ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	transcription from mitochondrial promoter (GO:0006390)	8.66443952
2	neuron fate specification (GO:0048665)	8.17709103
3	nuclear pore complex assembly (GO:0051292)	5.86348133
4	neuron maturation (GO:0042551)	5.80038016
5	viral transcription (GO:0019083)	5.27543560
6	positive regulation of gastrulation (GO:2000543)	5.15234696
7	ribosomal small subunit assembly (GO:0000028)	5.03318342
8	translational termination (GO:0006415)	5.01345628
9	ribosomal small subunit biogenesis (GO:0042274)	4.90401805
10	vitamin A metabolic process (GO:0006776)	4.83250259
11	regulation of RNA export from nucleus (GO:0046831)	4.69069795
12	nuclear pore organization (GO:0006999)	4.56032423
13	proline biosynthetic process (GO:0006561)	4.43245366
14	translational elongation (GO:0006414)	4.38654141
15	histone H2B ubiquitination (GO:0033523)	4.37695625
16	G1 DNA damage checkpoint (GO:0044783)	4.24465714
17	regulation of histone H3-K27 methylation (GO:0061085)	4.21752517
18	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.21493059
19	protein targeting to ER (GO:0045047)	4.16943651
20	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.16601021
21	pore complex assembly (GO:0046931)	4.16414498
22	translational initiation (GO:0006413)	4.16263327
23	negative regulation of translational initiation (GO:0045947)	4.15270818
24	cellular zinc ion homeostasis (GO:0006882)	4.15016325
25	cotranslational protein targeting to membrane (GO:0006613)	4.14123260
26	regulation of histone H3-K4 methylation (GO:0051569)	4.13692430
27	ribosomal large subunit biogenesis (GO:0042273)	4.13460181
28	viral life cycle (GO:0019058)	4.04876134
29	cellular protein complex disassembly (GO:0043624)	4.04355860
30	mating behavior (GO:0007617)	4.04254282
31	positive regulation of RNA splicing (GO:0033120)	4.02235170
32	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.98286936
33	protein complex disassembly (GO:0043241)	3.90248311
34	protein localization to endoplasmic reticulum (GO:0070972)	3.83134017
35	mitotic G1/S transition checkpoint (GO:0044819)	3.82401942
36	formation of translation preinitiation complex (GO:0001731)	3.73410908
37	regulation of nucleobase-containing compound transport (GO:0032239)	3.67870735
38	hemidesmosome assembly (GO:0031581)	3.66418058
39	GMP metabolic process (GO:0046037)	3.64906807
40	regulation of translational fidelity (GO:0006450)	3.60238184
41	macromolecular complex disassembly (GO:0032984)	3.57835001
42	primitive streak formation (GO:0090009)	3.54637993
43	positive regulation of vesicle fusion (GO:0031340)	3.51694606
44	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	3.47088297
45	DNA geometric change (GO:0032392)	3.39613191
46	response to vitamin A (GO:0033189)	3.36469236
47	IMP biosynthetic process (GO:0006188)	3.36050674
48	DNA unwinding involved in DNA replication (GO:0006268)	3.35985490
49	DNA replication checkpoint (GO:0000076)	3.34653348
50	DNA replication initiation (GO:0006270)	3.32494544
51	mitochondrial RNA metabolic process (GO:0000959)	3.30351121
52	histone H3-K9 demethylation (GO:0033169)	3.26077046
53	intra-S DNA damage checkpoint (GO:0031573)	3.24811737
54	erythrocyte development (GO:0048821)	3.17244692
55	viral mRNA export from host cell nucleus (GO:0046784)	3.16889528
56	viral protein processing (GO:0019082)	3.14133293
57	ribonucleoprotein complex biogenesis (GO:0022613)	3.13593273
58	zinc ion homeostasis (GO:0055069)	3.12740894
59	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.11533659
60	mitotic chromosome condensation (GO:0007076)	3.06651654
61	zinc ion transmembrane transport (GO:0071577)	3.05409574
62	regulation of receptor binding (GO:1900120)	3.04121242
63	virion assembly (GO:0019068)	3.02693121
64	kinetochore assembly (GO:0051382)	3.02582055
65	spliceosomal tri-snRNP complex assembly (GO:0000244)	3.00070745
66	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	2.99835560
67	mitotic G1 DNA damage checkpoint (GO:0031571)	2.99017245
68	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.98955929
69	DNA conformation change (GO:0071103)	2.98196144
70	mitotic sister chromatid segregation (GO:0000070)	2.95826925
71	maturation of SSU-rRNA (GO:0030490)	2.94245653
72	peristalsis (GO:0030432)	2.91992607
73	kinetochore organization (GO:0051383)	2.91411903
74	glucosamine-containing compound catabolic process (GO:1901072)	2.90979578
75	regulation of water loss via skin (GO:0033561)	2.90403785
76	definitive hemopoiesis (GO:0060216)	2.86827730
77	mRNA catabolic process (GO:0006402)	2.86567079
78	RNA destabilization (GO:0050779)	2.85679209
79	protein targeting to membrane (GO:0006612)	2.85127563
80	regulation of histone methylation (GO:0031060)	2.82311079
81	termination of RNA polymerase I transcription (GO:0006363)	2.81110663
82	RNA stabilization (GO:0043489)	2.79213587
83	mRNA stabilization (GO:0048255)	2.79213587
84	protein-DNA complex disassembly (GO:0032986)	2.76341089
85	nucleosome disassembly (GO:0006337)	2.76341089
86	biotin metabolic process (GO:0006768)	2.75454906
87	DNA-templated transcription, termination (GO:0006353)	2.73492717
88	peripheral nervous system neuron development (GO:0048935)	2.72216174
89	sister chromatid segregation (GO:0000819)	2.70890923
90	erythrocyte maturation (GO:0043249)	2.68895052
91	proline metabolic process (GO:0006560)	2.65859166
92	regulation of mitotic spindle organization (GO:0060236)	2.65011330
93	seminiferous tubule development (GO:0072520)	2.62891536
94	norepinephrine metabolic process (GO:0042415)	2.62710250
95	cell fate specification (GO:0001708)	2.61780505
96	positive regulation of megakaryocyte differentiation (GO:0045654)	2.60780277
97	positive regulation of histone deacetylation (GO:0031065)	2.58820205
98	DNA topological change (GO:0006265)	2.57681666
99	IMP metabolic process (GO:0046040)	2.57150656
100	RNA localization (GO:0006403)	2.55769216

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.46661981
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	5.17566245
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.74411334
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.70076983
5	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.61417404
6	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.58984802
7	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.28675687
8	XRN2_22483619_ChIP-Seq_HELA_Human	2.65087314
9	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.63287608
10	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.55212547
11	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.47065220
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.37427498
13	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.33909365
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.27159840
15	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.27021639
16	KDM5A_27292631_Chip-Seq_BREAST_Human	2.24368478
17	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	2.22392808
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.21492852
19	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.10976601
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.01689895
21	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.97990423
22	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.94557017
23	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.91565906
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.90006862
25	NCOR1_26117541_ChIP-Seq_K562_Human	1.87634400
26	GATA1_19941826_ChIP-Seq_K562_Human	1.87414837
27	AR_21909140_ChIP-Seq_LNCAP_Human	1.84769114
28	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.80744540
29	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.80605813
30	TTF2_22483619_ChIP-Seq_HELA_Human	1.68137192
31	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.65772789
32	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.63830488
33	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.62583895
34	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.60147168
35	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.59737706
36	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.53247407
37	DCP1A_22483619_ChIP-Seq_HELA_Human	1.52083961
38	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.51366577
39	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.50351752
40	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.46912490
41	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.43208345
42	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.43064735
43	GATA2_19941826_ChIP-Seq_K562_Human	1.40991355
44	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.40412535
45	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.39973521
46	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.37529026
47	CHD1_26751641_Chip-Seq_LNCaP_Human	1.37325244
48	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.36019021
49	RACK7_27058665_Chip-Seq_MCF-7_Human	1.34804078
50	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.32578795
51	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.32440331
52	ELK1_19687146_ChIP-ChIP_HELA_Human	1.32262196
53	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.31450368
54	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.30743346
55	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.29666595
56	CREB1_26743006_Chip-Seq_LNCaP_Human	1.29211312
57	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.25932939
58	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.24905427
59	SMC4_20622854_ChIP-Seq_HELA_Human	1.23494339
60	MYC_22102868_ChIP-Seq_BL_Human	1.21985810
61	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.21409962
62	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.21062132
63	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.20813401
64	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.19475956
65	GATA6_25053715_ChIP-Seq_YYC3_Human	1.16183061
66	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.15497319
67	ZNF263_19887448_ChIP-Seq_K562_Human	1.12218339
68	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.11576396
69	P68_20966046_ChIP-Seq_HELA_Human	1.10032119
70	ATF3_27146783_Chip-Seq_COLON_Human	1.07091910
71	GABP_19822575_ChIP-Seq_HepG2_Human	1.06291088
72	E2F1_20622854_ChIP-Seq_HELA_Human	1.05224872
73	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.04085818
74	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.01269055
75	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.00935748
76	AR_21572438_ChIP-Seq_LNCaP_Human	0.99995759
77	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.98996076
78	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.98936974
79	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.98027110
80	FOXP3_21729870_ChIP-Seq_TREG_Human	0.98022263
81	PHF8_20622854_ChIP-Seq_HELA_Human	0.97144433
82	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.95874036
83	IRF1_19129219_ChIP-ChIP_H3396_Human	0.95793956
84	VDR_23849224_ChIP-Seq_CD4+_Human	0.94827038
85	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.93673105
86	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.92169654
87	MYC_18940864_ChIP-ChIP_HL60_Human	0.90896744
88	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.90392595
89	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.89897012
90	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.89674714
91	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.89674714
92	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.89674714
93	GATA1_22025678_ChIP-Seq_K562_Human	0.89635856
94	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.88827686
95	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.88185289
96	LXR_22292898_ChIP-Seq_THP-1_Human	0.88039086
97	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.87659249
98	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.87628711
99	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.86958450
100	VDR_22108803_ChIP-Seq_LS180_Human	0.85416409

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008995_early_reproductive_senescence	4.74099246
2	MP0002009_preneoplasia	3.46793266
3	MP0005503_abnormal_tendon_morphology	3.24187973
4	MP0005171_absent_coat_pigmentation	2.94382386
5	MP0000566_synostosis	2.80869753
6	MP0003693_abnormal_embryo_hatching	2.78726360
7	MP0005451_abnormal_body_composition	2.38715497
8	MP0001293_anophthalmia	2.38322308
9	MP0004264_abnormal_extraembryonic_tissu	2.29543304
10	MP0002796_impaired_skin_barrier	2.29381592
11	MP0003718_maternal_effect	2.26577621
12	MP0005501_abnormal_skin_physiology	2.23244688
13	MP0003786_premature_aging	2.12340995
14	MP0004185_abnormal_adipocyte_glucose	2.12056790
15	MP0008007_abnormal_cellular_replicative	2.07756199
16	MP0003942_abnormal_urinary_system	2.02466261
17	MP0003890_abnormal_embryonic-extraembry	1.95373348
18	MP0010094_abnormal_chromosome_stability	1.92477032
19	MP0005646_abnormal_pituitary_gland	1.89872644
20	MP0003077_abnormal_cell_cycle	1.82013027
21	MP0010307_abnormal_tumor_latency	1.77058294
22	MP0003315_abnormal_perineum_morphology	1.76227225
23	MP0009379_abnormal_foot_pigmentation	1.75568468
24	MP0000383_abnormal_hair_follicle	1.74383541
25	MP0000678_abnormal_parathyroid_gland	1.73995454
26	MP0009053_abnormal_anal_canal	1.73183718
27	MP0000647_abnormal_sebaceous_gland	1.68703015
28	MP0000534_abnormal_ureter_morphology	1.68058857
29	MP0002938_white_spotting	1.60846658
30	MP0002184_abnormal_innervation	1.59966922
31	MP0009780_abnormal_chondrocyte_physiolo	1.56027791
32	MP0006035_abnormal_mitochondrial_morpho	1.55599798
33	MP0003111_abnormal_nucleus_morphology	1.50707817
34	MP0004957_abnormal_blastocyst_morpholog	1.46336038
35	MP0002928_abnormal_bile_duct	1.44606451
36	MP0002163_abnormal_gland_morphology	1.42914021
37	MP0005174_abnormal_tail_pigmentation	1.40742860
38	MP0005408_hypopigmentation	1.40332058
39	MP0000569_abnormal_digit_pigmentation	1.32121469
40	MP0000350_abnormal_cell_proliferation	1.28564586
41	MP0001730_embryonic_growth_arrest	1.27140437
42	MP0002095_abnormal_skin_pigmentation	1.26049975
43	MP0003943_abnormal_hepatobiliary_system	1.25358237
44	MP0002557_abnormal_social/conspecific_i	1.25338760
45	MP0004133_heterotaxia	1.22880816
46	MP0002877_abnormal_melanocyte_morpholog	1.17763454
47	MP0008058_abnormal_DNA_repair	1.16824943
48	MP0008932_abnormal_embryonic_tissue	1.16047149
49	MP0010678_abnormal_skin_adnexa	1.14621104
50	MP0000377_abnormal_hair_follicle	1.13747045
51	MP0002822_catalepsy	1.11217236
52	MP0003705_abnormal_hypodermis_morpholog	1.10998717
53	MP0008961_abnormal_basal_metabolism	1.10723599
54	MP0000579_abnormal_nail_morphology	1.10494586
55	MP0002108_abnormal_muscle_morphology	1.09386824
56	MP0002269_muscular_atrophy	1.09375205
57	MP0002249_abnormal_larynx_morphology	1.07435891
58	MP0003656_abnormal_erythrocyte_physiolo	1.07422352
59	MP0003937_abnormal_limbs/digits/tail_de	1.05234674
60	MP0004782_abnormal_surfactant_physiolog	1.04950072
61	MP0000749_muscle_degeneration	1.04400003
62	MP0005187_abnormal_penis_morphology	1.03885652
63	MP0005076_abnormal_cell_differentiation	0.98901671
64	MP0002080_prenatal_lethality	0.97176470
65	MP0001727_abnormal_embryo_implantation	0.97141581
66	MP0005380_embryogenesis_phenotype	0.95361979
67	MP0001672_abnormal_embryogenesis/_devel	0.95361979
68	MP0004381_abnormal_hair_follicle	0.94768260
69	MP0002092_abnormal_eye_morphology	0.94030503
70	MP0005666_abnormal_adipose_tissue	0.93998657
71	MP0001944_abnormal_pancreas_morphology	0.92979924
72	MP0004233_abnormal_muscle_weight	0.92664247
73	MP0003959_abnormal_lean_body	0.92462696
74	MP0003984_embryonic_growth_retardation	0.90889286
75	MP0002084_abnormal_developmental_patter	0.89821341
76	MP0004858_abnormal_nervous_system	0.88948898
77	MP0002088_abnormal_embryonic_growth/wei	0.88265273
78	MP0010352_gastrointestinal_tract_polyps	0.87809486
79	MP0005083_abnormal_biliary_tract	0.86694070
80	MP0003115_abnormal_respiratory_system	0.84776805
81	MP0000003_abnormal_adipose_tissue	0.84548177
82	MP0010771_integument_phenotype	0.82459434
83	MP0001873_stomach_inflammation	0.78368561
84	MP0000516_abnormal_urinary_system	0.78364643
85	MP0005367_renal/urinary_system_phenotyp	0.78364643
86	MP0002085_abnormal_embryonic_tissue	0.78320321
87	MP0009697_abnormal_copulation	0.77326976
88	MP0002210_abnormal_sex_determination	0.77150495
89	MP0001929_abnormal_gametogenesis	0.75082284
90	MP0000313_abnormal_cell_death	0.74232033
91	MP0005508_abnormal_skeleton_morphology	0.73712196
92	MP0001697_abnormal_embryo_size	0.72683638
93	MP0003698_abnormal_male_reproductive	0.71300095
94	MP0004197_abnormal_fetal_growth/weight/	0.70287020
95	MP0001529_abnormal_vocalization	0.70130364
96	MP0000372_irregular_coat_pigmentation	0.68583484
97	MP0003011_delayed_dark_adaptation	0.68548461
98	MP0004134_abnormal_chest_morphology	0.67844501
99	MP0005395_other_phenotype	0.66767089
100	MP0000751_myopathy	0.66737727

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Urethral obstruction (HP:0000796)	6.92452459
2	Alopecia of scalp (HP:0002293)	6.65202128
3	Cholecystitis (HP:0001082)	5.01951177
4	Abnormal gallbladder physiology (HP:0012438)	5.01951177
5	Attenuation of retinal blood vessels (HP:0007843)	4.97807314
6	Partial duplication of thumb phalanx (HP:0009944)	4.84548300
7	Bony spicule pigmentary retinopathy (HP:0007737)	4.66772820
8	Partial duplication of the phalanx of hand (HP:0009999)	4.17186570
9	Microvesicular hepatic steatosis (HP:0001414)	3.69613953
10	Duplication of thumb phalanx (HP:0009942)	3.46042167
11	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	3.43476791
12	Concave nail (HP:0001598)	3.40152527
13	Pheochromocytoma (HP:0002666)	3.28818917
14	Abolished electroretinogram (ERG) (HP:0000550)	3.23703928
15	Birth length less than 3rd percentile (HP:0003561)	3.20105621
16	Abnormal hemoglobin (HP:0011902)	3.06622538
17	Reticulocytosis (HP:0001923)	3.01753374
18	Oligodactyly (hands) (HP:0001180)	3.00590791
19	Cortical visual impairment (HP:0100704)	3.00314625
20	Pustule (HP:0200039)	2.98090804
21	Split foot (HP:0001839)	2.84956044
22	Pallor (HP:0000980)	2.79370218
23	Ileus (HP:0002595)	2.77888918
24	Increased connective tissue (HP:0009025)	2.77555038
25	Abnormality of reticulocytes (HP:0004312)	2.67681049
26	Polycythemia (HP:0001901)	2.67129915
27	Seborrheic dermatitis (HP:0001051)	2.66112802
28	Neuroendocrine neoplasm (HP:0100634)	2.63184679
29	Patellar aplasia (HP:0006443)	2.62450465
30	Clumsiness (HP:0002312)	2.60938098
31	Alacrima (HP:0000522)	2.59556464
32	Peripheral hypomyelination (HP:0007182)	2.59145094
33	Homocystinuria (HP:0002156)	2.58436632
34	Abnormality of homocysteine metabolism (HP:0010919)	2.58436632
35	Morphological abnormality of the inner ear (HP:0011390)	2.57911642
36	3-Methylglutaconic aciduria (HP:0003535)	2.57842482
37	Abnormality of the salivary glands (HP:0010286)	2.50606741
38	Difficulty climbing stairs (HP:0003551)	2.48998824
39	Myopathic facies (HP:0002058)	2.48909913
40	Macrocytic anemia (HP:0001972)	2.43067774
41	Abnormally folded helix (HP:0008544)	2.38280122
42	Aplasia/Hypoplasia of the patella (HP:0006498)	2.37994601
43	Sparse lateral eyebrow (HP:0005338)	2.35043772
44	Hyperthyroidism (HP:0000836)	2.33423383
45	Acute hepatic failure (HP:0006554)	2.31885452
46	Ragged-red muscle fibers (HP:0003200)	2.26882200
47	Hypoplasia of the pons (HP:0012110)	2.24216126
48	Cholelithiasis (HP:0001081)	2.23558601
49	Limited elbow extension (HP:0001377)	2.20870240
50	Chronic hepatic failure (HP:0100626)	2.18329527
51	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.17846452
52	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.17846452
53	Bowel incontinence (HP:0002607)	2.15554562
54	Hypertensive crisis (HP:0100735)	2.13010012
55	Oligodactyly (HP:0012165)	2.12621766
56	Underdeveloped nasal alae (HP:0000430)	2.08059489
57	Calcaneovalgus deformity (HP:0001848)	2.07036073
58	Patellar dislocation (HP:0002999)	2.05025432
59	Truncus arteriosus (HP:0001660)	2.02313504
60	Macular degeneration (HP:0000608)	2.01869540
61	Breast hypoplasia (HP:0003187)	2.01221074
62	Diaphragmatic weakness (HP:0009113)	1.99787547
63	Sandal gap (HP:0001852)	1.98717185
64	Squamous cell carcinoma (HP:0002860)	1.98537969
65	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.97950157
66	Hand muscle atrophy (HP:0009130)	1.97656102
67	Optic disc pallor (HP:0000543)	1.96916518
68	Hypoparathyroidism (HP:0000829)	1.96854582
69	Cutaneous melanoma (HP:0012056)	1.96403370
70	Reticulocytopenia (HP:0001896)	1.95750586
71	Abnormality of the pons (HP:0007361)	1.93748928
72	Abnormal large intestine physiology (HP:0012700)	1.92808454
73	Aplastic anemia (HP:0001915)	1.89191842
74	Increased intramyocellular lipid droplets (HP:0012240)	1.88576722
75	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.87195336
76	Long toe (HP:0010511)	1.86731211
77	Bifid scrotum (HP:0000048)	1.86582607
78	Decreased lacrimation (HP:0000633)	1.85918625
79	Abnormal gallbladder morphology (HP:0012437)	1.85616897
80	Abnormality of the calcaneus (HP:0008364)	1.84665370
81	Flat occiput (HP:0005469)	1.84381694
82	Abnormality of the vocal cords (HP:0008777)	1.83988245
83	Self-mutilation (HP:0000742)	1.81812872
84	Fatigable weakness (HP:0003473)	1.81619238
85	Abnormality of the neuromuscular junction (HP:0003398)	1.81619238
86	Neonatal respiratory distress (HP:0002643)	1.80219301
87	Neoplasm of the peripheral nervous system (HP:0100007)	1.79880827
88	Short ribs (HP:0000773)	1.76129460
89	Ectopic anus (HP:0004397)	1.75822706
90	Thick nail (HP:0001805)	1.75292401
91	Fatigue (HP:0012378)	1.74341960
92	Ependymoma (HP:0002888)	1.74026999
93	Aplasia of the musculature (HP:0100854)	1.72872366
94	Distal upper limb amyotrophy (HP:0007149)	1.72779255
95	Upper limb amyotrophy (HP:0009129)	1.72779255
96	Overfolded helix (HP:0000396)	1.72234837
97	Abnormality of the epiphyses of the hand (HP:0005924)	1.71089847
98	Morphological abnormality of the middle ear (HP:0008609)	1.70713291
99	Abnormality of cells of the erythroid lineage (HP:0012130)	1.70300500
100	Abnormality of chromosome segregation (HP:0002916)	1.70274032

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK8	4.48085560
2	TRIB3	3.98639160
3	NEK1	3.87155401
4	PBK	2.99725560
5	RPS6KB2	2.90329807
6	EIF2AK1	2.76001481
7	CDK12	2.69358498
8	ICK	2.46248464
9	MAP3K6	2.45903898
10	CHEK2	2.22210903
11	EEF2K	2.19023061
12	CDK7	2.05799935
13	NME2	1.94942389
14	CDC7	1.93296186
15	PKN2	1.90088960
16	BUB1	1.89396304
17	TAF1	1.79685129
18	SCYL2	1.79254136
19	MAP3K12	1.71927435
20	PASK	1.64321567
21	TSSK6	1.57615347
22	RIPK4	1.54475695
23	BRSK2	1.50702716
24	MAP2K3	1.49233934
25	NEK6	1.49149364
26	BMPR2	1.42341248
27	PRKD3	1.40860254
28	IRAK3	1.39924096
29	PAK2	1.38865157
30	KSR2	1.36563808
31	RET	1.28827324
32	PLK4	1.26907205
33	SMG1	1.22453761
34	EIF2AK3	1.19148517
35	BRSK1	1.11017083
36	MAPKAPK3	1.08478793
37	TTK	1.08164147
38	MTOR	1.08034947
39	CAMK1D	1.04016544
40	DMPK	1.02978060
41	AKT3	0.97950516
42	FGFR3	0.97885566
43	MAP3K5	0.95854412
44	DYRK3	0.95740168
45	MAP2K4	0.95030525
46	EPHA2	0.94039448
47	NME1	0.90607130
48	NTRK3	0.89946684
49	WEE1	0.86959440
50	AURKB	0.84650713
51	STK10	0.83922185
52	ILK	0.82791892
53	MAP3K2	0.80176255
54	ATR	0.79051549
55	SIK1	0.77147704
56	YES1	0.71103010
57	CLK1	0.67301732
58	DYRK1B	0.62864925
59	RPS6KB1	0.62766239
60	MKNK1	0.61829886
61	KSR1	0.61828340
62	ADRBK1	0.61809200
63	FGFR1	0.61065987
64	LRRK2	0.60584379
65	CSNK1E	0.59289497
66	MAP2K6	0.58620835
67	CDK1	0.58012537
68	ALK	0.57328395
69	RPS6KL1	0.56197412
70	RPS6KC1	0.56197412
71	MATK	0.55952459
72	MAP3K8	0.54548402
73	CHEK1	0.54436336
74	TAOK3	0.54326949
75	MARK3	0.53816312
76	ATM	0.51593274
77	MAPK14	0.51493301
78	SRPK1	0.50256618
79	CSNK2A2	0.49502301
80	PAK4	0.49468661
81	PIK3CA	0.49413462
82	RPS6KA6	0.49356283
83	RAF1	0.49072734
84	MAPKAPK5	0.47156265
85	CDK2	0.46240179
86	TTN	0.46102953
87	ZAP70	0.45124932
88	RPS6KA2	0.44337104
89	CAMK1G	0.42353093
90	STK38	0.41851296
91	CCNB1	0.40386121
92	AURKA	0.38125527
93	AKT2	0.37670784
94	CHUK	0.37272972
95	MKNK2	0.37002422
96	PTK2B	0.34944230
97	PDPK1	0.33645408
98	GSK3B	0.32797942
99	TNK2	0.32396217
100	EIF2AK2	0.30196137

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.48929844
2	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	3.43057001
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.08214536
4	RNA transport_Homo sapiens_hsa03013	2.88271343
5	RNA polymerase_Homo sapiens_hsa03020	2.83051934
6	One carbon pool by folate_Homo sapiens_hsa00670	2.54842938
7	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.51909061
8	Spliceosome_Homo sapiens_hsa03040	2.27151844
9	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.12897928
10	Mismatch repair_Homo sapiens_hsa03430	2.02295267
11	mRNA surveillance pathway_Homo sapiens_hsa03015	1.90385140
12	Bladder cancer_Homo sapiens_hsa05219	1.85035728
13	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.78720275
14	Acute myeloid leukemia_Homo sapiens_hsa05221	1.76282001
15	DNA replication_Homo sapiens_hsa03030	1.65647055
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.60305437
17	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.54181944
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.52146853
19	Non-small cell lung cancer_Homo sapiens_hsa05223	1.49622576
20	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.49467490
21	Glutathione metabolism_Homo sapiens_hsa00480	1.49015870
22	mTOR signaling pathway_Homo sapiens_hsa04150	1.46740752
23	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.39063202
24	Thyroid cancer_Homo sapiens_hsa05216	1.38764176
25	Cell cycle_Homo sapiens_hsa04110	1.38472327
26	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.37050595
27	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.34490613
28	VEGF signaling pathway_Homo sapiens_hsa04370	1.27715360
29	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.25288720
30	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.20847139
31	Homologous recombination_Homo sapiens_hsa03440	1.19179217
32	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.17387251
33	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.16881459
34	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.16415391
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.15888175
36	RNA degradation_Homo sapiens_hsa03018	1.12509410
37	MicroRNAs in cancer_Homo sapiens_hsa05206	1.12202712
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.10402235
39	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.07902474
40	Basal transcription factors_Homo sapiens_hsa03022	1.01714505
41	Protein export_Homo sapiens_hsa03060	0.99898917
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.98455933
43	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.97088050
44	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.96995997
45	Linoleic acid metabolism_Homo sapiens_hsa00591	0.93110726
46	Olfactory transduction_Homo sapiens_hsa04740	0.92357993
47	Insulin signaling pathway_Homo sapiens_hsa04910	0.85942577
48	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.84980292
49	Purine metabolism_Homo sapiens_hsa00230	0.83729494
50	Pancreatic cancer_Homo sapiens_hsa05212	0.83700234
51	Pyruvate metabolism_Homo sapiens_hsa00620	0.83168703
52	Mineral absorption_Homo sapiens_hsa04978	0.82887215
53	Other glycan degradation_Homo sapiens_hsa00511	0.81521567
54	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.78619180
55	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.78368129
56	ErbB signaling pathway_Homo sapiens_hsa04012	0.78186466
57	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.78167350
58	Choline metabolism in cancer_Homo sapiens_hsa05231	0.77740533
59	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.77651845
60	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.77167105
61	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.76875636
62	Small cell lung cancer_Homo sapiens_hsa05222	0.73643677
63	Renal cell carcinoma_Homo sapiens_hsa05211	0.73572208
64	Carbon metabolism_Homo sapiens_hsa01200	0.71884465
65	Prostate cancer_Homo sapiens_hsa05215	0.70600798
66	Glioma_Homo sapiens_hsa05214	0.69761945
67	Regulation of autophagy_Homo sapiens_hsa04140	0.69665902
68	Type II diabetes mellitus_Homo sapiens_hsa04930	0.68095790
69	Base excision repair_Homo sapiens_hsa03410	0.64457914
70	Selenocompound metabolism_Homo sapiens_hsa00450	0.63270026
71	Amphetamine addiction_Homo sapiens_hsa05031	0.59635492
72	Caffeine metabolism_Homo sapiens_hsa00232	0.58757890
73	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.58317793
74	Cocaine addiction_Homo sapiens_hsa05030	0.57201228
75	Endometrial cancer_Homo sapiens_hsa05213	0.54735939
76	Alcoholism_Homo sapiens_hsa05034	0.53177064
77	Lysine degradation_Homo sapiens_hsa00310	0.52329387
78	Viral carcinogenesis_Homo sapiens_hsa05203	0.51771508
79	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.51440130
80	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.51169341
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49903229
82	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.49103752
83	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.48811967
84	Prolactin signaling pathway_Homo sapiens_hsa04917	0.47963051
85	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.45799162
86	Melanoma_Homo sapiens_hsa05218	0.45191412
87	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.44838452
88	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.44465869
89	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.41010806
90	Prion diseases_Homo sapiens_hsa05020	0.40823514
91	Oocyte meiosis_Homo sapiens_hsa04114	0.40813670
92	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.39053253
93	Taste transduction_Homo sapiens_hsa04742	0.38301661
94	Estrogen signaling pathway_Homo sapiens_hsa04915	0.35144326
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33572787
96	Tyrosine metabolism_Homo sapiens_hsa00350	0.30888541
97	FoxO signaling pathway_Homo sapiens_hsa04068	0.30693134
98	Pentose phosphate pathway_Homo sapiens_hsa00030	0.30415150
99	Huntingtons disease_Homo sapiens_hsa05016	0.28389059
100	Proteasome_Homo sapiens_hsa03050	0.27587821

PHF2P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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