PHLDA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.69964277
2chondrocyte proliferation (GO:0035988)4.67815089
3substrate-dependent cell migration (GO:0006929)4.59523775
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.46672938
5L-phenylalanine catabolic process (GO:0006559)4.46672938
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.39834808
7L-phenylalanine metabolic process (GO:0006558)4.39834808
8negative regulation of fibrinolysis (GO:0051918)4.28658966
9ganglion development (GO:0061548)4.20566381
10protein carboxylation (GO:0018214)4.09880768
11peptidyl-glutamic acid carboxylation (GO:0017187)4.09880768
12negative regulation of chondrocyte differentiation (GO:0032331)4.07001466
13regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.95180874
14protein localization to endosome (GO:0036010)3.82991471
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.80650184
16aromatic amino acid family catabolic process (GO:0009074)3.80029538
17retina vasculature morphogenesis in camera-type eye (GO:0061299)3.78508007
18regulation of fibrinolysis (GO:0051917)3.78256381
19alpha-linolenic acid metabolic process (GO:0036109)3.72485930
20bile acid biosynthetic process (GO:0006699)3.65505945
21regulation of cholesterol homeostasis (GO:2000188)3.58892149
22fibrinolysis (GO:0042730)3.58370271
23negative regulation of axon extension involved in axon guidance (GO:0048843)3.51159063
24cysteine metabolic process (GO:0006534)3.49720502
25kynurenine metabolic process (GO:0070189)3.41198847
26fibroblast migration (GO:0010761)3.40918881
27plasma lipoprotein particle clearance (GO:0034381)3.40077430
28negative regulation of keratinocyte proliferation (GO:0010839)3.39768365
29COPI coating of Golgi vesicle (GO:0048205)3.38260594
30Golgi transport vesicle coating (GO:0048200)3.38260594
31cellular glucuronidation (GO:0052695)3.37140118
32endodermal cell differentiation (GO:0035987)3.31566099
33muscle cell migration (GO:0014812)3.29353290
34tryptophan catabolic process (GO:0006569)3.28131274
35indole-containing compound catabolic process (GO:0042436)3.28131274
36indolalkylamine catabolic process (GO:0046218)3.28131274
37response to nitrosative stress (GO:0051409)3.27994652
38neuron projection extension involved in neuron projection guidance (GO:1902284)3.27409537
39axon extension involved in axon guidance (GO:0048846)3.27409537
40cell migration involved in sprouting angiogenesis (GO:0002042)3.25843464
41urea cycle (GO:0000050)3.25623796
42urea metabolic process (GO:0019627)3.25623796
43glyoxylate metabolic process (GO:0046487)3.24200691
44regulation of plasminogen activation (GO:0010755)3.22586937
45regulation of protein activation cascade (GO:2000257)3.20078705
46cell-substrate junction assembly (GO:0007044)3.18728998
47sulfur amino acid catabolic process (GO:0000098)3.17152236
48positive regulation of fatty acid beta-oxidation (GO:0032000)3.16974201
49high-density lipoprotein particle remodeling (GO:0034375)3.15641175
50skin morphogenesis (GO:0043589)3.15382223
51response to gravity (GO:0009629)3.14725853
52Notch signaling involved in heart development (GO:0061314)3.14383675
53tryptophan metabolic process (GO:0006568)3.14367114
54complement activation, alternative pathway (GO:0006957)3.14090588
55positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.11509816
56glucuronate metabolic process (GO:0019585)3.09176202
57uronic acid metabolic process (GO:0006063)3.09176202
58hemidesmosome assembly (GO:0031581)3.08477601
59epoxygenase P450 pathway (GO:0019373)3.03621343
60pattern specification involved in kidney development (GO:0061004)3.02709887
61atrioventricular valve morphogenesis (GO:0003181)3.02510298
62regulation of triglyceride catabolic process (GO:0010896)3.00960843
63regulation of complement activation (GO:0030449)3.00655188
64semaphorin-plexin signaling pathway (GO:0071526)3.00380011
65hypotonic response (GO:0006971)2.99650317
66tyrosine metabolic process (GO:0006570)2.97693576
67vascular endothelial growth factor signaling pathway (GO:0038084)2.97645652
68positive regulation of lipid catabolic process (GO:0050996)2.97386054
69bile acid metabolic process (GO:0008206)2.96322420
70nitrogen cycle metabolic process (GO:0071941)2.96230835
71mesodermal cell differentiation (GO:0048333)2.95187906
72opsonization (GO:0008228)2.94068407
73mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.93428445
74regulation of transforming growth factor beta2 production (GO:0032909)2.93345063
75mammary gland epithelial cell proliferation (GO:0033598)2.92545155
76regulation of axon extension involved in axon guidance (GO:0048841)2.91963137
77fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.90942127
78negative regulation of cholesterol transport (GO:0032375)2.90880050
79negative regulation of sterol transport (GO:0032372)2.90880050
80positive regulation of astrocyte differentiation (GO:0048711)2.90072728
81keratinocyte proliferation (GO:0043616)2.89545459
82facial nerve structural organization (GO:0021612)2.87635274
83barbed-end actin filament capping (GO:0051016)2.86742493
84positive regulation of lipoprotein lipase activity (GO:0051006)2.86547967
85positive regulation of triglyceride lipase activity (GO:0061365)2.86547967
86low-density lipoprotein particle clearance (GO:0034383)2.86016790
87cell adhesion mediated by integrin (GO:0033627)2.85959789
88negative regulation of catenin import into nucleus (GO:0035414)2.85604489
89positive regulation of osteoblast proliferation (GO:0033690)2.84129400
90positive regulation of blood coagulation (GO:0030194)2.80113728
91positive regulation of hemostasis (GO:1900048)2.80113728
92positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.79599931
93reverse cholesterol transport (GO:0043691)2.78890470
94acute-phase response (GO:0006953)2.78696993
95negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.78412284
96aromatic amino acid family metabolic process (GO:0009072)2.78331608
97triglyceride homeostasis (GO:0070328)2.78119347
98acylglycerol homeostasis (GO:0055090)2.78119347
99planar cell polarity pathway involved in neural tube closure (GO:0090179)2.77292858
100desmosome organization (GO:0002934)2.76926584
101type B pancreatic cell proliferation (GO:0044342)2.76901424
102hippo signaling (GO:0035329)2.76690911
103lung vasculature development (GO:0060426)2.76566849
104negative regulation of axon guidance (GO:1902668)2.76422656
105negative regulation of stem cell proliferation (GO:2000647)2.75548707
106endothelial cell morphogenesis (GO:0001886)2.74275716
107cell surface receptor signaling pathway involved in heart development (GO:0061311)2.74143260
108craniofacial suture morphogenesis (GO:0097094)2.71646071
109membrane assembly (GO:0071709)2.71061337
110regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.70829749
111positive regulation of fatty acid biosynthetic process (GO:0045723)2.70711410
112very-low-density lipoprotein particle assembly (GO:0034379)2.70533916
113regulation of cholesterol esterification (GO:0010872)2.70132402
114regulation of membrane protein ectodomain proteolysis (GO:0051043)2.69404870
115wound healing, spreading of cells (GO:0044319)2.67628965
116regulation of keratinocyte proliferation (GO:0010837)2.66638103
117ethanol oxidation (GO:0006069)2.66587427
118positive regulation of extracellular matrix organization (GO:1903055)2.65836973
119cholesterol efflux (GO:0033344)2.65757092
120protein-lipid complex remodeling (GO:0034368)2.64549994
121macromolecular complex remodeling (GO:0034367)2.64549994
122plasma lipoprotein particle remodeling (GO:0034369)2.64549994
123regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.63601086
124negative regulation of cartilage development (GO:0061037)2.62719119
125mammary gland development (GO:0030879)2.62260617
126protein-lipid complex assembly (GO:0065005)2.61992687
127endocardial cushion development (GO:0003197)2.61782778
128axon extension (GO:0048675)2.59644369
129positive regulation of coagulation (GO:0050820)2.59491918
130mesenchymal-epithelial cell signaling (GO:0060638)2.58439202
131regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.58349032
132endothelial cell chemotaxis (GO:0035767)2.57922605
133cellular response to vitamin D (GO:0071305)2.56541051
134plasma lipoprotein particle assembly (GO:0034377)2.55672416
135cholesterol homeostasis (GO:0042632)2.55271520
136regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.55255895
137sterol homeostasis (GO:0055092)2.54397991
138kidney mesenchyme development (GO:0072074)2.53855394
139heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.53806049
140branching involved in mammary gland duct morphogenesis (GO:0060444)2.52450386
141negative regulation of blood coagulation (GO:0030195)2.52401310
142negative regulation of hemostasis (GO:1900047)2.52401310
143positive regulation of p38MAPK cascade (GO:1900745)2.52349862
144endothelial tube morphogenesis (GO:0061154)2.51986435
145morphogenesis of an endothelium (GO:0003159)2.51986435
146negative regulation of fatty acid transport (GO:2000192)2.51755998
147regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.51509856
148cofactor catabolic process (GO:0051187)2.51336919
149arginine metabolic process (GO:0006525)2.50902004
150regulation of axon guidance (GO:1902667)2.50568512
151glutamate metabolic process (GO:0006536)2.50015630
152aldehyde catabolic process (GO:0046185)2.49997450
153coenzyme catabolic process (GO:0009109)2.49522525
154response to laminar fluid shear stress (GO:0034616)2.49343866
155negative regulation of anoikis (GO:2000811)2.48927140
156positive regulation of actin filament depolymerization (GO:0030836)2.48489861
157phospholipid efflux (GO:0033700)2.48435759
158positive regulation of triglyceride metabolic process (GO:0090208)2.48374520
159negative regulation of lipase activity (GO:0060192)2.47214869
160glomerular visceral epithelial cell development (GO:0072015)2.46457620
161wound healing, spreading of epidermal cells (GO:0035313)2.45354674
162positive regulation of axon extension (GO:0045773)2.45096787
163presynaptic membrane assembly (GO:0097105)2.44890240
164regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.44884762
165regulation of heterotypic cell-cell adhesion (GO:0034114)2.44521741
166lipoprotein metabolic process (GO:0042157)2.44438232
167maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.42692916
168cochlea morphogenesis (GO:0090103)2.42252159
169branch elongation of an epithelium (GO:0060602)2.42159750
170basement membrane organization (GO:0071711)2.40579649
171protein localization to microtubule (GO:0035372)2.39443432
172SMAD protein complex assembly (GO:0007183)2.37844799
173regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.37067636
174positive regulation of male gonad development (GO:2000020)2.37052179
175neuron projection extension (GO:1990138)2.35542045
176membrane raft organization (GO:0031579)2.35179487
177notochord development (GO:0030903)2.34383762
178cellular response to vitamin (GO:0071295)2.33254032
179cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.32540160
180anatomical structure arrangement (GO:0048532)2.32423880
181nephron tubule formation (GO:0072079)2.31428411
182neural crest cell development (GO:0014032)2.31144259
183cell proliferation involved in kidney development (GO:0072111)2.30647319
184regulation of positive chemotaxis (GO:0050926)2.30396204
185wound healing (GO:0042060)2.29745966
186protein hydroxylation (GO:0018126)2.29304826
187positive regulation of positive chemotaxis (GO:0050927)2.28567997
188regulation of gonadotropin secretion (GO:0032276)2.28407098
189smooth muscle tissue development (GO:0048745)2.27520446
190Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.25626086
191cranial nerve structural organization (GO:0021604)2.24153297

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.97663424
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.71553039
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.46751146
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.97696790
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.92660630
6* LXR_22158963_ChIP-Seq_LIVER_Mouse3.74206748
7SMAD_19615063_ChIP-ChIP_OVARY_Human3.44927004
8* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.43832385
9RARG_19884340_ChIP-ChIP_MEFs_Mouse3.38036373
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.97261217
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.63385157
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.62721804
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.58215363
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.55147356
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.53092931
16CLOCK_20551151_ChIP-Seq_293T_Human2.44769982
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.28540597
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.27834707
19AR_21909140_ChIP-Seq_LNCAP_Human2.25836047
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.08656201
21* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.07372730
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.04820344
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99201324
24* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.98329168
25CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.89131915
26ZNF263_19887448_ChIP-Seq_K562_Human1.86673255
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.84904881
28* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.81331810
29* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.76563042
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.72000643
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.69121343
32* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.68334195
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66480683
34TP53_16413492_ChIP-PET_HCT116_Human1.66433342
35CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.66329410
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.65425506
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.62360807
38CDX2_20551321_ChIP-Seq_CACO-2_Human1.58773559
39SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.58496778
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.58397065
41* SOX2_20726797_ChIP-Seq_SW620_Human1.55963320
42EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.52446802
43* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50010026
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48643427
45RACK7_27058665_Chip-Seq_MCF-7_Human1.48351880
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48249438
47* ELK3_25401928_ChIP-Seq_HUVEC_Human1.47376075
48SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.46356065
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.46332072
50SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.43911101
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.43911101
52* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.43129811
53* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.43129811
54* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42673795
55CJUN_26792858_Chip-Seq_BT549_Human1.41702146
56* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41551107
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40609268
58CTNNB1_20460455_ChIP-Seq_HCT116_Human1.37485942
59* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36981148
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36430665
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32482230
62TP53_22127205_ChIP-Seq_IMR90_Human1.30748865
63* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29921419
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.28506849
65ATF3_27146783_Chip-Seq_COLON_Human1.28380808
66FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24590671
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23010309
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21927909
69* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20754212
70P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20244824
71ESR1_20079471_ChIP-ChIP_T-47D_Human1.19992761
72SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19354637
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.19129145
74* FOXA2_19822575_ChIP-Seq_HepG2_Human1.18901486
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18517625
76ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18221956
77GATA4_25053715_ChIP-Seq_YYC3_Human1.17775027
78* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17119012
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16575723
80FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16571243
81* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15661678
82EGR1_19374776_ChIP-ChIP_THP-1_Human1.15458548
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14723990
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14685545
85* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14088959
86ELK1_22589737_ChIP-Seq_MCF10A_Human1.13796663
87* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13012575
88MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.12327383
89TP63_23658742_ChIP-Seq_EP156T_Human1.11837463
90* EP300_21415370_ChIP-Seq_HL-1_Mouse1.10597532
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09909606
92TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.09387218
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08849807
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08451078
95SOX17_20123909_ChIP-Seq_XEN_Mouse1.08328366
96* UBF1/2_26484160_Chip-Seq_HMECs_Human1.07622273
97* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06935064
98FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.06686083
99* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06633442
100LXR_22292898_ChIP-Seq_THP-1_Human1.06621652
101WT1_19549856_ChIP-ChIP_CCG9911_Human1.06405314
102NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05825921
103GATA6_25053715_ChIP-Seq_YYC3_Human1.05707546
104VDR_24787735_ChIP-Seq_THP-1_Human1.04575342
105WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03913482
106* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03368326
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02568291
108CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01014245
109* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.00154968
110RUNX1_27514584_Chip-Seq_MCF-7_Human0.99529477
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99204841
112ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98788601
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96965252
114SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95238563
115* TBX20_22080862_ChIP-Seq_HEART_Mouse0.94778205
116* TBX20_22328084_ChIP-Seq_HEART_Mouse0.94778205
117TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93745414
118* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92290443
119KLF5_25053715_ChIP-Seq_YYC3_Human0.92188527
120ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91981829
121* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90737950
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90417934
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90316662
124RXR_22108803_ChIP-Seq_LS180_Human0.90282830
125ELK1_19687146_ChIP-ChIP_HELA_Human0.89491196
126NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89137837
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88926083
128CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87753389
129NFI_21473784_ChIP-Seq_ESCs_Mouse0.86432299
130* SA1_22415368_ChIP-Seq_MEFs_Mouse0.85873390
131TCF4_18268006_ChIP-ChIP_LS174T_Human0.85325735
132BRD4_25478319_ChIP-Seq_HGPS_Human0.84344356
133CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84085181
134* KDM2B_26808549_Chip-Seq_K562_Human0.83574910
135TP53_18474530_ChIP-ChIP_U2OS_Human0.82661392
136ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82466374
137TP53_20018659_ChIP-ChIP_R1E_Mouse0.82277589
138* AHR_22903824_ChIP-Seq_MCF-7_Human0.81987482
139TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81643179
140SMAD3_21741376_ChIP-Seq_HESCs_Human0.81407173
141TP53_23651856_ChIP-Seq_MEFs_Mouse0.81337629
142PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80134405
143KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.79931531
144CREB1_26743006_Chip-Seq_LNCaP_Human0.78726840
145* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.77913894

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.74757339
2MP0005360_urolithiasis4.12987415
3MP0005085_abnormal_gallbladder_physiolo3.58760010
4MP0002877_abnormal_melanocyte_morpholog3.16380670
5MP0005365_abnormal_bile_salt3.03716092
6MP0009840_abnormal_foam_cell2.92078951
7MP0003705_abnormal_hypodermis_morpholog2.88606113
8MP0005083_abnormal_biliary_tract2.78228942
9MP0008875_abnormal_xenobiotic_pharmacok2.68071633
10MP0008438_abnormal_cutaneous_collagen2.55305732
11MP0002089_abnormal_postnatal_growth/wei2.38254515
12MP0004272_abnormal_basement_membrane2.32351831
13MP0003806_abnormal_nucleotide_metabolis2.20704206
14MP0000534_abnormal_ureter_morphology2.11331256
15MP0010329_abnormal_lipoprotein_level2.05104532
16MP0003195_calcinosis2.03618345
17MP0003252_abnormal_bile_duct2.01654645
18MP0010368_abnormal_lymphatic_system1.85939123
19MP0003941_abnormal_skin_development1.84011852
20MP0005409_darkened_coat_color1.83519681
21MP0005275_abnormal_skin_tensile1.80841860
22MP0003303_peritoneal_inflammation1.77453514
23MP0009384_cardiac_valve_regurgitation1.72268013
24MP0003453_abnormal_keratinocyte_physiol1.70599917
25MP0005023_abnormal_wound_healing1.70176774
26MP0001299_abnormal_eye_distance/1.67897312
27MP0003385_abnormal_body_wall1.65823002
28MP0003755_abnormal_palate_morphology1.65816578
29MP0001666_abnormal_nutrient_absorption1.62256475
30MP0000751_myopathy1.56952579
31MP0000467_abnormal_esophagus_morphology1.54124684
32MP0000516_abnormal_urinary_system1.48579106
33MP0005367_renal/urinary_system_phenotyp1.48579106
34MP0003191_abnormal_cellular_cholesterol1.45037090
35MP0003566_abnormal_cell_adhesion1.44596117
36MP0005332_abnormal_amino_acid1.41309663
37MP0003300_gastrointestinal_ulcer1.40874614
38MP0005623_abnormal_meninges_morphology1.39440096
39MP0000609_abnormal_liver_physiology1.38176055
40MP0010352_gastrointestinal_tract_polyps1.36039338
41MP0010234_abnormal_vibrissa_follicle1.35985770
42MP0005248_abnormal_Harderian_gland1.34861036
43MP0003724_increased_susceptibility_to1.33787587
44MP0005451_abnormal_body_composition1.32282323
45MP0001958_emphysema1.31982464
46MP0003091_abnormal_cell_migration1.31647945
47MP0002118_abnormal_lipid_homeostasis1.31238850
48MP0010030_abnormal_orbit_morphology1.31230126
49MP0009780_abnormal_chondrocyte_physiolo1.31217224
50MP0009053_abnormal_anal_canal1.29263827
51MP0000750_abnormal_muscle_regeneration1.29075206
52MP0002060_abnormal_skin_morphology1.28432145
53MP0002295_abnormal_pulmonary_circulatio1.28291608
54MP0006054_spinal_hemorrhage1.28130275
55MP0003279_aneurysm1.23850573
56MP0005257_abnormal_intraocular_pressure1.20713865
57MP0001881_abnormal_mammary_gland1.20143523
58MP0003935_abnormal_craniofacial_develop1.19492305
59MP0000432_abnormal_head_morphology1.17413337
60MP0005076_abnormal_cell_differentiation1.17217245
61MP0002234_abnormal_pharynx_morphology1.15776549
62MP0003315_abnormal_perineum_morphology1.13341383
63MP0002138_abnormal_hepatobiliary_system1.12688322
64MP0005164_abnormal_response_to1.12456810
65MP0008004_abnormal_stomach_pH1.12351093
66MP0002282_abnormal_trachea_morphology1.11557964
67MP0002177_abnormal_outer_ear1.10991592
68MP0002796_impaired_skin_barrier1.10733440
69MP0003436_decreased_susceptibility_to1.09778792
70MP0005503_abnormal_tendon_morphology1.09154772
71MP0004019_abnormal_vitamin_homeostasis1.08534255
72MP0003115_abnormal_respiratory_system1.08320353
73MP0000778_abnormal_nervous_system1.05723085
74MP0002254_reproductive_system_inflammat1.05631888
75MP0005171_absent_coat_pigmentation1.05124104
76MP0005408_hypopigmentation1.04501451
77MP0009764_decreased_sensitivity_to1.03149105
78MP0005501_abnormal_skin_physiology1.02177177
79MP0002233_abnormal_nose_morphology1.01804999
80MP0004782_abnormal_surfactant_physiolog1.01646354
81MP0010771_integument_phenotype1.01630983
82MP0000762_abnormal_tongue_morphology1.01243551
83MP0003937_abnormal_limbs/digits/tail_de1.01224934
84MP0001915_intracranial_hemorrhage1.01035424
85MP0003942_abnormal_urinary_system1.00468133
86MP0004510_myositis1.00228762
87MP0000428_abnormal_craniofacial_morphol0.99919229
88MP0002697_abnormal_eye_size0.99358767
89MP0000733_abnormal_muscle_development0.98591655
90MP0000647_abnormal_sebaceous_gland0.98084696
91MP0005319_abnormal_enzyme/_coenzyme0.97547833
92MP0001243_abnormal_dermal_layer0.96876781
93MP0005193_abnormal_anterior_eye0.95403033
94MP0004858_abnormal_nervous_system0.94329988
95MP0004947_skin_inflammation0.94269409
96MP0010678_abnormal_skin_adnexa0.93330630
97MP0002933_joint_inflammation0.92494638
98MP0002098_abnormal_vibrissa_morphology0.90532853
99MP0002925_abnormal_cardiovascular_devel0.89550300
100MP0000383_abnormal_hair_follicle0.88812706
101MP0005165_increased_susceptibility_to0.87725346
102MP0001533_abnormal_skeleton_physiology0.87000881
103MP0000767_abnormal_smooth_muscle0.86899166
104MP0004185_abnormal_adipocyte_glucose0.86311017
105MP0002896_abnormal_bone_mineralization0.85714222
106MP0005595_abnormal_vascular_smooth0.85673747
107MP0000249_abnormal_blood_vessel0.85553964
108MP0001542_abnormal_bone_strength0.85512951
109MP0003890_abnormal_embryonic-extraembry0.85237511
110MP0005508_abnormal_skeleton_morphology0.84633657
111MP0000537_abnormal_urethra_morphology0.83594587
112MP0002116_abnormal_craniofacial_bone0.83148408
113MP0001879_abnormal_lymphatic_vessel0.83104395
114MP0000462_abnormal_digestive_system0.82564018
115MP0002092_abnormal_eye_morphology0.82204163
116MP0001614_abnormal_blood_vessel0.82086280
117MP0001346_abnormal_lacrimal_gland0.81335558
118MP0001286_abnormal_eye_development0.79982247
119MP0000579_abnormal_nail_morphology0.79965615
120MP0005197_abnormal_uvea_morphology0.78287469
121MP0000604_amyloidosis0.77825500
122MP0004883_abnormal_blood_vessel0.77213595
123MP0000598_abnormal_liver_morphology0.76794940
124MP0005166_decreased_susceptibility_to0.76489358
125MP0000749_muscle_degeneration0.76432065
126MP0001216_abnormal_epidermal_layer0.75468445
127MP0000627_abnormal_mammary_gland0.75210525
128MP0005187_abnormal_penis_morphology0.75091143
129MP0002332_abnormal_exercise_endurance0.74944562
130MP0000566_synostosis0.74251904
131MP0002109_abnormal_limb_morphology0.73869625
132MP0003634_abnormal_glial_cell0.73724421
133MP0001849_ear_inflammation0.73689147
134MP0002932_abnormal_joint_morphology0.73240539
135MP0000163_abnormal_cartilage_morphology0.73163439
136MP0000920_abnormal_myelination0.73120995
137MP0003950_abnormal_plasma_membrane0.72790654
138MP0003329_amyloid_beta_deposits0.72485107
139MP0009643_abnormal_urine_homeostasis0.72356030
140MP0003075_altered_response_to0.72128412
141MP0005084_abnormal_gallbladder_morpholo0.71530342
142MP0004197_abnormal_fetal_growth/weight/0.71183515
143MP0002168_other_aberrant_phenotype0.71131569
144MP0009250_abnormal_appendicular_skeleto0.71003028
145MP0005390_skeleton_phenotype0.70834971
146MP0002998_abnormal_bone_remodeling0.70672306
147MP0000858_altered_metastatic_potential0.70434544
148MP0005375_adipose_tissue_phenotype0.70222906
149MP0000343_altered_response_to0.69806985
150MP0001340_abnormal_eyelid_morphology0.69705326
151MP0002085_abnormal_embryonic_tissue0.69324030
152MP0003943_abnormal_hepatobiliary_system0.69199715
153MP0002133_abnormal_respiratory_system0.68153053

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.51920208
2Intrahepatic cholestasis (HP:0001406)4.78422666
3Xanthomatosis (HP:0000991)4.55838243
4Premature rupture of membranes (HP:0001788)4.41017648
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.30572671
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.29742055
7Atrophic scars (HP:0001075)3.87156436
8Arterial tortuosity (HP:0005116)3.78316249
9Protrusio acetabuli (HP:0003179)3.72450763
10Myocardial infarction (HP:0001658)3.57741129
11Prolonged partial thromboplastin time (HP:0003645)3.54048997
12Hyperlipoproteinemia (HP:0010980)3.37712090
13Vascular tortuosity (HP:0004948)3.34892984
14Peritonitis (HP:0002586)3.32389411
15Right ventricular cardiomyopathy (HP:0011663)3.29195631
16Hypobetalipoproteinemia (HP:0003563)3.23562708
17Vascular calcification (HP:0004934)3.18812863
18Follicular hyperkeratosis (HP:0007502)3.16658517
19Abnormality of the common coagulation pathway (HP:0010990)3.14020382
20Cardiovascular calcification (HP:0011915)3.11586622
21Complement deficiency (HP:0004431)3.05905025
22Joint hemorrhage (HP:0005261)2.97932469
23Interstitial pulmonary disease (HP:0006530)2.96479641
24Hypoalphalipoproteinemia (HP:0003233)2.94324824
25Ankle contracture (HP:0006466)2.92191943
26Shallow orbits (HP:0000586)2.83402699
27Hypolipoproteinemia (HP:0010981)2.81284579
28Esophageal varix (HP:0002040)2.80572118
29Natal tooth (HP:0000695)2.74969690
30Onycholysis (HP:0001806)2.74050504
31Abnormality of complement system (HP:0005339)2.71570226
32Ileus (HP:0002595)2.68420206
33Fat malabsorption (HP:0002630)2.67626161
34Hemorrhage of the eye (HP:0011885)2.66082226
35Abnormality of glutamine family amino acid metabolism (HP:0010902)2.65644760
36Reduced subcutaneous adipose tissue (HP:0003758)2.64640411
37Milia (HP:0001056)2.63094934
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.61402385
39Upper limb muscle weakness (HP:0003484)2.60176366
40Epidermoid cyst (HP:0200040)2.59945620
41Turricephaly (HP:0000262)2.59334864
42Cervical subluxation (HP:0003308)2.47975363
43Microglossia (HP:0000171)2.43528159
44Axonal loss (HP:0003447)2.41086113
45Polycythemia (HP:0001901)2.34570751
46Neonatal short-limb short stature (HP:0008921)2.30394958
47Coronal craniosynostosis (HP:0004440)2.28687114
48Neurofibrillary tangles (HP:0002185)2.27858870
49Fragile skin (HP:0001030)2.27221015
50Nail dystrophy (HP:0008404)2.27028400
51Hypercholesterolemia (HP:0003124)2.26972871
52Fragile nails (HP:0001808)2.26418424
53Malnutrition (HP:0004395)2.25081674
54Insomnia (HP:0100785)2.23046225
55Plantar hyperkeratosis (HP:0007556)2.22459038
56Broad metatarsal (HP:0001783)2.22393045
57Small epiphyses (HP:0010585)2.21162288
58Upper limb amyotrophy (HP:0009129)2.21011667
59Distal upper limb amyotrophy (HP:0007149)2.21011667
60Abnormality of the Achilles tendon (HP:0005109)2.19786577
61Hypophosphatemic rickets (HP:0004912)2.17825624
62Deviation of the thumb (HP:0009603)2.17670515
63Focal segmental glomerulosclerosis (HP:0000097)2.17144735
64Respiratory distress (HP:0002098)2.16425133
65Hand muscle atrophy (HP:0009130)2.13780485
66Abnormality of the intrinsic pathway (HP:0010989)2.13684234
67Bladder diverticulum (HP:0000015)2.13517744
68Amyloidosis (HP:0011034)2.13432778
69Bronchomalacia (HP:0002780)2.12454710
70Alopecia of scalp (HP:0002293)2.12432459
71Steatorrhea (HP:0002570)2.09566263
72Menorrhagia (HP:0000132)2.09278304
73Limb-girdle muscle atrophy (HP:0003797)2.09171513
74Blue sclerae (HP:0000592)2.07214002
75Infantile muscular hypotonia (HP:0008947)2.07172716
76Pterygium (HP:0001059)2.06960094
77Abnormal auditory evoked potentials (HP:0006958)2.06422019
78Mitral stenosis (HP:0001718)2.05868667
79Selective tooth agenesis (HP:0001592)2.05320616
80Aortic aneurysm (HP:0004942)2.04986499
81Mitral valve prolapse (HP:0001634)2.04894308
82Skin nodule (HP:0200036)2.03673862
83Generalized amyotrophy (HP:0003700)2.03430152
84Abnormality of sulfur amino acid metabolism (HP:0004339)2.03266531
85Syringomyelia (HP:0003396)2.01788281
86Spinal cord lesions (HP:0100561)2.01788281
87Elbow flexion contracture (HP:0002987)2.01687601
88Glomerulosclerosis (HP:0000096)2.01642867
89Hyperammonemia (HP:0001987)2.01203036
90Protruding ear (HP:0000411)2.00810134
91Wormian bones (HP:0002645)1.99595739
92Sparse lateral eyebrow (HP:0005338)1.99558748
93Aortic dissection (HP:0002647)1.98284953
94Increased connective tissue (HP:0009025)1.97256590
95Hepatocellular carcinoma (HP:0001402)1.96543223
96Vertebral arch anomaly (HP:0008438)1.96499519
97Tetraparesis (HP:0002273)1.95522426
98Spondylolisthesis (HP:0003302)1.92948892
99Abnormal hemoglobin (HP:0011902)1.92127535
100Increased serum ferritin (HP:0003281)1.91961950
101Cerebral aneurysm (HP:0004944)1.91754166
102Hyperacusis (HP:0010780)1.91498906
103Proximal placement of thumb (HP:0009623)1.91351541
104Arnold-Chiari malformation (HP:0002308)1.90964683
105Abnormality of the distal phalanges of the toes (HP:0010182)1.90915405
106Parakeratosis (HP:0001036)1.88825948
107Thick nail (HP:0001805)1.88063943
108Osteolytic defects of the hand bones (HP:0009699)1.86199561
109Osteolytic defects of the phalanges of the hand (HP:0009771)1.86199561
110Abnormal cartilage morphology (HP:0002763)1.86110168
111Vertebral compression fractures (HP:0002953)1.85925594
112Abnormality of the umbilical cord (HP:0010881)1.85437543
113Abnormality of iron homeostasis (HP:0011031)1.84693402
114Achilles tendon contracture (HP:0001771)1.83541814
115Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.81641200
116Vertebral hypoplasia (HP:0008417)1.81641200
117Tibial bowing (HP:0002982)1.81376652
118Increased mean platelet volume (HP:0011877)1.80273801
119Abnormal delivery (HP:0001787)1.79787212
120Absent frontal sinuses (HP:0002688)1.79063966
121Cerebral inclusion bodies (HP:0100314)1.78781000
122Ankyloglossia (HP:0010296)1.78008387
123Hypoplasia of the iris (HP:0007676)1.76657286
124Mildly elevated creatine phosphokinase (HP:0008180)1.76047275
125Abnormality of oral frenula (HP:0000190)1.75907925
126Rickets (HP:0002748)1.75895006
127Spastic diplegia (HP:0001264)1.75544223
128Ulnar bowing (HP:0003031)1.75500350
129Broad face (HP:0000283)1.75335548
130Soft skin (HP:0000977)1.75095425
131Advanced eruption of teeth (HP:0006288)1.74679767
132Entropion (HP:0000621)1.74641421
133Short nail (HP:0001799)1.74612925
134Limb-girdle muscle weakness (HP:0003325)1.74487906
135Hydroxyprolinuria (HP:0003080)1.74195670
136Abnormality of proline metabolism (HP:0010907)1.74195670
137Abnormality of the musculature of the pelvis (HP:0001469)1.73844661
138Abnormality of the hip-girdle musculature (HP:0001445)1.73844661
139Ectopia lentis (HP:0001083)1.73646318
140Aplasia cutis congenita (HP:0001057)1.73361213
141Protuberant abdomen (HP:0001538)1.72358288
142Abnormal umbilical cord blood vessels (HP:0011403)1.71014622
143Single umbilical artery (HP:0001195)1.71014622
144Abnormality of the fetal cardiovascular system (HP:0010948)1.71014622
145Abnormality of transition element cation homeostasis (HP:0011030)1.70833842
146Back pain (HP:0003418)1.70565052
147Nephritis (HP:0000123)1.69608340
148Aneurysm (HP:0002617)1.69441349
149Spinal rigidity (HP:0003306)1.69220625
150Ketosis (HP:0001946)1.68395094
151Increased density of long bones (HP:0006392)1.67447203
152Aplasia involving bones of the upper limbs (HP:0009823)1.66009822
153Aplasia of the phalanges of the hand (HP:0009802)1.66009822
154Aplasia involving bones of the extremities (HP:0009825)1.66009822
155Hypoglycemic coma (HP:0001325)1.65539580
156Abnormality of methionine metabolism (HP:0010901)1.63288445
157Conjugated hyperbilirubinemia (HP:0002908)1.62649758
158Flat acetabular roof (HP:0003180)1.62400775
159Adactyly (HP:0009776)1.61332859
160Short clavicles (HP:0000894)1.60732687
161Skull defect (HP:0001362)1.60228841
162Abnormality of dentin (HP:0010299)1.59282570
163Open mouth (HP:0000194)1.58712826
164Hypopigmentation of the fundus (HP:0007894)1.58341901
165Hydroureter (HP:0000072)1.57783033
166Abnormality of carpal bone ossification (HP:0006257)1.57684755
167Aplasia/Hypoplasia of the clavicles (HP:0006710)1.54931788
168Long toe (HP:0010511)1.52716673
169Palmar hyperkeratosis (HP:0010765)1.52627150
170Aplasia/Hypoplasia of the breasts (HP:0010311)1.52226830
171Subacute progressive viral hepatitis (HP:0006572)1.52218994
172Shoulder girdle muscle weakness (HP:0003547)1.51764325

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.42868841
2ERN13.74704028
3SIK13.36086081
4EPHB13.30431011
5LMTK22.99121568
6NTRK12.56476313
7TRIB32.43521530
8MKNK22.33575977
9STK392.30249827
10MST1R2.12503749
11BMX2.11555986
12LATS12.06498734
13FGFR41.97165520
14EPHB21.92289511
15MET1.92169292
16ERBB31.87979918
17EPHA31.83083441
18ERBB41.78475796
19FER1.70822793
20LATS21.70657506
21PTK61.65881630
22PIM21.64305571
23WEE11.63159322
24DDR21.61640566
25PTK21.52741913
26MST41.50390396
27MAP3K31.41267316
28WNK41.38623060
29STK38L1.37458933
30BUB11.35187426
31PKN21.34184619
32DYRK1B1.30459864
33TAOK21.28975719
34LRRK21.27408928
35MAP3K121.27277787
36TBK11.25514530
37NME21.25276490
38PAK21.25133865
39MAP2K21.22038137
40TTN1.16015809
41FLT31.12853316
42DMPK1.12695682
43SIK31.09764763
44MARK11.09669031
45PIK3CA1.09472047
46TAOK11.09163692
47KDR1.08103743
48TRIM281.07731807
49RIPK11.06653404
50ABL21.06281562
51ERBB21.05167080
52LIMK11.03753305
53MAPK151.02057323
54EPHA41.02014434
55AKT31.00499872
56PBK1.00029068
57CSK0.99760340
58PDGFRA0.98261596
59TESK20.97422037
60FGFR20.95885533
61MAP3K100.94153628
62CDK80.93633137
63EIF2AK10.92316266
64PNCK0.92196641
65MKNK10.92178510
66MAP3K110.91331618
67TESK10.91257675
68STK100.91114663
69PAK30.87373606
70MOS0.87362014
71ICK0.86405654
72TAOK30.85954502
73PAK40.85144478
74IRAK20.84233975
75NEK90.83156445
76CDK60.83122125
77STK30.82771608
78EIF2AK30.82650163
79PDGFRB0.82551645
80PRKG20.82185359
81ARAF0.81995441
82GSK3A0.81608162
83RPS6KA40.79880906
84BCKDK0.79710539
85TRPM70.78087577
86MAP3K140.77503259
87TGFBR10.75324578
88EIF2AK20.74504593
89PRKD10.73038749
90CHUK0.72454094
91KSR10.72203207
92CLK10.69478294
93ROCK20.69461971
94WNK10.69098937
95MTOR0.68082254
96NLK0.68034401
97PHKG10.66322240
98PHKG20.66322240
99BCR0.65367159
100ROCK10.64923930
101PTK2B0.64826261
102PLK20.64822639
103STK380.64359274
104DAPK30.63212634
105MAP3K10.62461828
106NEK10.61938661
107MAP2K10.61101663
108IRAK30.58052967
109MYLK0.57927778
110MELK0.57266451
111IRAK10.56788706
112ILK0.55995258
113PAK60.55713771
114SRPK10.54112643
115NUAK10.52015953
116CAMK1G0.51544761
117TGFBR20.47883244
118MAP3K20.45602994
119FGFR10.45513806
120CSNK1A1L0.45422358
121CAMK2D0.45366032
122IKBKB0.45232211
123PIK3CG0.45189375
124MAP3K90.44101372
125PRKD20.44016238
126INSR0.43907820
127MAP3K70.43450464
128PRKD30.42778493
129MATK0.41836759
130TIE10.41376656
131OXSR10.40524981
132EGFR0.40185869
133TNIK0.40142682
134ABL10.39704576
135JAK10.38288467
136CAMK2G0.37704777
137BMPR1B0.37596789
138MAP2K70.37102873
139MAPKAPK20.36663715
140IKBKE0.36438710
141MAP3K80.35058261
142BRD40.33495226
143ADRBK10.30508633
144BRSK10.30163383
145GRK70.29032800
146NEK20.28439679
147PRKCE0.28213805
148CDK180.27180800
149TSSK60.26866915
150PLK30.23818056

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.90649802
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.08381377
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.76134455
4Nitrogen metabolism_Homo sapiens_hsa009102.66337985
5Complement and coagulation cascades_Homo sapiens_hsa046102.54074791
6Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.50912665
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.41661305
8Arginine biosynthesis_Homo sapiens_hsa002202.33913826
9Tryptophan metabolism_Homo sapiens_hsa003802.10433655
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.02621975
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97646769
12Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96667755
13Chemical carcinogenesis_Homo sapiens_hsa052041.93919778
14Fatty acid degradation_Homo sapiens_hsa000711.92620553
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88826847
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84742251
17Steroid biosynthesis_Homo sapiens_hsa001001.82726586
18Histidine metabolism_Homo sapiens_hsa003401.82492639
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.81662361
20Sulfur metabolism_Homo sapiens_hsa009201.71768986
21PPAR signaling pathway_Homo sapiens_hsa033201.71690160
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.66548452
23Axon guidance_Homo sapiens_hsa043601.60896679
24Staphylococcus aureus infection_Homo sapiens_hsa051501.57789231
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55290034
26Caffeine metabolism_Homo sapiens_hsa002321.52710541
27Peroxisome_Homo sapiens_hsa041461.51672180
28ECM-receptor interaction_Homo sapiens_hsa045121.50887299
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.50557043
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47682081
31Retinol metabolism_Homo sapiens_hsa008301.43369020
32Butanoate metabolism_Homo sapiens_hsa006501.43049144
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.41831956
34Fatty acid elongation_Homo sapiens_hsa000621.35574817
35p53 signaling pathway_Homo sapiens_hsa041151.35539008
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33470719
37Malaria_Homo sapiens_hsa051441.32937113
38Fatty acid metabolism_Homo sapiens_hsa012121.29923157
39Bladder cancer_Homo sapiens_hsa052191.26539204
40Tyrosine metabolism_Homo sapiens_hsa003501.25488227
41Bile secretion_Homo sapiens_hsa049761.25321428
42ErbB signaling pathway_Homo sapiens_hsa040121.24206338
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.22960206
44Wnt signaling pathway_Homo sapiens_hsa043101.20720675
45Melanoma_Homo sapiens_hsa052181.20165559
46Dilated cardiomyopathy_Homo sapiens_hsa054141.19283117
47Amoebiasis_Homo sapiens_hsa051461.15136906
48Endometrial cancer_Homo sapiens_hsa052131.13002898
49beta-Alanine metabolism_Homo sapiens_hsa004101.12582036
50Fat digestion and absorption_Homo sapiens_hsa049751.12151160
51Thyroid cancer_Homo sapiens_hsa052161.11088494
52Pathways in cancer_Homo sapiens_hsa052001.09480143
53Phenylalanine metabolism_Homo sapiens_hsa003601.07810823
54Pancreatic cancer_Homo sapiens_hsa052121.06522967
55Sulfur relay system_Homo sapiens_hsa041221.06044958
56Starch and sucrose metabolism_Homo sapiens_hsa005001.03826897
57Glioma_Homo sapiens_hsa052141.03678076
58Colorectal cancer_Homo sapiens_hsa052101.02893540
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00803645
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00526147
61Shigellosis_Homo sapiens_hsa051311.00211609
62Adherens junction_Homo sapiens_hsa045200.97989124
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97342667
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.94433714
65Hedgehog signaling pathway_Homo sapiens_hsa043400.91097770
66Focal adhesion_Homo sapiens_hsa045100.90954471
67Arginine and proline metabolism_Homo sapiens_hsa003300.90837225
68Selenocompound metabolism_Homo sapiens_hsa004500.89771479
69Proteoglycans in cancer_Homo sapiens_hsa052050.89434325
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89024935
71Cell cycle_Homo sapiens_hsa041100.85792441
72Glutathione metabolism_Homo sapiens_hsa004800.85201930
73Notch signaling pathway_Homo sapiens_hsa043300.84835462
74Endocytosis_Homo sapiens_hsa041440.83645946
75Folate biosynthesis_Homo sapiens_hsa007900.82607312
76Vibrio cholerae infection_Homo sapiens_hsa051100.82215146
77Pentose phosphate pathway_Homo sapiens_hsa000300.82153992
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81832341
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80367626
80Propanoate metabolism_Homo sapiens_hsa006400.80321366
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80028654
82N-Glycan biosynthesis_Homo sapiens_hsa005100.79419505
83Melanogenesis_Homo sapiens_hsa049160.78273418
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77759625
85Proteasome_Homo sapiens_hsa030500.76235064
86Rap1 signaling pathway_Homo sapiens_hsa040150.75689403
87Basal transcription factors_Homo sapiens_hsa030220.75110106
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74840187
89Sphingolipid metabolism_Homo sapiens_hsa006000.71842059
90Small cell lung cancer_Homo sapiens_hsa052220.70143577
91Estrogen signaling pathway_Homo sapiens_hsa049150.70099811
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.69946299
93Apoptosis_Homo sapiens_hsa042100.69822193
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69657748
95Gap junction_Homo sapiens_hsa045400.69141390
96Lysine degradation_Homo sapiens_hsa003100.68630328
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.67182274
98Tight junction_Homo sapiens_hsa045300.66516878
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66428404
100Prion diseases_Homo sapiens_hsa050200.65957608
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65023661
102Pyruvate metabolism_Homo sapiens_hsa006200.60566255
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60553088
104Hippo signaling pathway_Homo sapiens_hsa043900.60115278
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59689084
106Dorso-ventral axis formation_Homo sapiens_hsa043200.59587353
107TGF-beta signaling pathway_Homo sapiens_hsa043500.58920761
108ABC transporters_Homo sapiens_hsa020100.58043427
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57749663
110TNF signaling pathway_Homo sapiens_hsa046680.57116186
111Thyroid hormone synthesis_Homo sapiens_hsa049180.56185235
112Hepatitis B_Homo sapiens_hsa051610.56056886
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.55360837
114Renal cell carcinoma_Homo sapiens_hsa052110.53618144
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53181533
116Rheumatoid arthritis_Homo sapiens_hsa053230.52662934
117HIF-1 signaling pathway_Homo sapiens_hsa040660.51825112
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.51409775
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50871736
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50214558
121Insulin resistance_Homo sapiens_hsa049310.49646125
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49404304
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.48853941
124Vitamin digestion and absorption_Homo sapiens_hsa049770.48387976
125Basal cell carcinoma_Homo sapiens_hsa052170.47515197
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47180308
127Ras signaling pathway_Homo sapiens_hsa040140.46763257
128Nucleotide excision repair_Homo sapiens_hsa034200.46376438
129Leishmaniasis_Homo sapiens_hsa051400.46240032
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45121269
131Carbon metabolism_Homo sapiens_hsa012000.43959331
132Non-small cell lung cancer_Homo sapiens_hsa052230.43780211
133VEGF signaling pathway_Homo sapiens_hsa043700.43711099
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.43480032
135Toxoplasmosis_Homo sapiens_hsa051450.42487110
136Maturity onset diabetes of the young_Homo sapiens_hsa049500.41888720
137Pertussis_Homo sapiens_hsa051330.40956628
138Circadian rhythm_Homo sapiens_hsa047100.40585058
139Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40006081
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39378492
141Non-homologous end-joining_Homo sapiens_hsa034500.39010493
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37983757
143Protein export_Homo sapiens_hsa030600.37913087
144Cocaine addiction_Homo sapiens_hsa050300.37374454
145Mineral absorption_Homo sapiens_hsa049780.37207107
146PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36802998
147Chronic myeloid leukemia_Homo sapiens_hsa052200.36341348
148Oocyte meiosis_Homo sapiens_hsa041140.35476461
149Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35221364
150HTLV-I infection_Homo sapiens_hsa051660.34921538
151Fatty acid biosynthesis_Homo sapiens_hsa000610.34853797
152Biosynthesis of amino acids_Homo sapiens_hsa012300.34773026
153Galactose metabolism_Homo sapiens_hsa000520.34426895
154Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34033973
155MicroRNAs in cancer_Homo sapiens_hsa052060.34025914
156Protein digestion and absorption_Homo sapiens_hsa049740.33772845
157Prostate cancer_Homo sapiens_hsa052150.31961143
158Salmonella infection_Homo sapiens_hsa051320.31144529
159Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30094271
160Hepatitis C_Homo sapiens_hsa051600.29991050
161Cyanoamino acid metabolism_Homo sapiens_hsa004600.29436010
1622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29193188
163Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28434715
164Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28295215
165Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26623945

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