PHF7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. This gene is expressed in the testis in Sertoli cells but not germ cells. The protein encoded by this gene contains plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. The protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Alternate splicing results in multiple transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.91558068
2cell-cell recognition (GO:0009988)9.90678303
3spermatid development (GO:0007286)9.69470989
4plasma membrane fusion (GO:0045026)9.59475650
5epithelial cilium movement (GO:0003351)9.58984103
6motile cilium assembly (GO:0044458)9.33407052
7male meiosis (GO:0007140)8.82500819
8reproduction (GO:0000003)8.67292361
9synaptonemal complex organization (GO:0070193)8.45280656
10response to pheromone (GO:0019236)8.33301129
11regulation of cilium movement (GO:0003352)8.29302801
12cilium movement (GO:0003341)8.11492235
13synaptonemal complex assembly (GO:0007130)8.08097934
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.98243618
15negative regulation of inclusion body assembly (GO:0090084)7.27046474
16single fertilization (GO:0007338)7.15327789
17rRNA methylation (GO:0031167)7.13262618
18sperm capacitation (GO:0048240)6.77107510
19phosphatidylethanolamine biosynthetic process (GO:0006646)6.70395265
20spermatogenesis (GO:0007283)6.50420392
21male gamete generation (GO:0048232)6.48124084
22centriole replication (GO:0007099)6.47049863
23DNA methylation involved in gamete generation (GO:0043046)6.37684592
24protein targeting to Golgi (GO:0000042)6.37138910
25rRNA modification (GO:0000154)6.32210744
26fertilization (GO:0009566)6.31970662
27phosphatidylethanolamine metabolic process (GO:0046337)6.21475334
28male meiosis I (GO:0007141)6.20503385
29establishment of protein localization to Golgi (GO:0072600)6.15004862
30gamete generation (GO:0007276)5.95707312
31retrograde transport, vesicle recycling within Golgi (GO:0000301)5.92595743
32organic cation transport (GO:0015695)5.85354446
33regulation of inclusion body assembly (GO:0090083)5.82742292
34microtubule depolymerization (GO:0007019)5.68880777
35chromosome organization involved in meiosis (GO:0070192)5.64961606
36germ cell development (GO:0007281)5.54865608
37cellular process involved in reproduction in multicellular organism (GO:0022412)5.41036402
38cellular ketone body metabolic process (GO:0046950)5.36365322
39meiotic nuclear division (GO:0007126)5.24609399
40ventricular system development (GO:0021591)5.20094244
41seminiferous tubule development (GO:0072520)5.09999838
42meiosis I (GO:0007127)5.04729570
43RNA destabilization (GO:0050779)5.00334124
44calcium ion-dependent exocytosis (GO:0017156)4.94199137
45regulation of microtubule-based movement (GO:0060632)4.90098896
46ketone body metabolic process (GO:1902224)4.82588384
47protein localization to Golgi apparatus (GO:0034067)4.76723658
48cell recognition (GO:0008037)4.71116978
49multicellular organismal reproductive process (GO:0048609)4.67785530
50microtubule severing (GO:0051013)4.64477456
51chromosome condensation (GO:0030261)4.61697872
52regulation of Rab GTPase activity (GO:0032313)4.49001657
53positive regulation of Rab GTPase activity (GO:0032851)4.49001657
54meiotic cell cycle (GO:0051321)4.47215859
55DNA packaging (GO:0006323)4.45015225
56left/right pattern formation (GO:0060972)4.34502332
57glycerol ether metabolic process (GO:0006662)4.25373458
58spermatid nucleus differentiation (GO:0007289)4.17691818
59chaperone-mediated protein complex assembly (GO:0051131)4.10589606
60chromatin silencing (GO:0006342)4.09924255
61protein localization to cilium (GO:0061512)3.99001745
62genitalia morphogenesis (GO:0035112)3.97349427
63ether metabolic process (GO:0018904)3.92493542
64protein-DNA complex disassembly (GO:0032986)3.90735120
65nucleosome disassembly (GO:0006337)3.90735120
66multicellular organismal development (GO:0007275)3.78355474
67regulation of transcription involved in cell fate commitment (GO:0060850)3.72603180
68gene silencing by RNA (GO:0031047)3.67774078
69monoubiquitinated protein deubiquitination (GO:0035520)3.67075470
70microtubule nucleation (GO:0007020)3.62833097
71protein polyglutamylation (GO:0018095)3.61130931
72meiotic cell cycle process (GO:1903046)3.46885405
73protein refolding (GO:0042026)3.43061764
74synapsis (GO:0007129)3.37314417
75intraciliary transport (GO:0042073)3.37214497
76regulation of spindle checkpoint (GO:0090231)3.35881615
77polyamine biosynthetic process (GO:0006596)3.35372718
78mitotic sister chromatid cohesion (GO:0007064)3.28730495
79carnitine transport (GO:0015879)3.28510639
80amino-acid betaine transport (GO:0015838)3.28510639
81single strand break repair (GO:0000012)3.25534304
82coenzyme catabolic process (GO:0009109)3.23512965
83carnitine transmembrane transport (GO:1902603)3.20415868
84peptidyl-threonine dephosphorylation (GO:0035970)3.19292348
85homeostasis of number of cells within a tissue (GO:0048873)3.17072915
86mitochondrial fission (GO:0000266)3.14516555
87axoneme assembly (GO:0035082)3.13304317
88regulation of meiosis I (GO:0060631)3.12584015
89negative regulation of organelle assembly (GO:1902116)3.09251877
90negative regulation of gene expression, epigenetic (GO:0045814)3.09000389
91sexual reproduction (GO:0019953)3.07226443
92musculoskeletal movement (GO:0050881)3.07008124
93multicellular organismal movement (GO:0050879)3.07008124
94DNA conformation change (GO:0071103)3.04892420
95nucleus organization (GO:0006997)3.04721850
96microtubule-based movement (GO:0007018)3.04128581
97lactate metabolic process (GO:0006089)3.02167997
98glycolytic process (GO:0006096)3.01871136
99histone exchange (GO:0043486)3.01545044
100alditol metabolic process (GO:0019400)2.97455286
101NAD biosynthetic process (GO:0009435)2.96820669
102antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.94740602
103nucleoside diphosphate phosphorylation (GO:0006165)2.93873279
104polyol catabolic process (GO:0046174)2.91315558
105RNA methylation (GO:0001510)2.91136267
106nuclear pore complex assembly (GO:0051292)2.90827854
107cilium organization (GO:0044782)2.89217663
108response to acidic pH (GO:0010447)2.88427361
109negative regulation of Rho protein signal transduction (GO:0035024)2.87495323
110negative regulation of histone methylation (GO:0031061)2.86701303
111microtubule polymerization or depolymerization (GO:0031109)2.86415489
112gene silencing (GO:0016458)2.86413146
113membrane protein intracellular domain proteolysis (GO:0031293)2.85579024
114detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.82077403
115histone H3-K9 demethylation (GO:0033169)2.80190095
116regulation of centriole replication (GO:0046599)2.79614427
117protein K11-linked deubiquitination (GO:0035871)2.77733817
118regulation of phosphoprotein phosphatase activity (GO:0043666)2.75484174
119sequestering of actin monomers (GO:0042989)2.74228208
120cilium assembly (GO:0042384)2.72656562
121interferon-gamma secretion (GO:0072643)2.72267297
122regulation of histone H3-K9 methylation (GO:0051570)2.71541683
123cellular response to pH (GO:0071467)2.70457630
124cilium morphogenesis (GO:0060271)2.69135769
125cellular component assembly involved in morphogenesis (GO:0010927)2.68333244
126histone mRNA catabolic process (GO:0071044)2.66890986
127GTP biosynthetic process (GO:0006183)2.64566618
128peptidyl-glutamic acid modification (GO:0018200)2.58130988
129regulation of cilium assembly (GO:1902017)2.56434750
130glycerol metabolic process (GO:0006071)2.49059196
131centriole assembly (GO:0098534)2.48779946
132DNA alkylation (GO:0006305)2.46149853
133sperm motility (GO:0030317)13.2274258
134fusion of sperm to egg plasma membrane (GO:0007342)12.6365642
135cilium or flagellum-dependent cell motility (GO:0001539)12.3547291
136acrosome reaction (GO:0007340)11.2447065
137sperm-egg recognition (GO:0035036)11.0743145
138acrosome assembly (GO:0001675)11.0248642
139axonemal dynein complex assembly (GO:0070286)10.3306530
140binding of sperm to zona pellucida (GO:0007339)10.3032229
141multicellular organism reproduction (GO:0032504)10.2731119
142cell wall macromolecule catabolic process (GO:0016998)10.0107064
143cell wall macromolecule metabolic process (GO:0044036)10.0107064

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.22969895
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.21833093
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.86913926
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.03283524
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.62322933
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.58116294
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51114590
8VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.46849118
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.43536098
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.33117753
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.27623726
12EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.24024590
13ERA_21632823_ChIP-Seq_H3396_Human2.23320228
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.22966547
15RBPJ_21746931_ChIP-Seq_IB4-LCL_Human2.18960707
16VDR_22108803_ChIP-Seq_LS180_Human2.18742697
17BCL6_27268052_Chip-Seq_Bcells_Human2.16318248
18ZNF274_21170338_ChIP-Seq_K562_Hela2.15161615
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12510343
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.06144509
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00014196
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.0836644
23* RAC3_21632823_ChIP-Seq_H3396_Human1.97768474
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.96797557
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.94493102
26FUS_26573619_Chip-Seq_HEK293_Human1.92880363
27ELK4_26923725_Chip-Seq_MESODERM_Mouse1.84909703
28E2F1_20622854_ChIP-Seq_HELA_Human1.78596431
29FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72767547
30P300_27268052_Chip-Seq_Bcells_Human1.69809040
31MYC_19829295_ChIP-Seq_ESCs_Human1.69181313
32TAF2_19829295_ChIP-Seq_ESCs_Human1.68996628
33P68_20966046_ChIP-Seq_HELA_Human1.68644047
34ER_23166858_ChIP-Seq_MCF-7_Human1.62794637
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60961309
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59597997
37OCT4_20526341_ChIP-Seq_ESCs_Human1.58422570
38TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.57398005
39SOX2_22085726_ChIP-Seq_NPCs_Mouse1.56425638
40* STAT1_17558387_ChIP-Seq_HELA_Human1.56248519
41KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.52117324
42WDR5_24793694_ChIP-Seq_LNCAP_Human1.51748986
43CTCF_27219007_Chip-Seq_Bcells_Human1.51558895
44* SMC4_20622854_ChIP-Seq_HELA_Human1.48285758
45KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.47416758
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.46063521
47GATA3_21867929_ChIP-Seq_CD8_Mouse1.46059916
48GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.44806243
49CEBPB_22108803_ChIP-Seq_LS180_Human1.44266983
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44007017
51TDRD3_21172665_ChIP-Seq_MCF-7_Human1.43700024
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42734199
53MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.41952153
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.38495916
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36127723
56CBP_20019798_ChIP-Seq_JUKART_Human1.36127723
57* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35355932
58SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.33988229
59KAP1_22055183_ChIP-Seq_ESCs_Mouse1.33942531
60RBPJ_21746931_ChIP-Seq_IB4_Human1.33599929
61SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33268304
62* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.31807543
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.31458190
64HNFA_21074721_ChIP-Seq_CACO-2_Human1.30456413
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30101485
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.29372519
67* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.28006219
68P53_21459846_ChIP-Seq_SAOS-2_Human1.27942494
69CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.27160710
70* TP63_22573176_ChIP-Seq_HFKS_Human1.26821286
71ETV1_20927104_ChIP-Seq_GIST48_Human1.26611388
72SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26350760
73GATA1_19941826_ChIP-Seq_K562_Human1.25814437
74LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.25633418
75KDM2B_26808549_Chip-Seq_REH_Human1.25492710
76P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.25490303
77DROSHA_22980978_ChIP-Seq_HELA_Human1.24399410
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.22974816
79CBX2_22325352_ChIP-Seq_293T-Rex_Human1.22108109
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22031703
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.21752811
82PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20924601
83AR_25329375_ChIP-Seq_VCAP_Human1.19720157
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18812317
85SOX2_19829295_ChIP-Seq_ESCs_Human1.18257835
86NANOG_19829295_ChIP-Seq_ESCs_Human1.18257835
87SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.18233139
88SPI1_20517297_ChIP-Seq_HL60_Human1.18074856
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18068083
90RUNX_20019798_ChIP-Seq_JUKART_Human1.18009638
91GATA3_21867929_ChIP-Seq_TH1_Mouse1.17091119
92RAD21_21589869_ChIP-Seq_MESCs_Mouse1.16278882
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14381292
94PHF8_20622853_ChIP-Seq_HELA_Human1.14294021
95SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14147539
96GATA6_21074721_ChIP-Seq_CACO-2_Human1.14088982
97REST_21632747_ChIP-Seq_MESCs_Mouse1.13877232
98CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11515953
99GF1_26923725_Chip-Seq_HPCs_Mouse1.11246418
100ERG_20517297_ChIP-Seq_VCAP_Human1.09991076
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.09589860
102YY1_22570637_ChIP-Seq_MALME-3M_Human1.09352450
103RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08994469
104SMRT_27268052_Chip-Seq_Bcells_Human1.08679180
105RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08419618
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07686804
107FOXA1_25329375_ChIP-Seq_VCAP_Human1.07686804
108CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07409553
109SPI1_26923725_Chip-Seq_HPCs_Mouse1.06785955
110RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06450361
111SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05642975
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05132629
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05132629
114SA1_27219007_Chip-Seq_Bcells_Human1.04858643
115P300_19829295_ChIP-Seq_ESCs_Human1.04735648
116GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.04621094
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04522736
118NCOR_22424771_ChIP-Seq_293T_Human1.04225485
119PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03964342
120SCL_19346495_ChIP-Seq_HPC-7_Human1.03916579
121TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03506063
122NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03400162
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02984971
124GATA3_26560356_Chip-Seq_TH1_Human1.02626508
125TBL1_22424771_ChIP-Seq_293T_Human1.02360459
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01767270
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01263197
128STAT1_20625510_ChIP-Seq_HELA_Human1.00847296
129HOXB7_26014856_ChIP-Seq_BT474_Human1.00784865
130CTCF_21964334_Chip-Seq_Bcells_Human1.00520551
131MYC_27129775_Chip-Seq_CORNEA_Mouse1.00244131
132SMAD3_21741376_ChIP-Seq_ESCs_Human0.99986426
133PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99593157
134SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99340580
135E2F1_17053090_ChIP-ChIP_MCF-7_Human0.99296109
136ESET_19884257_ChIP-Seq_ESCs_Mouse0.98788459
137* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98724722
138RARA_24833708_ChIP-Seq_LIVER_Mouse0.98607237
139FOXP1_21924763_ChIP-Seq_HESCs_Human0.98439733
140OCT4_19829295_ChIP-Seq_ESCs_Human0.98362043
141SALL1_21062744_ChIP-ChIP_HESCs_Human0.98351140
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.96897711
143EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96008255
144RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95151745
145TET1_21451524_ChIP-Seq_MESCs_Mouse0.95022239
146TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94705197
147CBX2_27304074_Chip-Seq_ESCs_Mouse0.93000452
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92630779
149GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92186462
150ELF1_20517297_ChIP-Seq_JURKAT_Human0.92184319
151SOX2_21211035_ChIP-Seq_LN229_Human0.91967093
152RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91690354
153NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91073460
154LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90380318
155FLI1_21867929_ChIP-Seq_CD8_Mouse0.90245484
156CTCF_20526341_ChIP-Seq_ESCs_Human0.90197189
157SOX11_22085726_ChIP-Seq_ESNs_Mouse0.88657174
158TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88485104
159OCT4_18555785_Chip-Seq_ESCs_Mouse0.87857955
160NANOG_18555785_Chip-Seq_ESCs_Mouse0.87793578
161NANOG_20526341_ChIP-Seq_ESCs_Human0.87198145
162CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86961822
163* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85267713
164NFYB_21822215_ChIP-Seq_K562_Human0.84076044
165CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.83828669
166JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.83720922
167OCT4_21477851_ChIP-Seq_ESCs_Mouse0.83141651
168PHF8_20622854_ChIP-Seq_HELA_Human0.81893653
169MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81622042
170BCOR_27268052_Chip-Seq_Bcells_Human0.81387546
171NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.81322057

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.04886584
2MP0001929_abnormal_gametogenesis5.64899972
3MP0008877_abnormal_DNA_methylation5.21550692
4MP0002210_abnormal_sex_determination3.78980797
5MP0002161_abnormal_fertility/fecundity3.31294865
6MP0001145_abnormal_male_reproductive3.17123690
7MP0003718_maternal_effect3.00966517
8MP0000653_abnormal_sex_gland2.74624021
9MP0002653_abnormal_ependyma_morphology2.68467287
10MP0005670_abnormal_white_adipose2.31967418
11MP0002132_abnormal_respiratory_system2.16556441
12MP0005451_abnormal_body_composition2.06295624
13MP0000678_abnormal_parathyroid_gland2.03405348
14MP0005410_abnormal_fertilization15.7049515
15MP0005645_abnormal_hypothalamus_physiol1.89257332
16MP0002160_abnormal_reproductive_system1.87891897
17MP0001348_abnormal_lacrimal_gland1.81689084
18MP0009697_abnormal_copulation1.66383384
19MP0005623_abnormal_meninges_morphology1.58198740
20MP0003646_muscle_fatigue1.57561140
21MP0008057_abnormal_DNA_replication1.47052357
22MP0002822_catalepsy1.42080434
23MP0005379_endocrine/exocrine_gland_phen1.35685764
24MP0001485_abnormal_pinna_reflex1.30102193
25MP0001968_abnormal_touch/_nociception1.27923739
26MP0002282_abnormal_trachea_morphology1.22329369
27MP0008058_abnormal_DNA_repair1.21692250
28MP0001486_abnormal_startle_reflex1.19721223
29MP0004233_abnormal_muscle_weight1.18673142
30MP0005423_abnormal_somatic_nervous1.18075977
31MP0005310_abnormal_salivary_gland1.12909606
32MP0005395_other_phenotype1.12767471
33MP0010094_abnormal_chromosome_stability1.09493426
34MP0005647_abnormal_sex_gland1.07515442
35MP0008995_early_reproductive_senescence1.05918608
36MP0001905_abnormal_dopamine_level1.03000097
37MP0001765_abnormal_ion_homeostasis1.00209472
38MP0001984_abnormal_olfaction0.97242355
39MP0006292_abnormal_olfactory_placode0.96818447
40MP0000681_abnormal_thyroid_gland0.95588493
41MP0003656_abnormal_erythrocyte_physiolo0.94495260
42MP0005389_reproductive_system_phenotype0.94100026
43MP0004742_abnormal_vestibular_system0.93709323
44MP0005084_abnormal_gallbladder_morpholo0.91795396
45MP0001963_abnormal_hearing_physiology0.91479306
46MP0008789_abnormal_olfactory_epithelium0.91409383
47MP0002229_neurodegeneration0.88766844
48MP0003011_delayed_dark_adaptation0.87628649
49MP0002138_abnormal_hepatobiliary_system0.87297858
50MP0002249_abnormal_larynx_morphology0.84959797
51MP0008007_abnormal_cellular_replicative0.81068969
52MP0002735_abnormal_chemical_nociception0.79346896
53MP0002127_abnormal_cardiovascular_syste0.77521502
54MP0003786_premature_aging0.76723069
55MP0002234_abnormal_pharynx_morphology0.73812335
56MP0005083_abnormal_biliary_tract0.72793098
57MP0000569_abnormal_digit_pigmentation0.72597701
58MP0006276_abnormal_autonomic_nervous0.71646398
59MP0003880_abnormal_central_pattern0.70802671
60MP0009046_muscle_twitch0.69420016
61MP0001545_abnormal_hematopoietic_system0.67797947
62MP0005397_hematopoietic_system_phenotyp0.67797947
63MP0003111_abnormal_nucleus_morphology0.67269753
64MP0000015_abnormal_ear_pigmentation0.67094930
65MP0002067_abnormal_sensory_capabilities0.67030147
66MP0005535_abnormal_body_temperature0.66770688
67MP0002733_abnormal_thermal_nociception0.66322372
68MP0005377_hearing/vestibular/ear_phenot0.66038773
69MP0003878_abnormal_ear_physiology0.66038773
70MP0003115_abnormal_respiratory_system0.65561566
71MP0000955_abnormal_spinal_cord0.65464058
72MP0000358_abnormal_cell_content/0.62756239
73MP0004085_abnormal_heartbeat0.62294628
74MP0009278_abnormal_bone_marrow0.62244709
75MP0000026_abnormal_inner_ear0.61694310
76MP0005394_taste/olfaction_phenotype0.59759421
77MP0005499_abnormal_olfactory_system0.59759421
78MP0009764_decreased_sensitivity_to0.56499839
79MP0005636_abnormal_mineral_homeostasis0.56468485
80MP0002557_abnormal_social/conspecific_i0.55136095
81MP0003699_abnormal_female_reproductive0.54118243
82MP0005666_abnormal_adipose_tissue0.53516314
83MP0004808_abnormal_hematopoietic_stem0.53410407
84MP0003329_amyloid_beta_deposits0.49929957
85MP0001873_stomach_inflammation0.48583203
86MP0001730_embryonic_growth_arrest0.48042607
87MP0001764_abnormal_homeostasis0.47468350
88MP0004859_abnormal_synaptic_plasticity0.47204147
89MP0001529_abnormal_vocalization0.46877350
90MP0002928_abnormal_bile_duct0.46079359
91MP0005646_abnormal_pituitary_gland0.44842489
92MP0005266_abnormal_metabolism0.44738477
93MP0003950_abnormal_plasma_membrane0.44444734
94MP0000372_irregular_coat_pigmentation0.43859190
95MP0004484_altered_response_of0.43591838
96MP0005167_abnormal_blood-brain_barrier0.43149141
97MP0001293_anophthalmia0.42955186
98MP0001119_abnormal_female_reproductive0.42731355
99MP0010307_abnormal_tumor_latency0.42527954
100MP0006036_abnormal_mitochondrial_physio0.42238651
101MP0002272_abnormal_nervous_system0.41808178
102MP0004036_abnormal_muscle_relaxation0.41518029
103MP0001501_abnormal_sleep_pattern0.40739365
104MP0000003_abnormal_adipose_tissue0.40712251
105MP0001324_abnormal_eye_pigmentation0.40698848
106MP0003077_abnormal_cell_cycle0.40471059
107MP0002269_muscular_atrophy0.40064623
108MP0001270_distended_abdomen0.38524417
109MP0002572_abnormal_emotion/affect_behav0.38440954
110MP0002837_dystrophic_cardiac_calcinosis0.38433591
111MP0004134_abnormal_chest_morphology0.36119448
112MP0005464_abnormal_platelet_physiology0.35876704
113MP0009115_abnormal_fat_cell0.33507037
114MP0005253_abnormal_eye_physiology0.32438207
115MP0001727_abnormal_embryo_implantation0.31024433
116MP0005391_vision/eye_phenotype0.30524662
117MP0000313_abnormal_cell_death0.30410994
118MP0002971_abnormal_brown_adipose0.30090569
119MP0002139_abnormal_hepatobiliary_system0.29481120
120MP0000534_abnormal_ureter_morphology0.25852240
121MP0005551_abnormal_eye_electrophysiolog0.25760925
122MP0000604_amyloidosis0.25760532
123MP0003879_abnormal_hair_cell0.24216344
124MP0004019_abnormal_vitamin_homeostasis0.23457962
125MP0003861_abnormal_nervous_system0.23274162
126MP0002084_abnormal_developmental_patter0.23157852
127MP0008961_abnormal_basal_metabolism0.22052816
128MP0002092_abnormal_eye_morphology0.21926420
129MP0003942_abnormal_urinary_system0.21918390
130MP0001661_extended_life_span0.21400857
131MP0005380_embryogenesis_phenotype0.21323012
132MP0001672_abnormal_embryogenesis/_devel0.21323012
133MP0005365_abnormal_bile_salt0.21009502
134MP0006035_abnormal_mitochondrial_morpho0.20550529
135MP0001697_abnormal_embryo_size0.20177139
136MP0004133_heterotaxia0.19796400
137MP0004811_abnormal_neuron_physiology0.19262423
138MP0002169_no_abnormal_phenotype0.18824781
139MP0002873_normal_phenotype0.18541398
140MP0001849_ear_inflammation0.18248681
141MP0001851_eye_inflammation0.18209414
142MP0002152_abnormal_brain_morphology0.17789367
143MP0002405_respiratory_system_inflammati0.17629083
144MP0003693_abnormal_embryo_hatching0.17494756
145MP0002080_prenatal_lethality0.17281793
146MP0003045_fibrosis0.16356355
147MP0000751_myopathy0.15791312
148MP0003948_abnormal_gas_homeostasis0.15629277
149MP0003633_abnormal_nervous_system0.15278283
150MP0003984_embryonic_growth_retardation0.15080126
151MP0002736_abnormal_nociception_after0.14714448
152MP0005375_adipose_tissue_phenotype0.14612416
153MP0002970_abnormal_white_adipose0.13494301
154MP0003936_abnormal_reproductive_system0.13416788
155MP0000001_mammalian_phenotype0.13372641
156MP0003631_nervous_system_phenotype0.13219689
157MP0002088_abnormal_embryonic_growth/wei0.13108977

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.28302220
2Abnormal respiratory motile cilium morphology (HP:0005938)8.93662422
3Abnormal respiratory epithelium morphology (HP:0012253)8.93662422
4Rhinitis (HP:0012384)7.80366678
5Severe visual impairment (HP:0001141)7.46406180
6Chronic bronchitis (HP:0004469)7.33715688
7Abnormal ciliary motility (HP:0012262)7.24948904
8Infertility (HP:0000789)6.82534087
9Nasal polyposis (HP:0100582)6.53937249
10Abnormality of the nasal mucosa (HP:0000433)5.38311191
11Attenuation of retinal blood vessels (HP:0007843)4.82439520
12Chronic hepatic failure (HP:0100626)4.82083939
13Bronchitis (HP:0012387)4.62877772
14Bronchiectasis (HP:0002110)4.60773969
15Nephronophthisis (HP:0000090)4.51035065
16Abnormal rod and cone electroretinograms (HP:0008323)4.34588534
17Bony spicule pigmentary retinopathy (HP:0007737)4.25470417
18Male infertility (HP:0003251)4.17944596
19Asymmetric septal hypertrophy (HP:0001670)4.12109231
20Abnormality of macular pigmentation (HP:0008002)3.99098119
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.92764698
22Resting tremor (HP:0002322)3.89936259
23Hyperkalemia (HP:0002153)3.85739716
24Aplasia/Hypoplasia of the earlobes (HP:0009906)3.70936078
25Abnormal spermatogenesis (HP:0008669)3.44565649
26Abnormality of the renal medulla (HP:0100957)3.41854425
27Recurrent otitis media (HP:0000403)3.35347402
28Hypoplasia of the thymus (HP:0000778)3.32167458
29Abnormality of the lower motor neuron (HP:0002366)3.31223131
30Cone-rod dystrophy (HP:0000548)3.30318521
31Recurrent sinusitis (HP:0011108)3.26680629
32Facial shape deformation (HP:0011334)3.20771087
33Potter facies (HP:0002009)3.20771087
34Gonadotropin excess (HP:0000837)3.14018728
35Generalized aminoaciduria (HP:0002909)3.03839188
36Postural instability (HP:0002172)2.97844571
37Tubulointerstitial nephritis (HP:0001970)2.95609481
38Abnormality of dental color (HP:0011073)2.86439536
39Recurrent bronchitis (HP:0002837)2.82319161
40Amelogenesis imperfecta (HP:0000705)2.77314733
41Tubular atrophy (HP:0000092)2.71817866
42Abnormality of the parathyroid morphology (HP:0011766)2.70357328
43Amyotrophic lateral sclerosis (HP:0007354)2.64124265
44Abnormality of midbrain morphology (HP:0002418)2.62941678
45Molar tooth sign on MRI (HP:0002419)2.62941678
46Impulsivity (HP:0100710)2.60691217
47Tubulointerstitial abnormality (HP:0001969)2.56879927
48Truncal obesity (HP:0001956)2.47201845
49Azoospermia (HP:0000027)2.42871241
50Renal Fanconi syndrome (HP:0001994)2.40416461
51Menstrual irregularities (HP:0000858)2.36464439
52Hypoalphalipoproteinemia (HP:0003233)2.35581373
53Unilateral renal agenesis (HP:0000122)2.35545664
54Fibular hypoplasia (HP:0003038)2.34846447
55Medial flaring of the eyebrow (HP:0010747)2.33942348
56Rhabdomyolysis (HP:0003201)2.32879080
57Progressive cerebellar ataxia (HP:0002073)2.29820608
58Portal hypertension (HP:0001409)2.29272040
59Insulin-resistant diabetes mellitus (HP:0000831)2.27312234
60Hypoplastic ischia (HP:0003175)2.25297260
61Renovascular hypertension (HP:0100817)2.23898035
62Abnormality of potassium homeostasis (HP:0011042)2.22123754
63Enlarged epiphyses (HP:0010580)2.19852198
64Congenital malformation of the right heart (HP:0011723)2.16666110
65Double outlet right ventricle (HP:0001719)2.16666110
66Occipital encephalocele (HP:0002085)2.14094417
67Tubulointerstitial fibrosis (HP:0005576)2.10144592
68Impaired proprioception (HP:0010831)2.09721601
69Hyperthyroidism (HP:0000836)2.07493572
70Abnormal gallbladder physiology (HP:0012438)2.07187820
71Cholecystitis (HP:0001082)2.07187820
72Abnormality of the hepatic vasculature (HP:0006707)2.07161208
73Abnormality of the aortic arch (HP:0012303)2.05458933
74Postaxial foot polydactyly (HP:0001830)2.03512176
75Failure to thrive in infancy (HP:0001531)2.01713398
76Tetany (HP:0001281)2.01621343
77Hypoplasia of the capital femoral epiphysis (HP:0003090)2.00583369
78Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2260176
79Dynein arm defect of respiratory motile cilia (HP:0012255)12.8329163
80Absent/shortened dynein arms (HP:0200106)12.8329163
81Aplasia/Hypoplasia of the thymus (HP:0010515)1.98792253
82Stage 5 chronic kidney disease (HP:0003774)1.96899137
83Progressive sensorineural hearing impairment (HP:0000408)1.93850096
84Hypoparathyroidism (HP:0000829)1.90262328
85Upper motor neuron abnormality (HP:0002127)1.89535289
86Spastic paraparesis (HP:0002313)1.88788393
87Abnormal drinking behavior (HP:0030082)1.88520591
88Polydipsia (HP:0001959)1.88520591
89Pancreatic cysts (HP:0001737)1.88307572
90Myoglobinuria (HP:0002913)1.87989258
91Abnormality of urine glucose concentration (HP:0011016)1.87006487
92Glycosuria (HP:0003076)1.87006487
93Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86099800
94Recurrent pneumonia (HP:0006532)1.84976465
95Abnormality of the renal cortex (HP:0011035)1.84340830
96Congenital hepatic fibrosis (HP:0002612)1.84331044
97Spastic tetraparesis (HP:0001285)1.83589697
98Photophobia (HP:0000613)1.82939466
99Short ribs (HP:0000773)1.81834120
100Abnormality of the ischium (HP:0003174)1.80429876
101Degeneration of anterior horn cells (HP:0002398)1.80195666
102Abnormality of the anterior horn cell (HP:0006802)1.80195666
103Oculomotor apraxia (HP:0000657)1.79045071
104Abnormality of the heme biosynthetic pathway (HP:0010472)1.78429645
105Muscle fiber atrophy (HP:0100295)1.73880429
106Optic nerve hypoplasia (HP:0000609)1.72947256
107Abnormality of the costochondral junction (HP:0000919)1.72708390
108Type II diabetes mellitus (HP:0005978)1.72561337
109Type II lissencephaly (HP:0007260)1.72123210
110Retinal dysplasia (HP:0007973)1.69513097
111Abnormality of dentin (HP:0010299)1.67768980
112Heterotopia (HP:0002282)1.67201417
113Hyperuricemia (HP:0002149)1.66983068
114Increased purine levels (HP:0004368)1.66983068
115Abnormality of renal resorption (HP:0011038)1.66755070
116Hypophosphatemic rickets (HP:0004912)1.66734772
117Renal dysplasia (HP:0000110)1.66154622
118Aplasia/Hypoplasia of the sacrum (HP:0008517)1.64713725
119Dyschromatopsia (HP:0007641)1.64180247
120Seborrheic dermatitis (HP:0001051)1.62073443
121Absent frontal sinuses (HP:0002688)1.60956819
122Hyponatremia (HP:0002902)1.59793338
123Abnormality of renal excretion (HP:0011036)1.58545531
124Abnormal biliary tract physiology (HP:0012439)1.57711873
125Bile duct proliferation (HP:0001408)1.57711873
126Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.57423864
127Absent epiphyses (HP:0010577)1.57423864
128Facial cleft (HP:0002006)1.56457631
129Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.55527529
130Abnormality of permanent molar morphology (HP:0011071)1.55517366
131Abnormality of the dental root (HP:0006486)1.55517366
132Taurodontia (HP:0000679)1.55517366
133Bell-shaped thorax (HP:0001591)1.53146816
134J-shaped sella turcica (HP:0002680)1.52197113
135Supernumerary spleens (HP:0009799)1.51403792
136Postaxial hand polydactyly (HP:0001162)1.50180403
137Chronic sinusitis (HP:0011109)1.49421706
138Deformed sella turcica (HP:0002681)1.46605413
139Microglossia (HP:0000171)1.44793719
140Abnormality of molar morphology (HP:0011070)1.42678301
141Abnormality of molar (HP:0011077)1.42678301
142Broad distal phalanx of finger (HP:0009836)1.42101515
143Abnormality of the dental pulp (HP:0006479)1.42085281
144Aplasia/Hypoplasia of the fibula (HP:0006492)1.42022310
145Choroideremia (HP:0001139)1.41588862
146Short thorax (HP:0010306)1.39544346
147Cystic liver disease (HP:0006706)1.39103881
148Decreased central vision (HP:0007663)1.37839332
14911 pairs of ribs (HP:0000878)1.33929929
150Abnormal urine output (HP:0012590)1.33584381
151Hemorrhage of the eye (HP:0011885)1.31008550
152Median cleft lip (HP:0000161)1.30903902
153Nephropathy (HP:0000112)1.30474337
154Cerebellar dysplasia (HP:0007033)1.28850150
155Abnormality of ocular smooth pursuit (HP:0000617)1.25130880
156Aplasia/Hypoplasia of the lens (HP:0008063)1.24482599
157Short femoral neck (HP:0100864)1.23963215
158Neurofibrillary tangles (HP:0002185)1.23192874
159Aplasia/Hypoplasia of the tongue (HP:0010295)1.22632463
160Easy fatigability (HP:0003388)1.21062465
161Pachygyria (HP:0001302)1.19024128
162Exercise-induced myalgia (HP:0003738)1.18755961
163Polyuria (HP:0000103)1.18105962
164Conjunctival telangiectasia (HP:0000524)1.17277165
165Pancreatic fibrosis (HP:0100732)1.17033529
166Decreased motor nerve conduction velocity (HP:0003431)1.16554251
167Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.15504378

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.66646344
2PDK38.66646344
3PDK25.60202253
4TESK15.42874063
5PRKD34.38463065
6ICK3.96324675
7MAP4K23.74564807
8INSRR3.38006644
9PLK22.76369328
10BRD42.75680521
11DDR22.73720413
12MAP3K112.55088219
13PTK2B2.41330597
14WNK42.30594403
15PNCK2.22749268
16STK392.15634628
17NEK22.01660865
18PIK3CG1.89146980
19STK381.55570448
20ZAK1.43865505
21VRK21.33265643
22CDK71.32849928
23DYRK1B1.32215466
24TAOK31.18989235
25NUAK11.12087900
26MAPK151.07836063
27PIM21.05365156
28VRK11.04314188
29PDK11.01731879
30WNK10.99306083
31TYRO30.93113335
32CDC70.90117083
33CCNB10.89498597
34PASK0.88628720
35STK30.86365805
36DYRK30.86005295
37MAP2K20.83971420
38SIK20.78397529
39ARAF0.76811680
40TTK0.74450112
41AKT30.74023119
42BCKDK0.73906179
43LATS10.67009547
44MST1R0.66092587
45EEF2K0.65931653
46PINK10.62904908
47MAP3K10.60383796
48IRAK10.59505395
49KDR0.59303787
50WEE10.58534736
51KIT0.56100672
52CHEK20.53453496
53DYRK20.52219078
54FRK0.52094775
55CAMK1G0.51410146
56TESK20.51219815
57PRKAA20.50764877
58CHEK10.50415972
59TNK20.49737055
60ADRBK20.49396119
61PDPK10.49361180
62ATR0.49127096
63RPS6KA50.42309936
64UHMK10.41409013
65CAMK10.41284036
66TEC0.40754977
67IKBKB0.40051304
68SRPK10.39052163
69MAPK10.38434757
70MAP2K70.37231101
71JAK30.36538716
72MUSK0.35485993
73STK38L0.35450298
74ATM0.35412804
75TLK10.35268924
76MAP2K60.34840862
77BTK0.34201184
78MAP3K80.33914913
79PAK10.33464508
80RIPK40.32712293
81TXK0.32307797
82NTRK20.32041242
83PLK40.31845262
84CDK90.31271041
85PKN10.31206622
86SYK0.30432952
87LMTK20.29821802
88MTOR0.29715878
89MAPK130.27764380
90PAK20.26096078
91PLK10.25995335
92GRK60.24909793
93PRKCG0.24760855
94KSR20.23198822
95FLT30.23018713
96MAP3K100.22898446
97CAMK40.22564997
98TAF10.22464313
99MAPK110.22279494
100MAPKAPK50.20806366
101CDK120.20163953
102PRKAA10.20157753
103MINK10.20077433
104AKT10.19927213
105CAMKK10.19581767
106MAPK140.19517819
107PAK40.18732855
108MARK20.18510499
109IRAK20.18181427
110RPS6KB10.17683743
111BRSK20.16959975
112BMPR1B0.13631487
113STK100.10877191
114BRAF0.10849078
115BUB10.09174292
116WNK30.09124512
117CSF1R0.09064513
118PRKCZ0.08996158
119PRKCQ0.07808552
120CSNK2A10.07485712
121NEK60.06943201
122BRSK10.06541313
123CDK150.06016928
124CDK20.05955252
125CDK10.05923938
126RPS6KA10.04903221
127GSK3B0.04503765
128MARK30.04339625
129CDK180.03672116
130CDK11A0.03566372
131CDK40.03210913
132ZAP700.03118120
133CSNK1D0.03102834
134MAPK80.02218484
135CSNK2A20.00979904
136PIM10.00624262
137PRKDC0.00193290
138AURKA0.00174600
139CSK-0.0335331
140MAP4K1-0.0321255
141CDK3-0.0321221
142EGFR-0.0265775
143PRKG1-0.0142608
144PRKG2-0.0130650
145PRKACB-0.0128974
146PRKCB-0.0128858
147CLK1-0.0121219
148STK11-0.0114085
149MAP3K4-0.0113171
150TAOK1-0.0087245
151CDK14-0.0082313
152TRIB3-0.0064091
153PAK6-0.0054318
154CDK6-0.0007541
155PRKACG-0.0004874

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.96654885
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.52461035
3Vitamin B6 metabolism_Homo sapiens_hsa007504.28676086
4Pyruvate metabolism_Homo sapiens_hsa006204.08256652
5Fatty acid biosynthesis_Homo sapiens_hsa000613.90521592
6Olfactory transduction_Homo sapiens_hsa047403.59064817
7Butanoate metabolism_Homo sapiens_hsa006503.43750801
8Propanoate metabolism_Homo sapiens_hsa006403.07897407
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.90692293
10Glucagon signaling pathway_Homo sapiens_hsa049222.80979323
11Linoleic acid metabolism_Homo sapiens_hsa005912.80025170
12Basal transcription factors_Homo sapiens_hsa030222.67741888
13Selenocompound metabolism_Homo sapiens_hsa004502.61228339
14Dorso-ventral axis formation_Homo sapiens_hsa043202.31546834
15Fanconi anemia pathway_Homo sapiens_hsa034602.10537676
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.07761865
17Pentose phosphate pathway_Homo sapiens_hsa000302.06254483
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.02283126
19Carbohydrate digestion and absorption_Homo sapiens_hsa049732.01162268
20Phototransduction_Homo sapiens_hsa047441.99552381
21Glycerolipid metabolism_Homo sapiens_hsa005611.95364108
22Oocyte meiosis_Homo sapiens_hsa041141.86881318
23Base excision repair_Homo sapiens_hsa034101.86227969
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.79202859
25PPAR signaling pathway_Homo sapiens_hsa033201.71636107
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.58096261
27Fructose and mannose metabolism_Homo sapiens_hsa000511.56961072
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.55066117
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.54045290
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51779450
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.47723642
32Carbon metabolism_Homo sapiens_hsa012001.44850904
33Antigen processing and presentation_Homo sapiens_hsa046121.40729461
34Amphetamine addiction_Homo sapiens_hsa050311.40693267
35Phenylalanine metabolism_Homo sapiens_hsa003601.39378046
36Huntingtons disease_Homo sapiens_hsa050161.37453692
37mRNA surveillance pathway_Homo sapiens_hsa030151.36524917
38Taste transduction_Homo sapiens_hsa047421.35662393
39Fat digestion and absorption_Homo sapiens_hsa049751.35577846
40Type I diabetes mellitus_Homo sapiens_hsa049401.30388339
41RNA transport_Homo sapiens_hsa030131.28847548
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26870151
43Fatty acid degradation_Homo sapiens_hsa000711.25331318
44Fatty acid metabolism_Homo sapiens_hsa012121.24891781
45Ether lipid metabolism_Homo sapiens_hsa005651.20469955
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.14418820
47Allograft rejection_Homo sapiens_hsa053301.12453595
48Autoimmune thyroid disease_Homo sapiens_hsa053201.10190834
49Peroxisome_Homo sapiens_hsa041461.09765303
50Cardiac muscle contraction_Homo sapiens_hsa042601.09482491
51Renin secretion_Homo sapiens_hsa049241.07502897
52Mineral absorption_Homo sapiens_hsa049781.04140150
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01741532
54Purine metabolism_Homo sapiens_hsa002301.01533274
55Non-homologous end-joining_Homo sapiens_hsa034501.00286993
56Biosynthesis of amino acids_Homo sapiens_hsa012300.94756039
57Type II diabetes mellitus_Homo sapiens_hsa049300.92952373
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92465086
59Primary immunodeficiency_Homo sapiens_hsa053400.91907249
60Graft-versus-host disease_Homo sapiens_hsa053320.91018992
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89959934
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.89434616
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.88530649
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88092820
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86949679
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86554807
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84844601
68Arginine and proline metabolism_Homo sapiens_hsa003300.81199951
69Glutathione metabolism_Homo sapiens_hsa004800.79833276
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79505673
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77568251
72ABC transporters_Homo sapiens_hsa020100.77391109
73Nitrogen metabolism_Homo sapiens_hsa009100.75887766
74Sulfur relay system_Homo sapiens_hsa041220.73509358
75Chemical carcinogenesis_Homo sapiens_hsa052040.72185835
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71446376
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71365002
78Legionellosis_Homo sapiens_hsa051340.71164314
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.70408540
80Tyrosine metabolism_Homo sapiens_hsa003500.70344276
81Estrogen signaling pathway_Homo sapiens_hsa049150.70161783
82Long-term potentiation_Homo sapiens_hsa047200.69870425
83Arachidonic acid metabolism_Homo sapiens_hsa005900.66127303
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.65810602
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64867732
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64160051
87Hedgehog signaling pathway_Homo sapiens_hsa043400.62846161
88Arginine biosynthesis_Homo sapiens_hsa002200.61477480
89Acute myeloid leukemia_Homo sapiens_hsa052210.60584175
90Regulation of autophagy_Homo sapiens_hsa041400.59292436
91Synaptic vesicle cycle_Homo sapiens_hsa047210.59291893
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56424435
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56333856
94RNA polymerase_Homo sapiens_hsa030200.55837707
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53282699
96Viral myocarditis_Homo sapiens_hsa054160.52014558
97VEGF signaling pathway_Homo sapiens_hsa043700.51660026
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.49432832
99Herpes simplex infection_Homo sapiens_hsa051680.47956920
100Bile secretion_Homo sapiens_hsa049760.47177801
101AMPK signaling pathway_Homo sapiens_hsa041520.47063406
102Systemic lupus erythematosus_Homo sapiens_hsa053220.46538415
103Pyrimidine metabolism_Homo sapiens_hsa002400.45922721
104Thyroid hormone synthesis_Homo sapiens_hsa049180.44249478
105Nucleotide excision repair_Homo sapiens_hsa034200.43481607
106Collecting duct acid secretion_Homo sapiens_hsa049660.41487401
107Endocytosis_Homo sapiens_hsa041440.40545784
108Insulin secretion_Homo sapiens_hsa049110.40338078
109RNA degradation_Homo sapiens_hsa030180.39715594
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38408833
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37818914
112Calcium signaling pathway_Homo sapiens_hsa040200.35839939
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35622690
114One carbon pool by folate_Homo sapiens_hsa006700.35262529
115N-Glycan biosynthesis_Homo sapiens_hsa005100.35107904
116Renin-angiotensin system_Homo sapiens_hsa046140.34638789
117Metabolic pathways_Homo sapiens_hsa011000.34433728
118Influenza A_Homo sapiens_hsa051640.34151891
119Homologous recombination_Homo sapiens_hsa034400.33801338
120Cell cycle_Homo sapiens_hsa041100.32983900
121Spliceosome_Homo sapiens_hsa030400.32923425
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31443039
123B cell receptor signaling pathway_Homo sapiens_hsa046620.30527389
124Parkinsons disease_Homo sapiens_hsa050120.29644703
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.28856628
126Morphine addiction_Homo sapiens_hsa050320.28731140
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28473408
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.27644065
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27503342
130Mismatch repair_Homo sapiens_hsa034300.27254018
131Pancreatic secretion_Homo sapiens_hsa049720.26982300
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26887977
133DNA replication_Homo sapiens_hsa030300.26213584
134Inositol phosphate metabolism_Homo sapiens_hsa005620.25988387
135Protein digestion and absorption_Homo sapiens_hsa049740.22667797
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21967307
137Viral carcinogenesis_Homo sapiens_hsa052030.18203830
138Alcoholism_Homo sapiens_hsa050340.17263480
139Retinol metabolism_Homo sapiens_hsa008300.13025219
140Epstein-Barr virus infection_Homo sapiens_hsa051690.12860365
141Salivary secretion_Homo sapiens_hsa049700.11400733
142Wnt signaling pathway_Homo sapiens_hsa043100.11043154
143cAMP signaling pathway_Homo sapiens_hsa040240.10707832
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.10482155
145HIF-1 signaling pathway_Homo sapiens_hsa040660.10393455
146Salmonella infection_Homo sapiens_hsa051320.10059158
147Gastric acid secretion_Homo sapiens_hsa049710.08232579

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