PHF8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this gene are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD). Four transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of telomere maintenance via telomerase (GO:0032210)9.10454326
2chromosome organization involved in meiosis (GO:0070192)9.08715066
3piRNA metabolic process (GO:0034587)9.07441121
4synaptonemal complex assembly (GO:0007130)8.81916432
5male meiosis I (GO:0007141)8.28682299
6DNA methylation involved in gamete generation (GO:0043046)8.07104383
7DNA synthesis involved in DNA repair (GO:0000731)7.75864479
8synaptonemal complex organization (GO:0070193)7.69809730
9male meiosis (GO:0007140)7.16966668
10meiotic nuclear division (GO:0007126)6.68096951
11meiosis I (GO:0007127)6.67468542
12sister chromatid cohesion (GO:0007062)6.00221461
13meiotic chromosome segregation (GO:0045132)5.37103875
14meiotic cell cycle process (GO:1903046)5.18936261
15regulation of telomere maintenance (GO:0032204)5.04587750
16mitotic sister chromatid cohesion (GO:0007064)4.98622636
17regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.86557171
18maturation of 5.8S rRNA (GO:0000460)4.75814366
19gene silencing by RNA (GO:0031047)4.74261623
20regulation of NFAT protein import into nucleus (GO:0051532)4.65040039
21regulation of RNA export from nucleus (GO:0046831)4.54637216
22mitotic chromosome condensation (GO:0007076)4.51547834
23positive regulation of dendrite morphogenesis (GO:0050775)4.44574576
24DNA alkylation (GO:0006305)4.36007627
25DNA methylation (GO:0006306)4.36007627
26signal complex assembly (GO:0007172)4.32022657
27positive regulation of microtubule polymerization (GO:0031116)4.17666756
28embryonic process involved in female pregnancy (GO:0060136)4.09383495
29regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.09108327
30histone H3-K4 trimethylation (GO:0080182)4.02095103
31membrane assembly (GO:0071709)4.01368423
32regulation of short-term neuronal synaptic plasticity (GO:0048172)4.00022854
33mannosylation (GO:0097502)3.87669440
34negative regulation of exocytosis (GO:0045920)3.74405304
35regulation of nucleobase-containing compound transport (GO:0032239)3.71727458
36positive regulation of pseudopodium assembly (GO:0031274)3.68180981
37natural killer cell activation involved in immune response (GO:0002323)3.65656671
38positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.61696834
39regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.61696834
40regulation of RIG-I signaling pathway (GO:0039535)3.60786284
41embryonic camera-type eye morphogenesis (GO:0048596)3.60046529
42female gamete generation (GO:0007292)3.57398932
43nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.56679668
44reciprocal meiotic recombination (GO:0007131)3.54140316
45reciprocal DNA recombination (GO:0035825)3.54140316
46gene silencing (GO:0016458)3.52637439
47genitalia morphogenesis (GO:0035112)3.52282268
48binding of sperm to zona pellucida (GO:0007339)3.46973717
49regulation of DNA endoreduplication (GO:0032875)3.44165031
50growth hormone receptor signaling pathway (GO:0060396)3.38552792
51histone H4-K12 acetylation (GO:0043983)3.36506743
52protein ADP-ribosylation (GO:0006471)3.36431755
53negative regulation of histone methylation (GO:0031061)3.35667978
54positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.33646194
55positive regulation of response to oxidative stress (GO:1902884)3.33228285
56positive regulation of cellular response to oxidative stress (GO:1900409)3.33228285
57negative regulation of DNA repair (GO:0045738)3.32236204
58histone H3-K4 methylation (GO:0051568)3.29945536
59RNA destabilization (GO:0050779)3.22158749
60regulation of pseudopodium assembly (GO:0031272)3.19483918
61regulation of histone methylation (GO:0031060)3.19479398
62interkinetic nuclear migration (GO:0022027)3.18217612
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.18048541
64histone H4-K16 acetylation (GO:0043984)3.16742692
65protein localization to chromosome (GO:0034502)3.16674525
66* histone H3-K36 demethylation (GO:0070544)3.15160731
67regulation of meiosis I (GO:0060631)3.14617702
68meiotic cell cycle (GO:0051321)3.12378888
69histone H4 deacetylation (GO:0070933)3.09939045
70cGMP biosynthetic process (GO:0006182)3.05571317
71histone deubiquitination (GO:0016578)3.03625089
72poly(A)+ mRNA export from nucleus (GO:0016973)3.03610525
73regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.03191304
74resolution of meiotic recombination intermediates (GO:0000712)3.03098462
75* histone lysine demethylation (GO:0070076)3.02602141
76DNA packaging (GO:0006323)3.01705059
77oocyte development (GO:0048599)3.01388966
78establishment of nucleus localization (GO:0040023)3.01092053
79regulation of acrosome reaction (GO:0060046)2.99733014
80peptidyl-threonine phosphorylation (GO:0018107)2.99403579
81negative regulation of synaptic transmission, GABAergic (GO:0032229)2.99108275
82negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98809713
83* histone demethylation (GO:0016577)2.98568159
84embryonic body morphogenesis (GO:0010172)2.93280485
85cellular response to growth hormone stimulus (GO:0071378)2.91235048
86positive regulation of humoral immune response (GO:0002922)2.89313356
87* histone H3-K9 demethylation (GO:0033169)2.88416005
88negative regulation of inclusion body assembly (GO:0090084)2.88309956
89DNA methylation or demethylation (GO:0044728)2.87232312
90protein kinase C signaling (GO:0070528)2.86810434
91peptidyl-lysine dimethylation (GO:0018027)2.85014828
92peptidyl-threonine modification (GO:0018210)2.81085075
93positive regulation of synapse assembly (GO:0051965)2.80799036
94positive regulation of histone methylation (GO:0031062)2.79916179
95positive regulation of cGMP biosynthetic process (GO:0030828)2.79137490
96regulation of chromatin binding (GO:0035561)2.78860402
97regulation of MHC class I biosynthetic process (GO:0045343)2.77032382
98body morphogenesis (GO:0010171)2.76966848
99* regulation of chromatin silencing (GO:0031935)2.76914582
100positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.76881454
101nuclear pore complex assembly (GO:0051292)2.73037867
102spindle assembly (GO:0051225)2.70954958
103glucocorticoid receptor signaling pathway (GO:0042921)2.70875968
104chromosome organization (GO:0051276)2.69256792
105mitotic spindle organization (GO:0007052)2.69042325
106DNA biosynthetic process (GO:0071897)2.68912653
107positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.68716795
108heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.68544352
109spindle assembly involved in mitosis (GO:0090307)2.67652956
110nucleus localization (GO:0051647)2.65494473
111chromosome condensation (GO:0030261)2.65186253
112* positive regulation of gene expression, epigenetic (GO:0045815)2.64842598
113fertilization (GO:0009566)2.64219217
114regulation of histone H3-K27 methylation (GO:0061085)2.62812690
115protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.61767790
116positive regulation of gamma-delta T cell activation (GO:0046645)2.61735610
117attachment of spindle microtubules to kinetochore (GO:0008608)2.61660840
118definitive hemopoiesis (GO:0060216)2.61182993
119positive regulation by host of viral transcription (GO:0043923)2.60787126
120sex differentiation (GO:0007548)2.60393692
121* protein dealkylation (GO:0008214)2.59551987
122* protein demethylation (GO:0006482)2.59551987
123regulation of protein polyubiquitination (GO:1902914)2.59472918
124pore complex assembly (GO:0046931)2.56399457
125fibroblast migration (GO:0010761)2.55855938
126negative regulation of histone modification (GO:0031057)2.55492742
127histone H4 acetylation (GO:0043967)2.55313315
128histone H4-K8 acetylation (GO:0043982)2.54273415
129histone H4-K5 acetylation (GO:0043981)2.54273415
130negative regulation of granulocyte differentiation (GO:0030853)2.51784443
131membrane disassembly (GO:0030397)2.51625110
132nuclear envelope disassembly (GO:0051081)2.51625110
133mitotic nuclear envelope disassembly (GO:0007077)2.50880559
134positive regulation of cGMP metabolic process (GO:0030825)2.49304787
135negative regulation of reproductive process (GO:2000242)2.47341167
136regulation of cGMP biosynthetic process (GO:0030826)2.47070423
137nuclear pore organization (GO:0006999)2.46901614
138COPII vesicle coating (GO:0048208)2.46482561
139histone H2A acetylation (GO:0043968)2.44526480
140proximal/distal pattern formation (GO:0009954)2.44437804
141coronary vasculature morphogenesis (GO:0060977)2.43145547
142negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.42525267
143mitotic cytokinesis (GO:0000281)2.42468033
144face development (GO:0060324)2.39414267
145embryonic eye morphogenesis (GO:0048048)2.39386699
146mRNA stabilization (GO:0048255)2.38914805
147RNA stabilization (GO:0043489)2.38914805
148peptidyl-lysine trimethylation (GO:0018023)2.38533413
149regulation of histone H3-K9 methylation (GO:0051570)2.35608372
150paraxial mesoderm development (GO:0048339)2.34275992
151phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.34136396
152positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.33448326
153positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.33448326
154positive regulation of mitotic sister chromatid separation (GO:1901970)2.33448326
155regulation of male gonad development (GO:2000018)2.32013851
156negative regulation of phagocytosis (GO:0050765)2.29092235
157ionotropic glutamate receptor signaling pathway (GO:0035235)2.28336381
158microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.27301282
159positive regulation of dendrite development (GO:1900006)2.27192869
160muscle cell cellular homeostasis (GO:0046716)2.25162209
161histone lysine methylation (GO:0034968)2.24545668
162endosome to lysosome transport (GO:0008333)2.24472124
163forebrain neuron differentiation (GO:0021879)2.22664965
164regulation of cGMP metabolic process (GO:0030823)2.21484169
165intracellular estrogen receptor signaling pathway (GO:0030520)2.21411223
166histone acetylation (GO:0016573)2.20849794
167positive regulation of male gonad development (GO:2000020)2.16890592
168nucleus organization (GO:0006997)2.16039132
169protein localization to microtubule cytoskeleton (GO:0072698)2.14882473
170regulation of odontogenesis (GO:0042481)2.14591795
171internal peptidyl-lysine acetylation (GO:0018393)2.12480410
172facial nerve structural organization (GO:0021612)2.12149437
173presynaptic membrane organization (GO:0097090)14.4207586
174presynaptic membrane assembly (GO:0097105)10.2276437
175synapsis (GO:0007129)10.1211987

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.30094598
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.45701242
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.93106942
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.45820578
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.43009825
6GBX2_23144817_ChIP-Seq_PC3_Human3.32994997
7SMAD_19615063_ChIP-ChIP_OVARY_Human3.29508759
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.06244207
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.66432952
10E2F7_22180533_ChIP-Seq_HELA_Human2.62037229
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.55822542
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.27057936
13VDR_21846776_ChIP-Seq_THP-1_Human2.24057537
14* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.22938484
15CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.19112181
16* POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.05838837
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.01723345
18RUNX_20019798_ChIP-Seq_JUKART_Human2.01300051
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00411722
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.94109435
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93677118
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84134404
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84134294
24* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83741857
25ZFX_18555785_ChIP-Seq_MESCs_Mouse1.81134037
26* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79991617
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.77053588
28DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.76672556
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.75300324
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.75300324
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.75300324
32* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74198299
33CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.73725450
34TCF4_18268006_ChIP-ChIP_LS174T_Human1.73532822
35RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.70652555
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.68190830
37KDM2B_26808549_Chip-Seq_DND41_Human1.64887397
38KDM5A_27292631_Chip-Seq_BREAST_Human1.63320213
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61980044
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61702356
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61443928
42MAF_26560356_Chip-Seq_TH2_Human1.59966586
43MAF_26560356_Chip-Seq_TH1_Human1.59765538
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59285257
45* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58696657
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55421972
47FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.55225409
48ISL1_27105846_Chip-Seq_CPCs_Mouse1.49450666
49FUS_26573619_Chip-Seq_HEK293_Human1.49334075
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.47285080
51SMAD4_21799915_ChIP-Seq_A2780_Human1.47100756
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.46770082
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46734510
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46559532
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45058310
56PKCTHETA_26484144_Chip-Seq_BREAST_Human1.43829675
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43190988
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40338649
59TFEB_21752829_ChIP-Seq_HELA_Human1.40298286
60CHD1_26751641_Chip-Seq_LNCaP_Human1.39711033
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35152910
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34959571
63SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34949018
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34065421
65AHR_22903824_ChIP-Seq_MCF-7_Human1.33758802
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.32980447
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31829284
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.31493071
69TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29902004
70CIITA_25753668_ChIP-Seq_RAJI_Human1.28219572
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27816188
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27363913
73SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26899049
74STAT3_23295773_ChIP-Seq_U87_Human1.25893457
75P68_20966046_ChIP-Seq_HELA_Human1.25491177
76TCF4_23295773_ChIP-Seq_U87_Human1.23922890
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23640583
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22748717
79SCL_19346495_ChIP-Seq_HPC-7_Human1.21836376
80CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21029033
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20404341
82* SMC4_20622854_ChIP-Seq_HELA_Human1.19138721
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19069896
84NCOR1_26117541_ChIP-Seq_K562_Human1.19019531
85HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19001269
86VDR_24763502_ChIP-Seq_THP-1_Human1.18641286
87MYB_26560356_Chip-Seq_TH2_Human1.18424793
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17745759
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16766352
90MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.16115056
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13915069
92MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13824300
93AR_21909140_ChIP-Seq_LNCAP_Human1.13758716
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11293256
95KDM2B_26808549_Chip-Seq_K562_Human1.11051677
96RUNX1_27514584_Chip-Seq_MCF-7_Human1.10251330
97IRF8_22096565_ChIP-ChIP_GC-B_Human1.10028365
98* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08660032
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08287171
100E2F1_21310950_ChIP-Seq_MCF-7_Human1.06955061
101P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06460547
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04609358
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04609358
104STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04368327
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04063840
106MYC_22102868_ChIP-Seq_BL_Human1.03601345
107PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03278058
108ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03227287
109RACK7_27058665_Chip-Seq_MCF-7_Human1.03041156
110PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02609308
111PIAS1_25552417_ChIP-Seq_VCAP_Human1.02463612
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01919183
113P300_19829295_ChIP-Seq_ESCs_Human1.00990444
114NANOG_18555785_Chip-Seq_ESCs_Mouse1.00828291
115DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99813042
116EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99179296
117TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98983818
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98111840
119CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97592920
120PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96819297
121* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96364291
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96078050
123SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95916343
124E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94746169
125ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94740123
126* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94540682
127RNF2_27304074_Chip-Seq_NSC_Mouse0.94498527
128TBL1_22424771_ChIP-Seq_293T_Human0.94211892
129Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94016161
130* FOXA2_19822575_ChIP-Seq_HepG2_Human0.92700017
131PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92158188
132ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91665823
133RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91450680
134SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91406584
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91400301
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91308914
137CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89997528
138E2F1_18555785_Chip-Seq_ESCs_Mouse0.89900461
139FLI1_27457419_Chip-Seq_LIVER_Mouse0.88590340
140SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.88008835
141PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87139215
142EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86869530
143NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86215563
144BCOR_27268052_Chip-Seq_Bcells_Human0.86135674
145IGF1R_20145208_ChIP-Seq_DFB_Human0.85787215
146NFYB_21822215_ChIP-Seq_K562_Human0.85416300
147TCF7_22412390_ChIP-Seq_EML_Mouse0.85285422
148PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85051038
149STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85011688
150GATA3_27048872_Chip-Seq_THYMUS_Human0.84906500
151CLOCK_20551151_ChIP-Seq_293T_Human0.84675621
152ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84645106
153PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84540397
154SOX9_26525672_Chip-Seq_HEART_Mouse0.84133232
155BRD4_25478319_ChIP-Seq_HGPS_Human0.83596172
156CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82988137
157TAF15_26573619_Chip-Seq_HEK293_Human0.82700828
158POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.81941085
159MYB_26560356_Chip-Seq_TH1_Human0.80353009
160UTX_26944678_Chip-Seq_JUKART_Human0.80112968
161SMAD3_21741376_ChIP-Seq_EPCs_Human0.80104152
162KDM2B_26808549_Chip-Seq_JURKAT_Human0.80053227
163ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.79303278
164EZH2_22144423_ChIP-Seq_EOC_Human0.79235012
165CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.79024193
166WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79013754
167STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.78855566
168AR_19668381_ChIP-Seq_PC3_Human0.78720350
169OCT4_18555785_Chip-Seq_ESCs_Mouse0.78444531

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.34016484
2MP0008995_early_reproductive_senescence4.61792710
3MP0005171_absent_coat_pigmentation4.59862421
4MP0005248_abnormal_Harderian_gland4.49222473
5MP0010352_gastrointestinal_tract_polyps4.27787456
6MP0001188_hyperpigmentation3.93838867
7MP0002396_abnormal_hematopoietic_system3.23177709
8MP0003300_gastrointestinal_ulcer3.13980008
9MP0009278_abnormal_bone_marrow2.94938386
10MP0001929_abnormal_gametogenesis2.84037744
11MP0005409_darkened_coat_color2.71511571
12MP0003693_abnormal_embryo_hatching2.52541439
13MP0006292_abnormal_olfactory_placode2.49295566
14MP0005451_abnormal_body_composition2.36101265
15MP0000569_abnormal_digit_pigmentation2.31730697
16MP0009379_abnormal_foot_pigmentation2.25949956
17MP0000015_abnormal_ear_pigmentation2.15864396
18MP0004130_abnormal_muscle_cell2.14936313
19MP0004134_abnormal_chest_morphology2.12632419
20MP0003698_abnormal_male_reproductive2.12392566
21MP0005187_abnormal_penis_morphology2.07996471
22MP0000465_gastrointestinal_hemorrhage1.97763612
23MP0003890_abnormal_embryonic-extraembry1.96288810
24MP0003763_abnormal_thymus_physiology1.88924114
25MP0003868_abnormal_feces_composition1.86316322
26MP0003699_abnormal_female_reproductive1.80952477
27MP0008260_abnormal_autophagy1.74011017
28MP0002009_preneoplasia1.70191483
29MP0004147_increased_porphyrin_level1.67707323
30MP0008877_abnormal_DNA_methylation1.65406809
31MP0010234_abnormal_vibrissa_follicle1.64321256
32MP0003119_abnormal_digestive_system1.62833679
33MP0003453_abnormal_keratinocyte_physiol1.62476127
34MP0001915_intracranial_hemorrhage1.61075595
35MP0004233_abnormal_muscle_weight1.60304074
36MP0003123_paternal_imprinting1.59871753
37MP0000383_abnormal_hair_follicle1.59419578
38MP0003787_abnormal_imprinting1.58142042
39MP0010678_abnormal_skin_adnexa1.57942319
40MP0003786_premature_aging1.56015913
41MP0002161_abnormal_fertility/fecundity1.49321534
42MP0003718_maternal_effect1.47829025
43MP0002877_abnormal_melanocyte_morpholog1.39862890
44MP0003111_abnormal_nucleus_morphology1.39166873
45MP0008058_abnormal_DNA_repair1.37286942
46MP0003984_embryonic_growth_retardation1.31587796
47MP0002095_abnormal_skin_pigmentation1.31412035
48MP0003385_abnormal_body_wall1.31046631
49MP0001873_stomach_inflammation1.29475178
50MP0002177_abnormal_outer_ear1.29102284
51MP0005397_hematopoietic_system_phenotyp1.27371266
52MP0001545_abnormal_hematopoietic_system1.27371266
53MP0005076_abnormal_cell_differentiation1.27203099
54MP0003121_genomic_imprinting1.25462655
55MP0002088_abnormal_embryonic_growth/wei1.24855540
56MP0004957_abnormal_blastocyst_morpholog1.24796551
57MP0002938_white_spotting1.24585221
58MP0005310_abnormal_salivary_gland1.24477976
59MP0000462_abnormal_digestive_system1.24049915
60MP0003705_abnormal_hypodermis_morpholog1.23644009
61MP0004197_abnormal_fetal_growth/weight/1.22384994
62MP0001919_abnormal_reproductive_system1.22338722
63MP0003943_abnormal_hepatobiliary_system1.20691959
64MP0000490_abnormal_crypts_of1.19110351
65MP0000613_abnormal_salivary_gland1.18454906
66MP0002089_abnormal_postnatal_growth/wei1.17551778
67MP0005666_abnormal_adipose_tissue1.15608426
68MP0005670_abnormal_white_adipose1.15010727
69MP0000313_abnormal_cell_death1.12987530
70MP0001697_abnormal_embryo_size1.12454869
71MP0003172_abnormal_lysosome_physiology1.09656999
72MP0001293_anophthalmia1.07350228
73MP0005408_hypopigmentation1.07286299
74MP0010094_abnormal_chromosome_stability1.03834725
75MP0002132_abnormal_respiratory_system1.03737781
76MP0005621_abnormal_cell_physiology1.03326421
77MP0002098_abnormal_vibrissa_morphology1.01807995
78MP0000678_abnormal_parathyroid_gland1.00954845
79MP0002080_prenatal_lethality1.00177841
80MP0000470_abnormal_stomach_morphology0.99267076
81MP0008004_abnormal_stomach_pH0.97067007
82MP0003941_abnormal_skin_development0.97004948
83MP0002086_abnormal_extraembryonic_tissu0.95208723
84MP0009333_abnormal_splenocyte_physiolog0.94668603
85MP0005671_abnormal_response_to0.94618044
86MP0009703_decreased_birth_body0.92551128
87MP0003183_abnormal_peptide_metabolism0.91692902
88MP0003115_abnormal_respiratory_system0.91365150
89MP0004264_abnormal_extraembryonic_tissu0.90802823
90MP0001661_extended_life_span0.90305863
91MP0010307_abnormal_tumor_latency0.89205869
92MP0008057_abnormal_DNA_replication0.89104737
93MP0002210_abnormal_sex_determination0.89086775
94MP0004381_abnormal_hair_follicle0.88918920
95MP0002722_abnormal_immune_system0.86561802
96MP0000733_abnormal_muscle_development0.86236490
97MP0003937_abnormal_limbs/digits/tail_de0.85478150
98MP0001730_embryonic_growth_arrest0.84745320
99MP0002139_abnormal_hepatobiliary_system0.84317169
100MP0000372_irregular_coat_pigmentation0.83752791
101MP0001800_abnormal_humoral_immune0.83147797
102MP0005384_cellular_phenotype0.82895325
103MP0003646_muscle_fatigue0.82823295
104MP0003077_abnormal_cell_cycle0.82805221
105MP0005389_reproductive_system_phenotype0.82013564
106MP0003091_abnormal_cell_migration0.81399720
107MP0004947_skin_inflammation0.80895243
108MP0002160_abnormal_reproductive_system0.80477475
109MP0002925_abnormal_cardiovascular_devel0.79473712
110MP0002085_abnormal_embryonic_tissue0.79055287
111MP0003436_decreased_susceptibility_to0.78956384
112MP0000371_diluted_coat_color0.78932884
113MP0003448_altered_tumor_morphology0.78767422
114MP0000639_abnormal_adrenal_gland0.78625504
115MP0003935_abnormal_craniofacial_develop0.78119467
116MP0000428_abnormal_craniofacial_morphol0.78091602
117MP0001340_abnormal_eyelid_morphology0.77550139
118MP0000703_abnormal_thymus_morphology0.77496127
119MP0005375_adipose_tissue_phenotype0.76889423
120MP0002019_abnormal_tumor_incidence0.76362088
121MP0008007_abnormal_cellular_replicative0.74572869
122MP0002084_abnormal_developmental_patter0.73834238
123MP0001216_abnormal_epidermal_layer0.72307272
124MP0005058_abnormal_lysosome_morphology0.71515261
125MP0000627_abnormal_mammary_gland0.70885141
126MP0000350_abnormal_cell_proliferation0.70663247
127MP0002006_tumorigenesis0.69444081
128MP0005174_abnormal_tail_pigmentation0.68908655
129MP0000685_abnormal_immune_system0.68872511
130MP0009672_abnormal_birth_weight0.68017676
131MP0003936_abnormal_reproductive_system0.67236256
132MP0001666_abnormal_nutrient_absorption0.66888269
133MP0005499_abnormal_olfactory_system0.66505858
134MP0005394_taste/olfaction_phenotype0.66505858
135MP0002398_abnormal_bone_marrow0.66372920
136MP0005395_other_phenotype0.66046546
137MP0008932_abnormal_embryonic_tissue0.66042369
138MP0002796_impaired_skin_barrier0.65359239
139MP0004808_abnormal_hematopoietic_stem0.65354557
140MP0002166_altered_tumor_susceptibility0.63498389
141MP0000427_abnormal_hair_cycle0.63405154
142MP0002075_abnormal_coat/hair_pigmentati0.63137409
143MP0002249_abnormal_larynx_morphology0.61132969
144MP0000003_abnormal_adipose_tissue0.60743001
145MP0001672_abnormal_embryogenesis/_devel0.60732749
146MP0005380_embryogenesis_phenotype0.60732749
147MP0001186_pigmentation_phenotype0.59880812
148MP0000653_abnormal_sex_gland0.58341093
149MP0004272_abnormal_basement_membrane0.56032101
150MP0001663_abnormal_digestive_system0.55996181
151MP0001119_abnormal_female_reproductive0.55548877
152MP0002116_abnormal_craniofacial_bone0.55516114
153MP0001145_abnormal_male_reproductive0.54239914
154MP0004185_abnormal_adipocyte_glucose0.53561555

Predicted human phenotypes

RankGene SetZ-score
1Retinal atrophy (HP:0001105)6.90626732
2Neoplasm of the adrenal cortex (HP:0100641)6.05319615
3Cerebellar dysplasia (HP:0007033)5.78629613
4Hepatoblastoma (HP:0002884)5.40112941
5Anterior segment dysgenesis (HP:0007700)5.18342265
6Spinal rigidity (HP:0003306)4.89669438
7Colon cancer (HP:0003003)4.78512382
8Retinal dysplasia (HP:0007973)4.65691509
9Papillary thyroid carcinoma (HP:0002895)4.61765851
10Occipital encephalocele (HP:0002085)4.60368229
11Subacute progressive viral hepatitis (HP:0006572)4.60263872
12Stomach cancer (HP:0012126)4.58955409
13Buphthalmos (HP:0000557)4.50235178
14Astrocytoma (HP:0009592)4.38457821
15Abnormality of the astrocytes (HP:0100707)4.38457821
16Type II lissencephaly (HP:0007260)4.21462471
17Gonadotropin excess (HP:0000837)4.04290441
18Tented upper lip vermilion (HP:0010804)4.00410500
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.88954109
20Absent speech (HP:0001344)3.81418397
21Glioma (HP:0009733)3.64718042
22Shoulder girdle muscle weakness (HP:0003547)3.53795075
23Slender build (HP:0001533)3.51802524
24Oligodactyly (hands) (HP:0001180)3.50513073
25Medulloblastoma (HP:0002885)3.49234049
26Neoplasm of the oral cavity (HP:0100649)3.48893453
2711 pairs of ribs (HP:0000878)3.45145623
28Epidermoid cyst (HP:0200040)3.30876531
29Renal dysplasia (HP:0000110)3.29985582
30Metaphyseal cupping (HP:0003021)3.29670633
31Osteomalacia (HP:0002749)3.28101166
32Difficulty climbing stairs (HP:0003551)3.26850414
33Truncal obesity (HP:0001956)3.25411130
34Horizontal nystagmus (HP:0000666)3.15748410
35Type 1 muscle fiber predominance (HP:0003803)3.03729679
36Increased nuchal translucency (HP:0010880)3.02504938
37Heterotopia (HP:0002282)2.99771760
38Facial hemangioma (HP:0000329)2.95376709
39Upper motor neuron abnormality (HP:0002127)2.90873772
40Spontaneous abortion (HP:0005268)2.88112991
41Megalocornea (HP:0000485)2.86805597
42Easy fatigability (HP:0003388)2.80970437
43Abnormality of the lower motor neuron (HP:0002366)2.79620511
44Vertebral arch anomaly (HP:0008438)2.76336731
45Abnormality of chromosome segregation (HP:0002916)2.76227028
46Thyroid carcinoma (HP:0002890)2.74777332
47Azoospermia (HP:0000027)2.74096191
48Chest pain (HP:0100749)2.72367888
49Congenital glaucoma (HP:0001087)2.71404217
50Abnormality of the fingertips (HP:0001211)2.71290846
51Menstrual irregularities (HP:0000858)2.69279088
52Nemaline bodies (HP:0003798)2.68510628
53Viral hepatitis (HP:0006562)2.67356402
54Transitional cell carcinoma of the bladder (HP:0006740)2.61305107
55Frequent falls (HP:0002359)2.59419961
56Broad distal phalanx of finger (HP:0009836)2.59386228
57Oligodactyly (HP:0012165)2.57402369
58Capillary hemangiomas (HP:0005306)2.51824429
59Uterine leiomyosarcoma (HP:0002891)2.51672644
60Leiomyosarcoma (HP:0100243)2.51672644
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.50697680
62Limb-girdle muscle weakness (HP:0003325)2.49102099
63Deviation of the thumb (HP:0009603)2.46605254
64Inability to walk (HP:0002540)2.44777647
65Intellectual disability, moderate (HP:0002342)2.42461700
66Proximal placement of thumb (HP:0009623)2.40410981
67Optic nerve hypoplasia (HP:0000609)2.36506200
68Nephroblastoma (Wilms tumor) (HP:0002667)2.35824482
69Flat acetabular roof (HP:0003180)2.33405439
70Chromsome breakage (HP:0040012)2.33211336
71Short nail (HP:0001799)2.32877025
72Increased number of teeth (HP:0011069)2.32664787
73Dislocated radial head (HP:0003083)2.27334901
74Obsessive-compulsive behavior (HP:0000722)2.27196052
75Abnormality of the anterior chamber (HP:0000593)2.25945461
76Amyotrophic lateral sclerosis (HP:0007354)2.24739662
77Dysmetric saccades (HP:0000641)2.24704381
78Deep venous thrombosis (HP:0002625)2.23627253
79Bladder carcinoma (HP:0002862)2.22641060
80Bladder neoplasm (HP:0009725)2.22641060
81Fatigue (HP:0012378)2.21692052
82Progressive external ophthalmoplegia (HP:0000590)2.21249577
83Anal atresia (HP:0002023)2.20134471
84Neonatal hypoglycemia (HP:0001998)2.16789200
85Resting tremor (HP:0002322)2.15047180
86Micronodular cirrhosis (HP:0001413)2.14749012
87Embryonal renal neoplasm (HP:0011794)2.12853272
88Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.12267716
89Limited elbow extension (HP:0001377)2.09506838
90Abnormality of the nasal septum (HP:0000419)2.09505031
91Myopathic facies (HP:0002058)2.08214812
92Rimmed vacuoles (HP:0003805)2.06909472
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05526555
94Abnormality of the radial head (HP:0003995)2.00871955
95Abnormal spermatogenesis (HP:0008669)1.99643874
96Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.99416379
97Ectopic kidney (HP:0000086)1.98451164
98Premature ovarian failure (HP:0008209)1.97985034
99Supernumerary nipples (HP:0002558)1.97403822
100Supernumerary ribs (HP:0005815)1.97145604
101Neoplasm of the small intestine (HP:0100833)1.96607420
102Lip pit (HP:0100267)1.96268529
103Scanning speech (HP:0002168)1.95507700
104Abnormality of DNA repair (HP:0003254)1.95387792
105Volvulus (HP:0002580)1.93683686
106Low anterior hairline (HP:0000294)1.93597158
107Slow saccadic eye movements (HP:0000514)1.92174649
108Degeneration of the lateral corticospinal tracts (HP:0002314)1.91411475
109Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91411475
110Deep palmar crease (HP:0006191)1.90637816
111Neuroectodermal neoplasm (HP:0030061)1.89969379
112Neuroepithelial neoplasm (HP:0030063)1.89969379
113Nervous tissue neoplasm (HP:0030060)1.89969379
114Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.89859462
115Aplasia/Hypoplasia of the sternum (HP:0006714)1.89521237
116Narrow palate (HP:0000189)1.88745053
117Gastrointestinal inflammation (HP:0004386)1.88184013
118Neoplasm of the adrenal gland (HP:0100631)1.85118074
119Microtia (HP:0008551)1.84852914
120Bowel incontinence (HP:0002607)1.83976707
121Cutis marmorata (HP:0000965)1.82350311
122Malignant gastrointestinal tract tumors (HP:0006749)1.81890285
123Gastrointestinal carcinoma (HP:0002672)1.81890285
124Hyperkalemia (HP:0002153)1.81023634
125Open mouth (HP:0000194)1.80733306
126Sandal gap (HP:0001852)1.80690429
127Malignant neoplasm of the central nervous system (HP:0100836)1.79773147
128Macroorchidism (HP:0000053)1.79351628
129Cafe-au-lait spot (HP:0000957)1.79337235
130Long eyelashes (HP:0000527)1.76628232
131Abnormality of the calcaneus (HP:0008364)1.75530616
132Abnormality of the distal phalanx of the thumb (HP:0009617)1.74458441
133Embryonal neoplasm (HP:0002898)1.74348650
134Midline defect of the nose (HP:0004122)1.74085500
135Mildly elevated creatine phosphokinase (HP:0008180)1.72013474
136Abnormality of the thoracic spine (HP:0100711)1.71406210
137Ankle clonus (HP:0011448)1.70968854
138Broad face (HP:0000283)1.70516142
139Missing ribs (HP:0000921)1.70187332
140Hypoplastic iliac wings (HP:0002866)1.69602013
141Abnormal large intestine physiology (HP:0012700)1.67785870
142Type I transferrin isoform profile (HP:0003642)1.67074327
143Severe muscular hypotonia (HP:0006829)1.66600793
144Muscle fiber inclusion bodies (HP:0100299)1.66034629
145Fair hair (HP:0002286)1.64924782
146Basal cell carcinoma (HP:0002671)1.64488148
147Abnormality of the salivary glands (HP:0010286)1.64273392
148Inflammation of the large intestine (HP:0002037)1.64000460
149Intellectual disability, profound (HP:0002187)1.63082244
150Blepharitis (HP:0000498)1.61736198
151Urethral obstruction (HP:0000796)1.61437927
152Abnormality of the phalanges of the hallux (HP:0010057)1.61318698
153Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.59721058
154Germ cell neoplasia (HP:0100728)1.59274234
155Thick eyebrow (HP:0000574)1.59147469
156Broad finger (HP:0001500)1.58088234
157Bicuspid aortic valve (HP:0001647)1.57891063
158Broad palm (HP:0001169)1.57755969
159Supernumerary bones of the axial skeleton (HP:0009144)1.56677525
160Abnormality of the dental root (HP:0006486)1.56057753
161Taurodontia (HP:0000679)1.56057753
162Abnormality of permanent molar morphology (HP:0011071)1.56057753
163Rhabdomyosarcoma (HP:0002859)1.55933598
164Abnormal protein glycosylation (HP:0012346)1.55845389
165Abnormal glycosylation (HP:0012345)1.55845389
166Abnormal protein N-linked glycosylation (HP:0012347)1.55845389
167Tubulointerstitial nephritis (HP:0001970)1.55833761
168Meningocele (HP:0002435)1.55155653
169Gynecomastia (HP:0000771)1.54278123
170Hypogonadotrophic hypogonadism (HP:0000044)1.53478689
171Atresia of the external auditory canal (HP:0000413)1.51287958
172Intestinal fistula (HP:0100819)1.50948114
173Erectile abnormalities (HP:0100639)1.49512772
174Hamartoma (HP:0010566)1.46989385
175Difficulty walking (HP:0002355)1.44983300
176Aplasia/Hypoplasia of the brainstem (HP:0007362)1.44550040
177Hypoplasia of the brainstem (HP:0002365)1.44550040
178Absent frontal sinuses (HP:0002688)1.44137608
179Uterine neoplasm (HP:0010784)1.42177739
180Severe visual impairment (HP:0001141)1.41879029
181Deep philtrum (HP:0002002)1.41857697
182Ragged-red muscle fibers (HP:0003200)1.40230702
183Lumbar hyperlordosis (HP:0002938)1.39650784
184EMG: neuropathic changes (HP:0003445)1.39648639
185Shawl scrotum (HP:0000049)1.39369852

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD45.96606144
2CDK124.25926893
3CAMK1G3.98189276
4MET3.72244002
5CSNK1A1L3.46942960
6LATS12.79721016
7PNCK2.64904896
8CSNK1G32.60593771
9CDK92.56209737
10FGR2.54117160
11CAMK1D2.53970166
12FES2.40549937
13CSNK1G12.34572279
14CDK192.30739630
15TRIB32.27364436
16BMX2.26847845
17SMG12.14176754
18CSNK1G22.10584822
19CSF1R2.00762701
20EEF2K1.99446116
21PTK2B1.91354124
22FRK1.88965374
23RIPK11.80079652
24SGK21.76951243
25RET1.63855332
26TXK1.52160504
27SGK31.47740704
28MKNK21.43666542
29FGFR41.42077107
30FGFR31.36585496
31ERN11.35213053
32MARK21.30677152
33CHEK21.27815161
34FER1.24302722
35KSR21.23951791
36MARK31.23660042
37CDK61.19564136
38ZAK1.16004335
39WNK11.14955178
40MAP4K11.13317611
41MAP3K91.12769189
42NEK91.11133012
43MAP3K21.06542446
44MAP3K71.05935503
45KSR11.02232698
46PASK0.99186896
47PIM10.98984719
48ATR0.98531398
49ICK0.97310026
50PRPF4B0.96158297
51SIK30.94158156
52YES10.92948393
53STK40.88897133
54MAP3K130.88590801
55TRPM70.87897806
56RPS6KB10.87549371
57SGK4940.86054938
58SGK2230.86054938
59RIPK40.86026764
60STK30.85982522
61CSNK1D0.84246528
62NLK0.84089267
63JAK10.82983029
64STK380.80873644
65TYK20.80458331
66PTK20.80148272
67BRAF0.79274623
68CHUK0.77701699
69MST1R0.76861519
70ERBB40.75518701
71NEK60.74626616
72MELK0.73852576
73JAK30.72626621
74MAPK110.72139122
75STK100.71822646
76STK38L0.71589059
77FGFR20.70927034
78MTOR0.69867739
79FLT30.69628668
80PDPK10.68564602
81CDC70.67938850
82MAP2K30.67917803
83PDK10.65892870
84CDK70.65224754
85CAMK40.64863302
86FGFR10.63975205
87SIK20.62343165
88TTK0.60469975
89ITK0.59798793
90RPS6KB20.59454214
91CAMK10.57547692
92CSK0.57266577
93IRAK20.56964278
94ALK0.55596843
95MAP3K140.53612076
96OXSR10.53505924
97TAOK30.53118190
98ZAP700.53068123
99TAOK10.52656548
100MAP2K20.52492983
101PTK60.52179030
102TYRO30.51937447
103IRAK40.51569080
104ATM0.50400669
105TAOK20.50350945
106CDK30.49865547
107SGK10.49842285
108AKT30.48666785
109TNK20.48588392
110HCK0.48313788
111PDGFRA0.47964926
112PRKAA10.47712393
113CDC42BPA0.47562613
114NUAK10.46549003
115MKNK10.46350380
116GSK3B0.46259584
117HIPK20.44526600
118AKT10.43784368
119PRKAA20.43497993
120PRKD30.43226621
121STK110.42487376
122MAP3K10.41763939
123PKN20.41570183
124* CHEK10.41506313
125WNK30.41334279
126MAPK10.39889330
127EGFR0.39818286
128INSRR0.39609395
129SIK10.39574419
130MAPK100.39445345
131AKT20.39373292
132CDK40.39012882
133MAP3K80.38971726
134NEK20.38613971
135PDGFRB0.38502793
136MAP3K100.38208495
137IRAK30.38006184
138PRKCH0.37170776
139MAPK140.36926864
140MAP3K30.36701771
141PRKCI0.36043741
142TSSK60.35839613
143IRAK10.35248940
144MAPK80.34723949
145IKBKB0.34345418
146* CDK10.34225754
147CDK20.33651906
148STK240.33154610
149MAPK30.30998543
150RAF10.30579452
151PLK10.30199246
152EPHA20.27777853

Predicted pathways (KEGG)

RankGene SetZ-score
1Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.54521689
2Sulfur metabolism_Homo sapiens_hsa009202.53657198
3Endometrial cancer_Homo sapiens_hsa052132.12660501
4Selenocompound metabolism_Homo sapiens_hsa004501.83679949
5Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.82480426
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76912793
7RNA transport_Homo sapiens_hsa030131.76244633
8VEGF signaling pathway_Homo sapiens_hsa043701.60301069
9Colorectal cancer_Homo sapiens_hsa052101.53384067
10Thyroid cancer_Homo sapiens_hsa052161.44418941
11Transcriptional misregulation in cancer_Homo sapiens_hsa052021.40201616
12Autoimmune thyroid disease_Homo sapiens_hsa053201.40131828
13MicroRNAs in cancer_Homo sapiens_hsa052061.35804682
14Caffeine metabolism_Homo sapiens_hsa002321.32326130
15Oocyte meiosis_Homo sapiens_hsa041141.29447758
16Renal cell carcinoma_Homo sapiens_hsa052111.27485324
17DNA replication_Homo sapiens_hsa030301.27291112
18Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.24423828
19Thyroid hormone signaling pathway_Homo sapiens_hsa049191.22110065
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21859834
21Primary immunodeficiency_Homo sapiens_hsa053401.21447890
22Chronic myeloid leukemia_Homo sapiens_hsa052201.19363003
23Basal cell carcinoma_Homo sapiens_hsa052171.18777555
24Dorso-ventral axis formation_Homo sapiens_hsa043201.14654556
25Herpes simplex infection_Homo sapiens_hsa051681.14360290
26Lysine degradation_Homo sapiens_hsa003101.13143969
27Acute myeloid leukemia_Homo sapiens_hsa052211.11539710
28Measles_Homo sapiens_hsa051621.11441195
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.09871685
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.09501987
31B cell receptor signaling pathway_Homo sapiens_hsa046621.08362795
32Pancreatic cancer_Homo sapiens_hsa052121.07540150
33Adherens junction_Homo sapiens_hsa045201.07365535
34Systemic lupus erythematosus_Homo sapiens_hsa053221.04259926
35Wnt signaling pathway_Homo sapiens_hsa043101.04252667
36Insulin resistance_Homo sapiens_hsa049311.02554664
37Insulin signaling pathway_Homo sapiens_hsa049101.00872619
38Prostate cancer_Homo sapiens_hsa052151.00360413
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00307837
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00202878
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00133085
42Influenza A_Homo sapiens_hsa051640.98873019
43Long-term depression_Homo sapiens_hsa047300.97586568
44Nucleotide excision repair_Homo sapiens_hsa034200.95809643
45TGF-beta signaling pathway_Homo sapiens_hsa043500.95254388
46Jak-STAT signaling pathway_Homo sapiens_hsa046300.95124859
47Hepatitis B_Homo sapiens_hsa051610.94152326
48T cell receptor signaling pathway_Homo sapiens_hsa046600.93081637
49Neurotrophin signaling pathway_Homo sapiens_hsa047220.92890623
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91689803
51mTOR signaling pathway_Homo sapiens_hsa041500.91039682
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.90087452
53Mismatch repair_Homo sapiens_hsa034300.89901825
54Homologous recombination_Homo sapiens_hsa034400.88972891
55Hippo signaling pathway_Homo sapiens_hsa043900.88542106
56FoxO signaling pathway_Homo sapiens_hsa040680.86921729
57HTLV-I infection_Homo sapiens_hsa051660.86303887
58Cell cycle_Homo sapiens_hsa041100.86282384
59Prion diseases_Homo sapiens_hsa050200.85778361
60Non-homologous end-joining_Homo sapiens_hsa034500.85566478
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85300597
62Renin secretion_Homo sapiens_hsa049240.85135179
63Circadian entrainment_Homo sapiens_hsa047130.84912090
64Inositol phosphate metabolism_Homo sapiens_hsa005620.84315912
65Alcoholism_Homo sapiens_hsa050340.83946706
66Non-small cell lung cancer_Homo sapiens_hsa052230.83421658
67Fanconi anemia pathway_Homo sapiens_hsa034600.83248967
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82074006
69AMPK signaling pathway_Homo sapiens_hsa041520.81962448
70Small cell lung cancer_Homo sapiens_hsa052220.81907757
71cAMP signaling pathway_Homo sapiens_hsa040240.81751748
72Prolactin signaling pathway_Homo sapiens_hsa049170.81647400
73Spliceosome_Homo sapiens_hsa030400.81001002
74Regulation of autophagy_Homo sapiens_hsa041400.80414631
75Chemokine signaling pathway_Homo sapiens_hsa040620.80219425
76N-Glycan biosynthesis_Homo sapiens_hsa005100.79905245
77Glioma_Homo sapiens_hsa052140.79784021
78Viral carcinogenesis_Homo sapiens_hsa052030.79708109
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78645382
80mRNA surveillance pathway_Homo sapiens_hsa030150.77433173
81Osteoclast differentiation_Homo sapiens_hsa043800.76853414
82Type II diabetes mellitus_Homo sapiens_hsa049300.76748929
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76618597
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76601171
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76482147
86Hematopoietic cell lineage_Homo sapiens_hsa046400.76321584
87Notch signaling pathway_Homo sapiens_hsa043300.75894414
88Base excision repair_Homo sapiens_hsa034100.75493858
89TNF signaling pathway_Homo sapiens_hsa046680.75072575
90Platelet activation_Homo sapiens_hsa046110.74648834
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.74112336
92Epstein-Barr virus infection_Homo sapiens_hsa051690.73942742
93Toxoplasmosis_Homo sapiens_hsa051450.73480054
94Fatty acid biosynthesis_Homo sapiens_hsa000610.71525692
95Hepatitis C_Homo sapiens_hsa051600.70997114
96ErbB signaling pathway_Homo sapiens_hsa040120.70882524
97Viral myocarditis_Homo sapiens_hsa054160.70205745
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69657383
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69245286
100Basal transcription factors_Homo sapiens_hsa030220.68033809
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67946887
102Pathways in cancer_Homo sapiens_hsa052000.67740473
103MAPK signaling pathway_Homo sapiens_hsa040100.67500942
104HIF-1 signaling pathway_Homo sapiens_hsa040660.66548580
105Circadian rhythm_Homo sapiens_hsa047100.66508676
106Phototransduction_Homo sapiens_hsa047440.65294872
107Amoebiasis_Homo sapiens_hsa051460.65111648
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65045085
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64461256
110RNA degradation_Homo sapiens_hsa030180.63732864
111Other glycan degradation_Homo sapiens_hsa005110.62397577
112Insulin secretion_Homo sapiens_hsa049110.62152802
113ABC transporters_Homo sapiens_hsa020100.62052190
114p53 signaling pathway_Homo sapiens_hsa041150.61540396
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.61486095
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61385042
117Legionellosis_Homo sapiens_hsa051340.60938641
118Leishmaniasis_Homo sapiens_hsa051400.60582669
119Melanoma_Homo sapiens_hsa052180.60458216
120Estrogen signaling pathway_Homo sapiens_hsa049150.60207627
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.60173885
122Apoptosis_Homo sapiens_hsa042100.59132368
123Choline metabolism in cancer_Homo sapiens_hsa052310.56509607
124Complement and coagulation cascades_Homo sapiens_hsa046100.55760605
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54857567
126Proteoglycans in cancer_Homo sapiens_hsa052050.53694355
127Cocaine addiction_Homo sapiens_hsa050300.53543987
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53165550
129Tuberculosis_Homo sapiens_hsa051520.52490575
130Glucagon signaling pathway_Homo sapiens_hsa049220.52475029
131Focal adhesion_Homo sapiens_hsa045100.51537770
132Shigellosis_Homo sapiens_hsa051310.50928033
133Glutamatergic synapse_Homo sapiens_hsa047240.50860226
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.50628699
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49457364
136Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48364620

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »