PHF23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)4.39998360
2regulation of gene silencing by RNA (GO:0060966)4.20416429
3regulation of posttranscriptional gene silencing (GO:0060147)4.20416429
4regulation of gene silencing by miRNA (GO:0060964)4.20416429
5viral transcription (GO:0019083)4.20287472
6DNA unwinding involved in DNA replication (GO:0006268)4.19543813
7maturation of SSU-rRNA (GO:0030490)4.18060732
8protein localization to endosome (GO:0036010)4.17818804
9formation of translation preinitiation complex (GO:0001731)4.11330560
10translational termination (GO:0006415)4.09284097
11negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.95799613
12regulation of chromatin binding (GO:0035561)3.95463697
13heterochromatin organization (GO:0070828)3.86396898
14negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.80350107
15mitotic metaphase plate congression (GO:0007080)3.75902301
16translational initiation (GO:0006413)3.74905506
17regulation of early endosome to late endosome transport (GO:2000641)3.74660401
18protein localization to chromosome, centromeric region (GO:0071459)3.74590930
19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.70806598
20ribosomal small subunit biogenesis (GO:0042274)3.70426626
21translational elongation (GO:0006414)3.68120309
22mitotic nuclear envelope disassembly (GO:0007077)3.57399147
23planar cell polarity pathway involved in neural tube closure (GO:0090179)3.55381154
24folic acid-containing compound biosynthetic process (GO:0009396)3.46819940
25regulation of mammary gland epithelial cell proliferation (GO:0033599)3.45159301
26DNA replication-dependent nucleosome organization (GO:0034723)3.43822182
27DNA replication-dependent nucleosome assembly (GO:0006335)3.43822182
28pre-miRNA processing (GO:0031054)3.41741980
29nuclear pore complex assembly (GO:0051292)3.41308669
30nuclear pore organization (GO:0006999)3.40903196
31ribosomal large subunit biogenesis (GO:0042273)3.39593360
32nuclear envelope disassembly (GO:0051081)3.39178972
33membrane disassembly (GO:0030397)3.39178972
34ribosome assembly (GO:0042255)3.36267098
35ribosomal small subunit assembly (GO:0000028)3.36227670
36cellular protein complex localization (GO:0034629)3.34278046
37mitotic chromosome condensation (GO:0007076)3.30201397
38DNA replication initiation (GO:0006270)3.29642558
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.28998189
40DNA replication checkpoint (GO:0000076)3.27091100
41regulation of spindle organization (GO:0090224)3.26195535
42mitotic sister chromatid segregation (GO:0000070)3.20263224
43viral life cycle (GO:0019058)3.20153406
44ribonucleoprotein complex biogenesis (GO:0022613)3.19332861
45cellular protein complex disassembly (GO:0043624)3.18957536
46regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.18016327
47regulation of retinoic acid receptor signaling pathway (GO:0048385)3.11853733
48DNA strand elongation involved in DNA replication (GO:0006271)3.11638837
49positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.11255080
50regulation of translational fidelity (GO:0006450)3.06795904
51SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.05813157
52protein complex disassembly (GO:0043241)3.04952430
53metaphase plate congression (GO:0051310)3.03098021
54ribosome biogenesis (GO:0042254)3.02374311
55negative regulation of histone methylation (GO:0031061)3.00736257
56protein targeting to ER (GO:0045047)2.99190831
57paraxial mesoderm development (GO:0048339)2.98471893
58histone H2A monoubiquitination (GO:0035518)2.98135089
59negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.97493902
60cotranslational protein targeting to membrane (GO:0006613)2.96082699
61DNA strand elongation (GO:0022616)2.96068741
62convergent extension (GO:0060026)2.95613679
63IMP biosynthetic process (GO:0006188)2.94571955
64establishment of integrated proviral latency (GO:0075713)2.92977324
65basement membrane organization (GO:0071711)2.92773708
66chromatin assembly (GO:0031497)2.91741507
67pentose-phosphate shunt (GO:0006098)2.91449956
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.91311261
69regulation of mitotic spindle organization (GO:0060236)2.91288721
70protein maturation by protein folding (GO:0022417)2.90401299
71nuclear envelope organization (GO:0006998)2.90229022
72apoptotic process involved in morphogenesis (GO:0060561)2.90039907
73sister chromatid segregation (GO:0000819)2.87749480
74maternal placenta development (GO:0001893)2.86904613
75positive regulation of chromosome segregation (GO:0051984)2.86812101
76establishment of protein localization to endoplasmic reticulum (GO:0072599)2.85455008
77regulation of RNA export from nucleus (GO:0046831)2.85238757
78positive regulation of Cdc42 GTPase activity (GO:0043089)2.83480440
79regulation of histone H3-K9 methylation (GO:0051570)2.83044815
80positive regulation of SMAD protein import into nucleus (GO:0060391)2.82698535
81nucleobase biosynthetic process (GO:0046112)2.82672474
82adherens junction assembly (GO:0034333)2.82329352
83COPI coating of Golgi vesicle (GO:0048205)2.82286960
84Golgi transport vesicle coating (GO:0048200)2.82286960
85DNA duplex unwinding (GO:0032508)2.82187503
86macromolecular complex disassembly (GO:0032984)2.82166892
87regulation of hippo signaling (GO:0035330)2.81057182
88stress fiber assembly (GO:0043149)2.81023366
89nuclear-transcribed mRNA catabolic process (GO:0000956)2.80641698
90modulation by symbiont of host cellular process (GO:0044068)2.79646382
91IMP metabolic process (GO:0046040)2.79306975
92skin morphogenesis (GO:0043589)2.79294184
93DNA geometric change (GO:0032392)2.79220773
943-UTR-mediated mRNA stabilization (GO:0070935)2.78840859
95rRNA processing (GO:0006364)2.78811727
96peptidyl-arginine omega-N-methylation (GO:0035247)2.75894665
97RNA stabilization (GO:0043489)2.75400800
98mRNA stabilization (GO:0048255)2.75400800
99protein localization to endoplasmic reticulum (GO:0070972)2.74746405
100NADPH regeneration (GO:0006740)2.73944004
101establishment of viral latency (GO:0019043)2.73937280
102regulation of translational termination (GO:0006449)2.73101502
103cell-cell junction maintenance (GO:0045217)2.72981566
104protein localization to chromosome (GO:0034502)2.72114647
105spliceosomal snRNP assembly (GO:0000387)2.71885765
106rRNA metabolic process (GO:0016072)2.70800321
107negative regulation of RNA splicing (GO:0033119)2.68720903
108regulation of SMAD protein import into nucleus (GO:0060390)2.67789547
109protein retention in ER lumen (GO:0006621)2.67079679
110protein complex localization (GO:0031503)2.65846146
111RNA catabolic process (GO:0006401)2.65484123
112mRNA catabolic process (GO:0006402)2.65189285
113regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.64432401
114regulation of telomere maintenance via telomerase (GO:0032210)2.63865677
115pore complex assembly (GO:0046931)2.62775246
116modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.62367106
117modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.62367106
118positive regulation by organism of defense response of other organism involved in symbiotic interact2.62367106
119modulation by symbiont of host immune response (GO:0052553)2.62367106
120positive regulation by symbiont of host defense response (GO:0052509)2.62367106
121modulation by symbiont of host defense response (GO:0052031)2.62367106
122RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.61902454
123mRNA splicing, via spliceosome (GO:0000398)2.61902454
124RNA splicing, via transesterification reactions (GO:0000375)2.61669153
125regulation of chromosome segregation (GO:0051983)2.61587650
126establishment of chromosome localization (GO:0051303)2.61394577
127trophectodermal cell differentiation (GO:0001829)2.61391661
128chromatin assembly or disassembly (GO:0006333)2.60081289
129negative regulation of chromosome segregation (GO:0051985)2.59932144
130regulation of gene silencing (GO:0060968)2.58092638
131mitotic G1 DNA damage checkpoint (GO:0031571)2.57968368
132regulation of NFAT protein import into nucleus (GO:0051532)2.57748867
133folic acid metabolic process (GO:0046655)2.57636102
134cell-substrate adherens junction assembly (GO:0007045)2.57213391
135focal adhesion assembly (GO:0048041)2.57213391
136pinocytosis (GO:0006907)2.57006750
137nucleobase-containing small molecule interconversion (GO:0015949)2.56852749
138regulation of sister chromatid cohesion (GO:0007063)2.56816360
139modulation by virus of host process (GO:0019054)2.56330015
140maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.53842654
141negative regulation of mRNA processing (GO:0050686)2.52773713
142spindle checkpoint (GO:0031577)2.52348714
143trophoblast giant cell differentiation (GO:0060707)2.52331352
144regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.50153734
145telomere maintenance via semi-conservative replication (GO:0032201)2.49483130
146regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.43963834
147rRNA transcription (GO:0009303)2.42751702
148protein localization to microtubule (GO:0035372)2.41739516
149cell-substrate junction assembly (GO:0007044)2.37890929
150myeloid cell homeostasis (GO:0002262)2.36612012
151barbed-end actin filament capping (GO:0051016)2.35387239
152dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.34897468
153protein export from nucleus (GO:0006611)2.33139574
154substrate-dependent cell migration (GO:0006929)2.33053729
155regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.31178394
156positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.31178394
157regulation of nucleobase-containing compound transport (GO:0032239)2.30431111
158spliceosomal tri-snRNP complex assembly (GO:0000244)2.30264889
159neuron projection extension involved in neuron projection guidance (GO:1902284)2.29438706
160axon extension involved in axon guidance (GO:0048846)2.29438706
161pentose metabolic process (GO:0019321)2.27473009
162L-alpha-amino acid transmembrane transport (GO:1902475)2.26164332
163semaphorin-plexin signaling pathway (GO:0071526)2.25838638
164mitochondrial fusion (GO:0008053)2.23735993
165proline biosynthetic process (GO:0006561)2.20862313

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.41837683
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.95839886
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.67677611
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.25421134
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.87571535
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86577399
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59116140
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.55265885
9MYC_22102868_ChIP-Seq_BL_Human2.43429560
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.32480174
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23041293
12* XRN2_22483619_ChIP-Seq_HELA_Human2.16997007
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00794884
14* ETS1_20019798_ChIP-Seq_JURKAT_Human1.97738004
15RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89610699
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.89184681
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85069761
18* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84944631
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.84405700
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.84405700
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.84405700
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83434987
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.81896862
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79224566
25AR_21909140_ChIP-Seq_LNCAP_Human1.77344484
26LXR_22292898_ChIP-Seq_THP-1_Human1.75118972
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.74591795
28VDR_21846776_ChIP-Seq_THP-1_Human1.73393535
29* EST1_17652178_ChIP-ChIP_JURKAT_Human1.70617776
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58004429
31STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57494024
32* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.57475866
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57250828
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56736123
35* GABP_17652178_ChIP-ChIP_JURKAT_Human1.56669603
36* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54665940
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54204155
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.53251435
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.52890164
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52619482
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52528729
42* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.51544319
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50446365
44TTF2_22483619_ChIP-Seq_HELA_Human1.50361218
45* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.48516295
46VDR_23849224_ChIP-Seq_CD4+_Human1.47587088
47* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47145181
48DCP1A_22483619_ChIP-Seq_HELA_Human1.46427265
49TCF3_18692474_ChIP-Seq_MEFs_Mouse1.46271961
50KDM5A_27292631_Chip-Seq_BREAST_Human1.44474820
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44257485
52GABP_19822575_ChIP-Seq_HepG2_Human1.43808071
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40609494
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.40393268
55* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39449726
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38139683
57CLOCK_20551151_ChIP-Seq_293T_Human1.37938691
58UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36862632
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.36725909
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36272989
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35859859
62CIITA_25753668_ChIP-Seq_RAJI_Human1.35647710
63RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.34914763
64TP63_17297297_ChIP-ChIP_HaCaT_Human1.34484686
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34431174
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34058782
67TFEB_21752829_ChIP-Seq_HELA_Human1.33870768
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31382071
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29613025
70* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29174949
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28916342
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26333725
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25138824
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.24753795
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23645839
76* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22606135
77ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22263164
78PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21097074
79ATF3_27146783_Chip-Seq_COLON_Human1.20847043
80KDM2B_26808549_Chip-Seq_K562_Human1.20809991
81* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19553035
82VDR_24763502_ChIP-Seq_THP-1_Human1.17656585
83* FOXP3_21729870_ChIP-Seq_TREG_Human1.16507472
84KDM2B_26808549_Chip-Seq_DND41_Human1.14465496
85* TCF7_22412390_ChIP-Seq_EML_Mouse1.13848517
86* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12481195
87* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09884671
88TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09608784
89OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08741973
90SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07915739
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07233271
92CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06999286
93* MAF_26560356_Chip-Seq_TH1_Human1.06485621
94SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06099477
95NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05999028
96STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05436183
97* NANOG_21062744_ChIP-ChIP_HESCs_Human1.05095251
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.04898021
99* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04586384
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04486707
101HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04035663
102TCF3_18692474_ChIP-Seq_MESCs_Mouse1.03665691
103* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02975617
104KDM2B_26808549_Chip-Seq_JURKAT_Human1.02685435
105* SA1_27219007_Chip-Seq_ERYTHROID_Human1.02644706
106UTX_26944678_Chip-Seq_JUKART_Human1.02521443
107ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02411200
108* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00245472
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99623623
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99167803
111* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98918697
112NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98823144
113SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98646062
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98614635
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98599340
116ZNF263_19887448_ChIP-Seq_K562_Human0.98474574
117* TP53_22127205_ChIP-Seq_IMR90_Human0.97602270
118* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97141727
119UBF1/2_26484160_Chip-Seq_HMECs_Human0.97018011
120ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96824957
121CHD1_26751641_Chip-Seq_LNCaP_Human0.96721833
122YY1_21170310_ChIP-Seq_MESCs_Mouse0.96065510
123CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95994645
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94887160
125RACK7_27058665_Chip-Seq_MCF-7_Human0.94885249
126NCOR1_26117541_ChIP-Seq_K562_Human0.94034699
127E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93412345
128PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92719230
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91332957
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91292586

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.79448246
2MP0004957_abnormal_blastocyst_morpholog3.54616439
3MP0003111_abnormal_nucleus_morphology3.38866198
4MP0003077_abnormal_cell_cycle3.06286650
5MP0010352_gastrointestinal_tract_polyps2.68689449
6MP0004858_abnormal_nervous_system2.65514008
7MP0010094_abnormal_chromosome_stability2.65089794
8MP0003705_abnormal_hypodermis_morpholog2.62325721
9MP0008057_abnormal_DNA_replication2.50999808
10MP0008260_abnormal_autophagy2.41278490
11MP0001730_embryonic_growth_arrest2.37961410
12MP0005058_abnormal_lysosome_morphology2.36963222
13MP0005451_abnormal_body_composition2.36254904
14MP0003941_abnormal_skin_development2.34040982
15MP0008007_abnormal_cellular_replicative2.31343314
16MP0010030_abnormal_orbit_morphology2.29934054
17MP0009379_abnormal_foot_pigmentation2.26984579
18MP0000350_abnormal_cell_proliferation2.18837246
19MP0008932_abnormal_embryonic_tissue2.12540864
20MP0002877_abnormal_melanocyte_morpholog2.12363987
21MP0005076_abnormal_cell_differentiation2.05678179
22MP0003123_paternal_imprinting1.98948714
23MP0009278_abnormal_bone_marrow1.83728701
24MP0001672_abnormal_embryogenesis/_devel1.81864586
25MP0005380_embryogenesis_phenotype1.81864586
26MP0001697_abnormal_embryo_size1.78995858
27MP0002084_abnormal_developmental_patter1.77512874
28MP0002085_abnormal_embryonic_tissue1.74056072
29MP0010307_abnormal_tumor_latency1.68996327
30MP0003984_embryonic_growth_retardation1.67479344
31MP0002088_abnormal_embryonic_growth/wei1.65376439
32MP0002796_impaired_skin_barrier1.63965814
33MP0002086_abnormal_extraembryonic_tissu1.63434399
34MP0002653_abnormal_ependyma_morphology1.60281946
35MP0004197_abnormal_fetal_growth/weight/1.59579792
36MP0005023_abnormal_wound_healing1.58867457
37MP0008058_abnormal_DNA_repair1.57118540
38MP0008438_abnormal_cutaneous_collagen1.56185854
39MP0002080_prenatal_lethality1.54473800
40MP0000490_abnormal_crypts_of1.49853093
41MP0004272_abnormal_basement_membrane1.49322018
42MP0003566_abnormal_cell_adhesion1.48586016
43MP0005257_abnormal_intraocular_pressure1.48053471
44MP0001849_ear_inflammation1.45539146
45MP0003303_peritoneal_inflammation1.44910837
46MP0002254_reproductive_system_inflammat1.44107192
47MP0009053_abnormal_anal_canal1.43502487
48MP0003942_abnormal_urinary_system1.40303237
49MP0002396_abnormal_hematopoietic_system1.39845943
50MP0002089_abnormal_postnatal_growth/wei1.37763688
51MP0009333_abnormal_splenocyte_physiolog1.37165439
52MP0004185_abnormal_adipocyte_glucose1.36916920
53MP0003119_abnormal_digestive_system1.33050907
54MP0001293_anophthalmia1.31693210
55MP0004808_abnormal_hematopoietic_stem1.27484641
56MP0003567_abnormal_fetal_cardiomyocyte1.26736014
57MP0000313_abnormal_cell_death1.26173812
58MP0001545_abnormal_hematopoietic_system1.25889718
59MP0005397_hematopoietic_system_phenotyp1.25889718
60MP0000537_abnormal_urethra_morphology1.25127573
61MP0003279_aneurysm1.24567304
62MP0005409_darkened_coat_color1.23044849
63MP0003786_premature_aging1.22564820
64MP0000767_abnormal_smooth_muscle1.19425112
65MP0000579_abnormal_nail_morphology1.18610929
66MP0002019_abnormal_tumor_incidence1.18111943
67MP0003300_gastrointestinal_ulcer1.17467739
68MP0003890_abnormal_embryonic-extraembry1.15623756
69MP0003191_abnormal_cellular_cholesterol1.15161664
70MP0000733_abnormal_muscle_development1.14536203
71MP0002092_abnormal_eye_morphology1.11066064
72MP0000428_abnormal_craniofacial_morphol1.09895948
73MP0010234_abnormal_vibrissa_follicle1.05768822
74MP0000858_altered_metastatic_potential1.02516405
75MP0001915_intracranial_hemorrhage1.02509351
76MP0002060_abnormal_skin_morphology1.02133813
77MP0001542_abnormal_bone_strength1.00823053
78MP0003315_abnormal_perineum_morphology0.99634458
79MP0003436_decreased_susceptibility_to0.98796436
80MP0003937_abnormal_limbs/digits/tail_de0.98112677
81MP0002111_abnormal_tail_morphology0.96026159
82MP0009840_abnormal_foam_cell0.94960970
83MP0000762_abnormal_tongue_morphology0.94808012
84MP0003448_altered_tumor_morphology0.93926780
85MP0000534_abnormal_ureter_morphology0.93536233
86MP0000750_abnormal_muscle_regeneration0.93443051
87MP0003172_abnormal_lysosome_physiology0.93368201
88MP0003221_abnormal_cardiomyocyte_apopto0.91406769
89MP0000678_abnormal_parathyroid_gland0.90042305
90MP0005248_abnormal_Harderian_gland0.89286221
91MP0005197_abnormal_uvea_morphology0.89128536
92MP0003453_abnormal_keratinocyte_physiol0.88988632
93MP0000703_abnormal_thymus_morphology0.88848873
94MP0003718_maternal_effect0.88436436
95MP0009384_cardiac_valve_regurgitation0.87762234
96MP0004233_abnormal_muscle_weight0.86548878
97MP0000432_abnormal_head_morphology0.85984452
98MP0005623_abnormal_meninges_morphology0.85653063
99MP0004510_myositis0.85426479
100MP0002932_abnormal_joint_morphology0.84401963
101MP0002722_abnormal_immune_system0.84206442
102MP0002249_abnormal_larynx_morphology0.84131071
103MP0002925_abnormal_cardiovascular_devel0.83831168
104MP0008877_abnormal_DNA_methylation0.82967019
105MP0000467_abnormal_esophagus_morphology0.82607893
106MP0000516_abnormal_urinary_system0.82486607
107MP0005367_renal/urinary_system_phenotyp0.82486607
108MP0000015_abnormal_ear_pigmentation0.82133426
109MP0002697_abnormal_eye_size0.81576054
110MP0008770_decreased_survivor_rate0.81335485
111MP0000689_abnormal_spleen_morphology0.80858605
112MP0000358_abnormal_cell_content/0.80181169
113MP0002398_abnormal_bone_marrow0.79966606
114MP0009672_abnormal_birth_weight0.79915380
115MP0001727_abnormal_embryo_implantation0.79915084
116MP0005621_abnormal_cell_physiology0.79299755
117MP0003186_abnormal_redox_activity0.78969353
118MP0001216_abnormal_epidermal_layer0.78781381
119MP0005508_abnormal_skeleton_morphology0.78052958
120MP0003935_abnormal_craniofacial_develop0.77719529
121MP0003115_abnormal_respiratory_system0.76610113
122MP0003385_abnormal_body_wall0.76607040
123MP0002210_abnormal_sex_determination0.76374745
124MP0000477_abnormal_intestine_morphology0.75776665
125MP0003091_abnormal_cell_migration0.75635304
126MP0001145_abnormal_male_reproductive0.75626782
127MP0005501_abnormal_skin_physiology0.75393011
128MP0002405_respiratory_system_inflammati0.74610090
129MP0004133_heterotaxia0.74381787
130MP0003755_abnormal_palate_morphology0.73208108
131MP0005384_cellular_phenotype0.72113091
132MP0002277_abnormal_respiratory_mucosa0.72032107
133MP0002998_abnormal_bone_remodeling0.72032089
134MP0005193_abnormal_anterior_eye0.71981753
135MP0003828_pulmonary_edema0.71497577
136MP0009703_decreased_birth_body0.70827848
137MP0000049_abnormal_middle_ear0.70060341

Predicted human phenotypes

RankGene SetZ-score
1Vertebral compression fractures (HP:0002953)3.52597990
2Protrusio acetabuli (HP:0003179)3.40509472
3Selective tooth agenesis (HP:0001592)3.26188352
4Reticulocytopenia (HP:0001896)3.14117124
5Abnormality of cells of the erythroid lineage (HP:0012130)3.03844511
6Breast hypoplasia (HP:0003187)2.94747969
7Trismus (HP:0000211)2.93421581
8Long palpebral fissure (HP:0000637)2.85266615
9Ependymoma (HP:0002888)2.78882307
10Multiple enchondromatosis (HP:0005701)2.71699664
11Abnormality of the fetal cardiovascular system (HP:0010948)2.65651027
12Abnormal umbilical cord blood vessels (HP:0011403)2.65651027
13Single umbilical artery (HP:0001195)2.65651027
14Abnormal number of erythroid precursors (HP:0012131)2.57731901
15Rib fusion (HP:0000902)2.57217855
16Insomnia (HP:0100785)2.56170097
17Premature rupture of membranes (HP:0001788)2.55271500
18Colon cancer (HP:0003003)2.52057740
19Arnold-Chiari malformation (HP:0002308)2.51643306
20Fragile skin (HP:0001030)2.49622947
21Shallow orbits (HP:0000586)2.48946241
22Aplasia/Hypoplasia of the patella (HP:0006498)2.47325695
23Degeneration of anterior horn cells (HP:0002398)2.42823137
24Abnormality of the anterior horn cell (HP:0006802)2.42823137
25Patellar aplasia (HP:0006443)2.40473963
26Deviation of the thumb (HP:0009603)2.37936268
27Overriding aorta (HP:0002623)2.37122298
28Missing ribs (HP:0000921)2.32270245
29Proximal placement of thumb (HP:0009623)2.32258125
30Short nail (HP:0001799)2.32088814
31Ankle contracture (HP:0006466)2.31683137
32Blue sclerae (HP:0000592)2.31115875
33Thin bony cortex (HP:0002753)2.29435979
34Cerebral aneurysm (HP:0004944)2.28682626
35Genu recurvatum (HP:0002816)2.28490600
36Renal duplication (HP:0000075)2.28348687
37Ulnar bowing (HP:0003031)2.28117071
38Basal cell carcinoma (HP:0002671)2.27189305
39Aplasia/hypoplasia of the humerus (HP:0006507)2.25816637
40Back pain (HP:0003418)2.24902544
41Partial duplication of thumb phalanx (HP:0009944)2.21793383
42Abnormality of the Achilles tendon (HP:0005109)2.19515415
43Fused cervical vertebrae (HP:0002949)2.18947109
44Atresia of the external auditory canal (HP:0000413)2.17137142
45Abnormality of the distal phalanx of the thumb (HP:0009617)2.16398148
46Partial duplication of the phalanx of hand (HP:0009999)2.16214839
47Absent thumb (HP:0009777)2.15335654
48Absent radius (HP:0003974)2.15300261
49Disproportionate tall stature (HP:0001519)2.14324638
50Bladder diverticulum (HP:0000015)2.13199881
51Agnosia (HP:0010524)2.13139092
52Overlapping toe (HP:0001845)2.12957638
53Atrophic scars (HP:0001075)2.12309921
54Squamous cell carcinoma (HP:0002860)2.10997710
55Abnormality of the distal phalanges of the toes (HP:0010182)2.10740824
56Medulloblastoma (HP:0002885)2.09052623
57Abnormal trabecular bone morphology (HP:0100671)2.08529313
58Spastic diplegia (HP:0001264)2.07276611
59Carpal bone hypoplasia (HP:0001498)2.06554051
60Birth length less than 3rd percentile (HP:0003561)2.06292333
61Macrocytic anemia (HP:0001972)2.05708968
62Pallor (HP:0000980)2.05688528
63Spinal rigidity (HP:0003306)2.03938313
64Broad metatarsal (HP:0001783)2.03387672
65Malignant gastrointestinal tract tumors (HP:0006749)2.03372932
66Gastrointestinal carcinoma (HP:0002672)2.03372932
67Elfin facies (HP:0004428)2.02390828
68Neoplasm of the pancreas (HP:0002894)2.01944476
69Premature ovarian failure (HP:0008209)2.01134236
70Rhabdomyosarcoma (HP:0002859)2.00962644
71Elbow flexion contracture (HP:0002987)2.00530551
72Hyperacusis (HP:0010780)1.99643203
73Short humerus (HP:0005792)1.99510751
74Abnormality of the calcaneus (HP:0008364)1.99010928
75Hand muscle atrophy (HP:0009130)1.96349884
76Spinal cord lesions (HP:0100561)1.96178131
77Syringomyelia (HP:0003396)1.96178131
78Vertebral fusion (HP:0002948)1.96136920
79Absent forearm bone (HP:0003953)1.94308011
80Aplasia involving forearm bones (HP:0009822)1.94308011
81Rough bone trabeculation (HP:0100670)1.94254316
82Hyperparathyroidism (HP:0000843)1.93023619
83Upper motor neuron abnormality (HP:0002127)1.91301326
84Delayed cranial suture closure (HP:0000270)1.90719662
85Mitral regurgitation (HP:0001653)1.90633288
86Cerebral inclusion bodies (HP:0100314)1.90423695
87Abnormality of the phalanges of the hallux (HP:0010057)1.89868330
88Asymmetry of the thorax (HP:0001555)1.89102145
89Hypercalcemia (HP:0003072)1.88578974
90Deviation of the hallux (HP:0010051)1.88066852
91Abnormality of liposaccharide metabolism (HP:0010968)1.87990533
92Abnormality of glycosphingolipid metabolism (HP:0004343)1.87990533
93Abnormality of glycolipid metabolism (HP:0010969)1.87990533
94Cerebral hypomyelination (HP:0006808)1.87948458
95Vertebral hypoplasia (HP:0008417)1.87709001
96Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.87709001
97Distal upper limb amyotrophy (HP:0007149)1.87509021
98Upper limb amyotrophy (HP:0009129)1.87509021
99Glossoptosis (HP:0000162)1.86473302
100Slender long bone (HP:0003100)1.86298074
101Abnormality of the astrocytes (HP:0100707)1.86223064
102Astrocytoma (HP:0009592)1.86223064
103Short 4th metacarpal (HP:0010044)1.85233427
104Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85233427
105Abnormal number of incisors (HP:0011064)1.82704295
106Nuclear cataract (HP:0100018)1.82685676
107Poikiloderma (HP:0001029)1.82426913
108Deep palmar crease (HP:0006191)1.81209134
109Facial hemangioma (HP:0000329)1.81118067
110Sparse lateral eyebrow (HP:0005338)1.80879090
111Preauricular skin tag (HP:0000384)1.80756853
112Pathologic fracture (HP:0002756)1.80067636
113Abnormality of the thoracic spine (HP:0100711)1.80003876
114Hallux valgus (HP:0001822)1.79969864
115Generalized amyotrophy (HP:0003700)1.79752377
116Arterial tortuosity (HP:0005116)1.79463260
117Abnormality of dentin (HP:0010299)1.79300804
118Oral leukoplakia (HP:0002745)1.79289155
119Increased connective tissue (HP:0009025)1.79156578
120Difficulty climbing stairs (HP:0003551)1.78873480
121Progressive external ophthalmoplegia (HP:0000590)1.78833307
122Natal tooth (HP:0000695)1.78090980
123Bicuspid aortic valve (HP:0001647)1.77139834
124Osteolytic defects of the phalanges of the hand (HP:0009771)1.76631295
125Osteolytic defects of the hand bones (HP:0009699)1.76631295
126Microretrognathia (HP:0000308)1.76508218
127Skin tags (HP:0010609)1.75857413
128Secondary amenorrhea (HP:0000869)1.75542761
129Broad thumb (HP:0011304)1.75083120
130Cutaneous melanoma (HP:0012056)1.74287516
131Achilles tendon contracture (HP:0001771)1.73231517
132Abnormalities of placenta or umbilical cord (HP:0001194)1.72700336
133Patellar dislocation (HP:0002999)1.72206112
134Neoplasm of striated muscle (HP:0009728)1.71835655
135Abnormal vertebral ossification (HP:0100569)1.71469794
136Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.69607946
137Hyperextensible skin (HP:0000974)1.69227210
138Rectal prolapse (HP:0002035)1.68742123
139Wrist flexion contracture (HP:0001239)1.68629230
140Increased density of long bones (HP:0006392)1.68550014
141Distal lower limb muscle weakness (HP:0009053)1.68509088
142Abnormality of the umbilical cord (HP:0010881)1.68474641
143Multiple lipomas (HP:0001012)1.68081439
144Esophageal atresia (HP:0002032)1.67407619
145Mitral valve prolapse (HP:0001634)1.66982079
146Tracheoesophageal fistula (HP:0002575)1.66527820
147Increased nuchal translucency (HP:0010880)1.65801550
148Congenital glaucoma (HP:0001087)1.65744222
149Abnormal hemoglobin (HP:0011902)1.65586070
150Vascular tortuosity (HP:0004948)1.65344088
151Entropion (HP:0000621)1.65108965
152High anterior hairline (HP:0009890)1.65011595
153Abnormality of the ileum (HP:0001549)1.64353812
154Abnormal ossification of hand bones (HP:0005921)1.64118381
155Flat acetabular roof (HP:0003180)1.64004191
156Biconcave vertebral bodies (HP:0004586)1.63936396
157Personality changes (HP:0000751)1.63888340
158Dilatation of the ascending aorta (HP:0005111)1.63155172
159Meckel diverticulum (HP:0002245)1.62001563
160Myelodysplasia (HP:0002863)1.61812808
161Broad distal phalanx of finger (HP:0009836)1.61444247
162Atrophy/Degeneration involving motor neurons (HP:0007373)1.60905480
163Carpal synostosis (HP:0009702)1.60786255
164Adenoma sebaceum (HP:0009720)1.60475401
165Angiofibromas (HP:0010615)1.60475401
166Calcaneovalgus deformity (HP:0001848)1.59680194
167Cervical subluxation (HP:0003308)1.59341960
168Progressive muscle weakness (HP:0003323)1.58447159
169Spinal muscular atrophy (HP:0007269)1.58040730
170Aplasia/Hypoplasia of the sacrum (HP:0008517)1.58015738
171Joint laxity (HP:0001388)1.57149061
172Myelomeningocele (HP:0002475)1.56452909
173Thoracic kyphosis (HP:0002942)1.56113187
174Pseudobulbar signs (HP:0002200)1.52105916

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.90252788
2BUB13.83422056
3CDK122.87074985
4NEK22.85095058
5WEE12.82271240
6CDC72.75539795
7MAP3K102.67568541
8SIK12.62996803
9IRAK32.61885732
10LATS22.60232385
11PRPF4B2.55502780
12TRIB32.48703406
13EEF2K2.41470824
14TESK22.20917648
15NME22.12801965
16VRK22.09775940
17RPS6KA42.02034581
18PKN21.89231017
19TTK1.77464413
20STK101.75128364
21TAF11.69519489
22PAK41.65448978
23CDK71.63651365
24TAOK21.59510497
25RPS6KB21.59004242
26TLK11.56474876
27ALK1.49643867
28PLK11.47683489
29EPHA21.47574870
30ARAF1.46836256
31ACVR1B1.46204326
32DYRK31.44407797
33CDK41.41036595
34MAP3K81.39209519
35MAP3K91.28906206
36LATS11.28752262
37PBK1.27078289
38LRRK21.25215974
39EIF2AK11.21940259
40CAMK1G1.18559689
41CAMK1D1.17782847
42AURKB1.17400828
43BRAF1.15461227
44SCYL21.14725293
45SRPK11.14124604
46MAP4K11.13821344
47PIM11.12847667
48STK31.10336133
49BMX1.09960871
50AURKA1.09179487
51CHEK21.08555591
52MAP3K111.06413901
53BRSK21.06305871
54ERN11.05845117
55ICK1.04685675
56TGFBR11.02976000
57TTN1.02175154
58MTOR1.01959484
59TSSK60.99208918
60TYRO30.98940942
61STK160.98882920
62CHEK10.98616275
63PASK0.98252918
64EPHB20.94248909
65GRK60.93721072
66NEK10.93324774
67DDR20.93289818
68PAK10.92197233
69CDK60.92190192
70MKNK10.90615712
71PDGFRA0.89550285
72DMPK0.87927675
73MAP3K10.87670486
74ATR0.86749508
75PAK20.86225356
76FGFR40.86015906
77MARK30.85221094
78PRKD20.84232837
79TAOK10.81066265
80STK40.80140669
81MAP2K30.79275429
82CDK20.76920962
83IRAK40.76413278
84ERBB40.76138119
85TGFBR20.76052118
86STK38L0.73797887
87PRKD30.70592805
88PIM20.69762057
89PRKG20.69696398
90MAPKAPK30.69044689
91PTK60.68549305
92MELK0.68047252
93NTRK10.67609812
94EPHB10.66335204
95MAP2K20.66056664
96ABL20.65996635
97RIPK10.65220593
98MAP3K30.62857398
99RPS6KA20.61462483
100ATM0.59201983
101MARK20.59149304
102RPS6KC10.58849411
103RPS6KL10.58849411
104ILK0.58167930
105KDR0.58153448
106MKNK20.57227743
107TESK10.57209623
108PNCK0.56496974
109PLK30.54334510
110FGFR10.53717926
111DAPK30.53464965
112CSK0.52120820
113DYRK1B0.51816908
114ZAP700.49781358
115CDC42BPA0.49152344
116MATK0.48465127
117IRAK20.48080911
118CSF1R0.47327820
119PTK20.45192677
120MOS0.45120502
121BRD40.45083207
122CSNK2A20.45019843
123KSR20.44505154
124JAK30.44209645
125LIMK10.43668877
126BRSK10.43497435
127RPS6KA10.43478313
128CDK10.43409429
129CSNK1E0.41758297
130PRKCI0.41505073
131MET0.40998354
132CDK90.40818469
133PDPK10.40266433
134CDK80.39868837
135SIK30.38978565
136CLK10.38863757
137AKT20.38821498
138RAF10.38607637
139FGR0.38303971
140STK240.37304168
141CDK11A0.36693739

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.35074479
2Ribosome_Homo sapiens_hsa030103.27981715
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.27161740
4RNA transport_Homo sapiens_hsa030133.05083575
5Spliceosome_Homo sapiens_hsa030403.05062131
6Mismatch repair_Homo sapiens_hsa034302.83545777
7Cell cycle_Homo sapiens_hsa041102.56705673
8RNA polymerase_Homo sapiens_hsa030202.39887101
9Base excision repair_Homo sapiens_hsa034102.30968828
10One carbon pool by folate_Homo sapiens_hsa006702.18511309
11Nucleotide excision repair_Homo sapiens_hsa034202.10076861
12mRNA surveillance pathway_Homo sapiens_hsa030152.03246456
13Proteasome_Homo sapiens_hsa030501.94995654
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88781345
15Homologous recombination_Homo sapiens_hsa034401.85539570
16p53 signaling pathway_Homo sapiens_hsa041151.72049356
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54441271
18Other glycan degradation_Homo sapiens_hsa005111.52436099
19Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.51927179
20Pyrimidine metabolism_Homo sapiens_hsa002401.50587245
21Basal transcription factors_Homo sapiens_hsa030221.38516557
22MicroRNAs in cancer_Homo sapiens_hsa052061.38500705
23Fanconi anemia pathway_Homo sapiens_hsa034601.34452776
24Viral carcinogenesis_Homo sapiens_hsa052031.31025059
25Epstein-Barr virus infection_Homo sapiens_hsa051691.28217832
26Notch signaling pathway_Homo sapiens_hsa043301.27165071
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27043632
28RNA degradation_Homo sapiens_hsa030181.24726385
29Small cell lung cancer_Homo sapiens_hsa052221.23694897
30Hippo signaling pathway_Homo sapiens_hsa043901.22140681
31Antigen processing and presentation_Homo sapiens_hsa046121.21240487
32Chronic myeloid leukemia_Homo sapiens_hsa052201.20841773
33Bladder cancer_Homo sapiens_hsa052191.17077541
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15602325
35Vibrio cholerae infection_Homo sapiens_hsa051101.15086866
36TGF-beta signaling pathway_Homo sapiens_hsa043501.12085064
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10892558
38HTLV-I infection_Homo sapiens_hsa051661.10734169
39Prion diseases_Homo sapiens_hsa050201.10311237
40Lysosome_Homo sapiens_hsa041421.08215308
41Herpes simplex infection_Homo sapiens_hsa051681.05160998
42Shigellosis_Homo sapiens_hsa051311.03937714
43Thyroid cancer_Homo sapiens_hsa052161.03622744
44Oocyte meiosis_Homo sapiens_hsa041141.01054797
45Systemic lupus erythematosus_Homo sapiens_hsa053221.00911703
46Apoptosis_Homo sapiens_hsa042101.00529786
47Basal cell carcinoma_Homo sapiens_hsa052171.00379600
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97866900
49Colorectal cancer_Homo sapiens_hsa052100.94422438
50Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92569915
51Melanoma_Homo sapiens_hsa052180.91338571
52Galactose metabolism_Homo sapiens_hsa000520.91261035
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90638500
54Glioma_Homo sapiens_hsa052140.90554547
55Adherens junction_Homo sapiens_hsa045200.89825922
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88777510
57Proteoglycans in cancer_Homo sapiens_hsa052050.88345715
58mTOR signaling pathway_Homo sapiens_hsa041500.86640831
59Hepatitis C_Homo sapiens_hsa051600.83515708
60Hedgehog signaling pathway_Homo sapiens_hsa043400.81685204
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81255631
62ErbB signaling pathway_Homo sapiens_hsa040120.80580973
63Acute myeloid leukemia_Homo sapiens_hsa052210.79932794
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79912220
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78618209
66Legionellosis_Homo sapiens_hsa051340.77774284
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77316966
68Pancreatic cancer_Homo sapiens_hsa052120.76276774
69Vitamin B6 metabolism_Homo sapiens_hsa007500.74542866
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.73539646
71Folate biosynthesis_Homo sapiens_hsa007900.73198200
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73038900
73Non-homologous end-joining_Homo sapiens_hsa034500.71583812
74Hepatitis B_Homo sapiens_hsa051610.70902984
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.70851943
76Sulfur relay system_Homo sapiens_hsa041220.70743420
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70197651
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69872249
79Pathways in cancer_Homo sapiens_hsa052000.69385101
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68625608
81Viral myocarditis_Homo sapiens_hsa054160.68395749
82N-Glycan biosynthesis_Homo sapiens_hsa005100.68169657
83Insulin signaling pathway_Homo sapiens_hsa049100.67989580
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67898912
85B cell receptor signaling pathway_Homo sapiens_hsa046620.65150674
86Pentose phosphate pathway_Homo sapiens_hsa000300.65093276
87Renal cell carcinoma_Homo sapiens_hsa052110.64802300
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63627661
89HIF-1 signaling pathway_Homo sapiens_hsa040660.62817071
90Prostate cancer_Homo sapiens_hsa052150.62031355
91Leishmaniasis_Homo sapiens_hsa051400.61954782
92VEGF signaling pathway_Homo sapiens_hsa043700.61670471
93Focal adhesion_Homo sapiens_hsa045100.60155788
94Phagosome_Homo sapiens_hsa041450.59683961
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.59516239
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59364471
97Biosynthesis of amino acids_Homo sapiens_hsa012300.59009412
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58814334
99Non-small cell lung cancer_Homo sapiens_hsa052230.58369031
100Selenocompound metabolism_Homo sapiens_hsa004500.58205662
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57209997
102Influenza A_Homo sapiens_hsa051640.56987188
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56074774
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55606151
105Rap1 signaling pathway_Homo sapiens_hsa040150.55464276
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54920643
107Malaria_Homo sapiens_hsa051440.54591062
108Tight junction_Homo sapiens_hsa045300.54384594
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.54129858
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.53110861
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.52567377
112Fructose and mannose metabolism_Homo sapiens_hsa000510.52448380
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51894121
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.51742028
115Toxoplasmosis_Homo sapiens_hsa051450.47414657
116Purine metabolism_Homo sapiens_hsa002300.47389942
117Measles_Homo sapiens_hsa051620.44965271
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44195902
119Endometrial cancer_Homo sapiens_hsa052130.43837413
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42611731
121TNF signaling pathway_Homo sapiens_hsa046680.41848696
122Wnt signaling pathway_Homo sapiens_hsa043100.40866331
123Osteoclast differentiation_Homo sapiens_hsa043800.40089006
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39699701
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.39354759
126ECM-receptor interaction_Homo sapiens_hsa045120.38704068
127Amoebiasis_Homo sapiens_hsa051460.38636305
128Salmonella infection_Homo sapiens_hsa051320.38369085
129Endocytosis_Homo sapiens_hsa041440.37639230
130Primary immunodeficiency_Homo sapiens_hsa053400.37036075

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