PHKA1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome assembly (GO:0001675)6.47162049
2sulfate transmembrane transport (GO:1902358)6.31216743
3mRNA modification (GO:0016556)6.06340131
4regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)5.90914937
5sterol catabolic process (GO:0016127)5.69009868
6cholesterol catabolic process (GO:0006707)5.69009868
7melanocyte differentiation (GO:0030318)5.54930655
8regulation of cholesterol homeostasis (GO:2000188)5.52405654
9sulfate transport (GO:0008272)5.31046361
10DNA replication-dependent nucleosome assembly (GO:0006335)5.19020175
11DNA replication-dependent nucleosome organization (GO:0034723)5.19020175
12COPII vesicle coating (GO:0048208)5.14134935
13virion assembly (GO:0019068)4.98421457
14pigment cell differentiation (GO:0050931)4.90105417
15negative regulation of cell aging (GO:0090344)4.89056907
16entrainment of circadian clock by photoperiod (GO:0043153)4.86249877
17base-excision repair (GO:0006284)4.76978041
18TOR signaling (GO:0031929)4.74613624
19entrainment of circadian clock (GO:0009649)4.71892401
20negative regulation of keratinocyte proliferation (GO:0010839)4.64956822
21mitotic sister chromatid cohesion (GO:0007064)4.53489177
22negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.46517062
23cerebral cortex radially oriented cell migration (GO:0021799)4.44592726
24viral protein processing (GO:0019082)4.39809831
25positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc4.35669126
26tRNA methylation (GO:0030488)4.31485109
27positive regulation of astrocyte differentiation (GO:0048711)4.24441270
28lipoprotein transport (GO:0042953)4.20757347
29embryonic digestive tract morphogenesis (GO:0048557)4.18864260
30mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.15053688
31base-excision repair, AP site formation (GO:0006285)4.12410145
32cytidine metabolic process (GO:0046087)4.12099702
33cytidine catabolic process (GO:0006216)4.12099702
34cytidine deamination (GO:0009972)4.12099702
35positive regulation of extracellular matrix organization (GO:1903055)4.08835338
36regulation of megakaryocyte differentiation (GO:0045652)4.05118884
37positive regulation of stem cell differentiation (GO:2000738)4.02345731
38mitochondrial calcium ion homeostasis (GO:0051560)4.00627044
39meiotic chromosome segregation (GO:0045132)4.00130293
40positive regulation of mitochondrial membrane permeability (GO:0035794)3.99280201
41mitochondrial DNA replication (GO:0006264)3.97567621
42regulation of synapse maturation (GO:0090128)3.85203346
43photoperiodism (GO:0009648)3.83599978
44mitochondrial genome maintenance (GO:0000002)3.81987695
45translesion synthesis (GO:0019985)3.78859215
46mesenchymal cell differentiation involved in renal system development (GO:2001012)3.77902651
47mesenchymal cell differentiation involved in kidney development (GO:0072161)3.77902651
48mucosal-associated lymphoid tissue development (GO:0048537)3.77726729
49Peyers patch development (GO:0048541)3.77726729
50DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.75421138
51positive regulation of neuroblast proliferation (GO:0002052)3.75352234
52GDP-mannose metabolic process (GO:0019673)3.74548648
53seminiferous tubule development (GO:0072520)3.70386155
54negative regulation of stress fiber assembly (GO:0051497)3.65332592
55neuroepithelial cell differentiation (GO:0060563)3.65148146
56regulation of metalloenzyme activity (GO:0048552)3.64287364
57establishment of protein localization to Golgi (GO:0072600)3.62685889
58regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.60766636
59protein targeting to Golgi (GO:0000042)3.59126696
60regulation of gene silencing (GO:0060968)3.59049439
61pyrimidine ribonucleoside catabolic process (GO:0046133)3.58377914
62response to gravity (GO:0009629)3.57971834
63regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.52777473
64regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.49909959
65mammary gland epithelial cell proliferation (GO:0033598)3.48396601
66cell proliferation in forebrain (GO:0021846)3.43061460
67histone deubiquitination (GO:0016578)3.40032377
68mammary gland epithelial cell differentiation (GO:0060644)3.37042594
69mRNA splice site selection (GO:0006376)3.36117705
70positive regulation of erythrocyte differentiation (GO:0045648)3.34285967
71detection of light stimulus involved in visual perception (GO:0050908)3.33311368
72detection of light stimulus involved in sensory perception (GO:0050962)3.33311368
73DNA damage response, signal transduction resulting in transcription (GO:0042772)3.31010506
74retrograde transport, vesicle recycling within Golgi (GO:0000301)3.25003439
75positive regulation of histone deacetylation (GO:0031065)3.24640167
76positive regulation of DNA-dependent DNA replication (GO:2000105)3.23424088
77protein polyglutamylation (GO:0018095)3.21630060
78regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.20381457
79peptidyl-lysine dimethylation (GO:0018027)3.19473314
80regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.18012863
81somatic hypermutation of immunoglobulin genes (GO:0016446)3.15866091
82somatic diversification of immune receptors via somatic mutation (GO:0002566)3.15866091
83regulation of receptor biosynthetic process (GO:0010869)3.15278088
84cellular response to ATP (GO:0071318)3.14584635
85regulation of hormone biosynthetic process (GO:0046885)3.12797360
86protein K6-linked ubiquitination (GO:0085020)3.11981041
87regulation of centriole replication (GO:0046599)3.10544502
88negative regulation of oligodendrocyte differentiation (GO:0048715)3.08449737
89negative regulation of gene silencing (GO:0060969)3.07092644
90response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.06617129
91negative regulation of actin filament bundle assembly (GO:0032232)3.03260819
92RNA localization (GO:0006403)3.00776831
93positive regulation of protein homooligomerization (GO:0032464)2.99932925
94fibroblast migration (GO:0010761)2.99560645
95ER to Golgi vesicle-mediated transport (GO:0006888)2.97522685
96stem cell differentiation (GO:0048863)2.97382909
97mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.97335176
98positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.97335176
99myoblast migration (GO:0051451)2.93542889
100hematopoietic stem cell differentiation (GO:0060218)12.7938621

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.42614306
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse8.32341862
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.94034876
4E2F7_22180533_ChIP-Seq_HELA_Human4.89604311
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.38316444
6ESR1_20079471_ChIP-ChIP_T-47D_Human3.90756060
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.88867841
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.88867841
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.88867841
10ESR1_15608294_ChIP-ChIP_MCF-7_Human3.50803000
11EGR1_23403033_ChIP-Seq_LIVER_Mouse3.41353203
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.38072006
13DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.20800675
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.60292892
15ELK4_26923725_Chip-Seq_MESODERM_Mouse2.33420721
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.04822949
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.04567812
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.02967836
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.89666268
20CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.87714408
21HIF1A_21447827_ChIP-Seq_MCF-7_Human1.77305366
22STAT3_1855785_ChIP-Seq_MESCs_Mouse1.77159843
23MYC_22102868_ChIP-Seq_BL_Human1.74356166
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.70567839
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54581438
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39401405
27YY1_21170310_ChIP-Seq_MESCs_Mouse1.37985718
28SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37340026
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31693659
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27117981
31IRF1_19129219_ChIP-ChIP_H3396_Human1.26190085
32BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25743926
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23235427
34SCL_19346495_ChIP-Seq_HPC-7_Human1.20814923
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15046423
36XRN2_22483619_ChIP-Seq_HELA_Human1.14231731
37RUNX1_27514584_Chip-Seq_MCF-7_Human1.09930201
38RARB_24833708_ChIP-Seq_LIVER_Mouse1.09662305
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08549946
40TTF2_22483619_ChIP-Seq_HELA_Human1.06940359
41CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06534908
42GABP_19822575_ChIP-Seq_HepG2_Human1.06347060
43VDR_21846776_ChIP-Seq_THP-1_Human1.03994254
44AR_21909140_ChIP-Seq_LNCAP_Human1.03401781
45VDR_23849224_ChIP-Seq_CD4+_Human1.03304952
46BRD4_25478319_ChIP-Seq_HGPS_Human0.99731504
47NOTCH1_21737748_ChIP-Seq_TLL_Human0.98638770
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98145218
49ATF3_27146783_Chip-Seq_COLON_Human0.97559695
50CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95720661
51FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95030261
52PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93405236
53GATA3_24758297_ChIP-Seq_MCF-7_Human0.92808227
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91200496
55DCP1A_22483619_ChIP-Seq_HELA_Human0.91074047
56TCF7_22412390_ChIP-Seq_EML_Mouse0.90825223
57NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.90238426
58E2F4_17652178_ChIP-ChIP_JURKAT_Human0.89981862
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89040795
60ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89036619
61CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88148245
62BCL6_27268052_Chip-Seq_Bcells_Human0.86676278
63CIITA_25753668_ChIP-Seq_RAJI_Human0.84100362
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83791209
65RACK7_27058665_Chip-Seq_MCF-7_Human0.82465116
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82427833
67ZFX_18555785_ChIP-Seq_MESCs_Mouse0.82113090
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.81013808
69E2F1_20622854_ChIP-Seq_HELA_Human0.79492550
70ERG_20517297_ChIP-Seq_VCAP_Human0.78304027
71RARA_24833708_ChIP-Seq_LIVER_Mouse0.76437901
72STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.76381667
73PADI4_21655091_ChIP-ChIP_MCF-7_Human0.75734368
74WT1_19549856_ChIP-ChIP_CCG9911_Human0.75490420
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.73399738
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73168938
77RXRA_24833708_ChIP-Seq_LIVER_Mouse0.72106382
78SMC4_20622854_ChIP-Seq_HELA_Human0.71458017
79FOXP1_21924763_ChIP-Seq_HESCs_Human0.71329527
80PHF8_20622854_ChIP-Seq_HELA_Human0.70512866
81NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.69909986
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.69189541
83AHR_22903824_ChIP-Seq_MCF-7_Human0.69102184
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.68802294
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.68564572
86ZNF274_21170338_ChIP-Seq_K562_Hela0.65612351
87FUS_26573619_Chip-Seq_HEK293_Human0.64904240
88SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.64378806
89SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.64378806
90AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.63702485
91KDM2B_26808549_Chip-Seq_DND41_Human0.62631920
92DROSHA_22980978_ChIP-Seq_HELA_Human0.62396858
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.60916554
94HOXB7_26014856_ChIP-Seq_BT474_Human0.60852520
95FOXA2_19822575_ChIP-Seq_HepG2_Human0.60232416
96SOX2_27498859_Chip-Seq_STOMACH_Mouse0.58174854
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.58099323
98GATA2_22383799_ChIP-Seq_G1ME_Mouse0.57666024
99HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.56991545
100GATA6_25053715_ChIP-Seq_YYC3_Human0.56768598

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH9.30496702
2MP0000003_abnormal_adipose_tissue6.58013296
3MP0005076_abnormal_cell_differentiation3.13091447
4MP0001502_abnormal_circadian_rhythm3.03860822
5MP0005375_adipose_tissue_phenotype2.77241626
6MP0004233_abnormal_muscle_weight2.51733779
7MP0002933_joint_inflammation2.43978967
8MP0008961_abnormal_basal_metabolism2.22575140
9MP0009278_abnormal_bone_marrow2.22100249
10MP0000371_diluted_coat_color2.09906164
11MP0009250_abnormal_appendicular_skeleto2.09347838
12MP0000013_abnormal_adipose_tissue10.2363955
13MP0001986_abnormal_taste_sensitivity1.83193661
14MP0008260_abnormal_autophagy1.82483306
15MP0010030_abnormal_orbit_morphology1.70036508
16MP0003077_abnormal_cell_cycle1.66129585
17MP0006054_spinal_hemorrhage1.61539562
18MP0001984_abnormal_olfaction1.51640858
19MP0010307_abnormal_tumor_latency1.49233831
20MP0002896_abnormal_bone_mineralization1.32366978
21MP0003221_abnormal_cardiomyocyte_apopto1.32146933
22MP0009115_abnormal_fat_cell1.30656482
23MP0002736_abnormal_nociception_after1.30495581
24MP0000470_abnormal_stomach_morphology1.26518445
25MP0003195_calcinosis1.26438050
26MP0004484_altered_response_of1.23464038
27MP0004808_abnormal_hematopoietic_stem1.19217693
28MP0010094_abnormal_chromosome_stability1.16165174
29MP0002075_abnormal_coat/hair_pigmentati1.15789123
30MP0000566_synostosis1.12619046
31MP0005551_abnormal_eye_electrophysiolog1.11924368
32MP0000627_abnormal_mammary_gland1.07852508
33MP0004145_abnormal_muscle_electrophysio1.05980673
34MP0005334_abnormal_fat_pad1.02514767
35MP0003959_abnormal_lean_body1.00175061
36MP0001186_pigmentation_phenotype0.97805079
37MP0000750_abnormal_muscle_regeneration0.96961458
38MP0000538_abnormal_urinary_bladder0.96565416
39MP0010368_abnormal_lymphatic_system0.94708004
40MP0001968_abnormal_touch/_nociception0.93124669
41MP0000767_abnormal_smooth_muscle0.91365949
42MP0003948_abnormal_gas_homeostasis0.90129485
43MP0003111_abnormal_nucleus_morphology0.85692617
44MP0003191_abnormal_cellular_cholesterol0.85513130
45MP0004087_abnormal_muscle_fiber0.82473788
46MP0002210_abnormal_sex_determination0.77678879
47MP0004742_abnormal_vestibular_system0.76393783
48MP0001672_abnormal_embryogenesis/_devel0.71167123
49MP0005380_embryogenesis_phenotype0.71167123
50MP0003984_embryonic_growth_retardation0.70363223
51MP0001666_abnormal_nutrient_absorption0.68690626
52MP0000749_muscle_degeneration0.67047875
53MP0002088_abnormal_embryonic_growth/wei0.66804623
54MP0005452_abnormal_adipose_tissue0.66710983
55MP0009931_abnormal_skin_appearance0.65244600
56MP0003943_abnormal_hepatobiliary_system0.62690188
57MP0001661_extended_life_span0.62242553
58MP0008058_abnormal_DNA_repair0.61410339
59MP0001485_abnormal_pinna_reflex0.60774219
60MP0004019_abnormal_vitamin_homeostasis0.60383215
61MP0004885_abnormal_endolymph0.58572555
62MP0003693_abnormal_embryo_hatching0.58270056
63MP0003786_premature_aging0.57695480
64MP0002019_abnormal_tumor_incidence0.55331946
65MP0008057_abnormal_DNA_replication0.54372622
66MP0004036_abnormal_muscle_relaxation0.54303705
67MP0002168_other_aberrant_phenotype0.53750234
68MP0005174_abnormal_tail_pigmentation0.53047152
69MP0002118_abnormal_lipid_homeostasis0.52740192
70MP0002970_abnormal_white_adipose0.52187789
71MP0004264_abnormal_extraembryonic_tissu0.51747257
72MP0000427_abnormal_hair_cycle0.49765338
73MP0003787_abnormal_imprinting0.49318766
74MP0000759_abnormal_skeletal_muscle0.48271487
75MP0001944_abnormal_pancreas_morphology0.48199385
76MP0001664_abnormal_digestion0.48140182
77MP0010329_abnormal_lipoprotein_level0.48021454
78MP0002282_abnormal_trachea_morphology0.47923160
79MP0002106_abnormal_muscle_physiology0.47611579
80MP0005646_abnormal_pituitary_gland0.47385195
81MP0003045_fibrosis0.46700422
82MP0002081_perinatal_lethality0.46374050
83MP0001145_abnormal_male_reproductive0.46245789
84MP0000747_muscle_weakness0.46210644
85MP0002114_abnormal_axial_skeleton0.45811097
86MP0008770_decreased_survivor_rate0.45803820
87MP0005409_darkened_coat_color0.45386176
88MP0008438_abnormal_cutaneous_collagen0.45374432
89MP0001943_abnormal_respiration0.45217654
90MP0001929_abnormal_gametogenesis0.44818988
91MP0002135_abnormal_kidney_morphology0.43975955
92MP0000762_abnormal_tongue_morphology0.43424566
93MP0002928_abnormal_bile_duct0.43264080
94MP0001879_abnormal_lymphatic_vessel0.42496642
95MP0010770_preweaning_lethality0.42234176
96MP0002082_postnatal_lethality0.42234176
97MP0004197_abnormal_fetal_growth/weight/0.41888838
98MP0010768_mortality/aging0.41885801
99MP0003755_abnormal_palate_morphology0.41439501
100MP0002332_abnormal_exercise_endurance0.41104067

Predicted human phenotypes

RankGene SetZ-score
1Generalized hypopigmentation of hair (HP:0011358)5.78763395
2Hypoplasia of the fovea (HP:0007750)5.17165533
3Aplasia/Hypoplasia of the fovea (HP:0008060)5.17165533
4Anterior segment dysgenesis (HP:0007700)4.75480741
5Prominent supraorbital ridges (HP:0000336)4.70844386
6Renal cortical cysts (HP:0000803)4.46233785
7Abnormality of the renal cortex (HP:0011035)4.43691606
8Exercise-induced myalgia (HP:0003738)4.35041754
9Vertebral arch anomaly (HP:0008438)4.34347297
10Proximal amyotrophy (HP:0007126)4.32849345
11Villous atrophy (HP:0011473)4.30647646
12Abnormality of small intestinal villus morphology (HP:0011472)4.30647646
13Abnormality of the fovea (HP:0000493)4.20576947
14Thrombocytosis (HP:0001894)4.11060631
15Wormian bones (HP:0002645)4.05451771
16Curly hair (HP:0002212)3.87787482
17Cholecystitis (HP:0001082)3.84092593
18Abnormal gallbladder physiology (HP:0012438)3.84092593
19Rib fusion (HP:0000902)3.75786069
20Small epiphyses (HP:0010585)3.75178384
21Progressive external ophthalmoplegia (HP:0000590)3.59124228
22Delayed epiphyseal ossification (HP:0002663)3.53435930
23Abnormality of methionine metabolism (HP:0010901)3.50507891
24Flat capital femoral epiphysis (HP:0003370)3.37167542
25Generalized hypopigmentation (HP:0007513)3.32817410
26Abnormal hair laboratory examination (HP:0003328)3.32510769
27Ocular albinism (HP:0001107)3.28134895
28Abnormal albumin level (HP:0012116)3.26259976
29Hypoalbuminemia (HP:0003073)3.26259976
30Prominent forehead (HP:0011220)3.22498572
31Tracheomalacia (HP:0002779)3.16971927
32Aplasia/Hypoplasia of the macula (HP:0008059)3.12860978
33Abnormality of sulfur amino acid metabolism (HP:0004339)2.95782143
34Hypoplasia of the capital femoral epiphysis (HP:0003090)2.94902405
35Aortic regurgitation (HP:0001659)2.88372561
36Woolly hair (HP:0002224)2.85035165
37Aplasia/Hypoplasia affecting the retina (HP:0008061)2.82742886
38Abnormality of the labia majora (HP:0012881)2.79389341
39Hypoplastic labia majora (HP:0000059)2.77196287
40Iris hypopigmentation (HP:0007730)2.70867722
41Abnormality of the proximal phalanges of the hand (HP:0009834)2.66533434
42Overlapping toe (HP:0001845)2.63419091
43Increased mean platelet volume (HP:0011877)2.60932278
44Volvulus (HP:0002580)2.60848299
45Polyuria (HP:0000103)2.56720808
46Broad distal phalanx of finger (HP:0009836)2.56012673
47Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.55300194
48Metaphyseal irregularity (HP:0003025)2.53923540
49Proximal placement of thumb (HP:0009623)2.51841277
50Narrow mouth (HP:0000160)2.49702774
51Carpal bone hypoplasia (HP:0001498)2.48563316
52Broad nasal tip (HP:0000455)2.48256035
53Abnormality of aspartate family amino acid metabolism (HP:0010899)2.43376093
54Flattened epiphyses (HP:0003071)2.41959066
55Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.40591156
56Absent epiphyses (HP:0010577)2.40591156
57Absent speech (HP:0001344)2.37140376
58Abnormal platelet volume (HP:0011876)2.32140022
59Rhabdomyolysis (HP:0003201)2.31069784
60Bifid uvula (HP:0000193)2.28609161
61Tetraplegia (HP:0002445)2.27933482
62Deviation of the thumb (HP:0009603)2.27870875
63Low anterior hairline (HP:0000294)2.22736991
64Capillary hemangiomas (HP:0005306)2.21735472
65Interstitial pulmonary disease (HP:0006530)2.17042854
66Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.16096821
67Abnormal drinking behavior (HP:0030082)2.14915661
68Polydipsia (HP:0001959)2.14915661
69Dislocated radial head (HP:0003083)2.14787037
70Progressive muscle weakness (HP:0003323)2.14703490
71Heterotopia (HP:0002282)2.13998161
72Midface retrusion (HP:0011800)2.10112095
73Nausea (HP:0002018)2.09983864
74Chorioretinal coloboma (HP:0000567)2.09740583
75Brittle hair (HP:0002299)2.06903228
76Abnormality of chloride homeostasis (HP:0011422)2.06884599
77Facial hemangioma (HP:0000329)2.05860575
78Pseudobulbar signs (HP:0002200)2.05684350
79Myoglobinuria (HP:0002913)2.03604399
80Irregular epiphyses (HP:0010582)2.02819073
81Ependymoma (HP:0002888)2.01547978
82Abnormal urine output (HP:0012590)2.00550113
83Abnormality of the renal medulla (HP:0100957)2.00451884
84Easy fatigability (HP:0003388)1.99658139
85Glossoptosis (HP:0000162)1.99041966
86Facial asymmetry (HP:0000324)1.98942426
87Abnormality of the anterior chamber (HP:0000593)1.97639036
88Hyperaldosteronism (HP:0000859)1.96989609
89Conjugated hyperbilirubinemia (HP:0002908)1.96643850
90Patent foramen ovale (HP:0001655)1.95356791
91Stomach cancer (HP:0012126)1.94047410
92Abnormality of the radial head (HP:0003995)1.93640287
93Nasal speech (HP:0001611)1.88213510
94Nonimmune hydrops fetalis (HP:0001790)1.87818155
95Esotropia (HP:0000565)1.86067774
96Vacuolated lymphocytes (HP:0001922)1.85955011
97Intellectual disability, moderate (HP:0002342)1.85198199
98Scrotal hypoplasia (HP:0000046)1.84428735
99Congenital stationary night blindness (HP:0007642)1.84225073
100Low posterior hairline (HP:0002162)1.84134711

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.28219379
2ZAK6.94678335
3CASK6.77287512
4CDK124.18129603
5PHKG12.70959659
6PHKG22.70959659
7MST42.64089316
8BCKDK2.55587465
9TRIM282.20004429
10TSSK62.11709609
11WNK42.10051964
12FLT31.98052918
13VRK11.95159893
14KDR1.79592256
15CCNB11.59479441
16STK38L1.48775481
17PIM11.22784717
18STK241.18923311
19EPHA21.13980904
20MET1.13716266
21MELK1.10715684
22BMX1.07447283
23RPS6KA51.05864063
24WEE11.02154552
25AKT20.98673982
26ICK0.93290987
27OBSCN0.90982194
28DAPK20.90357306
29STK390.82920199
30CHEK20.79683862
31SIK30.77936772
32BMPR1B0.75396251
33MAP3K50.75365862
34CDK60.75185498
35JAK30.73279924
36NTRK10.72042649
37PKN10.70804826
38STK100.68459485
39PRKCI0.66954410
40PRKAA10.64951648
41PNCK0.64520045
42MAPK150.62051001
43CDK70.61295059
44STK40.59421196
45WNK10.57804674
46MAPK140.56926479
47EPHA30.56358499
48AURKB0.55519232
49PRKCQ0.53123517
50LATS20.45181480
51MKNK20.44662723
52CDK80.44152482
53CAMK1G0.43631533
54ROCK10.42544583
55PDK20.40027579
56CDK40.39647508
57MTOR0.38694953
58PBK0.38370284
59NEK60.37680786
60ERBB40.37351980
61TAOK30.36285164
62MAPK100.36090909
63PTK20.35933942
64MKNK10.35920163
65LRRK20.34117557
66MAPK90.33962460
67CDK20.32531550
68MST1R0.32133211
69MAP3K80.31860778
70JAK20.27680616
71GSK3B0.27003119
72MAP3K140.26798735
73DAPK30.25991960
74CDK10.25525418
75JAK10.24967033
76AURKA0.24594859
77MAP3K10.24323742
78PRKAA20.23371915
79PIK3CA0.19239304
80CDK90.18339969
81STK30.17435295
82TRPM70.17380217
83PDGFRA0.16557659
84CHUK0.15129316
85PDPK10.14922108
86PLK10.14157598
87CDC70.13260010
88MATK0.11650698
89CSNK1E0.11122788
90ZAP700.11004830
91TNK20.10616050
92CHEK10.10475751
93HIPK20.09859134
94ATR0.09341556
95MUSK0.09228761
96ATM0.08800013
97CSNK1A1L0.06809607
98MAP3K120.06214692
99LMTK20.05654324
100RPS6KB10.05390069

Predicted pathways (KEGG)

RankGene SetZ-score
1Base excision repair_Homo sapiens_hsa034107.23808921
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.91731057
3Fructose and mannose metabolism_Homo sapiens_hsa000513.39209607
4Systemic lupus erythematosus_Homo sapiens_hsa053223.15086881
5Selenocompound metabolism_Homo sapiens_hsa004503.10328463
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86095512
7Alcoholism_Homo sapiens_hsa050342.65776151
8Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.54511783
9Circadian rhythm_Homo sapiens_hsa047102.08164117
10Fanconi anemia pathway_Homo sapiens_hsa034601.99418123
11DNA replication_Homo sapiens_hsa030301.77513560
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.70705507
13Lysine degradation_Homo sapiens_hsa003101.58808017
14RNA transport_Homo sapiens_hsa030131.58685130
15Transcriptional misregulation in cancer_Homo sapiens_hsa052021.51616188
16RNA degradation_Homo sapiens_hsa030181.40651625
17Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.40632500
18Inositol phosphate metabolism_Homo sapiens_hsa005621.40430820
19Thyroid cancer_Homo sapiens_hsa052161.35895390
20RNA polymerase_Homo sapiens_hsa030201.30953496
21Mismatch repair_Homo sapiens_hsa034301.29671631
22Mineral absorption_Homo sapiens_hsa049781.24754461
23TGF-beta signaling pathway_Homo sapiens_hsa043501.19820378
24Glucagon signaling pathway_Homo sapiens_hsa049221.17607811
25Spliceosome_Homo sapiens_hsa030401.17539367
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16769158
27Caffeine metabolism_Homo sapiens_hsa002321.14846641
28Viral carcinogenesis_Homo sapiens_hsa052031.14572571
29Dorso-ventral axis formation_Homo sapiens_hsa043201.12944062
30Adipocytokine signaling pathway_Homo sapiens_hsa049201.07588855
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06015387
32Phenylalanine metabolism_Homo sapiens_hsa003601.00992818
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99992544
34Pyrimidine metabolism_Homo sapiens_hsa002400.99288911
35Cell cycle_Homo sapiens_hsa041100.98721822
36Arginine biosynthesis_Homo sapiens_hsa002200.97840202
37Small cell lung cancer_Homo sapiens_hsa052220.95129902
38Biosynthesis of amino acids_Homo sapiens_hsa012300.95093305
39Arginine and proline metabolism_Homo sapiens_hsa003300.92444567
40Insulin resistance_Homo sapiens_hsa049310.88233120
41Calcium signaling pathway_Homo sapiens_hsa040200.86735768
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84245071
43Hippo signaling pathway_Homo sapiens_hsa043900.83386042
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80182044
45Hedgehog signaling pathway_Homo sapiens_hsa043400.79413548
46FoxO signaling pathway_Homo sapiens_hsa040680.77392408
47Sphingolipid metabolism_Homo sapiens_hsa006000.75481874
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74507120
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71173708
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70453336
51Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68720127
52Estrogen signaling pathway_Homo sapiens_hsa049150.68445929
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.64468315
54Galactose metabolism_Homo sapiens_hsa000520.61743138
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58910625
56Thyroid hormone synthesis_Homo sapiens_hsa049180.56974620
57African trypanosomiasis_Homo sapiens_hsa051430.56523797
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54314532
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53655513
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52707957
61Phototransduction_Homo sapiens_hsa047440.52655671
62Basal cell carcinoma_Homo sapiens_hsa052170.52637016
63Regulation of autophagy_Homo sapiens_hsa041400.51235015
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49883300
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49563336
66Butanoate metabolism_Homo sapiens_hsa006500.48547659
67AMPK signaling pathway_Homo sapiens_hsa041520.46459100
68Gastric acid secretion_Homo sapiens_hsa049710.45216015
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44375172
70Tyrosine metabolism_Homo sapiens_hsa003500.43149066
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42715350
72Purine metabolism_Homo sapiens_hsa002300.41824358
73MicroRNAs in cancer_Homo sapiens_hsa052060.41822299
74Steroid biosynthesis_Homo sapiens_hsa001000.41389133
75Prostate cancer_Homo sapiens_hsa052150.40432742
76Homologous recombination_Homo sapiens_hsa034400.39799838
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37419703
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35265658
79Salivary secretion_Homo sapiens_hsa049700.35077303
80Dilated cardiomyopathy_Homo sapiens_hsa054140.34962459
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34907067
82Ovarian steroidogenesis_Homo sapiens_hsa049130.34558736
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34177589
84Insulin signaling pathway_Homo sapiens_hsa049100.34079062
85Sulfur relay system_Homo sapiens_hsa041220.33700948
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33521839
87TNF signaling pathway_Homo sapiens_hsa046680.31715551
88ABC transporters_Homo sapiens_hsa020100.31445368
89Nucleotide excision repair_Homo sapiens_hsa034200.29928623
90Melanogenesis_Homo sapiens_hsa049160.29422158
91Bile secretion_Homo sapiens_hsa049760.29013291
92Amphetamine addiction_Homo sapiens_hsa050310.27208016
93Tight junction_Homo sapiens_hsa045300.26379122
94HIF-1 signaling pathway_Homo sapiens_hsa040660.25826801
95p53 signaling pathway_Homo sapiens_hsa041150.25711812
96mRNA surveillance pathway_Homo sapiens_hsa030150.25600371
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25442975
98Insulin secretion_Homo sapiens_hsa049110.24849829
99Non-small cell lung cancer_Homo sapiens_hsa052230.24434031
100Taste transduction_Homo sapiens_hsa047420.22414262

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