PHLDA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)6.20654450
2Golgi transport vesicle coating (GO:0048200)4.98016210
3COPI coating of Golgi vesicle (GO:0048205)4.98016210
4mitotic nuclear envelope reassembly (GO:0007084)4.90128337
5nuclear envelope reassembly (GO:0031468)4.90128337
6regulation of posttranscriptional gene silencing (GO:0060147)4.87213070
7regulation of gene silencing by miRNA (GO:0060964)4.87213070
8regulation of gene silencing by RNA (GO:0060966)4.87213070
9DNA replication initiation (GO:0006270)4.85418957
10nucleobase biosynthetic process (GO:0046112)4.72805396
11maturation of SSU-rRNA (GO:0030490)4.66049054
12ribosome assembly (GO:0042255)4.64962812
13folic acid-containing compound biosynthetic process (GO:0009396)4.53707703
14protein retention in ER lumen (GO:0006621)4.52700342
15purine nucleobase biosynthetic process (GO:0009113)4.51600993
16negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.46981859
17maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.46551468
18IMP biosynthetic process (GO:0006188)4.38579503
19DNA strand elongation involved in DNA replication (GO:0006271)4.35224416
20nuclear pore organization (GO:0006999)4.29677536
21mitotic metaphase plate congression (GO:0007080)4.29390061
22DNA unwinding involved in DNA replication (GO:0006268)4.28255174
23skin morphogenesis (GO:0043589)4.24883262
24establishment of viral latency (GO:0019043)4.22761761
25DNA strand elongation (GO:0022616)4.12140556
26mitotic nuclear envelope disassembly (GO:0007077)4.10883939
27ribosome biogenesis (GO:0042254)4.10767682
28DNA replication-dependent nucleosome assembly (GO:0006335)4.08375514
29DNA replication-dependent nucleosome organization (GO:0034723)4.08375514
30ribosomal small subunit assembly (GO:0000028)4.07245204
31proteasome assembly (GO:0043248)4.00573669
32hemidesmosome assembly (GO:0031581)3.98097753
33formation of translation preinitiation complex (GO:0001731)3.97955794
34membrane raft organization (GO:0031579)3.96030713
35nuclear pore complex assembly (GO:0051292)3.95538328
36ribonucleoprotein complex biogenesis (GO:0022613)3.90817393
37telomere maintenance via semi-conservative replication (GO:0032201)3.90611487
38DNA replication checkpoint (GO:0000076)3.90433618
39muscle cell migration (GO:0014812)3.88201266
40regulation of metalloenzyme activity (GO:0048552)3.87988094
41IMP metabolic process (GO:0046040)3.86370121
42membrane disassembly (GO:0030397)3.81653670
43nuclear envelope disassembly (GO:0051081)3.81653670
44ribosomal small subunit biogenesis (GO:0042274)3.80874324
45protein localization to kinetochore (GO:0034501)3.78739278
46ribosomal large subunit biogenesis (GO:0042273)3.77244404
47viral transcription (GO:0019083)3.75195481
48translational termination (GO:0006415)3.74129025
49desmosome organization (GO:0002934)3.69469628
50GDP-mannose metabolic process (GO:0019673)3.67767659
51nucleobase-containing small molecule interconversion (GO:0015949)3.66561378
52chromatin remodeling at centromere (GO:0031055)3.65932838
53regulation of mesoderm development (GO:2000380)3.63427996
54CENP-A containing nucleosome assembly (GO:0034080)3.63260540
55pre-miRNA processing (GO:0031054)3.62742073
56metaphase plate congression (GO:0051310)3.60225068
57establishment of integrated proviral latency (GO:0075713)3.55498880
58paraxial mesoderm development (GO:0048339)3.53750937
59regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.53132047
60spliceosomal snRNP assembly (GO:0000387)3.52919474
61rRNA processing (GO:0006364)3.51397290
62translational initiation (GO:0006413)3.49656566
63negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.48775453
64DNA deamination (GO:0045006)3.46890651
65translational elongation (GO:0006414)3.45281666
66rRNA modification (GO:0000154)3.44086558
67protein K6-linked ubiquitination (GO:0085020)3.43779263
68nodal signaling pathway (GO:0038092)3.42059194
69telomere maintenance via recombination (GO:0000722)3.41410954
70rRNA metabolic process (GO:0016072)3.40043507
71protein localization to endosome (GO:0036010)3.39594198
72DNA replication-independent nucleosome organization (GO:0034724)3.33232754
73DNA replication-independent nucleosome assembly (GO:0006336)3.33232754
74positive regulation of actin filament depolymerization (GO:0030836)3.31078108
75cell migration involved in gastrulation (GO:0042074)3.27339972
76nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.26767363
77telomere maintenance via telomere lengthening (GO:0010833)3.25104707
78protein localization to chromosome, centromeric region (GO:0071459)3.22588026
79type B pancreatic cell proliferation (GO:0044342)3.22585100
80barbed-end actin filament capping (GO:0051016)3.19651644
81mitotic recombination (GO:0006312)3.17454553
82extracellular fibril organization (GO:0043206)3.16237948
83kinetochore organization (GO:0051383)3.16091397
84spliceosomal complex assembly (GO:0000245)3.16076536
85histone exchange (GO:0043486)3.15512059
86folic acid metabolic process (GO:0046655)3.15335947
87cell adhesion mediated by integrin (GO:0033627)3.13867523
88maturation of 5.8S rRNA (GO:0000460)3.12848808
89deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.12406372
90kinetochore assembly (GO:0051382)3.12263815
91regulation of helicase activity (GO:0051095)3.11855165
92regulation of spindle organization (GO:0090224)3.11128857
93pseudouridine synthesis (GO:0001522)3.11111445
94establishment of chromosome localization (GO:0051303)3.10601671
95histone arginine methylation (GO:0034969)3.09186795
96transcription-coupled nucleotide-excision repair (GO:0006283)3.08854355
97cellular copper ion homeostasis (GO:0006878)3.06862677
98mesodermal cell differentiation (GO:0048333)3.04763264
99blastocyst development (GO:0001824)3.03558504
100lipopolysaccharide biosynthetic process (GO:0009103)3.03369212
101peptidyl-arginine omega-N-methylation (GO:0035247)3.03255587
102response to gravity (GO:0009629)3.03124694
103actin filament depolymerization (GO:0030042)3.03037259
104negative regulation of chromosome segregation (GO:0051985)3.01621376
105pyrimidine-containing compound salvage (GO:0008655)3.01215746
106pyrimidine nucleoside salvage (GO:0043097)3.01215746
107termination of RNA polymerase III transcription (GO:0006386)3.00170504
108transcription elongation from RNA polymerase III promoter (GO:0006385)3.00170504
109mitotic sister chromatid segregation (GO:0000070)2.99885210
110protein complex localization (GO:0031503)2.98520867
111negative regulation of mitotic sister chromatid separation (GO:2000816)2.98252299
112negative regulation of mitotic sister chromatid segregation (GO:0033048)2.98252299
113negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.98252299
114negative regulation of sister chromatid segregation (GO:0033046)2.98252299
115SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.97179537
116regulation of translational termination (GO:0006449)2.95865953
117cellular protein complex disassembly (GO:0043624)2.95083743
118somatic diversification of immune receptors via somatic mutation (GO:0002566)2.94848788
119somatic hypermutation of immunoglobulin genes (GO:0016446)2.94848788
120regulation of centrosome cycle (GO:0046605)2.92321647
121negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.91646104
122transcription from RNA polymerase I promoter (GO:0006360)2.91363173
123negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90948385
124pore complex assembly (GO:0046931)2.90872945
125morphogenesis of an endothelium (GO:0003159)2.89736013
126endothelial tube morphogenesis (GO:0061154)2.89736013
127spindle checkpoint (GO:0031577)2.88869355
128cotranslational protein targeting to membrane (GO:0006613)2.88851091
129pteridine-containing compound biosynthetic process (GO:0042559)2.88374682
130endothelial cell morphogenesis (GO:0001886)2.88084822
131protein targeting to ER (GO:0045047)2.87915163
132mitotic spindle assembly checkpoint (GO:0007094)2.87526577
133viral life cycle (GO:0019058)2.86888990
134DNA duplex unwinding (GO:0032508)2.86353522
135DNA geometric change (GO:0032392)2.86111036
136negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.85552806
137negative regulation of ligase activity (GO:0051352)2.85552806
138mitotic spindle checkpoint (GO:0071174)2.84369166
139nucleotide-excision repair, DNA gap filling (GO:0006297)2.83757419
140retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.78104128
141positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.75859918
142negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.74510576
143fibril organization (GO:0097435)2.74485218
144regulation of cellular amino acid metabolic process (GO:0006521)2.73114610
145proline biosynthetic process (GO:0006561)2.72540509
146nucleoside salvage (GO:0043174)2.69964996
147anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.67599727
148regulation of mammary gland epithelial cell proliferation (GO:0033599)2.66750317
149virion assembly (GO:0019068)2.65658852
150nucleotide-sugar biosynthetic process (GO:0009226)2.65000029
151regulation of apoptotic process involved in morphogenesis (GO:1902337)2.64449653
152regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.62323790
153positive regulation of pseudopodium assembly (GO:0031274)2.62155720
154substrate-dependent cell migration (GO:0006929)2.61863547
155dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.59424840
156glucose catabolic process (GO:0006007)2.58750169
157regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.58353231
158negative regulation of mitochondrion organization (GO:0010823)2.58181296
159positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.57706435
160lung morphogenesis (GO:0060425)2.57051309
161protein hydroxylation (GO:0018126)2.55482968
162regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.55122190
163pattern specification involved in kidney development (GO:0061004)2.53250604
164lung vasculature development (GO:0060426)2.52427442
165positive regulation of epidermis development (GO:0045684)2.52151794
166negative regulation of chondrocyte differentiation (GO:0032331)2.51842598
167positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.51384214
168DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.51286455
169heterochromatin organization (GO:0070828)2.51108578
170cell-substrate junction assembly (GO:0007044)2.51105257
171protein targeting to mitochondrion (GO:0006626)2.50611125
172chaperone-mediated protein transport (GO:0072321)2.48530901
173negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.47807584
174pinocytosis (GO:0006907)2.46713982
175positive regulation of epidermal cell differentiation (GO:0045606)2.46620022
176fibrinolysis (GO:0042730)2.46258341
177signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.46240832
178intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.46240832
179endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.46036162
180antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.45446303
181hypotonic response (GO:0006971)2.44754117
182guanosine-containing compound biosynthetic process (GO:1901070)2.43994174
183positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.42976441
184embryonic skeletal joint morphogenesis (GO:0060272)2.42882068
185regulation of mitochondrial translation (GO:0070129)2.42763883
186negative regulation of nitric-oxide synthase activity (GO:0051001)2.41134186
187pentose-phosphate shunt (GO:0006098)2.40962507
188signal transduction involved in DNA integrity checkpoint (GO:0072401)2.39338180
189signal transduction involved in DNA damage checkpoint (GO:0072422)2.39338180
190endothelial cell chemotaxis (GO:0035767)2.39066170
191response to progesterone (GO:0032570)2.38428851
192signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.38218906
193signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.38218906
194signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.38218906

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.83730277
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.78070952
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.07613653
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.65266346
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.45875600
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.44719429
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.28364224
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.27243804
9RARG_19884340_ChIP-ChIP_MEFs_Mouse3.27171074
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.08307139
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.92716796
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.86688103
13ZNF263_19887448_ChIP-Seq_K562_Human2.82084142
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.78494271
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.75533537
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.58964104
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.55240096
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48141338
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46103953
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.43708547
21XRN2_22483619_ChIP-Seq_HELA_Human2.41318532
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.36992727
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32522243
24* ELK3_25401928_ChIP-Seq_HUVEC_Human2.30940720
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26467647
26AR_21909140_ChIP-Seq_LNCAP_Human2.26276363
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.19046310
28HIF1A_21447827_ChIP-Seq_MCF-7_Human2.16072933
29NANOG_18555785_ChIP-Seq_MESCs_Mouse2.15061960
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.13674137
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10637616
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06029877
33TRIM28_21343339_ChIP-Seq_HEK293_Human2.03483350
34SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.00531584
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95066595
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94327656
37ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.93059130
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91672596
39VDR_23849224_ChIP-Seq_CD4+_Human1.88975145
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.87827394
41* ATF3_27146783_Chip-Seq_COLON_Human1.86853088
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.86059440
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.83828203
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83541562
45* RACK7_27058665_Chip-Seq_MCF-7_Human1.83049240
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81409505
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80947835
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.75927328
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.75927328
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.75927328
51DCP1A_22483619_ChIP-Seq_HELA_Human1.74764053
52TTF2_22483619_ChIP-Seq_HELA_Human1.74335875
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.72792011
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.72740139
55TCF3_18692474_ChIP-Seq_MEFs_Mouse1.72436612
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.70046121
57GABP_19822575_ChIP-Seq_HepG2_Human1.67626755
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66851030
59HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.63753839
60* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63701240
61FOXP3_21729870_ChIP-Seq_TREG_Human1.63512411
62LXR_22292898_ChIP-Seq_THP-1_Human1.63181261
63RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.59357030
64TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57920877
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57568459
66* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.54880988
67* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.54880988
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.54274714
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52740261
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48765083
71NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.47746358
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.47635398
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46651951
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.45288837
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44909972
76* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44832122
77VDR_21846776_ChIP-Seq_THP-1_Human1.44393932
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.43781833
79CLOCK_20551151_ChIP-Seq_293T_Human1.43653513
80UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.42936739
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42705676
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41499051
83SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41001137
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40533231
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40027589
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39725257
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.39512577
88ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.35762149
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.35342594
90MYC_22102868_ChIP-Seq_BL_Human1.35214725
91* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34569424
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33413973
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32388818
94* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32248360
95ELK1_19687146_ChIP-ChIP_HELA_Human1.30905742
96TCF3_18692474_ChIP-Seq_MESCs_Mouse1.30418693
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29899593
98RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29813959
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28915886
100* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.28848114
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26846063
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25333466
103OCT4_18692474_ChIP-Seq_MEFs_Mouse1.23597111
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23501161
105KDM5A_27292631_Chip-Seq_BREAST_Human1.23255387
106TP53_22127205_ChIP-Seq_IMR90_Human1.20845685
107ESR2_21235772_ChIP-Seq_MCF-7_Human1.19354537
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18154285
109FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18058787
110* UBF1/2_26484160_Chip-Seq_HMECs_Human1.17269633
111* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17032126
112* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16750474
113NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.15707861
114ELK1_22589737_ChIP-Seq_MCF10A_Human1.14837430
115JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13570637
116THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13160888
117ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13048935
118P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12890078
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12175980
120CIITA_25753668_ChIP-Seq_RAJI_Human1.11825506
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11506668
122DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10373265
123SRF_21415370_ChIP-Seq_HL-1_Mouse1.08680714
124CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08496084
125CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08350158
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07705553
127SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07278531
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06807302
129NANOG_18692474_ChIP-Seq_MEFs_Mouse1.05884184
130HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05691834
131ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05640593
132SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.04706991
133TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04138485
134RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03305914
135* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.01452611
136CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01395724
137SALL1_21062744_ChIP-ChIP_HESCs_Human1.01348954
138NANOG_21062744_ChIP-ChIP_HESCs_Human1.00649378
139PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00524938
140P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99635961
141FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98127656
142JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97183021
143KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97109612
144SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96913157
145* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95779100
146MYC_18940864_ChIP-ChIP_HL60_Human0.95305551
147POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.95025415
148SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94762595
149TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.94545967
150SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94009047
151SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93893404
152P68_20966046_ChIP-Seq_HELA_Human0.93470066
153SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93147213
154TFEB_21752829_ChIP-Seq_HELA_Human0.92841620
155ESR1_21235772_ChIP-Seq_MCF-7_Human0.92728276
156SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91876523
157PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88892935
158CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88070451

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.20339148
2MP0004957_abnormal_blastocyst_morpholog4.50873364
3MP0003111_abnormal_nucleus_morphology3.90729103
4MP0010094_abnormal_chromosome_stability3.86469724
5MP0008438_abnormal_cutaneous_collagen3.74217837
6MP0003077_abnormal_cell_cycle3.72754161
7MP0005257_abnormal_intraocular_pressure3.66549078
8MP0002877_abnormal_melanocyte_morpholog3.55072899
9MP0004272_abnormal_basement_membrane3.16855281
10MP0008057_abnormal_DNA_replication3.07108036
11* MP0003123_paternal_imprinting2.96701836
12MP0003806_abnormal_nucleotide_metabolis2.84794321
13MP0008932_abnormal_embryonic_tissue2.80573209
14MP0001730_embryonic_growth_arrest2.79369592
15MP0008058_abnormal_DNA_repair2.70091317
16MP0003191_abnormal_cellular_cholesterol2.62144687
17MP0003950_abnormal_plasma_membrane2.60155241
18MP0004133_heterotaxia2.57166013
19MP0010234_abnormal_vibrissa_follicle2.55756419
20MP0008007_abnormal_cellular_replicative2.54949887
21MP0003890_abnormal_embryonic-extraembry2.30724058
22MP0001542_abnormal_bone_strength2.30455256
23MP0010030_abnormal_orbit_morphology2.26124307
24MP0005380_embryogenesis_phenotype2.21619619
25MP0001672_abnormal_embryogenesis/_devel2.21619619
26MP0000350_abnormal_cell_proliferation2.20632556
27MP0003718_maternal_effect2.18590589
28MP0002060_abnormal_skin_morphology2.16511249
29MP0010352_gastrointestinal_tract_polyps2.15561135
30MP0001697_abnormal_embryo_size2.15258923
31MP0002653_abnormal_ependyma_morphology2.09263622
32MP0009840_abnormal_foam_cell2.08164790
33MP0003453_abnormal_keratinocyte_physiol2.03450690
34MP0003941_abnormal_skin_development2.03315954
35MP0002084_abnormal_developmental_patter2.01818893
36MP0005058_abnormal_lysosome_morphology2.01541310
37MP0005451_abnormal_body_composition1.99912721
38MP0000858_altered_metastatic_potential1.99685255
39MP0003984_embryonic_growth_retardation1.98766141
40MP0002088_abnormal_embryonic_growth/wei1.94646161
41MP0003119_abnormal_digestive_system1.91436464
42MP0004510_myositis1.91356875
43MP0002085_abnormal_embryonic_tissue1.90496425
44MP0003567_abnormal_fetal_cardiomyocyte1.88732471
45* MP0002086_abnormal_extraembryonic_tissu1.84446024
46MP0005623_abnormal_meninges_morphology1.80362997
47MP0003315_abnormal_perineum_morphology1.79777286
48MP0000751_myopathy1.78518444
49MP0002080_prenatal_lethality1.74360934
50MP0002332_abnormal_exercise_endurance1.71038776
51MP0004264_abnormal_extraembryonic_tissu1.70233112
52* MP0003121_genomic_imprinting1.68924755
53MP0000762_abnormal_tongue_morphology1.66550527
54MP0003279_aneurysm1.64821489
55* MP0004197_abnormal_fetal_growth/weight/1.63525177
56MP0006292_abnormal_olfactory_placode1.57505440
57MP0004858_abnormal_nervous_system1.56433615
58MP0000537_abnormal_urethra_morphology1.56059981
59MP0008877_abnormal_DNA_methylation1.52730762
60MP0005165_increased_susceptibility_to1.50341732
61MP0010368_abnormal_lymphatic_system1.50327350
62MP0001216_abnormal_epidermal_layer1.48654713
63MP0006054_spinal_hemorrhage1.46090857
64MP0009780_abnormal_chondrocyte_physiolo1.45819083
65MP0010307_abnormal_tumor_latency1.45758673
66MP0003091_abnormal_cell_migration1.43991322
67MP0000749_muscle_degeneration1.42339344
68MP0003786_premature_aging1.41480390
69MP0008260_abnormal_autophagy1.40817017
70MP0003186_abnormal_redox_activity1.39128846
71MP0000343_altered_response_to1.37864135
72MP0001853_heart_inflammation1.36000480
73MP0001293_anophthalmia1.32093138
74MP0003937_abnormal_limbs/digits/tail_de1.28212153
75MP0001243_abnormal_dermal_layer1.27284337
76MP0005275_abnormal_skin_tensile1.26689813
77MP0005330_cardiomyopathy1.25476394
78MP0000516_abnormal_urinary_system1.25127163
79MP0005367_renal/urinary_system_phenotyp1.25127163
80MP0002111_abnormal_tail_morphology1.23748346
81MP0000313_abnormal_cell_death1.22893248
82MP0005197_abnormal_uvea_morphology1.19914989
83MP0009053_abnormal_anal_canal1.18430043
84MP0000490_abnormal_crypts_of1.18223403
85MP0010771_integument_phenotype1.18102229
86MP0003075_altered_response_to1.17743048
87MP0003566_abnormal_cell_adhesion1.17302156
88MP0003122_maternal_imprinting1.16557650
89MP0004233_abnormal_muscle_weight1.15927201
90MP0000733_abnormal_muscle_development1.15276569
91MP0005076_abnormal_cell_differentiation1.13948569
92MP0001849_ear_inflammation1.13520109
93MP0000579_abnormal_nail_morphology1.10461779
94MP0005360_urolithiasis1.10079759
95MP0005164_abnormal_response_to1.08587601
96MP0002210_abnormal_sex_determination1.07825955
97MP0005670_abnormal_white_adipose1.02715399
98MP0005508_abnormal_skeleton_morphology1.00810792
99MP0002019_abnormal_tumor_incidence0.99922362
100MP0001145_abnormal_male_reproductive0.99553550
101MP0009672_abnormal_birth_weight0.98962715
102MP0003705_abnormal_hypodermis_morpholog0.98055943
103MP0002160_abnormal_reproductive_system0.97833403
104MP0002234_abnormal_pharynx_morphology0.97083643
105MP0000534_abnormal_ureter_morphology0.95801062
106MP0002396_abnormal_hematopoietic_system0.95565157
107MP0002896_abnormal_bone_mineralization0.95414167
108MP0001958_emphysema0.94608803
109MP0001881_abnormal_mammary_gland0.94280410
110MP0000767_abnormal_smooth_muscle0.93685578
111MP0003283_abnormal_digestive_organ0.92912471
112MP0004185_abnormal_adipocyte_glucose0.91311668
113MP0000003_abnormal_adipose_tissue0.88588147
114MP0003221_abnormal_cardiomyocyte_apopto0.86598800
115MP0002102_abnormal_ear_morphology0.86113359
116MP0000653_abnormal_sex_gland0.86040362
117MP0000627_abnormal_mammary_gland0.84902702
118MP0002249_abnormal_larynx_morphology0.84801418
119MP0005501_abnormal_skin_physiology0.82457873
120MP0005023_abnormal_wound_healing0.81924726
121MP0009697_abnormal_copulation0.81896603
122MP0001915_intracranial_hemorrhage0.81177195
123MP0004947_skin_inflammation0.80093553
124MP0001286_abnormal_eye_development0.79348235
125MP0000759_abnormal_skeletal_muscle0.79201494
126MP0000432_abnormal_head_morphology0.79003783
127MP0002177_abnormal_outer_ear0.78723886
128MP0000467_abnormal_esophagus_morphology0.77701932
129MP0000013_abnormal_adipose_tissue0.76972677
130MP0005390_skeleton_phenotype0.76947129
131MP0003942_abnormal_urinary_system0.76485241
132MP0001929_abnormal_gametogenesis0.76468964
133MP0002925_abnormal_cardiovascular_devel0.76341974
134MP0003448_altered_tumor_morphology0.76308644
135MP0000566_synostosis0.76073296
136MP0002127_abnormal_cardiovascular_syste0.75891515
137MP0003936_abnormal_reproductive_system0.75372654
138MP0000049_abnormal_middle_ear0.74768965
139MP0001299_abnormal_eye_distance/0.73917819
140MP0009931_abnormal_skin_appearance0.73787702
141* MP0005384_cellular_phenotype0.73782924
142MP0000358_abnormal_cell_content/0.73355557
143MP0005266_abnormal_metabolism0.72976580
144MP0000428_abnormal_craniofacial_morphol0.72435876
145MP0002098_abnormal_vibrissa_morphology0.70908562
146MP0005193_abnormal_anterior_eye0.70597242
147MP0009703_decreased_birth_body0.70441755
148MP0003861_abnormal_nervous_system0.70310890
149MP0003935_abnormal_craniofacial_develop0.70045402
150MP0002282_abnormal_trachea_morphology0.68437992
151MP0004808_abnormal_hematopoietic_stem0.66813568
152MP0001340_abnormal_eyelid_morphology0.66739542
153MP0005166_decreased_susceptibility_to0.66565822
154MP0001119_abnormal_female_reproductive0.65690701
155MP0005621_abnormal_cell_physiology0.64936832
156MP0005389_reproductive_system_phenotype0.64913481
157MP0009333_abnormal_splenocyte_physiolog0.64196634
158MP0002932_abnormal_joint_morphology0.63839870
159MP0000477_abnormal_intestine_morphology0.63190949
160MP0000678_abnormal_parathyroid_gland0.63160650
161MP0003938_abnormal_ear_development0.61275206
162MP0000750_abnormal_muscle_regeneration0.59626169
163MP0002796_impaired_skin_barrier0.59609403
164MP0006036_abnormal_mitochondrial_physio0.57634412
165MP0005395_other_phenotype0.56505891
166MP0003755_abnormal_palate_morphology0.55364181
167MP0002092_abnormal_eye_morphology0.55349973
168MP0008770_decreased_survivor_rate0.54380955

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.09613316
2Birth length less than 3rd percentile (HP:0003561)5.47357557
3Breast hypoplasia (HP:0003187)5.05584010
4Carpal bone hypoplasia (HP:0001498)4.70472930
5Reduced subcutaneous adipose tissue (HP:0003758)4.04370067
6Selective tooth agenesis (HP:0001592)3.94378735
7Oral leukoplakia (HP:0002745)3.88816321
8Colon cancer (HP:0003003)3.86628539
9Reticulocytopenia (HP:0001896)3.84262974
10Supernumerary spleens (HP:0009799)3.76282768
11Absent radius (HP:0003974)3.75346509
12Atrophic scars (HP:0001075)3.57578868
13Achilles tendon contracture (HP:0001771)3.55258697
14Aplasia involving forearm bones (HP:0009822)3.51521055
15Absent forearm bone (HP:0003953)3.51521055
16Short nail (HP:0001799)3.49314314
17Stenosis of the external auditory canal (HP:0000402)3.47400524
18Distal lower limb muscle weakness (HP:0009053)3.41270888
19Protrusio acetabuli (HP:0003179)3.37378555
20Vertebral compression fractures (HP:0002953)3.32048221
21Distal lower limb amyotrophy (HP:0008944)3.29317855
22Patellar aplasia (HP:0006443)3.23276379
23Aplasia/hypoplasia of the humerus (HP:0006507)3.22006956
24Abnormality of abdominal situs (HP:0011620)3.20701191
25Abdominal situs inversus (HP:0003363)3.20701191
26Abnormality of the distal phalanges of the toes (HP:0010182)3.20221574
27Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.17440071
28Distal upper limb amyotrophy (HP:0007149)3.17413049
29Upper limb amyotrophy (HP:0009129)3.17413049
30Ependymoma (HP:0002888)3.15555684
31Medulloblastoma (HP:0002885)3.14100042
32Abnormality of cells of the erythroid lineage (HP:0012130)3.12271924
33Abnormality of the Achilles tendon (HP:0005109)3.11116887
34Abnormality of the labia minora (HP:0012880)3.07911148
35Axonal loss (HP:0003447)3.07614557
36Aplasia/Hypoplasia of the patella (HP:0006498)3.06900834
37Increased connective tissue (HP:0009025)2.98704868
38Osteolytic defects of the phalanges of the hand (HP:0009771)2.98156702
39Osteolytic defects of the hand bones (HP:0009699)2.98156702
40Spinal rigidity (HP:0003306)2.96097336
41Fragile skin (HP:0001030)2.90696318
42Rough bone trabeculation (HP:0100670)2.90102513
43Cerebral hypomyelination (HP:0006808)2.88456044
44Generalized amyotrophy (HP:0003700)2.86185621
45Macrocytic anemia (HP:0001972)2.86019034
46Glucose intolerance (HP:0000833)2.84938515
47Aplastic anemia (HP:0001915)2.80005265
4811 pairs of ribs (HP:0000878)2.76879413
49Abnormality of the umbilical cord (HP:0010881)2.75662971
50Elbow flexion contracture (HP:0002987)2.75357701
51Abnormal number of erythroid precursors (HP:0012131)2.73604017
52Entropion (HP:0000621)2.70679538
53Short humerus (HP:0005792)2.70226640
54Absent thumb (HP:0009777)2.67429610
55Natal tooth (HP:0000695)2.63087872
56Degeneration of anterior horn cells (HP:0002398)2.62591991
57Abnormality of the anterior horn cell (HP:0006802)2.62591991
58Horseshoe kidney (HP:0000085)2.60231884
59Missing ribs (HP:0000921)2.59074739
60Abnormal number of incisors (HP:0011064)2.58793556
61Upper limb muscle weakness (HP:0003484)2.58007371
62Meckel diverticulum (HP:0002245)2.57832123
63Hand muscle atrophy (HP:0009130)2.57729076
64Ankle contracture (HP:0006466)2.55864001
65Testicular atrophy (HP:0000029)2.54692347
66Follicular hyperkeratosis (HP:0007502)2.47457124
67Mildly elevated creatine phosphokinase (HP:0008180)2.47375499
68Abnormalities of placenta or umbilical cord (HP:0001194)2.42126623
69Impulsivity (HP:0100710)2.41460780
70Deviation of the thumb (HP:0009603)2.41106748
71Fused cervical vertebrae (HP:0002949)2.39163484
72Nail dystrophy (HP:0008404)2.38603238
73Breast aplasia (HP:0100783)2.38497805
74Chromsome breakage (HP:0040012)2.38376636
75Premature ovarian failure (HP:0008209)2.37833838
76Trismus (HP:0000211)2.37390521
77Abnormality of the ileum (HP:0001549)2.37102566
78Agnosia (HP:0010524)2.36486602
79Asplenia (HP:0001746)2.33200457
80Difficulty climbing stairs (HP:0003551)2.31974352
81Alopecia of scalp (HP:0002293)2.31945644
82Chromosomal breakage induced by crosslinking agents (HP:0003221)2.29527063
83Rhabdomyosarcoma (HP:0002859)2.27780293
84Abnormality of liposaccharide metabolism (HP:0010968)2.26677907
85Abnormality of glycosphingolipid metabolism (HP:0004343)2.26677907
86Abnormality of glycolipid metabolism (HP:0010969)2.26677907
87Neoplasm of the pancreas (HP:0002894)2.26525541
88Proximal placement of thumb (HP:0009623)2.26330194
89Abnormal lung lobation (HP:0002101)2.25820077
90Shawl scrotum (HP:0000049)2.25357447
91Onycholysis (HP:0001806)2.24480821
92Short clavicles (HP:0000894)2.24428280
93Aplasia/Hypoplasia of the breasts (HP:0010311)2.22902451
94Rectovaginal fistula (HP:0000143)2.19537484
95Rectal fistula (HP:0100590)2.19537484
96Multiple enchondromatosis (HP:0005701)2.18974241
97Aplasia/Hypoplasia involving the musculature (HP:0001460)2.17636971
98Pallor (HP:0000980)2.17021746
99Vascular calcification (HP:0004934)2.15909828
100Acanthosis nigricans (HP:0000956)2.15545912
101Cardiovascular calcification (HP:0011915)2.15229988
102Abnormal trabecular bone morphology (HP:0100671)2.15106365
103Atresia of the external auditory canal (HP:0000413)2.14171738
104Anal stenosis (HP:0002025)2.13643380
105Ulnar bowing (HP:0003031)2.12183504
106Aplasia/Hypoplasia of the spleen (HP:0010451)2.11995862
107Hyperacusis (HP:0010780)2.11906593
108Wormian bones (HP:0002645)2.10037410
109Abnormality of pyrimidine metabolism (HP:0004353)2.09976566
110Microretrognathia (HP:0000308)2.09801902
111Lower limb amyotrophy (HP:0007210)2.09170828
112Abnormality of the preputium (HP:0100587)2.08300864
113Broad face (HP:0000283)2.07864753
114Irregular epiphyses (HP:0010582)2.07388429
115Tracheoesophageal fistula (HP:0002575)2.07164331
116Premature graying of hair (HP:0002216)2.06551932
117Microglossia (HP:0000171)2.05545861
118Aplasia/Hypoplasia of the clavicles (HP:0006710)2.04854019
119Preauricular skin tag (HP:0000384)2.04138017
120Neoplasm of the oral cavity (HP:0100649)2.04117003
121Blue sclerae (HP:0000592)2.03862361
122Abnormality of dentin (HP:0010299)2.03222097
123Fragile nails (HP:0001808)2.02441521
124Prolonged neonatal jaundice (HP:0006579)2.02052608
125Amniotic constriction ring (HP:0009775)2.01896987
126Abnormality of placental membranes (HP:0011409)2.01896987
127Ectopic kidney (HP:0000086)2.01154988
128Triphalangeal thumb (HP:0001199)1.99823572
129Hypoplasia of the radius (HP:0002984)1.99505600
130Hypokinesia (HP:0002375)1.99442481
131Glossoptosis (HP:0000162)1.98415891
132Hydroureter (HP:0000072)1.98289396
133Esophageal atresia (HP:0002032)1.97782463
134Adrenal hypoplasia (HP:0000835)1.97461520
135J-shaped sella turcica (HP:0002680)1.97024787
136Megaloblastic anemia (HP:0001889)1.96889055
137Abnormality of glycolysis (HP:0004366)1.96543611
138Abnormal umbilical cord blood vessels (HP:0011403)1.96365984
139Single umbilical artery (HP:0001195)1.96365984
140Abnormality of the fetal cardiovascular system (HP:0010948)1.96365984
141Abnormality of chromosome stability (HP:0003220)1.95236003
142Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.95162129
143Decreased activity of mitochondrial respiratory chain (HP:0008972)1.95162129
144Amyloidosis (HP:0011034)1.94828099
145Bladder diverticulum (HP:0000015)1.94480965
146High anterior hairline (HP:0009890)1.94390641
147Aplasia/Hypoplasia of the sternum (HP:0006714)1.93944375
148Insulin resistance (HP:0000855)1.93808476
149Cleft eyelid (HP:0000625)1.93143057
150Long palpebral fissure (HP:0000637)1.92887860
151Nuclear cataract (HP:0100018)1.92843307
152Abnormal gallbladder physiology (HP:0012438)1.92304439
153Cholecystitis (HP:0001082)1.92304439
154Vaginal fistula (HP:0004320)1.91961563
155Cervical subluxation (HP:0003308)1.91803020
156Insomnia (HP:0100785)1.91031222
157Short 1st metacarpal (HP:0010034)1.90261467
158Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.90261467
159Myelodysplasia (HP:0002863)1.90222504
160Short thumb (HP:0009778)1.90206838
161Down-sloping shoulders (HP:0200021)1.89234748
162Myocardial infarction (HP:0001658)1.89124161
163Sparse eyelashes (HP:0000653)1.88223377
164CNS hypomyelination (HP:0003429)1.88169826
165Intestinal atresia (HP:0011100)1.88053031
166Type I transferrin isoform profile (HP:0003642)1.87208120
167Cellular immunodeficiency (HP:0005374)1.86977278
168Amaurosis fugax (HP:0100576)1.85950260
169Duplicated collecting system (HP:0000081)1.85775615
170Increased serum pyruvate (HP:0003542)1.85684014
171Hyperparathyroidism (HP:0000843)1.85118873
172Metaphyseal cupping (HP:0003021)1.85060856
173Congenital ichthyosiform erythroderma (HP:0007431)1.84532673
174Milia (HP:0001056)1.83476694
175Multiple lipomas (HP:0001012)1.83104763
176Skin tags (HP:0010609)1.82543689
177Joint stiffness (HP:0001387)1.82392807
178Intestinal fistula (HP:0100819)1.81387618
179Secondary amenorrhea (HP:0000869)1.80918216
180Aplasia/Hypoplasia of the uvula (HP:0010293)1.80815433
181Abnormal mitochondria in muscle tissue (HP:0008316)1.78711225
182Rib fusion (HP:0000902)1.78302598
183Small intestinal stenosis (HP:0012848)1.78186503
184Duodenal stenosis (HP:0100867)1.78186503
185Progressive muscle weakness (HP:0003323)1.77157910
186Aortic dissection (HP:0002647)1.74027593
187Advanced eruption of teeth (HP:0006288)1.73341292
188Limb-girdle muscle atrophy (HP:0003797)1.70159314
189Mitral regurgitation (HP:0001653)1.67989416
190Thick nail (HP:0001805)1.67850580
191Hypertensive crisis (HP:0100735)1.66973291
192Abnormal delivery (HP:0001787)1.66275741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.87655713
2MST1R4.24805774
3WEE14.19437822
4PLK43.92987551
5CDC73.82035414
6IRAK33.59341911
7EIF2AK13.04249615
8NEK12.81608361
9SRPK12.75722928
10RPS6KB22.74029039
11VRK22.56758218
12LMTK22.50111919
13ARAF2.49962816
14PIM22.46882442
15TTK2.42923216
16NEK22.37253460
17EPHA22.21856049
18SIK12.18397456
19ACVR1B2.13966743
20TSSK62.09065922
21CDK121.92808265
22NME21.90093229
23CDK71.89979281
24PLK11.86851047
25ERN11.85696538
26TAOK21.83505155
27VRK11.78591812
28LATS21.76327368
29MAP3K81.75489258
30PTK21.74796685
31TGFBR11.64596161
32STK161.59577114
33PLK31.56921556
34EPHB21.52242519
35TESK21.51906135
36BRSK21.50520183
37STK101.48793437
38MOS1.47599756
39MKNK11.47259299
40AURKB1.43163644
41EIF2AK31.42601605
42TRIB31.40484105
43PAK41.35680129
44MYLK1.35185190
45PASK1.34346095
46SCYL21.33473155
47STK38L1.33031149
48ATR1.32340146
49AURKA1.31947019
50CHEK21.24777786
51SMG11.20831325
52PNCK1.20290108
53DYRK31.17316372
54CHEK11.17265781
55MAP3K121.16659545
56ILK1.14630155
57ICK1.14556738
58AKT31.13781225
59MAPKAPK31.12373122
60MKNK21.12248123
61CDK41.11261580
62EEF2K1.10204952
63ALK1.06518030
64TLK11.03854338
65RPS6KA41.03444853
66TTN0.98428929
67BCKDK0.95157415
68BRAF0.92339434
69BRD40.92263151
70MST40.91632027
71KDR0.90151500
72RIPK10.88692545
73PRPF4B0.88247691
74LRRK20.85668403
75CDK20.83849387
76PRKCI0.83174224
77BMX0.82559163
78ATM0.80465072
79LATS10.77303694
80FLT30.77084194
81DAPK10.76084227
82TGFBR20.75260379
83PDGFRA0.74787271
84BRSK10.74748068
85CSNK2A20.72470813
86STK40.67091251
87MAP3K110.66569582
88TAOK10.66084489
89PAK10.65461570
90PRKG20.64723446
91NME10.64077266
92GRK70.62028598
93DYRK20.61026886
94EPHB10.60995284
95AKT20.60545635
96ZAK0.59365647
97CSNK2A10.58375219
98PBK0.57807319
99TBK10.57454824
100PTK60.56950112
101PIM10.56906063
102DAPK30.56852984
103CDK10.55494845
104MAP3K100.55474095
105CSNK1E0.55408490
106MELK0.55265826
107PKN20.55104539
108MTOR0.54560781
109MAP2K20.53657667
110SIK30.53350625
111MET0.53346460
112NTRK10.52968680
113CDK80.52242337
114PRKD20.51705276
115PHKG20.49879896
116PHKG10.49879896
117CAMK2G0.48413239
118TESK10.44946387
119PDK20.41183886
120STK30.41163305
121EIF2AK20.39825360
122MAP2K30.39076197
123CDK60.38254147
124PINK10.37999036
125DMPK0.37569158
126RPS6KA50.37065099
127DDR20.36876724
128PTK2B0.36777322
129ABL20.36698150
130MAPKAPK20.36487986
131ROCK20.32450993
132IRAK20.31893312
133MAP3K30.31810267
134CDK140.30755475
135CDK11A0.30015644
136CDK180.29507358
137CDK150.29193257
138GRK50.28786095
139CDK90.28617633
140KSR20.28275033
141ERBB40.28234332
142PRKDC0.28053175
143GSK3A0.27557867
144LIMK10.27458459
145STK380.26302497
146CSNK1G30.26204088
147CSNK1A1L0.25727212
148FGFR10.25094073
149MAP3K90.22852091
150ROCK10.22434609
151CSNK1D0.21642603
152MAPK140.20904736
153RAF10.20626696
154PDK30.19979374
155PDK40.19979374
156CDK190.19620151
157PAK20.18044856

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.77470387
2Mismatch repair_Homo sapiens_hsa034304.20102401
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.13515122
4RNA polymerase_Homo sapiens_hsa030203.99278341
5Ribosome_Homo sapiens_hsa030103.69895637
6Spliceosome_Homo sapiens_hsa030403.50257405
7RNA transport_Homo sapiens_hsa030133.40677999
8One carbon pool by folate_Homo sapiens_hsa006703.08945684
9Proteasome_Homo sapiens_hsa030502.99257187
10Nucleotide excision repair_Homo sapiens_hsa034202.84816899
11Pyrimidine metabolism_Homo sapiens_hsa002402.75228743
12Homologous recombination_Homo sapiens_hsa034402.65866727
13Cell cycle_Homo sapiens_hsa041102.60271193
14Base excision repair_Homo sapiens_hsa034102.59846706
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.53729411
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.09277220
17RNA degradation_Homo sapiens_hsa030182.02449938
18Vibrio cholerae infection_Homo sapiens_hsa051101.89258782
19Basal transcription factors_Homo sapiens_hsa030221.86716771
20Fanconi anemia pathway_Homo sapiens_hsa034601.73165857
21N-Glycan biosynthesis_Homo sapiens_hsa005101.66670407
22Sulfur metabolism_Homo sapiens_hsa009201.65833795
23mRNA surveillance pathway_Homo sapiens_hsa030151.61660518
24Other glycan degradation_Homo sapiens_hsa005111.50679313
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.48373610
26p53 signaling pathway_Homo sapiens_hsa041151.48292483
27Folate biosynthesis_Homo sapiens_hsa007901.44694003
28Non-homologous end-joining_Homo sapiens_hsa034501.44247398
29Purine metabolism_Homo sapiens_hsa002301.43036983
30Alzheimers disease_Homo sapiens_hsa050101.36301606
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.33318811
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33230137
33Biosynthesis of amino acids_Homo sapiens_hsa012301.23764942
34Salmonella infection_Homo sapiens_hsa051321.23509571
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.22786038
36Fatty acid elongation_Homo sapiens_hsa000621.18165297
37Focal adhesion_Homo sapiens_hsa045101.14300412
38ECM-receptor interaction_Homo sapiens_hsa045121.12622971
39Lysosome_Homo sapiens_hsa041421.11138860
40Proteoglycans in cancer_Homo sapiens_hsa052051.05956811
41Epstein-Barr virus infection_Homo sapiens_hsa051691.04933284
42Systemic lupus erythematosus_Homo sapiens_hsa053221.04873475
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03696062
44Selenocompound metabolism_Homo sapiens_hsa004501.00992540
45Oocyte meiosis_Homo sapiens_hsa041141.00715756
46Thyroid cancer_Homo sapiens_hsa052160.92153369
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91572338
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.89910380
49Prion diseases_Homo sapiens_hsa050200.89627395
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86805403
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86410598
52Hippo signaling pathway_Homo sapiens_hsa043900.86226050
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84965704
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83626838
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83561551
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81774175
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81000779
58Endocytosis_Homo sapiens_hsa041440.79559803
59Basal cell carcinoma_Homo sapiens_hsa052170.79444998
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78700979
61TGF-beta signaling pathway_Homo sapiens_hsa043500.75549508
62Chronic myeloid leukemia_Homo sapiens_hsa052200.75202330
63Glutathione metabolism_Homo sapiens_hsa004800.75183728
64Viral carcinogenesis_Homo sapiens_hsa052030.72507608
65Pentose phosphate pathway_Homo sapiens_hsa000300.71929972
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70132547
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69656618
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68747602
69Carbon metabolism_Homo sapiens_hsa012000.67107716
70TNF signaling pathway_Homo sapiens_hsa046680.64014932
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62263126
72Huntingtons disease_Homo sapiens_hsa050160.60670390
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60098486
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59670135
75Amoebiasis_Homo sapiens_hsa051460.59377198
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58963676
77HTLV-I infection_Homo sapiens_hsa051660.57173900
78Pancreatic cancer_Homo sapiens_hsa052120.56984880
79MicroRNAs in cancer_Homo sapiens_hsa052060.55988023
80Vitamin B6 metabolism_Homo sapiens_hsa007500.55884775
81Sulfur relay system_Homo sapiens_hsa041220.53311579
82Herpes simplex infection_Homo sapiens_hsa051680.52452218
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50124745
84Sphingolipid metabolism_Homo sapiens_hsa006000.49487560
85Antigen processing and presentation_Homo sapiens_hsa046120.49115643
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45063344
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44559175
88Hedgehog signaling pathway_Homo sapiens_hsa043400.41323600
89Arginine and proline metabolism_Homo sapiens_hsa003300.40093954
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.39320765
91Hepatitis C_Homo sapiens_hsa051600.38855300
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37681752
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37419179
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.36870689
95Bladder cancer_Homo sapiens_hsa052190.36759770
96Tight junction_Homo sapiens_hsa045300.36446743
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36365361
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35882106
99Vitamin digestion and absorption_Homo sapiens_hsa049770.35740475
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35382724
101Fructose and mannose metabolism_Homo sapiens_hsa000510.35132080
102Adherens junction_Homo sapiens_hsa045200.34023542
103Fat digestion and absorption_Homo sapiens_hsa049750.33303237
104Dilated cardiomyopathy_Homo sapiens_hsa054140.32787268
105Linoleic acid metabolism_Homo sapiens_hsa005910.32309266
106Small cell lung cancer_Homo sapiens_hsa052220.32221699
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31934987
108Steroid biosynthesis_Homo sapiens_hsa001000.31653294
109Parkinsons disease_Homo sapiens_hsa050120.30200378
110Alcoholism_Homo sapiens_hsa050340.30065722
111Metabolic pathways_Homo sapiens_hsa011000.29708328
112Galactose metabolism_Homo sapiens_hsa000520.29318981
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28620690
114HIF-1 signaling pathway_Homo sapiens_hsa040660.27315241
115Notch signaling pathway_Homo sapiens_hsa043300.26805818
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24889348
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24853151
118Pathways in cancer_Homo sapiens_hsa052000.24852214
119Protein export_Homo sapiens_hsa030600.24271899
120Colorectal cancer_Homo sapiens_hsa052100.22440688
121Phenylalanine metabolism_Homo sapiens_hsa003600.21891500
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19835066
123Pyruvate metabolism_Homo sapiens_hsa006200.19454361
124Wnt signaling pathway_Homo sapiens_hsa043100.18869026
125Arachidonic acid metabolism_Homo sapiens_hsa005900.18651498
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.17709364
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15505280
128Melanoma_Homo sapiens_hsa052180.13398699
129Apoptosis_Homo sapiens_hsa042100.12426652
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.09624299
131Legionellosis_Homo sapiens_hsa051340.09095371
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.06850731
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.05546222
134Oxidative phosphorylation_Homo sapiens_hsa001900.04021750
135Shigellosis_Homo sapiens_hsa051310.03992611
136Lysine degradation_Homo sapiens_hsa003100.03554229
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.02498830
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.02039814

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