PHF24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.12580398
2synaptic vesicle maturation (GO:0016188)5.88276252
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.67286688
4glutamate secretion (GO:0014047)5.48481526
5synaptic vesicle exocytosis (GO:0016079)5.28880482
6regulation of synaptic vesicle exocytosis (GO:2000300)5.03736324
7neuronal action potential propagation (GO:0019227)5.03454632
8locomotory exploration behavior (GO:0035641)4.99011072
9L-amino acid import (GO:0043092)4.92670605
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.75118603
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.73234302
12negative regulation of dendrite morphogenesis (GO:0050774)4.72180428
13positive regulation of synapse maturation (GO:0090129)4.60966802
14regulation of synaptic vesicle transport (GO:1902803)4.44724168
15cerebellar granule cell differentiation (GO:0021707)4.44709033
16proline transport (GO:0015824)4.43954140
17regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.38470474
18vocalization behavior (GO:0071625)4.37620135
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.35002327
20amino acid import (GO:0043090)4.34883468
21protein localization to synapse (GO:0035418)4.32811965
22cellular potassium ion homeostasis (GO:0030007)4.13717913
23positive regulation of dendritic spine development (GO:0060999)4.12337732
24regulation of neuronal synaptic plasticity (GO:0048168)4.09940837
25regulation of synapse structural plasticity (GO:0051823)4.08953631
26regulation of glutamate receptor signaling pathway (GO:1900449)4.06702375
27exploration behavior (GO:0035640)4.04367795
28ionotropic glutamate receptor signaling pathway (GO:0035235)4.04358004
29layer formation in cerebral cortex (GO:0021819)4.03428058
30neurotransmitter secretion (GO:0007269)4.02862878
31membrane depolarization during action potential (GO:0086010)4.01391423
32neuron cell-cell adhesion (GO:0007158)3.99412993
33positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.97721786
34positive regulation of synaptic transmission, GABAergic (GO:0032230)3.94660104
35cell migration in hindbrain (GO:0021535)3.90491176
36positive regulation of dendritic spine morphogenesis (GO:0061003)3.90297881
37neuronal action potential (GO:0019228)3.88285692
38gamma-aminobutyric acid signaling pathway (GO:0007214)3.86457081
39negative regulation of dendrite development (GO:2000171)3.84580897
40regulation of long-term neuronal synaptic plasticity (GO:0048169)3.84454949
41postsynaptic membrane organization (GO:0001941)3.84361258
42sodium ion export (GO:0071436)3.83612661
43axon ensheathment in central nervous system (GO:0032291)3.83082265
44central nervous system myelination (GO:0022010)3.83082265
45potassium ion import (GO:0010107)3.78152386
46potassium ion homeostasis (GO:0055075)3.77743574
47synaptic transmission, glutamatergic (GO:0035249)3.74951602
48negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.74182377
49G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.72435733
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.71261909
51adenosine receptor signaling pathway (GO:0001973)3.69963655
52regulation of ARF protein signal transduction (GO:0032012)3.65771973
53regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.63387936
54regulation of dendritic spine development (GO:0060998)3.62651804
55regulation of synapse maturation (GO:0090128)3.62403982
56neuron-neuron synaptic transmission (GO:0007270)3.59693759
57prepulse inhibition (GO:0060134)3.55861058
58gamma-aminobutyric acid transport (GO:0015812)3.55174360
59activation of protein kinase A activity (GO:0034199)3.45942163
60glutamate receptor signaling pathway (GO:0007215)3.45271590
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.44989170
62regulation of excitatory postsynaptic membrane potential (GO:0060079)3.41674383
63neuromuscular process controlling balance (GO:0050885)3.41619732
64negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.39730134
65dendritic spine organization (GO:0097061)3.37594040
66membrane repolarization (GO:0086009)3.35677986
67regulation of synaptic transmission (GO:0050804)3.34930260
68regulation of neurotransmitter secretion (GO:0046928)3.33272371
69cerebellar Purkinje cell differentiation (GO:0021702)3.32288217
70regulation of synaptic plasticity (GO:0048167)3.31186354
71acidic amino acid transport (GO:0015800)3.30729310
72glucose 6-phosphate metabolic process (GO:0051156)3.29779921
73long-term synaptic potentiation (GO:0060291)3.28118661
74vesicle docking involved in exocytosis (GO:0006904)3.26097188
75neurotransmitter-gated ion channel clustering (GO:0072578)3.25938351
76membrane depolarization (GO:0051899)3.25549024
77neurotransmitter transport (GO:0006836)3.25298475
78chemosensory behavior (GO:0007635)3.25294623
79vesicle transport along microtubule (GO:0047496)3.22937947
80regulation of postsynaptic membrane potential (GO:0060078)3.22424794
81synaptic vesicle transport (GO:0048489)3.21288759
82establishment of synaptic vesicle localization (GO:0097480)3.21288759
83dendritic spine morphogenesis (GO:0060997)3.19821649
84neuromuscular synaptic transmission (GO:0007274)3.19239400
85positive regulation of membrane potential (GO:0045838)3.19045055
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.18103931
87positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.18096964
88innervation (GO:0060384)3.17111864
89serotonin metabolic process (GO:0042428)3.14435762
90regulation of exocytosis (GO:0017157)3.13109961
91positive regulation of potassium ion transmembrane transport (GO:1901381)3.13001789
92negative regulation of microtubule polymerization (GO:0031115)3.10706662
93calcium ion-dependent exocytosis (GO:0017156)3.10622598
94regulation of synaptic transmission, glutamatergic (GO:0051966)3.09427801
95regulation of vesicle fusion (GO:0031338)3.08947988
96mating behavior (GO:0007617)3.08403852
97regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.08371662
98regulation of voltage-gated calcium channel activity (GO:1901385)3.06048407
99membrane hyperpolarization (GO:0060081)3.05617604
100regulation of neurotransmitter transport (GO:0051588)3.03722087
101axon cargo transport (GO:0008088)3.03292245
102neurotransmitter uptake (GO:0001504)3.03278270
103detection of calcium ion (GO:0005513)3.03273294
104vesicle docking (GO:0048278)3.02628035
105phosphorelay signal transduction system (GO:0000160)3.02306586
106positive regulation of dendrite development (GO:1900006)3.02112077
107cell communication involved in cardiac conduction (GO:0086065)3.02056887
108auditory behavior (GO:0031223)3.01993829
109neuromuscular process controlling posture (GO:0050884)3.01021786
110regulation of dendritic spine morphogenesis (GO:0061001)3.00104612
111regulation of neurotransmitter levels (GO:0001505)2.99547954
112glycine transport (GO:0015816)2.99337071
113positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.98198165
114positive regulation of neurotransmitter secretion (GO:0001956)2.97819421
115cell communication by electrical coupling (GO:0010644)2.97524929
116positive regulation of neurotransmitter transport (GO:0051590)2.96554555
117regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.95841709
118detection of temperature stimulus involved in sensory perception (GO:0050961)2.94820253
119detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.94820253
120cellular sodium ion homeostasis (GO:0006883)2.92782091
121synaptic transmission (GO:0007268)2.91140247
122organelle transport along microtubule (GO:0072384)2.90089496
123neuromuscular process (GO:0050905)2.89799091
124long-term memory (GO:0007616)2.89020964
125neuronal ion channel clustering (GO:0045161)2.88351864
126regulation of amyloid precursor protein catabolic process (GO:1902991)2.87994716
127transmission of nerve impulse (GO:0019226)2.87196610
128dendrite morphogenesis (GO:0048813)2.87083962
129negative regulation of cation channel activity (GO:2001258)2.86848856
130behavioral response to pain (GO:0048266)2.86745471
131alanine transport (GO:0032328)2.84788428
132synaptic vesicle endocytosis (GO:0048488)2.83916712
133negative regulation of synaptic transmission, GABAergic (GO:0032229)2.83475147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.28889717
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.23041604
3GBX2_23144817_ChIP-Seq_PC3_Human3.09113120
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05150175
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02558214
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.94306453
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.94306453
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.93624224
9REST_21632747_ChIP-Seq_MESCs_Mouse2.67746589
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63773500
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63037423
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.60628015
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.58690083
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.54997336
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53680632
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42981468
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.30401803
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.29788422
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29681803
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.28328594
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.28116588
22DROSHA_22980978_ChIP-Seq_HELA_Human2.24190658
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.16747248
24TAF15_26573619_Chip-Seq_HEK293_Human2.12649840
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07382580
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88709840
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85726543
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79709781
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.76834756
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76046921
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67138003
32SMAD4_21799915_ChIP-Seq_A2780_Human1.65607760
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65184634
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63441408
35NR3C1_23031785_ChIP-Seq_PC12_Mouse1.56294739
36AR_21572438_ChIP-Seq_LNCaP_Human1.45924252
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43837309
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42730024
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.42570686
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37302718
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36589404
42P300_19829295_ChIP-Seq_ESCs_Human1.33085016
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32963709
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.31588370
45RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30110225
46KDM2B_26808549_Chip-Seq_K562_Human1.29268456
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28142488
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26284042
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24346988
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.23782659
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.22554101
52AHR_22903824_ChIP-Seq_MCF-7_Human1.21681629
53ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21348155
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16833189
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16304815
56P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15415878
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.13945715
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.13388310
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12435947
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12323243
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11917190
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11336137
63STAT3_23295773_ChIP-Seq_U87_Human1.11250037
64AR_19668381_ChIP-Seq_PC3_Human1.10908001
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10636571
66AR_25329375_ChIP-Seq_VCAP_Human1.10583683
67CTCF_27219007_Chip-Seq_Bcells_Human1.08981093
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08710145
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08348263
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.07264109
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.07156321
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06958240
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05879528
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05223881
75ZNF274_21170338_ChIP-Seq_K562_Hela1.04759818
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02895337
77OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02691836
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.02269031
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01295046
80SMAD3_21741376_ChIP-Seq_ESCs_Human1.00497647
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00189372
82PIAS1_25552417_ChIP-Seq_VCAP_Human0.98969809
83SMAD4_21741376_ChIP-Seq_HESCs_Human0.98637910
84YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98546815
85TET1_21490601_ChIP-Seq_MESCs_Mouse0.97638345
86RING1B_27294783_Chip-Seq_NPCs_Mouse0.97083521
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96212150
88CBX2_27304074_Chip-Seq_ESCs_Mouse0.95747547
89EGR1_19032775_ChIP-ChIP_M12_Human0.94344056
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93635512
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93510020
92TCF4_23295773_ChIP-Seq_U87_Human0.92879367
93OCT4_19829295_ChIP-Seq_ESCs_Human0.92778291
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91518185
95RXR_22108803_ChIP-Seq_LS180_Human0.91365970
96VDR_22108803_ChIP-Seq_LS180_Human0.88405206
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88315506
98DPY_21335234_ChIP-Seq_ESCs_Mouse0.88076062
99RUNX2_22187159_ChIP-Seq_PCA_Human0.87096868
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.87077046
101RNF2_27304074_Chip-Seq_NSC_Mouse0.86041151
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84804416
103KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83179545
104RBPJ_22232070_ChIP-Seq_NCS_Mouse0.82867004
105TP53_18474530_ChIP-ChIP_U2OS_Human0.82782668
106CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82721231
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82643532
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82564316
109SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81809480
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81804368
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81804368
112KLF4_19829295_ChIP-Seq_ESCs_Human0.81791073
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80855374
114LXR_22292898_ChIP-Seq_THP-1_Human0.80374901
115GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80252697
116SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80085476
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80028067
118RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.79216161
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78828461
120SMAD4_21741376_ChIP-Seq_ESCs_Human0.76061631
121SMC4_20622854_ChIP-Seq_HELA_Human0.75825237
122TP53_20018659_ChIP-ChIP_R1E_Mouse0.75628723
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.73005083

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.25890836
2MP0001968_abnormal_touch/_nociception4.99806279
3MP0003880_abnormal_central_pattern4.45952367
4MP0002736_abnormal_nociception_after4.38756394
5MP0004270_analgesia4.19107043
6MP0002735_abnormal_chemical_nociception4.03662598
7MP0003635_abnormal_synaptic_transmissio3.84223240
8MP0002734_abnormal_mechanical_nocicepti3.41016776
9MP0002733_abnormal_thermal_nociception3.09417478
10MP0009745_abnormal_behavioral_response2.98970295
11MP0002063_abnormal_learning/memory/cond2.91670792
12MP0002064_seizures2.91182628
13MP0001970_abnormal_pain_threshold2.81580828
14MP0002272_abnormal_nervous_system2.69699564
15MP0002822_catalepsy2.68016241
16MP0009046_muscle_twitch2.65293972
17MP0004858_abnormal_nervous_system2.58779020
18MP0005423_abnormal_somatic_nervous2.47597871
19MP0002572_abnormal_emotion/affect_behav2.43625321
20MP0006276_abnormal_autonomic_nervous2.18378353
21MP0002067_abnormal_sensory_capabilities2.12781164
22MP0001486_abnormal_startle_reflex2.10999138
23MP0001501_abnormal_sleep_pattern1.90678789
24MP0001440_abnormal_grooming_behavior1.86706670
25MP0003329_amyloid_beta_deposits1.85592404
26MP0009780_abnormal_chondrocyte_physiolo1.84636047
27MP0002184_abnormal_innervation1.81630444
28MP0004811_abnormal_neuron_physiology1.80984698
29MP0003123_paternal_imprinting1.67405561
30MP0008569_lethality_at_weaning1.60057991
31MP0000955_abnormal_spinal_cord1.59658315
32MP0002909_abnormal_adrenal_gland1.54085941
33MP0005386_behavior/neurological_phenoty1.53709925
34MP0004924_abnormal_behavior1.53709925
35MP0001986_abnormal_taste_sensitivity1.47679609
36MP0002557_abnormal_social/conspecific_i1.46660668
37MP0000778_abnormal_nervous_system1.44816990
38MP0003879_abnormal_hair_cell1.43085505
39MP0002882_abnormal_neuron_morphology1.37290783
40MP0003633_abnormal_nervous_system1.34365974
41MP0002066_abnormal_motor_capabilities/c1.30362304
42MP0001984_abnormal_olfaction1.29392231
43MP0000751_myopathy1.25590891
44MP0008877_abnormal_DNA_methylation1.23058076
45MP0003183_abnormal_peptide_metabolism1.18480311
46MP0001905_abnormal_dopamine_level1.11167534
47MP0003631_nervous_system_phenotype1.06490613
48MP0008874_decreased_physiological_sensi1.05990186
49MP0000569_abnormal_digit_pigmentation1.05813132
50MP0008961_abnormal_basal_metabolism0.99601092
51MP0005646_abnormal_pituitary_gland0.99464445
52MP0002229_neurodegeneration0.96253971
53MP0004885_abnormal_endolymph0.96041410
54MP0002638_abnormal_pupillary_reflex0.93066182
55MP0000604_amyloidosis0.91513499
56MP0004142_abnormal_muscle_tone0.90375224
57MP0008872_abnormal_physiological_respon0.89634975
58MP0001188_hyperpigmentation0.86236920
59MP0002152_abnormal_brain_morphology0.84885674
60MP0002837_dystrophic_cardiac_calcinosis0.84789570
61MP0005535_abnormal_body_temperature0.83061705
62MP0003634_abnormal_glial_cell0.82545918
63MP0001529_abnormal_vocalization0.80636657
64MP0000920_abnormal_myelination0.80588185
65MP0001664_abnormal_digestion0.80305830
66MP0002069_abnormal_eating/drinking_beha0.79864554
67MP0002751_abnormal_autonomic_nervous0.79364687
68MP0003283_abnormal_digestive_organ0.79228967
69MP0001485_abnormal_pinna_reflex0.79083513
70MP0004147_increased_porphyrin_level0.78564626
71MP0001502_abnormal_circadian_rhythm0.78166520
72MP0004085_abnormal_heartbeat0.77906441
73MP0004510_myositis0.77174665
74MP0001346_abnormal_lacrimal_gland0.76649430
75MP0001177_atelectasis0.76144176
76MP0000013_abnormal_adipose_tissue0.74069155
77MP0005645_abnormal_hypothalamus_physiol0.72963424
78MP0003075_altered_response_to0.72248816
79MP0002752_abnormal_somatic_nervous0.71926930
80MP0001299_abnormal_eye_distance/0.69959364
81MP0004130_abnormal_muscle_cell0.69283203
82MP0001348_abnormal_lacrimal_gland0.69113215
83MP0004742_abnormal_vestibular_system0.67858255
84MP0005623_abnormal_meninges_morphology0.67083504
85MP0003121_genomic_imprinting0.66581858
86MP0002163_abnormal_gland_morphology0.66499071
87MP0004145_abnormal_muscle_electrophysio0.62312205
88MP0003045_fibrosis0.61799589
89MP0003690_abnormal_glial_cell0.60998839
90MP0005083_abnormal_biliary_tract0.60959474
91MP0000747_muscle_weakness0.59763364
92MP0010234_abnormal_vibrissa_follicle0.58671527
93MP0001963_abnormal_hearing_physiology0.58102603
94MP0003632_abnormal_nervous_system0.56922539
95MP0005499_abnormal_olfactory_system0.55173595
96MP0005394_taste/olfaction_phenotype0.55173595
97MP0010386_abnormal_urinary_bladder0.54888912
98MP0005551_abnormal_eye_electrophysiolog0.54263291
99MP0000639_abnormal_adrenal_gland0.54066226
100MP0010769_abnormal_survival0.53204842
101MP0000749_muscle_degeneration0.52730766
102MP0003172_abnormal_lysosome_physiology0.52542593
103MP0003787_abnormal_imprinting0.52540484
104MP0003656_abnormal_erythrocyte_physiolo0.52466227
105MP0003122_maternal_imprinting0.52251249
106MP0002876_abnormal_thyroid_physiology0.51964310
107MP0003137_abnormal_impulse_conducting0.51108824
108MP0010768_mortality/aging0.50621784
109MP0001943_abnormal_respiration0.50065628
110MP0005409_darkened_coat_color0.49477968
111MP0005167_abnormal_blood-brain_barrier0.48914147
112MP0008260_abnormal_autophagy0.48791021
113MP0002082_postnatal_lethality0.48352791
114MP0010770_preweaning_lethality0.48352791
115MP0003956_abnormal_body_size0.47808254
116MP0003861_abnormal_nervous_system0.47407679
117MP0005166_decreased_susceptibility_to0.44549467
118MP0000579_abnormal_nail_morphology0.42612996
119MP0000026_abnormal_inner_ear0.42134533
120MP0002090_abnormal_vision0.42008966

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.20706332
2Focal motor seizures (HP:0011153)5.98955731
3Peripheral hypomyelination (HP:0007182)5.68081906
4Decreased number of large peripheral myelinated nerve fibers (HP:0003387)5.43501826
5Cholecystitis (HP:0001082)5.17081143
6Abnormal gallbladder physiology (HP:0012438)5.17081143
7Focal seizures (HP:0007359)5.14877097
8Action tremor (HP:0002345)4.82733331
9Diplopia (HP:0000651)4.72081903
10Abnormality of binocular vision (HP:0011514)4.72081903
11Atonic seizures (HP:0010819)4.13324397
12Visual hallucinations (HP:0002367)4.11995412
13Progressive cerebellar ataxia (HP:0002073)4.07179508
14Febrile seizures (HP:0002373)3.96665657
15Epileptic encephalopathy (HP:0200134)3.81408216
16Ankle clonus (HP:0011448)3.46361171
17Ulnar claw (HP:0001178)3.42989092
18Supranuclear gaze palsy (HP:0000605)3.39282412
19Termporal pattern (HP:0011008)3.35311564
20Insidious onset (HP:0003587)3.35311564
21Cerebral inclusion bodies (HP:0100314)3.34794126
22Absence seizures (HP:0002121)3.32899794
23Generalized tonic-clonic seizures (HP:0002069)3.29668215
24Cerebral hypomyelination (HP:0006808)3.29299075
25Status epilepticus (HP:0002133)3.22251336
26Hemiplegia (HP:0002301)3.19419774
27Pheochromocytoma (HP:0002666)3.19081391
28Depression (HP:0000716)3.18319830
29Tetraplegia (HP:0002445)3.17969466
30Intention tremor (HP:0002080)3.12564419
31Dialeptic seizures (HP:0011146)3.12117973
32Delusions (HP:0000746)3.08708975
33Urinary bladder sphincter dysfunction (HP:0002839)3.04616800
34Obstructive sleep apnea (HP:0002870)3.04558934
35Neuronal loss in central nervous system (HP:0002529)2.99118447
36Gaze-evoked nystagmus (HP:0000640)2.96819772
37Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.95963311
38Degeneration of the lateral corticospinal tracts (HP:0002314)2.95963311
39Epileptiform EEG discharges (HP:0011182)2.88261929
40Amblyopia (HP:0000646)2.84101312
41Cutaneous finger syndactyly (HP:0010554)2.82327860
42Papilledema (HP:0001085)2.79907679
43Neuroendocrine neoplasm (HP:0100634)2.77368870
44Truncal ataxia (HP:0002078)2.74373808
45Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.71769102
46Clonus (HP:0002169)2.69973440
47Urinary urgency (HP:0000012)2.67748690
48Abnormality of pain sensation (HP:0010832)2.62005394
49Impaired pain sensation (HP:0007328)2.62005394
50Impaired vibration sensation in the lower limbs (HP:0002166)2.61224512
51Decreased motor nerve conduction velocity (HP:0003431)2.60460898
52Apathy (HP:0000741)2.58471394
53Bilateral microphthalmos (HP:0007633)2.58434468
54Poor eye contact (HP:0000817)2.55873048
55Anxiety (HP:0000739)2.54716531
56Distal arthrogryposis (HP:0005684)2.54681824
57Focal dystonia (HP:0004373)2.52392432
58Dysmetria (HP:0001310)2.52138201
59Hemiparesis (HP:0001269)2.51418171
60Absent eyebrow (HP:0002223)2.49649196
61Submucous cleft hard palate (HP:0000176)2.48988456
62Cholelithiasis (HP:0001081)2.48539246
63Torticollis (HP:0000473)2.48486276
64EEG with generalized epileptiform discharges (HP:0011198)2.46505997
65Dysdiadochokinesis (HP:0002075)2.43712039
66Craniofacial dystonia (HP:0012179)2.43008970
67Thoracolumbar scoliosis (HP:0002944)2.41329679
68Scanning speech (HP:0002168)2.41161051
69Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.41142824
70Bradykinesia (HP:0002067)2.40953779
71Postural instability (HP:0002172)2.40813884
72Morphological abnormality of the middle ear (HP:0008609)2.39875634
73Abnormality of the lower motor neuron (HP:0002366)2.37908740
74Limb dystonia (HP:0002451)2.37316352
75Dysmetric saccades (HP:0000641)2.35720331
76Cutaneous syndactyly (HP:0012725)2.30856619
77Chin dimple (HP:0010751)2.30745158
78Mutism (HP:0002300)2.30705208
79Abnormal eating behavior (HP:0100738)2.30212275
80Diminished motivation (HP:0000745)2.30163877
81Failure to thrive in infancy (HP:0001531)2.29531231
82Hypsarrhythmia (HP:0002521)2.28636923
83Sleep apnea (HP:0010535)2.27898751
84Morphological abnormality of the pyramidal tract (HP:0002062)2.27843729
85Postural tremor (HP:0002174)2.27838787
86Broad-based gait (HP:0002136)2.26998440
87Hyperventilation (HP:0002883)2.26261849
88Progressive inability to walk (HP:0002505)2.25628075
89Impaired social interactions (HP:0000735)2.25213101
90Abnormal social behavior (HP:0012433)2.25213101
91Aplasia/Hypoplasia of the brainstem (HP:0007362)2.24693039
92Hypoplasia of the brainstem (HP:0002365)2.24693039
93Ventricular fibrillation (HP:0001663)2.23660247
94Impaired smooth pursuit (HP:0007772)2.23401286
95Stereotypic behavior (HP:0000733)2.23334882
96Spastic gait (HP:0002064)2.22945033
97Abnormal gallbladder morphology (HP:0012437)2.22542896
98Annular pancreas (HP:0001734)2.22263558
99Amyotrophic lateral sclerosis (HP:0007354)2.21708675
100Polyphagia (HP:0002591)2.19614893
101Incomplete penetrance (HP:0003829)2.18220020
102Absent eyelashes (HP:0000561)2.17214334
103Spastic tetraparesis (HP:0001285)2.16585210
104Drooling (HP:0002307)2.13465019
105Abnormality of the corticospinal tract (HP:0002492)2.12462778
106Genetic anticipation (HP:0003743)2.11591274
107Neoplasm of the peripheral nervous system (HP:0100007)2.10336161
108Hammertoe (HP:0001765)2.10253976
109Akinesia (HP:0002304)2.08842934
110Insomnia (HP:0100785)2.08417913
111CNS hypomyelination (HP:0003429)2.05560701
112Fetal akinesia sequence (HP:0001989)2.04274124
113Popliteal pterygium (HP:0009756)2.03684263
114Absent speech (HP:0001344)2.02891761
115Rapidly progressive (HP:0003678)2.02816689
116Myotonia (HP:0002486)2.02090091
117Choreoathetosis (HP:0001266)2.01762919
118Memory impairment (HP:0002354)2.00328784
119Megalencephaly (HP:0001355)2.00175211
120Excessive salivation (HP:0003781)1.99148772
121Abnormality of ocular smooth pursuit (HP:0000617)1.98503279
122Lower limb muscle weakness (HP:0007340)1.97265746
123Reticulocytosis (HP:0001923)1.96397707
124Dysautonomia (HP:0002459)1.95340551
125Hypercortisolism (HP:0001578)1.92912953
126Impaired vibratory sensation (HP:0002495)1.92193690
127Decreased muscle mass (HP:0003199)1.91283203
128Rigidity (HP:0002063)1.91048855
129Bicornuate uterus (HP:0000813)1.90583214
130Hypoventilation (HP:0002791)1.90520354
131Pointed chin (HP:0000307)1.90037949
132Onion bulb formation (HP:0003383)1.89769384
133Resting tremor (HP:0002322)1.88880208
134Gait ataxia (HP:0002066)1.88103879
135Neurofibrillary tangles (HP:0002185)1.86940408
136Abnormality of saccadic eye movements (HP:0000570)1.83268653
137Lower limb asymmetry (HP:0100559)1.79280252
138Spinal canal stenosis (HP:0003416)1.78293136
139Lower limb amyotrophy (HP:0007210)1.76951451
140Dementia (HP:0000726)1.75944171
141Paraplegia (HP:0010550)1.72009523
142Increased circulating renin level (HP:0000848)1.71736589
143Syncope (HP:0001279)1.69172190
144Spastic paraplegia (HP:0001258)1.67869279

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.10117534
2NTRK34.00667183
3EPHA43.57880906
4KSR23.54712054
5DAPK22.89952821
6MINK12.76783244
7MAP3K22.61942005
8MAP3K42.57584732
9RIPK42.40786924
10NTRK12.37168561
11PTK2B2.27828414
12PAK62.22746059
13MARK12.18613057
14MAP2K72.18065541
15GRK52.02229472
16MAP3K121.85842081
17MAP2K41.78170056
18CAMKK11.75799809
19RET1.73896795
20PRKD31.73591649
21LMTK21.59194423
22ARAF1.52815963
23DAPK11.51905787
24CDK51.48418586
25LIMK11.47560211
26LATS21.35728207
27CASK1.34916093
28NTRK21.34765619
29SIK21.27843056
30MAPK131.27142935
31UHMK11.22120716
32RIPK11.21958584
33CAMKK21.19248049
34PLK21.18491134
35MAP3K11.13968205
36PINK11.13669427
37PHKG21.11411812
38PHKG11.11411812
39SGK2231.04582523
40SGK4941.04582523
41FES1.03864273
42DYRK1A1.03248473
43CDK191.02755529
44KSR11.01130239
45STK380.97648881
46CDK140.94791305
47PRKCG0.94479339
48NEK60.93337407
49TLK10.91834887
50SGK20.90746972
51BLK0.90033144
52MAP2K10.86918531
53MAPK120.85647276
54CDK180.85516776
55CDK150.83854149
56TNIK0.83616161
57TAOK10.83264611
58PNCK0.82422154
59MAP3K130.82368076
60CAMK2A0.81946868
61CAMK10.75347073
62SGK30.74487924
63CDK11A0.72559232
64WNK10.69274368
65PRPF4B0.68982897
66TESK10.67615349
67PRKCH0.67551790
68MAPKAPK50.66505469
69PKN10.65369827
70TESK20.64283496
71STK110.63889824
72PAK30.63337680
73PDK10.62029821
74TYRO30.61789836
75PDPK10.58282039
76TNK20.57935812
77OXSR10.57829901
78RPS6KA20.57784913
79RAF10.57296514
80CAMK2B0.56896252
81MAP3K110.54304760
82MARK20.53878156
83FER0.53712375
84CDC42BPA0.52322861
85CAMK1G0.52004085
86ALK0.51807704
87MAP3K70.51658507
88NEK10.48963069
89CSNK1G20.48321953
90CAMK2D0.47014338
91STK390.46334940
92SGK10.46053894
93PRKCZ0.43148859
94DAPK30.43011700
95CAMK40.40058829
96ROCK20.39511051
97CCNB10.38744555
98PRKCE0.38478334
99CAMK1D0.38231784
100FYN0.37569909
101RPS6KA30.37545861
102BMPR20.37019470
103SCYL20.36728134
104CAMK2G0.35636653
105PRKCA0.35324142
106NME10.34617112
107MAPK100.32122388
108PRKG20.31284432
109ROCK10.31239417
110WNK40.30557779
111PRKCB0.29396411
112MAP2K60.28647429
113BRAF0.27729958
114BRSK10.27586643
115MAPK80.27459505
116FGFR20.27149197
117IRAK20.26570388
118CSNK1D0.26053118
119PRKG10.24959519

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.17067455
2Synaptic vesicle cycle_Homo sapiens_hsa047213.39592413
3Nicotine addiction_Homo sapiens_hsa050332.80897382
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.60668867
5Olfactory transduction_Homo sapiens_hsa047402.54180033
6Long-term potentiation_Homo sapiens_hsa047202.35032650
7Circadian entrainment_Homo sapiens_hsa047132.26191868
8Glutamatergic synapse_Homo sapiens_hsa047242.18717621
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15652207
10GABAergic synapse_Homo sapiens_hsa047272.08916248
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.04518803
12Amphetamine addiction_Homo sapiens_hsa050312.02322710
13Morphine addiction_Homo sapiens_hsa050322.01221975
14Insulin secretion_Homo sapiens_hsa049112.00326132
15Salivary secretion_Homo sapiens_hsa049701.99398035
16Dopaminergic synapse_Homo sapiens_hsa047281.93975381
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.92567664
18Taste transduction_Homo sapiens_hsa047421.88371763
19Cholinergic synapse_Homo sapiens_hsa047251.74593423
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.70531495
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64791391
22Type II diabetes mellitus_Homo sapiens_hsa049301.62462083
23Gastric acid secretion_Homo sapiens_hsa049711.62236627
24Collecting duct acid secretion_Homo sapiens_hsa049661.56710665
25Vitamin B6 metabolism_Homo sapiens_hsa007501.55156301
26Carbohydrate digestion and absorption_Homo sapiens_hsa049731.49776962
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49439210
28Long-term depression_Homo sapiens_hsa047301.47194113
29Oxytocin signaling pathway_Homo sapiens_hsa049211.39957592
30Renin secretion_Homo sapiens_hsa049241.35537491
31Serotonergic synapse_Homo sapiens_hsa047261.35307779
32GnRH signaling pathway_Homo sapiens_hsa049121.32358869
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30988685
34Cocaine addiction_Homo sapiens_hsa050301.30850421
35Calcium signaling pathway_Homo sapiens_hsa040201.30455159
36Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.28036389
37Gap junction_Homo sapiens_hsa045401.20814771
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19953271
39Glioma_Homo sapiens_hsa052141.17290934
40Cardiac muscle contraction_Homo sapiens_hsa042601.16051984
41Dorso-ventral axis formation_Homo sapiens_hsa043201.16037316
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08094147
43cAMP signaling pathway_Homo sapiens_hsa040241.04906115
44Estrogen signaling pathway_Homo sapiens_hsa049151.00583460
45ErbB signaling pathway_Homo sapiens_hsa040120.91555772
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91119176
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90150822
48Axon guidance_Homo sapiens_hsa043600.88561077
49Melanogenesis_Homo sapiens_hsa049160.86959016
50Pancreatic secretion_Homo sapiens_hsa049720.86116268
51Vibrio cholerae infection_Homo sapiens_hsa051100.84615630
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.83472088
53Oocyte meiosis_Homo sapiens_hsa041140.80856289
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79648481
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.78843203
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.78182197
57Nitrogen metabolism_Homo sapiens_hsa009100.76889129
58Thyroid hormone synthesis_Homo sapiens_hsa049180.76386020
59VEGF signaling pathway_Homo sapiens_hsa043700.73611699
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.73189007
61Insulin signaling pathway_Homo sapiens_hsa049100.70115721
62Choline metabolism in cancer_Homo sapiens_hsa052310.67186666
63Bile secretion_Homo sapiens_hsa049760.64809429
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61130954
65Endocytosis_Homo sapiens_hsa041440.60082329
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58861578
67MAPK signaling pathway_Homo sapiens_hsa040100.58713298
68Fructose and mannose metabolism_Homo sapiens_hsa000510.58222742
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57903374
70mTOR signaling pathway_Homo sapiens_hsa041500.57166087
71Endometrial cancer_Homo sapiens_hsa052130.56485529
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.54534266
73Rap1 signaling pathway_Homo sapiens_hsa040150.54118283
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53383370
75Phototransduction_Homo sapiens_hsa047440.49358919
76Non-small cell lung cancer_Homo sapiens_hsa052230.48352730
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46588661
78Thyroid cancer_Homo sapiens_hsa052160.46035498
79Ras signaling pathway_Homo sapiens_hsa040140.45506108
80Prion diseases_Homo sapiens_hsa050200.45357257
81Dilated cardiomyopathy_Homo sapiens_hsa054140.45057787
82Inositol phosphate metabolism_Homo sapiens_hsa005620.42325930
83Galactose metabolism_Homo sapiens_hsa000520.41906988
84Glucagon signaling pathway_Homo sapiens_hsa049220.41750316
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40643375
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39394322
87Mineral absorption_Homo sapiens_hsa049780.38157519
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37378420
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37154015
90Alzheimers disease_Homo sapiens_hsa050100.36887046
91Prolactin signaling pathway_Homo sapiens_hsa049170.36547043
92HIF-1 signaling pathway_Homo sapiens_hsa040660.35893536
93Wnt signaling pathway_Homo sapiens_hsa043100.35425914
94Circadian rhythm_Homo sapiens_hsa047100.35011014
95Alcoholism_Homo sapiens_hsa050340.34307338
96Renal cell carcinoma_Homo sapiens_hsa052110.31793248
97Arginine and proline metabolism_Homo sapiens_hsa003300.31762303
98Arginine biosynthesis_Homo sapiens_hsa002200.31489874
99Platelet activation_Homo sapiens_hsa046110.30799414
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29514444
101Salmonella infection_Homo sapiens_hsa051320.29166826
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.29119862
103African trypanosomiasis_Homo sapiens_hsa051430.28601571
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28334343
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28143509
106Ovarian steroidogenesis_Homo sapiens_hsa049130.27471023
107Fatty acid biosynthesis_Homo sapiens_hsa000610.26656704
108Melanoma_Homo sapiens_hsa052180.26330390
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25664822
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25452997
111Tight junction_Homo sapiens_hsa045300.24267942
112Histidine metabolism_Homo sapiens_hsa003400.23964452
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20559438
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18944412
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18483956
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.17192210
117AMPK signaling pathway_Homo sapiens_hsa041520.17031089
118Hippo signaling pathway_Homo sapiens_hsa043900.13956465

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