.76518339
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75827681
105Long-term depression_Homo sapiens_hsa047300.75313047
106ECM-receptor interaction_Homo sapiens_hsa045120.75223555
107Measles_Homo sapiens_hsa051620.75221753
108Phagosome_Homo sapiens_hsa041450.74121794
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74114996
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74056177
111Legionellosis_Homo sapiens_hsa051340.73776847
112Insulin signaling pathway_Homo sapiens_hsa049100.73483683
113Amoebiasis_Homo sapiens_hsa051460.72681969
114Dopaminergic synapse_Homo sapiens_hsa047280.71680616
115Endocytosis_Homo sapiens_hsa041440.71619299
116Amphetamine addiction_Homo sapiens_hsa050310.71185146
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70979360
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70908787
119HIF-1 signaling pathway_Homo sapiens_hsa040660.70881881
120Ras signaling pathway_Homo sapiens_hsa040140.70512257
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70509406
122TNF signaling pathway_Homo sapiens_hsa046680.70063362
123African trypanosomiasis_Homo sapiens_hsa051430.69099845
124Morphine addiction_Homo sapiens_hsa050320.68974009
125Gap junction_Homo sapiens_hsa045400.68584520
126TGF-beta signaling pathway_Homo sapiens_hsa043500.68545172
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68451556
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68357775
129Type I diabetes mellitus_Homo sapiens_hsa049400.66403754
130Thyroid cancer_Homo sapiens_hsa052160.64172889
131Antigen processing and presentation_Homo sapiens_hsa046120.63116816
132Apoptosis_Homo sapiens_hsa042100.60487960
133Regulation of autophagy_Homo sapiens_hsa041400.59578877
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.55610949
135Salmonella infection_Homo sapiens_hsa051320.55288405

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