PHF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a PHD finger-containing gene family. This gene may function as a transcription factor and may be involved in glioblastomas development. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.15260827
2nuclear pore organization (GO:0006999)5.65718020
3mitotic sister chromatid cohesion (GO:0007064)5.57659433
4pre-miRNA processing (GO:0031054)5.15992181
5regulation of Wnt signaling pathway involved in heart development (GO:0003307)5.15883079
6phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)5.02131343
7interkinetic nuclear migration (GO:0022027)4.84140633
8regulation of RNA export from nucleus (GO:0046831)4.54168262
9negative regulation of histone methylation (GO:0031061)4.53016722
10pore complex assembly (GO:0046931)4.52336822
11secondary heart field specification (GO:0003139)4.47148857
12heart field specification (GO:0003128)4.47148857
13cytoplasmic mRNA processing body assembly (GO:0033962)4.34499218
14growth hormone receptor signaling pathway (GO:0060396)4.32480029
15regulation of sister chromatid cohesion (GO:0007063)4.13833159
16mitotic chromosome condensation (GO:0007076)4.07729805
17histone H2A monoubiquitination (GO:0035518)4.07101062
18cellular response to growth hormone stimulus (GO:0071378)4.04115160
19positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.02246664
20positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.02246664
21positive regulation of mitotic sister chromatid separation (GO:1901970)4.02246664
22establishment of protein localization to Golgi (GO:0072600)3.90535742
23regulation of histone H3-K9 methylation (GO:0051570)3.83447152
24positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.72489177
25regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.72489177
26monoubiquitinated protein deubiquitination (GO:0035520)3.71096420
27regulation of nucleobase-containing compound transport (GO:0032239)3.69721380
28positive regulation of fibroblast migration (GO:0010763)3.67278259
29sister chromatid segregation (GO:0000819)3.64266529
30cellular anion homeostasis (GO:0030002)3.59642867
31protein targeting to Golgi (GO:0000042)3.58600211
32regulation of mitotic spindle organization (GO:0060236)3.56408969
33positive regulation of chromosome segregation (GO:0051984)3.51378861
34regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.47062334
35glucocorticoid receptor signaling pathway (GO:0042921)3.46618511
36positive regulation of mRNA 3-end processing (GO:0031442)3.46291469
37negative regulation of cell fate specification (GO:0009996)3.46080082
38necroptotic process (GO:0070266)3.45601770
39mitotic nuclear envelope disassembly (GO:0007077)3.44899734
40retrograde transport, vesicle recycling within Golgi (GO:0000301)3.43232941
41chromatin assembly (GO:0031497)3.42961412
42regulation of spindle organization (GO:0090224)3.42786661
43protein localization to kinetochore (GO:0034501)3.42461185
44heterochromatin organization (GO:0070828)3.40349057
45somite rostral/caudal axis specification (GO:0032525)3.34447337
46membrane disassembly (GO:0030397)3.33105956
47nuclear envelope disassembly (GO:0051081)3.33105956
48mitotic sister chromatid segregation (GO:0000070)3.32993478
49NLS-bearing protein import into nucleus (GO:0006607)3.31590068
50dosage compensation (GO:0007549)3.30329535
51intra-S DNA damage checkpoint (GO:0031573)3.30174237
52nucleus localization (GO:0051647)3.26991617
53mitotic metaphase plate congression (GO:0007080)3.25123772
54regulation of mRNA 3-end processing (GO:0031440)3.24554300
55histone H3-K4 methylation (GO:0051568)3.23815884
56regulation of gene silencing by miRNA (GO:0060964)3.22539991
57regulation of gene silencing by RNA (GO:0060966)3.22539991
58regulation of posttranscriptional gene silencing (GO:0060147)3.22539991
59positive regulation of endothelial cell apoptotic process (GO:2000353)3.21637912
60DNA duplex unwinding (GO:0032508)3.20923203
61paraxial mesoderm development (GO:0048339)3.20418683
62DNA geometric change (GO:0032392)3.19776975
63regulation of hippo signaling (GO:0035330)3.17551598
64corticosteroid receptor signaling pathway (GO:0031958)3.17280722
65mRNA stabilization (GO:0048255)3.16332194
66RNA stabilization (GO:0043489)3.16332194
67gene silencing by RNA (GO:0031047)3.15657283
68peptidyl-threonine dephosphorylation (GO:0035970)3.13929368
69positive regulation of mRNA catabolic process (GO:0061014)3.13022415
70cardiac ventricle formation (GO:0003211)3.09736530
71sister chromatid cohesion (GO:0007062)3.08495476
72protein K48-linked deubiquitination (GO:0071108)3.06804084
73metaphase plate congression (GO:0051310)3.06417820
74histone lysine demethylation (GO:0070076)3.05107874
75specification of organ identity (GO:0010092)3.04425749
76histone H3-K9 methylation (GO:0051567)3.04365643
77regulation of establishment of cell polarity (GO:2000114)3.04104572
78protein localization to chromosome, centromeric region (GO:0071459)3.02474386
79cell migration involved in gastrulation (GO:0042074)3.02107018
80microtubule anchoring (GO:0034453)3.00885872
81nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.00671314
82snRNA transcription (GO:0009301)2.98725806
83histone H4-K12 acetylation (GO:0043983)2.98062079
84histone H3-K36 demethylation (GO:0070544)2.97433051
85negative regulation of histone modification (GO:0031057)2.96265375
86cardiac chamber formation (GO:0003207)2.95926411
87positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.95896339
88histone H3-K4 trimethylation (GO:0080182)2.95771473
89regulation of DNA endoreduplication (GO:0032875)2.93316314
90regulation of protein polyubiquitination (GO:1902914)2.92984847
91genitalia morphogenesis (GO:0035112)2.92149652
92phosphatidylinositol phosphorylation (GO:0046854)2.91713437
93kinetochore organization (GO:0051383)2.91256253
94positive regulation of mRNA processing (GO:0050685)2.90820258
95histone demethylation (GO:0016577)2.90182325
96negative regulation of DNA repair (GO:0045738)2.89323690
97negative regulation of translation, ncRNA-mediated (GO:0040033)2.87996376
98regulation of translation, ncRNA-mediated (GO:0045974)2.87996376
99negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.87996376
100gene silencing (GO:0016458)2.87812240
101regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.87793987
102histone H3-K9 demethylation (GO:0033169)2.87358498
103cellular response to ethanol (GO:0071361)2.86644575
104negative regulation of chromatin modification (GO:1903309)2.86174441
105necrotic cell death (GO:0070265)2.85562862
106peptidyl-lysine trimethylation (GO:0018023)2.84165041
107trophectodermal cell differentiation (GO:0001829)2.83684809
108histone H3-K9 modification (GO:0061647)2.83177557
109regulation of mRNA catabolic process (GO:0061013)2.82238864
110DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.82223678
111peptidyl-lysine methylation (GO:0018022)2.81063367
112protein K11-linked deubiquitination (GO:0035871)2.80756547
113response to UV-C (GO:0010225)2.80468656
114insulin-like growth factor receptor signaling pathway (GO:0048009)2.80232846
115regulation of histone H3-K27 methylation (GO:0061085)2.79521293
116histone mRNA catabolic process (GO:0071044)2.79057908
117histone lysine methylation (GO:0034968)2.79038455
118chromatin assembly or disassembly (GO:0006333)2.78944028
119nucleus organization (GO:0006997)2.77549893
120positive regulation of SMAD protein import into nucleus (GO:0060391)2.77469506
121definitive hemopoiesis (GO:0060216)2.76945207
122positive regulation of DNA-templated transcription, initiation (GO:2000144)2.76124221
123intestinal epithelial cell development (GO:0060576)2.73863933
124positive regulation of developmental pigmentation (GO:0048087)2.73147993
125N-terminal protein amino acid acetylation (GO:0006474)2.72601661
126nuclear envelope organization (GO:0006998)2.70290834
127regulation of translational fidelity (GO:0006450)2.69973379
128histone H4-K16 acetylation (GO:0043984)2.69439153
129embryonic process involved in female pregnancy (GO:0060136)2.69270909
130hippo signaling (GO:0035329)2.69163558
131regulation of histone methylation (GO:0031060)2.68984149
132establishment of chromosome localization (GO:0051303)2.67938213
133regulation of centriole replication (GO:0046599)2.66717272
134positive regulation of gene expression, epigenetic (GO:0045815)2.66583500
135histone-serine phosphorylation (GO:0035404)2.65354724
136DNA conformation change (GO:0071103)2.62620245
137positive regulation of histone deacetylation (GO:0031065)2.61953910
138histone H2A ubiquitination (GO:0033522)2.61231528
139regulation of centrosome cycle (GO:0046605)2.60910755
140embryonic retina morphogenesis in camera-type eye (GO:0060059)2.60874915
141regulation of mesoderm development (GO:2000380)2.60830360
142protein localization to chromosome (GO:0034502)2.60818193
143histone monoubiquitination (GO:0010390)2.58661774
144establishment of nucleus localization (GO:0040023)2.57824847
145spindle assembly involved in mitosis (GO:0090307)2.56608491
146protein demethylation (GO:0006482)2.56438055
147protein dealkylation (GO:0008214)2.56438055
148regulation of pigment cell differentiation (GO:0050932)2.56123887
149regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.55457228
150positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.55457228
151regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.54978807
152regulation of gene silencing (GO:0060968)2.54497237
153neural tube formation (GO:0001841)2.53448622
154programmed necrotic cell death (GO:0097300)2.53150039
155determination of adult lifespan (GO:0008340)2.52809485
156positive regulation of mRNA metabolic process (GO:1903313)2.52688946
157intra-Golgi vesicle-mediated transport (GO:0006891)2.51374932
158regulation of establishment or maintenance of cell polarity (GO:0032878)2.49394842
159lipid translocation (GO:0034204)2.47081970
160phospholipid translocation (GO:0045332)2.47081970
161cell migration involved in heart development (GO:0060973)2.45056775

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.40904381
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.56995645
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.20721149
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.07524408
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.38391930
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.33560708
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.13719579
8* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.65158630
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.61429298
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58052777
11MYC_22102868_ChIP-Seq_BL_Human2.56165611
12SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.35481859
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.29910387
14FUS_26573619_Chip-Seq_HEK293_Human2.18987914
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.16726980
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11316701
17AR_21909140_ChIP-Seq_LNCAP_Human2.07281278
18* FLI1_27457419_Chip-Seq_LIVER_Mouse2.04572528
19TAF15_26573619_Chip-Seq_HEK293_Human2.04150142
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.02378249
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.01769397
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.01769397
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.01769397
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01677329
25GATA1_22025678_ChIP-Seq_K562_Human1.99988335
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.98866553
27SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.97550367
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.96408622
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.95834563
30GBX2_23144817_ChIP-Seq_PC3_Human1.84905267
31PKCTHETA_26484144_Chip-Seq_BREAST_Human1.83580997
32* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.79008329
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75762802
34* EWS_26573619_Chip-Seq_HEK293_Human1.71651368
35TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.70567017
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.69970915
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.69103832
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.68784989
39TCF3_18692474_ChIP-Seq_MESCs_Mouse1.64429259
40IGF1R_20145208_ChIP-Seq_DFB_Human1.61937707
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61787629
42* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61514065
43* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58721752
44STAT3_23295773_ChIP-Seq_U87_Human1.58500470
45* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58363691
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57814415
47SMAD4_21799915_ChIP-Seq_A2780_Human1.57422845
48* P300_19829295_ChIP-Seq_ESCs_Human1.56046374
49* TCF7_22412390_ChIP-Seq_EML_Mouse1.53879055
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48396042
51RUNX_20019798_ChIP-Seq_JUKART_Human1.48183307
52* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48010658
53FOXM1_26456572_ChIP-Seq_MCF-7_Human1.47872872
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47063307
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46050975
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45054576
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44652002
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43305560
59* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.42169186
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41123047
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41087922
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.40412979
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.40326548
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39347139
65TCF4_23295773_ChIP-Seq_U87_Human1.38761436
66NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.36833686
67* EZH2_27294783_Chip-Seq_NPCs_Mouse1.35669507
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35270613
69* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34968241
70* NANOG_18555785_Chip-Seq_ESCs_Mouse1.32973822
71SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.31997491
72KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31150529
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.30987731
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.30790648
75ER_23166858_ChIP-Seq_MCF-7_Human1.30774477
76* E2F1_18555785_Chip-Seq_ESCs_Mouse1.29308627
77* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28559867
78* KDM2B_26808549_Chip-Seq_DND41_Human1.27030708
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26649309
80NANOG_21062744_ChIP-ChIP_HESCs_Human1.25730852
81FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.25522792
82CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25456503
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.24502041
84CHD1_26751641_Chip-Seq_LNCaP_Human1.23978849
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23762786
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23548599
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23373689
88ZNF274_21170338_ChIP-Seq_K562_Hela1.23162683
89* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22597608
90CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20547813
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20185640
92* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20165151
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.19897596
94* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19147417
95* NFE2_27457419_Chip-Seq_LIVER_Mouse1.16732773
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16420624
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16065413
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15967342
99SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.15908545
100AHR_22903824_ChIP-Seq_MCF-7_Human1.14825099
101KDM5A_27292631_Chip-Seq_BREAST_Human1.14179956
102PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14162077
103* CMYC_18555785_Chip-Seq_ESCs_Mouse1.13523239
104CBP_20019798_ChIP-Seq_JUKART_Human1.13345179
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13345179
106P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13180415
107* BRD4_25478319_ChIP-Seq_HGPS_Human1.12626005
108FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11973045
109MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11779084
110* P53_22387025_ChIP-Seq_ESCs_Mouse1.11710109
111* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11628259
112TP53_16413492_ChIP-PET_HCT116_Human1.11359400
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11330190
114GATA6_25053715_ChIP-Seq_YYC3_Human1.11106381
115ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10248919
116TCF4_18268006_ChIP-ChIP_LS174T_Human1.09420497
117RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08274637
118* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07735307
119CDX2_22108803_ChIP-Seq_LS180_Human1.07487626
120FLI1_21867929_ChIP-Seq_TH2_Mouse1.07341354
121MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06679365
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06369697
123NCOR1_26117541_ChIP-Seq_K562_Human1.06256187
124ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05894302
125TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.05603704
126* OCT4_18555785_Chip-Seq_ESCs_Mouse1.05253571
127VDR_22108803_ChIP-Seq_LS180_Human1.04881996
128RUNX2_22187159_ChIP-Seq_PCA_Human1.04869911
129TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04622055
130SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04388746
131POU5F1_16518401_ChIP-PET_MESCs_Mouse1.03870233
132FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.03294605
133TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02527518
134PRDM14_20953172_ChIP-Seq_ESCs_Human1.02470770
135* KDM2B_26808549_Chip-Seq_JURKAT_Human1.02212202
136MYB_26560356_Chip-Seq_TH1_Human1.01895730
137* P300_18555785_Chip-Seq_ESCs_Mouse1.01370357
138* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01258308
139NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00849548
140MYC_19079543_ChIP-ChIP_MESCs_Mouse1.00580308
141PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00567752
142NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00529022
143POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00336515
144* NMYC_18555785_Chip-Seq_ESCs_Mouse0.99884630
145CIITA_25753668_ChIP-Seq_RAJI_Human0.99595456
146CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99067944
147NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98894966
148TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98872163
149CLOCK_20551151_ChIP-Seq_293T_Human0.98819580
150TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98485918
151PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98471647
152STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98444672
153TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93822923
154YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93506362
155STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93217646
156KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92385829
157MYC_18555785_ChIP-Seq_MESCs_Mouse0.91890960
158UTX_26944678_Chip-Seq_JUKART_Human0.90610198
159ISL1_27105846_Chip-Seq_CPCs_Mouse0.89988318
160DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89687351
161SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87938459
162SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87883663
163CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87441198
164POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.87378647
165CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86821034
166PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.84471184
167ATF3_27146783_Chip-Seq_COLON_Human0.83945104
168ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83908460
169* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.82529420
170ZNF263_19887448_ChIP-Seq_K562_Human0.81816748

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002234_abnormal_pharynx_morphology3.13082419
2MP0003787_abnormal_imprinting2.99071594
3MP0010352_gastrointestinal_tract_polyps2.89783497
4MP0003705_abnormal_hypodermis_morpholog2.84730213
5MP0008057_abnormal_DNA_replication2.83945275
6MP0005076_abnormal_cell_differentiation2.81640825
7MP0000569_abnormal_digit_pigmentation2.81476435
8MP0010094_abnormal_chromosome_stability2.74010391
9MP0010307_abnormal_tumor_latency2.70270538
10MP0003111_abnormal_nucleus_morphology2.68954461
11MP0003077_abnormal_cell_cycle2.50227873
12MP0004264_abnormal_extraembryonic_tissu2.44822928
13MP0003693_abnormal_embryo_hatching2.40672511
14MP0003890_abnormal_embryonic-extraembry2.39040348
15MP0003763_abnormal_thymus_physiology2.32374063
16MP0004957_abnormal_blastocyst_morpholog2.25011979
17MP0002877_abnormal_melanocyte_morpholog2.22615660
18MP0003121_genomic_imprinting2.16172173
19MP0008877_abnormal_DNA_methylation2.08085402
20MP0000350_abnormal_cell_proliferation2.04787460
21MP0001730_embryonic_growth_arrest2.04466633
22MP0010234_abnormal_vibrissa_follicle2.04157070
23MP0001849_ear_inflammation2.00533739
24MP0002084_abnormal_developmental_patter1.99039261
25MP0001672_abnormal_embryogenesis/_devel1.98543893
26MP0005380_embryogenesis_phenotype1.98543893
27MP0001873_stomach_inflammation1.95198632
28MP0002086_abnormal_extraembryonic_tissu1.90061644
29MP0003984_embryonic_growth_retardation1.88851718
30MP0004185_abnormal_adipocyte_glucose1.88453924
31MP0002088_abnormal_embryonic_growth/wei1.85581443
32MP0004197_abnormal_fetal_growth/weight/1.84869758
33MP0002085_abnormal_embryonic_tissue1.72863470
34MP0002396_abnormal_hematopoietic_system1.70963563
35MP0003868_abnormal_feces_composition1.70944973
36MP0004130_abnormal_muscle_cell1.70512596
37MP0005248_abnormal_Harderian_gland1.67292292
38MP0001697_abnormal_embryo_size1.66689476
39MP0000465_gastrointestinal_hemorrhage1.65796391
40MP0001851_eye_inflammation1.62631014
41MP0003566_abnormal_cell_adhesion1.62380605
42MP0003221_abnormal_cardiomyocyte_apopto1.61179995
43MP0010030_abnormal_orbit_morphology1.53857413
44MP0000733_abnormal_muscle_development1.53175953
45MP0003123_paternal_imprinting1.50588896
46MP0003567_abnormal_fetal_cardiomyocyte1.50176843
47MP0008007_abnormal_cellular_replicative1.47361904
48MP0009703_decreased_birth_body1.44665272
49MP0004808_abnormal_hematopoietic_stem1.43449138
50MP0003937_abnormal_limbs/digits/tail_de1.39044724
51MP0001293_anophthalmia1.38745670
52MP0008995_early_reproductive_senescence1.34322875
53MP0003300_gastrointestinal_ulcer1.29574267
54MP0002080_prenatal_lethality1.29507915
55MP0001915_intracranial_hemorrhage1.28696578
56MP0000537_abnormal_urethra_morphology1.23148475
57MP0009672_abnormal_birth_weight1.22220939
58MP0003122_maternal_imprinting1.22008434
59MP0000432_abnormal_head_morphology1.21508086
60MP0000428_abnormal_craniofacial_morphol1.21213796
61MP0003935_abnormal_craniofacial_develop1.20860819
62MP0009053_abnormal_anal_canal1.19644416
63MP0009115_abnormal_fat_cell1.17134600
64MP0002092_abnormal_eye_morphology1.12844022
65MP0005023_abnormal_wound_healing1.12511992
66MP0002925_abnormal_cardiovascular_devel1.11532317
67MP0002697_abnormal_eye_size1.10141910
68MP0006054_spinal_hemorrhage1.09214585
69MP0003656_abnormal_erythrocyte_physiolo1.08953262
70MP0009697_abnormal_copulation1.07861401
71MP0003119_abnormal_digestive_system1.07777277
72MP0009278_abnormal_bone_marrow1.07617935
73MP0008058_abnormal_DNA_repair1.06064588
74MP0010678_abnormal_skin_adnexa1.05783325
75MP0002009_preneoplasia1.04596719
76MP0005257_abnormal_intraocular_pressure1.03721176
77MP0003045_fibrosis1.03392751
78MP0003091_abnormal_cell_migration1.01172861
79MP0008932_abnormal_embryonic_tissue1.00662048
80MP0001545_abnormal_hematopoietic_system1.00380840
81MP0005397_hematopoietic_system_phenotyp1.00380840
82MP0000427_abnormal_hair_cycle1.00053591
83MP0001286_abnormal_eye_development0.99673360
84MP0003252_abnormal_bile_duct0.98418623
85MP0006292_abnormal_olfactory_placode0.98411317
86MP0003453_abnormal_keratinocyte_physiol0.97152377
87MP0003755_abnormal_palate_morphology0.93026098
88MP0003115_abnormal_respiratory_system0.92939913
89MP0002019_abnormal_tumor_incidence0.90241315
90MP0010630_abnormal_cardiac_muscle0.89814405
91MP0005367_renal/urinary_system_phenotyp0.87295814
92MP0000516_abnormal_urinary_system0.87295814
93MP0000266_abnormal_heart_morphology0.84386993
94MP0002177_abnormal_outer_ear0.84011463
95MP0005666_abnormal_adipose_tissue0.83337394
96MP0005334_abnormal_fat_pad0.83314516
97MP0000627_abnormal_mammary_gland0.83255350
98MP0005220_abnormal_exocrine_pancreas0.82992161
99MP0000490_abnormal_crypts_of0.82411955
100MP0003950_abnormal_plasma_membrane0.80491595
101MP0000313_abnormal_cell_death0.80324844
102MP0001177_atelectasis0.80295171
103MP0002928_abnormal_bile_duct0.79929632
104MP0005621_abnormal_cell_physiology0.79514229
105MP0003699_abnormal_female_reproductive0.79278624
106MP0000383_abnormal_hair_follicle0.77976547
107MP0001666_abnormal_nutrient_absorption0.77934842
108MP0003195_calcinosis0.76154364
109MP0002166_altered_tumor_susceptibility0.75710927
110MP0001784_abnormal_fluid_regulation0.74661194
111MP0003718_maternal_effect0.74447674
112MP0005623_abnormal_meninges_morphology0.74438403
113MP0000703_abnormal_thymus_morphology0.73758189
114MP0008775_abnormal_heart_ventricle0.73630008
115MP0002006_tumorigenesis0.73543225
116MP0002398_abnormal_bone_marrow0.73384854
117MP0005187_abnormal_penis_morphology0.73030758
118MP0000631_abnormal_neuroendocrine_gland0.72940450
119MP0004084_abnormal_cardiac_muscle0.72194220
120MP0000371_diluted_coat_color0.71589261
121MP0002233_abnormal_nose_morphology0.70756295
122MP0004484_altered_response_of0.70590217
123MP0003632_abnormal_nervous_system0.69609179
124MP0003861_abnormal_nervous_system0.68217858
125MP0002909_abnormal_adrenal_gland0.67869217
126MP0000689_abnormal_spleen_morphology0.67020908
127MP0005174_abnormal_tail_pigmentation0.66751026
128MP0002249_abnormal_larynx_morphology0.66238384
129MP0003943_abnormal_hepatobiliary_system0.65611430
130MP0002111_abnormal_tail_morphology0.65364757
131MP0001929_abnormal_gametogenesis0.64858656
132MP0001119_abnormal_female_reproductive0.64676182
133MP0002722_abnormal_immune_system0.64360057
134MP0005395_other_phenotype0.64113139
135MP0005647_abnormal_sex_gland0.63480029
136MP0009780_abnormal_chondrocyte_physiolo0.62893040
137MP0008770_decreased_survivor_rate0.62698157
138MP0008961_abnormal_basal_metabolism0.62430422
139MP0001800_abnormal_humoral_immune0.61047343
140MP0003786_premature_aging0.60742668
141MP0002102_abnormal_ear_morphology0.59814023

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)5.19078147
2Neonatal hypoglycemia (HP:0001998)4.78156243
3Volvulus (HP:0002580)4.57592051
4Abnormal delayed hypersensitivity skin test (HP:0002963)4.34139732
5Autoimmune thrombocytopenia (HP:0001973)4.12672065
6Abnormality of T cell number (HP:0011839)4.00849163
7Chin dimple (HP:0010751)3.62216576
8Abnormality of the fingertips (HP:0001211)3.61306472
9Hypochromic microcytic anemia (HP:0004840)3.25285438
10Hypochromic anemia (HP:0001931)3.08318603
11Abnormality of the astrocytes (HP:0100707)3.05126136
12Astrocytoma (HP:0009592)3.05126136
13Neoplasm of the oral cavity (HP:0100649)3.00197820
14Ependymoma (HP:0002888)2.94229520
15Abnormality of the labia minora (HP:0012880)2.90266885
16Depressed nasal tip (HP:0000437)2.85088878
17Glucose intolerance (HP:0000833)2.84965996
18Nephroblastoma (Wilms tumor) (HP:0002667)2.80544326
19Papillary thyroid carcinoma (HP:0002895)2.79744152
20Chromsome breakage (HP:0040012)2.77697009
21Abnormality of the columella (HP:0009929)2.76414231
22Thyroid carcinoma (HP:0002890)2.72777937
23Embryonal renal neoplasm (HP:0011794)2.69915922
24Insulin-resistant diabetes mellitus (HP:0000831)2.66961049
25Long eyelashes (HP:0000527)2.59879628
26Acute lymphatic leukemia (HP:0006721)2.59540119
27Hypoplasia of the iris (HP:0007676)2.57865488
28Glioma (HP:0009733)2.56937987
29Heterotopia (HP:0002282)2.56933081
30Lip pit (HP:0100267)2.53446063
31Shawl scrotum (HP:0000049)2.51893979
32Hyperglycemia (HP:0003074)2.49968364
33Hepatoblastoma (HP:0002884)2.47919952
34Rhabdomyosarcoma (HP:0002859)2.46599655
35Biliary tract neoplasm (HP:0100574)2.46159425
36Cupped ear (HP:0000378)2.44759383
37Increased IgM level (HP:0003496)2.44251811
38Facial hemangioma (HP:0000329)2.42315975
39Subacute progressive viral hepatitis (HP:0006572)2.41222085
40Eosinophilia (HP:0001880)2.40446449
41Abnormal glucose tolerance (HP:0001952)2.39580577
42Medulloblastoma (HP:0002885)2.38447227
43Gastrointestinal carcinoma (HP:0002672)2.37987701
44Malignant gastrointestinal tract tumors (HP:0006749)2.37987701
45Absent frontal sinuses (HP:0002688)2.32594103
46Shallow orbits (HP:0000586)2.32198342
47Prominent nose (HP:0000448)2.31559096
48Acute myeloid leukemia (HP:0004808)2.30986265
49Macroorchidism (HP:0000053)2.29668508
50Ectopic kidney (HP:0000086)2.29076220
51Urethral obstruction (HP:0000796)2.27036537
52Increased nuchal translucency (HP:0010880)2.26595103
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.25677516
54Menstrual irregularities (HP:0000858)2.24817505
55Short 4th metacarpal (HP:0010044)2.23745243
56Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.23745243
57Deviation of the thumb (HP:0009603)2.23678318
58Fair hair (HP:0002286)2.22454847
59Sandal gap (HP:0001852)2.20031763
60Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.19480029
61T lymphocytopenia (HP:0005403)2.18937044
62Premature skin wrinkling (HP:0100678)2.18540282
63Truncal obesity (HP:0001956)2.18234188
64Broad thumb (HP:0011304)2.17740136
65IgM deficiency (HP:0002850)2.15413056
66Obsessive-compulsive behavior (HP:0000722)2.14868168
67Enlarged epiphyses (HP:0010580)2.14067333
68Ulnar bowing (HP:0003031)2.13634146
69Abnormality of the renal cortex (HP:0011035)2.11880613
70Neoplasm of striated muscle (HP:0009728)2.11585706
71Transitional cell carcinoma of the bladder (HP:0006740)2.10826254
72Supernumerary bones of the axial skeleton (HP:0009144)2.08448980
73Abnormality of the nasal septum (HP:0000419)2.08251749
74Narrow palate (HP:0000189)2.06524497
75Supernumerary ribs (HP:0005815)2.05635543
76Proximal placement of thumb (HP:0009623)2.05477385
77Cerebral aneurysm (HP:0004944)2.03067615
78Leiomyosarcoma (HP:0100243)2.01975912
79Uterine leiomyosarcoma (HP:0002891)2.01975912
80Deep philtrum (HP:0002002)2.00974465
81Abnormality of chromosome stability (HP:0003220)1.99929374
82Central scotoma (HP:0000603)1.98238728
83Abnormality of eosinophils (HP:0001879)1.97801069
84Impulsivity (HP:0100710)1.97542667
85Gaze-evoked nystagmus (HP:0000640)1.97109548
86Hypoplastic labia majora (HP:0000059)1.95788240
87Abnormality of T cells (HP:0002843)1.95729067
88Rib fusion (HP:0000902)1.95591234
89Neoplasm of the tracheobronchial system (HP:0100552)1.94965144
90Neoplasm of the small intestine (HP:0100833)1.94815792
91Subaortic stenosis (HP:0001682)1.94649323
92Abnormality of the left ventricular outflow tract (HP:0011103)1.94649323
93Spontaneous hematomas (HP:0007420)1.94156774
94Abnormality of T cell physiology (HP:0011840)1.93997053
95Difficulty running (HP:0009046)1.92723817
96Broad nasal tip (HP:0000455)1.91626164
97Anal stenosis (HP:0002025)1.90618660
98Smooth philtrum (HP:0000319)1.89685325
99Hypoplastic ischia (HP:0003175)1.88894222
100Tubulointerstitial nephritis (HP:0001970)1.87673628
101Hyperacusis (HP:0010780)1.86984540
102Sparse lateral eyebrow (HP:0005338)1.86317839
103Bladder neoplasm (HP:0009725)1.85087145
104Bladder carcinoma (HP:0002862)1.85087145
105Stomach cancer (HP:0012126)1.83586927
106Areflexia of lower limbs (HP:0002522)1.83484854
107Cortical dysplasia (HP:0002539)1.83183325
108Vertebral arch anomaly (HP:0008438)1.82543490
109Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.81628589
110Colon cancer (HP:0003003)1.81343650
111Granulocytopenia (HP:0001913)1.81212312
112Acanthocytosis (HP:0001927)1.78819628
113Curly hair (HP:0002212)1.78125614
114Abnormal hair whorl (HP:0010721)1.77752933
115Oligodactyly (hands) (HP:0001180)1.76800995
116Cystic hygroma (HP:0000476)1.76769407
117Trigonocephaly (HP:0000243)1.76485424
118Skull defect (HP:0001362)1.76307102
119Abnormality of the labia majora (HP:0012881)1.74350213
120Low anterior hairline (HP:0000294)1.73245416
121Cafe-au-lait spot (HP:0000957)1.71454968
122Uterine neoplasm (HP:0010784)1.70986362
123Short chin (HP:0000331)1.69977104
124Abnormal biliary tract morphology (HP:0012440)1.69093953
125Dental malocclusion (HP:0000689)1.68113096
126Abnormal pancreas size (HP:0012094)1.67221809
127Enlarged penis (HP:0000040)1.67172314
128Pancreatic islet-cell hyperplasia (HP:0004510)1.67101053
129Thick eyebrow (HP:0000574)1.66547035
130Limited elbow extension (HP:0001377)1.66382150
131Anterior segment dysgenesis (HP:0007700)1.66348226
132High pitched voice (HP:0001620)1.65829115
133Gonadotropin excess (HP:0000837)1.65690262
134Renovascular hypertension (HP:0100817)1.64979282
135Patellar aplasia (HP:0006443)1.64970961
136Aplasia/Hypoplasia of the sternum (HP:0006714)1.64960291
137Underdeveloped nasal alae (HP:0000430)1.64041427
138Broad phalanges of the hand (HP:0009768)1.63355210
139Myelodysplasia (HP:0002863)1.63097188
140Abnormality of the 4th metacarpal (HP:0010012)1.62094930
141Midline defect of the nose (HP:0004122)1.61870836
142Abnormality of chromosome segregation (HP:0002916)1.61451672
143Hemivertebrae (HP:0002937)1.61219266
144Aqueductal stenosis (HP:0002410)1.61023385
145Selective tooth agenesis (HP:0001592)1.60738696
146Intestinal atresia (HP:0011100)1.59927390
147Genu recurvatum (HP:0002816)1.59831176
148Abnormality of the ischium (HP:0003174)1.59070628
149Embryonal neoplasm (HP:0002898)1.58256518
150Ectropion (HP:0000656)1.58085721
151Pseudobulbar signs (HP:0002200)1.57379249
152Basal cell carcinoma (HP:0002671)1.57222721
153Abnormality of cells of the lymphoid lineage (HP:0012140)1.56811449
154Broad palm (HP:0001169)1.56191310
155Oligodactyly (HP:0012165)1.55925166
156Genetic anticipation (HP:0003743)1.55492889
157Hematochezia (HP:0002573)1.55201645
158Epileptic encephalopathy (HP:0200134)1.55151565
159Dysmetric saccades (HP:0000641)1.54715423
160Birth length less than 3rd percentile (HP:0003561)1.54693185
161Rectal prolapse (HP:0002035)1.54649365
162Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.54403165
163Widely spaced teeth (HP:0000687)1.54363186
164Aneurysm (HP:0002617)1.54145240
165Hypopigmentation of the fundus (HP:0007894)1.54087009
166Skin tags (HP:0010609)1.53455748
167Scotoma (HP:0000575)1.52817333
168Thyroiditis (HP:0100646)1.52709087
169Abnormal number of incisors (HP:0011064)1.51130974

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.76495979
2LATS14.80595148
3PIK3CA4.34917711
4TLK13.98378516
5CDC73.06323371
6STK32.20244578
7NEK22.18961289
8CAMK1D2.07797036
9MAP3K41.99518552
10TTK1.90872384
11NLK1.89314884
12BRD41.88712930
13CDK61.84531190
14LATS21.81925809
15EEF2K1.81832333
16STK38L1.69531348
17MAP3K61.68247768
18PKN21.66654220
19EPHA21.62018286
20CAMK1G1.60854064
21CAMKK21.56369985
22STK101.52396567
23MTOR1.48448696
24ACVR1B1.47505952
25OXSR11.46459771
26CHEK21.45458107
27TEC1.43697249
28ALK1.43182442
29PDGFRA1.41578205
30MELK1.33548393
31CDK41.32180056
32MAP3K21.31833448
33TNIK1.30167527
34FGFR31.28074591
35CHEK11.27088712
36MAP3K101.26396207
37CDK191.26341274
38TAOK31.24563307
39RPS6KB21.21658110
40NUAK11.20540084
41SRPK11.19978643
42DMPK1.18624826
43CDK71.16935806
44ATR1.14352929
45SIK11.14299449
46FRK1.13728348
47ATM1.12689332
48PDGFRB1.08544118
49BMPR21.05031646
50SGK2231.04609991
51SGK4941.04609991
52YES11.03944058
53CDK91.03251544
54EIF2AK31.03137273
55AURKB1.02244006
56TYRO31.01947282
57BMPR1B1.00845427
58RIPK11.00429524
59ICK0.98087254
60STK40.97455351
61SCYL20.96239282
62CDK20.94091407
63ERBB40.93925621
64MARK30.93844710
65PLK40.92018286
66STK380.91963529
67TRPM70.91822111
68SGK30.90235959
69PLK10.90116759
70DDR20.89172481
71FGFR20.85928589
72TRIB30.84284562
73CSNK1D0.83837970
74BTK0.81960878
75TAOK10.81870673
76MAP3K80.81733162
77PIK3CG0.81053227
78ERBB30.80655856
79MST40.80193650
80DYRK1A0.79974332
81CHUK0.77295657
82MAP2K20.77104572
83PIM10.74293753
84CDK10.74057561
85RPS6KA40.73376870
86PTK60.72226757
87MKNK20.71207576
88TTN0.71110612
89STK390.70464483
90CASK0.70426873
91BMX0.70106734
92MAP4K20.69614361
93WNK10.69016541
94SGK10.68579065
95* MAPK140.68534639
96MAP2K40.68367788
97PLK30.67943258
98CSNK1E0.67178328
99PNCK0.67008068
100MAPK100.66808291
101STK110.66436222
102RET0.65800514
103AKT30.65353031
104PRKD20.63156079
105OBSCN0.63008304
106TNK20.60759629
107KIT0.59431746
108FGFR10.58946384
109PAK20.57124552
110MAPK10.56116101
111ZAK0.56064513
112GSK3B0.55286915
113NEK10.55014054
114PRKAA10.54880937
115PRKDC0.54007563
116JAK20.53726090
117FLT30.53375984
118PASK0.53299431
119CAMK40.52958653
120PRKAA20.51542321
121AKT10.51016413
122PTK20.50002859
123JAK10.49742066
124HIPK20.49222316
125SIK20.48421319
126BRSK20.48186449
127RPS6KB10.47487545
128ERBB20.47373813
129LCK0.47147774
130MAP2K30.47099873
131SGK20.46824090
132CSNK1A1L0.45682972
133EIF2AK10.45228216
134MAP3K70.44311232
135NEK60.44117904
136NEK90.43702661
137MAPK120.43617673
138PRKD30.42883647
139MKNK10.42164131
140CSNK1G10.42029451
141EGFR0.41768804
142MAPK80.41685810
143MAPK110.41300878
144MAP2K10.40934526
145DYRK1B0.40898236
146CDK80.40469444
147WNK30.38551891
148TIE10.37992722
149ITK0.35565300
150TGFBR20.34015972
151PRKG10.33983625
152HCK0.33916784

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.16208008
2Lysine degradation_Homo sapiens_hsa003102.03136020
3Adherens junction_Homo sapiens_hsa045201.97846347
4MicroRNAs in cancer_Homo sapiens_hsa052061.94681766
5RNA transport_Homo sapiens_hsa030131.92948787
6Caffeine metabolism_Homo sapiens_hsa002321.83133695
7mTOR signaling pathway_Homo sapiens_hsa041501.78855052
8mRNA surveillance pathway_Homo sapiens_hsa030151.76852221
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66543443
10Chronic myeloid leukemia_Homo sapiens_hsa052201.62371306
11Small cell lung cancer_Homo sapiens_hsa052221.57921572
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.57365625
13Type I diabetes mellitus_Homo sapiens_hsa049401.56937050
14Mismatch repair_Homo sapiens_hsa034301.53418522
15Non-homologous end-joining_Homo sapiens_hsa034501.48701244
16p53 signaling pathway_Homo sapiens_hsa041151.48127826
17Colorectal cancer_Homo sapiens_hsa052101.46059425
18Fanconi anemia pathway_Homo sapiens_hsa034601.44759563
19Autoimmune thyroid disease_Homo sapiens_hsa053201.44527350
20Allograft rejection_Homo sapiens_hsa053301.43333523
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.42183699
22Dorso-ventral axis formation_Homo sapiens_hsa043201.40913540
23Graft-versus-host disease_Homo sapiens_hsa053321.39740747
24One carbon pool by folate_Homo sapiens_hsa006701.38923489
25Endometrial cancer_Homo sapiens_hsa052131.38582538
26African trypanosomiasis_Homo sapiens_hsa051431.37856606
27Hippo signaling pathway_Homo sapiens_hsa043901.36822783
28Nitrogen metabolism_Homo sapiens_hsa009101.35261441
29Pancreatic cancer_Homo sapiens_hsa052121.34499811
30RNA degradation_Homo sapiens_hsa030181.34145197
31TGF-beta signaling pathway_Homo sapiens_hsa043501.34106429
32Measles_Homo sapiens_hsa051621.33550819
33Non-small cell lung cancer_Homo sapiens_hsa052231.32222664
34Prostate cancer_Homo sapiens_hsa052151.30421627
35Viral carcinogenesis_Homo sapiens_hsa052031.27901670
36Notch signaling pathway_Homo sapiens_hsa043301.25587589
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25074953
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24469318
39Proteoglycans in cancer_Homo sapiens_hsa052051.23927183
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20848258
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18155790
42Basal cell carcinoma_Homo sapiens_hsa052171.16202342
43Spliceosome_Homo sapiens_hsa030401.13988648
44Vitamin B6 metabolism_Homo sapiens_hsa007501.13768463
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.11485461
46Systemic lupus erythematosus_Homo sapiens_hsa053221.10827900
47HTLV-I infection_Homo sapiens_hsa051661.10224683
48FoxO signaling pathway_Homo sapiens_hsa040681.09325861
49Selenocompound metabolism_Homo sapiens_hsa004501.07458769
50Influenza A_Homo sapiens_hsa051641.07410278
51Thyroid cancer_Homo sapiens_hsa052161.04734789
52Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04105335
53Basal transcription factors_Homo sapiens_hsa030221.01692435
54Herpes simplex infection_Homo sapiens_hsa051681.00214373
55Focal adhesion_Homo sapiens_hsa045100.98304418
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97973956
57Wnt signaling pathway_Homo sapiens_hsa043100.97725220
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96310200
59Renal cell carcinoma_Homo sapiens_hsa052110.94801803
60Prolactin signaling pathway_Homo sapiens_hsa049170.93177848
61DNA replication_Homo sapiens_hsa030300.91564916
62Homologous recombination_Homo sapiens_hsa034400.90879752
63Pathways in cancer_Homo sapiens_hsa052000.89477326
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88505935
65Glioma_Homo sapiens_hsa052140.88282481
66Hepatitis B_Homo sapiens_hsa051610.87978975
67Insulin resistance_Homo sapiens_hsa049310.86177567
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84656600
69Acute myeloid leukemia_Homo sapiens_hsa052210.84535433
70Tight junction_Homo sapiens_hsa045300.84502822
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83444676
72Type II diabetes mellitus_Homo sapiens_hsa049300.82774579
73Circadian rhythm_Homo sapiens_hsa047100.81875403
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81492030
75Oocyte meiosis_Homo sapiens_hsa041140.79475338
76Choline metabolism in cancer_Homo sapiens_hsa052310.79459089
77Hedgehog signaling pathway_Homo sapiens_hsa043400.78758717
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78563282
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78251584
80ErbB signaling pathway_Homo sapiens_hsa040120.78083063
81Base excision repair_Homo sapiens_hsa034100.76799577
82AMPK signaling pathway_Homo sapiens_hsa041520.75243661
83Renin secretion_Homo sapiens_hsa049240.75162930
84Bladder cancer_Homo sapiens_hsa052190.74822858
85Propanoate metabolism_Homo sapiens_hsa006400.73307369
86Inositol phosphate metabolism_Homo sapiens_hsa005620.73274319
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.72165919
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71666620
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71493783
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71397731
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70836834
92Melanoma_Homo sapiens_hsa052180.69909913
93Viral myocarditis_Homo sapiens_hsa054160.69604329
94ECM-receptor interaction_Homo sapiens_hsa045120.68523549
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67132511
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.66017703
97Fatty acid biosynthesis_Homo sapiens_hsa000610.64921670
98Estrogen signaling pathway_Homo sapiens_hsa049150.64603858
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62739286
100Platelet activation_Homo sapiens_hsa046110.62610704
101Insulin signaling pathway_Homo sapiens_hsa049100.62341468
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61646861
103B cell receptor signaling pathway_Homo sapiens_hsa046620.61103303
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.61102883
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.60933087
106Ras signaling pathway_Homo sapiens_hsa040140.60303534
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58862159
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.58691716
109Leishmaniasis_Homo sapiens_hsa051400.58567713
110MAPK signaling pathway_Homo sapiens_hsa040100.58422973
111Hepatitis C_Homo sapiens_hsa051600.57550666
112Rap1 signaling pathway_Homo sapiens_hsa040150.57242917
113Toxoplasmosis_Homo sapiens_hsa051450.56622322
114Antigen processing and presentation_Homo sapiens_hsa046120.56616808
115T cell receptor signaling pathway_Homo sapiens_hsa046600.56419038
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56250215
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54096505
118cAMP signaling pathway_Homo sapiens_hsa040240.53444131
119Amoebiasis_Homo sapiens_hsa051460.53178506
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52632637
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52391737
122TNF signaling pathway_Homo sapiens_hsa046680.52350569
123Nucleotide excision repair_Homo sapiens_hsa034200.52151272
124HIF-1 signaling pathway_Homo sapiens_hsa040660.51791323
125VEGF signaling pathway_Homo sapiens_hsa043700.51275567
126Long-term potentiation_Homo sapiens_hsa047200.51049007
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.50686979
128Apoptosis_Homo sapiens_hsa042100.50347532
129Glucagon signaling pathway_Homo sapiens_hsa049220.50148474
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.50089305
131Alcoholism_Homo sapiens_hsa050340.49103417
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.48101152
133Regulation of autophagy_Homo sapiens_hsa041400.47094592

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