PHIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that binds to the insulin receptor substrate 1 protein and regulates glucose transporter translocation in skeletal muscle cells. The encoded protein may also regulate growth and survival of pancreatic beta cells. Elevated copy number of this gene may be associated with melanoma severity and the encoded protein may promote melanoma metastasis in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)4.79649141
2regulation of DNA endoreduplication (GO:0032875)4.18732377
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.18475588
4histone H3-K4 trimethylation (GO:0080182)3.75068856
5kinetochore organization (GO:0051383)3.52107062
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.49477288
7DNA topological change (GO:0006265)3.47158029
8monoubiquitinated protein deubiquitination (GO:0035520)3.47004950
9intraciliary transport (GO:0042073)3.42671568
10nuclear pore complex assembly (GO:0051292)3.40504994
11interkinetic nuclear migration (GO:0022027)3.39903757
12DNA double-strand break processing (GO:0000729)3.36292693
13pyrimidine nucleobase catabolic process (GO:0006208)3.34531839
14negative regulation of DNA-dependent DNA replication (GO:2000104)3.27158973
15histone H3-K36 demethylation (GO:0070544)3.25570085
16negative regulation of histone methylation (GO:0031061)3.23941242
17regulation of histone H3-K9 methylation (GO:0051570)3.22000625
18negative regulation of translation, ncRNA-mediated (GO:0040033)3.21547234
19regulation of translation, ncRNA-mediated (GO:0045974)3.21547234
20negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.21547234
21presynaptic membrane assembly (GO:0097105)3.20265936
22olfactory bulb development (GO:0021772)3.19538683
23cell proliferation in forebrain (GO:0021846)3.18650718
24mitotic chromosome condensation (GO:0007076)3.13678263
25peptidyl-lysine trimethylation (GO:0018023)3.11659422
26synapsis (GO:0007129)3.10692580
27mRNA splice site selection (GO:0006376)3.05642225
28negative regulation of DNA recombination (GO:0045910)3.05128581
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.02754548
30histone H3-K9 methylation (GO:0051567)3.02480764
31histone exchange (GO:0043486)3.02313016
32histone H2A acetylation (GO:0043968)3.00894119
33cerebral cortex radially oriented cell migration (GO:0021799)2.99855866
34nuclear pore organization (GO:0006999)2.99597058
35regulation of centriole replication (GO:0046599)2.97291617
36ncRNA catabolic process (GO:0034661)2.94568080
37recombinational repair (GO:0000725)2.94411154
38presynaptic membrane organization (GO:0097090)2.92756020
39double-strand break repair via homologous recombination (GO:0000724)2.92734538
40somatic diversification of immune receptors via somatic mutation (GO:0002566)2.92324543
41somatic hypermutation of immunoglobulin genes (GO:0016446)2.92324543
42histone H3-K4 methylation (GO:0051568)2.91761404
43positive regulation of histone H3-K4 methylation (GO:0051571)2.83270390
44centriole replication (GO:0007099)2.83225614
45microtubule organizing center organization (GO:0031023)2.82864526
46behavioral response to nicotine (GO:0035095)2.81428411
47DNA unwinding involved in DNA replication (GO:0006268)2.80875799
48microtubule depolymerization (GO:0007019)2.80447569
49reciprocal DNA recombination (GO:0035825)2.80274093
50reciprocal meiotic recombination (GO:0007131)2.80274093
51limb bud formation (GO:0060174)2.77287177
52histone mRNA catabolic process (GO:0071044)2.77278248
53kinetochore assembly (GO:0051382)2.74899839
54centrosome organization (GO:0051297)2.74200359
55dosage compensation (GO:0007549)2.67535919
56cytoplasmic mRNA processing body assembly (GO:0033962)2.66446834
57positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.66208576
58positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.66208576
59positive regulation of mitotic sister chromatid separation (GO:1901970)2.66208576
60otic vesicle formation (GO:0030916)2.66186786
61regulation of RNA export from nucleus (GO:0046831)2.64569589
62nucleobase catabolic process (GO:0046113)2.64321136
63regulation of histone methylation (GO:0031060)2.63667664
64histone H3-K9 modification (GO:0061647)2.63116898
65sister chromatid segregation (GO:0000819)2.62740754
66pore complex assembly (GO:0046931)2.62160553
67non-recombinational repair (GO:0000726)2.60516906
68double-strand break repair via nonhomologous end joining (GO:0006303)2.60516906
69pre-miRNA processing (GO:0031054)2.60158703
70histone H3-K9 demethylation (GO:0033169)2.59939176
71histone lysine demethylation (GO:0070076)2.59471852
72histone lysine methylation (GO:0034968)2.59325960
73sister chromatid cohesion (GO:0007062)2.56724711
74replicative senescence (GO:0090399)2.55094833
75regulation of centrosome duplication (GO:0010824)2.54918767
76cilium organization (GO:0044782)2.54409854
77histone H4-K16 acetylation (GO:0043984)2.53244156
78protein prenylation (GO:0018342)2.53227482
79prenylation (GO:0097354)2.53227482
80regulation of mitotic spindle checkpoint (GO:1903504)2.52848510
81regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.52848510
82regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.52814710
83translesion synthesis (GO:0019985)2.51925490
84rRNA catabolic process (GO:0016075)2.51409436
85regulation of helicase activity (GO:0051095)2.50218333
86nucleus localization (GO:0051647)2.49965824
87cilium assembly (GO:0042384)2.49734674
88histone demethylation (GO:0016577)2.49428562
89forebrain neuron differentiation (GO:0021879)2.49056503
90centrosome duplication (GO:0051298)2.48378919
91spindle checkpoint (GO:0031577)2.47931845
92protein K11-linked deubiquitination (GO:0035871)2.47884571
93hindbrain development (GO:0030902)2.47704057
94positive regulation of histone methylation (GO:0031062)2.47699594
95retinal ganglion cell axon guidance (GO:0031290)2.47186481
96regulation of meiosis I (GO:0060631)2.45958484
97intra-S DNA damage checkpoint (GO:0031573)2.45568770
98regulation of telomere maintenance (GO:0032204)2.45383675
99nonmotile primary cilium assembly (GO:0035058)2.44281881
100regulation of sister chromatid segregation (GO:0033045)2.43940406
101regulation of mitotic sister chromatid separation (GO:0010965)2.43940406
102regulation of mitotic sister chromatid segregation (GO:0033047)2.43940406
103negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.42906581
104negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.42906581
105negative regulation of mitotic sister chromatid segregation (GO:0033048)2.42906581
106negative regulation of mitotic sister chromatid separation (GO:2000816)2.42906581
107negative regulation of sister chromatid segregation (GO:0033046)2.42906581
108meiotic chromosome segregation (GO:0045132)2.41867306
109regulation of histone H3-K4 methylation (GO:0051569)2.39209329
110protein-DNA complex disassembly (GO:0032986)2.38904674
111nucleosome disassembly (GO:0006337)2.38904674
112replication fork processing (GO:0031297)2.38728075
113V(D)J recombination (GO:0033151)2.38239243
114microtubule anchoring (GO:0034453)2.35851438
115peptidyl-lysine methylation (GO:0018022)2.34780494
116regulation of sister chromatid cohesion (GO:0007063)2.34560554
117resolution of meiotic recombination intermediates (GO:0000712)2.34110703
118DNA strand renaturation (GO:0000733)2.33549606
119protein localization to kinetochore (GO:0034501)2.29737581
120regulation of histone H3-K27 methylation (GO:0061085)2.27309516
121positive regulation of cell cycle checkpoint (GO:1901978)2.26369668
122definitive hemopoiesis (GO:0060216)2.26296971
123centriole assembly (GO:0098534)2.24636608
124pyrimidine dimer repair (GO:0006290)2.23766526
125DNA geometric change (GO:0032392)2.23617105
126negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.21050258
127DNA duplex unwinding (GO:0032508)2.20777498
128CENP-A containing nucleosome assembly (GO:0034080)2.19741733
129DNA replication-independent nucleosome organization (GO:0034724)2.18659338
130DNA replication-independent nucleosome assembly (GO:0006336)2.18659338
131ganglion development (GO:0061548)2.17404311
132maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.16648401
133histone methylation (GO:0016571)2.15383830
134regulation of mRNA splicing, via spliceosome (GO:0048024)2.15098975
135negative regulation of cell cycle G2/M phase transition (GO:1902750)2.14711194
136embryonic camera-type eye morphogenesis (GO:0048596)2.14582392
137B cell homeostasis (GO:0001782)2.13936797
138DNA synthesis involved in DNA repair (GO:0000731)2.13783543
139ATP-dependent chromatin remodeling (GO:0043044)2.13025144
140chromatin assembly (GO:0031497)2.12944067
141protein dealkylation (GO:0008214)2.12853370
142protein demethylation (GO:0006482)2.12853370
143negative regulation of DNA repair (GO:0045738)2.11609836
144neural tube formation (GO:0001841)2.11290680
145regulation of telomere maintenance via telomerase (GO:0032210)2.11277089
146establishment of mitotic spindle orientation (GO:0000132)2.11130017
147regulation of centrosome cycle (GO:0046605)2.11038862
148pericardium development (GO:0060039)2.10644388
149alternative mRNA splicing, via spliceosome (GO:0000380)2.10281288
150DNA ligation (GO:0006266)2.09825271
151chromatin remodeling at centromere (GO:0031055)2.09791109
152DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.07934513
153attachment of spindle microtubules to kinetochore (GO:0008608)2.06973738
154chromatin assembly or disassembly (GO:0006333)2.05577138
155regulation of nuclear cell cycle DNA replication (GO:0033262)2.05575644
156establishment of mitotic spindle localization (GO:0040001)2.04929560
157nucleosome organization (GO:0034728)2.04758230

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.69281834
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.32572324
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.01298541
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.41425690
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.38821532
6* SALL1_21062744_ChIP-ChIP_HESCs_Human3.14877496
7* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.95481440
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.83416367
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.77514714
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.41356088
11ZNF274_21170338_ChIP-Seq_K562_Hela2.34672526
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.29778988
13* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29583073
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.22452665
15FUS_26573619_Chip-Seq_HEK293_Human2.15877157
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.09942459
17GBX2_23144817_ChIP-Seq_PC3_Human2.03349859
18VDR_22108803_ChIP-Seq_LS180_Human1.97185146
19EWS_26573619_Chip-Seq_HEK293_Human1.93317522
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92832625
21IGF1R_20145208_ChIP-Seq_DFB_Human1.86696467
22EZH2_22144423_ChIP-Seq_EOC_Human1.80953704
23IRF1_19129219_ChIP-ChIP_H3396_Human1.77317169
24HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74166914
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.73286995
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72860082
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69766642
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.63351215
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58624178
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.56885949
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48807321
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48604580
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.48559306
34RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.46651984
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43654359
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40196045
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40145866
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39319640
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39290061
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39123260
41P300_19829295_ChIP-Seq_ESCs_Human1.38510556
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33559262
43TAF15_26573619_Chip-Seq_HEK293_Human1.33541168
44CBP_20019798_ChIP-Seq_JUKART_Human1.32989783
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32989783
46TP53_16413492_ChIP-PET_HCT116_Human1.31737993
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31645696
48FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.30091765
49ELK1_19687146_ChIP-ChIP_HELA_Human1.29536308
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28511213
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27528480
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27528480
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27240882
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.26154815
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.25624545
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24751008
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24624131
58AR_25329375_ChIP-Seq_VCAP_Human1.24428256
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.24169462
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.23531958
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21796988
62* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20393469
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20243605
64RUNX2_22187159_ChIP-Seq_PCA_Human1.19105194
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17792228
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17662427
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16582729
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16282731
69PKCTHETA_26484144_Chip-Seq_BREAST_Human1.15716528
70AR_21572438_ChIP-Seq_LNCaP_Human1.15117339
71MYC_18940864_ChIP-ChIP_HL60_Human1.14905011
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.14330539
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13538501
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11814090
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11664153
76BCAT_22108803_ChIP-Seq_LS180_Human1.11614442
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.11570317
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11446491
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10752477
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10053123
81SMAD4_21799915_ChIP-Seq_A2780_Human1.08341733
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08278917
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08096263
84* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06270440
85STAT3_23295773_ChIP-Seq_U87_Human1.06083991
86TCF4_23295773_ChIP-Seq_U87_Human1.05292559
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05250469
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04569597
89TCF4_22108803_ChIP-Seq_LS180_Human1.04294226
90EST1_17652178_ChIP-ChIP_JURKAT_Human1.03854121
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03563626
92* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02724289
93TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02561029
94TCF4_18268006_ChIP-ChIP_LS174T_Human1.02496475
95SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01352881
96* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00834815
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00329972
98P53_22387025_ChIP-Seq_ESCs_Mouse1.00077441
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99954546
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99251720
101CMYC_18555785_Chip-Seq_ESCs_Mouse0.98780601
102* BRD4_25478319_ChIP-Seq_HGPS_Human0.98198513
103ER_23166858_ChIP-Seq_MCF-7_Human0.98134531
104SMAD3_21741376_ChIP-Seq_EPCs_Human0.97932530
105PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97922464
106EZH2_27294783_Chip-Seq_NPCs_Mouse0.97861070
107CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96343027
108NOTCH1_21737748_ChIP-Seq_TLL_Human0.96195906
109RUNX_20019798_ChIP-Seq_JUKART_Human0.95630550
110SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95207328
111* SOX2_21211035_ChIP-Seq_LN229_Gbm0.94914328
112NFE2_27457419_Chip-Seq_LIVER_Mouse0.94626799
113CIITA_25753668_ChIP-Seq_RAJI_Human0.94109272
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93906416
115SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92703689
116* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92703337
117ARNT_22903824_ChIP-Seq_MCF-7_Human0.92290545
118YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91561563
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.90846541
120PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89951078
121TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89380597
122FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88507796
123P300_18555785_Chip-Seq_ESCs_Mouse0.88211127
124SOX9_26525672_Chip-Seq_HEART_Mouse0.88015291
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87777151
126* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87179591
127NMYC_18555785_Chip-Seq_ESCs_Mouse0.85582475
128CBX2_27304074_Chip-Seq_ESCs_Mouse0.85018989
129OCT4_18555785_Chip-Seq_ESCs_Mouse0.84882527
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84508259
131RNF2_27304074_Chip-Seq_NSC_Mouse0.83679401
132CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83561262
133EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.83542513

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.15776220
2MP0003787_abnormal_imprinting3.38535424
3MP0002009_preneoplasia2.97732453
4MP0003121_genomic_imprinting2.85827357
5MP0008057_abnormal_DNA_replication2.46646749
6MP0010094_abnormal_chromosome_stability2.37068198
7MP0003890_abnormal_embryonic-extraembry2.16228939
8MP0008058_abnormal_DNA_repair2.00235319
9MP0006292_abnormal_olfactory_placode1.95457786
10MP0002166_altered_tumor_susceptibility1.92083574
11MP0008877_abnormal_DNA_methylation1.86983486
12MP0003880_abnormal_central_pattern1.85975834
13MP0005174_abnormal_tail_pigmentation1.78842604
14MP0002938_white_spotting1.74141899
15MP0008007_abnormal_cellular_replicative1.72049633
16MP0003122_maternal_imprinting1.71006438
17MP0002102_abnormal_ear_morphology1.67922324
18MP0000566_synostosis1.67005380
19MP0003077_abnormal_cell_cycle1.63318886
20MP0003567_abnormal_fetal_cardiomyocyte1.60494038
21MP0000015_abnormal_ear_pigmentation1.54029080
22MP0002006_tumorigenesis1.50002531
23MP0008789_abnormal_olfactory_epithelium1.49699336
24MP0003111_abnormal_nucleus_morphology1.48028469
25MP0001529_abnormal_vocalization1.47090429
26MP0010307_abnormal_tumor_latency1.42407027
27MP0005645_abnormal_hypothalamus_physiol1.42226770
28MP0002095_abnormal_skin_pigmentation1.41797788
29MP0004808_abnormal_hematopoietic_stem1.41243310
30MP0003937_abnormal_limbs/digits/tail_de1.40560066
31MP0005076_abnormal_cell_differentiation1.37827537
32MP0004133_heterotaxia1.36432091
33MP0002163_abnormal_gland_morphology1.33670497
34MP0005394_taste/olfaction_phenotype1.32210325
35MP0005499_abnormal_olfactory_system1.32210325
36MP0005551_abnormal_eye_electrophysiolog1.31369634
37MP0001188_hyperpigmentation1.28040419
38MP0006072_abnormal_retinal_apoptosis1.26047211
39MP0002160_abnormal_reproductive_system1.24779262
40MP0001293_anophthalmia1.24525997
41MP0006276_abnormal_autonomic_nervous1.23987040
42MP0002234_abnormal_pharynx_morphology1.23554286
43MP0009697_abnormal_copulation1.22294182
44MP0002396_abnormal_hematopoietic_system1.21070882
45MP0003938_abnormal_ear_development1.19256133
46MP0003385_abnormal_body_wall1.18831453
47MP0003935_abnormal_craniofacial_develop1.18740482
48MP0003763_abnormal_thymus_physiology1.17132057
49MP0001485_abnormal_pinna_reflex1.16892995
50MP0010030_abnormal_orbit_morphology1.16888117
51MP0002177_abnormal_outer_ear1.16886109
52MP0005646_abnormal_pituitary_gland1.15485120
53MP0002184_abnormal_innervation1.15216718
54MP0000049_abnormal_middle_ear1.13609571
55MP0003123_paternal_imprinting1.13162275
56MP0001879_abnormal_lymphatic_vessel1.12411848
57MP0000631_abnormal_neuroendocrine_gland1.12345163
58MP0002277_abnormal_respiratory_mucosa1.12139604
59MP0001835_abnormal_antigen_presentation1.11142576
60MP0000383_abnormal_hair_follicle1.11054939
61MP0002638_abnormal_pupillary_reflex1.09528008
62MP0008995_early_reproductive_senescence1.08199332
63MP0004885_abnormal_endolymph1.07300572
64MP0002210_abnormal_sex_determination1.07097002
65MP0005171_absent_coat_pigmentation1.03863985
66MP0001486_abnormal_startle_reflex1.03862662
67MP0010352_gastrointestinal_tract_polyps1.03164525
68MP0000703_abnormal_thymus_morphology1.03033069
69MP0001929_abnormal_gametogenesis1.01170007
70MP0003943_abnormal_hepatobiliary_system1.00740659
71MP0001346_abnormal_lacrimal_gland0.99769360
72MP0001286_abnormal_eye_development0.99574538
73MP0005195_abnormal_posterior_eye0.99514516
74MP0000778_abnormal_nervous_system0.99444683
75MP0000955_abnormal_spinal_cord0.98796976
76MP0003755_abnormal_palate_morphology0.98273621
77MP0002152_abnormal_brain_morphology0.97177780
78MP0005409_darkened_coat_color0.97028444
79MP0001145_abnormal_male_reproductive0.96752410
80MP0002752_abnormal_somatic_nervous0.96020902
81MP0001800_abnormal_humoral_immune0.95523572
82MP0002653_abnormal_ependyma_morphology0.95522841
83MP0005187_abnormal_penis_morphology0.94661495
84MP0000653_abnormal_sex_gland0.94282437
85MP0000647_abnormal_sebaceous_gland0.94141402
86MP0005389_reproductive_system_phenotype0.93501864
87MP0003136_yellow_coat_color0.93228014
88MP0003698_abnormal_male_reproductive0.92873073
89MP0005253_abnormal_eye_physiology0.92806369
90MP0003941_abnormal_skin_development0.92805896
91MP0009703_decreased_birth_body0.92463695
92MP0000432_abnormal_head_morphology0.92359590
93MP0002557_abnormal_social/conspecific_i0.92327976
94MP0004134_abnormal_chest_morphology0.92201964
95MP0004142_abnormal_muscle_tone0.91514283
96MP0003119_abnormal_digestive_system0.90797855
97MP0002751_abnormal_autonomic_nervous0.90346149
98MP0001177_atelectasis0.89366858
99MP0003693_abnormal_embryo_hatching0.89314404
100MP0005379_endocrine/exocrine_gland_phen0.89202104
101MP0000427_abnormal_hair_cycle0.88971342
102MP0002877_abnormal_melanocyte_morpholog0.88616618
103MP0004957_abnormal_blastocyst_morpholog0.88429368
104MP0000516_abnormal_urinary_system0.87727408
105MP0005367_renal/urinary_system_phenotyp0.87727408
106MP0000428_abnormal_craniofacial_morphol0.87720867
107MP0001299_abnormal_eye_distance/0.87603052
108MP0006054_spinal_hemorrhage0.87572854
109MP0005391_vision/eye_phenotype0.87031083
110MP0002398_abnormal_bone_marrow0.86892898
111MP0005503_abnormal_tendon_morphology0.86384944
112MP0002233_abnormal_nose_morphology0.85636959
113MP0005671_abnormal_response_to0.85499120
114MP0002697_abnormal_eye_size0.84577712
115MP0002084_abnormal_developmental_patter0.84068850
116MP0000350_abnormal_cell_proliferation0.83248283
117MP0001324_abnormal_eye_pigmentation0.82527604
118MP0000371_diluted_coat_color0.81957908
119MP0002882_abnormal_neuron_morphology0.81829286
120MP0004742_abnormal_vestibular_system0.81632732
121MP0000733_abnormal_muscle_development0.81581457
122MP0002075_abnormal_coat/hair_pigmentati0.81436201
123MP0004811_abnormal_neuron_physiology0.79963470
124MP0010678_abnormal_skin_adnexa0.79865527
125MP0002452_abnormal_antigen_presenting0.79273123
126MP0002085_abnormal_embryonic_tissue0.78959270
127MP0001186_pigmentation_phenotype0.78703183
128MP0005248_abnormal_Harderian_gland0.77304000
129MP0002116_abnormal_craniofacial_bone0.76632988
130MP0002092_abnormal_eye_morphology0.76527747
131MP0002272_abnormal_nervous_system0.75540798
132MP0003861_abnormal_nervous_system0.75353414
133MP0009046_muscle_twitch0.75099709
134MP0005387_immune_system_phenotype0.74858278
135MP0001790_abnormal_immune_system0.74858278
136MP0001119_abnormal_female_reproductive0.74550410
137MP0001984_abnormal_olfaction0.74241013
138MP0002109_abnormal_limb_morphology0.73999109
139MP0008932_abnormal_embryonic_tissue0.73802458
140MP0002081_perinatal_lethality0.73770556
141MP0004924_abnormal_behavior0.73527272
142MP0003183_abnormal_peptide_metabolism0.72856595
143MP0004197_abnormal_fetal_growth/weight/0.72776260
144MP0003300_gastrointestinal_ulcer0.71037515
145MP0002928_abnormal_bile_duct0.70161382
146MP0003115_abnormal_respiratory_system0.69848278

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.16851837
2Abnormality of the fingertips (HP:0001211)3.55055685
3Abnormality of the labia minora (HP:0012880)3.09008852
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.02323367
5Short 4th metacarpal (HP:0010044)3.02323367
6Pancreatic fibrosis (HP:0100732)2.99916137
7Nephronophthisis (HP:0000090)2.93783825
8Chromsome breakage (HP:0040012)2.81041717
9True hermaphroditism (HP:0010459)2.80274893
10Abnormality of midbrain morphology (HP:0002418)2.74848665
11Molar tooth sign on MRI (HP:0002419)2.74848665
12Pancreatic cysts (HP:0001737)2.74554154
13Chromosomal breakage induced by crosslinking agents (HP:0003221)2.72400273
14Abnormality of the renal medulla (HP:0100957)2.68461386
15Hepatoblastoma (HP:0002884)2.64404923
16Hyperventilation (HP:0002883)2.64236102
17Midline defect of the nose (HP:0004122)2.54817469
18Thyroiditis (HP:0100646)2.53561417
19Lip pit (HP:0100267)2.53489546
20Medial flaring of the eyebrow (HP:0010747)2.49725364
21Absent frontal sinuses (HP:0002688)2.42237975
22Ectopic kidney (HP:0000086)2.41722133
23Aqueductal stenosis (HP:0002410)2.38852658
24Spinal cord lesions (HP:0100561)2.37882932
25Syringomyelia (HP:0003396)2.37882932
26Drooling (HP:0002307)2.37352059
27Genital tract atresia (HP:0001827)2.29426335
28Postaxial foot polydactyly (HP:0001830)2.25334257
29Sloping forehead (HP:0000340)2.22734256
30Abnormality of the nasal septum (HP:0000419)2.22510605
31Congenital primary aphakia (HP:0007707)2.22030176
32Gait imbalance (HP:0002141)2.21857609
33Macroorchidism (HP:0000053)2.19949805
34Vaginal atresia (HP:0000148)2.19941210
35Abnormality of chromosome stability (HP:0003220)2.17142355
36Oligodactyly (HP:0012165)2.16861994
37Nephrogenic diabetes insipidus (HP:0009806)2.16607039
38Excessive salivation (HP:0003781)2.14078929
39Poor coordination (HP:0002370)2.11839356
40Aplasia/Hypoplasia of the tongue (HP:0010295)2.11589810
41Obsessive-compulsive behavior (HP:0000722)2.11274673
42Abnormality of the renal cortex (HP:0011035)2.09886584
43Truncal obesity (HP:0001956)2.08853597
44Long eyelashes (HP:0000527)2.06547537
45Papillary thyroid carcinoma (HP:0002895)2.04889344
46Intestinal atresia (HP:0011100)2.03272765
47Septo-optic dysplasia (HP:0100842)2.00860151
48Deep philtrum (HP:0002002)1.99069176
49Postaxial hand polydactyly (HP:0001162)1.98672943
50Medulloblastoma (HP:0002885)1.97169442
51Hip dysplasia (HP:0001385)1.96953013
52Abnormal lung lobation (HP:0002101)1.96839139
53Broad-based gait (HP:0002136)1.95891318
54Growth hormone deficiency (HP:0000824)1.93575643
55Colon cancer (HP:0003003)1.92056000
56Rhabdomyosarcoma (HP:0002859)1.91863655
57High anterior hairline (HP:0009890)1.91050804
58Gastrointestinal atresia (HP:0002589)1.90332283
59Acute myeloid leukemia (HP:0004808)1.90241286
60Aplasia/Hypoplasia of the uvula (HP:0010293)1.89613232
61Cupped ear (HP:0000378)1.86850593
62Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.86691758
63Narrow forehead (HP:0000341)1.86575782
64Rib fusion (HP:0000902)1.86146174
65Optic nerve hypoplasia (HP:0000609)1.85710782
66Transitional cell carcinoma of the bladder (HP:0006740)1.85311566
67Abnormality of the incisor (HP:0000676)1.85083474
68Neoplasm of the adrenal cortex (HP:0100641)1.83805149
69Bifid tongue (HP:0010297)1.83656535
70Triphalangeal thumb (HP:0001199)1.82486477
71Protruding tongue (HP:0010808)1.82166601
72Anophthalmia (HP:0000528)1.81861173
73Genetic anticipation (HP:0003743)1.81361639
74Narrow palate (HP:0000189)1.79800173
75Abnormality of the duodenum (HP:0002246)1.79547293
76Asymmetry of the thorax (HP:0001555)1.79206331
77Dandy-Walker malformation (HP:0001305)1.78580358
78Patellar aplasia (HP:0006443)1.78326229
79Nephroblastoma (Wilms tumor) (HP:0002667)1.78127012
80Hypoplasia of the maxilla (HP:0000327)1.78074404
81Abnormality of the preputium (HP:0100587)1.77448545
82Labial hypoplasia (HP:0000066)1.76414963
83Duodenal stenosis (HP:0100867)1.76165843
84Small intestinal stenosis (HP:0012848)1.76165843
85Astigmatism (HP:0000483)1.75671644
86Abnormality of the 4th metacarpal (HP:0010012)1.75585295
87Increased number of teeth (HP:0011069)1.75223405
88Thick eyebrow (HP:0000574)1.74783765
89Abnormality of the antihelix (HP:0009738)1.74561189
90Anencephaly (HP:0002323)1.73801199
91Sclerocornea (HP:0000647)1.73517976
92Anal stenosis (HP:0002025)1.72780836
93Cystic liver disease (HP:0006706)1.72743803
94Embryonal renal neoplasm (HP:0011794)1.72688158
95Abnormality of the right ventricle (HP:0001707)1.71283903
96Facial hemangioma (HP:0000329)1.70134643
97Abnormality of the labia majora (HP:0012881)1.70028406
98Broad foot (HP:0001769)1.69938371
99Renal hypoplasia (HP:0000089)1.69649741
100Increased nuchal translucency (HP:0010880)1.69142287
101Hypoplastic iliac wings (HP:0002866)1.69106403
102Ependymoma (HP:0002888)1.69020127
103Micropenis (HP:0000054)1.68611156
104Agammaglobulinemia (HP:0004432)1.68075284
105Abnormality of chromosome segregation (HP:0002916)1.67894301
106Abnormality of the columella (HP:0009929)1.66918402
107Hypoplastic female external genitalia (HP:0012815)1.66827187
108Inappropriate behavior (HP:0000719)1.66415382
109Trigonocephaly (HP:0000243)1.65465368
110Abnormality of incisor morphology (HP:0011063)1.65350770
111Tented upper lip vermilion (HP:0010804)1.65123338
112Thin upper lip vermilion (HP:0000219)1.65105123
113Prominent nasal bridge (HP:0000426)1.65096627
114Leiomyosarcoma (HP:0100243)1.65000758
115Uterine leiomyosarcoma (HP:0002891)1.65000758
116Abnormal number of incisors (HP:0011064)1.64834920
117Abnormality of the renal collecting system (HP:0004742)1.64781028
118Oligodactyly (hands) (HP:0001180)1.64254088
119Lissencephaly (HP:0001339)1.63568141
120Hypoplastic labia majora (HP:0000059)1.63496121
121Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.62689019
122Tubulointerstitial nephritis (HP:0001970)1.62393371
123Gaze-evoked nystagmus (HP:0000640)1.62156498
124Malignant gastrointestinal tract tumors (HP:0006749)1.62081749
125Gastrointestinal carcinoma (HP:0002672)1.62081749
126Abnormality of the frontal sinuses (HP:0002687)1.62055810
127Hematochezia (HP:0002573)1.61808739
128Skull defect (HP:0001362)1.61680122
129Bladder carcinoma (HP:0002862)1.61462926
130Bladder neoplasm (HP:0009725)1.61462926
131Optic nerve coloboma (HP:0000588)1.61181242
132Highly arched eyebrow (HP:0002553)1.60592604
133Glioma (HP:0009733)1.59277374
134Abnormality of the astrocytes (HP:0100707)1.59274597
135Astrocytoma (HP:0009592)1.59274597
136B lymphocytopenia (HP:0010976)1.58667883
137Abnormality of B cell number (HP:0010975)1.58667883
138Abnormal hair whorl (HP:0010721)1.58480038
139Widely spaced teeth (HP:0000687)1.58245347
140Prominent nose (HP:0000448)1.58104523
141Abnormality of the carotid arteries (HP:0005344)1.56005219
142Clubbing of toes (HP:0100760)1.54958299
143Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.54913956
144Abnormality of the intervertebral disk (HP:0005108)1.54751198
145Chronic hepatic failure (HP:0100626)1.54240430
146Meckel diverticulum (HP:0002245)1.54107823
147Aplasia/Hypoplasia of the sternum (HP:0006714)1.53981541
148Cutis marmorata (HP:0000965)1.53946055
149Neoplasm of the oral cavity (HP:0100649)1.53652666
150Preaxial hand polydactyly (HP:0001177)1.53590322
151Myelodysplasia (HP:0002863)1.52674992
152Chin dimple (HP:0010751)1.52398317
153Acute lymphatic leukemia (HP:0006721)1.51864944
154Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.50587767
155IgA deficiency (HP:0002720)1.49197478
156Subacute progressive viral hepatitis (HP:0006572)1.48943888
157Recurrent viral infections (HP:0004429)1.48572657
158Tapered finger (HP:0001182)1.48359695
159Short middle phalanx of the 5th finger (HP:0004220)1.48156018
160Microtia (HP:0008551)1.47313606
161Abnormality of the ileum (HP:0001549)1.47294294
162Short philtrum (HP:0000322)1.46913830
163Prostate neoplasm (HP:0100787)1.46283715

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB32.74737833
2CDC72.48077947
3MAP3K42.48056864
4FRK2.44060794
5NUAK12.43204958
6SRPK12.37573910
7BRD42.37366996
8ZAK2.28854739
9CDK122.16641204
10MKNK11.89872536
11TRIM281.88194480
12INSRR1.87673464
13WEE11.82547471
14MKNK21.74809537
15ATR1.72992981
16LATS11.69030229
17EPHA41.66735339
18TLK11.64524398
19CAMK1G1.63511234
20WNK31.63296795
21MAP4K21.62588645
22SIK21.57571309
23MAP3K141.53359483
24STK38L1.49872860
25CAMK1D1.48183548
26MELK1.47001930
27YES11.46121608
28CDK91.42514833
29TAF11.42460518
30PASK1.40368571
31NEK21.37364860
32BMPR1B1.34941977
33STK41.32826960
34SGK21.32084804
35FGFR31.29706823
36IRAK41.27433673
37AKT31.25246276
38MAP2K71.21806036
39JAK31.21234202
40ATM1.21202145
41MAP3K101.20362237
42PLK41.19739067
43CCNB11.19066576
44CHEK21.18763816
45DYRK31.16723692
46CHUK1.15557733
47DYRK21.13004192
48MARK11.10516675
49PLK31.09816371
50HIPK21.09206724
51VRK11.08930836
52CDK31.06612003
53BMPR21.04815298
54CDK191.03280863
55FGFR21.01776878
56CDK61.01618600
57TGFBR11.01021402
58STK30.99901601
59EIF2AK20.96173291
60ACVR1B0.95949233
61RPS6KA50.95909754
62SIK30.95321828
63TXK0.91893790
64CLK10.90142919
65MAPK130.89808707
66BCR0.89694959
67PKN10.88817266
68CHEK10.88613490
69TEC0.87210089
70SGK30.86231121
71NTRK20.85596104
72AURKB0.85248754
73EPHA30.82900074
74CASK0.82064333
75WNK10.81679020
76OXSR10.80067076
77TNIK0.78284694
78DYRK1B0.77335089
79PNCK0.76665421
80PAK30.76371599
81MAP2K40.76338018
82BUB10.74397745
83PINK10.74367346
84CSNK1G10.72996646
85TYK20.72819949
86BRSK20.72478187
87CSNK1A1L0.71881972
88CDK10.70724331
89GRK10.70249622
90CDC42BPA0.70076561
91IRAK10.69726625
92ADRBK20.69405729
93KIT0.68552868
94STK390.67685977
95CSNK1G20.64759308
96PRKDC0.64665705
97SGK10.64609153
98CSF1R0.63959839
99RPS6KA40.62949755
100MAPK140.62278678
101RPS6KB10.60843399
102CSNK1E0.60758933
103CDK20.60660274
104JAK10.59850402
105TRPM70.59171209
106MAP3K130.58887026
107BRSK10.57737006
108PIM10.57289892
109PLK20.56329957
110AKT10.56272988
111MINK10.55998167
112NLK0.55953336
113FGFR10.54788919
114NTRK30.54555588
115IKBKB0.54498117
116ERBB20.54479235
117STK110.54212081
118SGK2230.53753663
119SGK4940.53753663
120CAMKK20.53729779
121ITK0.53493895
122CDK40.53288664
123PLK10.53160587
124CDK80.50942882
125MARK30.50747564
126TAOK30.50024931
127TTK0.48431716
128GSK3B0.47871143
129DYRK1A0.47565529
130EIF2AK30.47473562
131KSR10.47308008
132UHMK10.47247209
133CSNK1D0.46608783
134LMTK20.46317292
135PRKCG0.46164608
136BTK0.45920222
137NEK60.45911158
138PRKCE0.45305106
139IRAK20.43718097
140CSNK1G30.41434087
141PIK3CA0.40575501
142CAMK40.37637036

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20093506
2Non-homologous end-joining_Homo sapiens_hsa034502.17644147
3Systemic lupus erythematosus_Homo sapiens_hsa053222.07739129
4Fanconi anemia pathway_Homo sapiens_hsa034602.00999602
5Cell cycle_Homo sapiens_hsa041101.76616302
6Transcriptional misregulation in cancer_Homo sapiens_hsa052021.63878341
7Phototransduction_Homo sapiens_hsa047441.59634742
8Mismatch repair_Homo sapiens_hsa034301.58304750
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.54084945
10RNA polymerase_Homo sapiens_hsa030201.48960198
11Protein export_Homo sapiens_hsa030601.47257200
12Selenocompound metabolism_Homo sapiens_hsa004501.45798128
13Primary immunodeficiency_Homo sapiens_hsa053401.45547588
14Alcoholism_Homo sapiens_hsa050341.44077817
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43406389
16MicroRNAs in cancer_Homo sapiens_hsa052061.41578793
17Homologous recombination_Homo sapiens_hsa034401.39771902
18Propanoate metabolism_Homo sapiens_hsa006401.39406359
19DNA replication_Homo sapiens_hsa030301.34646526
20Base excision repair_Homo sapiens_hsa034101.32213570
21mRNA surveillance pathway_Homo sapiens_hsa030151.29277130
22Butanoate metabolism_Homo sapiens_hsa006501.29013669
23Herpes simplex infection_Homo sapiens_hsa051681.28554120
24Spliceosome_Homo sapiens_hsa030401.26055419
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23530908
26B cell receptor signaling pathway_Homo sapiens_hsa046621.21994135
27Viral carcinogenesis_Homo sapiens_hsa052031.21190130
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16979404
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16661247
30RNA degradation_Homo sapiens_hsa030181.14997271
31Measles_Homo sapiens_hsa051621.14355079
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12173877
33Small cell lung cancer_Homo sapiens_hsa052221.07935338
34Chronic myeloid leukemia_Homo sapiens_hsa052201.07607028
35Regulation of autophagy_Homo sapiens_hsa041401.05445061
36HTLV-I infection_Homo sapiens_hsa051661.04901894
37Colorectal cancer_Homo sapiens_hsa052101.03121215
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.01261369
39Glutamatergic synapse_Homo sapiens_hsa047241.00172272
40Prostate cancer_Homo sapiens_hsa052150.99925489
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99257698
42T cell receptor signaling pathway_Homo sapiens_hsa046600.97479929
43Basal cell carcinoma_Homo sapiens_hsa052170.96513467
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96030256
45Lysine degradation_Homo sapiens_hsa003100.95928466
46Antigen processing and presentation_Homo sapiens_hsa046120.95695528
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.95676031
48Dorso-ventral axis formation_Homo sapiens_hsa043200.95451806
49Hepatitis B_Homo sapiens_hsa051610.94957731
50Osteoclast differentiation_Homo sapiens_hsa043800.93548412
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93419899
52p53 signaling pathway_Homo sapiens_hsa041150.93062307
53Leishmaniasis_Homo sapiens_hsa051400.92516187
54Influenza A_Homo sapiens_hsa051640.92277302
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91725410
56Ether lipid metabolism_Homo sapiens_hsa005650.90378125
57Olfactory transduction_Homo sapiens_hsa047400.89719492
58Wnt signaling pathway_Homo sapiens_hsa043100.89684442
59Adherens junction_Homo sapiens_hsa045200.88582036
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87996468
61Pancreatic cancer_Homo sapiens_hsa052120.87939033
62Nucleotide excision repair_Homo sapiens_hsa034200.87708768
63Viral myocarditis_Homo sapiens_hsa054160.86187793
64Dopaminergic synapse_Homo sapiens_hsa047280.86183289
65Allograft rejection_Homo sapiens_hsa053300.85908459
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85410050
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85315409
68TGF-beta signaling pathway_Homo sapiens_hsa043500.84650007
69TNF signaling pathway_Homo sapiens_hsa046680.84331001
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83904751
71FoxO signaling pathway_Homo sapiens_hsa040680.83125313
72Hematopoietic cell lineage_Homo sapiens_hsa046400.82222194
73Notch signaling pathway_Homo sapiens_hsa043300.80200359
74Endometrial cancer_Homo sapiens_hsa052130.80047466
75Linoleic acid metabolism_Homo sapiens_hsa005910.79377810
76Chemokine signaling pathway_Homo sapiens_hsa040620.78811110
77Pathways in cancer_Homo sapiens_hsa052000.78703046
78Type II diabetes mellitus_Homo sapiens_hsa049300.78638295
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77956882
80Steroid biosynthesis_Homo sapiens_hsa001000.77828295
81Epstein-Barr virus infection_Homo sapiens_hsa051690.77125017
82Toxoplasmosis_Homo sapiens_hsa051450.77010451
83Autoimmune thyroid disease_Homo sapiens_hsa053200.76654253
84RNA transport_Homo sapiens_hsa030130.74113228
85Non-small cell lung cancer_Homo sapiens_hsa052230.73829162
86Axon guidance_Homo sapiens_hsa043600.73682819
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73397014
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73389789
89Prolactin signaling pathway_Homo sapiens_hsa049170.72339597
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71383200
91Serotonergic synapse_Homo sapiens_hsa047260.71344680
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.71299511
93Basal transcription factors_Homo sapiens_hsa030220.70210923
94Cocaine addiction_Homo sapiens_hsa050300.70134605
95Circadian entrainment_Homo sapiens_hsa047130.70028815
96Long-term depression_Homo sapiens_hsa047300.69608784
97Hedgehog signaling pathway_Homo sapiens_hsa043400.69027404
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69023248
99Graft-versus-host disease_Homo sapiens_hsa053320.68264481
100Proteoglycans in cancer_Homo sapiens_hsa052050.68225004
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68006718
102Circadian rhythm_Homo sapiens_hsa047100.67661438
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67268087
104Hippo signaling pathway_Homo sapiens_hsa043900.66913988
105Cholinergic synapse_Homo sapiens_hsa047250.66890308
106Purine metabolism_Homo sapiens_hsa002300.66473291
107MAPK signaling pathway_Homo sapiens_hsa040100.65795937
108Nitrogen metabolism_Homo sapiens_hsa009100.65200754
109GABAergic synapse_Homo sapiens_hsa047270.64473486
110Apoptosis_Homo sapiens_hsa042100.63814435
111Type I diabetes mellitus_Homo sapiens_hsa049400.63529411
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63269630
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.62155620
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61811882
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61716270
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61670858
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.61457839
118ErbB signaling pathway_Homo sapiens_hsa040120.61088096
119Melanoma_Homo sapiens_hsa052180.60983653
120Amphetamine addiction_Homo sapiens_hsa050310.60632385
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58907443
122Acute myeloid leukemia_Homo sapiens_hsa052210.58757330
123Morphine addiction_Homo sapiens_hsa050320.58382851
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58031348
125cAMP signaling pathway_Homo sapiens_hsa040240.57810633
126mTOR signaling pathway_Homo sapiens_hsa041500.57451141
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57207691
128Glioma_Homo sapiens_hsa052140.56938859
129Nicotine addiction_Homo sapiens_hsa050330.56293333
130Insulin secretion_Homo sapiens_hsa049110.55971703
131Hepatitis C_Homo sapiens_hsa051600.55960744
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55757736
133Inositol phosphate metabolism_Homo sapiens_hsa005620.55666424
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55382905
135Platelet activation_Homo sapiens_hsa046110.54767358
136Taste transduction_Homo sapiens_hsa047420.54745361
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54513315
138Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53755748
139Oocyte meiosis_Homo sapiens_hsa041140.53185644
140Pyrimidine metabolism_Homo sapiens_hsa002400.52412050
141One carbon pool by folate_Homo sapiens_hsa006700.47945883
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45032892
143Huntingtons disease_Homo sapiens_hsa050160.44178981
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38524477
145Choline metabolism in cancer_Homo sapiens_hsa052310.36908618
146Glycerolipid metabolism_Homo sapiens_hsa005610.34636661
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31435225
148Peroxisome_Homo sapiens_hsa041460.31063383
149Melanogenesis_Homo sapiens_hsa049160.30251226
150Tryptophan metabolism_Homo sapiens_hsa003800.28817491

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