PHGDH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.10424510
2DNA unwinding involved in DNA replication (GO:0006268)4.97335907
3DNA strand elongation (GO:0022616)4.85291284
4nucleobase biosynthetic process (GO:0046112)4.76114270
5DNA deamination (GO:0045006)4.71832882
6telomere maintenance via semi-conservative replication (GO:0032201)4.68114286
7formation of translation preinitiation complex (GO:0001731)4.64509682
8DNA replication initiation (GO:0006270)4.64485456
9ribosomal small subunit assembly (GO:0000028)4.58185143
10maturation of SSU-rRNA (GO:0030490)4.49105224
11purine nucleobase biosynthetic process (GO:0009113)4.35688624
12ribosome assembly (GO:0042255)4.28425167
13viral transcription (GO:0019083)4.25220999
14IMP biosynthetic process (GO:0006188)4.20209493
15translational termination (GO:0006415)4.17361206
16* serine family amino acid biosynthetic process (GO:0009070)4.11963881
17heterochromatin organization (GO:0070828)4.05820054
18telomere maintenance via recombination (GO:0000722)4.03234768
19ribosomal small subunit biogenesis (GO:0042274)3.95194940
20protein localization to kinetochore (GO:0034501)3.94675795
21IMP metabolic process (GO:0046040)3.87483688
22translational elongation (GO:0006414)3.87235293
23translational initiation (GO:0006413)3.86050114
24folic acid-containing compound biosynthetic process (GO:0009396)3.81191901
25ribosomal large subunit biogenesis (GO:0042273)3.79140044
26ribosome biogenesis (GO:0042254)3.78463196
27mitotic recombination (GO:0006312)3.77461049
28ribonucleoprotein complex biogenesis (GO:0022613)3.76654961
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.75737773
30protein complex localization (GO:0031503)3.75114669
31mitotic chromosome condensation (GO:0007076)3.75068398
32telomere maintenance via telomere lengthening (GO:0010833)3.70562638
33cotranslational protein targeting to membrane (GO:0006613)3.69222562
34protein targeting to ER (GO:0045047)3.67205986
35nuclear pore complex assembly (GO:0051292)3.63431635
36DNA replication checkpoint (GO:0000076)3.63266872
37establishment of viral latency (GO:0019043)3.59123539
38mitotic nuclear envelope disassembly (GO:0007077)3.57337508
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.57144034
40nucleotide-excision repair, DNA gap filling (GO:0006297)3.57006502
41rRNA processing (GO:0006364)3.53920639
42DNA replication-dependent nucleosome assembly (GO:0006335)3.50567782
43DNA replication-dependent nucleosome organization (GO:0034723)3.50567782
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.50525219
45nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.50522535
46protein localization to endoplasmic reticulum (GO:0070972)3.49280940
47rRNA metabolic process (GO:0016072)3.40011264
48sister chromatid segregation (GO:0000819)3.38489588
49pseudouridine synthesis (GO:0001522)3.37623088
50* L-serine metabolic process (GO:0006563)3.34388726
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.34207056
52spliceosomal snRNP assembly (GO:0000387)3.33738190
53proline biosynthetic process (GO:0006561)3.31215547
54anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.31151725
55mitotic metaphase plate congression (GO:0007080)3.30351731
56cellular protein complex disassembly (GO:0043624)3.27917787
57nuclear pore organization (GO:0006999)3.27110524
58regulation of spindle organization (GO:0090224)3.26968259
59protein localization to chromosome, centromeric region (GO:0071459)3.26394456
60nuclear envelope disassembly (GO:0051081)3.25586215
61membrane disassembly (GO:0030397)3.25586215
62regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.24404635
63viral life cycle (GO:0019058)3.23488811
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.21609127
65proteasome assembly (GO:0043248)3.20574900
66CENP-A containing nucleosome assembly (GO:0034080)3.19365190
67positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18646000
68negative regulation of ligase activity (GO:0051352)3.16940626
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16940626
70folic acid metabolic process (GO:0046655)3.16679434
71negative regulation of mRNA processing (GO:0050686)3.11639052
72regulation of posttranscriptional gene silencing (GO:0060147)3.09802231
73regulation of gene silencing by miRNA (GO:0060964)3.09802231
74regulation of gene silencing by RNA (GO:0060966)3.09802231
75translation (GO:0006412)3.08392914
76histone arginine methylation (GO:0034969)3.08228764
77chromatin remodeling at centromere (GO:0031055)3.05738377
78G1/S transition of mitotic cell cycle (GO:0000082)3.04970739
79cell cycle G1/S phase transition (GO:0044843)3.04970739
80tetrahydrofolate metabolic process (GO:0046653)3.02290063
81pre-miRNA processing (GO:0031054)3.00397452
82protein complex disassembly (GO:0043241)3.00386819
83L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.99393122
84peptidyl-arginine omega-N-methylation (GO:0035247)2.98390117
85deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.97831697
86transcription-coupled nucleotide-excision repair (GO:0006283)2.97009910
87DNA replication-independent nucleosome organization (GO:0034724)2.96805970
88DNA replication-independent nucleosome assembly (GO:0006336)2.96805970
89DNA ligation (GO:0006266)2.94193334
90tRNA aminoacylation for protein translation (GO:0006418)2.93344764
91paraxial mesoderm development (GO:0048339)2.92126417
92translesion synthesis (GO:0019985)2.88932192
93negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.86209655
94convergent extension (GO:0060026)2.85991294
95planar cell polarity pathway involved in neural tube closure (GO:0090179)2.85918394
96nuclear-transcribed mRNA catabolic process (GO:0000956)2.85391630
97chromatin assembly or disassembly (GO:0006333)2.84684810
98DNA duplex unwinding (GO:0032508)2.84433025
99DNA strand renaturation (GO:0000733)2.84225076
100cellular protein complex localization (GO:0034629)2.84136007
101mitochondrial DNA metabolic process (GO:0032042)2.84067829
102establishment of integrated proviral latency (GO:0075713)2.83032289
103tRNA aminoacylation (GO:0043039)2.82770971
104amino acid activation (GO:0043038)2.82770971
105pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.82534354
106nucleosome disassembly (GO:0006337)2.82263993
107protein-DNA complex disassembly (GO:0032986)2.82263993
108histone-serine phosphorylation (GO:0035404)2.81701182
109DNA geometric change (GO:0032392)2.80952619
110negative regulation of RNA splicing (GO:0033119)2.80151574
111chromatin assembly (GO:0031497)2.80065801
112macromolecular complex disassembly (GO:0032984)2.79255711
113ATP-dependent chromatin remodeling (GO:0043044)2.78935229
114mitotic sister chromatid segregation (GO:0000070)2.77302846
115cellular component biogenesis (GO:0044085)2.76666606
116positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.76653777
117nuclear envelope organization (GO:0006998)2.76617534
118negative regulation of mRNA metabolic process (GO:1903312)2.76517061
119metaphase plate congression (GO:0051310)2.76397118
120histone exchange (GO:0043486)2.75977356
121RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.75874901
122mRNA splicing, via spliceosome (GO:0000398)2.75874901
123DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.74547630
124RNA splicing, via transesterification reactions (GO:0000375)2.74010116
125telomere organization (GO:0032200)2.73925173
126negative regulation of chromosome segregation (GO:0051985)2.73763867
127positive regulation of chromosome segregation (GO:0051984)2.72601656
128pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.72348100
129regulation of translational fidelity (GO:0006450)2.72220776
130base-excision repair (GO:0006284)2.71731731
131non-recombinational repair (GO:0000726)2.71721046
132double-strand break repair via nonhomologous end joining (GO:0006303)2.71721046
133kinetochore organization (GO:0051383)2.71502504
134intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.71489442
135signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.71489442
136signal transduction involved in DNA integrity checkpoint (GO:0072401)2.71470744
137signal transduction involved in DNA damage checkpoint (GO:0072422)2.71470744
138telomere maintenance (GO:0000723)2.71368623
139DNA topological change (GO:0006265)2.68235682
140pore complex assembly (GO:0046931)2.66524735
141pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.65208197
142mitotic sister chromatid cohesion (GO:0007064)2.64055647
143regulation of translational elongation (GO:0006448)2.64028306
144negative regulation of mitotic sister chromatid separation (GO:2000816)2.62495527
145negative regulation of sister chromatid segregation (GO:0033046)2.62495527
146negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.62495527
147negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.62495527
148negative regulation of mitotic sister chromatid segregation (GO:0033048)2.62495527
149* glycine metabolic process (GO:0006544)2.62122099

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.65838315
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.28887601
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.06040501
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.34927023
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.06863120
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97128421
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95600361
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.92017826
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.90411618
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89229614
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80850608
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.80067769
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78244919
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.68847407
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66883658
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66371145
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.58722085
18XRN2_22483619_ChIP-Seq_HELA_Human2.42976605
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.28973268
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24884113
21AR_21909140_ChIP-Seq_LNCAP_Human2.19851844
22VDR_23849224_ChIP-Seq_CD4+_Human2.18747842
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08840567
24E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98713013
25DCP1A_22483619_ChIP-Seq_HELA_Human1.96065250
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94780591
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94230756
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.92776332
29FOXP3_21729870_ChIP-Seq_TREG_Human1.90782902
30GABP_19822575_ChIP-Seq_HepG2_Human1.89069826
31MYC_22102868_ChIP-Seq_BL_Human1.87393256
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82495838
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79390569
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.78348575
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75468454
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74529280
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74458449
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.73342587
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.72610234
40CIITA_25753668_ChIP-Seq_RAJI_Human1.71694402
41TTF2_22483619_ChIP-Seq_HELA_Human1.69732142
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65108431
43* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64859574
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56079617
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53348828
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52594029
47VDR_21846776_ChIP-Seq_THP-1_Human1.51833745
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50370851
49KDM5A_27292631_Chip-Seq_BREAST_Human1.49230836
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47932145
51ZNF263_19887448_ChIP-Seq_K562_Human1.47269211
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46430798
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42832556
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40776924
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39479174
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.37942981
57* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37581808
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.36956257
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33800764
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32040682
61ELK1_19687146_ChIP-ChIP_HELA_Human1.30980176
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30752590
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.29397862
64TCF3_18692474_ChIP-Seq_MEFs_Mouse1.28246374
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27426732
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.26245428
67NANOG_21062744_ChIP-ChIP_HESCs_Human1.23863964
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23653359
69TFEB_21752829_ChIP-Seq_HELA_Human1.23362466
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23347398
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23176282
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22251431
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21381552
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20447100
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20223900
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20059586
77KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16134447
78KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16134447
79KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16134447
80* NANOG_16153702_ChIP-ChIP_HESCs_Human1.15993293
81* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13411092
82KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10509675
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09677594
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08342841
85SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07777993
86NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04968571
87* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04404585
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04299752
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04148651
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03717467
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03211231
92ELK1_22589737_ChIP-Seq_MCF10A_Human1.03179825
93OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03025303
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01344560
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01339045
96* SPI1_23547873_ChIP-Seq_NB4_Human0.99346123
97TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99046740
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97128604
99SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96533114
100* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96233982
101ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95559896
102PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94512812
103CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94220281
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93170058
105NOTCH1_21737748_ChIP-Seq_TLL_Human0.93112213
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.92664660
107NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92020396
108TP63_19390658_ChIP-ChIP_HaCaT_Human0.91149677
109* CHD1_26751641_Chip-Seq_LNCaP_Human0.91072588
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89352041
111PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89349974
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89165046
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88642738
114TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87563631
115FOXP1_21924763_ChIP-Seq_HESCs_Human0.87328081
116CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86801216
117POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84365716
118SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.84189628
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84154362
120CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82600498
121TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82405791
122SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81337854
123RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.80235071
124GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79565784
125MYB_21317192_ChIP-Seq_ERMYB_Mouse0.79484724
126FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78139100
127ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78003156
128MYC_18940864_ChIP-ChIP_HL60_Human0.77121398
129MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.76707133
130TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76430743
131ELK3_25401928_ChIP-Seq_HUVEC_Human0.75401083

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.06767970
2MP0003111_abnormal_nucleus_morphology4.13900437
3MP0004957_abnormal_blastocyst_morpholog4.03744719
4MP0010094_abnormal_chromosome_stability3.98892986
5MP0003077_abnormal_cell_cycle3.66169314
6MP0002396_abnormal_hematopoietic_system3.13544823
7MP0008057_abnormal_DNA_replication3.03273315
8MP0008007_abnormal_cellular_replicative3.01433987
9MP0008932_abnormal_embryonic_tissue2.54242956
10MP0008058_abnormal_DNA_repair2.53625281
11MP0003941_abnormal_skin_development2.34302054
12MP0001730_embryonic_growth_arrest2.25169301
13MP0000566_synostosis2.16810724
14MP0010352_gastrointestinal_tract_polyps2.13136301
15MP0000350_abnormal_cell_proliferation2.07814058
16MP0006292_abnormal_olfactory_placode2.05151115
17MP0003136_yellow_coat_color2.02692132
18MP0000490_abnormal_crypts_of1.97799359
19MP0002697_abnormal_eye_size1.87760823
20MP0009333_abnormal_splenocyte_physiolog1.84233070
21MP0003786_premature_aging1.67784694
22MP0010307_abnormal_tumor_latency1.63259409
23MP0004808_abnormal_hematopoietic_stem1.62453785
24MP0002254_reproductive_system_inflammat1.56082122
25MP0004233_abnormal_muscle_weight1.55867041
26MP0003123_paternal_imprinting1.52378024
27* MP0002080_prenatal_lethality1.51951369
28MP0009379_abnormal_foot_pigmentation1.51546900
29MP0008438_abnormal_cutaneous_collagen1.48055900
30MP0000049_abnormal_middle_ear1.47819093
31MP0003763_abnormal_thymus_physiology1.47055839
32MP0009840_abnormal_foam_cell1.46234123
33MP0002019_abnormal_tumor_incidence1.45460593
34MP0000537_abnormal_urethra_morphology1.44262912
35MP0001853_heart_inflammation1.44230318
36MP0004858_abnormal_nervous_system1.43792230
37MP0003890_abnormal_embryonic-extraembry1.39325319
38MP0003942_abnormal_urinary_system1.38278115
39MP0006054_spinal_hemorrhage1.38041444
40MP0001672_abnormal_embryogenesis/_devel1.37905419
41MP0005380_embryogenesis_phenotype1.37905419
42MP0010030_abnormal_orbit_morphology1.36616052
43* MP0001697_abnormal_embryo_size1.35640316
44MP0000313_abnormal_cell_death1.35070494
45MP0001286_abnormal_eye_development1.34214603
46MP0002249_abnormal_larynx_morphology1.33641023
47MP0000579_abnormal_nail_morphology1.33158366
48MP0001346_abnormal_lacrimal_gland1.31907321
49MP0003315_abnormal_perineum_morphology1.31720552
50MP0003718_maternal_effect1.29852232
51MP0003119_abnormal_digestive_system1.28739963
52MP0001849_ear_inflammation1.27581322
53MP0009053_abnormal_anal_canal1.26269031
54MP0000465_gastrointestinal_hemorrhage1.22867425
55MP0003984_embryonic_growth_retardation1.22824588
56MP0005397_hematopoietic_system_phenotyp1.22005130
57MP0001545_abnormal_hematopoietic_system1.22005130
58* MP0002085_abnormal_embryonic_tissue1.20913881
59MP0000703_abnormal_thymus_morphology1.19973366
60MP0002233_abnormal_nose_morphology1.18605794
61MP0000858_altered_metastatic_potential1.17792627
62MP0002088_abnormal_embryonic_growth/wei1.17454869
63MP0005623_abnormal_meninges_morphology1.16758018
64MP0000685_abnormal_immune_system1.16236898
65MP0003186_abnormal_redox_activity1.15937688
66MP0002398_abnormal_bone_marrow1.15370381
67MP0002722_abnormal_immune_system1.14329685
68* MP0003861_abnormal_nervous_system1.12699223
69MP0004197_abnormal_fetal_growth/weight/1.11642975
70MP0000689_abnormal_spleen_morphology1.10724286
71MP0002084_abnormal_developmental_patter1.08362636
72MP0001293_anophthalmia1.06000185
73MP0003122_maternal_imprinting1.05228379
74MP0003385_abnormal_body_wall1.03776815
75MP0003755_abnormal_palate_morphology1.03684838
76MP0001299_abnormal_eye_distance/1.03563910
77MP0005023_abnormal_wound_healing1.03372403
78MP0000358_abnormal_cell_content/1.03107732
79MP0009703_decreased_birth_body1.02876076
80MP0003115_abnormal_respiratory_system1.01524409
81MP0009278_abnormal_bone_marrow1.01429919
82MP0003567_abnormal_fetal_cardiomyocyte0.99552698
83MP0004133_heterotaxia0.98835944
84MP0005075_abnormal_melanosome_morpholog0.98074451
85MP0000762_abnormal_tongue_morphology0.96668847
86MP0001188_hyperpigmentation0.96028983
87MP0005501_abnormal_skin_physiology0.95905243
88MP0002429_abnormal_blood_cell0.95805484
89MP0002086_abnormal_extraembryonic_tissu0.94916568
90MP0006035_abnormal_mitochondrial_morpho0.94176360
91MP0004272_abnormal_basement_membrane0.93546869
92MP0000428_abnormal_craniofacial_morphol0.93449403
93MP0000733_abnormal_muscle_development0.92475095
94MP0003121_genomic_imprinting0.92403730
95MP0000432_abnormal_head_morphology0.91654882
96MP0005220_abnormal_exocrine_pancreas0.90812979
97MP0005499_abnormal_olfactory_system0.90458624
98MP0005394_taste/olfaction_phenotype0.90458624
99MP0002111_abnormal_tail_morphology0.90316202
100MP0009697_abnormal_copulation0.90315882
101MP0000383_abnormal_hair_follicle0.88067378
102MP0000716_abnormal_immune_system0.87716393
103MP0009250_abnormal_appendicular_skeleto0.87085833
104MP0003806_abnormal_nucleotide_metabolis0.85821458
105MP0008789_abnormal_olfactory_epithelium0.85271261
106MP0002116_abnormal_craniofacial_bone0.84967294
107MP0005621_abnormal_cell_physiology0.84926181
108MP0001873_stomach_inflammation0.84598198
109MP0000750_abnormal_muscle_regeneration0.84357773
110MP0008260_abnormal_autophagy0.83637187
111MP0005384_cellular_phenotype0.82357528
112MP0003938_abnormal_ear_development0.81983274
113MP0002092_abnormal_eye_morphology0.81836311
114MP0003935_abnormal_craniofacial_develop0.81063579
115MP0004185_abnormal_adipocyte_glucose0.80659728
116MP0002210_abnormal_sex_determination0.80598430
117MP0001145_abnormal_male_reproductive0.80302591
118MP0002234_abnormal_pharynx_morphology0.79608346
119MP0001529_abnormal_vocalization0.79473512
120MP0000678_abnormal_parathyroid_gland0.79086239
121MP0002938_white_spotting0.78564176
122MP0003705_abnormal_hypodermis_morpholog0.77840961
123MP0002132_abnormal_respiratory_system0.77422119
124MP0002114_abnormal_axial_skeleton0.76482630
125MP0005076_abnormal_cell_differentiation0.75878829
126MP0005257_abnormal_intraocular_pressure0.75869968
127MP0008877_abnormal_DNA_methylation0.75487110
128MP0002081_perinatal_lethality0.74740359
129MP0003878_abnormal_ear_physiology0.74565301
130MP0005377_hearing/vestibular/ear_phenot0.74565301
131MP0009672_abnormal_birth_weight0.73583420
132MP0003221_abnormal_cardiomyocyte_apopto0.72911807
133MP0002420_abnormal_adaptive_immunity0.71430082
134MP0000377_abnormal_hair_follicle0.70279637
135MP0002095_abnormal_skin_pigmentation0.70076324
136MP0003937_abnormal_limbs/digits/tail_de0.69897614
137MP0001348_abnormal_lacrimal_gland0.69729540
138MP0000477_abnormal_intestine_morphology0.69467493
139MP0001819_abnormal_immune_cell0.68374837
140MP0002166_altered_tumor_susceptibility0.68220107
141MP0003566_abnormal_cell_adhesion0.67896680
142MP0002075_abnormal_coat/hair_pigmentati0.65592992
143MP0010678_abnormal_skin_adnexa0.63801708
144MP0002089_abnormal_postnatal_growth/wei0.63736686
145MP0002405_respiratory_system_inflammati0.63614241
146MP0005058_abnormal_lysosome_morphology0.63415805
147MP0001243_abnormal_dermal_layer0.63244551
148MP0002160_abnormal_reproductive_system0.63004744
149MP0002452_abnormal_antigen_presenting0.62756141
150MP0002006_tumorigenesis0.62022927
151MP0001915_intracranial_hemorrhage0.61623252
152MP0001661_extended_life_span0.59357057
153MP0003279_aneurysm0.58776662

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)4.35937867
2Reticulocytopenia (HP:0001896)4.12410148
3Selective tooth agenesis (HP:0001592)4.09120983
4Abnormality of cells of the erythroid lineage (HP:0012130)4.07680998
5Birth length less than 3rd percentile (HP:0003561)3.99558874
6Abnormal number of erythroid precursors (HP:0012131)3.88625380
7Cortical dysplasia (HP:0002539)3.40449624
8Breast hypoplasia (HP:0003187)3.30421520
9Thrombocytosis (HP:0001894)3.29374424
10Rough bone trabeculation (HP:0100670)3.28657692
11Abnormality of the labia minora (HP:0012880)3.08969250
12Colon cancer (HP:0003003)3.04052061
13Aplastic anemia (HP:0001915)3.02799785
14Microretrognathia (HP:0000308)2.86985309
15Degeneration of anterior horn cells (HP:0002398)2.84305335
16Abnormality of the anterior horn cell (HP:0006802)2.84305335
17Entropion (HP:0000621)2.80073766
18Oral leukoplakia (HP:0002745)2.79730785
19Spastic diplegia (HP:0001264)2.79694337
20Trismus (HP:0000211)2.75563346
21* Macrocytic anemia (HP:0001972)2.72840995
22CNS hypomyelination (HP:0003429)2.72287024
23Multiple enchondromatosis (HP:0005701)2.70678390
2411 pairs of ribs (HP:0000878)2.68672747
25Carpal bone hypoplasia (HP:0001498)2.67666665
26Duplication of thumb phalanx (HP:0009942)2.63674725
27Premature rupture of membranes (HP:0001788)2.61048453
28Microvesicular hepatic steatosis (HP:0001414)2.56904726
29Pallor (HP:0000980)2.55929957
30Glossoptosis (HP:0000162)2.50806856
31Postnatal microcephaly (HP:0005484)2.50578360
32Premature graying of hair (HP:0002216)2.48311468
33Progressive muscle weakness (HP:0003323)2.46167878
34Partial duplication of thumb phalanx (HP:0009944)2.45945623
35High anterior hairline (HP:0009890)2.40290996
36Neoplasm of the pancreas (HP:0002894)2.40174332
37Abnormality of cochlea (HP:0000375)2.37034580
38Nephroblastoma (Wilms tumor) (HP:0002667)2.31818376
39Patellar aplasia (HP:0006443)2.28302088
40Ankle contracture (HP:0006466)2.26252959
41Pancytopenia (HP:0001876)2.25218404
42Abnormal trabecular bone morphology (HP:0100671)2.24635861
43Septo-optic dysplasia (HP:0100842)2.24089885
44IgM deficiency (HP:0002850)2.21202166
45Chronic otitis media (HP:0000389)2.20212219
46Choanal stenosis (HP:0000452)2.19479566
47Broad distal phalanx of finger (HP:0009836)2.18883214
48Aplasia/Hypoplasia of the patella (HP:0006498)2.18550998
49Squamous cell carcinoma (HP:0002860)2.17350352
50Partial duplication of the phalanx of hand (HP:0009999)2.16162602
51Coronal craniosynostosis (HP:0004440)2.16080997
52Protrusio acetabuli (HP:0003179)2.15562875
53Hypoplasia of the capital femoral epiphysis (HP:0003090)2.14889617
54Embryonal renal neoplasm (HP:0011794)2.13779938
55Bone marrow hypocellularity (HP:0005528)2.13651729
56Ectopic kidney (HP:0000086)2.11872892
57Hyperglycinemia (HP:0002154)2.10189421
58Duplicated collecting system (HP:0000081)2.09976991
59Proximal placement of thumb (HP:0009623)2.06414480
60Triphalangeal thumb (HP:0001199)2.06089665
61Slender long bone (HP:0003100)2.06045849
62Poikiloderma (HP:0001029)2.05849183
63Overriding aorta (HP:0002623)2.05418427
64Type I transferrin isoform profile (HP:0003642)2.04033854
65Chromsome breakage (HP:0040012)2.03992580
66Ureteral duplication (HP:0000073)2.02817641
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.02292479
68Aplasia/Hypoplasia of the sternum (HP:0006714)2.01770547
69Facial cleft (HP:0002006)1.99964703
70Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99842248
71Deviation of the thumb (HP:0009603)1.98372089
72Basal cell carcinoma (HP:0002671)1.98017736
73Poor head control (HP:0002421)1.96843867
74Absent thumb (HP:0009777)1.95991567
75Secondary amenorrhea (HP:0000869)1.94544074
76Abnormality of the preputium (HP:0100587)1.94531392
77Abnormality of serine family amino acid metabolism (HP:0010894)1.94091125
78Abnormality of glycine metabolism (HP:0010895)1.94091125
79Atresia of the external auditory canal (HP:0000413)1.94080192
80Cutaneous melanoma (HP:0012056)1.93719340
81Lymphoma (HP:0002665)1.92396432
82Elevated erythrocyte sedimentation rate (HP:0003565)1.92361696
83Osteolytic defects of the phalanges of the hand (HP:0009771)1.92205209
84Osteolytic defects of the hand bones (HP:0009699)1.92205209
85Myelodysplasia (HP:0002863)1.90994068
86* Abnormality of the umbilical cord (HP:0010881)1.90424034
87Abnormal umbilical cord blood vessels (HP:0011403)1.90408083
88Single umbilical artery (HP:0001195)1.90408083
89Abnormality of the fetal cardiovascular system (HP:0010948)1.90408083
90Morphological abnormality of the inner ear (HP:0011390)1.89335985
91Abnormality of the renal collecting system (HP:0004742)1.88927537
92Abnormal protein glycosylation (HP:0012346)1.88789706
93Abnormal glycosylation (HP:0012345)1.88789706
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88789706
95Abnormal protein N-linked glycosylation (HP:0012347)1.88789706
96Biconcave vertebral bodies (HP:0004586)1.88685187
97Increased nuchal translucency (HP:0010880)1.88438796
98Absent radius (HP:0003974)1.88182379
99Shallow orbits (HP:0000586)1.87559997
100Meckel diverticulum (HP:0002245)1.87489907
101Bilateral microphthalmos (HP:0007633)1.87296961
102Turricephaly (HP:0000262)1.87223032
103Missing ribs (HP:0000921)1.86840337
104Asplenia (HP:0001746)1.86119296
105Chromosomal breakage induced by crosslinking agents (HP:0003221)1.84762788
106Abnormality of glycolysis (HP:0004366)1.84725023
107Increased serum pyruvate (HP:0003542)1.84725023
108Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.84473425
109Hepatoblastoma (HP:0002884)1.84398596
110Trigonocephaly (HP:0000243)1.84306194
111Hyperacusis (HP:0010780)1.83976667
112Abnormality of chromosome stability (HP:0003220)1.83608154
113Medulloblastoma (HP:0002885)1.82428433
114Absent forearm bone (HP:0003953)1.81701077
115Aplasia involving forearm bones (HP:0009822)1.81701077
116Abnormal number of incisors (HP:0011064)1.80653668
117Abnormality of the ileum (HP:0001549)1.80570840
118Aplasia/Hypoplasia of the spleen (HP:0010451)1.77832801
119Long foot (HP:0001833)1.77064908
120Renal duplication (HP:0000075)1.75990043
121Abnormality of the carotid arteries (HP:0005344)1.75213055
122Ependymoma (HP:0002888)1.75108079
123Esophageal atresia (HP:0002032)1.74891411
124Generalized hypotonia (HP:0001290)1.73836946
125Hyperglycinuria (HP:0003108)1.72753957
126Muscle fiber atrophy (HP:0100295)1.72402542
127Abnormal lung lobation (HP:0002101)1.70045169
128Soft skin (HP:0000977)1.69596169
129Delayed cranial suture closure (HP:0000270)1.69556151
130Impulsivity (HP:0100710)1.69032335
131Premature ovarian failure (HP:0008209)1.68170676
132Broad thumb (HP:0011304)1.67945140
133* Abnormality of the calcaneus (HP:0008364)1.67859663
134Horseshoe kidney (HP:0000085)1.67623929
135Cellular immunodeficiency (HP:0005374)1.67610117
136Ulnar bowing (HP:0003031)1.67370659
137Absent epiphyses (HP:0010577)1.67195928
138Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.67195928
139Preauricular skin tag (HP:0000384)1.67133191
140Sparse eyelashes (HP:0000653)1.66831992
141Bifid tongue (HP:0010297)1.66597348
142Hypoplasia of the pons (HP:0012110)1.66465877
143Aplasia/Hypoplasia of the breasts (HP:0010311)1.65640688
144Neoplasm of the adrenal cortex (HP:0100641)1.62420513
145Pseudobulbar signs (HP:0002200)1.62292563
146Abnormality of homocysteine metabolism (HP:0010919)1.62165753
147Homocystinuria (HP:0002156)1.62165753
148Breech presentation (HP:0001623)1.61955761
149Upper limb muscle weakness (HP:0003484)1.60915954
150Hemivertebrae (HP:0002937)1.59547685
151Embryonal neoplasm (HP:0002898)1.59264657
152Small intestinal stenosis (HP:0012848)1.58601572
153Duodenal stenosis (HP:0100867)1.58601572
154Abnormality of serum amino acid levels (HP:0003112)1.57840463
155Maternal diabetes (HP:0009800)1.55660168
156Broad phalanges of the hand (HP:0009768)1.55129793
157Insomnia (HP:0100785)1.54830203
158Short thumb (HP:0009778)1.52708524
159Long palpebral fissure (HP:0000637)1.50698612
160Absent septum pellucidum (HP:0001331)1.50082067

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.45510711
2WEE14.28566062
3VRK23.87992290
4SMG13.24548987
5TESK23.07438984
6CDC72.93344016
7TSSK62.89097166
8EEF2K2.77839613
9NME22.54719746
10STK162.53849970
11TAF12.38625893
12EIF2AK32.32788928
13EIF2AK12.30912407
14NEK22.14152386
15SCYL21.95000127
16RPS6KB21.80706044
17BRSK21.80295503
18PASK1.73343287
19TTK1.73207464
20TRIB31.71250361
21EPHA21.65495301
22LRRK21.61618363
23MKNK11.59246069
24PRKD31.57946610
25MAP3K81.57339267
26VRK11.48637419
27STK101.48087884
28PLK11.43249877
29SRPK11.41465898
30CDK71.40937420
31PIM21.39739019
32PAK41.39529577
33NEK11.32886300
34ACVR1B1.32596969
35AURKB1.32118701
36DYRK21.31289177
37PLK41.29778086
38DYRK31.29335993
39TLK11.29282604
40ATR1.28665692
41BRSK11.28144425
42RPS6KA41.27536358
43BCKDK1.24076396
44MAP4K11.23594629
45ICK1.20572884
46CDK121.17647140
47CDK41.14592181
48PKN21.14591166
49LATS21.06089596
50MAP3K101.05588082
51FLT31.05583375
52PLK31.04825555
53NME11.02043346
54CLK11.01891676
55CAMK1D0.98770662
56AURKA0.97048341
57PAK10.96580188
58CAMK1G0.94856137
59TESK10.93842540
60CHEK10.91808422
61TGFBR10.89683561
62CHEK20.86975269
63LIMK10.86825577
64ILK0.85679750
65PAK20.85047662
66CCNB10.82878115
67BRAF0.81154110
68NTRK10.77597647
69BTK0.75923087
70CSF1R0.75049719
71CDK190.75029286
72PNCK0.72677930
73ARAF0.70114338
74NUAK10.69058293
75KIT0.68804580
76MAP3K90.68540877
77MAPKAPK50.67697683
78MST40.67641657
79ZAP700.66486500
80DAPK10.65679335
81MKNK20.65646897
82ZAK0.65012212
83CDK150.63852907
84FGFR10.63287116
85FGFR20.62799382
86CSNK1G30.62193250
87STK40.61469934
88CDK180.61210309
89CSNK1E0.60155902
90LMTK20.59680691
91KDR0.59373594
92CDK140.58750017
93ERBB40.58568137
94CDK20.57041734
95ALK0.56627985
96PRKDC0.56181342
97LATS10.55992162
98CSNK2A20.53523091
99RPS6KA50.53404309
100TYRO30.53084022
101CDK90.53025370
102MAP2K30.52999377
103MAP2K20.52366638
104PLK20.48958625
105TNIK0.48384378
106PIM10.47872451
107JAK30.47451927
108PRKCI0.46682516
109CSNK2A10.46196616
110PDGFRA0.45506710
111TTN0.43466528
112MET0.43076100
113AKT20.42557341
114CSNK1A1L0.42405637
115CSNK1G20.41353884
116IRAK30.41109860
117PTK20.38937639
118CDK10.38446706
119MTOR0.37892430
120EIF2AK20.37857169
121MAP3K110.37791291
122UHMK10.36906999
123BRD40.36568297
124ATM0.36461849
125CDK60.35513390
126DAPK30.34792760
127MELK0.34705145
128TEC0.34526411
129BMX0.34307030
130CDK80.34228417
131GRK60.32898716
132CSNK1G10.31969475
133PBK0.31524709
134ERN10.31107665
135SIK10.29071593
136MAPKAPK20.26630799
137CDK11A0.26341265
138RAF10.24771532

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.95877774
2Mismatch repair_Homo sapiens_hsa034303.78276773
3Ribosome_Homo sapiens_hsa030103.50912248
4Proteasome_Homo sapiens_hsa030503.34319996
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.22539110
6Base excision repair_Homo sapiens_hsa034103.09272161
7Spliceosome_Homo sapiens_hsa030403.03054948
8RNA polymerase_Homo sapiens_hsa030202.96075927
9RNA transport_Homo sapiens_hsa030132.76099170
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.73322915
11One carbon pool by folate_Homo sapiens_hsa006702.67855950
12Nucleotide excision repair_Homo sapiens_hsa034202.66521932
13Homologous recombination_Homo sapiens_hsa034402.57715943
14Cell cycle_Homo sapiens_hsa041102.45663229
15Pyrimidine metabolism_Homo sapiens_hsa002402.29050177
16Vitamin B6 metabolism_Homo sapiens_hsa007502.21913403
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.76526927
18Non-homologous end-joining_Homo sapiens_hsa034501.69338805
19Fanconi anemia pathway_Homo sapiens_hsa034601.59363224
20Pyruvate metabolism_Homo sapiens_hsa006201.50044455
21p53 signaling pathway_Homo sapiens_hsa041151.47589246
22Pentose phosphate pathway_Homo sapiens_hsa000301.45226481
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43402049
24RNA degradation_Homo sapiens_hsa030181.41802392
25Protein export_Homo sapiens_hsa030601.33500667
26Folate biosynthesis_Homo sapiens_hsa007901.30389582
27Basal transcription factors_Homo sapiens_hsa030221.27240565
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26004527
29Purine metabolism_Homo sapiens_hsa002301.21431806
30Sulfur relay system_Homo sapiens_hsa041221.21284223
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16836271
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14454146
33Systemic lupus erythematosus_Homo sapiens_hsa053221.11307107
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10188258
35mRNA surveillance pathway_Homo sapiens_hsa030151.09812852
36N-Glycan biosynthesis_Homo sapiens_hsa005101.08244402
37Epstein-Barr virus infection_Homo sapiens_hsa051691.07850273
38* Biosynthesis of amino acids_Homo sapiens_hsa012301.06331804
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.04883186
40Antigen processing and presentation_Homo sapiens_hsa046121.04278633
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02428515
42Viral carcinogenesis_Homo sapiens_hsa052030.99646396
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.97396656
44Lysine degradation_Homo sapiens_hsa003100.94544305
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93463653
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93046029
47Arginine biosynthesis_Homo sapiens_hsa002200.88458648
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88358841
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87392632
50* Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81284651
51Primary immunodeficiency_Homo sapiens_hsa053400.77733689
52Propanoate metabolism_Homo sapiens_hsa006400.77409852
53Parkinsons disease_Homo sapiens_hsa050120.77178914
54Huntingtons disease_Homo sapiens_hsa050160.75873362
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74332708
56Hedgehog signaling pathway_Homo sapiens_hsa043400.73846149
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70819092
58Small cell lung cancer_Homo sapiens_hsa052220.70798469
59Wnt signaling pathway_Homo sapiens_hsa043100.69225614
60HTLV-I infection_Homo sapiens_hsa051660.69170284
61Glutathione metabolism_Homo sapiens_hsa004800.68290752
62Fatty acid metabolism_Homo sapiens_hsa012120.65774466
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65762630
64Herpes simplex infection_Homo sapiens_hsa051680.63404379
65Selenocompound metabolism_Homo sapiens_hsa004500.63235862
66Oocyte meiosis_Homo sapiens_hsa041140.59268388
67Adherens junction_Homo sapiens_hsa045200.58938657
68Legionellosis_Homo sapiens_hsa051340.58318109
69Shigellosis_Homo sapiens_hsa051310.57931584
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56179650
71Oxidative phosphorylation_Homo sapiens_hsa001900.54171916
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53109260
73* Carbon metabolism_Homo sapiens_hsa012000.52960346
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51997590
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51466104
76Thyroid cancer_Homo sapiens_hsa052160.50706822
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47414351
78Apoptosis_Homo sapiens_hsa042100.45948169
79MicroRNAs in cancer_Homo sapiens_hsa052060.44262149
80Steroid biosynthesis_Homo sapiens_hsa001000.43624748
81Renin-angiotensin system_Homo sapiens_hsa046140.43089617
82Fructose and mannose metabolism_Homo sapiens_hsa000510.43038873
83Tight junction_Homo sapiens_hsa045300.42727385
84Arginine and proline metabolism_Homo sapiens_hsa003300.41416790
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.41405842
86Notch signaling pathway_Homo sapiens_hsa043300.38847058
87Alcoholism_Homo sapiens_hsa050340.37853154
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35491085
89Fatty acid elongation_Homo sapiens_hsa000620.35190829
90Chronic myeloid leukemia_Homo sapiens_hsa052200.34014795
91Vitamin digestion and absorption_Homo sapiens_hsa049770.32976884
92Alzheimers disease_Homo sapiens_hsa050100.32912959
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32827752
94Bladder cancer_Homo sapiens_hsa052190.32743572
95Melanogenesis_Homo sapiens_hsa049160.31857903
96Phenylalanine metabolism_Homo sapiens_hsa003600.31418624
97Measles_Homo sapiens_hsa051620.30507773
98Prostate cancer_Homo sapiens_hsa052150.30372531
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30254346
100beta-Alanine metabolism_Homo sapiens_hsa004100.28968288
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.27927443
102* Metabolic pathways_Homo sapiens_hsa011000.27595982
103Glucagon signaling pathway_Homo sapiens_hsa049220.27471996
104Hepatitis B_Homo sapiens_hsa051610.27387955
105Fatty acid degradation_Homo sapiens_hsa000710.26321931
106Other glycan degradation_Homo sapiens_hsa005110.25739858
107Melanoma_Homo sapiens_hsa052180.25426162
108Hippo signaling pathway_Homo sapiens_hsa043900.25172689
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25079460
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23636473
111Tyrosine metabolism_Homo sapiens_hsa003500.23559880
112Basal cell carcinoma_Homo sapiens_hsa052170.23425271
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.23080525
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23014003
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23009236
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.22547407
117Fatty acid biosynthesis_Homo sapiens_hsa000610.22490228
118TGF-beta signaling pathway_Homo sapiens_hsa043500.22068479
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21811499
120Pathways in cancer_Homo sapiens_hsa052000.20676493
121AMPK signaling pathway_Homo sapiens_hsa041520.20402969
122Colorectal cancer_Homo sapiens_hsa052100.19448816
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19423029
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19397956
125Protein digestion and absorption_Homo sapiens_hsa049740.18406560
126Galactose metabolism_Homo sapiens_hsa000520.17933081
127Acute myeloid leukemia_Homo sapiens_hsa052210.16985881
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16793628
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16292265
130HIF-1 signaling pathway_Homo sapiens_hsa040660.15971382
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15309447
132Viral myocarditis_Homo sapiens_hsa054160.14658548
133Hematopoietic cell lineage_Homo sapiens_hsa046400.14013241
134Regulation of autophagy_Homo sapiens_hsa041400.13707738
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13367682
136B cell receptor signaling pathway_Homo sapiens_hsa046620.12619725

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